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Network neighborhood for query Sequence : PKP3_HUMAN

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PKP3_HUMAN
SwissProt Accessions	Q9Y446	Gene names	PKP3
Domain Architecture
Description	Plakophilin-3.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PKP3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y446	Gene names	PKP3
Domain Architecture
Description	Plakophilin-3.

PKP3_MOUSE
θ value	0 (rank : 2)	NC score	0.997772 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QY23	Gene names	Pkp3
Domain Architecture
Description	Plakophilin-3.

PKP1_MOUSE
θ value	9.11921e-69 (rank : 3)	NC score	0.928069 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	37	Shared Neighborhood Hits	21
SwissProt Accessions	P97350	Gene names	Pkp1
Domain Architecture
Description	Plakophilin-1.

PKP4_MOUSE
θ value	2.93355e-67 (rank : 4)	NC score	0.901271 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	129	Shared Neighborhood Hits	24
SwissProt Accessions	Q68FH0, Q640N0, Q68G56, Q8BK47, Q8BVH1, Q9CRE3	Gene names	Pkp4, Armrp
Domain Architecture	No domain graphic available
Description	Plakophilin-4 (Armadillo-related protein).

CTND2_HUMAN
θ value	1.2325e-65 (rank : 5)	NC score	0.876183 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	333	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

PKP1_HUMAN
θ value	2.74572e-65 (rank : 6)	NC score	0.924726 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	Q13835, O00645, Q15152	Gene names	PKP1
Domain Architecture
Description	Plakophilin-1 (Band-6 protein) (B6P).

ARVC_HUMAN
θ value	5.17823e-64 (rank : 7)	NC score	0.910024 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	95	Shared Neighborhood Hits	22
SwissProt Accessions	O00192	Gene names	ARVCF
Domain Architecture
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome.

PKP4_HUMAN
θ value	1.50663e-63 (rank : 8)	NC score	0.898959 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	107	Shared Neighborhood Hits	23
SwissProt Accessions	Q99569	Gene names	PKP4
Domain Architecture
Description	Plakophilin-4 (p0071).

ARVC_MOUSE
θ value	3.35642e-63 (rank : 9)	NC score	0.912157 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	67	Shared Neighborhood Hits	22
SwissProt Accessions	P98203, Q6PGJ6, Q8BQ36, Q8BRF2, Q8C3U7, Q924L2, Q924L3, Q924L4, Q924L5	Gene names	Arvcf
Domain Architecture	No domain graphic available
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog.

CTND1_HUMAN
θ value	2.17557e-62 (rank : 10)	NC score	0.907103 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	67	Shared Neighborhood Hits	23
SwissProt Accessions	O60716, O15088, O60713, O60714, O60715, O60935, Q6RBX8, Q9UP71, Q9UP72, Q9UP73	Gene names	CTNND1, KIAA0384
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

CTND2_MOUSE
θ value	2.17557e-62 (rank : 11)	NC score	0.886555 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	227	Shared Neighborhood Hits	24
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

CTND1_MOUSE
θ value	2.40537e-61 (rank : 12)	NC score	0.907148 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	69	Shared Neighborhood Hits	23
SwissProt Accessions	P30999	Gene names	Ctnnd1, Catns
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

PKP2_HUMAN
θ value	2.25136e-59 (rank : 13)	NC score	0.922607 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	40	Shared Neighborhood Hits	18
SwissProt Accessions	Q99959, Q99960	Gene names	PKP2
Domain Architecture
Description	Plakophilin-2.

PLAK_MOUSE
θ value	0.00175202 (rank : 14)	NC score	0.247546 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	55	Shared Neighborhood Hits	21
SwissProt Accessions	Q02257, Q8CGD3	Gene names	Jup
Domain Architecture	No domain graphic available
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

PLAK_HUMAN
θ value	0.00228821 (rank : 15)	NC score	0.215992 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	53	Shared Neighborhood Hits	21
SwissProt Accessions	P14923, Q9HCX9	Gene names	JUP, DP3
Domain Architecture
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

ARMC4_HUMAN
θ value	0.0113563 (rank : 16)	NC score	0.340242 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	88	Shared Neighborhood Hits	23
SwissProt Accessions	Q5T2S8, Q9H0C0	Gene names	ARMC4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 4.

CTNB1_HUMAN
θ value	0.0252991 (rank : 17)	NC score	0.263681 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	23
SwissProt Accessions	P35222, Q8NEW9, Q8NI94, Q9H391	Gene names	CTNNB1, CTNNB
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

CTNB1_MOUSE
θ value	0.0252991 (rank : 18)	NC score	0.263737 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	50	Shared Neighborhood Hits	23
SwissProt Accessions	Q02248, Q922W1, Q9D335	Gene names	Ctnnb1, Catnb
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

NFKB1_HUMAN
θ value	0.279714 (rank : 19)	NC score	0.017610 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	306	Shared Neighborhood Hits	3
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

TTF1_MOUSE
θ value	0.47712 (rank : 20)	NC score	0.034081 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	277	Shared Neighborhood Hits	4
SwissProt Accessions	Q62187, Q9JKK5	Gene names	Ttf1
Domain Architecture	No domain graphic available
Description	Transcription termination factor 1 (TTF-1) (TTF-I) (mTFF-I) (RNA polymerase I termination factor).

SYNE1_HUMAN
θ value	0.62314 (rank : 21)	NC score	0.010917 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	1484	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

APC_HUMAN
θ value	0.813845 (rank : 22)	NC score	0.174699 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	603	Shared Neighborhood Hits	24
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

APC_MOUSE
θ value	0.813845 (rank : 23)	NC score	0.179797 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	441	Shared Neighborhood Hits	24
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

AXUD1_HUMAN
θ value	1.06291 (rank : 24)	NC score	0.019193 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q96S65	Gene names	AXUD1, TAIP3
Domain Architecture	No domain graphic available
Description	Axin-1 up-regulated gene 1 protein (TGF-beta-induced apoptosis protein 3) (TAIP-3) (URAX1 protein).

SYP2L_MOUSE
θ value	1.06291 (rank : 25)	NC score	0.015835 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	289	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

TNPO2_HUMAN
θ value	1.06291 (rank : 26)	NC score	0.037917 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	47	Shared Neighborhood Hits	7
SwissProt Accessions	O14787, O14655	Gene names	TNPO2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

TNPO2_MOUSE
θ value	1.06291 (rank : 27)	NC score	0.037866 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	47	Shared Neighborhood Hits	7
SwissProt Accessions	Q99LG2, Q8C0U9	Gene names	Tnpo2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

UBE4B_HUMAN
θ value	1.06291 (rank : 28)	NC score	0.020513 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	158	Shared Neighborhood Hits	2
SwissProt Accessions	O95155, O75169, O95338, Q5SZ12, Q5SZ16, Q96QD4, Q9BYI7	Gene names	UBE4B, HDNB1, KIAA0684, UFD2
Domain Architecture
Description	Ubiquitin conjugation factor E4 B (Ubiquitin fusion degradation protein 2) (Homozygously deleted in neuroblastoma 1).

EFNB3_HUMAN
θ value	1.38821 (rank : 29)	NC score	0.016705 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	48	Shared Neighborhood Hits	2
SwissProt Accessions	Q15768, O00680, Q8TBH7, Q92875	Gene names	EFNB3, EPLG8, LERK8
Domain Architecture
Description	Ephrin-B3 precursor (EPH-related receptor tyrosine kinase ligand 8) (LERK-8) (EPH-related receptor transmembrane ligand ELK-L3).

KCNH2_HUMAN
θ value	1.38821 (rank : 30)	NC score	0.008671 (rank : 46)
Query Neighborhood Hits	42	Target Neighborhood Hits	158	Shared Neighborhood Hits	2
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

IMA5_HUMAN
θ value	2.36792 (rank : 31)	NC score	0.069655 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	68	Shared Neighborhood Hits	22
SwissProt Accessions	O15131	Gene names	KPNA5
Domain Architecture
Description	Importin alpha-6 subunit (Karyopherin alpha-5 subunit).

GDS1_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.137208 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	19
SwissProt Accessions	P52306, Q9NYM2, Q9NZA8	Gene names	RAP1GDS1
Domain Architecture
Description	Rap1 GTPase-GDP dissociation stimulator 1 (SMG P21 stimulatory GDP/GTP exchange protein) (SMG GDS protein) (Exchange factor smgGDS).

SMOC2_HUMAN
θ value	4.03905 (rank : 33)	NC score	0.015807 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H3U7, Q5TAT7, Q5TAT8, Q86VV9, Q96SF3, Q9H1L3, Q9H1L4, Q9H3U0, Q9H4F7, Q9HCV2	Gene names	SMOC2, SMAP2
Domain Architecture
Description	SPARC-related modular calcium-binding protein 2 precursor (Secreted modular calcium-binding protein 2) (SMOC-2) (Smooth muscle-associated protein 2) (SMAP-2).

TNPO1_HUMAN
θ value	4.03905 (rank : 34)	NC score	0.034274 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	64	Shared Neighborhood Hits	8
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

GOGB1_HUMAN
θ value	5.27518 (rank : 35)	NC score	0.004396 (rank : 49)
Query Neighborhood Hits	42	Target Neighborhood Hits	2297	Shared Neighborhood Hits	9
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

TNPO1_MOUSE
θ value	5.27518 (rank : 36)	NC score	0.033063 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	63	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

FILA_HUMAN
θ value	6.88961 (rank : 37)	NC score	0.010958 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	685	Shared Neighborhood Hits	4
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

IMA3_MOUSE
θ value	6.88961 (rank : 38)	NC score	0.053061 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	23
SwissProt Accessions	O35344	Gene names	Kpna3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (Importin alpha Q2).

PKHA6_HUMAN
θ value	6.88961 (rank : 39)	NC score	0.006052 (rank : 47)
Query Neighborhood Hits	42	Target Neighborhood Hits	556	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

DBR1_MOUSE
θ value	8.99809 (rank : 40)	NC score	0.008837 (rank : 45)
Query Neighborhood Hits	42	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q923B1, Q8C1T9, Q8C7J7, Q99MT1	Gene names	Dbr1
Domain Architecture	No domain graphic available
Description	Lariat debranching enzyme (EC 3.1.-.-).

DUT_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.013589 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	52	Shared Neighborhood Hits	2
SwissProt Accessions	P33316, O14785, Q16708, Q16860, Q96Q81	Gene names	DUT
Domain Architecture
Description	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (EC 3.6.1.23) (dUTPase) (dUTP pyrophosphatase).

GPR98_MOUSE
θ value	8.99809 (rank : 42)	NC score	0.004446 (rank : 48)
Query Neighborhood Hits	42	Target Neighborhood Hits	206	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VHN7, Q6ZQ69, Q810D2, Q810D3, Q91ZS0, Q91ZS1	Gene names	Gpr98, Kiaa0686, Mass1, Vlgr1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1) (Very large G-protein coupled receptor 1) (Neurepin).

IMA2_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.058910 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	P52292, Q9BRU5	Gene names	KPNA2, RCH1, SRP1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1).

IMA2_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.058663 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	46	Shared Neighborhood Hits	16
SwissProt Accessions	P52293, Q64292	Gene names	Kpna2, Rch1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) (Pendulin) (Pore targeting complex 58 kDa subunit) (PTAC58) (Importin alpha P1).

IMA3_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.050177 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	53	Shared Neighborhood Hits	21
SwissProt Accessions	O00505, O00191, O43195, Q96AA7	Gene names	KPNA3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (SRP1-gamma).

IMA4_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.054856 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	59	Shared Neighborhood Hits	20
SwissProt Accessions	O00629, O00190	Gene names	KPNA4, QIP1
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Qip1 protein).

IMA4_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.054851 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	60	Shared Neighborhood Hits	19
SwissProt Accessions	O35343	Gene names	Kpna4
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Importin alpha Q1).

IMA7_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.068383 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	50	Shared Neighborhood Hits	18
SwissProt Accessions	O60684	Gene names	KPNA6, IPOA7
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6).

IMA7_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.070734 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	50	Shared Neighborhood Hits	19
SwissProt Accessions	O35345, Q9CVP9	Gene names	Kpna6, Kpna5
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6 subunit) (Importin alpha S2).

Hits sorted by NC score

PKP3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y446	Gene names	PKP3
Domain Architecture
Description	Plakophilin-3.

PKP3_MOUSE
NC score	0.997772 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QY23	Gene names	Pkp3
Domain Architecture
Description	Plakophilin-3.

PKP1_MOUSE
NC score	0.928069 (rank : 3)	θ value	9.11921e-69 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	37	Shared Neighborhood Hits	21
SwissProt Accessions	P97350	Gene names	Pkp1
Domain Architecture
Description	Plakophilin-1.

PKP1_HUMAN
NC score	0.924726 (rank : 4)	θ value	2.74572e-65 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	Q13835, O00645, Q15152	Gene names	PKP1
Domain Architecture
Description	Plakophilin-1 (Band-6 protein) (B6P).

PKP2_HUMAN
NC score	0.922607 (rank : 5)	θ value	2.25136e-59 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	40	Shared Neighborhood Hits	18
SwissProt Accessions	Q99959, Q99960	Gene names	PKP2
Domain Architecture
Description	Plakophilin-2.

ARVC_MOUSE
NC score	0.912157 (rank : 6)	θ value	3.35642e-63 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	67	Shared Neighborhood Hits	22
SwissProt Accessions	P98203, Q6PGJ6, Q8BQ36, Q8BRF2, Q8C3U7, Q924L2, Q924L3, Q924L4, Q924L5	Gene names	Arvcf
Domain Architecture	No domain graphic available
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog.

ARVC_HUMAN
NC score	0.910024 (rank : 7)	θ value	5.17823e-64 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	95	Shared Neighborhood Hits	22
SwissProt Accessions	O00192	Gene names	ARVCF
Domain Architecture
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome.

CTND1_MOUSE
NC score	0.907148 (rank : 8)	θ value	2.40537e-61 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	69	Shared Neighborhood Hits	23
SwissProt Accessions	P30999	Gene names	Ctnnd1, Catns
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

CTND1_HUMAN
NC score	0.907103 (rank : 9)	θ value	2.17557e-62 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	67	Shared Neighborhood Hits	23
SwissProt Accessions	O60716, O15088, O60713, O60714, O60715, O60935, Q6RBX8, Q9UP71, Q9UP72, Q9UP73	Gene names	CTNND1, KIAA0384
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

PKP4_MOUSE
NC score	0.901271 (rank : 10)	θ value	2.93355e-67 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	129	Shared Neighborhood Hits	24
SwissProt Accessions	Q68FH0, Q640N0, Q68G56, Q8BK47, Q8BVH1, Q9CRE3	Gene names	Pkp4, Armrp
Domain Architecture	No domain graphic available
Description	Plakophilin-4 (Armadillo-related protein).

PKP4_HUMAN
NC score	0.898959 (rank : 11)	θ value	1.50663e-63 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	107	Shared Neighborhood Hits	23
SwissProt Accessions	Q99569	Gene names	PKP4
Domain Architecture
Description	Plakophilin-4 (p0071).

CTND2_MOUSE
NC score	0.886555 (rank : 12)	θ value	2.17557e-62 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	227	Shared Neighborhood Hits	24
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

CTND2_HUMAN
NC score	0.876183 (rank : 13)	θ value	1.2325e-65 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	333	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

ARMC4_HUMAN
NC score	0.340242 (rank : 14)	θ value	0.0113563 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	88	Shared Neighborhood Hits	23
SwissProt Accessions	Q5T2S8, Q9H0C0	Gene names	ARMC4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 4.

CTNB1_MOUSE
NC score	0.263737 (rank : 15)	θ value	0.0252991 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	50	Shared Neighborhood Hits	23
SwissProt Accessions	Q02248, Q922W1, Q9D335	Gene names	Ctnnb1, Catnb
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

CTNB1_HUMAN
NC score	0.263681 (rank : 16)	θ value	0.0252991 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	23
SwissProt Accessions	P35222, Q8NEW9, Q8NI94, Q9H391	Gene names	CTNNB1, CTNNB
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

PLAK_MOUSE
NC score	0.247546 (rank : 17)	θ value	0.00175202 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	55	Shared Neighborhood Hits	21
SwissProt Accessions	Q02257, Q8CGD3	Gene names	Jup
Domain Architecture	No domain graphic available
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

PLAK_HUMAN
NC score	0.215992 (rank : 18)	θ value	0.00228821 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	53	Shared Neighborhood Hits	21
SwissProt Accessions	P14923, Q9HCX9	Gene names	JUP, DP3
Domain Architecture
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

APC_MOUSE
NC score	0.179797 (rank : 19)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	441	Shared Neighborhood Hits	24
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

APC_HUMAN
NC score	0.174699 (rank : 20)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	603	Shared Neighborhood Hits	24
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

GDS1_HUMAN
NC score	0.137208 (rank : 21)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	19
SwissProt Accessions	P52306, Q9NYM2, Q9NZA8	Gene names	RAP1GDS1
Domain Architecture
Description	Rap1 GTPase-GDP dissociation stimulator 1 (SMG P21 stimulatory GDP/GTP exchange protein) (SMG GDS protein) (Exchange factor smgGDS).

IMA7_MOUSE
NC score	0.070734 (rank : 22)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	42	Target Neighborhood Hits	50	Shared Neighborhood Hits	19
SwissProt Accessions	O35345, Q9CVP9	Gene names	Kpna6, Kpna5
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6 subunit) (Importin alpha S2).

IMA5_HUMAN
NC score	0.069655 (rank : 23)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	68	Shared Neighborhood Hits	22
SwissProt Accessions	O15131	Gene names	KPNA5
Domain Architecture
Description	Importin alpha-6 subunit (Karyopherin alpha-5 subunit).

IMA7_HUMAN
NC score	0.068383 (rank : 24)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	42	Target Neighborhood Hits	50	Shared Neighborhood Hits	18
SwissProt Accessions	O60684	Gene names	KPNA6, IPOA7
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6).

IMA2_HUMAN
NC score	0.058910 (rank : 25)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	P52292, Q9BRU5	Gene names	KPNA2, RCH1, SRP1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1).

IMA2_MOUSE
NC score	0.058663 (rank : 26)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	46	Shared Neighborhood Hits	16
SwissProt Accessions	P52293, Q64292	Gene names	Kpna2, Rch1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) (Pendulin) (Pore targeting complex 58 kDa subunit) (PTAC58) (Importin alpha P1).

IMA4_HUMAN
NC score	0.054856 (rank : 27)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	42	Target Neighborhood Hits	59	Shared Neighborhood Hits	20
SwissProt Accessions	O00629, O00190	Gene names	KPNA4, QIP1
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Qip1 protein).

IMA4_MOUSE
NC score	0.054851 (rank : 28)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	42	Target Neighborhood Hits	60	Shared Neighborhood Hits	19
SwissProt Accessions	O35343	Gene names	Kpna4
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Importin alpha Q1).

IMA3_MOUSE
NC score	0.053061 (rank : 29)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	23
SwissProt Accessions	O35344	Gene names	Kpna3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (Importin alpha Q2).

IMA3_HUMAN
NC score	0.050177 (rank : 30)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	42	Target Neighborhood Hits	53	Shared Neighborhood Hits	21
SwissProt Accessions	O00505, O00191, O43195, Q96AA7	Gene names	KPNA3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (SRP1-gamma).

TNPO2_HUMAN
NC score	0.037917 (rank : 31)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	47	Shared Neighborhood Hits	7
SwissProt Accessions	O14787, O14655	Gene names	TNPO2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

TNPO2_MOUSE
NC score	0.037866 (rank : 32)	θ value	1.06291 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	47	Shared Neighborhood Hits	7
SwissProt Accessions	Q99LG2, Q8C0U9	Gene names	Tnpo2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

TNPO1_HUMAN
NC score	0.034274 (rank : 33)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	64	Shared Neighborhood Hits	8
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

TTF1_MOUSE
NC score	0.034081 (rank : 34)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	277	Shared Neighborhood Hits	4
SwissProt Accessions	Q62187, Q9JKK5	Gene names	Ttf1
Domain Architecture	No domain graphic available
Description	Transcription termination factor 1 (TTF-1) (TTF-I) (mTFF-I) (RNA polymerase I termination factor).

TNPO1_MOUSE
NC score	0.033063 (rank : 35)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	63	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

UBE4B_HUMAN
NC score	0.020513 (rank : 36)	θ value	1.06291 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	158	Shared Neighborhood Hits	2
SwissProt Accessions	O95155, O75169, O95338, Q5SZ12, Q5SZ16, Q96QD4, Q9BYI7	Gene names	UBE4B, HDNB1, KIAA0684, UFD2
Domain Architecture
Description	Ubiquitin conjugation factor E4 B (Ubiquitin fusion degradation protein 2) (Homozygously deleted in neuroblastoma 1).

AXUD1_HUMAN
NC score	0.019193 (rank : 37)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q96S65	Gene names	AXUD1, TAIP3
Domain Architecture	No domain graphic available
Description	Axin-1 up-regulated gene 1 protein (TGF-beta-induced apoptosis protein 3) (TAIP-3) (URAX1 protein).

NFKB1_HUMAN
NC score	0.017610 (rank : 38)	θ value	0.279714 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	306	Shared Neighborhood Hits	3
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

EFNB3_HUMAN
NC score	0.016705 (rank : 39)	θ value	1.38821 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	48	Shared Neighborhood Hits	2
SwissProt Accessions	Q15768, O00680, Q8TBH7, Q92875	Gene names	EFNB3, EPLG8, LERK8
Domain Architecture
Description	Ephrin-B3 precursor (EPH-related receptor tyrosine kinase ligand 8) (LERK-8) (EPH-related receptor transmembrane ligand ELK-L3).

SYP2L_MOUSE
NC score	0.015835 (rank : 40)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	289	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

SMOC2_HUMAN
NC score	0.015807 (rank : 41)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H3U7, Q5TAT7, Q5TAT8, Q86VV9, Q96SF3, Q9H1L3, Q9H1L4, Q9H3U0, Q9H4F7, Q9HCV2	Gene names	SMOC2, SMAP2
Domain Architecture
Description	SPARC-related modular calcium-binding protein 2 precursor (Secreted modular calcium-binding protein 2) (SMOC-2) (Smooth muscle-associated protein 2) (SMAP-2).

DUT_HUMAN
NC score	0.013589 (rank : 42)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	52	Shared Neighborhood Hits	2
SwissProt Accessions	P33316, O14785, Q16708, Q16860, Q96Q81	Gene names	DUT
Domain Architecture
Description	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (EC 3.6.1.23) (dUTPase) (dUTP pyrophosphatase).

FILA_HUMAN
NC score	0.010958 (rank : 43)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	685	Shared Neighborhood Hits	4
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

SYNE1_HUMAN
NC score	0.010917 (rank : 44)	θ value	0.62314 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	1484	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

DBR1_MOUSE
NC score	0.008837 (rank : 45)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q923B1, Q8C1T9, Q8C7J7, Q99MT1	Gene names	Dbr1
Domain Architecture	No domain graphic available
Description	Lariat debranching enzyme (EC 3.1.-.-).

KCNH2_HUMAN
NC score	0.008671 (rank : 46)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	158	Shared Neighborhood Hits	2
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

PKHA6_HUMAN
NC score	0.006052 (rank : 47)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	556	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

GPR98_MOUSE
NC score	0.004446 (rank : 48)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	206	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VHN7, Q6ZQ69, Q810D2, Q810D3, Q91ZS0, Q91ZS1	Gene names	Gpr98, Kiaa0686, Mass1, Vlgr1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1) (Very large G-protein coupled receptor 1) (Neurepin).

GOGB1_HUMAN
NC score	0.004396 (rank : 49)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	2297	Shared Neighborhood Hits	9
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).