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Network neighborhood for query Sequence : FBX24_MOUSE

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FBX24_MOUSE
SwissProt Accessions	Q9D417	Gene names	Fbxo24, Fbx24
Domain Architecture	No domain graphic available
Description	F-box only protein 24.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FBX24_HUMAN
θ value	0 (rank : 1)	NC score	0.988069 (rank : 2)
Query Neighborhood Hits	59	Target Neighborhood Hits	57	Shared Neighborhood Hits	47
SwissProt Accessions	O75426, Q9H0G1	Gene names	FBXO24, FBX24
Domain Architecture
Description	F-box only protein 24.

FBX24_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	59
SwissProt Accessions	Q9D417	Gene names	Fbxo24, Fbx24
Domain Architecture	No domain graphic available
Description	F-box only protein 24.

RCC2_HUMAN
θ value	0.000121331 (rank : 3)	NC score	0.351307 (rank : 3)
Query Neighborhood Hits	59	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC2_MOUSE
θ value	0.00020696 (rank : 4)	NC score	0.348059 (rank : 4)
Query Neighborhood Hits	59	Target Neighborhood Hits	37	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

RCBT2_HUMAN
θ value	0.00134147 (rank : 5)	NC score	0.283481 (rank : 10)
Query Neighborhood Hits	59	Target Neighborhood Hits	158	Shared Neighborhood Hits	28
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

RCBT2_MOUSE
θ value	0.00175202 (rank : 6)	NC score	0.279851 (rank : 12)
Query Neighborhood Hits	59	Target Neighborhood Hits	156	Shared Neighborhood Hits	28
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

WBS16_HUMAN
θ value	0.00175202 (rank : 7)	NC score	0.313932 (rank : 5)
Query Neighborhood Hits	59	Target Neighborhood Hits	29	Shared Neighborhood Hits	28
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

FBXW7_HUMAN
θ value	0.00228821 (rank : 8)	NC score	0.069027 (rank : 36)
Query Neighborhood Hits	59	Target Neighborhood Hits	433	Shared Neighborhood Hits	17
SwissProt Accessions	Q969H0, Q96A16, Q96LE0, Q96RI2, Q9NUX6	Gene names	FBXW7, FBW7, FBX30, SEL10
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBX30) (hCdc4) (Archipelago homolog) (hAgo) (SEL-10).

FBXW7_MOUSE
θ value	0.00228821 (rank : 9)	NC score	0.069336 (rank : 35)
Query Neighborhood Hits	59	Target Neighborhood Hits	365	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VBV4, Q8CCS5, Q8VHP4	Gene names	Fbxw7, Fbw7, Fbwd6, Fbxw6
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10).

MYCB2_HUMAN
θ value	0.00509761 (rank : 10)	NC score	0.215860 (rank : 18)
Query Neighborhood Hits	59	Target Neighborhood Hits	390	Shared Neighborhood Hits	28
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

RPGR_MOUSE
θ value	0.00869519 (rank : 11)	NC score	0.287446 (rank : 9)
Query Neighborhood Hits	59	Target Neighborhood Hits	281	Shared Neighborhood Hits	28
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

RCBT1_MOUSE
θ value	0.0113563 (rank : 12)	NC score	0.262801 (rank : 13)
Query Neighborhood Hits	59	Target Neighborhood Hits	157	Shared Neighborhood Hits	28
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

RPGR_HUMAN
θ value	0.0113563 (rank : 13)	NC score	0.281580 (rank : 11)
Query Neighborhood Hits	59	Target Neighborhood Hits	279	Shared Neighborhood Hits	28
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

FBX33_HUMAN
θ value	0.0148317 (rank : 14)	NC score	0.199929 (rank : 24)
Query Neighborhood Hits	59	Target Neighborhood Hits	42	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z6M2, Q6PIR2, Q86TR2, Q86YE0	Gene names	FBXO33, FBX33
Domain Architecture	No domain graphic available
Description	F-box only protein 33.

HERC2_MOUSE
θ value	0.0252991 (rank : 15)	NC score	0.209722 (rank : 20)
Query Neighborhood Hits	59	Target Neighborhood Hits	167	Shared Neighborhood Hits	30
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC3_HUMAN
θ value	0.0252991 (rank : 16)	NC score	0.207970 (rank : 22)
Query Neighborhood Hits	59	Target Neighborhood Hits	62	Shared Neighborhood Hits	29
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC2_HUMAN
θ value	0.0330416 (rank : 17)	NC score	0.209229 (rank : 21)
Query Neighborhood Hits	59	Target Neighborhood Hits	163	Shared Neighborhood Hits	29
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

RCC1_MOUSE
θ value	0.0330416 (rank : 18)	NC score	0.298817 (rank : 7)
Query Neighborhood Hits	59	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

RCBT1_HUMAN
θ value	0.0431538 (rank : 19)	NC score	0.258188 (rank : 16)
Query Neighborhood Hits	59	Target Neighborhood Hits	158	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

ALS2_MOUSE
θ value	0.0563607 (rank : 20)	NC score	0.220335 (rank : 17)
Query Neighborhood Hits	59	Target Neighborhood Hits	111	Shared Neighborhood Hits	28
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

MYCB2_MOUSE
θ value	0.0563607 (rank : 21)	NC score	0.205758 (rank : 23)
Query Neighborhood Hits	59	Target Neighborhood Hits	307	Shared Neighborhood Hits	28
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

WBS16_MOUSE
θ value	0.0736092 (rank : 22)	NC score	0.300127 (rank : 6)
Query Neighborhood Hits	59	Target Neighborhood Hits	31	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

FBX46_HUMAN
θ value	0.0961366 (rank : 23)	NC score	0.103964 (rank : 31)
Query Neighborhood Hits	59	Target Neighborhood Hits	68	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PJ61	Gene names	FBXO46, FBX46, FBXO34L
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

FBX46_MOUSE
θ value	0.0961366 (rank : 24)	NC score	0.102286 (rank : 32)
Query Neighborhood Hits	59	Target Neighborhood Hits	139	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BG80	Gene names	Fbxo46, Fbx46, Fbxo34l
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

FBX4_HUMAN
θ value	0.0961366 (rank : 25)	NC score	0.112762 (rank : 29)
Query Neighborhood Hits	59	Target Neighborhood Hits	33	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UKT5, Q68CU8, Q86VT8, Q9UK98	Gene names	FBXO4, FBX4
Domain Architecture
Description	F-box only protein 4.

FBX36_HUMAN
θ value	0.125558 (rank : 26)	NC score	0.118606 (rank : 27)
Query Neighborhood Hits	59	Target Neighborhood Hits	30	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NEA4, Q8WWD4	Gene names	FBXO36, FBX36
Domain Architecture	No domain graphic available
Description	F-box only protein 36.

ALS2_HUMAN
θ value	0.21417 (rank : 27)	NC score	0.210135 (rank : 19)
Query Neighborhood Hits	59	Target Neighborhood Hits	121	Shared Neighborhood Hits	29
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

NEK8_HUMAN
θ value	0.21417 (rank : 28)	NC score	0.064922 (rank : 39)
Query Neighborhood Hits	59	Target Neighborhood Hits	872	Shared Neighborhood Hits	30
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

PHLD1_HUMAN
θ value	0.21417 (rank : 29)	NC score	0.054486 (rank : 42)
Query Neighborhood Hits	59	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	P80108, Q15128	Gene names	GPLD1, PIGPLD1
Domain Architecture
Description	Phosphatidylinositol-glycan-specific phospholipase D 1 precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein phospholipase D) (Glycosyl- phosphatidylinositol-specific phospholipase D).

FXL12_HUMAN
θ value	0.279714 (rank : 30)	NC score	0.114531 (rank : 28)
Query Neighborhood Hits	59	Target Neighborhood Hits	86	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NXK8, Q9H5K4	Gene names	FBXL12, FBL12
Domain Architecture
Description	F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12).

NEK9_HUMAN
θ value	0.279714 (rank : 31)	NC score	0.067450 (rank : 38)
Query Neighborhood Hits	59	Target Neighborhood Hits	900	Shared Neighborhood Hits	30
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	0.279714 (rank : 32)	NC score	0.068353 (rank : 37)
Query Neighborhood Hits	59	Target Neighborhood Hits	890	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

HERC5_HUMAN
θ value	0.47712 (rank : 33)	NC score	0.192202 (rank : 25)
Query Neighborhood Hits	59	Target Neighborhood Hits	66	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

RCC1_HUMAN
θ value	0.47712 (rank : 34)	NC score	0.287611 (rank : 8)
Query Neighborhood Hits	59	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

FBX31_HUMAN
θ value	0.62314 (rank : 35)	NC score	0.161054 (rank : 26)
Query Neighborhood Hits	59	Target Neighborhood Hits	55	Shared Neighborhood Hits	14
SwissProt Accessions	Q5XUX0, Q96D73, Q9UFV4	Gene names	FBXO31, FBX14, FBX31
Domain Architecture	No domain graphic available
Description	F-box only protein 31.

FXL12_MOUSE
θ value	0.62314 (rank : 36)	NC score	0.104087 (rank : 30)
Query Neighborhood Hits	59	Target Neighborhood Hits	79	Shared Neighborhood Hits	18
SwissProt Accessions	Q9EPX5, Q3UVH7, Q8CDX0, Q9CY04, Q9QZN5	Gene names	Fbxl12, Fbl12
Domain Architecture
Description	F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12).

PHLD2_HUMAN
θ value	0.813845 (rank : 37)	NC score	0.049752 (rank : 44)
Query Neighborhood Hits	59	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q15127	Gene names	GPLD2, PIGPLD2
Domain Architecture
Description	Phosphatidylinositol-glycan-specific phospholipase D 2 precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein phospholipase D) (Glycosyl- phosphatidylinositol-specific phospholipase D).

SRGEF_HUMAN
θ value	0.813845 (rank : 38)	NC score	0.262754 (rank : 14)
Query Neighborhood Hits	59	Target Neighborhood Hits	33	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

TSP3_HUMAN
θ value	1.06291 (rank : 39)	NC score	0.017612 (rank : 55)
Query Neighborhood Hits	59	Target Neighborhood Hits	250	Shared Neighborhood Hits	3
SwissProt Accessions	P49746, Q8WV34	Gene names	THBS3, TSP3
Domain Architecture
Description	Thrombospondin-3 precursor.

SRGEF_MOUSE
θ value	1.38821 (rank : 40)	NC score	0.262206 (rank : 15)
Query Neighborhood Hits	59	Target Neighborhood Hits	37	Shared Neighborhood Hits	28
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

FBX18_MOUSE
θ value	1.81305 (rank : 41)	NC score	0.050620 (rank : 43)
Query Neighborhood Hits	59	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K2I9, Q8C444, Q99KS0, Q9CTC6, Q9QZG7	Gene names	Fbxo18, Fbh1, Fbx18
Domain Architecture
Description	F-box only protein 18 (EC 3.6.1.-) (F-box DNA helicase 1).

FBX36_MOUSE
θ value	1.81305 (rank : 42)	NC score	0.093376 (rank : 33)
Query Neighborhood Hits	59	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	Q9CQ24	Gene names	Fbxo36
Domain Architecture	No domain graphic available
Description	F-box only protein 36.

HTF4_HUMAN
θ value	1.81305 (rank : 43)	NC score	0.060187 (rank : 41)
Query Neighborhood Hits	59	Target Neighborhood Hits	152	Shared Neighborhood Hits	6
SwissProt Accessions	Q99081	Gene names	TCF12, HEB, HTF4
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4).

HTF4_MOUSE
θ value	1.81305 (rank : 44)	NC score	0.045140 (rank : 48)
Query Neighborhood Hits	59	Target Neighborhood Hits	153	Shared Neighborhood Hits	5
SwissProt Accessions	Q61286	Gene names	Tcf12, Alf1, Meb
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4) (Class A helix-loop-helix transcription factor ME1).

NEK8_MOUSE
θ value	2.36792 (rank : 45)	NC score	0.060390 (rank : 40)
Query Neighborhood Hits	59	Target Neighborhood Hits	872	Shared Neighborhood Hits	30
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NIN_MOUSE
θ value	2.36792 (rank : 46)	NC score	0.006615 (rank : 58)
Query Neighborhood Hits	59	Target Neighborhood Hits	1376	Shared Neighborhood Hits	3
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

FBX4_MOUSE
θ value	3.0926 (rank : 47)	NC score	0.085442 (rank : 34)
Query Neighborhood Hits	59	Target Neighborhood Hits	36	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CHQ0, Q99JG8	Gene names	Fbxo4, Fbx4
Domain Architecture	No domain graphic available
Description	F-box only protein 4.

RIPK2_MOUSE
θ value	3.0926 (rank : 48)	NC score	0.009167 (rank : 57)
Query Neighborhood Hits	59	Target Neighborhood Hits	776	Shared Neighborhood Hits	7
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

FBX18_HUMAN
θ value	4.03905 (rank : 49)	NC score	0.044986 (rank : 49)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFZ0, Q7Z4Q6, Q7Z4R0, Q8N1P5, Q8N586, Q96E82, Q96K67, Q96SW7, Q9UFB2	Gene names	FBXO18, FBH1, FBX18
Domain Architecture
Description	F-box only protein 18 (EC 3.6.1.-) (F-box DNA helicase 1).

FBX32_MOUSE
θ value	4.03905 (rank : 50)	NC score	0.049398 (rank : 45)
Query Neighborhood Hits	59	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9CPU7	Gene names	Fbxo32
Domain Architecture	No domain graphic available
Description	F-box only protein 32 (Muscle atrophy F-box protein) (MAFbx) (Atrogin- 1).

ITF2_HUMAN
θ value	4.03905 (rank : 51)	NC score	0.040920 (rank : 51)
Query Neighborhood Hits	59	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

ITF2_MOUSE
θ value	4.03905 (rank : 52)	NC score	0.040964 (rank : 50)
Query Neighborhood Hits	59	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

FXL14_HUMAN
θ value	5.27518 (rank : 53)	NC score	0.046228 (rank : 47)
Query Neighborhood Hits	59	Target Neighborhood Hits	71	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N1E6	Gene names	FBXL14, FBL14
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14).

FXL14_MOUSE
θ value	5.27518 (rank : 54)	NC score	0.046271 (rank : 46)
Query Neighborhood Hits	59	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BID8, Q3U2Q9, Q8R5H7, Q8VDT7, Q922N5	Gene names	Fbxl14, Fbl14, Ppa
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14).

HECD1_HUMAN
θ value	6.88961 (rank : 55)	NC score	0.026731 (rank : 53)
Query Neighborhood Hits	59	Target Neighborhood Hits	371	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

TITIN_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.004663 (rank : 59)
Query Neighborhood Hits	59	Target Neighborhood Hits	2923	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

FBX32_HUMAN
θ value	8.99809 (rank : 57)	NC score	0.037774 (rank : 52)
Query Neighborhood Hits	59	Target Neighborhood Hits	14	Shared Neighborhood Hits	6
SwissProt Accessions	Q969P5	Gene names	FBXO32
Domain Architecture	No domain graphic available
Description	F-box only protein 32 (Muscle atrophy F-box protein) (MAFbx) (Atrogin- 1).

FBXL3_MOUSE
θ value	8.99809 (rank : 58)	NC score	0.021477 (rank : 54)
Query Neighborhood Hits	59	Target Neighborhood Hits	37	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C4V4, Q80V32, Q8K1W0, Q9QXW1	Gene names	Fbxl3, Fbl3a, Fbxl3a
Domain Architecture
Description	F-box/LRR-repeat protein 3 (F-box/LRR-repeat protein 3A) (F-box and leucine-rich repeat protein 3A).

NHLC1_MOUSE
θ value	8.99809 (rank : 59)	NC score	0.012705 (rank : 56)
Query Neighborhood Hits	59	Target Neighborhood Hits	103	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BR37	Gene names	Nhlrc1, Epm2b
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

Hits sorted by NC score

FBX24_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	59
SwissProt Accessions	Q9D417	Gene names	Fbxo24, Fbx24
Domain Architecture	No domain graphic available
Description	F-box only protein 24.

FBX24_HUMAN
NC score	0.988069 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	59	Target Neighborhood Hits	57	Shared Neighborhood Hits	47
SwissProt Accessions	O75426, Q9H0G1	Gene names	FBXO24, FBX24
Domain Architecture
Description	F-box only protein 24.

RCC2_HUMAN
NC score	0.351307 (rank : 3)	θ value	0.000121331 (rank : 3)
Query Neighborhood Hits	59	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC2_MOUSE
NC score	0.348059 (rank : 4)	θ value	0.00020696 (rank : 4)
Query Neighborhood Hits	59	Target Neighborhood Hits	37	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

WBS16_HUMAN
NC score	0.313932 (rank : 5)	θ value	0.00175202 (rank : 7)
Query Neighborhood Hits	59	Target Neighborhood Hits	29	Shared Neighborhood Hits	28
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

WBS16_MOUSE
NC score	0.300127 (rank : 6)	θ value	0.0736092 (rank : 22)
Query Neighborhood Hits	59	Target Neighborhood Hits	31	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

RCC1_MOUSE
NC score	0.298817 (rank : 7)	θ value	0.0330416 (rank : 18)
Query Neighborhood Hits	59	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

RCC1_HUMAN
NC score	0.287611 (rank : 8)	θ value	0.47712 (rank : 34)
Query Neighborhood Hits	59	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RPGR_MOUSE
NC score	0.287446 (rank : 9)	θ value	0.00869519 (rank : 11)
Query Neighborhood Hits	59	Target Neighborhood Hits	281	Shared Neighborhood Hits	28
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

RCBT2_HUMAN
NC score	0.283481 (rank : 10)	θ value	0.00134147 (rank : 5)
Query Neighborhood Hits	59	Target Neighborhood Hits	158	Shared Neighborhood Hits	28
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

RPGR_HUMAN
NC score	0.281580 (rank : 11)	θ value	0.0113563 (rank : 13)
Query Neighborhood Hits	59	Target Neighborhood Hits	279	Shared Neighborhood Hits	28
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RCBT2_MOUSE
NC score	0.279851 (rank : 12)	θ value	0.00175202 (rank : 6)
Query Neighborhood Hits	59	Target Neighborhood Hits	156	Shared Neighborhood Hits	28
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RCBT1_MOUSE
NC score	0.262801 (rank : 13)	θ value	0.0113563 (rank : 12)
Query Neighborhood Hits	59	Target Neighborhood Hits	157	Shared Neighborhood Hits	28
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

SRGEF_HUMAN
NC score	0.262754 (rank : 14)	θ value	0.813845 (rank : 38)
Query Neighborhood Hits	59	Target Neighborhood Hits	33	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SRGEF_MOUSE
NC score	0.262206 (rank : 15)	θ value	1.38821 (rank : 40)
Query Neighborhood Hits	59	Target Neighborhood Hits	37	Shared Neighborhood Hits	28
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

RCBT1_HUMAN
NC score	0.258188 (rank : 16)	θ value	0.0431538 (rank : 19)
Query Neighborhood Hits	59	Target Neighborhood Hits	158	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

ALS2_MOUSE
NC score	0.220335 (rank : 17)	θ value	0.0563607 (rank : 20)
Query Neighborhood Hits	59	Target Neighborhood Hits	111	Shared Neighborhood Hits	28
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

MYCB2_HUMAN
NC score	0.215860 (rank : 18)	θ value	0.00509761 (rank : 10)
Query Neighborhood Hits	59	Target Neighborhood Hits	390	Shared Neighborhood Hits	28
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

ALS2_HUMAN
NC score	0.210135 (rank : 19)	θ value	0.21417 (rank : 27)
Query Neighborhood Hits	59	Target Neighborhood Hits	121	Shared Neighborhood Hits	29
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

HERC2_MOUSE
NC score	0.209722 (rank : 20)	θ value	0.0252991 (rank : 15)
Query Neighborhood Hits	59	Target Neighborhood Hits	167	Shared Neighborhood Hits	30
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
NC score	0.209229 (rank : 21)	θ value	0.0330416 (rank : 17)
Query Neighborhood Hits	59	Target Neighborhood Hits	163	Shared Neighborhood Hits	29
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC3_HUMAN
NC score	0.207970 (rank : 22)	θ value	0.0252991 (rank : 16)
Query Neighborhood Hits	59	Target Neighborhood Hits	62	Shared Neighborhood Hits	29
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

MYCB2_MOUSE
NC score	0.205758 (rank : 23)	θ value	0.0563607 (rank : 21)
Query Neighborhood Hits	59	Target Neighborhood Hits	307	Shared Neighborhood Hits	28
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

FBX33_HUMAN
NC score	0.199929 (rank : 24)	θ value	0.0148317 (rank : 14)
Query Neighborhood Hits	59	Target Neighborhood Hits	42	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z6M2, Q6PIR2, Q86TR2, Q86YE0	Gene names	FBXO33, FBX33
Domain Architecture	No domain graphic available
Description	F-box only protein 33.

HERC5_HUMAN
NC score	0.192202 (rank : 25)	θ value	0.47712 (rank : 33)
Query Neighborhood Hits	59	Target Neighborhood Hits	66	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

FBX31_HUMAN
NC score	0.161054 (rank : 26)	θ value	0.62314 (rank : 35)
Query Neighborhood Hits	59	Target Neighborhood Hits	55	Shared Neighborhood Hits	14
SwissProt Accessions	Q5XUX0, Q96D73, Q9UFV4	Gene names	FBXO31, FBX14, FBX31
Domain Architecture	No domain graphic available
Description	F-box only protein 31.

FBX36_HUMAN
NC score	0.118606 (rank : 27)	θ value	0.125558 (rank : 26)
Query Neighborhood Hits	59	Target Neighborhood Hits	30	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NEA4, Q8WWD4	Gene names	FBXO36, FBX36
Domain Architecture	No domain graphic available
Description	F-box only protein 36.

FXL12_HUMAN
NC score	0.114531 (rank : 28)	θ value	0.279714 (rank : 30)
Query Neighborhood Hits	59	Target Neighborhood Hits	86	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NXK8, Q9H5K4	Gene names	FBXL12, FBL12
Domain Architecture
Description	F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12).

FBX4_HUMAN
NC score	0.112762 (rank : 29)	θ value	0.0961366 (rank : 25)
Query Neighborhood Hits	59	Target Neighborhood Hits	33	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UKT5, Q68CU8, Q86VT8, Q9UK98	Gene names	FBXO4, FBX4
Domain Architecture
Description	F-box only protein 4.

FXL12_MOUSE
NC score	0.104087 (rank : 30)	θ value	0.62314 (rank : 36)
Query Neighborhood Hits	59	Target Neighborhood Hits	79	Shared Neighborhood Hits	18
SwissProt Accessions	Q9EPX5, Q3UVH7, Q8CDX0, Q9CY04, Q9QZN5	Gene names	Fbxl12, Fbl12
Domain Architecture
Description	F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12).

FBX46_HUMAN
NC score	0.103964 (rank : 31)	θ value	0.0961366 (rank : 23)
Query Neighborhood Hits	59	Target Neighborhood Hits	68	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PJ61	Gene names	FBXO46, FBX46, FBXO34L
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

FBX46_MOUSE
NC score	0.102286 (rank : 32)	θ value	0.0961366 (rank : 24)
Query Neighborhood Hits	59	Target Neighborhood Hits	139	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BG80	Gene names	Fbxo46, Fbx46, Fbxo34l
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

FBX36_MOUSE
NC score	0.093376 (rank : 33)	θ value	1.81305 (rank : 42)
Query Neighborhood Hits	59	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	Q9CQ24	Gene names	Fbxo36
Domain Architecture	No domain graphic available
Description	F-box only protein 36.

FBX4_MOUSE
NC score	0.085442 (rank : 34)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	59	Target Neighborhood Hits	36	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CHQ0, Q99JG8	Gene names	Fbxo4, Fbx4
Domain Architecture	No domain graphic available
Description	F-box only protein 4.

FBXW7_MOUSE
NC score	0.069336 (rank : 35)	θ value	0.00228821 (rank : 9)
Query Neighborhood Hits	59	Target Neighborhood Hits	365	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VBV4, Q8CCS5, Q8VHP4	Gene names	Fbxw7, Fbw7, Fbwd6, Fbxw6
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10).

FBXW7_HUMAN
NC score	0.069027 (rank : 36)	θ value	0.00228821 (rank : 8)
Query Neighborhood Hits	59	Target Neighborhood Hits	433	Shared Neighborhood Hits	17
SwissProt Accessions	Q969H0, Q96A16, Q96LE0, Q96RI2, Q9NUX6	Gene names	FBXW7, FBW7, FBX30, SEL10
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBX30) (hCdc4) (Archipelago homolog) (hAgo) (SEL-10).

NEK9_MOUSE
NC score	0.068353 (rank : 37)	θ value	0.279714 (rank : 32)
Query Neighborhood Hits	59	Target Neighborhood Hits	890	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NEK9_HUMAN
NC score	0.067450 (rank : 38)	θ value	0.279714 (rank : 31)
Query Neighborhood Hits	59	Target Neighborhood Hits	900	Shared Neighborhood Hits	30
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK8_HUMAN
NC score	0.064922 (rank : 39)	θ value	0.21417 (rank : 28)
Query Neighborhood Hits	59	Target Neighborhood Hits	872	Shared Neighborhood Hits	30
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
NC score	0.060390 (rank : 40)	θ value	2.36792 (rank : 45)
Query Neighborhood Hits	59	Target Neighborhood Hits	872	Shared Neighborhood Hits	30
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

HTF4_HUMAN
NC score	0.060187 (rank : 41)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	59	Target Neighborhood Hits	152	Shared Neighborhood Hits	6
SwissProt Accessions	Q99081	Gene names	TCF12, HEB, HTF4
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4).

PHLD1_HUMAN
NC score	0.054486 (rank : 42)	θ value	0.21417 (rank : 29)
Query Neighborhood Hits	59	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	P80108, Q15128	Gene names	GPLD1, PIGPLD1
Domain Architecture
Description	Phosphatidylinositol-glycan-specific phospholipase D 1 precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein phospholipase D) (Glycosyl- phosphatidylinositol-specific phospholipase D).

FBX18_MOUSE
NC score	0.050620 (rank : 43)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	59	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K2I9, Q8C444, Q99KS0, Q9CTC6, Q9QZG7	Gene names	Fbxo18, Fbh1, Fbx18
Domain Architecture
Description	F-box only protein 18 (EC 3.6.1.-) (F-box DNA helicase 1).

PHLD2_HUMAN
NC score	0.049752 (rank : 44)	θ value	0.813845 (rank : 37)
Query Neighborhood Hits	59	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q15127	Gene names	GPLD2, PIGPLD2
Domain Architecture
Description	Phosphatidylinositol-glycan-specific phospholipase D 2 precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein phospholipase D) (Glycosyl- phosphatidylinositol-specific phospholipase D).

FBX32_MOUSE
NC score	0.049398 (rank : 45)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	59	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9CPU7	Gene names	Fbxo32
Domain Architecture	No domain graphic available
Description	F-box only protein 32 (Muscle atrophy F-box protein) (MAFbx) (Atrogin- 1).

FXL14_MOUSE
NC score	0.046271 (rank : 46)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	59	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BID8, Q3U2Q9, Q8R5H7, Q8VDT7, Q922N5	Gene names	Fbxl14, Fbl14, Ppa
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14).

FXL14_HUMAN
NC score	0.046228 (rank : 47)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	59	Target Neighborhood Hits	71	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N1E6	Gene names	FBXL14, FBL14
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14).

HTF4_MOUSE
NC score	0.045140 (rank : 48)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	59	Target Neighborhood Hits	153	Shared Neighborhood Hits	5
SwissProt Accessions	Q61286	Gene names	Tcf12, Alf1, Meb
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4) (Class A helix-loop-helix transcription factor ME1).

FBX18_HUMAN
NC score	0.044986 (rank : 49)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFZ0, Q7Z4Q6, Q7Z4R0, Q8N1P5, Q8N586, Q96E82, Q96K67, Q96SW7, Q9UFB2	Gene names	FBXO18, FBH1, FBX18
Domain Architecture
Description	F-box only protein 18 (EC 3.6.1.-) (F-box DNA helicase 1).

ITF2_MOUSE
NC score	0.040964 (rank : 50)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	59	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

ITF2_HUMAN
NC score	0.040920 (rank : 51)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	59	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

FBX32_HUMAN
NC score	0.037774 (rank : 52)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	59	Target Neighborhood Hits	14	Shared Neighborhood Hits	6
SwissProt Accessions	Q969P5	Gene names	FBXO32
Domain Architecture	No domain graphic available
Description	F-box only protein 32 (Muscle atrophy F-box protein) (MAFbx) (Atrogin- 1).

HECD1_HUMAN
NC score	0.026731 (rank : 53)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	59	Target Neighborhood Hits	371	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

FBXL3_MOUSE
NC score	0.021477 (rank : 54)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	59	Target Neighborhood Hits	37	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C4V4, Q80V32, Q8K1W0, Q9QXW1	Gene names	Fbxl3, Fbl3a, Fbxl3a
Domain Architecture
Description	F-box/LRR-repeat protein 3 (F-box/LRR-repeat protein 3A) (F-box and leucine-rich repeat protein 3A).

TSP3_HUMAN
NC score	0.017612 (rank : 55)	θ value	1.06291 (rank : 39)
Query Neighborhood Hits	59	Target Neighborhood Hits	250	Shared Neighborhood Hits	3
SwissProt Accessions	P49746, Q8WV34	Gene names	THBS3, TSP3
Domain Architecture
Description	Thrombospondin-3 precursor.

NHLC1_MOUSE
NC score	0.012705 (rank : 56)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	59	Target Neighborhood Hits	103	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BR37	Gene names	Nhlrc1, Epm2b
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

RIPK2_MOUSE
NC score	0.009167 (rank : 57)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	59	Target Neighborhood Hits	776	Shared Neighborhood Hits	7
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

NIN_MOUSE
NC score	0.006615 (rank : 58)	θ value	2.36792 (rank : 46)
Query Neighborhood Hits	59	Target Neighborhood Hits	1376	Shared Neighborhood Hits	3
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

TITIN_HUMAN
NC score	0.004663 (rank : 59)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	59	Target Neighborhood Hits	2923	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).