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Network neighborhood for query Sequence : PI4KA_HUMAN

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PI4KA_HUMAN
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PI4KA_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	53	Target Neighborhood Hits	53	Shared Neighborhood Hits	53
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

PI4KB_HUMAN
θ value	3.60269e-49 (rank : 2)	NC score	0.856250 (rank : 3)
Query Neighborhood Hits	53	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
θ value	6.14528e-49 (rank : 3)	NC score	0.857814 (rank : 2)
Query Neighborhood Hits	53	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PK3CA_HUMAN
θ value	1.08726e-37 (rank : 4)	NC score	0.830097 (rank : 4)
Query Neighborhood Hits	53	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
θ value	5.39604e-37 (rank : 5)	NC score	0.829407 (rank : 5)
Query Neighborhood Hits	53	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CG_MOUSE
θ value	2.77131e-33 (rank : 6)	NC score	0.829233 (rank : 7)
Query Neighborhood Hits	53	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

P3C2A_MOUSE
θ value	3.06405e-32 (rank : 7)	NC score	0.732404 (rank : 16)
Query Neighborhood Hits	53	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

PK3CG_HUMAN
θ value	3.06405e-32 (rank : 8)	NC score	0.829320 (rank : 6)
Query Neighborhood Hits	53	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

P3C2G_HUMAN
θ value	7.54701e-31 (rank : 9)	NC score	0.809030 (rank : 10)
Query Neighborhood Hits	53	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_MOUSE
θ value	1.6813e-30 (rank : 10)	NC score	0.806687 (rank : 11)
Query Neighborhood Hits	53	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2B_HUMAN
θ value	2.86786e-30 (rank : 11)	NC score	0.709246 (rank : 18)
Query Neighborhood Hits	53	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

P3C2A_HUMAN
θ value	1.4233e-29 (rank : 12)	NC score	0.727670 (rank : 17)
Query Neighborhood Hits	53	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

PK3C3_MOUSE
θ value	3.87602e-27 (rank : 13)	NC score	0.813736 (rank : 8)
Query Neighborhood Hits	53	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3CB_MOUSE
θ value	3.28125e-26 (rank : 14)	NC score	0.805463 (rank : 12)
Query Neighborhood Hits	53	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3C3_HUMAN
θ value	5.59698e-26 (rank : 15)	NC score	0.812347 (rank : 9)
Query Neighborhood Hits	53	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3CB_HUMAN
θ value	1.62847e-25 (rank : 16)	NC score	0.804736 (rank : 13)
Query Neighborhood Hits	53	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CD_HUMAN
θ value	1.37858e-24 (rank : 17)	NC score	0.804403 (rank : 14)
Query Neighborhood Hits	53	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
θ value	6.84181e-24 (rank : 18)	NC score	0.803363 (rank : 15)
Query Neighborhood Hits	53	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

FRAP_HUMAN
θ value	2.44474e-05 (rank : 19)	NC score	0.391443 (rank : 20)
Query Neighborhood Hits	53	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_MOUSE
θ value	2.44474e-05 (rank : 20)	NC score	0.391968 (rank : 19)
Query Neighborhood Hits	53	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

ATR_HUMAN
θ value	0.000461057 (rank : 21)	NC score	0.333679 (rank : 21)
Query Neighborhood Hits	53	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
θ value	0.000461057 (rank : 22)	NC score	0.333225 (rank : 22)
Query Neighborhood Hits	53	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATM_HUMAN
θ value	0.0252991 (rank : 23)	NC score	0.312126 (rank : 24)
Query Neighborhood Hits	53	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

SMG1_HUMAN
θ value	0.0252991 (rank : 24)	NC score	0.260883 (rank : 28)
Query Neighborhood Hits	53	Target Neighborhood Hits	231	Shared Neighborhood Hits	28
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

SMG1_MOUSE
θ value	0.0252991 (rank : 25)	NC score	0.262995 (rank : 27)
Query Neighborhood Hits	53	Target Neighborhood Hits	212	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

ATM_MOUSE
θ value	0.0431538 (rank : 26)	NC score	0.304689 (rank : 26)
Query Neighborhood Hits	53	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

CEP35_HUMAN
θ value	0.365318 (rank : 27)	NC score	0.025427 (rank : 46)
Query Neighborhood Hits	53	Target Neighborhood Hits	811	Shared Neighborhood Hits	7
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

PRKDC_MOUSE
θ value	0.47712 (rank : 28)	NC score	0.319553 (rank : 23)
Query Neighborhood Hits	53	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
θ value	1.06291 (rank : 29)	NC score	0.307833 (rank : 25)
Query Neighborhood Hits	53	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

AMPE_MOUSE
θ value	1.38821 (rank : 30)	NC score	0.013402 (rank : 54)
Query Neighborhood Hits	53	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	P16406	Gene names	Enpep
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (BP-1/6C3 antigen).

AP2A2_HUMAN
θ value	2.36792 (rank : 31)	NC score	0.018232 (rank : 51)
Query Neighborhood Hits	53	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP2A2_MOUSE
θ value	2.36792 (rank : 32)	NC score	0.018199 (rank : 52)
Query Neighborhood Hits	53	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

CJ093_HUMAN
θ value	2.36792 (rank : 33)	NC score	0.035220 (rank : 44)
Query Neighborhood Hits	53	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SR76, Q86ST2, Q8N777	Gene names	C10orf93
Domain Architecture	No domain graphic available
Description	Protein C10orf93.

MAPE_HUMAN
θ value	2.36792 (rank : 34)	NC score	0.012595 (rank : 56)
Query Neighborhood Hits	53	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	P78395, O43481, Q8IXN8	Gene names	PRAME, MAPE
Domain Architecture	No domain graphic available
Description	Melanoma antigen preferentially expressed in tumors (Preferentially expressed antigen of melanoma) (OPA-interacting protein 4) (OIP4).

INT1_MOUSE
θ value	3.0926 (rank : 35)	NC score	0.026496 (rank : 45)
Query Neighborhood Hits	53	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P4S8, Q80UQ7, Q91Z01, Q9CTF7	Gene names	Ints1
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

ABCA7_MOUSE
θ value	4.03905 (rank : 36)	NC score	0.005675 (rank : 66)
Query Neighborhood Hits	53	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	Q91V24, Q9JL36	Gene names	Abca7
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 7.

CCD62_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.006717 (rank : 64)
Query Neighborhood Hits	53	Target Neighborhood Hits	631	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P9F0, Q6ZVF2, Q86VJ0, Q9BYZ5	Gene names	CCDC62
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 60 (Aaa-protein) (Protein TSP- NY).

DYH5_HUMAN
θ value	4.03905 (rank : 38)	NC score	0.009958 (rank : 60)
Query Neighborhood Hits	53	Target Neighborhood Hits	323	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TE73, Q92860, Q96L74, Q9H5S7, Q9HCG9	Gene names	DNAH5, DNAHC5, KIAA1603
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (HL1).

INT1_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.025255 (rank : 47)
Query Neighborhood Hits	53	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N201, Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8	Gene names	INTS1, KIAA1440
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

SPESP_HUMAN
θ value	4.03905 (rank : 40)	NC score	0.024301 (rank : 48)
Query Neighborhood Hits	53	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UW49, Q8NG22, Q8WVH8	Gene names	SPESP1
Domain Architecture	No domain graphic available
Description	Sperm equatorial segment protein 1 precursor (SP-ESP) (Equatorial segment protein) (ESP) (Glycosylated 38 kDa sperm protein C-7/8).

HC127_HUMAN
θ value	5.27518 (rank : 41)	NC score	0.018841 (rank : 49)
Query Neighborhood Hits	53	Target Neighborhood Hits	292	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NQZ6, Q5JTF9, Q9H9C3, Q9H9H7, Q9ULQ4	Gene names	HCA127, KIAA1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127.

HC127_MOUSE
θ value	5.27518 (rank : 42)	NC score	0.018841 (rank : 50)
Query Neighborhood Hits	53	Target Neighborhood Hits	292	Shared Neighborhood Hits	5
SwissProt Accessions	Q68FG0, Q6ZPW6	Gene names	Hca127, Kiaa1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127 homolog.

K0562_MOUSE
θ value	5.27518 (rank : 43)	NC score	0.014965 (rank : 53)
Query Neighborhood Hits	53	Target Neighborhood Hits	86	Shared Neighborhood Hits	2
SwissProt Accessions	Q80V31, Q6ZQ95	Gene names	Kiaa0562
Domain Architecture	No domain graphic available
Description	Protein KIAA0562.

NBEA_HUMAN
θ value	5.27518 (rank : 44)	NC score	0.012416 (rank : 57)
Query Neighborhood Hits	53	Target Neighborhood Hits	186	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NFP9, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1	Gene names	NBEA, BCL8B, KIAA1544, LYST2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B).

NBEA_MOUSE
θ value	5.27518 (rank : 45)	NC score	0.012298 (rank : 58)
Query Neighborhood Hits	53	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

UBP29_MOUSE
θ value	5.27518 (rank : 46)	NC score	0.009942 (rank : 61)
Query Neighborhood Hits	53	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ES63	Gene names	Usp29
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) (Deubiquitinating enzyme 29).

CS007_MOUSE
θ value	6.88961 (rank : 47)	NC score	0.007775 (rank : 63)
Query Neighborhood Hits	53	Target Neighborhood Hits	464	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

PSB10_MOUSE
θ value	6.88961 (rank : 48)	NC score	0.009126 (rank : 62)
Query Neighborhood Hits	53	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	O35955, O08687, Q99KC5	Gene names	Psmb10, Lmp10, Mecl1
Domain Architecture
Description	Proteasome subunit beta type 10 precursor (EC 3.4.25.1) (Proteasome MECl-1) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1).

RIOK2_MOUSE
θ value	6.88961 (rank : 49)	NC score	0.012933 (rank : 55)
Query Neighborhood Hits	53	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQS5, Q91XF3	Gene names	Riok2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).

EXT2_MOUSE
θ value	8.99809 (rank : 50)	NC score	0.006656 (rank : 65)
Query Neighborhood Hits	53	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P70428, P70395, Q923D6	Gene names	Ext2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2 homolog).

GA2L2_MOUSE
θ value	8.99809 (rank : 51)	NC score	0.005657 (rank : 67)
Query Neighborhood Hits	53	Target Neighborhood Hits	395	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

NT5D1_HUMAN
θ value	8.99809 (rank : 52)	NC score	0.011033 (rank : 59)
Query Neighborhood Hits	53	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TFE4, Q6XYD5	Gene names	NT5DC1
Domain Architecture	No domain graphic available
Description	5'-nucleotidase domain-containing protein 1.

TLR4_HUMAN
θ value	8.99809 (rank : 53)	NC score	0.002116 (rank : 68)
Query Neighborhood Hits	53	Target Neighborhood Hits	298	Shared Neighborhood Hits	2
SwissProt Accessions	O00206, Q9UK78, Q9UM57	Gene names	TLR4
Domain Architecture
Description	Toll-like receptor 4 precursor (hToll) (CD284 antigen).

FA62A_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.065188 (rank : 32)
Query Neighborhood Hits	53	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.073038 (rank : 31)
Query Neighborhood Hits	53	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RIMS1_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.061669 (rank : 34)
Query Neighborhood Hits	53	Target Neighborhood Hits	437	Shared Neighborhood Hits	5
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.052520 (rank : 39)
Query Neighborhood Hits	53	Target Neighborhood Hits	342	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.052537 (rank : 38)
Query Neighborhood Hits	53	Target Neighborhood Hits	376	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS4_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.074858 (rank : 29)
Query Neighborhood Hits	53	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.074856 (rank : 30)
Query Neighborhood Hits	53	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

SYTL1_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.055444 (rank : 35)
Query Neighborhood Hits	53	Target Neighborhood Hits	227	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL1_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.051462 (rank : 40)
Query Neighborhood Hits	53	Target Neighborhood Hits	314	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL2_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.050988 (rank : 41)
Query Neighborhood Hits	53	Target Neighborhood Hits	248	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL3_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.065156 (rank : 33)
Query Neighborhood Hits	53	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYTL4_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.050246 (rank : 43)
Query Neighborhood Hits	53	Target Neighborhood Hits	138	Shared Neighborhood Hits	5
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL5_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.054149 (rank : 36)
Query Neighborhood Hits	53	Target Neighborhood Hits	237	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.053544 (rank : 37)
Query Neighborhood Hits	53	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

TRRAP_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.050510 (rank : 42)
Query Neighborhood Hits	53	Target Neighborhood Hits	117	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

Hits sorted by NC score

PI4KA_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	53	Target Neighborhood Hits	53	Shared Neighborhood Hits	53
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

PI4KB_MOUSE
NC score	0.857814 (rank : 2)	θ value	6.14528e-49 (rank : 3)
Query Neighborhood Hits	53	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PI4KB_HUMAN
NC score	0.856250 (rank : 3)	θ value	3.60269e-49 (rank : 2)
Query Neighborhood Hits	53	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PK3CA_HUMAN
NC score	0.830097 (rank : 4)	θ value	1.08726e-37 (rank : 4)
Query Neighborhood Hits	53	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
NC score	0.829407 (rank : 5)	θ value	5.39604e-37 (rank : 5)
Query Neighborhood Hits	53	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CG_HUMAN
NC score	0.829320 (rank : 6)	θ value	3.06405e-32 (rank : 8)
Query Neighborhood Hits	53	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
NC score	0.829233 (rank : 7)	θ value	2.77131e-33 (rank : 6)
Query Neighborhood Hits	53	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3C3_MOUSE
NC score	0.813736 (rank : 8)	θ value	3.87602e-27 (rank : 13)
Query Neighborhood Hits	53	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3C3_HUMAN
NC score	0.812347 (rank : 9)	θ value	5.59698e-26 (rank : 15)
Query Neighborhood Hits	53	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

P3C2G_HUMAN
NC score	0.809030 (rank : 10)	θ value	7.54701e-31 (rank : 9)
Query Neighborhood Hits	53	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_MOUSE
NC score	0.806687 (rank : 11)	θ value	1.6813e-30 (rank : 10)
Query Neighborhood Hits	53	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PK3CB_MOUSE
NC score	0.805463 (rank : 12)	θ value	3.28125e-26 (rank : 14)
Query Neighborhood Hits	53	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_HUMAN
NC score	0.804736 (rank : 13)	θ value	1.62847e-25 (rank : 16)
Query Neighborhood Hits	53	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CD_HUMAN
NC score	0.804403 (rank : 14)	θ value	1.37858e-24 (rank : 17)
Query Neighborhood Hits	53	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
NC score	0.803363 (rank : 15)	θ value	6.84181e-24 (rank : 18)
Query Neighborhood Hits	53	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

P3C2A_MOUSE
NC score	0.732404 (rank : 16)	θ value	3.06405e-32 (rank : 7)
Query Neighborhood Hits	53	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.727670 (rank : 17)	θ value	1.4233e-29 (rank : 12)
Query Neighborhood Hits	53	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2B_HUMAN
NC score	0.709246 (rank : 18)	θ value	2.86786e-30 (rank : 11)
Query Neighborhood Hits	53	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

FRAP_MOUSE
NC score	0.391968 (rank : 19)	θ value	2.44474e-05 (rank : 20)
Query Neighborhood Hits	53	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
NC score	0.391443 (rank : 20)	θ value	2.44474e-05 (rank : 19)
Query Neighborhood Hits	53	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

ATR_HUMAN
NC score	0.333679 (rank : 21)	θ value	0.000461057 (rank : 21)
Query Neighborhood Hits	53	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
NC score	0.333225 (rank : 22)	θ value	0.000461057 (rank : 22)
Query Neighborhood Hits	53	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

PRKDC_MOUSE
NC score	0.319553 (rank : 23)	θ value	0.47712 (rank : 28)
Query Neighborhood Hits	53	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

ATM_HUMAN
NC score	0.312126 (rank : 24)	θ value	0.0252991 (rank : 23)
Query Neighborhood Hits	53	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

PRKDC_HUMAN
NC score	0.307833 (rank : 25)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	53	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

ATM_MOUSE
NC score	0.304689 (rank : 26)	θ value	0.0431538 (rank : 26)
Query Neighborhood Hits	53	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

SMG1_MOUSE
NC score	0.262995 (rank : 27)	θ value	0.0252991 (rank : 25)
Query Neighborhood Hits	53	Target Neighborhood Hits	212	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
NC score	0.260883 (rank : 28)	θ value	0.0252991 (rank : 24)
Query Neighborhood Hits	53	Target Neighborhood Hits	231	Shared Neighborhood Hits	28
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

RIMS4_HUMAN
NC score	0.074858 (rank : 29)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	53	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
NC score	0.074856 (rank : 30)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	53	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

FA62A_MOUSE
NC score	0.073038 (rank : 31)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	53	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_HUMAN
NC score	0.065188 (rank : 32)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	53	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYTL3_MOUSE
NC score	0.065156 (rank : 33)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	53	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

RIMS1_HUMAN
NC score	0.061669 (rank : 34)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	53	Target Neighborhood Hits	437	Shared Neighborhood Hits	5
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

SYTL1_HUMAN
NC score	0.055444 (rank : 35)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	53	Target Neighborhood Hits	227	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL5_HUMAN
NC score	0.054149 (rank : 36)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	53	Target Neighborhood Hits	237	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
NC score	0.053544 (rank : 37)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	53	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

RIMS2_MOUSE
NC score	0.052537 (rank : 38)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	53	Target Neighborhood Hits	376	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS2_HUMAN
NC score	0.052520 (rank : 39)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	53	Target Neighborhood Hits	342	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

SYTL1_MOUSE
NC score	0.051462 (rank : 40)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	53	Target Neighborhood Hits	314	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL2_HUMAN
NC score	0.050988 (rank : 41)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	53	Target Neighborhood Hits	248	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

TRRAP_HUMAN
NC score	0.050510 (rank : 42)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	53	Target Neighborhood Hits	117	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

SYTL4_HUMAN
NC score	0.050246 (rank : 43)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	53	Target Neighborhood Hits	138	Shared Neighborhood Hits	5
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

CJ093_HUMAN
NC score	0.035220 (rank : 44)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	53	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SR76, Q86ST2, Q8N777	Gene names	C10orf93
Domain Architecture	No domain graphic available
Description	Protein C10orf93.

INT1_MOUSE
NC score	0.026496 (rank : 45)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	53	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P4S8, Q80UQ7, Q91Z01, Q9CTF7	Gene names	Ints1
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

CEP35_HUMAN
NC score	0.025427 (rank : 46)	θ value	0.365318 (rank : 27)
Query Neighborhood Hits	53	Target Neighborhood Hits	811	Shared Neighborhood Hits	7
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

INT1_HUMAN
NC score	0.025255 (rank : 47)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	53	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N201, Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8	Gene names	INTS1, KIAA1440
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

SPESP_HUMAN
NC score	0.024301 (rank : 48)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	53	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UW49, Q8NG22, Q8WVH8	Gene names	SPESP1
Domain Architecture	No domain graphic available
Description	Sperm equatorial segment protein 1 precursor (SP-ESP) (Equatorial segment protein) (ESP) (Glycosylated 38 kDa sperm protein C-7/8).

HC127_HUMAN
NC score	0.018841 (rank : 49)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	53	Target Neighborhood Hits	292	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NQZ6, Q5JTF9, Q9H9C3, Q9H9H7, Q9ULQ4	Gene names	HCA127, KIAA1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127.

HC127_MOUSE
NC score	0.018841 (rank : 50)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	53	Target Neighborhood Hits	292	Shared Neighborhood Hits	5
SwissProt Accessions	Q68FG0, Q6ZPW6	Gene names	Hca127, Kiaa1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127 homolog.

AP2A2_HUMAN
NC score	0.018232 (rank : 51)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	53	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP2A2_MOUSE
NC score	0.018199 (rank : 52)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	53	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

K0562_MOUSE
NC score	0.014965 (rank : 53)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	53	Target Neighborhood Hits	86	Shared Neighborhood Hits	2
SwissProt Accessions	Q80V31, Q6ZQ95	Gene names	Kiaa0562
Domain Architecture	No domain graphic available
Description	Protein KIAA0562.

AMPE_MOUSE
NC score	0.013402 (rank : 54)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	53	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	P16406	Gene names	Enpep
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (BP-1/6C3 antigen).

RIOK2_MOUSE
NC score	0.012933 (rank : 55)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	53	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQS5, Q91XF3	Gene names	Riok2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).

MAPE_HUMAN
NC score	0.012595 (rank : 56)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	53	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	P78395, O43481, Q8IXN8	Gene names	PRAME, MAPE
Domain Architecture	No domain graphic available
Description	Melanoma antigen preferentially expressed in tumors (Preferentially expressed antigen of melanoma) (OPA-interacting protein 4) (OIP4).

NBEA_HUMAN
NC score	0.012416 (rank : 57)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	53	Target Neighborhood Hits	186	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NFP9, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1	Gene names	NBEA, BCL8B, KIAA1544, LYST2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B).

NBEA_MOUSE
NC score	0.012298 (rank : 58)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	53	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

NT5D1_HUMAN
NC score	0.011033 (rank : 59)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	53	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TFE4, Q6XYD5	Gene names	NT5DC1
Domain Architecture	No domain graphic available
Description	5'-nucleotidase domain-containing protein 1.

DYH5_HUMAN
NC score	0.009958 (rank : 60)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	53	Target Neighborhood Hits	323	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TE73, Q92860, Q96L74, Q9H5S7, Q9HCG9	Gene names	DNAH5, DNAHC5, KIAA1603
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (HL1).

UBP29_MOUSE
NC score	0.009942 (rank : 61)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	53	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ES63	Gene names	Usp29
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) (Deubiquitinating enzyme 29).

PSB10_MOUSE
NC score	0.009126 (rank : 62)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	53	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	O35955, O08687, Q99KC5	Gene names	Psmb10, Lmp10, Mecl1
Domain Architecture
Description	Proteasome subunit beta type 10 precursor (EC 3.4.25.1) (Proteasome MECl-1) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1).

CS007_MOUSE
NC score	0.007775 (rank : 63)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	53	Target Neighborhood Hits	464	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

CCD62_HUMAN
NC score	0.006717 (rank : 64)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	53	Target Neighborhood Hits	631	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P9F0, Q6ZVF2, Q86VJ0, Q9BYZ5	Gene names	CCDC62
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 60 (Aaa-protein) (Protein TSP- NY).

EXT2_MOUSE
NC score	0.006656 (rank : 65)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	53	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P70428, P70395, Q923D6	Gene names	Ext2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2 homolog).

ABCA7_MOUSE
NC score	0.005675 (rank : 66)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	53	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	Q91V24, Q9JL36	Gene names	Abca7
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 7.

GA2L2_MOUSE
NC score	0.005657 (rank : 67)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	53	Target Neighborhood Hits	395	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

TLR4_HUMAN
NC score	0.002116 (rank : 68)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	53	Target Neighborhood Hits	298	Shared Neighborhood Hits	2
SwissProt Accessions	O00206, Q9UK78, Q9UM57	Gene names	TLR4
Domain Architecture
Description	Toll-like receptor 4 precursor (hToll) (CD284 antigen).