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Network neighborhood for query Sequence : RIOK2_MOUSE

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RIOK2_MOUSE
SwissProt Accessions	Q9CQS5, Q91XF3	Gene names	Riok2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RIOK2_HUMAN
θ value	0 (rank : 1)	NC score	0.959589 (rank : 2)
Query Neighborhood Hits	82	Target Neighborhood Hits	125	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BVS4, Q9NUT0	Gene names	RIOK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).

RIOK2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	82	Target Neighborhood Hits	82	Shared Neighborhood Hits	82
SwissProt Accessions	Q9CQS5, Q91XF3	Gene names	Riok2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).

RIOK1_HUMAN
θ value	3.29651e-10 (rank : 3)	NC score	0.420852 (rank : 3)
Query Neighborhood Hits	82	Target Neighborhood Hits	86	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BRS2, Q8NDC8, Q96NV9	Gene names	RIOK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (RIO kinase 1).

RIOK3_MOUSE
θ value	6.43352e-06 (rank : 4)	NC score	0.346306 (rank : 4)
Query Neighborhood Hits	82	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBU3, Q8CIC1	Gene names	Riok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3).

RIOK3_HUMAN
θ value	2.44474e-05 (rank : 5)	NC score	0.337475 (rank : 5)
Query Neighborhood Hits	82	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	O14730, Q8IXN9	Gene names	RIOK3, SUDD
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog).

NRK_HUMAN
θ value	0.0113563 (rank : 6)	NC score	0.084005 (rank : 6)
Query Neighborhood Hits	82	Target Neighborhood Hits	931	Shared Neighborhood Hits	64
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

NRK_MOUSE
θ value	0.0148317 (rank : 7)	NC score	0.082169 (rank : 7)
Query Neighborhood Hits	82	Target Neighborhood Hits	899	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

TNIK_HUMAN
θ value	0.0961366 (rank : 8)	NC score	0.061458 (rank : 101)
Query Neighborhood Hits	82	Target Neighborhood Hits	1570	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TYDP1_MOUSE
θ value	0.0961366 (rank : 9)	NC score	0.068238 (rank : 41)
Query Neighborhood Hits	82	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BJ37, Q8VE39	Gene names	Tdp1
Domain Architecture
Description	Tyrosyl-DNA phosphodiesterase 1 (EC 3.1.4.-) (Tyr-DNA phosphodiesterase 1).

KPCB_HUMAN
θ value	0.21417 (rank : 10)	NC score	0.080168 (rank : 8)
Query Neighborhood Hits	82	Target Neighborhood Hits	1121	Shared Neighborhood Hits	62
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	0.21417 (rank : 11)	NC score	0.080156 (rank : 9)
Query Neighborhood Hits	82	Target Neighborhood Hits	1117	Shared Neighborhood Hits	62
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCA_HUMAN
θ value	0.279714 (rank : 12)	NC score	0.078723 (rank : 10)
Query Neighborhood Hits	82	Target Neighborhood Hits	1070	Shared Neighborhood Hits	62
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

AFF1_MOUSE
θ value	0.365318 (rank : 13)	NC score	0.039633 (rank : 340)
Query Neighborhood Hits	82	Target Neighborhood Hits	351	Shared Neighborhood Hits	7
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

M4K3_HUMAN
θ value	0.365318 (rank : 14)	NC score	0.070776 (rank : 30)
Query Neighborhood Hits	82	Target Neighborhood Hits	857	Shared Neighborhood Hits	61
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

E2AK4_HUMAN
θ value	0.47712 (rank : 15)	NC score	0.073695 (rank : 23)
Query Neighborhood Hits	82	Target Neighborhood Hits	1012	Shared Neighborhood Hits	62
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

E2AK4_MOUSE
θ value	0.47712 (rank : 16)	NC score	0.074583 (rank : 22)
Query Neighborhood Hits	82	Target Neighborhood Hits	984	Shared Neighborhood Hits	62
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

AKT2_MOUSE
θ value	0.62314 (rank : 17)	NC score	0.070870 (rank : 29)
Query Neighborhood Hits	82	Target Neighborhood Hits	875	Shared Neighborhood Hits	60
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

CP053_HUMAN
θ value	0.62314 (rank : 18)	NC score	0.056679 (rank : 146)
Query Neighborhood Hits	82	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BTK6	Gene names	C16orf53
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf53.

KPCD_HUMAN
θ value	0.62314 (rank : 19)	NC score	0.076471 (rank : 17)
Query Neighborhood Hits	82	Target Neighborhood Hits	900	Shared Neighborhood Hits	61
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_MOUSE
θ value	0.62314 (rank : 20)	NC score	0.075981 (rank : 20)
Query Neighborhood Hits	82	Target Neighborhood Hits	888	Shared Neighborhood Hits	61
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCT_HUMAN
θ value	0.62314 (rank : 21)	NC score	0.076136 (rank : 19)
Query Neighborhood Hits	82	Target Neighborhood Hits	897	Shared Neighborhood Hits	61
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

ERCC5_MOUSE
θ value	0.813845 (rank : 22)	NC score	0.042148 (rank : 337)
Query Neighborhood Hits	82	Target Neighborhood Hits	206	Shared Neighborhood Hits	7
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

EXO1_HUMAN
θ value	0.813845 (rank : 23)	NC score	0.043008 (rank : 336)
Query Neighborhood Hits	82	Target Neighborhood Hits	82	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UQ84, O60545, O75214, O75466, Q5T396, Q96IJ1, Q9UG38, Q9UNW0	Gene names	EXO1, EXOI, HEX1
Domain Architecture	No domain graphic available
Description	Exonuclease 1 (EC 3.1.-.-) (hExo1) (Exonuclease I) (hExoI).

TSSK4_MOUSE
θ value	0.813845 (rank : 24)	NC score	0.062026 (rank : 92)
Query Neighborhood Hits	82	Target Neighborhood Hits	840	Shared Neighborhood Hits	61
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

IF39_MOUSE
θ value	1.06291 (rank : 25)	NC score	0.036691 (rank : 341)
Query Neighborhood Hits	82	Target Neighborhood Hits	206	Shared Neighborhood Hits	6
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

KPCA_MOUSE
θ value	1.06291 (rank : 26)	NC score	0.076463 (rank : 18)
Query Neighborhood Hits	82	Target Neighborhood Hits	1067	Shared Neighborhood Hits	62
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KS6B2_MOUSE
θ value	1.06291 (rank : 27)	NC score	0.069108 (rank : 39)
Query Neighborhood Hits	82	Target Neighborhood Hits	871	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

MASTL_HUMAN
θ value	1.06291 (rank : 28)	NC score	0.077932 (rank : 11)
Query Neighborhood Hits	82	Target Neighborhood Hits	894	Shared Neighborhood Hits	62
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MASTL_MOUSE
θ value	1.06291 (rank : 29)	NC score	0.076918 (rank : 16)
Query Neighborhood Hits	82	Target Neighborhood Hits	862	Shared Neighborhood Hits	62
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

CHK1_MOUSE
θ value	1.38821 (rank : 30)	NC score	0.060898 (rank : 113)
Query Neighborhood Hits	82	Target Neighborhood Hits	839	Shared Neighborhood Hits	61
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

HUNK_MOUSE
θ value	1.38821 (rank : 31)	NC score	0.061417 (rank : 102)
Query Neighborhood Hits	82	Target Neighborhood Hits	874	Shared Neighborhood Hits	62
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

KPCE_HUMAN
θ value	1.38821 (rank : 32)	NC score	0.077907 (rank : 12)
Query Neighborhood Hits	82	Target Neighborhood Hits	906	Shared Neighborhood Hits	61
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_MOUSE
θ value	1.38821 (rank : 33)	NC score	0.077799 (rank : 13)
Query Neighborhood Hits	82	Target Neighborhood Hits	906	Shared Neighborhood Hits	62
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCG_HUMAN
θ value	1.38821 (rank : 34)	NC score	0.077123 (rank : 14)
Query Neighborhood Hits	82	Target Neighborhood Hits	1126	Shared Neighborhood Hits	62
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
θ value	1.38821 (rank : 35)	NC score	0.077056 (rank : 15)
Query Neighborhood Hits	82	Target Neighborhood Hits	1123	Shared Neighborhood Hits	62
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

PAK7_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.060563 (rank : 120)
Query Neighborhood Hits	82	Target Neighborhood Hits	875	Shared Neighborhood Hits	60
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

AKT2_HUMAN
θ value	1.81305 (rank : 37)	NC score	0.069832 (rank : 32)
Query Neighborhood Hits	82	Target Neighborhood Hits	878	Shared Neighborhood Hits	60
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

HUNK_HUMAN
θ value	1.81305 (rank : 38)	NC score	0.060961 (rank : 111)
Query Neighborhood Hits	82	Target Neighborhood Hits	884	Shared Neighborhood Hits	62
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

KKCC2_HUMAN
θ value	1.81305 (rank : 39)	NC score	0.063807 (rank : 77)
Query Neighborhood Hits	82	Target Neighborhood Hits	852	Shared Neighborhood Hits	61
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	1.81305 (rank : 40)	NC score	0.063865 (rank : 76)
Query Neighborhood Hits	82	Target Neighborhood Hits	855	Shared Neighborhood Hits	61
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPCT_MOUSE
θ value	1.81305 (rank : 41)	NC score	0.074812 (rank : 21)
Query Neighborhood Hits	82	Target Neighborhood Hits	895	Shared Neighborhood Hits	61
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

M4K2_MOUSE
θ value	1.81305 (rank : 42)	NC score	0.066713 (rank : 48)
Query Neighborhood Hits	82	Target Neighborhood Hits	843	Shared Neighborhood Hits	61
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

PAK7_MOUSE
θ value	1.81305 (rank : 43)	NC score	0.061332 (rank : 104)
Query Neighborhood Hits	82	Target Neighborhood Hits	875	Shared Neighborhood Hits	61
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

AKT3_HUMAN
θ value	2.36792 (rank : 44)	NC score	0.069754 (rank : 34)
Query Neighborhood Hits	82	Target Neighborhood Hits	872	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	2.36792 (rank : 45)	NC score	0.069758 (rank : 33)
Query Neighborhood Hits	82	Target Neighborhood Hits	872	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

RIPK1_MOUSE
θ value	2.36792 (rank : 46)	NC score	0.050891 (rank : 300)
Query Neighborhood Hits	82	Target Neighborhood Hits	874	Shared Neighborhood Hits	61
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

MAST4_HUMAN
θ value	3.0926 (rank : 47)	NC score	0.068415 (rank : 40)
Query Neighborhood Hits	82	Target Neighborhood Hits	1804	Shared Neighborhood Hits	64
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

CO5_MOUSE
θ value	4.03905 (rank : 48)	NC score	0.021899 (rank : 344)
Query Neighborhood Hits	82	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	P06684	Gene names	C5, Hc
Domain Architecture
Description	Complement C5 precursor (Hemolytic complement) [Contains: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain].

LATS1_HUMAN
θ value	4.03905 (rank : 49)	NC score	0.071096 (rank : 28)
Query Neighborhood Hits	82	Target Neighborhood Hits	1057	Shared Neighborhood Hits	61
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

LATS1_MOUSE
θ value	4.03905 (rank : 50)	NC score	0.071394 (rank : 26)
Query Neighborhood Hits	82	Target Neighborhood Hits	1027	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

GASP1_HUMAN
θ value	5.27518 (rank : 51)	NC score	0.013857 (rank : 350)
Query Neighborhood Hits	82	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q5JY77, O43168, Q96LA1	Gene names	GPRASP1, GASP, KIAA0443
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor-associated sorting protein 1 (GASP-1).

IP3KB_HUMAN
θ value	5.27518 (rank : 52)	NC score	0.017225 (rank : 347)
Query Neighborhood Hits	82	Target Neighborhood Hits	124	Shared Neighborhood Hits	4
SwissProt Accessions	P27987, Q5VWL9, Q5VWM0, Q96BZ2, Q96JS1, Q9UH47	Gene names	ITPKB
Domain Architecture
Description	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase B) (IP3K B) (IP3 3-kinase B) (IP3K-B).

LEO1_MOUSE
θ value	5.27518 (rank : 53)	NC score	0.012001 (rank : 352)
Query Neighborhood Hits	82	Target Neighborhood Hits	946	Shared Neighborhood Hits	8
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

MAST3_HUMAN
θ value	5.27518 (rank : 54)	NC score	0.067731 (rank : 45)
Query Neighborhood Hits	82	Target Neighborhood Hits	1128	Shared Neighborhood Hits	61
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

NMD3B_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.009147 (rank : 353)
Query Neighborhood Hits	82	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	O60391, Q5EAK7, Q7RTW9	Gene names	GRIN3B
Domain Architecture	No domain graphic available
Description	Glutamate [NMDA] receptor subunit 3B precursor (N-methyl-D-aspartate receptor subtype NR3B) (NR3B) (NMDAR3B).

PELO_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.022949 (rank : 343)
Query Neighborhood Hits	82	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q80X73, Q6PG91, Q91UZ2	Gene names	Pelo
Domain Architecture	No domain graphic available
Description	Protein pelota homolog.

M3K14_HUMAN
θ value	6.88961 (rank : 57)	NC score	0.057425 (rank : 142)
Query Neighborhood Hits	82	Target Neighborhood Hits	887	Shared Neighborhood Hits	61
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

M4K2_HUMAN
θ value	6.88961 (rank : 58)	NC score	0.064139 (rank : 72)
Query Neighborhood Hits	82	Target Neighborhood Hits	850	Shared Neighborhood Hits	61
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

PI4KA_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.012933 (rank : 351)
Query Neighborhood Hits	82	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

RIPK1_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.049929 (rank : 335)
Query Neighborhood Hits	82	Target Neighborhood Hits	891	Shared Neighborhood Hits	60
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

ROCK2_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.058345 (rank : 130)
Query Neighborhood Hits	82	Target Neighborhood Hits	2073	Shared Neighborhood Hits	60
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

ROCK2_MOUSE
θ value	6.88961 (rank : 62)	NC score	0.058035 (rank : 138)
Query Neighborhood Hits	82	Target Neighborhood Hits	2072	Shared Neighborhood Hits	60
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

SYT10_HUMAN
θ value	6.88961 (rank : 63)	NC score	0.018332 (rank : 346)
Query Neighborhood Hits	82	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

TF3B_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.017092 (rank : 348)
Query Neighborhood Hits	82	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CFK2	Gene names	Brf1
Domain Architecture	No domain graphic available
Description	Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B- related factor 1) (BRF-1).

AKT1_HUMAN
θ value	8.99809 (rank : 65)	NC score	0.069202 (rank : 38)
Query Neighborhood Hits	82	Target Neighborhood Hits	885	Shared Neighborhood Hits	60
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
θ value	8.99809 (rank : 66)	NC score	0.069368 (rank : 35)
Query Neighborhood Hits	82	Target Neighborhood Hits	878	Shared Neighborhood Hits	60
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

IKAP_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.019620 (rank : 345)
Query Neighborhood Hits	82	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	O95163, Q9H327, Q9UG87	Gene names	IKBKAP, IKAP
Domain Architecture
Description	IkappaB kinase complex-associated protein (IKK complex-associated protein) (p150).

IWS1_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.015353 (rank : 349)
Query Neighborhood Hits	82	Target Neighborhood Hits	1241	Shared Neighborhood Hits	13
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

KPCZ_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.071431 (rank : 25)
Query Neighborhood Hits	82	Target Neighborhood Hits	884	Shared Neighborhood Hits	60
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.071484 (rank : 24)
Query Neighborhood Hits	82	Target Neighborhood Hits	882	Shared Neighborhood Hits	60
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KS6B2_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.064973 (rank : 66)
Query Neighborhood Hits	82	Target Neighborhood Hits	858	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

M4K5_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.064488 (rank : 70)
Query Neighborhood Hits	82	Target Neighborhood Hits	845	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

M4K5_MOUSE
θ value	8.99809 (rank : 73)	NC score	0.064765 (rank : 68)
Query Neighborhood Hits	82	Target Neighborhood Hits	839	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

MAST1_HUMAN
θ value	8.99809 (rank : 74)	NC score	0.067957 (rank : 43)
Query Neighborhood Hits	82	Target Neighborhood Hits	1146	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
θ value	8.99809 (rank : 75)	NC score	0.068108 (rank : 42)
Query Neighborhood Hits	82	Target Neighborhood Hits	1123	Shared Neighborhood Hits	61
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

PAK6_HUMAN
θ value	8.99809 (rank : 76)	NC score	0.057221 (rank : 144)
Query Neighborhood Hits	82	Target Neighborhood Hits	915	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PDPK1_HUMAN
θ value	8.99809 (rank : 77)	NC score	0.061123 (rank : 110)
Query Neighborhood Hits	82	Target Neighborhood Hits	851	Shared Neighborhood Hits	61
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
θ value	8.99809 (rank : 78)	NC score	0.061134 (rank : 109)
Query Neighborhood Hits	82	Target Neighborhood Hits	852	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PRPK_MOUSE
θ value	8.99809 (rank : 79)	NC score	0.030704 (rank : 342)
Query Neighborhood Hits	82	Target Neighborhood Hits	139	Shared Neighborhood Hits	18
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

TNI3K_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.041128 (rank : 339)
Query Neighborhood Hits	82	Target Neighborhood Hits	1084	Shared Neighborhood Hits	61
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	8.99809 (rank : 81)	NC score	0.041842 (rank : 338)
Query Neighborhood Hits	82	Target Neighborhood Hits	1079	Shared Neighborhood Hits	61
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TTK_MOUSE
θ value	8.99809 (rank : 82)	NC score	0.053438 (rank : 209)
Query Neighborhood Hits	82	Target Neighborhood Hits	803	Shared Neighborhood Hits	61
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

AAPK1_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.053846 (rank : 192)
Query Neighborhood Hits	82	Target Neighborhood Hits	842	Shared Neighborhood Hits	59
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.053970 (rank : 189)
Query Neighborhood Hits	82	Target Neighborhood Hits	843	Shared Neighborhood Hits	59
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK2_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.053932 (rank : 190)
Query Neighborhood Hits	82	Target Neighborhood Hits	843	Shared Neighborhood Hits	59
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

ARBK1_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.062440 (rank : 88)
Query Neighborhood Hits	82	Target Neighborhood Hits	859	Shared Neighborhood Hits	59
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.062749 (rank : 84)
Query Neighborhood Hits	82	Target Neighborhood Hits	849	Shared Neighborhood Hits	59
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

ARBK2_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.062884 (rank : 82)
Query Neighborhood Hits	82	Target Neighborhood Hits	849	Shared Neighborhood Hits	59
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

AURKB_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.055284 (rank : 162)
Query Neighborhood Hits	82	Target Neighborhood Hits	847	Shared Neighborhood Hits	59
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

AURKB_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.055254 (rank : 163)
Query Neighborhood Hits	82	Target Neighborhood Hits	858	Shared Neighborhood Hits	59
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

AURKC_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.054394 (rank : 181)
Query Neighborhood Hits	82	Target Neighborhood Hits	847	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

AURKC_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.054707 (rank : 177)
Query Neighborhood Hits	82	Target Neighborhood Hits	844	Shared Neighborhood Hits	59
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

BRSK1_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.051787 (rank : 274)
Query Neighborhood Hits	82	Target Neighborhood Hits	942	Shared Neighborhood Hits	59
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

BRSK2_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.051431 (rank : 286)
Query Neighborhood Hits	82	Target Neighborhood Hits	897	Shared Neighborhood Hits	59
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

CHK1_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.055526 (rank : 158)
Query Neighborhood Hits	82	Target Neighborhood Hits	843	Shared Neighborhood Hits	60
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK2_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.052213 (rank : 260)
Query Neighborhood Hits	82	Target Neighborhood Hits	859	Shared Neighborhood Hits	59
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

CHK2_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.051723 (rank : 278)
Query Neighborhood Hits	82	Target Neighborhood Hits	860	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

CTRO_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.054583 (rank : 178)
Query Neighborhood Hits	82	Target Neighborhood Hits	2092	Shared Neighborhood Hits	61
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CTRO_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.052452 (rank : 249)
Query Neighborhood Hits	82	Target Neighborhood Hits	2344	Shared Neighborhood Hits	61
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

DAPK2_MOUSE
θ value	θ > 10 (rank : 100)	NC score	0.050239 (rank : 330)
Query Neighborhood Hits	82	Target Neighborhood Hits	834	Shared Neighborhood Hits	60
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DCAK3_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.050743 (rank : 307)
Query Neighborhood Hits	82	Target Neighborhood Hits	888	Shared Neighborhood Hits	60
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

DCAK3_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.050680 (rank : 310)
Query Neighborhood Hits	82	Target Neighborhood Hits	922	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

DMPK_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.065423 (rank : 55)
Query Neighborhood Hits	82	Target Neighborhood Hits	944	Shared Neighborhood Hits	59
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

DMPK_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.065132 (rank : 62)
Query Neighborhood Hits	82	Target Neighborhood Hits	908	Shared Neighborhood Hits	59
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

E2AK1_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.050528 (rank : 316)
Query Neighborhood Hits	82	Target Neighborhood Hits	821	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK2_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.051699 (rank : 279)
Query Neighborhood Hits	82	Target Neighborhood Hits	864	Shared Neighborhood Hits	60
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

F5006_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.062336 (rank : 91)
Query Neighborhood Hits	82	Target Neighborhood Hits	794	Shared Neighborhood Hits	60
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

F5006_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.063435 (rank : 78)
Query Neighborhood Hits	82	Target Neighborhood Hits	793	Shared Neighborhood Hits	60
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

GRK4_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.062346 (rank : 90)
Query Neighborhood Hits	82	Target Neighborhood Hits	822	Shared Neighborhood Hits	59
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

GRK4_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.061538 (rank : 98)
Query Neighborhood Hits	82	Target Neighborhood Hits	808	Shared Neighborhood Hits	59
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

GRK5_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.061386 (rank : 103)
Query Neighborhood Hits	82	Target Neighborhood Hits	819	Shared Neighborhood Hits	59
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.061260 (rank : 106)
Query Neighborhood Hits	82	Target Neighborhood Hits	823	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK6_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.060165 (rank : 124)
Query Neighborhood Hits	82	Target Neighborhood Hits	823	Shared Neighborhood Hits	59
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK6_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.060407 (rank : 123)
Query Neighborhood Hits	82	Target Neighborhood Hits	820	Shared Neighborhood Hits	59
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK7_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.061233 (rank : 107)
Query Neighborhood Hits	82	Target Neighborhood Hits	820	Shared Neighborhood Hits	59
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

HTSF1_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.053566 (rank : 201)
Query Neighborhood Hits	82	Target Neighborhood Hits	425	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGC0, Q1WWK0, Q9CT41, Q9DAU3	Gene names	Htatsf1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 homolog.

K0999_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.050069 (rank : 332)
Query Neighborhood Hits	82	Target Neighborhood Hits	899	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KAPCA_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.061514 (rank : 100)
Query Neighborhood Hits	82	Target Neighborhood Hits	838	Shared Neighborhood Hits	59
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCA_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.061688 (rank : 96)
Query Neighborhood Hits	82	Target Neighborhood Hits	836	Shared Neighborhood Hits	59
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCB_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.061791 (rank : 95)
Query Neighborhood Hits	82	Target Neighborhood Hits	837	Shared Neighborhood Hits	59
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCB_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.062020 (rank : 93)
Query Neighborhood Hits	82	Target Neighborhood Hits	836	Shared Neighborhood Hits	59
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCG_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.060548 (rank : 121)
Query Neighborhood Hits	82	Target Neighborhood Hits	845	Shared Neighborhood Hits	59
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KCC1A_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.052272 (rank : 257)
Query Neighborhood Hits	82	Target Neighborhood Hits	846	Shared Neighborhood Hits	59
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.052248 (rank : 258)
Query Neighborhood Hits	82	Target Neighborhood Hits	845	Shared Neighborhood Hits	59
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1B_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.052342 (rank : 255)
Query Neighborhood Hits	82	Target Neighborhood Hits	842	Shared Neighborhood Hits	60
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1B_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.052194 (rank : 262)
Query Neighborhood Hits	82	Target Neighborhood Hits	842	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1D_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.053459 (rank : 208)
Query Neighborhood Hits	82	Target Neighborhood Hits	846	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.053471 (rank : 204)
Query Neighborhood Hits	82	Target Neighborhood Hits	847	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1G_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.052474 (rank : 245)
Query Neighborhood Hits	82	Target Neighborhood Hits	850	Shared Neighborhood Hits	60
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.052536 (rank : 243)
Query Neighborhood Hits	82	Target Neighborhood Hits	851	Shared Neighborhood Hits	60
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC2A_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.050349 (rank : 327)
Query Neighborhood Hits	82	Target Neighborhood Hits	829	Shared Neighborhood Hits	59
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC4_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.051313 (rank : 288)
Query Neighborhood Hits	82	Target Neighborhood Hits	841	Shared Neighborhood Hits	60
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC4_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.051806 (rank : 273)
Query Neighborhood Hits	82	Target Neighborhood Hits	899	Shared Neighborhood Hits	63
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KGP1A_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.060915 (rank : 112)
Query Neighborhood Hits	82	Target Neighborhood Hits	901	Shared Neighborhood Hits	59
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.060864 (rank : 115)
Query Neighborhood Hits	82	Target Neighborhood Hits	921	Shared Neighborhood Hits	59
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.060872 (rank : 114)
Query Neighborhood Hits	82	Target Neighborhood Hits	922	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP2_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.058392 (rank : 129)
Query Neighborhood Hits	82	Target Neighborhood Hits	1023	Shared Neighborhood Hits	59
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.058674 (rank : 126)
Query Neighborhood Hits	82	Target Neighborhood Hits	1029	Shared Neighborhood Hits	59
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KKCC1_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.058054 (rank : 137)
Query Neighborhood Hits	82	Target Neighborhood Hits	858	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC1_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.057971 (rank : 139)
Query Neighborhood Hits	82	Target Neighborhood Hits	866	Shared Neighborhood Hits	60
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KPCI_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.069312 (rank : 36)
Query Neighborhood Hits	82	Target Neighborhood Hits	885	Shared Neighborhood Hits	59
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.069276 (rank : 37)
Query Neighborhood Hits	82	Target Neighborhood Hits	888	Shared Neighborhood Hits	59
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KPCL_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.071363 (rank : 27)
Query Neighborhood Hits	82	Target Neighborhood Hits	887	Shared Neighborhood Hits	59
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCL_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.070615 (rank : 31)
Query Neighborhood Hits	82	Target Neighborhood Hits	891	Shared Neighborhood Hits	60
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPSH1_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.052468 (rank : 248)
Query Neighborhood Hits	82	Target Neighborhood Hits	842	Shared Neighborhood Hits	60
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.052550 (rank : 241)
Query Neighborhood Hits	82	Target Neighborhood Hits	839	Shared Neighborhood Hits	60
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH2_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.052324 (rank : 256)
Query Neighborhood Hits	82	Target Neighborhood Hits	822	Shared Neighborhood Hits	60
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KS6A1_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.058275 (rank : 131)
Query Neighborhood Hits	82	Target Neighborhood Hits	854	Shared Neighborhood Hits	59
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A1_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.058454 (rank : 128)
Query Neighborhood Hits	82	Target Neighborhood Hits	850	Shared Neighborhood Hits	59
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.058547 (rank : 127)
Query Neighborhood Hits	82	Target Neighborhood Hits	857	Shared Neighborhood Hits	59
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A2_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.058263 (rank : 132)
Query Neighborhood Hits	82	Target Neighborhood Hits	858	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KS6A3_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.058246 (rank : 134)
Query Neighborhood Hits	82	Target Neighborhood Hits	859	Shared Neighborhood Hits	59
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.058249 (rank : 133)
Query Neighborhood Hits	82	Target Neighborhood Hits	860	Shared Neighborhood Hits	59
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A4_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.061834 (rank : 94)
Query Neighborhood Hits	82	Target Neighborhood Hits	868	Shared Neighborhood Hits	60
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

KS6A4_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.061637 (rank : 97)
Query Neighborhood Hits	82	Target Neighborhood Hits	866	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

KS6A5_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.060087 (rank : 125)
Query Neighborhood Hits	82	Target Neighborhood Hits	855	Shared Neighborhood Hits	60
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

KS6A5_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.062596 (rank : 85)
Query Neighborhood Hits	82	Target Neighborhood Hits	854	Shared Neighborhood Hits	60
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

KS6A6_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.058167 (rank : 135)
Query Neighborhood Hits	82	Target Neighborhood Hits	853	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KS6B1_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.063996 (rank : 73)
Query Neighborhood Hits	82	Target Neighborhood Hits	850	Shared Neighborhood Hits	59
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.063996 (rank : 74)
Query Neighborhood Hits	82	Target Neighborhood Hits	849	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6C1_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.062811 (rank : 83)
Query Neighborhood Hits	82	Target Neighborhood Hits	682	Shared Neighborhood Hits	57
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

KS6C1_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.062471 (rank : 87)
Query Neighborhood Hits	82	Target Neighborhood Hits	700	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

LATS2_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.067337 (rank : 47)
Query Neighborhood Hits	82	Target Neighborhood Hits	884	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

LATS2_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.067732 (rank : 44)
Query Neighborhood Hits	82	Target Neighborhood Hits	879	Shared Neighborhood Hits	60
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

M3K14_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.054859 (rank : 174)
Query Neighborhood Hits	82	Target Neighborhood Hits	889	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

M3K15_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.052356 (rank : 252)
Query Neighborhood Hits	82	Target Neighborhood Hits	914	Shared Neighborhood Hits	59
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K1_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.051290 (rank : 289)
Query Neighborhood Hits	82	Target Neighborhood Hits	952	Shared Neighborhood Hits	59
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K2_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.053423 (rank : 213)
Query Neighborhood Hits	82	Target Neighborhood Hits	849	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K2_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.053048 (rank : 221)
Query Neighborhood Hits	82	Target Neighborhood Hits	846	Shared Neighborhood Hits	59
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K3_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.052547 (rank : 242)
Query Neighborhood Hits	82	Target Neighborhood Hits	885	Shared Neighborhood Hits	59
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K3_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.052603 (rank : 240)
Query Neighborhood Hits	82	Target Neighborhood Hits	876	Shared Neighborhood Hits	59
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K4_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.050927 (rank : 298)
Query Neighborhood Hits	82	Target Neighborhood Hits	911	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.050812 (rank : 305)
Query Neighborhood Hits	82	Target Neighborhood Hits	924	Shared Neighborhood Hits	59
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

M3K5_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.051962 (rank : 268)
Query Neighborhood Hits	82	Target Neighborhood Hits	868	Shared Neighborhood Hits	59
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.052021 (rank : 266)
Query Neighborhood Hits	82	Target Neighborhood Hits	867	Shared Neighborhood Hits	59
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K6_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.053044 (rank : 222)
Query Neighborhood Hits	82	Target Neighborhood Hits	889	Shared Neighborhood Hits	60
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M3K8_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.053714 (rank : 197)
Query Neighborhood Hits	82	Target Neighborhood Hits	807	Shared Neighborhood Hits	57
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K8_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.054106 (rank : 186)
Query Neighborhood Hits	82	Target Neighborhood Hits	815	Shared Neighborhood Hits	58
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M4K1_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.056695 (rank : 145)
Query Neighborhood Hits	82	Target Neighborhood Hits	884	Shared Neighborhood Hits	59
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K1_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.057237 (rank : 143)
Query Neighborhood Hits	82	Target Neighborhood Hits	858	Shared Neighborhood Hits	59
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K4_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.055801 (rank : 153)
Query Neighborhood Hits	82	Target Neighborhood Hits	1589	Shared Neighborhood Hits	61
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.056069 (rank : 149)
Query Neighborhood Hits	82	Target Neighborhood Hits	1560	Shared Neighborhood Hits	62
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MAPK3_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.050547 (rank : 315)
Query Neighborhood Hits	82	Target Neighborhood Hits	807	Shared Neighborhood Hits	57
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

MAPK3_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.050519 (rank : 317)
Query Neighborhood Hits	82	Target Neighborhood Hits	811	Shared Neighborhood Hits	57
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MAPK5_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.050486 (rank : 320)
Query Neighborhood Hits	82	Target Neighborhood Hits	795	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MAPK5_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.050712 (rank : 308)
Query Neighborhood Hits	82	Target Neighborhood Hits	799	Shared Neighborhood Hits	57
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

MARK1_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.051742 (rank : 275)
Query Neighborhood Hits	82	Target Neighborhood Hits	887	Shared Neighborhood Hits	59
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK1_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.051895 (rank : 271)
Query Neighborhood Hits	82	Target Neighborhood Hits	886	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK2_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.051963 (rank : 267)
Query Neighborhood Hits	82	Target Neighborhood Hits	1056	Shared Neighborhood Hits	60
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK2_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.052062 (rank : 265)
Query Neighborhood Hits	82	Target Neighborhood Hits	1018	Shared Neighborhood Hits	59
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MARK3_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.051280 (rank : 290)
Query Neighborhood Hits	82	Target Neighborhood Hits	893	Shared Neighborhood Hits	59
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK3_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.051726 (rank : 277)
Query Neighborhood Hits	82	Target Neighborhood Hits	919	Shared Neighborhood Hits	59
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK4_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.051519 (rank : 284)
Query Neighborhood Hits	82	Target Neighborhood Hits	886	Shared Neighborhood Hits	59
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.051510 (rank : 285)
Query Neighborhood Hits	82	Target Neighborhood Hits	898	Shared Neighborhood Hits	59
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MAST2_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.065602 (rank : 52)
Query Neighborhood Hits	82	Target Neighborhood Hits	1189	Shared Neighborhood Hits	61
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.065371 (rank : 57)
Query Neighborhood Hits	82	Target Neighborhood Hits	1110	Shared Neighborhood Hits	60
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MELK_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.052375 (rank : 251)
Query Neighborhood Hits	82	Target Neighborhood Hits	847	Shared Neighborhood Hits	59
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MELK_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.052832 (rank : 229)
Query Neighborhood Hits	82	Target Neighborhood Hits	860	Shared Neighborhood Hits	59
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

MINK1_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.056003 (rank : 151)
Query Neighborhood Hits	82	Target Neighborhood Hits	1477	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.056027 (rank : 150)
Query Neighborhood Hits	82	Target Neighborhood Hits	1451	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MKNK1_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.051941 (rank : 270)
Query Neighborhood Hits	82	Target Neighborhood Hits	701	Shared Neighborhood Hits	59
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MKNK1_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.053103 (rank : 220)
Query Neighborhood Hits	82	Target Neighborhood Hits	811	Shared Neighborhood Hits	60
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MKNK2_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.051840 (rank : 272)
Query Neighborhood Hits	82	Target Neighborhood Hits	821	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MKNK2_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.051524 (rank : 283)
Query Neighborhood Hits	82	Target Neighborhood Hits	819	Shared Neighborhood Hits	58
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MP2K1_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.052866 (rank : 227)
Query Neighborhood Hits	82	Target Neighborhood Hits	826	Shared Neighborhood Hits	59
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.052923 (rank : 226)
Query Neighborhood Hits	82	Target Neighborhood Hits	826	Shared Neighborhood Hits	59
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.051958 (rank : 269)
Query Neighborhood Hits	82	Target Neighborhood Hits	830	Shared Neighborhood Hits	59
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.052087 (rank : 263)
Query Neighborhood Hits	82	Target Neighborhood Hits	828	Shared Neighborhood Hits	59
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.052062 (rank : 264)
Query Neighborhood Hits	82	Target Neighborhood Hits	825	Shared Neighborhood Hits	59
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.052731 (rank : 234)
Query Neighborhood Hits	82	Target Neighborhood Hits	826	Shared Neighborhood Hits	59
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K4_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.050513 (rank : 318)
Query Neighborhood Hits	82	Target Neighborhood Hits	832	Shared Neighborhood Hits	59
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.050548 (rank : 314)
Query Neighborhood Hits	82	Target Neighborhood Hits	833	Shared Neighborhood Hits	59
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K5_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.053370 (rank : 216)
Query Neighborhood Hits	82	Target Neighborhood Hits	837	Shared Neighborhood Hits	59
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.052820 (rank : 230)
Query Neighborhood Hits	82	Target Neighborhood Hits	840	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K7_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.055525 (rank : 159)
Query Neighborhood Hits	82	Target Neighborhood Hits	833	Shared Neighborhood Hits	60
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MRCKA_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.056089 (rank : 148)
Query Neighborhood Hits	82	Target Neighborhood Hits	1999	Shared Neighborhood Hits	60
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

MRCKB_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.054379 (rank : 182)
Query Neighborhood Hits	82	Target Neighborhood Hits	2239	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MRCKB_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.055174 (rank : 164)
Query Neighborhood Hits	82	Target Neighborhood Hits	2180	Shared Neighborhood Hits	61
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MRCKG_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.060590 (rank : 118)
Query Neighborhood Hits	82	Target Neighborhood Hits	1519	Shared Neighborhood Hits	59
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRCKG_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.060568 (rank : 119)
Query Neighborhood Hits	82	Target Neighborhood Hits	1466	Shared Neighborhood Hits	59
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MST4_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.055632 (rank : 157)
Query Neighborhood Hits	82	Target Neighborhood Hits	852	Shared Neighborhood Hits	60
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.055641 (rank : 156)
Query Neighborhood Hits	82	Target Neighborhood Hits	860	Shared Neighborhood Hits	60
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

NEK11_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.050395 (rank : 325)
Query Neighborhood Hits	82	Target Neighborhood Hits	1043	Shared Neighborhood Hits	60
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.050134 (rank : 331)
Query Neighborhood Hits	82	Target Neighborhood Hits	875	Shared Neighborhood Hits	59
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK1_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.050813 (rank : 304)
Query Neighborhood Hits	82	Target Neighborhood Hits	1129	Shared Neighborhood Hits	61
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.050402 (rank : 324)
Query Neighborhood Hits	82	Target Neighborhood Hits	1311	Shared Neighborhood Hits	63
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK2_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.050567 (rank : 313)
Query Neighborhood Hits	82	Target Neighborhood Hits	908	Shared Neighborhood Hits	59
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.051569 (rank : 282)
Query Neighborhood Hits	82	Target Neighborhood Hits	876	Shared Neighborhood Hits	59
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK3_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.052865 (rank : 228)
Query Neighborhood Hits	82	Target Neighborhood Hits	865	Shared Neighborhood Hits	59
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.053621 (rank : 200)
Query Neighborhood Hits	82	Target Neighborhood Hits	854	Shared Neighborhood Hits	59
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.051074 (rank : 296)
Query Neighborhood Hits	82	Target Neighborhood Hits	883	Shared Neighborhood Hits	59
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.051028 (rank : 297)
Query Neighborhood Hits	82	Target Neighborhood Hits	899	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NIM1_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.053363 (rank : 217)
Query Neighborhood Hits	82	Target Neighborhood Hits	850	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NIM1_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.053697 (rank : 198)
Query Neighborhood Hits	82	Target Neighborhood Hits	850	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NUAK1_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.052354 (rank : 253)
Query Neighborhood Hits	82	Target Neighborhood Hits	874	Shared Neighborhood Hits	59
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.052343 (rank : 254)
Query Neighborhood Hits	82	Target Neighborhood Hits	881	Shared Neighborhood Hits	59
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.053426 (rank : 212)
Query Neighborhood Hits	82	Target Neighborhood Hits	874	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NUAK2_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.053724 (rank : 196)
Query Neighborhood Hits	82	Target Neighborhood Hits	878	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

OXSR1_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.053908 (rank : 191)
Query Neighborhood Hits	82	Target Neighborhood Hits	874	Shared Neighborhood Hits	59
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.054128 (rank : 183)
Query Neighborhood Hits	82	Target Neighborhood Hits	865	Shared Neighborhood Hits	59
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAK1_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.054944 (rank : 171)
Query Neighborhood Hits	82	Target Neighborhood Hits	873	Shared Neighborhood Hits	59
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.055154 (rank : 165)
Query Neighborhood Hits	82	Target Neighborhood Hits	878	Shared Neighborhood Hits	59
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK2_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.054568 (rank : 180)
Query Neighborhood Hits	82	Target Neighborhood Hits	862	Shared Neighborhood Hits	59
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.054572 (rank : 179)
Query Neighborhood Hits	82	Target Neighborhood Hits	858	Shared Neighborhood Hits	59
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK3_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.055042 (rank : 168)
Query Neighborhood Hits	82	Target Neighborhood Hits	887	Shared Neighborhood Hits	60
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.055107 (rank : 166)
Query Neighborhood Hits	82	Target Neighborhood Hits	874	Shared Neighborhood Hits	60
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK4_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.057583 (rank : 141)
Query Neighborhood Hits	82	Target Neighborhood Hits	924	Shared Neighborhood Hits	59
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK4_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.058059 (rank : 136)
Query Neighborhood Hits	82	Target Neighborhood Hits	1098	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PASK_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.051213 (rank : 292)
Query Neighborhood Hits	82	Target Neighborhood Hits	857	Shared Neighborhood Hits	59
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

PASK_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.052605 (rank : 239)
Query Neighborhood Hits	82	Target Neighborhood Hits	867	Shared Neighborhood Hits	59
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PDK1L_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.052741 (rank : 232)
Query Neighborhood Hits	82	Target Neighborhood Hits	821	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.052636 (rank : 237)
Query Neighborhood Hits	82	Target Neighborhood Hits	821	Shared Neighborhood Hits	60
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PHKG1_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.050861 (rank : 302)
Query Neighborhood Hits	82	Target Neighborhood Hits	838	Shared Neighborhood Hits	59
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG1_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.051163 (rank : 294)
Query Neighborhood Hits	82	Target Neighborhood Hits	840	Shared Neighborhood Hits	60
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG2_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.050873 (rank : 301)
Query Neighborhood Hits	82	Target Neighborhood Hits	839	Shared Neighborhood Hits	59
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

PHKG2_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.050821 (rank : 303)
Query Neighborhood Hits	82	Target Neighborhood Hits	841	Shared Neighborhood Hits	59
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

PIM2_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.050701 (rank : 309)
Query Neighborhood Hits	82	Target Neighborhood Hits	809	Shared Neighborhood Hits	59
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

PIM3_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.050360 (rank : 326)
Query Neighborhood Hits	82	Target Neighborhood Hits	789	Shared Neighborhood Hits	59
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PIM3_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.050581 (rank : 312)
Query Neighborhood Hits	82	Target Neighborhood Hits	783	Shared Neighborhood Hits	59
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PINK1_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.052666 (rank : 236)
Query Neighborhood Hits	82	Target Neighborhood Hits	741	Shared Neighborhood Hits	59
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PINK1_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.052948 (rank : 225)
Query Neighborhood Hits	82	Target Neighborhood Hits	726	Shared Neighborhood Hits	59
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PKN1_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.065088 (rank : 63)
Query Neighborhood Hits	82	Target Neighborhood Hits	886	Shared Neighborhood Hits	59
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN1_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.065147 (rank : 61)
Query Neighborhood Hits	82	Target Neighborhood Hits	888	Shared Neighborhood Hits	59
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN2_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.064726 (rank : 69)
Query Neighborhood Hits	82	Target Neighborhood Hits	892	Shared Neighborhood Hits	59
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.064821 (rank : 67)
Query Neighborhood Hits	82	Target Neighborhood Hits	899	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN3_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.064165 (rank : 71)
Query Neighborhood Hits	82	Target Neighborhood Hits	893	Shared Neighborhood Hits	59
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN3_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.063929 (rank : 75)
Query Neighborhood Hits	82	Target Neighborhood Hits	1009	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PLK1_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.054977 (rank : 169)
Query Neighborhood Hits	82	Target Neighborhood Hits	849	Shared Neighborhood Hits	59
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK1_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.054878 (rank : 173)
Query Neighborhood Hits	82	Target Neighborhood Hits	849	Shared Neighborhood Hits	59
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK2_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.053430 (rank : 211)
Query Neighborhood Hits	82	Target Neighborhood Hits	854	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.053382 (rank : 215)
Query Neighborhood Hits	82	Target Neighborhood Hits	849	Shared Neighborhood Hits	59
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK3_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.052756 (rank : 231)
Query Neighborhood Hits	82	Target Neighborhood Hits	865	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PLK3_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.052707 (rank : 235)
Query Neighborhood Hits	82	Target Neighborhood Hits	863	Shared Neighborhood Hits	59
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PLK4_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.053469 (rank : 205)
Query Neighborhood Hits	82	Target Neighborhood Hits	884	Shared Neighborhood Hits	60
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.053463 (rank : 206)
Query Neighborhood Hits	82	Target Neighborhood Hits	879	Shared Neighborhood Hits	60
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PMYT1_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.054123 (rank : 184)
Query Neighborhood Hits	82	Target Neighborhood Hits	814	Shared Neighborhood Hits	59
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PMYT1_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.053308 (rank : 218)
Query Neighborhood Hits	82	Target Neighborhood Hits	910	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PRKX_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.061532 (rank : 99)
Query Neighborhood Hits	82	Target Neighborhood Hits	847	Shared Neighborhood Hits	59
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

PRKX_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.061304 (rank : 105)
Query Neighborhood Hits	82	Target Neighborhood Hits	846	Shared Neighborhood Hits	59
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

PRKY_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.060477 (rank : 122)
Query Neighborhood Hits	82	Target Neighborhood Hits	844	Shared Neighborhood Hits	59
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

PTMA_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.050914 (rank : 299)
Query Neighborhood Hits	82	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	P06454, Q15249, Q15592	Gene names	PTMA, TMSA
Domain Architecture	No domain graphic available
Description	Prothymosin alpha [Contains: Thymosin alpha-1].

RIPK5_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.050444 (rank : 322)
Query Neighborhood Hits	82	Target Neighborhood Hits	864	Shared Neighborhood Hits	59
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.050505 (rank : 319)
Query Neighborhood Hits	82	Target Neighborhood Hits	874	Shared Neighborhood Hits	59
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RK_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.063181 (rank : 80)
Query Neighborhood Hits	82	Target Neighborhood Hits	835	Shared Neighborhood Hits	59
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

RK_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.062351 (rank : 89)
Query Neighborhood Hits	82	Target Neighborhood Hits	829	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ROCK1_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.056160 (rank : 147)
Query Neighborhood Hits	82	Target Neighborhood Hits	2000	Shared Neighborhood Hits	59
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.054968 (rank : 170)
Query Neighborhood Hits	82	Target Neighborhood Hits	2126	Shared Neighborhood Hits	59
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

RPKL1_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.066215 (rank : 49)
Query Neighborhood Hits	82	Target Neighborhood Hits	708	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.067594 (rank : 46)
Query Neighborhood Hits	82	Target Neighborhood Hits	704	Shared Neighborhood Hits	58
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

SBK1_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.052498 (rank : 244)
Query Neighborhood Hits	82	Target Neighborhood Hits	828	Shared Neighborhood Hits	59
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SBK1_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.052234 (rank : 259)
Query Neighborhood Hits	82	Target Neighborhood Hits	824	Shared Neighborhood Hits	59
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SGK1_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.065284 (rank : 59)
Query Neighborhood Hits	82	Target Neighborhood Hits	848	Shared Neighborhood Hits	60
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK1_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.065618 (rank : 51)
Query Neighborhood Hits	82	Target Neighborhood Hits	848	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK2_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.065412 (rank : 56)
Query Neighborhood Hits	82	Target Neighborhood Hits	840	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK2_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.065167 (rank : 60)
Query Neighborhood Hits	82	Target Neighborhood Hits	833	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK3_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.065021 (rank : 65)
Query Neighborhood Hits	82	Target Neighborhood Hits	877	Shared Neighborhood Hits	59
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SGK3_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.065022 (rank : 64)
Query Neighborhood Hits	82	Target Neighborhood Hits	882	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

SLK_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.052211 (rank : 261)
Query Neighborhood Hits	82	Target Neighborhood Hits	1775	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.052439 (rank : 250)
Query Neighborhood Hits	82	Target Neighborhood Hits	1798	Shared Neighborhood Hits	63
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SN1L1_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.050245 (rank : 329)
Query Neighborhood Hits	82	Target Neighborhood Hits	911	Shared Neighborhood Hits	60
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

SN1L2_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.050003 (rank : 334)
Query Neighborhood Hits	82	Target Neighborhood Hits	944	Shared Neighborhood Hits	59
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

ST17A_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.052470 (rank : 247)
Query Neighborhood Hits	82	Target Neighborhood Hits	843	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.051741 (rank : 276)
Query Neighborhood Hits	82	Target Neighborhood Hits	833	Shared Neighborhood Hits	60
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST17B_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.051118 (rank : 295)
Query Neighborhood Hits	82	Target Neighborhood Hits	838	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST32A_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.062588 (rank : 86)
Query Neighborhood Hits	82	Target Neighborhood Hits	834	Shared Neighborhood Hits	60
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

ST32A_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.061228 (rank : 108)
Query Neighborhood Hits	82	Target Neighborhood Hits	833	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

ST32B_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.063397 (rank : 79)
Query Neighborhood Hits	82	Target Neighborhood Hits	830	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

ST32B_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.063000 (rank : 81)
Query Neighborhood Hits	82	Target Neighborhood Hits	828	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

ST32C_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.060689 (rank : 116)
Query Neighborhood Hits	82	Target Neighborhood Hits	832	Shared Neighborhood Hits	60
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

ST32C_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.060604 (rank : 117)
Query Neighborhood Hits	82	Target Neighborhood Hits	824	Shared Neighborhood Hits	59
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

ST38L_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.065358 (rank : 58)
Query Neighborhood Hits	82	Target Neighborhood Hits	824	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

ST38L_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.065831 (rank : 50)
Query Neighborhood Hits	82	Target Neighborhood Hits	821	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

STK10_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.051364 (rank : 287)
Query Neighborhood Hits	82	Target Neighborhood Hits	1921	Shared Neighborhood Hits	60
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK11_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.053491 (rank : 203)
Query Neighborhood Hits	82	Target Neighborhood Hits	831	Shared Neighborhood Hits	59
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

STK24_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.054772 (rank : 176)
Query Neighborhood Hits	82	Target Neighborhood Hits	853	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.054794 (rank : 175)
Query Neighborhood Hits	82	Target Neighborhood Hits	856	Shared Neighborhood Hits	59
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.055470 (rank : 161)
Query Neighborhood Hits	82	Target Neighborhood Hits	853	Shared Neighborhood Hits	59
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.055524 (rank : 160)
Query Neighborhood Hits	82	Target Neighborhood Hits	851	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK33_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.052471 (rank : 246)
Query Neighborhood Hits	82	Target Neighborhood Hits	879	Shared Neighborhood Hits	60
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

STK35_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.051206 (rank : 293)
Query Neighborhood Hits	82	Target Neighborhood Hits	825	Shared Neighborhood Hits	60
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

STK36_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.051681 (rank : 280)
Query Neighborhood Hits	82	Target Neighborhood Hits	896	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.050418 (rank : 323)
Query Neighborhood Hits	82	Target Neighborhood Hits	877	Shared Neighborhood Hits	60
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK38_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.065457 (rank : 54)
Query Neighborhood Hits	82	Target Neighborhood Hits	840	Shared Neighborhood Hits	59
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.065466 (rank : 53)
Query Neighborhood Hits	82	Target Neighborhood Hits	838	Shared Neighborhood Hits	59
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK39_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.053796 (rank : 193)
Query Neighborhood Hits	82	Target Neighborhood Hits	882	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.055707 (rank : 155)
Query Neighborhood Hits	82	Target Neighborhood Hits	915	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK3_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.053741 (rank : 195)
Query Neighborhood Hits	82	Target Neighborhood Hits	861	Shared Neighborhood Hits	59
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK3_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.053432 (rank : 210)
Query Neighborhood Hits	82	Target Neighborhood Hits	869	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK40_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.055777 (rank : 154)
Query Neighborhood Hits	82	Target Neighborhood Hits	751	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.055922 (rank : 152)
Query Neighborhood Hits	82	Target Neighborhood Hits	751	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

STK4_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.053014 (rank : 223)
Query Neighborhood Hits	82	Target Neighborhood Hits	870	Shared Neighborhood Hits	59
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.052989 (rank : 224)
Query Neighborhood Hits	82	Target Neighborhood Hits	873	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK6_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.053460 (rank : 207)
Query Neighborhood Hits	82	Target Neighborhood Hits	916	Shared Neighborhood Hits	59
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

STK6_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.053641 (rank : 199)
Query Neighborhood Hits	82	Target Neighborhood Hits	886	Shared Neighborhood Hits	59
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

TAOK3_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.050047 (rank : 333)
Query Neighborhood Hits	82	Target Neighborhood Hits	1494	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TRIB1_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.053229 (rank : 219)
Query Neighborhood Hits	82	Target Neighborhood Hits	598	Shared Neighborhood Hits	53
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB1_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.052615 (rank : 238)
Query Neighborhood Hits	82	Target Neighborhood Hits	593	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

TRIB2_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.053519 (rank : 202)
Query Neighborhood Hits	82	Target Neighborhood Hits	657	Shared Neighborhood Hits	56
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.053416 (rank : 214)
Query Neighborhood Hits	82	Target Neighborhood Hits	653	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB3_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.053999 (rank : 188)
Query Neighborhood Hits	82	Target Neighborhood Hits	519	Shared Neighborhood Hits	53
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

TRIB3_MOUSE
θ value	θ > 10 (rank : 341)	NC score	0.055080 (rank : 167)
Query Neighborhood Hits	82	Target Neighborhood Hits	578	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

TSSK1_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.054123 (rank : 185)
Query Neighborhood Hits	82	Target Neighborhood Hits	840	Shared Neighborhood Hits	60
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK1_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.051669 (rank : 281)
Query Neighborhood Hits	82	Target Neighborhood Hits	835	Shared Neighborhood Hits	60
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK2_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.053763 (rank : 194)
Query Neighborhood Hits	82	Target Neighborhood Hits	826	Shared Neighborhood Hits	60
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

TSSK2_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.054018 (rank : 187)
Query Neighborhood Hits	82	Target Neighborhood Hits	819	Shared Neighborhood Hits	60
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

TSSK4_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.054922 (rank : 172)
Query Neighborhood Hits	82	Target Neighborhood Hits	836	Shared Neighborhood Hits	59
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

TSSK6_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.050770 (rank : 306)
Query Neighborhood Hits	82	Target Neighborhood Hits	824	Shared Neighborhood Hits	59
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TSSK6_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.050612 (rank : 311)
Query Neighborhood Hits	82	Target Neighborhood Hits	824	Shared Neighborhood Hits	59
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TTK_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.052737 (rank : 233)
Query Neighborhood Hits	82	Target Neighborhood Hits	816	Shared Neighborhood Hits	59
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

ULK3_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.050290 (rank : 328)
Query Neighborhood Hits	82	Target Neighborhood Hits	830	Shared Neighborhood Hits	59
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.050458 (rank : 321)
Query Neighborhood Hits	82	Target Neighborhood Hits	872	Shared Neighborhood Hits	59
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK4_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.057899 (rank : 140)
Query Neighborhood Hits	82	Target Neighborhood Hits	793	Shared Neighborhood Hits	59
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

YSK4_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.051244 (rank : 291)
Query Neighborhood Hits	82	Target Neighborhood Hits	921	Shared Neighborhood Hits	59
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

Hits sorted by NC score

RIOK2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	82	Target Neighborhood Hits	82	Shared Neighborhood Hits	82
SwissProt Accessions	Q9CQS5, Q91XF3	Gene names	Riok2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).

RIOK2_HUMAN
NC score	0.959589 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	82	Target Neighborhood Hits	125	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BVS4, Q9NUT0	Gene names	RIOK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).

RIOK1_HUMAN
NC score	0.420852 (rank : 3)	θ value	3.29651e-10 (rank : 3)
Query Neighborhood Hits	82	Target Neighborhood Hits	86	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BRS2, Q8NDC8, Q96NV9	Gene names	RIOK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (RIO kinase 1).

RIOK3_MOUSE
NC score	0.346306 (rank : 4)	θ value	6.43352e-06 (rank : 4)
Query Neighborhood Hits	82	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBU3, Q8CIC1	Gene names	Riok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3).

RIOK3_HUMAN
NC score	0.337475 (rank : 5)	θ value	2.44474e-05 (rank : 5)
Query Neighborhood Hits	82	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	O14730, Q8IXN9	Gene names	RIOK3, SUDD
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog).

NRK_HUMAN
NC score	0.084005 (rank : 6)	θ value	0.0113563 (rank : 6)
Query Neighborhood Hits	82	Target Neighborhood Hits	931	Shared Neighborhood Hits	64
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

NRK_MOUSE
NC score	0.082169 (rank : 7)	θ value	0.0148317 (rank : 7)
Query Neighborhood Hits	82	Target Neighborhood Hits	899	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

KPCB_HUMAN
NC score	0.080168 (rank : 8)	θ value	0.21417 (rank : 10)
Query Neighborhood Hits	82	Target Neighborhood Hits	1121	Shared Neighborhood Hits	62
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
NC score	0.080156 (rank : 9)	θ value	0.21417 (rank : 11)
Query Neighborhood Hits	82	Target Neighborhood Hits	1117	Shared Neighborhood Hits	62
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCA_HUMAN
NC score	0.078723 (rank : 10)	θ value	0.279714 (rank : 12)
Query Neighborhood Hits	82	Target Neighborhood Hits	1070	Shared Neighborhood Hits	62
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

MASTL_HUMAN
NC score	0.077932 (rank : 11)	θ value	1.06291 (rank : 28)
Query Neighborhood Hits	82	Target Neighborhood Hits	894	Shared Neighborhood Hits	62
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

KPCE_HUMAN
NC score	0.077907 (rank : 12)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	82	Target Neighborhood Hits	906	Shared Neighborhood Hits	61
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_MOUSE
NC score	0.077799 (rank : 13)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	82	Target Neighborhood Hits	906	Shared Neighborhood Hits	62
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCG_HUMAN
NC score	0.077123 (rank : 14)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	82	Target Neighborhood Hits	1126	Shared Neighborhood Hits	62
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
NC score	0.077056 (rank : 15)	θ value	1.38821 (rank : 35)
Query Neighborhood Hits	82	Target Neighborhood Hits	1123	Shared Neighborhood Hits	62
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

MASTL_MOUSE
NC score	0.076918 (rank : 16)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	82	Target Neighborhood Hits	862	Shared Neighborhood Hits	62
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

KPCD_HUMAN
NC score	0.076471 (rank : 17)	θ value	0.62314 (rank : 19)
Query Neighborhood Hits	82	Target Neighborhood Hits	900	Shared Neighborhood Hits	61
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCA_MOUSE
NC score	0.076463 (rank : 18)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	82	Target Neighborhood Hits	1067	Shared Neighborhood Hits	62
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCT_HUMAN
NC score	0.076136 (rank : 19)	θ value	0.62314 (rank : 21)
Query Neighborhood Hits	82	Target Neighborhood Hits	897	Shared Neighborhood Hits	61
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCD_MOUSE
NC score	0.075981 (rank : 20)	θ value	0.62314 (rank : 20)
Query Neighborhood Hits	82	Target Neighborhood Hits	888	Shared Neighborhood Hits	61
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCT_MOUSE
NC score	0.074812 (rank : 21)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	82	Target Neighborhood Hits	895	Shared Neighborhood Hits	61
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

E2AK4_MOUSE
NC score	0.074583 (rank : 22)	θ value	0.47712 (rank : 16)
Query Neighborhood Hits	82	Target Neighborhood Hits	984	Shared Neighborhood Hits	62
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

E2AK4_HUMAN
NC score	0.073695 (rank : 23)	θ value	0.47712 (rank : 15)
Query Neighborhood Hits	82	Target Neighborhood Hits	1012	Shared Neighborhood Hits	62
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

KPCZ_MOUSE
NC score	0.071484 (rank : 24)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	82	Target Neighborhood Hits	882	Shared Neighborhood Hits	60
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_HUMAN
NC score	0.071431 (rank : 25)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	82	Target Neighborhood Hits	884	Shared Neighborhood Hits	60
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

LATS1_MOUSE
NC score	0.071394 (rank : 26)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	82	Target Neighborhood Hits	1027	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

KPCL_HUMAN
NC score	0.071363 (rank : 27)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	82	Target Neighborhood Hits	887	Shared Neighborhood Hits	59
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

LATS1_HUMAN
NC score	0.071096 (rank : 28)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	82	Target Neighborhood Hits	1057	Shared Neighborhood Hits	61
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

AKT2_MOUSE
NC score	0.070870 (rank : 29)	θ value	0.62314 (rank : 17)
Query Neighborhood Hits	82	Target Neighborhood Hits	875	Shared Neighborhood Hits	60
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

M4K3_HUMAN
NC score	0.070776 (rank : 30)	θ value	0.365318 (rank : 14)
Query Neighborhood Hits	82	Target Neighborhood Hits	857	Shared Neighborhood Hits	61
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

KPCL_MOUSE
NC score	0.070615 (rank : 31)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	82	Target Neighborhood Hits	891	Shared Neighborhood Hits	60
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

AKT2_HUMAN
NC score	0.069832 (rank : 32)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	82	Target Neighborhood Hits	878	Shared Neighborhood Hits	60
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT3_MOUSE
NC score	0.069758 (rank : 33)	θ value	2.36792 (rank : 45)
Query Neighborhood Hits	82	Target Neighborhood Hits	872	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

AKT3_HUMAN
NC score	0.069754 (rank : 34)	θ value	2.36792 (rank : 44)
Query Neighborhood Hits	82	Target Neighborhood Hits	872	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT1_MOUSE
NC score	0.069368 (rank : 35)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	82	Target Neighborhood Hits	878	Shared Neighborhood Hits	60
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

KPCI_HUMAN
NC score	0.069312 (rank : 36)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	82	Target Neighborhood Hits	885	Shared Neighborhood Hits	59
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
NC score	0.069276 (rank : 37)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	82	Target Neighborhood Hits	888	Shared Neighborhood Hits	59
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

AKT1_HUMAN
NC score	0.069202 (rank : 38)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	82	Target Neighborhood Hits	885	Shared Neighborhood Hits	60
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

KS6B2_MOUSE
NC score	0.069108 (rank : 39)	θ value	1.06291 (rank : 27)
Query Neighborhood Hits	82	Target Neighborhood Hits	871	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

MAST4_HUMAN
NC score	0.068415 (rank : 40)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	82	Target Neighborhood Hits	1804	Shared Neighborhood Hits	64
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

TYDP1_MOUSE
NC score	0.068238 (rank : 41)	θ value	0.0961366 (rank : 9)
Query Neighborhood Hits	82	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BJ37, Q8VE39	Gene names	Tdp1
Domain Architecture
Description	Tyrosyl-DNA phosphodiesterase 1 (EC 3.1.4.-) (Tyr-DNA phosphodiesterase 1).

MAST1_MOUSE
NC score	0.068108 (rank : 42)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	82	Target Neighborhood Hits	1123	Shared Neighborhood Hits	61
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_HUMAN
NC score	0.067957 (rank : 43)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	82	Target Neighborhood Hits	1146	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

LATS2_MOUSE
NC score	0.067732 (rank : 44)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	82	Target Neighborhood Hits	879	Shared Neighborhood Hits	60
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

MAST3_HUMAN
NC score	0.067731 (rank : 45)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	82	Target Neighborhood Hits	1128	Shared Neighborhood Hits	61
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

RPKL1_MOUSE
NC score	0.067594 (rank : 46)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	82	Target Neighborhood Hits	704	Shared Neighborhood Hits	58
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

LATS2_HUMAN
NC score	0.067337 (rank : 47)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	82	Target Neighborhood Hits	884	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

M4K2_MOUSE
NC score	0.066713 (rank : 48)	θ value	1.81305 (rank : 42)
Query Neighborhood Hits	82	Target Neighborhood Hits	843	Shared Neighborhood Hits	61
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

RPKL1_HUMAN
NC score	0.066215 (rank : 49)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	82	Target Neighborhood Hits	708	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

ST38L_MOUSE
NC score	0.065831 (rank : 50)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	82	Target Neighborhood Hits	821	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

SGK1_MOUSE
NC score	0.065618 (rank : 51)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	82	Target Neighborhood Hits	848	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

MAST2_HUMAN
NC score	0.065602 (rank : 52)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	82	Target Neighborhood Hits	1189	Shared Neighborhood Hits	61
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

STK38_MOUSE
NC score	0.065466 (rank : 53)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	82	Target Neighborhood Hits	838	Shared Neighborhood Hits	59
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_HUMAN
NC score	0.065457 (rank : 54)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	82	Target Neighborhood Hits	840	Shared Neighborhood Hits	59
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

DMPK_HUMAN
NC score	0.065423 (rank : 55)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	82	Target Neighborhood Hits	944	Shared Neighborhood Hits	59
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

SGK2_HUMAN
NC score	0.065412 (rank : 56)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	82	Target Neighborhood Hits	840	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

MAST2_MOUSE
NC score	0.065371 (rank : 57)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	82	Target Neighborhood Hits	1110	Shared Neighborhood Hits	60
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

ST38L_HUMAN
NC score	0.065358 (rank : 58)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	82	Target Neighborhood Hits	824	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

SGK1_HUMAN
NC score	0.065284 (rank : 59)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	82	Target Neighborhood Hits	848	Shared Neighborhood Hits	60
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK2_MOUSE
NC score	0.065167 (rank : 60)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	82	Target Neighborhood Hits	833	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

PKN1_MOUSE
NC score	0.065147 (rank : 61)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	82	Target Neighborhood Hits	888	Shared Neighborhood Hits	59
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

DMPK_MOUSE
NC score	0.065132 (rank : 62)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	82	Target Neighborhood Hits	908	Shared Neighborhood Hits	59
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

PKN1_HUMAN
NC score	0.065088 (rank : 63)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	82	Target Neighborhood Hits	886	Shared Neighborhood Hits	59
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

SGK3_MOUSE
NC score	0.065022 (rank : 64)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	82	Target Neighborhood Hits	882	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

SGK3_HUMAN
NC score	0.065021 (rank : 65)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	82	Target Neighborhood Hits	877	Shared Neighborhood Hits	59
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

KS6B2_HUMAN
NC score	0.064973 (rank : 66)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	82	Target Neighborhood Hits	858	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

PKN2_MOUSE
NC score	0.064821 (rank : 67)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	82	Target Neighborhood Hits	899	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

M4K5_MOUSE
NC score	0.064765 (rank : 68)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	82	Target Neighborhood Hits	839	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

PKN2_HUMAN
NC score	0.064726 (rank : 69)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	82	Target Neighborhood Hits	892	Shared Neighborhood Hits	59
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

M4K5_HUMAN
NC score	0.064488 (rank : 70)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	82	Target Neighborhood Hits	845	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

PKN3_HUMAN
NC score	0.064165 (rank : 71)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	82	Target Neighborhood Hits	893	Shared Neighborhood Hits	59
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

M4K2_HUMAN
NC score	0.064139 (rank : 72)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	82	Target Neighborhood Hits	850	Shared Neighborhood Hits	61
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

KS6B1_HUMAN
NC score	0.063996 (rank : 73)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	82	Target Neighborhood Hits	850	Shared Neighborhood Hits	59
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
NC score	0.063996 (rank : 74)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	82	Target Neighborhood Hits	849	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

PKN3_MOUSE
NC score	0.063929 (rank : 75)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	82	Target Neighborhood Hits	1009	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

KKCC2_MOUSE
NC score	0.063865 (rank : 76)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	82	Target Neighborhood Hits	855	Shared Neighborhood Hits	61
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_HUMAN
NC score	0.063807 (rank : 77)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	82	Target Neighborhood Hits	852	Shared Neighborhood Hits	61
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

F5006_MOUSE
NC score	0.063435 (rank : 78)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	82	Target Neighborhood Hits	793	Shared Neighborhood Hits	60
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

ST32B_HUMAN
NC score	0.063397 (rank : 79)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	82	Target Neighborhood Hits	830	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

RK_HUMAN
NC score	0.063181 (rank : 80)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	82	Target Neighborhood Hits	835	Shared Neighborhood Hits	59
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ST32B_MOUSE
NC score	0.063000 (rank : 81)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	82	Target Neighborhood Hits	828	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

ARBK2_HUMAN
NC score	0.062884 (rank : 82)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	82	Target Neighborhood Hits	849	Shared Neighborhood Hits	59
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

KS6C1_HUMAN
NC score	0.062811 (rank : 83)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	82	Target Neighborhood Hits	682	Shared Neighborhood Hits	57
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

ARBK1_MOUSE
NC score	0.062749 (rank : 84)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	82	Target Neighborhood Hits	849	Shared Neighborhood Hits	59
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

KS6A5_MOUSE
NC score	0.062596 (rank : 85)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	82	Target Neighborhood Hits	854	Shared Neighborhood Hits	60
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

ST32A_HUMAN
NC score	0.062588 (rank : 86)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	82	Target Neighborhood Hits	834	Shared Neighborhood Hits	60
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

KS6C1_MOUSE
NC score	0.062471 (rank : 87)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	82	Target Neighborhood Hits	700	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

ARBK1_HUMAN
NC score	0.062440 (rank : 88)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	82	Target Neighborhood Hits	859	Shared Neighborhood Hits	59
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

RK_MOUSE
NC score	0.062351 (rank : 89)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	82	Target Neighborhood Hits	829	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

GRK4_HUMAN
NC score	0.062346 (rank : 90)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	82	Target Neighborhood Hits	822	Shared Neighborhood Hits	59
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

F5006_HUMAN
NC score	0.062336 (rank : 91)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	82	Target Neighborhood Hits	794	Shared Neighborhood Hits	60
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

TSSK4_MOUSE
NC score	0.062026 (rank : 92)	θ value	0.813845 (rank : 24)
Query Neighborhood Hits	82	Target Neighborhood Hits	840	Shared Neighborhood Hits	61
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

KAPCB_MOUSE
NC score	0.062020 (rank : 93)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	82	Target Neighborhood Hits	836	Shared Neighborhood Hits	59
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KS6A4_HUMAN
NC score	0.061834 (rank : 94)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	82	Target Neighborhood Hits	868	Shared Neighborhood Hits	60
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

KAPCB_HUMAN
NC score	0.061791 (rank : 95)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	82	Target Neighborhood Hits	837	Shared Neighborhood Hits	59
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCA_MOUSE
NC score	0.061688 (rank : 96)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	82	Target Neighborhood Hits	836	Shared Neighborhood Hits	59
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KS6A4_MOUSE
NC score	0.061637 (rank : 97)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	82	Target Neighborhood Hits	866	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

GRK4_MOUSE
NC score	0.061538 (rank : 98)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	82	Target Neighborhood Hits	808	Shared Neighborhood Hits	59
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

PRKX_HUMAN
NC score	0.061532 (rank : 99)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	82	Target Neighborhood Hits	847	Shared Neighborhood Hits	59
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

KAPCA_HUMAN
NC score	0.061514 (rank : 100)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	82	Target Neighborhood Hits	838	Shared Neighborhood Hits	59
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

TNIK_HUMAN
NC score	0.061458 (rank : 101)	θ value	0.0961366 (rank : 8)
Query Neighborhood Hits	82	Target Neighborhood Hits	1570	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

HUNK_MOUSE
NC score	0.061417 (rank : 102)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	82	Target Neighborhood Hits	874	Shared Neighborhood Hits	62
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

GRK5_HUMAN
NC score	0.061386 (rank : 103)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	82	Target Neighborhood Hits	819	Shared Neighborhood Hits	59
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

PAK7_MOUSE
NC score	0.061332 (rank : 104)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	82	Target Neighborhood Hits	875	Shared Neighborhood Hits	61
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PRKX_MOUSE
NC score	0.061304 (rank : 105)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	82	Target Neighborhood Hits	846	Shared Neighborhood Hits	59
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

GRK5_MOUSE
NC score	0.061260 (rank : 106)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	82	Target Neighborhood Hits	823	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK7_HUMAN
NC score	0.061233 (rank : 107)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	82	Target Neighborhood Hits	820	Shared Neighborhood Hits	59
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

ST32A_MOUSE
NC score	0.061228 (rank : 108)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	82	Target Neighborhood Hits	833	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

PDPK1_MOUSE
NC score	0.061134 (rank : 109)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	82	Target Neighborhood Hits	852	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PDPK1_HUMAN
NC score	0.061123 (rank : 110)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	82	Target Neighborhood Hits	851	Shared Neighborhood Hits	61
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

HUNK_HUMAN
NC score	0.060961 (rank : 111)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	82	Target Neighborhood Hits	884	Shared Neighborhood Hits	62
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

KGP1A_HUMAN
NC score	0.060915 (rank : 112)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	82	Target Neighborhood Hits	901	Shared Neighborhood Hits	59
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

CHK1_MOUSE
NC score	0.060898 (rank : 113)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	82	Target Neighborhood Hits	839	Shared Neighborhood Hits	61
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

KGP1B_MOUSE
NC score	0.060872 (rank : 114)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	82	Target Neighborhood Hits	922	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_HUMAN
NC score	0.060864 (rank : 115)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	82	Target Neighborhood Hits	921	Shared Neighborhood Hits	59
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

ST32C_HUMAN
NC score	0.060689 (rank : 116)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	82	Target Neighborhood Hits	832	Shared Neighborhood Hits	60
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

ST32C_MOUSE
NC score	0.060604 (rank : 117)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	82	Target Neighborhood Hits	824	Shared Neighborhood Hits	59
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

MRCKG_HUMAN
NC score	0.060590 (rank : 118)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	82	Target Neighborhood Hits	1519	Shared Neighborhood Hits	59
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRCKG_MOUSE
NC score	0.060568 (rank : 119)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	82	Target Neighborhood Hits	1466	Shared Neighborhood Hits	59
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

PAK7_HUMAN
NC score	0.060563 (rank : 120)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	82	Target Neighborhood Hits	875	Shared Neighborhood Hits	60
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

KAPCG_HUMAN
NC score	0.060548 (rank : 121)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	82	Target Neighborhood Hits	845	Shared Neighborhood Hits	59
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

PRKY_HUMAN
NC score	0.060477 (rank : 122)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	82	Target Neighborhood Hits	844	Shared Neighborhood Hits	59
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

GRK6_MOUSE
NC score	0.060407 (rank : 123)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	82	Target Neighborhood Hits	820	Shared Neighborhood Hits	59
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK6_HUMAN
NC score	0.060165 (rank : 124)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	82	Target Neighborhood Hits	823	Shared Neighborhood Hits	59
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

KS6A5_HUMAN
NC score	0.060087 (rank : 125)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	82	Target Neighborhood Hits	855	Shared Neighborhood Hits	60
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

KGP2_MOUSE
NC score	0.058674 (rank : 126)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	82	Target Neighborhood Hits	1029	Shared Neighborhood Hits	59
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KS6A2_HUMAN
NC score	0.058547 (rank : 127)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	82	Target Neighborhood Hits	857	Shared Neighborhood Hits	59
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A1_MOUSE
NC score	0.058454 (rank : 128)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	82	Target Neighborhood Hits	850	Shared Neighborhood Hits	59
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KGP2_HUMAN
NC score	0.058392 (rank : 129)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	82	Target Neighborhood Hits	1023	Shared Neighborhood Hits	59
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

ROCK2_HUMAN
NC score	0.058345 (rank : 130)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	82	Target Neighborhood Hits	2073	Shared Neighborhood Hits	60
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

KS6A1_HUMAN
NC score	0.058275 (rank : 131)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	82	Target Neighborhood Hits	854	Shared Neighborhood Hits	59
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_MOUSE
NC score	0.058263 (rank : 132)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	82	Target Neighborhood Hits	858	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KS6A3_MOUSE
NC score	0.058249 (rank : 133)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	82	Target Neighborhood Hits	860	Shared Neighborhood Hits	59
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_HUMAN
NC score	0.058246 (rank : 134)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	82	Target Neighborhood Hits	859	Shared Neighborhood Hits	59
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A6_HUMAN
NC score	0.058167 (rank : 135)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	82	Target Neighborhood Hits	853	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

PAK4_MOUSE
NC score	0.058059 (rank : 136)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	82	Target Neighborhood Hits	1098	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

KKCC1_HUMAN
NC score	0.058054 (rank : 137)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	82	Target Neighborhood Hits	858	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

ROCK2_MOUSE
NC score	0.058035 (rank : 138)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	82	Target Neighborhood Hits	2072	Shared Neighborhood Hits	60
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

KKCC1_MOUSE
NC score	0.057971 (rank : 139)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	82	Target Neighborhood Hits	866	Shared Neighborhood Hits	60
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

ULK4_MOUSE
NC score	0.057899 (rank : 140)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	82	Target Neighborhood Hits	793	Shared Neighborhood Hits	59
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

PAK4_HUMAN
NC score	0.057583 (rank : 141)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	82	Target Neighborhood Hits	924	Shared Neighborhood Hits	59
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

M3K14_HUMAN
NC score	0.057425 (rank : 142)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	82	Target Neighborhood Hits	887	Shared Neighborhood Hits	61
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

M4K1_MOUSE
NC score	0.057237 (rank : 143)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	82	Target Neighborhood Hits	858	Shared Neighborhood Hits	59
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

PAK6_HUMAN
NC score	0.057221 (rank : 144)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	82	Target Neighborhood Hits	915	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

M4K1_HUMAN
NC score	0.056695 (rank : 145)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	82	Target Neighborhood Hits	884	Shared Neighborhood Hits	59
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

CP053_HUMAN
NC score	0.056679 (rank : 146)	θ value	0.62314 (rank : 18)
Query Neighborhood Hits	82	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BTK6	Gene names	C16orf53
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf53.

ROCK1_HUMAN
NC score	0.056160 (rank : 147)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	82	Target Neighborhood Hits	2000	Shared Neighborhood Hits	59
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

MRCKA_HUMAN
NC score	0.056089 (rank : 148)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	82	Target Neighborhood Hits	1999	Shared Neighborhood Hits	60
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

M4K4_MOUSE
NC score	0.056069 (rank : 149)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	82	Target Neighborhood Hits	1560	Shared Neighborhood Hits	62
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MINK1_MOUSE
NC score	0.056027 (rank : 150)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	82	Target Neighborhood Hits	1451	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_HUMAN
NC score	0.056003 (rank : 151)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	82	Target Neighborhood Hits	1477	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

STK40_MOUSE
NC score	0.055922 (rank : 152)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	82	Target Neighborhood Hits	751	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

M4K4_HUMAN
NC score	0.055801 (rank : 153)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	82	Target Neighborhood Hits	1589	Shared Neighborhood Hits	61
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

STK40_HUMAN
NC score	0.055777 (rank : 154)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	82	Target Neighborhood Hits	751	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK39_MOUSE
NC score	0.055707 (rank : 155)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	82	Target Neighborhood Hits	915	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

MST4_MOUSE
NC score	0.055641 (rank : 156)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	82	Target Neighborhood Hits	860	Shared Neighborhood Hits	60
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MST4_HUMAN
NC score	0.055632 (rank : 157)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	82	Target Neighborhood Hits	852	Shared Neighborhood Hits	60
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

CHK1_HUMAN
NC score	0.055526 (rank : 158)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	82	Target Neighborhood Hits	843	Shared Neighborhood Hits	60
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

MP2K7_HUMAN
NC score	0.055525 (rank : 159)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	82	Target Neighborhood Hits	833	Shared Neighborhood Hits	60
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

STK25_MOUSE
NC score	0.055524 (rank : 160)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	82	Target Neighborhood Hits	851	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_HUMAN
NC score	0.055470 (rank : 161)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	82	Target Neighborhood Hits	853	Shared Neighborhood Hits	59
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

AURKB_HUMAN
NC score	0.055284 (rank : 162)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	82	Target Neighborhood Hits	847	Shared Neighborhood Hits	59
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

AURKB_MOUSE
NC score	0.055254 (rank : 163)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	82	Target Neighborhood Hits	858	Shared Neighborhood Hits	59
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

MRCKB_MOUSE
NC score	0.055174 (rank : 164)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	82	Target Neighborhood Hits	2180	Shared Neighborhood Hits	61
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PAK1_MOUSE
NC score	0.055154 (rank : 165)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	82	Target Neighborhood Hits	878	Shared Neighborhood Hits	59
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK3_MOUSE
NC score	0.055107 (rank : 166)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	82	Target Neighborhood Hits	874	Shared Neighborhood Hits	60
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

TRIB3_MOUSE
NC score	0.055080 (rank : 167)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	82	Target Neighborhood Hits	578	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

PAK3_HUMAN
NC score	0.055042 (rank : 168)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	82	Target Neighborhood Hits	887	Shared Neighborhood Hits	60
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PLK1_HUMAN
NC score	0.054977 (rank : 169)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	82	Target Neighborhood Hits	849	Shared Neighborhood Hits	59
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

ROCK1_MOUSE
NC score	0.054968 (rank : 170)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	82	Target Neighborhood Hits	2126	Shared Neighborhood Hits	59
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

PAK1_HUMAN
NC score	0.054944 (rank : 171)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	82	Target Neighborhood Hits	873	Shared Neighborhood Hits	59
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

TSSK4_HUMAN
NC score	0.054922 (rank : 172)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	82	Target Neighborhood Hits	836	Shared Neighborhood Hits	59
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

PLK1_MOUSE
NC score	0.054878 (rank : 173)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	82	Target Neighborhood Hits	849	Shared Neighborhood Hits	59
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

M3K14_MOUSE
NC score	0.054859 (rank : 174)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	82	Target Neighborhood Hits	889	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

STK24_MOUSE
NC score	0.054794 (rank : 175)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	82	Target Neighborhood Hits	856	Shared Neighborhood Hits	59
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK24_HUMAN
NC score	0.054772 (rank : 176)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	82	Target Neighborhood Hits	853	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

AURKC_MOUSE
NC score	0.054707 (rank : 177)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	82	Target Neighborhood Hits	844	Shared Neighborhood Hits	59
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

CTRO_HUMAN
NC score	0.054583 (rank : 178)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	82	Target Neighborhood Hits	2092	Shared Neighborhood Hits	61
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

PAK2_MOUSE
NC score	0.054572 (rank : 179)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	82	Target Neighborhood Hits	858	Shared Neighborhood Hits	59
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK2_HUMAN
NC score	0.054568 (rank : 180)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	82	Target Neighborhood Hits	862	Shared Neighborhood Hits	59
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

AURKC_HUMAN
NC score	0.054394 (rank : 181)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	82	Target Neighborhood Hits	847	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

MRCKB_HUMAN
NC score	0.054379 (rank : 182)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	82	Target Neighborhood Hits	2239	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

OXSR1_MOUSE
NC score	0.054128 (rank : 183)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	82	Target Neighborhood Hits	865	Shared Neighborhood Hits	59
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PMYT1_HUMAN
NC score	0.054123 (rank : 184)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	82	Target Neighborhood Hits	814	Shared Neighborhood Hits	59
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

TSSK1_HUMAN
NC score	0.054123 (rank : 185)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	82	Target Neighborhood Hits	840	Shared Neighborhood Hits	60
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

M3K8_MOUSE
NC score	0.054106 (rank : 186)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	82	Target Neighborhood Hits	815	Shared Neighborhood Hits	58
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

TSSK2_MOUSE
NC score	0.054018 (rank : 187)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	82	Target Neighborhood Hits	819	Shared Neighborhood Hits	60
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

TRIB3_HUMAN
NC score	0.053999 (rank : 188)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	82	Target Neighborhood Hits	519	Shared Neighborhood Hits	53
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

AAPK1_MOUSE
NC score	0.053970 (rank : 189)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	82	Target Neighborhood Hits	843	Shared Neighborhood Hits	59
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK2_HUMAN
NC score	0.053932 (rank : 190)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	82	Target Neighborhood Hits	843	Shared Neighborhood Hits	59
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

OXSR1_HUMAN
NC score	0.053908 (rank : 191)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	82	Target Neighborhood Hits	874	Shared Neighborhood Hits	59
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

AAPK1_HUMAN
NC score	0.053846 (rank : 192)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	82	Target Neighborhood Hits	842	Shared Neighborhood Hits	59
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

STK39_HUMAN
NC score	0.053796 (rank : 193)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	82	Target Neighborhood Hits	882	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

TSSK2_HUMAN
NC score	0.053763 (rank : 194)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	82	Target Neighborhood Hits	826	Shared Neighborhood Hits	60
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

STK3_HUMAN
NC score	0.053741 (rank : 195)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	82	Target Neighborhood Hits	861	Shared Neighborhood Hits	59
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

NUAK2_MOUSE
NC score	0.053724 (rank : 196)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	82	Target Neighborhood Hits	878	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

M3K8_HUMAN
NC score	0.053714 (rank : 197)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	82	Target Neighborhood Hits	807	Shared Neighborhood Hits	57
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

NIM1_MOUSE
NC score	0.053697 (rank : 198)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	82	Target Neighborhood Hits	850	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

STK6_MOUSE
NC score	0.053641 (rank : 199)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	82	Target Neighborhood Hits	886	Shared Neighborhood Hits	59
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

NEK3_MOUSE
NC score	0.053621 (rank : 200)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	82	Target Neighborhood Hits	854	Shared Neighborhood Hits	59
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

HTSF1_MOUSE
NC score	0.053566 (rank : 201)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	82	Target Neighborhood Hits	425	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGC0, Q1WWK0, Q9CT41, Q9DAU3	Gene names	Htatsf1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 homolog.

TRIB2_HUMAN
NC score	0.053519 (rank : 202)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	82	Target Neighborhood Hits	657	Shared Neighborhood Hits	56
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

STK11_HUMAN
NC score	0.053491 (rank : 203)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	82	Target Neighborhood Hits	831	Shared Neighborhood Hits	59
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

KCC1D_MOUSE
NC score	0.053471 (rank : 204)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	82	Target Neighborhood Hits	847	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

PLK4_HUMAN
NC score	0.053469 (rank : 205)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	82	Target Neighborhood Hits	884	Shared Neighborhood Hits	60
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
NC score	0.053463 (rank : 206)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	82	Target Neighborhood Hits	879	Shared Neighborhood Hits	60
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

STK6_HUMAN
NC score	0.053460 (rank : 207)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	82	Target Neighborhood Hits	916	Shared Neighborhood Hits	59
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

KCC1D_HUMAN
NC score	0.053459 (rank : 208)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	82	Target Neighborhood Hits	846	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

TTK_MOUSE
NC score	0.053438 (rank : 209)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	82	Target Neighborhood Hits	803	Shared Neighborhood Hits	61
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

STK3_MOUSE
NC score	0.053432 (rank : 210)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	82	Target Neighborhood Hits	869	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

PLK2_HUMAN
NC score	0.053430 (rank : 211)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	82	Target Neighborhood Hits	854	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

NUAK2_HUMAN
NC score	0.053426 (rank : 212)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	82	Target Neighborhood Hits	874	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

M3K2_HUMAN
NC score	0.053423 (rank : 213)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	82	Target Neighborhood Hits	849	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

TRIB2_MOUSE
NC score	0.053416 (rank : 214)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	82	Target Neighborhood Hits	653	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

PLK2_MOUSE
NC score	0.053382 (rank : 215)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	82	Target Neighborhood Hits	849	Shared Neighborhood Hits	59
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

MP2K5_HUMAN
NC score	0.053370 (rank : 216)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	82	Target Neighborhood Hits	837	Shared Neighborhood Hits	59
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

NIM1_HUMAN
NC score	0.053363 (rank : 217)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	82	Target Neighborhood Hits	850	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PMYT1_MOUSE
NC score	0.053308 (rank : 218)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	82	Target Neighborhood Hits	910	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

TRIB1_HUMAN
NC score	0.053229 (rank : 219)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	82	Target Neighborhood Hits	598	Shared Neighborhood Hits	53
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

MKNK1_MOUSE
NC score	0.053103 (rank : 220)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	82	Target Neighborhood Hits	811	Shared Neighborhood Hits	60
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

M3K2_MOUSE
NC score	0.053048 (rank : 221)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	82	Target Neighborhood Hits	846	Shared Neighborhood Hits	59
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K6_HUMAN
NC score	0.053044 (rank : 222)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	82	Target Neighborhood Hits	889	Shared Neighborhood Hits	60
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

STK4_HUMAN
NC score	0.053014 (rank : 223)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	82	Target Neighborhood Hits	870	Shared Neighborhood Hits	59
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
NC score	0.052989 (rank : 224)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	82	Target Neighborhood Hits	873	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

PINK1_MOUSE
NC score	0.052948 (rank : 225)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	82	Target Neighborhood Hits	726	Shared Neighborhood Hits	59
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

MP2K1_MOUSE
NC score	0.052923 (rank : 226)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	82	Target Neighborhood Hits	826	Shared Neighborhood Hits	59
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_HUMAN
NC score	0.052866 (rank : 227)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	82	Target Neighborhood Hits	826	Shared Neighborhood Hits	59
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

NEK3_HUMAN
NC score	0.052865 (rank : 228)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	82	Target Neighborhood Hits	865	Shared Neighborhood Hits	59
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

MELK_MOUSE
NC score	0.052832 (rank : 229)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	82	Target Neighborhood Hits	860	Shared Neighborhood Hits	59
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

MP2K5_MOUSE
NC score	0.052820 (rank : 230)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	82	Target Neighborhood Hits	840	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

PLK3_HUMAN
NC score	0.052756 (rank : 231)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	82	Target Neighborhood Hits	865	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PDK1L_HUMAN
NC score	0.052741 (rank : 232)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	82	Target Neighborhood Hits	821	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

TTK_HUMAN
NC score	0.052737 (rank : 233)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	82	Target Neighborhood Hits	816	Shared Neighborhood Hits	59
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

MP2K3_MOUSE
NC score	0.052731 (rank : 234)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	82	Target Neighborhood Hits	826	Shared Neighborhood Hits	59
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

PLK3_MOUSE
NC score	0.052707 (rank : 235)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	82	Target Neighborhood Hits	863	Shared Neighborhood Hits	59
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PINK1_HUMAN
NC score	0.052666 (rank : 236)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	82	Target Neighborhood Hits	741	Shared Neighborhood Hits	59
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PDK1L_MOUSE
NC score	0.052636 (rank : 237)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	82	Target Neighborhood Hits	821	Shared Neighborhood Hits	60
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

TRIB1_MOUSE
NC score	0.052615 (rank : 238)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	82	Target Neighborhood Hits	593	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

PASK_MOUSE
NC score	0.052605 (rank : 239)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	82	Target Neighborhood Hits	867	Shared Neighborhood Hits	59
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

M3K3_MOUSE
NC score	0.052603 (rank : 240)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	82	Target Neighborhood Hits	876	Shared Neighborhood Hits	59
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

KPSH1_MOUSE
NC score	0.052550 (rank : 241)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	82	Target Neighborhood Hits	839	Shared Neighborhood Hits	60
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

M3K3_HUMAN
NC score	0.052547 (rank : 242)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	82	Target Neighborhood Hits	885	Shared Neighborhood Hits	59
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

KCC1G_MOUSE
NC score	0.052536 (rank : 243)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	82	Target Neighborhood Hits	851	Shared Neighborhood Hits	60
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

SBK1_HUMAN
NC score	0.052498 (rank : 244)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	82	Target Neighborhood Hits	828	Shared Neighborhood Hits	59
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

KCC1G_HUMAN
NC score	0.052474 (rank : 245)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	82	Target Neighborhood Hits	850	Shared Neighborhood Hits	60
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

STK33_HUMAN
NC score	0.052471 (rank : 246)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	82	Target Neighborhood Hits	879	Shared Neighborhood Hits	60
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

ST17A_HUMAN
NC score	0.052470 (rank : 247)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	82	Target Neighborhood Hits	843	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

KPSH1_HUMAN
NC score	0.052468 (rank : 248)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	82	Target Neighborhood Hits	842	Shared Neighborhood Hits	60
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

CTRO_MOUSE
NC score	0.052452 (rank : 249)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	82	Target Neighborhood Hits	2344	Shared Neighborhood Hits	61
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

SLK_MOUSE
NC score	0.052439 (rank : 250)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	82	Target Neighborhood Hits	1798	Shared Neighborhood Hits	63
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

MELK_HUMAN
NC score	0.052375 (rank : 251)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	82	Target Neighborhood Hits	847	Shared Neighborhood Hits	59
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

M3K15_HUMAN
NC score	0.052356 (rank : 252)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	82	Target Neighborhood Hits	914	Shared Neighborhood Hits	59
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

NUAK1_HUMAN
NC score	0.052354 (rank : 253)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	82	Target Neighborhood Hits	874	Shared Neighborhood Hits	59
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
NC score	0.052343 (rank : 254)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	82	Target Neighborhood Hits	881	Shared Neighborhood Hits	59
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

KCC1B_HUMAN
NC score	0.052342 (rank : 255)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	82	Target Neighborhood Hits	842	Shared Neighborhood Hits	60
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KPSH2_HUMAN
NC score	0.052324 (rank : 256)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	82	Target Neighborhood Hits	822	Shared Neighborhood Hits	60
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KCC1A_HUMAN
NC score	0.052272 (rank : 257)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	82	Target Neighborhood Hits	846	Shared Neighborhood Hits	59
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
NC score	0.052248 (rank : 258)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	82	Target Neighborhood Hits	845	Shared Neighborhood Hits	59
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

SBK1_MOUSE
NC score	0.052234 (rank : 259)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	82	Target Neighborhood Hits	824	Shared Neighborhood Hits	59
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

CHK2_HUMAN
NC score	0.052213 (rank : 260)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	82	Target Neighborhood Hits	859	Shared Neighborhood Hits	59
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

SLK_HUMAN
NC score	0.052211 (rank : 261)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	82	Target Neighborhood Hits	1775	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

KCC1B_MOUSE
NC score	0.052194 (rank : 262)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	82	Target Neighborhood Hits	842	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

MP2K2_MOUSE
NC score	0.052087 (rank : 263)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	82	Target Neighborhood Hits	828	Shared Neighborhood Hits	59
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_HUMAN
NC score	0.052062 (rank : 264)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	82	Target Neighborhood Hits	825	Shared Neighborhood Hits	59
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MARK2_MOUSE
NC score	0.052062 (rank : 265)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	82	Target Neighborhood Hits	1018	Shared Neighborhood Hits	59
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

M3K5_MOUSE
NC score	0.052021 (rank : 266)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	82	Target Neighborhood Hits	867	Shared Neighborhood Hits	59
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

MARK2_HUMAN
NC score	0.051963 (rank : 267)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	82	Target Neighborhood Hits	1056	Shared Neighborhood Hits	60
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

M3K5_HUMAN
NC score	0.051962 (rank : 268)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	82	Target Neighborhood Hits	868	Shared Neighborhood Hits	59
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

MP2K2_HUMAN
NC score	0.051958 (rank : 269)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	82	Target Neighborhood Hits	830	Shared Neighborhood Hits	59
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MKNK1_HUMAN
NC score	0.051941 (rank : 270)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	82	Target Neighborhood Hits	701	Shared Neighborhood Hits	59
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MARK1_MOUSE
NC score	0.051895 (rank : 271)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	82	Target Neighborhood Hits	886	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MKNK2_HUMAN
NC score	0.051840 (rank : 272)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	82	Target Neighborhood Hits	821	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

KCC4_MOUSE
NC score	0.051806 (rank : 273)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	82	Target Neighborhood Hits	899	Shared Neighborhood Hits	63
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

BRSK1_HUMAN
NC score	0.051787 (rank : 274)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	82	Target Neighborhood Hits	942	Shared Neighborhood Hits	59
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

MARK1_HUMAN
NC score	0.051742 (rank : 275)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	82	Target Neighborhood Hits	887	Shared Neighborhood Hits	59
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

ST17B_HUMAN
NC score	0.051741 (rank : 276)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	82	Target Neighborhood Hits	833	Shared Neighborhood Hits	60
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

MARK3_MOUSE
NC score	0.051726 (rank : 277)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	82	Target Neighborhood Hits	919	Shared Neighborhood Hits	59
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

CHK2_MOUSE
NC score	0.051723 (rank : 278)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	82	Target Neighborhood Hits	860	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

E2AK2_MOUSE
NC score	0.051699 (rank : 279)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	82	Target Neighborhood Hits	864	Shared Neighborhood Hits	60
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

STK36_HUMAN
NC score	0.051681 (rank : 280)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	82	Target Neighborhood Hits	896	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

TSSK1_MOUSE
NC score	0.051669 (rank : 281)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	82	Target Neighborhood Hits	835	Shared Neighborhood Hits	60
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

NEK2_MOUSE
NC score	0.051569 (rank : 282)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	82	Target Neighborhood Hits	876	Shared Neighborhood Hits	59
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

MKNK2_MOUSE
NC score	0.051524 (rank : 283)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	82	Target Neighborhood Hits	819	Shared Neighborhood Hits	58
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MARK4_HUMAN
NC score	0.051519 (rank : 284)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	82	Target Neighborhood Hits	886	Shared Neighborhood Hits	59
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
NC score	0.051510 (rank : 285)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	82	Target Neighborhood Hits	898	Shared Neighborhood Hits	59
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

BRSK2_HUMAN
NC score	0.051431 (rank : 286)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	82	Target Neighborhood Hits	897	Shared Neighborhood Hits	59
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

STK10_HUMAN
NC score	0.051364 (rank : 287)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	82	Target Neighborhood Hits	1921	Shared Neighborhood Hits	60
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

KCC4_HUMAN
NC score	0.051313 (rank : 288)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	82	Target Neighborhood Hits	841	Shared Neighborhood Hits	60
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

M3K1_MOUSE
NC score	0.051290 (rank : 289)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	82	Target Neighborhood Hits	952	Shared Neighborhood Hits	59
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

MARK3_HUMAN
NC score	0.051280 (rank : 290)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	82	Target Neighborhood Hits	893	Shared Neighborhood Hits	59
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

YSK4_HUMAN
NC score	0.051244 (rank : 291)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	82	Target Neighborhood Hits	921	Shared Neighborhood Hits	59
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

PASK_HUMAN
NC score	0.051213 (rank : 292)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	82	Target Neighborhood Hits	857	Shared Neighborhood Hits	59
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

STK35_HUMAN
NC score	0.051206 (rank : 293)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	82	Target Neighborhood Hits	825	Shared Neighborhood Hits	60
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

PHKG1_MOUSE
NC score	0.051163 (rank : 294)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	82	Target Neighborhood Hits	840	Shared Neighborhood Hits	60
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

ST17B_MOUSE
NC score	0.051118 (rank : 295)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	82	Target Neighborhood Hits	838	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

NEK4_HUMAN
NC score	0.051074 (rank : 296)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	82	Target Neighborhood Hits	883	Shared Neighborhood Hits	59
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
NC score	0.051028 (rank : 297)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	82	Target Neighborhood Hits	899	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

M3K4_HUMAN
NC score	0.050927 (rank : 298)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	82	Target Neighborhood Hits	911	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

PTMA_HUMAN
NC score	0.050914 (rank : 299)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	82	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	P06454, Q15249, Q15592	Gene names	PTMA, TMSA
Domain Architecture	No domain graphic available
Description	Prothymosin alpha [Contains: Thymosin alpha-1].

RIPK1_MOUSE
NC score	0.050891 (rank : 300)	θ value	2.36792 (rank : 46)
Query Neighborhood Hits	82	Target Neighborhood Hits	874	Shared Neighborhood Hits	61
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

PHKG2_HUMAN
NC score	0.050873 (rank : 301)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	82	Target Neighborhood Hits	839	Shared Neighborhood Hits	59
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

PHKG1_HUMAN
NC score	0.050861 (rank : 302)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	82	Target Neighborhood Hits	838	Shared Neighborhood Hits	59
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG2_MOUSE
NC score	0.050821 (rank : 303)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	82	Target Neighborhood Hits	841	Shared Neighborhood Hits	59
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

NEK1_HUMAN
NC score	0.050813 (rank : 304)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	82	Target Neighborhood Hits	1129	Shared Neighborhood Hits	61
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

M3K4_MOUSE
NC score	0.050812 (rank : 305)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	82	Target Neighborhood Hits	924	Shared Neighborhood Hits	59
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

TSSK6_HUMAN
NC score	0.050770 (rank : 306)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	82	Target Neighborhood Hits	824	Shared Neighborhood Hits	59
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

DCAK3_HUMAN
NC score	0.050743 (rank : 307)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	82	Target Neighborhood Hits	888	Shared Neighborhood Hits	60
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

MAPK5_MOUSE
NC score	0.050712 (rank : 308)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	82	Target Neighborhood Hits	799	Shared Neighborhood Hits	57
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

PIM2_MOUSE
NC score	0.050701 (rank : 309)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	82	Target Neighborhood Hits	809	Shared Neighborhood Hits	59
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

DCAK3_MOUSE
NC score	0.050680 (rank : 310)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	82	Target Neighborhood Hits	922	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

TSSK6_MOUSE
NC score	0.050612 (rank : 311)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	82	Target Neighborhood Hits	824	Shared Neighborhood Hits	59
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

PIM3_MOUSE
NC score	0.050581 (rank : 312)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	82	Target Neighborhood Hits	783	Shared Neighborhood Hits	59
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

NEK2_HUMAN
NC score	0.050567 (rank : 313)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	82	Target Neighborhood Hits	908	Shared Neighborhood Hits	59
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

MP2K4_MOUSE
NC score	0.050548 (rank : 314)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	82	Target Neighborhood Hits	833	Shared Neighborhood Hits	59
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MAPK3_HUMAN
NC score	0.050547 (rank : 315)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	82	Target Neighborhood Hits	807	Shared Neighborhood Hits	57
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

E2AK1_MOUSE
NC score	0.050528 (rank : 316)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	82	Target Neighborhood Hits	821	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

MAPK3_MOUSE
NC score	0.050519 (rank : 317)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	82	Target Neighborhood Hits	811	Shared Neighborhood Hits	57
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MP2K4_HUMAN
NC score	0.050513 (rank : 318)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	82	Target Neighborhood Hits	832	Shared Neighborhood Hits	59
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

RIPK5_MOUSE
NC score	0.050505 (rank : 319)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	82	Target Neighborhood Hits	874	Shared Neighborhood Hits	59
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

MAPK5_HUMAN
NC score	0.050486 (rank : 320)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	82	Target Neighborhood Hits	795	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

ULK3_MOUSE
NC score	0.050458 (rank : 321)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	82	Target Neighborhood Hits	872	Shared Neighborhood Hits	59
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

RIPK5_HUMAN
NC score	0.050444 (rank : 322)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	82	Target Neighborhood Hits	864	Shared Neighborhood Hits	59
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

STK36_MOUSE
NC score	0.050418 (rank : 323)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	82	Target Neighborhood Hits	877	Shared Neighborhood Hits	60
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

NEK1_MOUSE
NC score	0.050402 (rank : 324)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	82	Target Neighborhood Hits	1311	Shared Neighborhood Hits	63
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK11_HUMAN
NC score	0.050395 (rank : 325)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	82	Target Neighborhood Hits	1043	Shared Neighborhood Hits	60
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PIM3_HUMAN
NC score	0.050360 (rank : 326)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	82	Target Neighborhood Hits	789	Shared Neighborhood Hits	59
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

KCC2A_MOUSE
NC score	0.050349 (rank : 327)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	82	Target Neighborhood Hits	829	Shared Neighborhood Hits	59
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

ULK3_HUMAN
NC score	0.050290 (rank : 328)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	82	Target Neighborhood Hits	830	Shared Neighborhood Hits	59
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

SN1L1_HUMAN
NC score	0.050245 (rank : 329)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	82	Target Neighborhood Hits	911	Shared Neighborhood Hits	60
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

DAPK2_MOUSE
NC score	0.050239 (rank : 330)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	82	Target Neighborhood Hits	834	Shared Neighborhood Hits	60
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

NEK11_MOUSE
NC score	0.050134 (rank : 331)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	82	Target Neighborhood Hits	875	Shared Neighborhood Hits	59
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

K0999_HUMAN
NC score	0.050069 (rank : 332)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	82	Target Neighborhood Hits	899	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

TAOK3_HUMAN
NC score	0.050047 (rank : 333)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	82	Target Neighborhood Hits	1494	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

SN1L2_MOUSE
NC score	0.050003 (rank : 334)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	82	Target Neighborhood Hits	944	Shared Neighborhood Hits	59
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

RIPK1_HUMAN
NC score	0.049929 (rank : 335)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	82	Target Neighborhood Hits	891	Shared Neighborhood Hits	60
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

EXO1_HUMAN
NC score	0.043008 (rank : 336)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	82	Target Neighborhood Hits	82	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UQ84, O60545, O75214, O75466, Q5T396, Q96IJ1, Q9UG38, Q9UNW0	Gene names	EXO1, EXOI, HEX1
Domain Architecture	No domain graphic available
Description	Exonuclease 1 (EC 3.1.-.-) (hExo1) (Exonuclease I) (hExoI).

ERCC5_MOUSE
NC score	0.042148 (rank : 337)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	82	Target Neighborhood Hits	206	Shared Neighborhood Hits	7
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

TNI3K_MOUSE
NC score	0.041842 (rank : 338)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	82	Target Neighborhood Hits	1079	Shared Neighborhood Hits	61
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_HUMAN
NC score	0.041128 (rank : 339)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	82	Target Neighborhood Hits	1084	Shared Neighborhood Hits	61
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

AFF1_MOUSE
NC score	0.039633 (rank : 340)	θ value	0.365318 (rank : 13)
Query Neighborhood Hits	82	Target Neighborhood Hits	351	Shared Neighborhood Hits	7
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

IF39_MOUSE
NC score	0.036691 (rank : 341)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	82	Target Neighborhood Hits	206	Shared Neighborhood Hits	6
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

PRPK_MOUSE
NC score	0.030704 (rank : 342)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	82	Target Neighborhood Hits	139	Shared Neighborhood Hits	18
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PELO_MOUSE
NC score	0.022949 (rank : 343)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	82	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q80X73, Q6PG91, Q91UZ2	Gene names	Pelo
Domain Architecture	No domain graphic available
Description	Protein pelota homolog.

CO5_MOUSE
NC score	0.021899 (rank : 344)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	82	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	P06684	Gene names	C5, Hc
Domain Architecture
Description	Complement C5 precursor (Hemolytic complement) [Contains: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain].

IKAP_HUMAN
NC score	0.019620 (rank : 345)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	82	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	O95163, Q9H327, Q9UG87	Gene names	IKBKAP, IKAP
Domain Architecture
Description	IkappaB kinase complex-associated protein (IKK complex-associated protein) (p150).

SYT10_HUMAN
NC score	0.018332 (rank : 346)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	82	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

IP3KB_HUMAN
NC score	0.017225 (rank : 347)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	82	Target Neighborhood Hits	124	Shared Neighborhood Hits	4
SwissProt Accessions	P27987, Q5VWL9, Q5VWM0, Q96BZ2, Q96JS1, Q9UH47	Gene names	ITPKB
Domain Architecture
Description	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase B) (IP3K B) (IP3 3-kinase B) (IP3K-B).

TF3B_MOUSE
NC score	0.017092 (rank : 348)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	82	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CFK2	Gene names	Brf1
Domain Architecture	No domain graphic available
Description	Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B- related factor 1) (BRF-1).

IWS1_HUMAN
NC score	0.015353 (rank : 349)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	82	Target Neighborhood Hits	1241	Shared Neighborhood Hits	13
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

GASP1_HUMAN
NC score	0.013857 (rank : 350)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	82	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q5JY77, O43168, Q96LA1	Gene names	GPRASP1, GASP, KIAA0443
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor-associated sorting protein 1 (GASP-1).

PI4KA_HUMAN
NC score	0.012933 (rank : 351)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	82	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

LEO1_MOUSE
NC score	0.012001 (rank : 352)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	82	Target Neighborhood Hits	946	Shared Neighborhood Hits	8
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

NMD3B_HUMAN
NC score	0.009147 (rank : 353)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	82	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	O60391, Q5EAK7, Q7RTW9	Gene names	GRIN3B
Domain Architecture	No domain graphic available
Description	Glutamate [NMDA] receptor subunit 3B precursor (N-methyl-D-aspartate receptor subtype NR3B) (NR3B) (NMDAR3B).