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Network neighborhood for query Sequence : SETD7_HUMAN

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SETD7_HUMAN
SwissProt Accessions	Q8WTS6, Q9C0E6	Gene names	SETD7, KIAA1717, SET7
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7) (Set9) (SET7/9).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SETD7_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	37	Target Neighborhood Hits	37	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WTS6, Q9C0E6	Gene names	SETD7, KIAA1717, SET7
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7) (Set9) (SET7/9).

SETD7_MOUSE
θ value	0 (rank : 2)	NC score	0.999403 (rank : 2)
Query Neighborhood Hits	37	Target Neighborhood Hits	39	Shared Neighborhood Hits	37
SwissProt Accessions	Q8VHL1	Gene names	Setd7, Set7
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7).

TSGA2_MOUSE
θ value	1.63604e-09 (rank : 3)	NC score	0.511537 (rank : 3)
Query Neighborhood Hits	37	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VIG3, Q9DAL5	Gene names	Tsga2
Domain Architecture	No domain graphic available
Description	Testis-specific gene A2 protein (Male meiotic metaphase chromosome- associated acidic protein) (Meichroacidin).

MORN1_HUMAN
θ value	4.76016e-09 (rank : 4)	NC score	0.495833 (rank : 4)
Query Neighborhood Hits	37	Target Neighborhood Hits	89	Shared Neighborhood Hits	20
SwissProt Accessions	Q5T089, Q8WW30, Q9H852	Gene names	MORN1
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 1.

TSGA2_HUMAN
θ value	8.97725e-08 (rank : 5)	NC score	0.486447 (rank : 5)
Query Neighborhood Hits	37	Target Neighborhood Hits	40	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WYR4	Gene names	TSGA2, TSA2
Domain Architecture
Description	Testis-specific gene A2 protein (Male meiotic metaphase chromosome- associated acidic protein) (Meichroacidin).

MORN3_MOUSE
θ value	8.40245e-06 (rank : 6)	NC score	0.431844 (rank : 6)
Query Neighborhood Hits	37	Target Neighborhood Hits	25	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C5T4, Q8VE21, Q9D5H6	Gene names	Morn3
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 3.

MORN3_HUMAN
θ value	4.1701e-05 (rank : 7)	NC score	0.423421 (rank : 7)
Query Neighborhood Hits	37	Target Neighborhood Hits	23	Shared Neighborhood Hits	20
SwissProt Accessions	Q6PF18, Q86YQ9	Gene names	MORN3
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 3.

ANKY1_HUMAN
θ value	5.44631e-05 (rank : 8)	NC score	0.270795 (rank : 10)
Query Neighborhood Hits	37	Target Neighborhood Hits	248	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

MORN2_MOUSE
θ value	0.00228821 (rank : 9)	NC score	0.414191 (rank : 8)
Query Neighborhood Hits	37	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q6UL01	Gene names	Morn2, Mopt
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 2 (MORN motif protein in testis).

EZH1_HUMAN
θ value	0.00298849 (rank : 10)	NC score	0.201830 (rank : 21)
Query Neighborhood Hits	37	Target Neighborhood Hits	121	Shared Neighborhood Hits	15
SwissProt Accessions	Q92800, O43287, Q14459	Gene names	EZH1, KIAA0388
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

EZH1_MOUSE
θ value	0.00298849 (rank : 11)	NC score	0.201679 (rank : 22)
Query Neighborhood Hits	37	Target Neighborhood Hits	126	Shared Neighborhood Hits	15
SwissProt Accessions	P70351, Q9R089	Gene names	Ezh1, Enx2
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

MORN2_HUMAN
θ value	0.00665767 (rank : 12)	NC score	0.411456 (rank : 9)
Query Neighborhood Hits	37	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q502X0, Q6UL00	Gene names	MORN2, MOPT
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 2 (MORN motif protein in testis).

ALS2_HUMAN
θ value	0.0252991 (rank : 13)	NC score	0.228384 (rank : 19)
Query Neighborhood Hits	37	Target Neighborhood Hits	121	Shared Neighborhood Hits	20
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	0.0252991 (rank : 14)	NC score	0.228579 (rank : 18)
Query Neighborhood Hits	37	Target Neighborhood Hits	111	Shared Neighborhood Hits	21
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

EZH2_HUMAN
θ value	0.0252991 (rank : 15)	NC score	0.190698 (rank : 23)
Query Neighborhood Hits	37	Target Neighborhood Hits	84	Shared Neighborhood Hits	14
SwissProt Accessions	Q15910, Q15755, Q92857	Gene names	EZH2
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

SUV91_HUMAN
θ value	0.0252991 (rank : 16)	NC score	0.148902 (rank : 25)
Query Neighborhood Hits	37	Target Neighborhood Hits	63	Shared Neighborhood Hits	15
SwissProt Accessions	O43463, Q53G60, Q6FHK6	Gene names	SUV39H1, SUV39H
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1).

EZH2_MOUSE
θ value	0.0563607 (rank : 17)	NC score	0.186831 (rank : 24)
Query Neighborhood Hits	37	Target Neighborhood Hits	86	Shared Neighborhood Hits	14
SwissProt Accessions	Q61188, Q9R090	Gene names	Ezh2, Enx1h
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

SUV91_MOUSE
θ value	0.0563607 (rank : 18)	NC score	0.143442 (rank : 26)
Query Neighborhood Hits	37	Target Neighborhood Hits	69	Shared Neighborhood Hits	15
SwissProt Accessions	O54864, Q9JLC7, Q9JLP8	Gene names	Suv39h1, Suv39h
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1) (Position-effect variegation 3-9 homolog).

JPH3_HUMAN
θ value	0.0961366 (rank : 19)	NC score	0.247937 (rank : 11)
Query Neighborhood Hits	37	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WXH2, Q8N471, Q9HDC3, Q9HDC4	Gene names	JPH3, JP3
Domain Architecture
Description	Junctophilin-3 (Junctophilin type 3) (JP-3).

JPH3_MOUSE
θ value	0.0961366 (rank : 20)	NC score	0.247114 (rank : 12)
Query Neighborhood Hits	37	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ET77, Q9EQZ2	Gene names	Jph3, Jp3
Domain Architecture
Description	Junctophilin-3 (Junctophilin type 3) (JP-3).

JPH2_HUMAN
θ value	0.163984 (rank : 21)	NC score	0.219858 (rank : 20)
Query Neighborhood Hits	37	Target Neighborhood Hits	639	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

JPH2_MOUSE
θ value	0.21417 (rank : 22)	NC score	0.232816 (rank : 16)
Query Neighborhood Hits	37	Target Neighborhood Hits	279	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

JPH4_HUMAN
θ value	0.279714 (rank : 23)	NC score	0.233101 (rank : 14)
Query Neighborhood Hits	37	Target Neighborhood Hits	103	Shared Neighborhood Hits	20
SwissProt Accessions	Q96JJ6, Q8ND44, Q96DQ0	Gene names	JPH4, JPHL1, KIAA1831
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

JPH4_MOUSE
θ value	0.279714 (rank : 24)	NC score	0.230431 (rank : 17)
Query Neighborhood Hits	37	Target Neighborhood Hits	102	Shared Neighborhood Hits	20
SwissProt Accessions	Q80WT0, Q8BMI1	Gene names	Jph4, Jphl1
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

JPH1_HUMAN
θ value	0.365318 (rank : 25)	NC score	0.233538 (rank : 13)
Query Neighborhood Hits	37	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HDC5	Gene names	JPH1, JP1
Domain Architecture	No domain graphic available
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

JPH1_MOUSE
θ value	0.365318 (rank : 26)	NC score	0.233074 (rank : 15)
Query Neighborhood Hits	37	Target Neighborhood Hits	120	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

MLL4_HUMAN
θ value	0.813845 (rank : 27)	NC score	0.095620 (rank : 29)
Query Neighborhood Hits	37	Target Neighborhood Hits	722	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

MLL3_HUMAN
θ value	1.06291 (rank : 28)	NC score	0.075601 (rank : 34)
Query Neighborhood Hits	37	Target Neighborhood Hits	1644	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

SET1A_HUMAN
θ value	1.06291 (rank : 29)	NC score	0.108149 (rank : 27)
Query Neighborhood Hits	37	Target Neighborhood Hits	690	Shared Neighborhood Hits	15
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

MLL3_MOUSE
θ value	1.38821 (rank : 30)	NC score	0.079240 (rank : 32)
Query Neighborhood Hits	37	Target Neighborhood Hits	1399	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

SMYD3_MOUSE
θ value	1.38821 (rank : 31)	NC score	0.050180 (rank : 43)
Query Neighborhood Hits	37	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q9CWR2, Q6P7V6, Q8BG90	Gene names	Smyd3, Zmynd1
Domain Architecture
Description	SET and MYND domain-containing protein 3 (EC 2.1.1.43) (Zinc finger MYND domain-containing protein 1).

MLL2_HUMAN
θ value	1.81305 (rank : 32)	NC score	0.072872 (rank : 38)
Query Neighborhood Hits	37	Target Neighborhood Hits	1788	Shared Neighborhood Hits	15
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

SETB2_HUMAN
θ value	1.81305 (rank : 33)	NC score	0.103273 (rank : 28)
Query Neighborhood Hits	37	Target Neighborhood Hits	62	Shared Neighborhood Hits	14
SwissProt Accessions	Q96T68, Q86UD6, Q96AI6	Gene names	SETDB2, CLLD8
Domain Architecture
Description	Probable histone-lysine N-methyltransferase, H3 lysine-9 specific (EC 2.1.1.43) (Histone H3-K9 methyltransferase) (H3-K9-HMTase) (SET domain bifurcated 2) (Chronic lymphocytic leukemia deletion region gene 8 protein).

ABCA2_HUMAN
θ value	4.03905 (rank : 34)	NC score	0.012488 (rank : 47)
Query Neighborhood Hits	37	Target Neighborhood Hits	143	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZC7	Gene names	ABCA2, ABC2
Domain Architecture
Description	ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2).

NOMO1_HUMAN
θ value	5.27518 (rank : 35)	NC score	0.040463 (rank : 45)
Query Neighborhood Hits	37	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	Q15155, P78421, Q8IW21, Q96DG0	Gene names	NOMO1, PM5
Domain Architecture	No domain graphic available
Description	Nodal modulator 1 precursor (pM5).

NOMO2_HUMAN
θ value	5.27518 (rank : 36)	NC score	0.040422 (rank : 46)
Query Neighborhood Hits	37	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q5JPE7	Gene names	NOMO2
Domain Architecture	No domain graphic available
Description	Nodal modulator 2 precursor (pM5 protein 2).

NOMO3_HUMAN
θ value	5.27518 (rank : 37)	NC score	0.040477 (rank : 44)
Query Neighborhood Hits	37	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	P69849	Gene names	NOMO3
Domain Architecture	No domain graphic available
Description	Nodal modulator 3 precursor (pM5 protein 3).

HRX_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.073454 (rank : 37)
Query Neighborhood Hits	37	Target Neighborhood Hits	825	Shared Neighborhood Hits	15
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

NSD1_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.059993 (rank : 40)
Query Neighborhood Hits	37	Target Neighborhood Hits	427	Shared Neighborhood Hits	13
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

NSD1_MOUSE
θ value	θ > 10 (rank : 40)	NC score	0.059828 (rank : 41)
Query Neighborhood Hits	37	Target Neighborhood Hits	472	Shared Neighborhood Hits	13
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

SETB1_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.057832 (rank : 42)
Query Neighborhood Hits	37	Target Neighborhood Hits	141	Shared Neighborhood Hits	12
SwissProt Accessions	Q15047, Q96GM9	Gene names	SETDB1, KIAA0067
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

SETB1_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.060133 (rank : 39)
Query Neighborhood Hits	37	Target Neighborhood Hits	150	Shared Neighborhood Hits	13
SwissProt Accessions	O88974, Q922K1	Gene names	Setdb1, Eset
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

SETD2_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.076129 (rank : 33)
Query Neighborhood Hits	37	Target Neighborhood Hits	412	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SETD8_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.075485 (rank : 35)
Query Neighborhood Hits	37	Target Neighborhood Hits	114	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NQR1, Q86W83, Q8TD09	Gene names	SETD8, PRSET7, SET07, SET8
Domain Architecture
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8) (PR/SET domain-containing protein 07) (PR/SET07) (PR-Set7).

SETD8_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.074940 (rank : 36)
Query Neighborhood Hits	37	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q2YDW7, Q8C0J9	Gene names	SETD8
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8).

SUV92_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.094459 (rank : 30)
Query Neighborhood Hits	37	Target Neighborhood Hits	54	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H5I1	Gene names	SUV39H2
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2).

SUV92_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.093302 (rank : 31)
Query Neighborhood Hits	37	Target Neighborhood Hits	59	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EQQ0, Q9CUK3, Q9JLP7	Gene names	Suv39h2
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2).

Hits sorted by NC score

SETD7_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	37	Target Neighborhood Hits	37	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WTS6, Q9C0E6	Gene names	SETD7, KIAA1717, SET7
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7) (Set9) (SET7/9).

SETD7_MOUSE
NC score	0.999403 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	37	Target Neighborhood Hits	39	Shared Neighborhood Hits	37
SwissProt Accessions	Q8VHL1	Gene names	Setd7, Set7
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7).

TSGA2_MOUSE
NC score	0.511537 (rank : 3)	θ value	1.63604e-09 (rank : 3)
Query Neighborhood Hits	37	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VIG3, Q9DAL5	Gene names	Tsga2
Domain Architecture	No domain graphic available
Description	Testis-specific gene A2 protein (Male meiotic metaphase chromosome- associated acidic protein) (Meichroacidin).

MORN1_HUMAN
NC score	0.495833 (rank : 4)	θ value	4.76016e-09 (rank : 4)
Query Neighborhood Hits	37	Target Neighborhood Hits	89	Shared Neighborhood Hits	20
SwissProt Accessions	Q5T089, Q8WW30, Q9H852	Gene names	MORN1
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 1.

TSGA2_HUMAN
NC score	0.486447 (rank : 5)	θ value	8.97725e-08 (rank : 5)
Query Neighborhood Hits	37	Target Neighborhood Hits	40	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WYR4	Gene names	TSGA2, TSA2
Domain Architecture
Description	Testis-specific gene A2 protein (Male meiotic metaphase chromosome- associated acidic protein) (Meichroacidin).

MORN3_MOUSE
NC score	0.431844 (rank : 6)	θ value	8.40245e-06 (rank : 6)
Query Neighborhood Hits	37	Target Neighborhood Hits	25	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C5T4, Q8VE21, Q9D5H6	Gene names	Morn3
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 3.

MORN3_HUMAN
NC score	0.423421 (rank : 7)	θ value	4.1701e-05 (rank : 7)
Query Neighborhood Hits	37	Target Neighborhood Hits	23	Shared Neighborhood Hits	20
SwissProt Accessions	Q6PF18, Q86YQ9	Gene names	MORN3
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 3.

MORN2_MOUSE
NC score	0.414191 (rank : 8)	θ value	0.00228821 (rank : 9)
Query Neighborhood Hits	37	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q6UL01	Gene names	Morn2, Mopt
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 2 (MORN motif protein in testis).

MORN2_HUMAN
NC score	0.411456 (rank : 9)	θ value	0.00665767 (rank : 12)
Query Neighborhood Hits	37	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q502X0, Q6UL00	Gene names	MORN2, MOPT
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 2 (MORN motif protein in testis).

ANKY1_HUMAN
NC score	0.270795 (rank : 10)	θ value	5.44631e-05 (rank : 8)
Query Neighborhood Hits	37	Target Neighborhood Hits	248	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

JPH3_HUMAN
NC score	0.247937 (rank : 11)	θ value	0.0961366 (rank : 19)
Query Neighborhood Hits	37	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WXH2, Q8N471, Q9HDC3, Q9HDC4	Gene names	JPH3, JP3
Domain Architecture
Description	Junctophilin-3 (Junctophilin type 3) (JP-3).

JPH3_MOUSE
NC score	0.247114 (rank : 12)	θ value	0.0961366 (rank : 20)
Query Neighborhood Hits	37	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ET77, Q9EQZ2	Gene names	Jph3, Jp3
Domain Architecture
Description	Junctophilin-3 (Junctophilin type 3) (JP-3).

JPH1_HUMAN
NC score	0.233538 (rank : 13)	θ value	0.365318 (rank : 25)
Query Neighborhood Hits	37	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HDC5	Gene names	JPH1, JP1
Domain Architecture	No domain graphic available
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

JPH4_HUMAN
NC score	0.233101 (rank : 14)	θ value	0.279714 (rank : 23)
Query Neighborhood Hits	37	Target Neighborhood Hits	103	Shared Neighborhood Hits	20
SwissProt Accessions	Q96JJ6, Q8ND44, Q96DQ0	Gene names	JPH4, JPHL1, KIAA1831
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

JPH1_MOUSE
NC score	0.233074 (rank : 15)	θ value	0.365318 (rank : 26)
Query Neighborhood Hits	37	Target Neighborhood Hits	120	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

JPH2_MOUSE
NC score	0.232816 (rank : 16)	θ value	0.21417 (rank : 22)
Query Neighborhood Hits	37	Target Neighborhood Hits	279	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

JPH4_MOUSE
NC score	0.230431 (rank : 17)	θ value	0.279714 (rank : 24)
Query Neighborhood Hits	37	Target Neighborhood Hits	102	Shared Neighborhood Hits	20
SwissProt Accessions	Q80WT0, Q8BMI1	Gene names	Jph4, Jphl1
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

ALS2_MOUSE
NC score	0.228579 (rank : 18)	θ value	0.0252991 (rank : 14)
Query Neighborhood Hits	37	Target Neighborhood Hits	111	Shared Neighborhood Hits	21
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ALS2_HUMAN
NC score	0.228384 (rank : 19)	θ value	0.0252991 (rank : 13)
Query Neighborhood Hits	37	Target Neighborhood Hits	121	Shared Neighborhood Hits	20
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

JPH2_HUMAN
NC score	0.219858 (rank : 20)	θ value	0.163984 (rank : 21)
Query Neighborhood Hits	37	Target Neighborhood Hits	639	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

EZH1_HUMAN
NC score	0.201830 (rank : 21)	θ value	0.00298849 (rank : 10)
Query Neighborhood Hits	37	Target Neighborhood Hits	121	Shared Neighborhood Hits	15
SwissProt Accessions	Q92800, O43287, Q14459	Gene names	EZH1, KIAA0388
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

EZH1_MOUSE
NC score	0.201679 (rank : 22)	θ value	0.00298849 (rank : 11)
Query Neighborhood Hits	37	Target Neighborhood Hits	126	Shared Neighborhood Hits	15
SwissProt Accessions	P70351, Q9R089	Gene names	Ezh1, Enx2
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

EZH2_HUMAN
NC score	0.190698 (rank : 23)	θ value	0.0252991 (rank : 15)
Query Neighborhood Hits	37	Target Neighborhood Hits	84	Shared Neighborhood Hits	14
SwissProt Accessions	Q15910, Q15755, Q92857	Gene names	EZH2
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

EZH2_MOUSE
NC score	0.186831 (rank : 24)	θ value	0.0563607 (rank : 17)
Query Neighborhood Hits	37	Target Neighborhood Hits	86	Shared Neighborhood Hits	14
SwissProt Accessions	Q61188, Q9R090	Gene names	Ezh2, Enx1h
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

SUV91_HUMAN
NC score	0.148902 (rank : 25)	θ value	0.0252991 (rank : 16)
Query Neighborhood Hits	37	Target Neighborhood Hits	63	Shared Neighborhood Hits	15
SwissProt Accessions	O43463, Q53G60, Q6FHK6	Gene names	SUV39H1, SUV39H
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1).

SUV91_MOUSE
NC score	0.143442 (rank : 26)	θ value	0.0563607 (rank : 18)
Query Neighborhood Hits	37	Target Neighborhood Hits	69	Shared Neighborhood Hits	15
SwissProt Accessions	O54864, Q9JLC7, Q9JLP8	Gene names	Suv39h1, Suv39h
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1) (Position-effect variegation 3-9 homolog).

SET1A_HUMAN
NC score	0.108149 (rank : 27)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	37	Target Neighborhood Hits	690	Shared Neighborhood Hits	15
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SETB2_HUMAN
NC score	0.103273 (rank : 28)	θ value	1.81305 (rank : 33)
Query Neighborhood Hits	37	Target Neighborhood Hits	62	Shared Neighborhood Hits	14
SwissProt Accessions	Q96T68, Q86UD6, Q96AI6	Gene names	SETDB2, CLLD8
Domain Architecture
Description	Probable histone-lysine N-methyltransferase, H3 lysine-9 specific (EC 2.1.1.43) (Histone H3-K9 methyltransferase) (H3-K9-HMTase) (SET domain bifurcated 2) (Chronic lymphocytic leukemia deletion region gene 8 protein).

MLL4_HUMAN
NC score	0.095620 (rank : 29)	θ value	0.813845 (rank : 27)
Query Neighborhood Hits	37	Target Neighborhood Hits	722	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

SUV92_HUMAN
NC score	0.094459 (rank : 30)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	37	Target Neighborhood Hits	54	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H5I1	Gene names	SUV39H2
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2).

SUV92_MOUSE
NC score	0.093302 (rank : 31)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	37	Target Neighborhood Hits	59	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EQQ0, Q9CUK3, Q9JLP7	Gene names	Suv39h2
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2).

MLL3_MOUSE
NC score	0.079240 (rank : 32)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	37	Target Neighborhood Hits	1399	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

SETD2_HUMAN
NC score	0.076129 (rank : 33)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	37	Target Neighborhood Hits	412	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

MLL3_HUMAN
NC score	0.075601 (rank : 34)	θ value	1.06291 (rank : 28)
Query Neighborhood Hits	37	Target Neighborhood Hits	1644	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

SETD8_HUMAN
NC score	0.075485 (rank : 35)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	37	Target Neighborhood Hits	114	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NQR1, Q86W83, Q8TD09	Gene names	SETD8, PRSET7, SET07, SET8
Domain Architecture
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8) (PR/SET domain-containing protein 07) (PR/SET07) (PR-Set7).

SETD8_MOUSE
NC score	0.074940 (rank : 36)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	37	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q2YDW7, Q8C0J9	Gene names	SETD8
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8).

HRX_HUMAN
NC score	0.073454 (rank : 37)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	37	Target Neighborhood Hits	825	Shared Neighborhood Hits	15
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

MLL2_HUMAN
NC score	0.072872 (rank : 38)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	37	Target Neighborhood Hits	1788	Shared Neighborhood Hits	15
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

SETB1_MOUSE
NC score	0.060133 (rank : 39)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	37	Target Neighborhood Hits	150	Shared Neighborhood Hits	13
SwissProt Accessions	O88974, Q922K1	Gene names	Setdb1, Eset
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

NSD1_HUMAN
NC score	0.059993 (rank : 40)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	37	Target Neighborhood Hits	427	Shared Neighborhood Hits	13
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

NSD1_MOUSE
NC score	0.059828 (rank : 41)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	37	Target Neighborhood Hits	472	Shared Neighborhood Hits	13
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

SETB1_HUMAN
NC score	0.057832 (rank : 42)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	37	Target Neighborhood Hits	141	Shared Neighborhood Hits	12
SwissProt Accessions	Q15047, Q96GM9	Gene names	SETDB1, KIAA0067
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

SMYD3_MOUSE
NC score	0.050180 (rank : 43)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	37	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q9CWR2, Q6P7V6, Q8BG90	Gene names	Smyd3, Zmynd1
Domain Architecture
Description	SET and MYND domain-containing protein 3 (EC 2.1.1.43) (Zinc finger MYND domain-containing protein 1).

NOMO3_HUMAN
NC score	0.040477 (rank : 44)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	37	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	P69849	Gene names	NOMO3
Domain Architecture	No domain graphic available
Description	Nodal modulator 3 precursor (pM5 protein 3).

NOMO1_HUMAN
NC score	0.040463 (rank : 45)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	37	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	Q15155, P78421, Q8IW21, Q96DG0	Gene names	NOMO1, PM5
Domain Architecture	No domain graphic available
Description	Nodal modulator 1 precursor (pM5).

NOMO2_HUMAN
NC score	0.040422 (rank : 46)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	37	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q5JPE7	Gene names	NOMO2
Domain Architecture	No domain graphic available
Description	Nodal modulator 2 precursor (pM5 protein 2).

ABCA2_HUMAN
NC score	0.012488 (rank : 47)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	37	Target Neighborhood Hits	143	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZC7	Gene names	ABCA2, ABC2
Domain Architecture
Description	ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2).