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Network neighborhood for query Sequence : TKT_MOUSE

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TKT_MOUSE
SwissProt Accessions	P40142	Gene names	Tkt
Domain Architecture
Description	Transketolase (EC 2.2.1.1) (TK) (P68).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TKT2_HUMAN
θ value	0 (rank : 1)	NC score	0.984037 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	P51854	Gene names	TKTL1, TKR, TKT2
Domain Architecture
Description	Transketolase-like 1 (EC 2.2.1.1) (Transketolase 2) (TK 2) (Transketolase-related protein).

TKT_HUMAN
θ value	0 (rank : 2)	NC score	0.999548 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	P29401, Q8TBA3, Q96HH3	Gene names	TKT
Domain Architecture
Description	Transketolase (EC 2.2.1.1) (TK).

TKT_MOUSE
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P40142	Gene names	Tkt
Domain Architecture
Description	Transketolase (EC 2.2.1.1) (TK) (P68).

ODPB_HUMAN
θ value	6.43352e-06 (rank : 4)	NC score	0.320900 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	5
SwissProt Accessions	P11177, Q6FH45, Q9BQ27, Q9UFK3	Gene names	PDHB, PHE1B
Domain Architecture
Description	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor (EC 1.2.4.1) (PDHE1-B).

ODPB_MOUSE
θ value	3.19293e-05 (rank : 5)	NC score	0.313736 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	7	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D051	Gene names	Pdhb
Domain Architecture
Description	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor (EC 1.2.4.1) (PDHE1-B).

ODBA_MOUSE
θ value	0.0563607 (rank : 6)	NC score	0.133328 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	P50136	Gene names	Bckdha
Domain Architecture
Description	2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDH E1-alpha).

ODBA_HUMAN
θ value	0.0961366 (rank : 7)	NC score	0.129623 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	P12694, Q16034, Q16472	Gene names	BCKDHA
Domain Architecture
Description	2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDH E1-alpha) (BCKDE1A).

ODPA_HUMAN
θ value	0.47712 (rank : 8)	NC score	0.095809 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	P08559, Q9NP12, Q9UBJ8, Q9UBU0, Q9UNG4, Q9UNG5	Gene names	PDHA1, PHE1A
Domain Architecture
Description	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type I).

ODPA_MOUSE
θ value	0.47712 (rank : 9)	NC score	0.096065 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	P35486	Gene names	Pdha1, Pdha-1
Domain Architecture
Description	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type I).

RAE2_HUMAN
θ value	2.36792 (rank : 10)	NC score	0.018355 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	P26374, Q9H1Y4	Gene names	CHML, REP2
Domain Architecture
Description	Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein).

ODPAT_HUMAN
θ value	3.0926 (rank : 11)	NC score	0.079928 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	P29803	Gene names	PDHA2
Domain Architecture
Description	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type II).

CDK9_HUMAN
θ value	6.88961 (rank : 12)	NC score	0.000464 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	822	Shared Neighborhood Hits	2
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

IFRD1_MOUSE
θ value	6.88961 (rank : 13)	NC score	0.014292 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	P19182, P21835, P70228	Gene names	Ifrd1, Tis7
Domain Architecture
Description	Interferon-related developmental regulator 1 (Nerve growth factor- inducible protein PC4) (TPA-induced sequence 7) (TIS7 protein).

ODPAT_MOUSE
θ value	6.88961 (rank : 14)	NC score	0.074705 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	P35487	Gene names	Pdha2, Pdha-2, Pdhal
Domain Architecture
Description	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type II).

FRAP_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.007872 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

MYH10_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.004713 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	1620	Shared Neighborhood Hits	5
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.004731 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	1612	Shared Neighborhood Hits	5
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH9_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.004201 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	1829	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

ODBB_HUMAN
θ value	θ > 10 (rank : 19)	NC score	0.115443 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P21953	Gene names	BCKDHB
Domain Architecture
Description	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDH E1-beta).

Hits sorted by NC score

TKT_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P40142	Gene names	Tkt
Domain Architecture
Description	Transketolase (EC 2.2.1.1) (TK) (P68).

TKT_HUMAN
NC score	0.999548 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	P29401, Q8TBA3, Q96HH3	Gene names	TKT
Domain Architecture
Description	Transketolase (EC 2.2.1.1) (TK).

TKT2_HUMAN
NC score	0.984037 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	P51854	Gene names	TKTL1, TKR, TKT2
Domain Architecture
Description	Transketolase-like 1 (EC 2.2.1.1) (Transketolase 2) (TK 2) (Transketolase-related protein).

ODPB_HUMAN
NC score	0.320900 (rank : 4)	θ value	6.43352e-06 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	5
SwissProt Accessions	P11177, Q6FH45, Q9BQ27, Q9UFK3	Gene names	PDHB, PHE1B
Domain Architecture
Description	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor (EC 1.2.4.1) (PDHE1-B).

ODPB_MOUSE
NC score	0.313736 (rank : 5)	θ value	3.19293e-05 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	7	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D051	Gene names	Pdhb
Domain Architecture
Description	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor (EC 1.2.4.1) (PDHE1-B).

ODBA_MOUSE
NC score	0.133328 (rank : 6)	θ value	0.0563607 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	P50136	Gene names	Bckdha
Domain Architecture
Description	2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDH E1-alpha).

ODBA_HUMAN
NC score	0.129623 (rank : 7)	θ value	0.0961366 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	P12694, Q16034, Q16472	Gene names	BCKDHA
Domain Architecture
Description	2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDH E1-alpha) (BCKDE1A).

ODBB_HUMAN
NC score	0.115443 (rank : 8)	θ value	θ > 10 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P21953	Gene names	BCKDHB
Domain Architecture
Description	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDH E1-beta).

ODPA_MOUSE
NC score	0.096065 (rank : 9)	θ value	0.47712 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	P35486	Gene names	Pdha1, Pdha-1
Domain Architecture
Description	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type I).

ODPA_HUMAN
NC score	0.095809 (rank : 10)	θ value	0.47712 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	P08559, Q9NP12, Q9UBJ8, Q9UBU0, Q9UNG4, Q9UNG5	Gene names	PDHA1, PHE1A
Domain Architecture
Description	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type I).

ODPAT_HUMAN
NC score	0.079928 (rank : 11)	θ value	3.0926 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	P29803	Gene names	PDHA2
Domain Architecture
Description	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type II).

ODPAT_MOUSE
NC score	0.074705 (rank : 12)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	P35487	Gene names	Pdha2, Pdha-2, Pdhal
Domain Architecture
Description	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type II).

RAE2_HUMAN
NC score	0.018355 (rank : 13)	θ value	2.36792 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	P26374, Q9H1Y4	Gene names	CHML, REP2
Domain Architecture
Description	Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein).

IFRD1_MOUSE
NC score	0.014292 (rank : 14)	θ value	6.88961 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	P19182, P21835, P70228	Gene names	Ifrd1, Tis7
Domain Architecture
Description	Interferon-related developmental regulator 1 (Nerve growth factor- inducible protein PC4) (TPA-induced sequence 7) (TIS7 protein).

FRAP_HUMAN
NC score	0.007872 (rank : 15)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

MYH10_MOUSE
NC score	0.004731 (rank : 16)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	1612	Shared Neighborhood Hits	5
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_HUMAN
NC score	0.004713 (rank : 17)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	1620	Shared Neighborhood Hits	5
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH9_MOUSE
NC score	0.004201 (rank : 18)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	1829	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

CDK9_HUMAN
NC score	0.000464 (rank : 19)	θ value	6.88961 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	822	Shared Neighborhood Hits	2
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).