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Network neighborhood for query Sequence : SPESP_HUMAN

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SPESP_HUMAN
SwissProt Accessions	Q6UW49, Q8NG22, Q8WVH8	Gene names	SPESP1
Domain Architecture	No domain graphic available
Description	Sperm equatorial segment protein 1 precursor (SP-ESP) (Equatorial segment protein) (ESP) (Glycosylated 38 kDa sperm protein C-7/8).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SPESP_HUMAN
θ value	6.35588e-163 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	Q6UW49, Q8NG22, Q8WVH8	Gene names	SPESP1
Domain Architecture	No domain graphic available
Description	Sperm equatorial segment protein 1 precursor (SP-ESP) (Equatorial segment protein) (ESP) (Glycosylated 38 kDa sperm protein C-7/8).

SPESP_MOUSE
θ value	7.24236e-58 (rank : 2)	NC score	0.910272 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D5A0, Q9D5X8	Gene names	Spesp1
Domain Architecture	No domain graphic available
Description	Sperm equatorial segment protein 1 precursor.

CCNB3_HUMAN
θ value	0.47712 (rank : 3)	NC score	0.042844 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	368	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

SYNE2_HUMAN
θ value	0.47712 (rank : 4)	NC score	0.024231 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	1323	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

MIME_MOUSE
θ value	1.06291 (rank : 5)	NC score	0.024236 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	234	Shared Neighborhood Hits	2
SwissProt Accessions	Q62000	Gene names	Ogn, Og
Domain Architecture
Description	Mimecan precursor (Osteoglycin).

PCLO_MOUSE
θ value	1.38821 (rank : 6)	NC score	0.029018 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	2275	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

LIN1_HUMAN
θ value	1.81305 (rank : 7)	NC score	0.040325 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	187	Shared Neighborhood Hits	3
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

WWP1_HUMAN
θ value	2.36792 (rank : 8)	NC score	0.015713 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	262	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

PCLO_HUMAN
θ value	3.0926 (rank : 9)	NC score	0.029692 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	2046	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

TR2_HUMAN
θ value	3.0926 (rank : 10)	NC score	0.012867 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	P13056	Gene names	NR2C1, TR2
Domain Architecture
Description	Orphan nuclear receptor TR2 (Testicular receptor 2).

PI4KA_HUMAN
θ value	4.03905 (rank : 11)	NC score	0.024301 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

CCP2_HUMAN
θ value	5.27518 (rank : 12)	NC score	0.022138 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q14206	Gene names	DSCR1L1, ZAKI4
Domain Architecture
Description	Calcipressin-2 (Thyroid hormone-responsive protein ZAKI-4) (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin- interacting protein 2) (MCIP2).

EMSY_MOUSE
θ value	5.27518 (rank : 13)	NC score	0.025221 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	294	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

NCOA7_MOUSE
θ value	5.27518 (rank : 14)	NC score	0.022496 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	114	Shared Neighborhood Hits	2
SwissProt Accessions	Q6DFV7, Q3TAR1, Q3UNB3, Q66K05, Q6ZQM4, Q8BJ15, Q8BJ39	Gene names	Ncoa7
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 7.

NRBP_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.016089 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	448	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

OGFR_MOUSE
θ value	5.27518 (rank : 16)	NC score	0.018090 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	584	Shared Neighborhood Hits	5
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

UBIP1_MOUSE
θ value	5.27518 (rank : 17)	NC score	0.030839 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	90	Shared Neighborhood Hits	4
SwissProt Accessions	Q811S7, Q3UPR3, Q3US11, Q60786, Q8C514	Gene names	Ubp1, Cp2b, Nf2d9
Domain Architecture	No domain graphic available
Description	Upstream-binding protein 1 (Nuclear factor 2d9) (NF2d9).

ZEP1_MOUSE
θ value	5.27518 (rank : 18)	NC score	0.011489 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	1063	Shared Neighborhood Hits	5
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

GIDRP_MOUSE
θ value	6.88961 (rank : 19)	NC score	0.023461 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	96	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BJM3, Q3UGJ8, Q5U5U8	Gene names	Gidrp88, D19Ertd386e
Domain Architecture	No domain graphic available
Description	Growth inhibition and differentiation-related protein 88 homolog.

TF2L1_HUMAN
θ value	6.88961 (rank : 20)	NC score	0.028717 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZI6, Q4ZG43	Gene names	TFCP2L1, CRTR1, LBP9
Domain Architecture	No domain graphic available
Description	Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1) (Transcription factor LBP-9).

UBIP1_HUMAN
θ value	6.88961 (rank : 21)	NC score	0.029672 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZI7, Q68CT0, Q86Y57, Q9H8V0, Q9UD76, Q9UD78	Gene names	UBP1, LBP1
Domain Architecture	No domain graphic available
Description	Upstream-binding protein 1 (LBP-1).

ZEP2_HUMAN
θ value	6.88961 (rank : 22)	NC score	0.010633 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	937	Shared Neighborhood Hits	5
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

NRBP_MOUSE
θ value	8.99809 (rank : 23)	NC score	0.014266 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	442	Shared Neighborhood Hits	3
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

ST32A_HUMAN
θ value	8.99809 (rank : 24)	NC score	0.000903 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	834	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

Hits sorted by NC score

SPESP_HUMAN
NC score	0.999962 (rank : 1)	θ value	6.35588e-163 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	Q6UW49, Q8NG22, Q8WVH8	Gene names	SPESP1
Domain Architecture	No domain graphic available
Description	Sperm equatorial segment protein 1 precursor (SP-ESP) (Equatorial segment protein) (ESP) (Glycosylated 38 kDa sperm protein C-7/8).

SPESP_MOUSE
NC score	0.910272 (rank : 2)	θ value	7.24236e-58 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D5A0, Q9D5X8	Gene names	Spesp1
Domain Architecture	No domain graphic available
Description	Sperm equatorial segment protein 1 precursor.

CCNB3_HUMAN
NC score	0.042844 (rank : 3)	θ value	0.47712 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	368	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

LIN1_HUMAN
NC score	0.040325 (rank : 4)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	187	Shared Neighborhood Hits	3
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

UBIP1_MOUSE
NC score	0.030839 (rank : 5)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	90	Shared Neighborhood Hits	4
SwissProt Accessions	Q811S7, Q3UPR3, Q3US11, Q60786, Q8C514	Gene names	Ubp1, Cp2b, Nf2d9
Domain Architecture	No domain graphic available
Description	Upstream-binding protein 1 (Nuclear factor 2d9) (NF2d9).

PCLO_HUMAN
NC score	0.029692 (rank : 6)	θ value	3.0926 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	2046	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

UBIP1_HUMAN
NC score	0.029672 (rank : 7)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZI7, Q68CT0, Q86Y57, Q9H8V0, Q9UD76, Q9UD78	Gene names	UBP1, LBP1
Domain Architecture	No domain graphic available
Description	Upstream-binding protein 1 (LBP-1).

PCLO_MOUSE
NC score	0.029018 (rank : 8)	θ value	1.38821 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	2275	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

TF2L1_HUMAN
NC score	0.028717 (rank : 9)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZI6, Q4ZG43	Gene names	TFCP2L1, CRTR1, LBP9
Domain Architecture	No domain graphic available
Description	Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1) (Transcription factor LBP-9).

EMSY_MOUSE
NC score	0.025221 (rank : 10)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	294	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

PI4KA_HUMAN
NC score	0.024301 (rank : 11)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

MIME_MOUSE
NC score	0.024236 (rank : 12)	θ value	1.06291 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	234	Shared Neighborhood Hits	2
SwissProt Accessions	Q62000	Gene names	Ogn, Og
Domain Architecture
Description	Mimecan precursor (Osteoglycin).

SYNE2_HUMAN
NC score	0.024231 (rank : 13)	θ value	0.47712 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	1323	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

GIDRP_MOUSE
NC score	0.023461 (rank : 14)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	96	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BJM3, Q3UGJ8, Q5U5U8	Gene names	Gidrp88, D19Ertd386e
Domain Architecture	No domain graphic available
Description	Growth inhibition and differentiation-related protein 88 homolog.

NCOA7_MOUSE
NC score	0.022496 (rank : 15)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	114	Shared Neighborhood Hits	2
SwissProt Accessions	Q6DFV7, Q3TAR1, Q3UNB3, Q66K05, Q6ZQM4, Q8BJ15, Q8BJ39	Gene names	Ncoa7
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 7.

CCP2_HUMAN
NC score	0.022138 (rank : 16)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q14206	Gene names	DSCR1L1, ZAKI4
Domain Architecture
Description	Calcipressin-2 (Thyroid hormone-responsive protein ZAKI-4) (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin- interacting protein 2) (MCIP2).

OGFR_MOUSE
NC score	0.018090 (rank : 17)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	584	Shared Neighborhood Hits	5
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

NRBP_HUMAN
NC score	0.016089 (rank : 18)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	448	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

WWP1_HUMAN
NC score	0.015713 (rank : 19)	θ value	2.36792 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	262	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

NRBP_MOUSE
NC score	0.014266 (rank : 20)	θ value	8.99809 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	442	Shared Neighborhood Hits	3
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

TR2_HUMAN
NC score	0.012867 (rank : 21)	θ value	3.0926 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	P13056	Gene names	NR2C1, TR2
Domain Architecture
Description	Orphan nuclear receptor TR2 (Testicular receptor 2).

ZEP1_MOUSE
NC score	0.011489 (rank : 22)	θ value	5.27518 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	1063	Shared Neighborhood Hits	5
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

ZEP2_HUMAN
NC score	0.010633 (rank : 23)	θ value	6.88961 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	937	Shared Neighborhood Hits	5
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

ST32A_HUMAN
NC score	0.000903 (rank : 24)	θ value	8.99809 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	834	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).