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Network neighborhood for query Sequence : SYYC_HUMAN

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SYYC_HUMAN
SwissProt Accessions	P54577, O43276, Q53EN1	Gene names	YARS
Domain Architecture
Description	Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1) (Tyrosyl--tRNA ligase) (TyrRS).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SYYC_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P54577, O43276, Q53EN1	Gene names	YARS
Domain Architecture
Description	Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1) (Tyrosyl--tRNA ligase) (TyrRS).

SYYC_MOUSE
θ value	0 (rank : 2)	NC score	0.998071 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	15
SwissProt Accessions	Q91WQ3, Q3TEC8, Q3U9A1, Q3UTA7, Q8BVT2, Q8C183	Gene names	Yars
Domain Architecture	No domain graphic available
Description	Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1) (Tyrosyl--tRNA ligase) (TyrRS).

MCA1_MOUSE
θ value	5.95217e-44 (rank : 3)	NC score	0.827497 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	P31230, Q60659	Gene names	Scye1, Emap2
Domain Architecture
Description	Multisynthetase complex auxiliary component p43 [Contains: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)].

MCA1_HUMAN
θ value	4.2656e-42 (rank : 4)	NC score	0.826558 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q12904, Q6FG28, Q96CQ9	Gene names	SCYE1, EMAP2
Domain Architecture
Description	Multisynthetase complex auxiliary component p43 [Contains: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)].

SYW_HUMAN
θ value	0.0148317 (rank : 5)	NC score	0.156160 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	P23381, P78535, Q9UDL3	Gene names	WARS, WRS
Domain Architecture
Description	Tryptophanyl-tRNA synthetase (EC 6.1.1.2) (Tryptophan--tRNA ligase) (TrpRS) (IFP53) (hWRS).

SYW_MOUSE
θ value	0.0431538 (rank : 6)	NC score	0.142266 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	P32921, Q80ZY4, Q99J58, Q9DC65	Gene names	Wars, Wrs
Domain Architecture
Description	Tryptophanyl-tRNA synthetase (EC 6.1.1.2) (Tryptophan--tRNA ligase) (TrpRS).

TITIN_HUMAN
θ value	0.21417 (rank : 7)	NC score	0.012622 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	2923	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

BCAS1_HUMAN
θ value	0.279714 (rank : 8)	NC score	0.070970 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	133	Shared Neighborhood Hits	3
SwissProt Accessions	O75363, Q68CZ3	Gene names	BCAS1, AIBC1, NABC1
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 1 (Novel amplified in breast cancer 1) (Amplified and overexpressed in breast cancer).

ATR_HUMAN
θ value	0.62314 (rank : 9)	NC score	0.037522 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

AL1A1_HUMAN
θ value	1.81305 (rank : 10)	NC score	0.024620 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	P00352, O00768	Gene names	ALDH1A1, ALDC, ALDH1
Domain Architecture
Description	Retinal dehydrogenase 1 (EC 1.2.1.36) (RalDH1) (RALDH 1) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (ALHDII) (ALDH-E1).

AL1A1_MOUSE
θ value	1.81305 (rank : 11)	NC score	0.024767 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	P24549, Q7TQJ0, Q811J0	Gene names	Aldh1a1, Ahd-2, Ahd2, Aldh1
Domain Architecture
Description	Retinal dehydrogenase 1 (EC 1.2.1.36) (RalDH1) (RALDH 1) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (ALHDII) (ALDH-E1).

AP2A1_HUMAN
θ value	1.81305 (rank : 12)	NC score	0.029240 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

GRAC_MOUSE
θ value	5.27518 (rank : 13)	NC score	0.007312 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	177	Shared Neighborhood Hits	3
SwissProt Accessions	P08882, Q61389	Gene names	Gzmc, Ctla-5, Ctla5
Domain Architecture
Description	Granzyme C precursor (EC 3.4.21.-) (Cytotoxic cell protease 2) (CCP2) (B10).

CNGA3_MOUSE
θ value	6.88961 (rank : 14)	NC score	0.016697 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

MAML1_HUMAN
θ value	6.88961 (rank : 15)	NC score	0.013262 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	228	Shared Neighborhood Hits	3
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

AP2A1_MOUSE
θ value	8.99809 (rank : 16)	NC score	0.016686 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	57	Shared Neighborhood Hits	3
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

BSN_HUMAN
θ value	8.99809 (rank : 17)	NC score	0.005844 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	1537	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

LRC40_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.005654 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	311	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CRC8, Q78WQ9, Q8BS83	Gene names	Lrrc40
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 40.

Hits sorted by NC score

SYYC_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P54577, O43276, Q53EN1	Gene names	YARS
Domain Architecture
Description	Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1) (Tyrosyl--tRNA ligase) (TyrRS).

SYYC_MOUSE
NC score	0.998071 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	15
SwissProt Accessions	Q91WQ3, Q3TEC8, Q3U9A1, Q3UTA7, Q8BVT2, Q8C183	Gene names	Yars
Domain Architecture	No domain graphic available
Description	Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1) (Tyrosyl--tRNA ligase) (TyrRS).

MCA1_MOUSE
NC score	0.827497 (rank : 3)	θ value	5.95217e-44 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	P31230, Q60659	Gene names	Scye1, Emap2
Domain Architecture
Description	Multisynthetase complex auxiliary component p43 [Contains: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)].

MCA1_HUMAN
NC score	0.826558 (rank : 4)	θ value	4.2656e-42 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q12904, Q6FG28, Q96CQ9	Gene names	SCYE1, EMAP2
Domain Architecture
Description	Multisynthetase complex auxiliary component p43 [Contains: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)].

SYW_HUMAN
NC score	0.156160 (rank : 5)	θ value	0.0148317 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	P23381, P78535, Q9UDL3	Gene names	WARS, WRS
Domain Architecture
Description	Tryptophanyl-tRNA synthetase (EC 6.1.1.2) (Tryptophan--tRNA ligase) (TrpRS) (IFP53) (hWRS).

SYW_MOUSE
NC score	0.142266 (rank : 6)	θ value	0.0431538 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	P32921, Q80ZY4, Q99J58, Q9DC65	Gene names	Wars, Wrs
Domain Architecture
Description	Tryptophanyl-tRNA synthetase (EC 6.1.1.2) (Tryptophan--tRNA ligase) (TrpRS).

BCAS1_HUMAN
NC score	0.070970 (rank : 7)	θ value	0.279714 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	133	Shared Neighborhood Hits	3
SwissProt Accessions	O75363, Q68CZ3	Gene names	BCAS1, AIBC1, NABC1
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 1 (Novel amplified in breast cancer 1) (Amplified and overexpressed in breast cancer).

ATR_HUMAN
NC score	0.037522 (rank : 8)	θ value	0.62314 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

AP2A1_HUMAN
NC score	0.029240 (rank : 9)	θ value	1.81305 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AL1A1_MOUSE
NC score	0.024767 (rank : 10)	θ value	1.81305 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	P24549, Q7TQJ0, Q811J0	Gene names	Aldh1a1, Ahd-2, Ahd2, Aldh1
Domain Architecture
Description	Retinal dehydrogenase 1 (EC 1.2.1.36) (RalDH1) (RALDH 1) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (ALHDII) (ALDH-E1).

AL1A1_HUMAN
NC score	0.024620 (rank : 11)	θ value	1.81305 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	P00352, O00768	Gene names	ALDH1A1, ALDC, ALDH1
Domain Architecture
Description	Retinal dehydrogenase 1 (EC 1.2.1.36) (RalDH1) (RALDH 1) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (ALHDII) (ALDH-E1).

CNGA3_MOUSE
NC score	0.016697 (rank : 12)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

AP2A1_MOUSE
NC score	0.016686 (rank : 13)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	57	Shared Neighborhood Hits	3
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

MAML1_HUMAN
NC score	0.013262 (rank : 14)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	228	Shared Neighborhood Hits	3
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

TITIN_HUMAN
NC score	0.012622 (rank : 15)	θ value	0.21417 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	2923	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

GRAC_MOUSE
NC score	0.007312 (rank : 16)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	177	Shared Neighborhood Hits	3
SwissProt Accessions	P08882, Q61389	Gene names	Gzmc, Ctla-5, Ctla5
Domain Architecture
Description	Granzyme C precursor (EC 3.4.21.-) (Cytotoxic cell protease 2) (CCP2) (B10).

BSN_HUMAN
NC score	0.005844 (rank : 17)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	1537	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

LRC40_MOUSE
NC score	0.005654 (rank : 18)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	311	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CRC8, Q78WQ9, Q8BS83	Gene names	Lrrc40
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 40.