Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : TNPO1_HUMAN

For an explanation of this page, click here

TNPO1_HUMAN
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TNPO1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	64	Target Neighborhood Hits	64	Shared Neighborhood Hits	64
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

TNPO1_MOUSE
θ value	0 (rank : 2)	NC score	0.999500 (rank : 2)
Query Neighborhood Hits	64	Target Neighborhood Hits	63	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

TNPO2_HUMAN
θ value	0 (rank : 3)	NC score	0.993483 (rank : 4)
Query Neighborhood Hits	64	Target Neighborhood Hits	47	Shared Neighborhood Hits	42
SwissProt Accessions	O14787, O14655	Gene names	TNPO2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

TNPO2_MOUSE
θ value	0 (rank : 4)	NC score	0.994017 (rank : 3)
Query Neighborhood Hits	64	Target Neighborhood Hits	47	Shared Neighborhood Hits	42
SwissProt Accessions	Q99LG2, Q8C0U9	Gene names	Tnpo2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

IMB1_MOUSE
θ value	8.93572e-24 (rank : 5)	NC score	0.627292 (rank : 6)
Query Neighborhood Hits	64	Target Neighborhood Hits	51	Shared Neighborhood Hits	25
SwissProt Accessions	P70168, Q62117	Gene names	Kpnb1, Impnb
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG).

IMB1_HUMAN
θ value	1.99067e-23 (rank : 6)	NC score	0.628869 (rank : 5)
Query Neighborhood Hits	64	Target Neighborhood Hits	51	Shared Neighborhood Hits	24
SwissProt Accessions	Q14974, Q14637, Q96J27	Gene names	KPNB1, NTF97
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90).

IMB3_HUMAN
θ value	3.52202e-12 (rank : 7)	NC score	0.426008 (rank : 8)
Query Neighborhood Hits	64	Target Neighborhood Hits	57	Shared Neighborhood Hits	26
SwissProt Accessions	O00410, O15257	Gene names	RANBP5, KPNB3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

IMB3_MOUSE
θ value	6.00763e-12 (rank : 8)	NC score	0.427524 (rank : 7)
Query Neighborhood Hits	64	Target Neighborhood Hits	58	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BKC5, Q3TEG2, Q7TQC6, Q9EQ30	Gene names	Ranbp5, Kpnb3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

RNBP6_HUMAN
θ value	2.98157e-11 (rank : 9)	NC score	0.417777 (rank : 9)
Query Neighborhood Hits	64	Target Neighborhood Hits	31	Shared Neighborhood Hits	15
SwissProt Accessions	O60518, Q5T7X4, Q7Z3V2, Q96E78	Gene names	RANBP6
Domain Architecture	No domain graphic available
Description	Ran-binding protein 6 (RanBP6).

XPO2_HUMAN
θ value	9.92553e-07 (rank : 10)	NC score	0.267764 (rank : 12)
Query Neighborhood Hits	64	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	P55060, O75432, Q32M40, Q9H5B7, Q9NTS0, Q9UP98, Q9UP99, Q9UPA0	Gene names	CSE1L, CAS, XPO2
Domain Architecture
Description	Exportin-2 (Exp2) (Importin-alpha re-exporter) (Chromosome segregation 1-like protein) (Cellular apoptosis susceptibility protein).

XPO2_MOUSE
θ value	9.92553e-07 (rank : 11)	NC score	0.266409 (rank : 13)
Query Neighborhood Hits	64	Target Neighborhood Hits	27	Shared Neighborhood Hits	15
SwissProt Accessions	Q9ERK4	Gene names	Cse1l, Xpo2
Domain Architecture
Description	Exportin-2 (Exp2) (Importin-alpha re-exporter) (Chromosome segregation 1-like protein).

IPO4_HUMAN
θ value	6.43352e-06 (rank : 12)	NC score	0.342542 (rank : 10)
Query Neighborhood Hits	64	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TEX9, Q86TZ9, Q8NCG8, Q96SJ3, Q9BTI4, Q9H5L0	Gene names	IPO4, IMP4B, RANBP4
Domain Architecture
Description	Importin-4 (Importin 4b) (Imp4b) (Ran-binding protein 4) (RanBP4).

IPO11_MOUSE
θ value	7.1131e-05 (rank : 13)	NC score	0.258688 (rank : 14)
Query Neighborhood Hits	64	Target Neighborhood Hits	32	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K2V6, Q8BU45, Q8K0B4	Gene names	Ipo11, Ranbp11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

IPO11_HUMAN
θ value	9.29e-05 (rank : 14)	NC score	0.258521 (rank : 15)
Query Neighborhood Hits	64	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UI26, Q8N5R2, Q9NSJ6, Q9NVB1	Gene names	IPO11, RANBP11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

IPO4_MOUSE
θ value	0.000121331 (rank : 15)	NC score	0.335735 (rank : 11)
Query Neighborhood Hits	64	Target Neighborhood Hits	44	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VI75, Q3TBW0, Q99J52	Gene names	Ipo4, Imp4a, Ranbp4
Domain Architecture	No domain graphic available
Description	Importin-4 (Importin 4a) (Imp4a) (Ran-binding protein 4) (RanBP4).

ECM29_HUMAN
θ value	0.00390308 (rank : 16)	NC score	0.163743 (rank : 20)
Query Neighborhood Hits	64	Target Neighborhood Hits	46	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VYK3, O15074, Q8WU82	Gene names	ECM29, KIAA0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

ECM29_MOUSE
θ value	0.00390308 (rank : 17)	NC score	0.167198 (rank : 19)
Query Neighborhood Hits	64	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6	Gene names	Ecm29, Kiaa0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

IPO9_HUMAN
θ value	0.00390308 (rank : 18)	NC score	0.224878 (rank : 16)
Query Neighborhood Hits	64	Target Neighborhood Hits	28	Shared Neighborhood Hits	12
SwissProt Accessions	Q96P70, Q8N1Y1, Q8N3I2, Q8NCG9, Q96SU6, Q9NW01, Q9P0A8, Q9ULM8	Gene names	IPO9, IMP9, KIAA1192, RANBP9
Domain Architecture
Description	Importin-9 (Imp9) (Ran-binding protein 9) (RanbP9).

IPO9_MOUSE
θ value	0.00390308 (rank : 19)	NC score	0.224180 (rank : 17)
Query Neighborhood Hits	64	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q91YE6, Q924M3, Q924M4	Gene names	Ipo9, Imp9, Ranbp9
Domain Architecture
Description	Importin-9 (Importin 9a) (Imp9a) (Importin 9b) (Imp9b) (Ran-binding protein 9) (RanBP9).

PP4RL_HUMAN
θ value	0.0113563 (rank : 20)	NC score	0.086644 (rank : 36)
Query Neighborhood Hits	64	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P1A2, Q9BZ17, Q9BZ18	Gene names	PPP4R1L, C20orf192
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1-like.

IMA7_MOUSE
θ value	0.0252991 (rank : 21)	NC score	0.123006 (rank : 25)
Query Neighborhood Hits	64	Target Neighborhood Hits	50	Shared Neighborhood Hits	13
SwissProt Accessions	O35345, Q9CVP9	Gene names	Kpna6, Kpna5
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6 subunit) (Importin alpha S2).

IMA7_HUMAN
θ value	0.0330416 (rank : 22)	NC score	0.125689 (rank : 22)
Query Neighborhood Hits	64	Target Neighborhood Hits	50	Shared Neighborhood Hits	15
SwissProt Accessions	O60684	Gene names	KPNA6, IPOA7
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6).

2AAA_MOUSE
θ value	0.0563607 (rank : 23)	NC score	0.111645 (rank : 28)
Query Neighborhood Hits	64	Target Neighborhood Hits	41	Shared Neighborhood Hits	19
SwissProt Accessions	Q76MZ3	Gene names	Ppp2r1a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform).

IMA5_HUMAN
θ value	0.0563607 (rank : 24)	NC score	0.099123 (rank : 33)
Query Neighborhood Hits	64	Target Neighborhood Hits	68	Shared Neighborhood Hits	15
SwissProt Accessions	O15131	Gene names	KPNA5
Domain Architecture
Description	Importin alpha-6 subunit (Karyopherin alpha-5 subunit).

IMA3_MOUSE
θ value	0.0736092 (rank : 25)	NC score	0.106302 (rank : 29)
Query Neighborhood Hits	64	Target Neighborhood Hits	56	Shared Neighborhood Hits	15
SwissProt Accessions	O35344	Gene names	Kpna3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (Importin alpha Q2).

IMA4_HUMAN
θ value	0.0736092 (rank : 26)	NC score	0.118937 (rank : 27)
Query Neighborhood Hits	64	Target Neighborhood Hits	59	Shared Neighborhood Hits	16
SwissProt Accessions	O00629, O00190	Gene names	KPNA4, QIP1
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Qip1 protein).

IMA4_MOUSE
θ value	0.0736092 (rank : 27)	NC score	0.120712 (rank : 26)
Query Neighborhood Hits	64	Target Neighborhood Hits	60	Shared Neighborhood Hits	16
SwissProt Accessions	O35343	Gene names	Kpna4
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Importin alpha Q1).

XPO1_HUMAN
θ value	0.0961366 (rank : 28)	NC score	0.123969 (rank : 24)
Query Neighborhood Hits	64	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	O14980, Q63HP8, Q68CP3, Q99433	Gene names	XPO1, CRM1
Domain Architecture	No domain graphic available
Description	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog).

XPO1_MOUSE
θ value	0.0961366 (rank : 29)	NC score	0.124795 (rank : 23)
Query Neighborhood Hits	64	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P5F9	Gene names	Xpo1, Crm1
Domain Architecture	No domain graphic available
Description	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog).

PMF1_MOUSE
θ value	0.125558 (rank : 30)	NC score	0.167530 (rank : 18)
Query Neighborhood Hits	64	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CPV5, Q3UCB8, Q8K237, Q924B3, Q9D6E2	Gene names	Pmf1
Domain Architecture	No domain graphic available
Description	Polyamine-modulated factor 1 (PMF-1).

2AAA_HUMAN
θ value	0.279714 (rank : 31)	NC score	0.103200 (rank : 30)
Query Neighborhood Hits	64	Target Neighborhood Hits	42	Shared Neighborhood Hits	19
SwissProt Accessions	P30153, Q13773	Gene names	PPP2R1A
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform) (Medium tumor antigen-associated 61 kDa protein).

2AAB_MOUSE
θ value	0.279714 (rank : 32)	NC score	0.102108 (rank : 32)
Query Neighborhood Hits	64	Target Neighborhood Hits	36	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TNP2	Gene names	Ppp2r1b
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

CKAP5_HUMAN
θ value	0.279714 (rank : 33)	NC score	0.066041 (rank : 41)
Query Neighborhood Hits	64	Target Neighborhood Hits	96	Shared Neighborhood Hits	7
SwissProt Accessions	Q14008, Q14668	Gene names	CKAP5, KIAA0097
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 5 (Colonic and hepatic tumor over- expressed protein) (Ch-TOG protein).

IMA3_HUMAN
θ value	0.365318 (rank : 34)	NC score	0.094476 (rank : 34)
Query Neighborhood Hits	64	Target Neighborhood Hits	53	Shared Neighborhood Hits	13
SwissProt Accessions	O00505, O00191, O43195, Q96AA7	Gene names	KPNA3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (SRP1-gamma).

AP4E1_HUMAN
θ value	0.47712 (rank : 35)	NC score	0.061008 (rank : 44)
Query Neighborhood Hits	64	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

FRAP_HUMAN
θ value	0.47712 (rank : 36)	NC score	0.061326 (rank : 43)
Query Neighborhood Hits	64	Target Neighborhood Hits	83	Shared Neighborhood Hits	15
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_MOUSE
θ value	0.47712 (rank : 37)	NC score	0.060893 (rank : 46)
Query Neighborhood Hits	64	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

GCN1L_HUMAN
θ value	0.47712 (rank : 38)	NC score	0.129814 (rank : 21)
Query Neighborhood Hits	64	Target Neighborhood Hits	112	Shared Neighborhood Hits	32
SwissProt Accessions	Q92616, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60	Gene names	GCN1L1, KIAA0219
Domain Architecture	No domain graphic available
Description	GCN1-like protein 1 (HsGCN1).

AP4E1_MOUSE
θ value	0.62314 (rank : 39)	NC score	0.058544 (rank : 48)
Query Neighborhood Hits	64	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

PODO_MOUSE
θ value	0.62314 (rank : 40)	NC score	0.033895 (rank : 58)
Query Neighborhood Hits	64	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q91X05, Q8BWE6, Q91Z95	Gene names	Nphs2
Domain Architecture
Description	Podocin.

MMS19_MOUSE
θ value	0.813845 (rank : 41)	NC score	0.055041 (rank : 51)
Query Neighborhood Hits	64	Target Neighborhood Hits	19	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D071, Q925N8, Q9CWX3	Gene names	Mms19l, Mms19
Domain Architecture	No domain graphic available
Description	MMS19-like protein (MET18 homolog).

CAND2_MOUSE
θ value	1.06291 (rank : 42)	NC score	0.061653 (rank : 42)
Query Neighborhood Hits	64	Target Neighborhood Hits	44	Shared Neighborhood Hits	15
SwissProt Accessions	Q6ZQ73, Q6PHT7	Gene names	Cand2, Kiaa0667, Tip120b
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2) (TBP-interacting protein TIP120B) (TBP-interacting protein of 120 kDa B).

MMS19_HUMAN
θ value	1.38821 (rank : 43)	NC score	0.052135 (rank : 53)
Query Neighborhood Hits	64	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	Q96T76, Q5T455, Q66K82, Q7L4W8, Q969Z1, Q96DF1, Q96MR1, Q96RK5, Q96SK1, Q9BUE2, Q9BYS9	Gene names	MMS19L, MMS19
Domain Architecture	No domain graphic available
Description	MMS19-like protein (hMMS19) (MET18 homolog).

RPTOR_MOUSE
θ value	1.38821 (rank : 44)	NC score	0.042107 (rank : 56)
Query Neighborhood Hits	64	Target Neighborhood Hits	129	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K4Q0, Q8C9W9, Q8CBY4, Q8CDY8, Q9D4H3	Gene names	Raptor
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

BTAF1_HUMAN
θ value	1.81305 (rank : 45)	NC score	0.032968 (rank : 59)
Query Neighborhood Hits	64	Target Neighborhood Hits	97	Shared Neighborhood Hits	14
SwissProt Accessions	O14981, O43578	Gene names	BTAF1, TAF172
Domain Architecture
Description	TATA-binding protein-associated factor 172 (EC 3.6.1.-) (ATP-dependent helicase BTAF1) (TBP-associated factor 172) (TAF-172) (TAF(II)170) (B- TFIID transcription factor-associated 170 kDa subunit).

RPTOR_HUMAN
θ value	1.81305 (rank : 46)	NC score	0.042780 (rank : 55)
Query Neighborhood Hits	64	Target Neighborhood Hits	121	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N122, Q8N4V9, Q8TB32, Q9P2P3	Gene names	RAPTOR, KIAA1303
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

HEAT2_HUMAN
θ value	2.36792 (rank : 47)	NC score	0.102646 (rank : 31)
Query Neighborhood Hits	64	Target Neighborhood Hits	36	Shared Neighborhood Hits	19
SwissProt Accessions	Q86Y56, Q69YL1, Q96FI9, Q9NX75	Gene names	HEATR2
Domain Architecture	No domain graphic available
Description	HEAT repeat-containing protein 2.

K0406_HUMAN
θ value	2.36792 (rank : 48)	NC score	0.023771 (rank : 62)
Query Neighborhood Hits	64	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	O43156, Q5JX67, Q96A38, Q9BR47, Q9H4K0	Gene names	KIAA0406
Domain Architecture	No domain graphic available
Description	Protein KIAA0406.

SF3B1_HUMAN
θ value	2.36792 (rank : 49)	NC score	0.066639 (rank : 39)
Query Neighborhood Hits	64	Target Neighborhood Hits	341	Shared Neighborhood Hits	18
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
θ value	2.36792 (rank : 50)	NC score	0.067235 (rank : 38)
Query Neighborhood Hits	64	Target Neighborhood Hits	352	Shared Neighborhood Hits	19
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

ECE1_MOUSE
θ value	3.0926 (rank : 51)	NC score	0.013297 (rank : 65)
Query Neighborhood Hits	64	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

GHR_HUMAN
θ value	4.03905 (rank : 52)	NC score	0.024723 (rank : 61)
Query Neighborhood Hits	64	Target Neighborhood Hits	57	Shared Neighborhood Hits	4
SwissProt Accessions	P10912, Q9HCX2	Gene names	GHR
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].

INADL_HUMAN
θ value	4.03905 (rank : 53)	NC score	0.009029 (rank : 68)
Query Neighborhood Hits	64	Target Neighborhood Hits	260	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

PKP3_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.034274 (rank : 57)
Query Neighborhood Hits	64	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y446	Gene names	PKP3
Domain Architecture
Description	Plakophilin-3.

PKP3_MOUSE
θ value	4.03905 (rank : 55)	NC score	0.029301 (rank : 60)
Query Neighborhood Hits	64	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QY23	Gene names	Pkp3
Domain Architecture
Description	Plakophilin-3.

PTK6_MOUSE
θ value	5.27518 (rank : 56)	NC score	-0.000964 (rank : 72)
Query Neighborhood Hits	64	Target Neighborhood Hits	1026	Shared Neighborhood Hits	3
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

TAXB1_MOUSE
θ value	5.27518 (rank : 57)	NC score	0.005464 (rank : 69)
Query Neighborhood Hits	64	Target Neighborhood Hits	886	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

CAND2_HUMAN
θ value	6.88961 (rank : 58)	NC score	0.057725 (rank : 49)
Query Neighborhood Hits	64	Target Neighborhood Hits	40	Shared Neighborhood Hits	19
SwissProt Accessions	O75155	Gene names	CAND2, KIAA0667
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2).

GPR98_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.009109 (rank : 67)
Query Neighborhood Hits	64	Target Neighborhood Hits	202	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WXG9, O75171, Q9H0X5, Q9UL61	Gene names	GPR98, KIAA0686, MASS1, VLGR1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Usher syndrome type-2C protein).

GSDM1_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.015600 (rank : 64)
Query Neighborhood Hits	64	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q96QA5, Q8N1M6	Gene names	GSDM1, GSDM
Domain Architecture	No domain graphic available
Description	Gasdermin.

IFIH1_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.009875 (rank : 66)
Query Neighborhood Hits	64	Target Neighborhood Hits	96	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

LEO1_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.002535 (rank : 70)
Query Neighborhood Hits	64	Target Neighborhood Hits	958	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

K0406_MOUSE
θ value	8.99809 (rank : 63)	NC score	0.019188 (rank : 63)
Query Neighborhood Hits	64	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	Q91V83, Q9CSY0	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA0406 homolog.

PTPRU_HUMAN
θ value	8.99809 (rank : 64)	NC score	0.001440 (rank : 71)
Query Neighborhood Hits	64	Target Neighborhood Hits	237	Shared Neighborhood Hits	2
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

2AAB_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.087799 (rank : 35)
Query Neighborhood Hits	64	Target Neighborhood Hits	37	Shared Neighborhood Hits	14
SwissProt Accessions	P30154, O75620	Gene names	PPP2R1B
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

IMA1_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.066225 (rank : 40)
Query Neighborhood Hits	64	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	P52294, Q9BQ56	Gene names	KPNA1, RCH2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (NPI-1).

IMA1_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.067245 (rank : 37)
Query Neighborhood Hits	64	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q60960, Q3TF32	Gene names	Kpna1, Rch2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (Importin alpha S1).

IMA2_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.060912 (rank : 45)
Query Neighborhood Hits	64	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	P52292, Q9BRU5	Gene names	KPNA2, RCH1, SRP1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1).

IMA2_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.060355 (rank : 47)
Query Neighborhood Hits	64	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	P52293, Q64292	Gene names	Kpna2, Rch1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) (Pendulin) (Pore targeting complex 58 kDa subunit) (PTAC58) (Importin alpha P1).

IPO8_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.052385 (rank : 52)
Query Neighborhood Hits	64	Target Neighborhood Hits	35	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TMY7, Q811I3, Q8C8A9, Q8R2P6, Q8R3V7	Gene names	Ipo8
Domain Architecture
Description	Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8).

SPAG6_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.051620 (rank : 54)
Query Neighborhood Hits	64	Target Neighborhood Hits	58	Shared Neighborhood Hits	17
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

SPAG6_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.056302 (rank : 50)
Query Neighborhood Hits	64	Target Neighborhood Hits	62	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JLI7, Q8K461	Gene names	Spag6, Pf16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Axoneme central apparatus protein).

Hits sorted by NC score

TNPO1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	64	Target Neighborhood Hits	64	Shared Neighborhood Hits	64
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

TNPO1_MOUSE
NC score	0.999500 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	64	Target Neighborhood Hits	63	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

TNPO2_MOUSE
NC score	0.994017 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	64	Target Neighborhood Hits	47	Shared Neighborhood Hits	42
SwissProt Accessions	Q99LG2, Q8C0U9	Gene names	Tnpo2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

TNPO2_HUMAN
NC score	0.993483 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	64	Target Neighborhood Hits	47	Shared Neighborhood Hits	42
SwissProt Accessions	O14787, O14655	Gene names	TNPO2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

IMB1_HUMAN
NC score	0.628869 (rank : 5)	θ value	1.99067e-23 (rank : 6)
Query Neighborhood Hits	64	Target Neighborhood Hits	51	Shared Neighborhood Hits	24
SwissProt Accessions	Q14974, Q14637, Q96J27	Gene names	KPNB1, NTF97
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90).

IMB1_MOUSE
NC score	0.627292 (rank : 6)	θ value	8.93572e-24 (rank : 5)
Query Neighborhood Hits	64	Target Neighborhood Hits	51	Shared Neighborhood Hits	25
SwissProt Accessions	P70168, Q62117	Gene names	Kpnb1, Impnb
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG).

IMB3_MOUSE
NC score	0.427524 (rank : 7)	θ value	6.00763e-12 (rank : 8)
Query Neighborhood Hits	64	Target Neighborhood Hits	58	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BKC5, Q3TEG2, Q7TQC6, Q9EQ30	Gene names	Ranbp5, Kpnb3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

IMB3_HUMAN
NC score	0.426008 (rank : 8)	θ value	3.52202e-12 (rank : 7)
Query Neighborhood Hits	64	Target Neighborhood Hits	57	Shared Neighborhood Hits	26
SwissProt Accessions	O00410, O15257	Gene names	RANBP5, KPNB3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

RNBP6_HUMAN
NC score	0.417777 (rank : 9)	θ value	2.98157e-11 (rank : 9)
Query Neighborhood Hits	64	Target Neighborhood Hits	31	Shared Neighborhood Hits	15
SwissProt Accessions	O60518, Q5T7X4, Q7Z3V2, Q96E78	Gene names	RANBP6
Domain Architecture	No domain graphic available
Description	Ran-binding protein 6 (RanBP6).

IPO4_HUMAN
NC score	0.342542 (rank : 10)	θ value	6.43352e-06 (rank : 12)
Query Neighborhood Hits	64	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TEX9, Q86TZ9, Q8NCG8, Q96SJ3, Q9BTI4, Q9H5L0	Gene names	IPO4, IMP4B, RANBP4
Domain Architecture
Description	Importin-4 (Importin 4b) (Imp4b) (Ran-binding protein 4) (RanBP4).

IPO4_MOUSE
NC score	0.335735 (rank : 11)	θ value	0.000121331 (rank : 15)
Query Neighborhood Hits	64	Target Neighborhood Hits	44	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VI75, Q3TBW0, Q99J52	Gene names	Ipo4, Imp4a, Ranbp4
Domain Architecture	No domain graphic available
Description	Importin-4 (Importin 4a) (Imp4a) (Ran-binding protein 4) (RanBP4).

XPO2_HUMAN
NC score	0.267764 (rank : 12)	θ value	9.92553e-07 (rank : 10)
Query Neighborhood Hits	64	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	P55060, O75432, Q32M40, Q9H5B7, Q9NTS0, Q9UP98, Q9UP99, Q9UPA0	Gene names	CSE1L, CAS, XPO2
Domain Architecture
Description	Exportin-2 (Exp2) (Importin-alpha re-exporter) (Chromosome segregation 1-like protein) (Cellular apoptosis susceptibility protein).

XPO2_MOUSE
NC score	0.266409 (rank : 13)	θ value	9.92553e-07 (rank : 11)
Query Neighborhood Hits	64	Target Neighborhood Hits	27	Shared Neighborhood Hits	15
SwissProt Accessions	Q9ERK4	Gene names	Cse1l, Xpo2
Domain Architecture
Description	Exportin-2 (Exp2) (Importin-alpha re-exporter) (Chromosome segregation 1-like protein).

IPO11_MOUSE
NC score	0.258688 (rank : 14)	θ value	7.1131e-05 (rank : 13)
Query Neighborhood Hits	64	Target Neighborhood Hits	32	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K2V6, Q8BU45, Q8K0B4	Gene names	Ipo11, Ranbp11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

IPO11_HUMAN
NC score	0.258521 (rank : 15)	θ value	9.29e-05 (rank : 14)
Query Neighborhood Hits	64	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UI26, Q8N5R2, Q9NSJ6, Q9NVB1	Gene names	IPO11, RANBP11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

IPO9_HUMAN
NC score	0.224878 (rank : 16)	θ value	0.00390308 (rank : 18)
Query Neighborhood Hits	64	Target Neighborhood Hits	28	Shared Neighborhood Hits	12
SwissProt Accessions	Q96P70, Q8N1Y1, Q8N3I2, Q8NCG9, Q96SU6, Q9NW01, Q9P0A8, Q9ULM8	Gene names	IPO9, IMP9, KIAA1192, RANBP9
Domain Architecture
Description	Importin-9 (Imp9) (Ran-binding protein 9) (RanbP9).

IPO9_MOUSE
NC score	0.224180 (rank : 17)	θ value	0.00390308 (rank : 19)
Query Neighborhood Hits	64	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q91YE6, Q924M3, Q924M4	Gene names	Ipo9, Imp9, Ranbp9
Domain Architecture
Description	Importin-9 (Importin 9a) (Imp9a) (Importin 9b) (Imp9b) (Ran-binding protein 9) (RanBP9).

PMF1_MOUSE
NC score	0.167530 (rank : 18)	θ value	0.125558 (rank : 30)
Query Neighborhood Hits	64	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CPV5, Q3UCB8, Q8K237, Q924B3, Q9D6E2	Gene names	Pmf1
Domain Architecture	No domain graphic available
Description	Polyamine-modulated factor 1 (PMF-1).

ECM29_MOUSE
NC score	0.167198 (rank : 19)	θ value	0.00390308 (rank : 17)
Query Neighborhood Hits	64	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6	Gene names	Ecm29, Kiaa0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

ECM29_HUMAN
NC score	0.163743 (rank : 20)	θ value	0.00390308 (rank : 16)
Query Neighborhood Hits	64	Target Neighborhood Hits	46	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VYK3, O15074, Q8WU82	Gene names	ECM29, KIAA0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

GCN1L_HUMAN
NC score	0.129814 (rank : 21)	θ value	0.47712 (rank : 38)
Query Neighborhood Hits	64	Target Neighborhood Hits	112	Shared Neighborhood Hits	32
SwissProt Accessions	Q92616, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60	Gene names	GCN1L1, KIAA0219
Domain Architecture	No domain graphic available
Description	GCN1-like protein 1 (HsGCN1).

IMA7_HUMAN
NC score	0.125689 (rank : 22)	θ value	0.0330416 (rank : 22)
Query Neighborhood Hits	64	Target Neighborhood Hits	50	Shared Neighborhood Hits	15
SwissProt Accessions	O60684	Gene names	KPNA6, IPOA7
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6).

XPO1_MOUSE
NC score	0.124795 (rank : 23)	θ value	0.0961366 (rank : 29)
Query Neighborhood Hits	64	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P5F9	Gene names	Xpo1, Crm1
Domain Architecture	No domain graphic available
Description	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog).

XPO1_HUMAN
NC score	0.123969 (rank : 24)	θ value	0.0961366 (rank : 28)
Query Neighborhood Hits	64	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	O14980, Q63HP8, Q68CP3, Q99433	Gene names	XPO1, CRM1
Domain Architecture	No domain graphic available
Description	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog).

IMA7_MOUSE
NC score	0.123006 (rank : 25)	θ value	0.0252991 (rank : 21)
Query Neighborhood Hits	64	Target Neighborhood Hits	50	Shared Neighborhood Hits	13
SwissProt Accessions	O35345, Q9CVP9	Gene names	Kpna6, Kpna5
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6 subunit) (Importin alpha S2).

IMA4_MOUSE
NC score	0.120712 (rank : 26)	θ value	0.0736092 (rank : 27)
Query Neighborhood Hits	64	Target Neighborhood Hits	60	Shared Neighborhood Hits	16
SwissProt Accessions	O35343	Gene names	Kpna4
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Importin alpha Q1).

IMA4_HUMAN
NC score	0.118937 (rank : 27)	θ value	0.0736092 (rank : 26)
Query Neighborhood Hits	64	Target Neighborhood Hits	59	Shared Neighborhood Hits	16
SwissProt Accessions	O00629, O00190	Gene names	KPNA4, QIP1
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Qip1 protein).

2AAA_MOUSE
NC score	0.111645 (rank : 28)	θ value	0.0563607 (rank : 23)
Query Neighborhood Hits	64	Target Neighborhood Hits	41	Shared Neighborhood Hits	19
SwissProt Accessions	Q76MZ3	Gene names	Ppp2r1a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform).

IMA3_MOUSE
NC score	0.106302 (rank : 29)	θ value	0.0736092 (rank : 25)
Query Neighborhood Hits	64	Target Neighborhood Hits	56	Shared Neighborhood Hits	15
SwissProt Accessions	O35344	Gene names	Kpna3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (Importin alpha Q2).

2AAA_HUMAN
NC score	0.103200 (rank : 30)	θ value	0.279714 (rank : 31)
Query Neighborhood Hits	64	Target Neighborhood Hits	42	Shared Neighborhood Hits	19
SwissProt Accessions	P30153, Q13773	Gene names	PPP2R1A
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform) (Medium tumor antigen-associated 61 kDa protein).

HEAT2_HUMAN
NC score	0.102646 (rank : 31)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	64	Target Neighborhood Hits	36	Shared Neighborhood Hits	19
SwissProt Accessions	Q86Y56, Q69YL1, Q96FI9, Q9NX75	Gene names	HEATR2
Domain Architecture	No domain graphic available
Description	HEAT repeat-containing protein 2.

2AAB_MOUSE
NC score	0.102108 (rank : 32)	θ value	0.279714 (rank : 32)
Query Neighborhood Hits	64	Target Neighborhood Hits	36	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TNP2	Gene names	Ppp2r1b
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

IMA5_HUMAN
NC score	0.099123 (rank : 33)	θ value	0.0563607 (rank : 24)
Query Neighborhood Hits	64	Target Neighborhood Hits	68	Shared Neighborhood Hits	15
SwissProt Accessions	O15131	Gene names	KPNA5
Domain Architecture
Description	Importin alpha-6 subunit (Karyopherin alpha-5 subunit).

IMA3_HUMAN
NC score	0.094476 (rank : 34)	θ value	0.365318 (rank : 34)
Query Neighborhood Hits	64	Target Neighborhood Hits	53	Shared Neighborhood Hits	13
SwissProt Accessions	O00505, O00191, O43195, Q96AA7	Gene names	KPNA3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (SRP1-gamma).

2AAB_HUMAN
NC score	0.087799 (rank : 35)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	64	Target Neighborhood Hits	37	Shared Neighborhood Hits	14
SwissProt Accessions	P30154, O75620	Gene names	PPP2R1B
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

PP4RL_HUMAN
NC score	0.086644 (rank : 36)	θ value	0.0113563 (rank : 20)
Query Neighborhood Hits	64	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P1A2, Q9BZ17, Q9BZ18	Gene names	PPP4R1L, C20orf192
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1-like.

IMA1_MOUSE
NC score	0.067245 (rank : 37)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	64	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q60960, Q3TF32	Gene names	Kpna1, Rch2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (Importin alpha S1).

SF3B1_MOUSE
NC score	0.067235 (rank : 38)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	64	Target Neighborhood Hits	352	Shared Neighborhood Hits	19
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_HUMAN
NC score	0.066639 (rank : 39)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	64	Target Neighborhood Hits	341	Shared Neighborhood Hits	18
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

IMA1_HUMAN
NC score	0.066225 (rank : 40)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	64	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	P52294, Q9BQ56	Gene names	KPNA1, RCH2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (NPI-1).

CKAP5_HUMAN
NC score	0.066041 (rank : 41)	θ value	0.279714 (rank : 33)
Query Neighborhood Hits	64	Target Neighborhood Hits	96	Shared Neighborhood Hits	7
SwissProt Accessions	Q14008, Q14668	Gene names	CKAP5, KIAA0097
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 5 (Colonic and hepatic tumor over- expressed protein) (Ch-TOG protein).

CAND2_MOUSE
NC score	0.061653 (rank : 42)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	64	Target Neighborhood Hits	44	Shared Neighborhood Hits	15
SwissProt Accessions	Q6ZQ73, Q6PHT7	Gene names	Cand2, Kiaa0667, Tip120b
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2) (TBP-interacting protein TIP120B) (TBP-interacting protein of 120 kDa B).

FRAP_HUMAN
NC score	0.061326 (rank : 43)	θ value	0.47712 (rank : 36)
Query Neighborhood Hits	64	Target Neighborhood Hits	83	Shared Neighborhood Hits	15
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

AP4E1_HUMAN
NC score	0.061008 (rank : 44)	θ value	0.47712 (rank : 35)
Query Neighborhood Hits	64	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

IMA2_HUMAN
NC score	0.060912 (rank : 45)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	64	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	P52292, Q9BRU5	Gene names	KPNA2, RCH1, SRP1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1).

FRAP_MOUSE
NC score	0.060893 (rank : 46)	θ value	0.47712 (rank : 37)
Query Neighborhood Hits	64	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

IMA2_MOUSE
NC score	0.060355 (rank : 47)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	64	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	P52293, Q64292	Gene names	Kpna2, Rch1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) (Pendulin) (Pore targeting complex 58 kDa subunit) (PTAC58) (Importin alpha P1).

AP4E1_MOUSE
NC score	0.058544 (rank : 48)	θ value	0.62314 (rank : 39)
Query Neighborhood Hits	64	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

CAND2_HUMAN
NC score	0.057725 (rank : 49)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	64	Target Neighborhood Hits	40	Shared Neighborhood Hits	19
SwissProt Accessions	O75155	Gene names	CAND2, KIAA0667
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2).

SPAG6_MOUSE
NC score	0.056302 (rank : 50)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	64	Target Neighborhood Hits	62	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JLI7, Q8K461	Gene names	Spag6, Pf16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Axoneme central apparatus protein).

MMS19_MOUSE
NC score	0.055041 (rank : 51)	θ value	0.813845 (rank : 41)
Query Neighborhood Hits	64	Target Neighborhood Hits	19	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D071, Q925N8, Q9CWX3	Gene names	Mms19l, Mms19
Domain Architecture	No domain graphic available
Description	MMS19-like protein (MET18 homolog).

IPO8_MOUSE
NC score	0.052385 (rank : 52)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	64	Target Neighborhood Hits	35	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TMY7, Q811I3, Q8C8A9, Q8R2P6, Q8R3V7	Gene names	Ipo8
Domain Architecture
Description	Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8).

MMS19_HUMAN
NC score	0.052135 (rank : 53)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	64	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	Q96T76, Q5T455, Q66K82, Q7L4W8, Q969Z1, Q96DF1, Q96MR1, Q96RK5, Q96SK1, Q9BUE2, Q9BYS9	Gene names	MMS19L, MMS19
Domain Architecture	No domain graphic available
Description	MMS19-like protein (hMMS19) (MET18 homolog).

SPAG6_HUMAN
NC score	0.051620 (rank : 54)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	64	Target Neighborhood Hits	58	Shared Neighborhood Hits	17
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

RPTOR_HUMAN
NC score	0.042780 (rank : 55)	θ value	1.81305 (rank : 46)
Query Neighborhood Hits	64	Target Neighborhood Hits	121	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N122, Q8N4V9, Q8TB32, Q9P2P3	Gene names	RAPTOR, KIAA1303
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

RPTOR_MOUSE
NC score	0.042107 (rank : 56)	θ value	1.38821 (rank : 44)
Query Neighborhood Hits	64	Target Neighborhood Hits	129	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K4Q0, Q8C9W9, Q8CBY4, Q8CDY8, Q9D4H3	Gene names	Raptor
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

PKP3_HUMAN
NC score	0.034274 (rank : 57)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	64	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y446	Gene names	PKP3
Domain Architecture
Description	Plakophilin-3.

PODO_MOUSE
NC score	0.033895 (rank : 58)	θ value	0.62314 (rank : 40)
Query Neighborhood Hits	64	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q91X05, Q8BWE6, Q91Z95	Gene names	Nphs2
Domain Architecture
Description	Podocin.

BTAF1_HUMAN
NC score	0.032968 (rank : 59)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	64	Target Neighborhood Hits	97	Shared Neighborhood Hits	14
SwissProt Accessions	O14981, O43578	Gene names	BTAF1, TAF172
Domain Architecture
Description	TATA-binding protein-associated factor 172 (EC 3.6.1.-) (ATP-dependent helicase BTAF1) (TBP-associated factor 172) (TAF-172) (TAF(II)170) (B- TFIID transcription factor-associated 170 kDa subunit).

PKP3_MOUSE
NC score	0.029301 (rank : 60)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	64	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QY23	Gene names	Pkp3
Domain Architecture
Description	Plakophilin-3.

GHR_HUMAN
NC score	0.024723 (rank : 61)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	64	Target Neighborhood Hits	57	Shared Neighborhood Hits	4
SwissProt Accessions	P10912, Q9HCX2	Gene names	GHR
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].

K0406_HUMAN
NC score	0.023771 (rank : 62)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	64	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	O43156, Q5JX67, Q96A38, Q9BR47, Q9H4K0	Gene names	KIAA0406
Domain Architecture	No domain graphic available
Description	Protein KIAA0406.

K0406_MOUSE
NC score	0.019188 (rank : 63)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	64	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	Q91V83, Q9CSY0	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA0406 homolog.

GSDM1_HUMAN
NC score	0.015600 (rank : 64)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	64	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q96QA5, Q8N1M6	Gene names	GSDM1, GSDM
Domain Architecture	No domain graphic available
Description	Gasdermin.

ECE1_MOUSE
NC score	0.013297 (rank : 65)	θ value	3.0926 (rank : 51)
Query Neighborhood Hits	64	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

IFIH1_HUMAN
NC score	0.009875 (rank : 66)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	64	Target Neighborhood Hits	96	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

GPR98_HUMAN
NC score	0.009109 (rank : 67)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	64	Target Neighborhood Hits	202	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WXG9, O75171, Q9H0X5, Q9UL61	Gene names	GPR98, KIAA0686, MASS1, VLGR1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Usher syndrome type-2C protein).

INADL_HUMAN
NC score	0.009029 (rank : 68)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	64	Target Neighborhood Hits	260	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

TAXB1_MOUSE
NC score	0.005464 (rank : 69)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	64	Target Neighborhood Hits	886	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

LEO1_HUMAN
NC score	0.002535 (rank : 70)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	64	Target Neighborhood Hits	958	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

PTPRU_HUMAN
NC score	0.001440 (rank : 71)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	64	Target Neighborhood Hits	237	Shared Neighborhood Hits	2
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTK6_MOUSE
NC score	-0.000964 (rank : 72)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	64	Target Neighborhood Hits	1026	Shared Neighborhood Hits	3
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).