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Network neighborhood for query Sequence : PTTG1_MOUSE

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PTTG1_MOUSE
SwissProt Accessions	Q9CQJ7, O88887, Q9Z2E6	Gene names	Pttg1, Pttg
Domain Architecture
Description	Securin (Pituitary tumor-transforming protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PTTG1_MOUSE
θ value	2.29227e-112 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	15	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	Q9CQJ7, O88887, Q9Z2E6	Gene names	Pttg1, Pttg
Domain Architecture
Description	Securin (Pituitary tumor-transforming protein 1).

PTTG1_HUMAN
θ value	9.0981e-77 (rank : 2)	NC score	0.979175 (rank : 2)
Query Neighborhood Hits	15	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	O95997	Gene names	PTTG1, EAP1, PTTG, TUTR1
Domain Architecture
Description	Securin (Pituitary tumor-transforming protein 1) (Tumor-transforming protein 1) (Esp1-associated protein) (hPTTG).

4F2_MOUSE
θ value	0.365318 (rank : 3)	NC score	0.086147 (rank : 3)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	P10852, Q54AH5	Gene names	Slc3a2, Mdu1
Domain Architecture
Description	4F2 cell-surface antigen heavy chain (4F2hc).

FRAP_MOUSE
θ value	0.813845 (rank : 4)	NC score	0.056941 (rank : 5)
Query Neighborhood Hits	15	Target Neighborhood Hits	77	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

MLL2_HUMAN
θ value	1.38821 (rank : 5)	NC score	0.022143 (rank : 8)
Query Neighborhood Hits	15	Target Neighborhood Hits	1788	Shared Neighborhood Hits	5
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

FRAP_HUMAN
θ value	1.81305 (rank : 6)	NC score	0.054229 (rank : 6)
Query Neighborhood Hits	15	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

WNK2_HUMAN
θ value	1.81305 (rank : 7)	NC score	0.008544 (rank : 14)
Query Neighborhood Hits	15	Target Neighborhood Hits	1407	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

CQ028_MOUSE
θ value	3.0926 (rank : 8)	NC score	0.034446 (rank : 7)
Query Neighborhood Hits	15	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R1F6, Q8C8V6	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C17orf28 homolog.

KAISO_HUMAN
θ value	4.03905 (rank : 9)	NC score	0.006786 (rank : 15)
Query Neighborhood Hits	15	Target Neighborhood Hits	840	Shared Neighborhood Hits	3
SwissProt Accessions	Q86T24, O00319, Q7Z361, Q8IVP6, Q8N3P0	Gene names	ZBTB33, KAISO, ZNF348
Domain Architecture	No domain graphic available
Description	Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33).

4F2_HUMAN
θ value	5.27518 (rank : 10)	NC score	0.065659 (rank : 4)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	P08195, Q13543	Gene names	SLC3A2, MDU1
Domain Architecture
Description	4F2 cell-surface antigen heavy chain (4F2hc) (Lymphocyte activation antigen 4F2 large subunit) (4F2 heavy chain antigen) (CD98 antigen).

RUSC2_HUMAN
θ value	6.88961 (rank : 11)	NC score	0.019223 (rank : 9)
Query Neighborhood Hits	15	Target Neighborhood Hits	205	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

TP53B_MOUSE
θ value	6.88961 (rank : 12)	NC score	0.019050 (rank : 11)
Query Neighborhood Hits	15	Target Neighborhood Hits	644	Shared Neighborhood Hits	5
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

COG2_HUMAN
θ value	8.99809 (rank : 13)	NC score	0.019166 (rank : 10)
Query Neighborhood Hits	15	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q14746	Gene names	COG2, LDLC
Domain Architecture
Description	Conserved oligomeric Golgi complex component 2 (Low density lipoprotein receptor defect C-complementing protein).

JPH1_MOUSE
θ value	8.99809 (rank : 14)	NC score	0.010724 (rank : 12)
Query Neighborhood Hits	15	Target Neighborhood Hits	120	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

ZYX_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.009311 (rank : 13)
Query Neighborhood Hits	15	Target Neighborhood Hits	387	Shared Neighborhood Hits	5
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

Hits sorted by NC score

PTTG1_MOUSE
NC score	0.999962 (rank : 1)	θ value	2.29227e-112 (rank : 1)
Query Neighborhood Hits	15	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	Q9CQJ7, O88887, Q9Z2E6	Gene names	Pttg1, Pttg
Domain Architecture
Description	Securin (Pituitary tumor-transforming protein 1).

PTTG1_HUMAN
NC score	0.979175 (rank : 2)	θ value	9.0981e-77 (rank : 2)
Query Neighborhood Hits	15	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	O95997	Gene names	PTTG1, EAP1, PTTG, TUTR1
Domain Architecture
Description	Securin (Pituitary tumor-transforming protein 1) (Tumor-transforming protein 1) (Esp1-associated protein) (hPTTG).

4F2_MOUSE
NC score	0.086147 (rank : 3)	θ value	0.365318 (rank : 3)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	P10852, Q54AH5	Gene names	Slc3a2, Mdu1
Domain Architecture
Description	4F2 cell-surface antigen heavy chain (4F2hc).

4F2_HUMAN
NC score	0.065659 (rank : 4)	θ value	5.27518 (rank : 10)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	P08195, Q13543	Gene names	SLC3A2, MDU1
Domain Architecture
Description	4F2 cell-surface antigen heavy chain (4F2hc) (Lymphocyte activation antigen 4F2 large subunit) (4F2 heavy chain antigen) (CD98 antigen).

FRAP_MOUSE
NC score	0.056941 (rank : 5)	θ value	0.813845 (rank : 4)
Query Neighborhood Hits	15	Target Neighborhood Hits	77	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
NC score	0.054229 (rank : 6)	θ value	1.81305 (rank : 6)
Query Neighborhood Hits	15	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

CQ028_MOUSE
NC score	0.034446 (rank : 7)	θ value	3.0926 (rank : 8)
Query Neighborhood Hits	15	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R1F6, Q8C8V6	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C17orf28 homolog.

MLL2_HUMAN
NC score	0.022143 (rank : 8)	θ value	1.38821 (rank : 5)
Query Neighborhood Hits	15	Target Neighborhood Hits	1788	Shared Neighborhood Hits	5
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

RUSC2_HUMAN
NC score	0.019223 (rank : 9)	θ value	6.88961 (rank : 11)
Query Neighborhood Hits	15	Target Neighborhood Hits	205	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

COG2_HUMAN
NC score	0.019166 (rank : 10)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	15	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q14746	Gene names	COG2, LDLC
Domain Architecture
Description	Conserved oligomeric Golgi complex component 2 (Low density lipoprotein receptor defect C-complementing protein).

TP53B_MOUSE
NC score	0.019050 (rank : 11)	θ value	6.88961 (rank : 12)
Query Neighborhood Hits	15	Target Neighborhood Hits	644	Shared Neighborhood Hits	5
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

JPH1_MOUSE
NC score	0.010724 (rank : 12)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	15	Target Neighborhood Hits	120	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

ZYX_HUMAN
NC score	0.009311 (rank : 13)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	15	Target Neighborhood Hits	387	Shared Neighborhood Hits	5
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

WNK2_HUMAN
NC score	0.008544 (rank : 14)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	15	Target Neighborhood Hits	1407	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

KAISO_HUMAN
NC score	0.006786 (rank : 15)	θ value	4.03905 (rank : 9)
Query Neighborhood Hits	15	Target Neighborhood Hits	840	Shared Neighborhood Hits	3
SwissProt Accessions	Q86T24, O00319, Q7Z361, Q8IVP6, Q8N3P0	Gene names	ZBTB33, KAISO, ZNF348
Domain Architecture	No domain graphic available
Description	Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33).