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Network neighborhood for query Sequence : SETB1_HUMAN

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SETB1_HUMAN
SwissProt Accessions	Q15047, Q96GM9	Gene names	SETDB1, KIAA0067
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SETB1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	141	Target Neighborhood Hits	141	Shared Neighborhood Hits	141
SwissProt Accessions	Q15047, Q96GM9	Gene names	SETDB1, KIAA0067
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

SETB1_MOUSE
θ value	0 (rank : 2)	NC score	0.977838 (rank : 2)
Query Neighborhood Hits	141	Target Neighborhood Hits	150	Shared Neighborhood Hits	62
SwissProt Accessions	O88974, Q922K1	Gene names	Setdb1, Eset
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

SETB2_HUMAN
θ value	1.96772e-63 (rank : 3)	NC score	0.855961 (rank : 3)
Query Neighborhood Hits	141	Target Neighborhood Hits	62	Shared Neighborhood Hits	27
SwissProt Accessions	Q96T68, Q86UD6, Q96AI6	Gene names	SETDB2, CLLD8
Domain Architecture
Description	Probable histone-lysine N-methyltransferase, H3 lysine-9 specific (EC 2.1.1.43) (Histone H3-K9 methyltransferase) (H3-K9-HMTase) (SET domain bifurcated 2) (Chronic lymphocytic leukemia deletion region gene 8 protein).

EHMT2_HUMAN
θ value	1.05554e-24 (rank : 4)	NC score	0.356773 (rank : 18)
Query Neighborhood Hits	141	Target Neighborhood Hits	498	Shared Neighborhood Hits	32
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

EHMT2_MOUSE
θ value	4.01107e-24 (rank : 5)	NC score	0.353924 (rank : 19)
Query Neighborhood Hits	141	Target Neighborhood Hits	750	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

EHMT1_HUMAN
θ value	1.16704e-23 (rank : 6)	NC score	0.348462 (rank : 20)
Query Neighborhood Hits	141	Target Neighborhood Hits	417	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

SUV91_HUMAN
θ value	1.5773e-20 (rank : 7)	NC score	0.652258 (rank : 4)
Query Neighborhood Hits	141	Target Neighborhood Hits	63	Shared Neighborhood Hits	24
SwissProt Accessions	O43463, Q53G60, Q6FHK6	Gene names	SUV39H1, SUV39H
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1).

SUV91_MOUSE
θ value	1.33526e-19 (rank : 8)	NC score	0.643508 (rank : 5)
Query Neighborhood Hits	141	Target Neighborhood Hits	69	Shared Neighborhood Hits	24
SwissProt Accessions	O54864, Q9JLC7, Q9JLP8	Gene names	Suv39h1, Suv39h
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1) (Position-effect variegation 3-9 homolog).

SUV92_MOUSE
θ value	1.80466e-16 (rank : 9)	NC score	0.625564 (rank : 6)
Query Neighborhood Hits	141	Target Neighborhood Hits	59	Shared Neighborhood Hits	24
SwissProt Accessions	Q9EQQ0, Q9CUK3, Q9JLP7	Gene names	Suv39h2
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2).

SUV92_HUMAN
θ value	3.40345e-15 (rank : 10)	NC score	0.625135 (rank : 7)
Query Neighborhood Hits	141	Target Neighborhood Hits	54	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H5I1	Gene names	SUV39H2
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2).

MLL4_HUMAN
θ value	3.89403e-11 (rank : 11)	NC score	0.428437 (rank : 14)
Query Neighborhood Hits	141	Target Neighborhood Hits	722	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

SETD2_HUMAN
θ value	1.9326e-10 (rank : 12)	NC score	0.518046 (rank : 8)
Query Neighborhood Hits	141	Target Neighborhood Hits	412	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

HRX_HUMAN
θ value	9.59137e-10 (rank : 13)	NC score	0.423731 (rank : 17)
Query Neighborhood Hits	141	Target Neighborhood Hits	825	Shared Neighborhood Hits	51
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

MLL2_HUMAN
θ value	1.63604e-09 (rank : 14)	NC score	0.333410 (rank : 21)
Query Neighborhood Hits	141	Target Neighborhood Hits	1788	Shared Neighborhood Hits	76
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MLL3_HUMAN
θ value	3.08544e-08 (rank : 15)	NC score	0.311801 (rank : 23)
Query Neighborhood Hits	141	Target Neighborhood Hits	1644	Shared Neighborhood Hits	68
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

NSD1_HUMAN
θ value	3.08544e-08 (rank : 16)	NC score	0.426938 (rank : 15)
Query Neighborhood Hits	141	Target Neighborhood Hits	427	Shared Neighborhood Hits	42
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

NSD1_MOUSE
θ value	3.08544e-08 (rank : 17)	NC score	0.424029 (rank : 16)
Query Neighborhood Hits	141	Target Neighborhood Hits	472	Shared Neighborhood Hits	42
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

MLL3_MOUSE
θ value	6.87365e-08 (rank : 18)	NC score	0.323580 (rank : 22)
Query Neighborhood Hits	141	Target Neighborhood Hits	1399	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

SET1A_HUMAN
θ value	1.99992e-07 (rank : 19)	NC score	0.458273 (rank : 12)
Query Neighborhood Hits	141	Target Neighborhood Hits	690	Shared Neighborhood Hits	50
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

EZH1_HUMAN
θ value	2.21117e-06 (rank : 20)	NC score	0.469558 (rank : 9)
Query Neighborhood Hits	141	Target Neighborhood Hits	121	Shared Neighborhood Hits	26
SwissProt Accessions	Q92800, O43287, Q14459	Gene names	EZH1, KIAA0388
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

EZH1_MOUSE
θ value	2.21117e-06 (rank : 21)	NC score	0.469129 (rank : 10)
Query Neighborhood Hits	141	Target Neighborhood Hits	126	Shared Neighborhood Hits	25
SwissProt Accessions	P70351, Q9R089	Gene names	Ezh1, Enx2
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

EZH2_HUMAN
θ value	1.09739e-05 (rank : 22)	NC score	0.464149 (rank : 11)
Query Neighborhood Hits	141	Target Neighborhood Hits	84	Shared Neighborhood Hits	25
SwissProt Accessions	Q15910, Q15755, Q92857	Gene names	EZH2
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

EZH2_MOUSE
θ value	5.44631e-05 (rank : 23)	NC score	0.456659 (rank : 13)
Query Neighborhood Hits	141	Target Neighborhood Hits	86	Shared Neighborhood Hits	25
SwissProt Accessions	Q61188, Q9R090	Gene names	Ezh2, Enx1h
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

LAD1_MOUSE
θ value	0.00509761 (rank : 24)	NC score	0.074397 (rank : 29)
Query Neighborhood Hits	141	Target Neighborhood Hits	391	Shared Neighborhood Hits	24
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

PSL1_HUMAN
θ value	0.00665767 (rank : 25)	NC score	0.065120 (rank : 34)
Query Neighborhood Hits	141	Target Neighborhood Hits	650	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

HN1_MOUSE
θ value	0.0736092 (rank : 26)	NC score	0.071729 (rank : 30)
Query Neighborhood Hits	141	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P97825	Gene names	Hn1
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1 protein.

MDC1_MOUSE
θ value	0.0736092 (rank : 27)	NC score	0.077205 (rank : 28)
Query Neighborhood Hits	141	Target Neighborhood Hits	998	Shared Neighborhood Hits	37
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

WDR7_HUMAN
θ value	0.0736092 (rank : 28)	NC score	0.034579 (rank : 84)
Query Neighborhood Hits	141	Target Neighborhood Hits	244	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4E6, Q86UX5, Q86VP2, Q96PS7	Gene names	WDR7, KIAA0541, TRAG
Domain Architecture	No domain graphic available
Description	WD repeat protein 7 (TGF-beta resistance-associated protein TRAG) (Rabconnectin-3 beta).

FIBA_HUMAN
θ value	0.0961366 (rank : 29)	NC score	0.025367 (rank : 111)
Query Neighborhood Hits	141	Target Neighborhood Hits	132	Shared Neighborhood Hits	5
SwissProt Accessions	P02671, Q9BX62, Q9UCH2	Gene names	FGA
Domain Architecture
Description	Fibrinogen alpha chain precursor [Contains: Fibrinopeptide A].

F126A_MOUSE
θ value	0.163984 (rank : 30)	NC score	0.057787 (rank : 51)
Query Neighborhood Hits	141	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P9N1, Q99NC4	Gene names	Fam126a, Drctnnb1a
Domain Architecture	No domain graphic available
Description	Protein FAM126A (Down-regulated by CTNNB1 protein A).

SPTN4_HUMAN
θ value	0.163984 (rank : 31)	NC score	0.041685 (rank : 75)
Query Neighborhood Hits	141	Target Neighborhood Hits	570	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

BAZ2B_HUMAN
θ value	0.21417 (rank : 32)	NC score	0.077614 (rank : 27)
Query Neighborhood Hits	141	Target Neighborhood Hits	803	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

CD2L7_HUMAN
θ value	0.279714 (rank : 33)	NC score	0.005506 (rank : 160)
Query Neighborhood Hits	141	Target Neighborhood Hits	1275	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

LTBP3_MOUSE
θ value	0.279714 (rank : 34)	NC score	0.022926 (rank : 117)
Query Neighborhood Hits	141	Target Neighborhood Hits	475	Shared Neighborhood Hits	11
SwissProt Accessions	Q61810, Q8BNQ6	Gene names	Ltbp3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

CHD2_HUMAN
θ value	0.365318 (rank : 35)	NC score	0.027651 (rank : 101)
Query Neighborhood Hits	141	Target Neighborhood Hits	360	Shared Neighborhood Hits	28
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

EXTL1_MOUSE
θ value	0.365318 (rank : 36)	NC score	0.025411 (rank : 110)
Query Neighborhood Hits	141	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JKV7	Gene names	Extl1
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).

AKAP2_MOUSE
θ value	0.47712 (rank : 37)	NC score	0.054119 (rank : 55)
Query Neighborhood Hits	141	Target Neighborhood Hits	385	Shared Neighborhood Hits	22
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

CBP_MOUSE
θ value	0.47712 (rank : 38)	NC score	0.046410 (rank : 67)
Query Neighborhood Hits	141	Target Neighborhood Hits	1051	Shared Neighborhood Hits	35
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

FOXD1_MOUSE
θ value	0.47712 (rank : 39)	NC score	0.011670 (rank : 145)
Query Neighborhood Hits	141	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	Q61345	Gene names	Foxd1, Fkhl8, Freac4, Hfhbf2
Domain Architecture
Description	Forkhead box protein D1 (Forkhead-related protein FKHL8) (Forkhead- related transcription factor 4) (FREAC-4) (Brain factor 2) (HFH-BF-2).

KIF4A_MOUSE
θ value	0.47712 (rank : 40)	NC score	0.024088 (rank : 115)
Query Neighborhood Hits	141	Target Neighborhood Hits	1033	Shared Neighborhood Hits	44
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

OR2J1_HUMAN
θ value	0.47712 (rank : 41)	NC score	0.002424 (rank : 166)
Query Neighborhood Hits	141	Target Neighborhood Hits	758	Shared Neighborhood Hits	4
SwissProt Accessions	Q9GZK6, Q9GZK1	Gene names	OR2J1
Domain Architecture
Description	Olfactory receptor 2J1 (Olfactory receptor 6-5) (OR6-5) (Hs6M1-4).

LTBP3_HUMAN
θ value	0.62314 (rank : 42)	NC score	0.020631 (rank : 123)
Query Neighborhood Hits	141	Target Neighborhood Hits	502	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

RN165_HUMAN
θ value	0.62314 (rank : 43)	NC score	0.029248 (rank : 95)
Query Neighborhood Hits	141	Target Neighborhood Hits	151	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZSG1	Gene names	RNF165
Domain Architecture	No domain graphic available
Description	RING finger protein 165.

BPA1_MOUSE
θ value	0.813845 (rank : 44)	NC score	0.033216 (rank : 86)
Query Neighborhood Hits	141	Target Neighborhood Hits	1477	Shared Neighborhood Hits	50
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BPAEA_MOUSE
θ value	0.813845 (rank : 45)	NC score	0.026271 (rank : 108)
Query Neighborhood Hits	141	Target Neighborhood Hits	1480	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CYTSA_HUMAN
θ value	0.813845 (rank : 46)	NC score	0.028023 (rank : 99)
Query Neighborhood Hits	141	Target Neighborhood Hits	1138	Shared Neighborhood Hits	43
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

MYH3_HUMAN
θ value	0.813845 (rank : 47)	NC score	0.021516 (rank : 121)
Query Neighborhood Hits	141	Target Neighborhood Hits	1660	Shared Neighborhood Hits	49
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

NFH_MOUSE
θ value	0.813845 (rank : 48)	NC score	0.043659 (rank : 72)
Query Neighborhood Hits	141	Target Neighborhood Hits	2247	Shared Neighborhood Hits	69
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

ANK2_HUMAN
θ value	1.06291 (rank : 49)	NC score	0.057768 (rank : 52)
Query Neighborhood Hits	141	Target Neighborhood Hits	1615	Shared Neighborhood Hits	50
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

DSPP_HUMAN
θ value	1.06291 (rank : 50)	NC score	0.046073 (rank : 68)
Query Neighborhood Hits	141	Target Neighborhood Hits	645	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

EP400_MOUSE
θ value	1.06291 (rank : 51)	NC score	0.033259 (rank : 85)
Query Neighborhood Hits	141	Target Neighborhood Hits	592	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

MYCD_HUMAN
θ value	1.06291 (rank : 52)	NC score	0.041987 (rank : 74)
Query Neighborhood Hits	141	Target Neighborhood Hits	167	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IZQ8, Q8N7Q1	Gene names	MYOCD, MYCD
Domain Architecture
Description	Myocardin.

ZF106_HUMAN
θ value	1.06291 (rank : 53)	NC score	0.029362 (rank : 92)
Query Neighborhood Hits	141	Target Neighborhood Hits	470	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

CNTRB_MOUSE
θ value	1.38821 (rank : 54)	NC score	0.030156 (rank : 90)
Query Neighborhood Hits	141	Target Neighborhood Hits	1029	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

HS74L_HUMAN
θ value	1.38821 (rank : 55)	NC score	0.015684 (rank : 131)
Query Neighborhood Hits	141	Target Neighborhood Hits	141	Shared Neighborhood Hits	11
SwissProt Accessions	O95757, Q4W5M5, Q8IWA2	Gene names	HSPA4L, APG1, OSP94
Domain Architecture
Description	Heat shock 70 kDa protein 4L (Osmotic stress protein 94) (Heat shock 70-related protein APG-1).

RASF8_MOUSE
θ value	1.38821 (rank : 56)	NC score	0.038936 (rank : 78)
Query Neighborhood Hits	141	Target Neighborhood Hits	391	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CJ96, Q8CCW4, Q9CU91	Gene names	Rassf8
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1 homolog).

ZIMP7_HUMAN
θ value	1.38821 (rank : 57)	NC score	0.024646 (rank : 113)
Query Neighborhood Hits	141	Target Neighborhood Hits	290	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

CNGB3_HUMAN
θ value	1.81305 (rank : 58)	NC score	0.016958 (rank : 129)
Query Neighborhood Hits	141	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CT055_MOUSE
θ value	1.81305 (rank : 59)	NC score	0.041202 (rank : 77)
Query Neighborhood Hits	141	Target Neighborhood Hits	52	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R184, Q8BQE5, Q8K024, Q8VEM7, Q9CU80	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf55 homolog.

CT2NL_MOUSE
θ value	1.81305 (rank : 60)	NC score	0.036909 (rank : 82)
Query Neighborhood Hits	141	Target Neighborhood Hits	902	Shared Neighborhood Hits	40
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

ETV4_HUMAN
θ value	1.81305 (rank : 61)	NC score	0.011065 (rank : 147)
Query Neighborhood Hits	141	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	P43268, Q96AW9	Gene names	ETV4, E1AF
Domain Architecture	No domain graphic available
Description	ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F).

GOGA1_HUMAN
θ value	1.81305 (rank : 62)	NC score	0.028679 (rank : 96)
Query Neighborhood Hits	141	Target Neighborhood Hits	1222	Shared Neighborhood Hits	42
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

MYH13_HUMAN
θ value	1.81305 (rank : 63)	NC score	0.015576 (rank : 132)
Query Neighborhood Hits	141	Target Neighborhood Hits	1504	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

RTP3_MOUSE
θ value	1.81305 (rank : 64)	NC score	0.050637 (rank : 62)
Query Neighborhood Hits	141	Target Neighborhood Hits	374	Shared Neighborhood Hits	22
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

SEC63_MOUSE
θ value	1.81305 (rank : 65)	NC score	0.032518 (rank : 87)
Query Neighborhood Hits	141	Target Neighborhood Hits	601	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

SPTN5_HUMAN
θ value	1.81305 (rank : 66)	NC score	0.031281 (rank : 88)
Query Neighborhood Hits	141	Target Neighborhood Hits	674	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

TMPS2_HUMAN
θ value	1.81305 (rank : 67)	NC score	0.007669 (rank : 156)
Query Neighborhood Hits	141	Target Neighborhood Hits	252	Shared Neighborhood Hits	5
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

EP15R_MOUSE
θ value	2.36792 (rank : 68)	NC score	0.028432 (rank : 97)
Query Neighborhood Hits	141	Target Neighborhood Hits	1135	Shared Neighborhood Hits	48
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

F126A_HUMAN
θ value	2.36792 (rank : 69)	NC score	0.044593 (rank : 71)
Query Neighborhood Hits	141	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYI3, Q6N010, Q75MR4, Q7LDZ4, Q96MX1, Q96NQ6	Gene names	FAM126A, DRCTNNB1A
Domain Architecture	No domain graphic available
Description	Protein FAM126A (Down-regulated by CTNNB1 protein A).

PRRT3_HUMAN
θ value	2.36792 (rank : 70)	NC score	0.037095 (rank : 81)
Query Neighborhood Hits	141	Target Neighborhood Hits	998	Shared Neighborhood Hits	27
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

ARNT_MOUSE
θ value	3.0926 (rank : 71)	NC score	0.014487 (rank : 136)
Query Neighborhood Hits	141	Target Neighborhood Hits	213	Shared Neighborhood Hits	7
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

DOT1L_HUMAN
θ value	3.0926 (rank : 72)	NC score	0.044956 (rank : 70)
Query Neighborhood Hits	141	Target Neighborhood Hits	660	Shared Neighborhood Hits	33
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

FLNB_HUMAN
θ value	3.0926 (rank : 73)	NC score	0.023677 (rank : 116)
Query Neighborhood Hits	141	Target Neighborhood Hits	111	Shared Neighborhood Hits	11
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

LEO1_MOUSE
θ value	3.0926 (rank : 74)	NC score	0.042521 (rank : 73)
Query Neighborhood Hits	141	Target Neighborhood Hits	946	Shared Neighborhood Hits	36
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

LRCH3_MOUSE
θ value	3.0926 (rank : 75)	NC score	0.006578 (rank : 157)
Query Neighborhood Hits	141	Target Neighborhood Hits	257	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BVU0, Q3U222, Q3UZ74	Gene names	Lrch3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 3 precursor.

MDC1_HUMAN
θ value	3.0926 (rank : 76)	NC score	0.065561 (rank : 32)
Query Neighborhood Hits	141	Target Neighborhood Hits	1446	Shared Neighborhood Hits	49
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MILK2_HUMAN
θ value	3.0926 (rank : 77)	NC score	0.048276 (rank : 65)
Query Neighborhood Hits	141	Target Neighborhood Hits	457	Shared Neighborhood Hits	36
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

NTNG1_HUMAN
θ value	3.0926 (rank : 78)	NC score	0.015379 (rank : 133)
Query Neighborhood Hits	141	Target Neighborhood Hits	247	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2I2, Q5VU86, Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633	Gene names	NTNG1, KIAA0976, LMNT1
Domain Architecture
Description	Netrin G1 precursor (Laminet-1).

OR2J3_HUMAN
θ value	3.0926 (rank : 79)	NC score	0.000259 (rank : 167)
Query Neighborhood Hits	141	Target Neighborhood Hits	748	Shared Neighborhood Hits	4
SwissProt Accessions	O76001, Q96R15, Q9GZK5, Q9GZL4, Q9GZL5	Gene names	OR2J3
Domain Architecture
Description	Olfactory receptor 2J3 (Olfactory receptor 6-6) (OR6-6) (Hs6M1-3).

SEC63_HUMAN
θ value	3.0926 (rank : 80)	NC score	0.035290 (rank : 83)
Query Neighborhood Hits	141	Target Neighborhood Hits	586	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

STAB2_MOUSE
θ value	3.0926 (rank : 81)	NC score	0.012821 (rank : 138)
Query Neighborhood Hits	141	Target Neighborhood Hits	528	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

TACC2_MOUSE
θ value	3.0926 (rank : 82)	NC score	0.029667 (rank : 91)
Query Neighborhood Hits	141	Target Neighborhood Hits	774	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

BLNK_MOUSE
θ value	4.03905 (rank : 83)	NC score	0.029350 (rank : 93)
Query Neighborhood Hits	141	Target Neighborhood Hits	296	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BPAEA_HUMAN
θ value	4.03905 (rank : 84)	NC score	0.027269 (rank : 103)
Query Neighborhood Hits	141	Target Neighborhood Hits	1369	Shared Neighborhood Hits	42
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

DDX58_MOUSE
θ value	4.03905 (rank : 85)	NC score	0.011772 (rank : 144)
Query Neighborhood Hits	141	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DSPP_MOUSE
θ value	4.03905 (rank : 86)	NC score	0.047541 (rank : 66)
Query Neighborhood Hits	141	Target Neighborhood Hits	491	Shared Neighborhood Hits	27
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

K1543_MOUSE
θ value	4.03905 (rank : 87)	NC score	0.041683 (rank : 76)
Query Neighborhood Hits	141	Target Neighborhood Hits	497	Shared Neighborhood Hits	26
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

NCOA7_MOUSE
θ value	4.03905 (rank : 88)	NC score	0.014936 (rank : 134)
Query Neighborhood Hits	141	Target Neighborhood Hits	114	Shared Neighborhood Hits	7
SwissProt Accessions	Q6DFV7, Q3TAR1, Q3UNB3, Q66K05, Q6ZQM4, Q8BJ15, Q8BJ39	Gene names	Ncoa7
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 7.

PITM1_HUMAN
θ value	4.03905 (rank : 89)	NC score	0.011094 (rank : 146)
Query Neighborhood Hits	141	Target Neighborhood Hits	129	Shared Neighborhood Hits	7
SwissProt Accessions	O00562, Q6T7X3, Q8TBN3, Q9BZ73	Gene names	PITPNM1, DRES9, NIR2, PITPNM
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog).

RRBP1_MOUSE
θ value	4.03905 (rank : 90)	NC score	0.030530 (rank : 89)
Query Neighborhood Hits	141	Target Neighborhood Hits	1650	Shared Neighborhood Hits	57
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

SELS_HUMAN
θ value	4.03905 (rank : 91)	NC score	0.025346 (rank : 112)
Query Neighborhood Hits	141	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BQE4, Q3B771, Q9P0I6	Gene names	SELS, VIMP
Domain Architecture
Description	Selenoprotein S (VCP-interacting membrane protein).

SEM6B_MOUSE
θ value	4.03905 (rank : 92)	NC score	0.006075 (rank : 158)
Query Neighborhood Hits	141	Target Neighborhood Hits	200	Shared Neighborhood Hits	3
SwissProt Accessions	O54951	Gene names	Sema6b, Seman
Domain Architecture
Description	Semaphorin-6B precursor (Semaphorin VIB) (Sema VIB) (Semaphorin N) (Sema N).

TCOF_MOUSE
θ value	4.03905 (rank : 93)	NC score	0.038329 (rank : 79)
Query Neighborhood Hits	141	Target Neighborhood Hits	471	Shared Neighborhood Hits	23
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

TMPS2_MOUSE
θ value	4.03905 (rank : 94)	NC score	0.004050 (rank : 164)
Query Neighborhood Hits	141	Target Neighborhood Hits	243	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TSC1_HUMAN
θ value	4.03905 (rank : 95)	NC score	0.026774 (rank : 106)
Query Neighborhood Hits	141	Target Neighborhood Hits	765	Shared Neighborhood Hits	36
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

CACB1_HUMAN
θ value	5.27518 (rank : 96)	NC score	0.012399 (rank : 140)
Query Neighborhood Hits	141	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	Q02641, O15331, Q02639, Q02640, Q9C085	Gene names	CACNB1, CACNLB1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

CACB1_MOUSE
θ value	5.27518 (rank : 97)	NC score	0.012349 (rank : 141)
Query Neighborhood Hits	141	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R3Z5, O88517, Q7TPF2, Q8R3Z6, Q9EPT9	Gene names	Cacnb1, Cacnlb1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

FOXO1_HUMAN
θ value	5.27518 (rank : 98)	NC score	0.008580 (rank : 155)
Query Neighborhood Hits	141	Target Neighborhood Hits	126	Shared Neighborhood Hits	3
SwissProt Accessions	Q12778, O43523, Q5VYC7, Q6NSK6	Gene names	FOXO1A, FKHR
Domain Architecture
Description	Forkhead box protein O1A (Forkhead in rhabdomyosarcoma).

GOGB1_HUMAN
θ value	5.27518 (rank : 99)	NC score	0.024345 (rank : 114)
Query Neighborhood Hits	141	Target Neighborhood Hits	2297	Shared Neighborhood Hits	62
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

JAG1_MOUSE
θ value	5.27518 (rank : 100)	NC score	0.010368 (rank : 151)
Query Neighborhood Hits	141	Target Neighborhood Hits	518	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

NFL_HUMAN
θ value	5.27518 (rank : 101)	NC score	0.009678 (rank : 152)
Query Neighborhood Hits	141	Target Neighborhood Hits	666	Shared Neighborhood Hits	33
SwissProt Accessions	P07196, Q16154, Q8IU72	Gene names	NEFL, NF68, NFL
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

PPRB_MOUSE
θ value	5.27518 (rank : 102)	NC score	0.029266 (rank : 94)
Query Neighborhood Hits	141	Target Neighborhood Hits	354	Shared Neighborhood Hits	23
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

SMCA2_HUMAN
θ value	5.27518 (rank : 103)	NC score	0.021097 (rank : 122)
Query Neighborhood Hits	141	Target Neighborhood Hits	503	Shared Neighborhood Hits	34
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

SSH3_HUMAN
θ value	5.27518 (rank : 104)	NC score	0.011887 (rank : 143)
Query Neighborhood Hits	141	Target Neighborhood Hits	75	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TE77, Q6PK42, Q76I75, Q8N9L8, Q8WYL0, Q9NV45, Q9NWZ7	Gene names	SSH3, SSH3L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L).

SYNE2_HUMAN
θ value	5.27518 (rank : 105)	NC score	0.027849 (rank : 100)
Query Neighborhood Hits	141	Target Neighborhood Hits	1323	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

TITIN_HUMAN
θ value	5.27518 (rank : 106)	NC score	0.005102 (rank : 161)
Query Neighborhood Hits	141	Target Neighborhood Hits	2923	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

WTAP_HUMAN
θ value	5.27518 (rank : 107)	NC score	0.028265 (rank : 98)
Query Neighborhood Hits	141	Target Neighborhood Hits	262	Shared Neighborhood Hits	19
SwissProt Accessions	Q15007, Q96T28, Q9BYJ7, Q9H4E2	Gene names	WTAP, KIAA0105
Domain Architecture	No domain graphic available
Description	Wilms' tumor 1-associating protein (WT1-associated protein) (Putative pre-mRNA-splicing regulator female-lethal(2D) homolog).

ZEP1_HUMAN
θ value	5.27518 (rank : 108)	NC score	0.006058 (rank : 159)
Query Neighborhood Hits	141	Target Neighborhood Hits	1036	Shared Neighborhood Hits	21
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

ZIC3_HUMAN
θ value	5.27518 (rank : 109)	NC score	-0.000886 (rank : 169)
Query Neighborhood Hits	141	Target Neighborhood Hits	714	Shared Neighborhood Hits	6
SwissProt Accessions	O60481	Gene names	ZIC3
Domain Architecture
Description	Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3).

ZIC3_MOUSE
θ value	5.27518 (rank : 110)	NC score	-0.000880 (rank : 168)
Query Neighborhood Hits	141	Target Neighborhood Hits	713	Shared Neighborhood Hits	6
SwissProt Accessions	Q62521	Gene names	Zic3
Domain Architecture
Description	Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3).

ZN335_HUMAN
θ value	5.27518 (rank : 111)	NC score	-0.001216 (rank : 170)
Query Neighborhood Hits	141	Target Neighborhood Hits	973	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H4Z2, Q9H684	Gene names	ZNF335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 335.

ATRX_MOUSE
θ value	6.88961 (rank : 112)	NC score	0.026477 (rank : 107)
Query Neighborhood Hits	141	Target Neighborhood Hits	682	Shared Neighborhood Hits	36
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

CENPE_HUMAN
θ value	6.88961 (rank : 113)	NC score	0.016009 (rank : 130)
Query Neighborhood Hits	141	Target Neighborhood Hits	2060	Shared Neighborhood Hits	51
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CT2NL_HUMAN
θ value	6.88961 (rank : 114)	NC score	0.026197 (rank : 109)
Query Neighborhood Hits	141	Target Neighborhood Hits	1059	Shared Neighborhood Hits	45
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

KRA11_HUMAN
θ value	6.88961 (rank : 115)	NC score	0.010615 (rank : 150)
Query Neighborhood Hits	141	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q07627, Q96S60, Q96S67	Gene names	KRTAP1-1, B2A, KAP1.1, KAP1.6, KAP1.7, KRTAP1.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 1-1 (Keratin-associated protein 1.1) (High sulfur keratin-associated protein 1.1) (Keratin-associated protein 1.6) (Keratin-associated protein 1.7).

MRE11_HUMAN
θ value	6.88961 (rank : 116)	NC score	0.013451 (rank : 137)
Query Neighborhood Hits	141	Target Neighborhood Hits	95	Shared Neighborhood Hits	5
SwissProt Accessions	P49959, O43475	Gene names	MRE11A, HNGS1, MRE11
Domain Architecture
Description	Double-strand break repair protein MRE11A (MRE11 homolog 1) (MRE11 meiotic recombination 11 homolog A).

PALB2_MOUSE
θ value	6.88961 (rank : 117)	NC score	0.014749 (rank : 135)
Query Neighborhood Hits	141	Target Neighborhood Hits	133	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U0P1, Q6NZG9, Q7TMQ4, Q8CEA9	Gene names	Palb2
Domain Architecture	No domain graphic available
Description	Partner and localizer of BRCA2.

POK3_HUMAN
θ value	6.88961 (rank : 118)	NC score	0.004817 (rank : 162)
Query Neighborhood Hits	141	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WJR5, O15312	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19q12 provirus ancestral Pol protein (HERV-K(C19) Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4) (RNase H); Integrase (IN)].

SMC1A_HUMAN
θ value	6.88961 (rank : 119)	NC score	0.018767 (rank : 127)
Query Neighborhood Hits	141	Target Neighborhood Hits	1346	Shared Neighborhood Hits	48
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SMC1A_MOUSE
θ value	6.88961 (rank : 120)	NC score	0.018794 (rank : 126)
Query Neighborhood Hits	141	Target Neighborhood Hits	1384	Shared Neighborhood Hits	50
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SON_HUMAN
θ value	6.88961 (rank : 121)	NC score	0.044999 (rank : 69)
Query Neighborhood Hits	141	Target Neighborhood Hits	1568	Shared Neighborhood Hits	46
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

UT14A_HUMAN
θ value	6.88961 (rank : 122)	NC score	0.019985 (rank : 124)
Query Neighborhood Hits	141	Target Neighborhood Hits	168	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BVJ6, Q5JYF1	Gene names	UTP14A
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO- 16).

VMDL3_HUMAN
θ value	6.88961 (rank : 123)	NC score	0.009082 (rank : 153)
Query Neighborhood Hits	141	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N1M1, Q8N356, Q8NFT9, Q9BR80	Gene names	VMD2L3
Domain Architecture
Description	Bestrophin-4 (Vitelliform macular dystrophy 2-like protein 3).

VPS72_MOUSE
θ value	6.88961 (rank : 124)	NC score	0.060362 (rank : 48)
Query Neighborhood Hits	141	Target Neighborhood Hits	286	Shared Neighborhood Hits	16
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

CENPJ_HUMAN
θ value	8.99809 (rank : 125)	NC score	0.018998 (rank : 125)
Query Neighborhood Hits	141	Target Neighborhood Hits	721	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

DYNA_HUMAN
θ value	8.99809 (rank : 126)	NC score	0.022308 (rank : 120)
Query Neighborhood Hits	141	Target Neighborhood Hits	1194	Shared Neighborhood Hits	48
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

FYB_HUMAN
θ value	8.99809 (rank : 127)	NC score	0.037485 (rank : 80)
Query Neighborhood Hits	141	Target Neighborhood Hits	379	Shared Neighborhood Hits	25
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GOGA4_MOUSE
θ value	8.99809 (rank : 128)	NC score	0.022771 (rank : 119)
Query Neighborhood Hits	141	Target Neighborhood Hits	1939	Shared Neighborhood Hits	60
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

JAG1_HUMAN
θ value	8.99809 (rank : 129)	NC score	0.008836 (rank : 154)
Query Neighborhood Hits	141	Target Neighborhood Hits	514	Shared Neighborhood Hits	11
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

MD1L1_HUMAN
θ value	8.99809 (rank : 130)	NC score	0.017859 (rank : 128)
Query Neighborhood Hits	141	Target Neighborhood Hits	893	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

NTNG1_MOUSE
θ value	8.99809 (rank : 131)	NC score	0.010918 (rank : 149)
Query Neighborhood Hits	141	Target Neighborhood Hits	246	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R4G0, Q68FE5, Q69ZU3, Q8R4F3, Q8R4F4, Q8R4F5, Q8R4F6, Q8R4F7, Q8R4F8, Q8R4F9, Q9ESR3, Q9ESR4, Q9ESR5, Q9ESR6, Q9ESR7, Q9ESR8	Gene names	Ntng1, Kiaa0976, Lmnt1
Domain Architecture
Description	Netrin G1 precursor (Laminet-1).

PDIP3_MOUSE
θ value	8.99809 (rank : 132)	NC score	0.011016 (rank : 148)
Query Neighborhood Hits	141	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BG81, Q6PE83, Q80X99, Q8CI28	Gene names	Poldip3
Domain Architecture	No domain graphic available
Description	Polymerase delta-interacting protein 3.

PLEC1_HUMAN
θ value	8.99809 (rank : 133)	NC score	0.027648 (rank : 102)
Query Neighborhood Hits	141	Target Neighborhood Hits	1326	Shared Neighborhood Hits	49
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

PZRN4_HUMAN
θ value	8.99809 (rank : 134)	NC score	0.004150 (rank : 163)
Query Neighborhood Hits	141	Target Neighborhood Hits	438	Shared Neighborhood Hits	9
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

RNF17_HUMAN
θ value	8.99809 (rank : 135)	NC score	0.012245 (rank : 142)
Query Neighborhood Hits	141	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BXT8, Q9BXT7	Gene names	RNF17
Domain Architecture
Description	RING finger protein 17.

SPTB1_MOUSE
θ value	8.99809 (rank : 136)	NC score	0.027178 (rank : 104)
Query Neighborhood Hits	141	Target Neighborhood Hits	543	Shared Neighborhood Hits	31
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SPTB2_MOUSE
θ value	8.99809 (rank : 137)	NC score	0.026780 (rank : 105)
Query Neighborhood Hits	141	Target Neighborhood Hits	770	Shared Neighborhood Hits	39
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TRI62_MOUSE
θ value	8.99809 (rank : 138)	NC score	0.003985 (rank : 165)
Query Neighborhood Hits	141	Target Neighborhood Hits	478	Shared Neighborhood Hits	17
SwissProt Accessions	Q80V85	Gene names	Trim62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRIPB_HUMAN
θ value	8.99809 (rank : 139)	NC score	0.022894 (rank : 118)
Query Neighborhood Hits	141	Target Neighborhood Hits	1587	Shared Neighborhood Hits	51
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

UBP35_HUMAN
θ value	8.99809 (rank : 140)	NC score	0.012674 (rank : 139)
Query Neighborhood Hits	141	Target Neighborhood Hits	223	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2H5	Gene names	USP35, KIAA1372, USP34
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.1.2.15) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35) (Deubiquitinating enzyme 35).

ZN445_HUMAN
θ value	8.99809 (rank : 141)	NC score	-0.002917 (rank : 171)
Query Neighborhood Hits	141	Target Neighborhood Hits	764	Shared Neighborhood Hits	6
SwissProt Accessions	P59923	Gene names	ZNF445, ZNF168
Domain Architecture
Description	Zinc finger protein 445.

ANR22_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.051178 (rank : 58)
Query Neighborhood Hits	141	Target Neighborhood Hits	243	Shared Neighborhood Hits	4
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

CBX1_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.063541 (rank : 37)
Query Neighborhood Hits	141	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	P83916, P23197	Gene names	CBX1, CBX
Domain Architecture
Description	Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25) (HP1Hsbeta) (p25beta).

CBX1_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.063541 (rank : 38)
Query Neighborhood Hits	141	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	P83917, P23197	Gene names	Cbx1, Cbx
Domain Architecture
Description	Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25).

CBX3_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.064540 (rank : 35)
Query Neighborhood Hits	141	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	Q13185, Q96CD7, Q99409, Q9BVS3, Q9P0Z6	Gene names	CBX3
Domain Architecture
Description	Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) (HECH).

CBX3_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.065174 (rank : 33)
Query Neighborhood Hits	141	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	P23198, Q921C4	Gene names	Cbx3
Domain Architecture
Description	Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) (M32).

CBX5_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.061462 (rank : 45)
Query Neighborhood Hits	141	Target Neighborhood Hits	70	Shared Neighborhood Hits	9
SwissProt Accessions	P45973	Gene names	CBX5, HP1A
Domain Architecture
Description	Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) (Antigen p25).

CBX5_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.060845 (rank : 47)
Query Neighborhood Hits	141	Target Neighborhood Hits	67	Shared Neighborhood Hits	8
SwissProt Accessions	Q61686, Q9CS35, Q9CXD1	Gene names	Cbx5, Hp1a
Domain Architecture
Description	Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha).

CBX7_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.050501 (rank : 64)
Query Neighborhood Hits	141	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VDS3	Gene names	Cbx7, D15Ertd417e
Domain Architecture
Description	Chromobox protein homolog 7.

DPF1_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.054793 (rank : 54)
Query Neighborhood Hits	141	Target Neighborhood Hits	136	Shared Neighborhood Hits	8
SwissProt Accessions	Q92782	Gene names	DPF1, NEUD4
Domain Architecture
Description	Zinc-finger protein neuro-d4 (D4, zinc and double PHD fingers family 1).

LAD1_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.061777 (rank : 44)
Query Neighborhood Hits	141	Target Neighborhood Hits	441	Shared Neighborhood Hits	24
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

MPP8_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.063004 (rank : 39)
Query Neighborhood Hits	141	Target Neighborhood Hits	948	Shared Neighborhood Hits	32
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

MYST4_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.050644 (rank : 61)
Query Neighborhood Hits	141	Target Neighborhood Hits	671	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

NACAM_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.050838 (rank : 59)
Query Neighborhood Hits	141	Target Neighborhood Hits	1866	Shared Neighborhood Hits	51
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PHF10_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.062863 (rank : 40)
Query Neighborhood Hits	141	Target Neighborhood Hits	151	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WUB8, Q2YDA3, Q9BXD2, Q9NV26	Gene names	PHF10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10 (XAP135).

PHF10_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.061377 (rank : 46)
Query Neighborhood Hits	141	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D8M7, Q99LV5	Gene names	Phf10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10.

PHF11_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.084712 (rank : 26)
Query Neighborhood Hits	141	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UIL8, Q9Y5A2	Gene names	PHF11, BCAP
Domain Architecture	No domain graphic available
Description	PHD finger protein 11 (BRCA1 C-terminus-associated protein) (NY-REN-34 antigen).

PHF6_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.064470 (rank : 36)
Query Neighborhood Hits	141	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IWS0, Q96JK3, Q9BRU0	Gene names	PHF6, KIAA1823
Domain Architecture	No domain graphic available
Description	PHD finger protein 6 (PHD-like zinc finger protein).

PHF6_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.062772 (rank : 41)
Query Neighborhood Hits	141	Target Neighborhood Hits	39	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D4J7, Q80T86, Q8BYT8, Q8C1B5	Gene names	Phf6, Kiaa1823
Domain Architecture	No domain graphic available
Description	PHD finger protein 6.

PHF7_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.050819 (rank : 60)
Query Neighborhood Hits	141	Target Neighborhood Hits	71	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BWX1	Gene names	PHF7
Domain Architecture	No domain graphic available
Description	PHD finger protein 7 (Testis development protein NYD-SP6).

RAI1_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.062551 (rank : 42)
Query Neighborhood Hits	141	Target Neighborhood Hits	360	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

RAI1_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.066741 (rank : 31)
Query Neighborhood Hits	141	Target Neighborhood Hits	344	Shared Neighborhood Hits	19
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

RSF1_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.051985 (rank : 57)
Query Neighborhood Hits	141	Target Neighborhood Hits	539	Shared Neighborhood Hits	38
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

SETD7_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.057832 (rank : 50)
Query Neighborhood Hits	141	Target Neighborhood Hits	37	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WTS6, Q9C0E6	Gene names	SETD7, KIAA1717, SET7
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7) (Set9) (SET7/9).

SETD7_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.058870 (rank : 49)
Query Neighborhood Hits	141	Target Neighborhood Hits	39	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VHL1	Gene names	Setd7, Set7
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7).

SETD8_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.308985 (rank : 25)
Query Neighborhood Hits	141	Target Neighborhood Hits	114	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NQR1, Q86W83, Q8TD09	Gene names	SETD8, PRSET7, SET07, SET8
Domain Architecture
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8) (PR/SET domain-containing protein 07) (PR/SET07) (PR-Set7).

SETD8_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.310906 (rank : 24)
Query Neighborhood Hits	141	Target Neighborhood Hits	131	Shared Neighborhood Hits	25
SwissProt Accessions	Q2YDW7, Q8C0J9	Gene names	SETD8
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8).

SRRM1_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.050582 (rank : 63)
Query Neighborhood Hits	141	Target Neighborhood Hits	966	Shared Neighborhood Hits	37
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

TARSH_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.053273 (rank : 56)
Query Neighborhood Hits	141	Target Neighborhood Hits	768	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TCF20_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.062082 (rank : 43)
Query Neighborhood Hits	141	Target Neighborhood Hits	323	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

TCF20_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.056976 (rank : 53)
Query Neighborhood Hits	141	Target Neighborhood Hits	396	Shared Neighborhood Hits	20
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

Hits sorted by NC score

SETB1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	141	Target Neighborhood Hits	141	Shared Neighborhood Hits	141
SwissProt Accessions	Q15047, Q96GM9	Gene names	SETDB1, KIAA0067
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

SETB1_MOUSE
NC score	0.977838 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	141	Target Neighborhood Hits	150	Shared Neighborhood Hits	62
SwissProt Accessions	O88974, Q922K1	Gene names	Setdb1, Eset
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

SETB2_HUMAN
NC score	0.855961 (rank : 3)	θ value	1.96772e-63 (rank : 3)
Query Neighborhood Hits	141	Target Neighborhood Hits	62	Shared Neighborhood Hits	27
SwissProt Accessions	Q96T68, Q86UD6, Q96AI6	Gene names	SETDB2, CLLD8
Domain Architecture
Description	Probable histone-lysine N-methyltransferase, H3 lysine-9 specific (EC 2.1.1.43) (Histone H3-K9 methyltransferase) (H3-K9-HMTase) (SET domain bifurcated 2) (Chronic lymphocytic leukemia deletion region gene 8 protein).

SUV91_HUMAN
NC score	0.652258 (rank : 4)	θ value	1.5773e-20 (rank : 7)
Query Neighborhood Hits	141	Target Neighborhood Hits	63	Shared Neighborhood Hits	24
SwissProt Accessions	O43463, Q53G60, Q6FHK6	Gene names	SUV39H1, SUV39H
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1).

SUV91_MOUSE
NC score	0.643508 (rank : 5)	θ value	1.33526e-19 (rank : 8)
Query Neighborhood Hits	141	Target Neighborhood Hits	69	Shared Neighborhood Hits	24
SwissProt Accessions	O54864, Q9JLC7, Q9JLP8	Gene names	Suv39h1, Suv39h
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1) (Position-effect variegation 3-9 homolog).

SUV92_MOUSE
NC score	0.625564 (rank : 6)	θ value	1.80466e-16 (rank : 9)
Query Neighborhood Hits	141	Target Neighborhood Hits	59	Shared Neighborhood Hits	24
SwissProt Accessions	Q9EQQ0, Q9CUK3, Q9JLP7	Gene names	Suv39h2
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2).

SUV92_HUMAN
NC score	0.625135 (rank : 7)	θ value	3.40345e-15 (rank : 10)
Query Neighborhood Hits	141	Target Neighborhood Hits	54	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H5I1	Gene names	SUV39H2
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2).

SETD2_HUMAN
NC score	0.518046 (rank : 8)	θ value	1.9326e-10 (rank : 12)
Query Neighborhood Hits	141	Target Neighborhood Hits	412	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

EZH1_HUMAN
NC score	0.469558 (rank : 9)	θ value	2.21117e-06 (rank : 20)
Query Neighborhood Hits	141	Target Neighborhood Hits	121	Shared Neighborhood Hits	26
SwissProt Accessions	Q92800, O43287, Q14459	Gene names	EZH1, KIAA0388
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

EZH1_MOUSE
NC score	0.469129 (rank : 10)	θ value	2.21117e-06 (rank : 21)
Query Neighborhood Hits	141	Target Neighborhood Hits	126	Shared Neighborhood Hits	25
SwissProt Accessions	P70351, Q9R089	Gene names	Ezh1, Enx2
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

EZH2_HUMAN
NC score	0.464149 (rank : 11)	θ value	1.09739e-05 (rank : 22)
Query Neighborhood Hits	141	Target Neighborhood Hits	84	Shared Neighborhood Hits	25
SwissProt Accessions	Q15910, Q15755, Q92857	Gene names	EZH2
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

SET1A_HUMAN
NC score	0.458273 (rank : 12)	θ value	1.99992e-07 (rank : 19)
Query Neighborhood Hits	141	Target Neighborhood Hits	690	Shared Neighborhood Hits	50
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

EZH2_MOUSE
NC score	0.456659 (rank : 13)	θ value	5.44631e-05 (rank : 23)
Query Neighborhood Hits	141	Target Neighborhood Hits	86	Shared Neighborhood Hits	25
SwissProt Accessions	Q61188, Q9R090	Gene names	Ezh2, Enx1h
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

MLL4_HUMAN
NC score	0.428437 (rank : 14)	θ value	3.89403e-11 (rank : 11)
Query Neighborhood Hits	141	Target Neighborhood Hits	722	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

NSD1_HUMAN
NC score	0.426938 (rank : 15)	θ value	3.08544e-08 (rank : 16)
Query Neighborhood Hits	141	Target Neighborhood Hits	427	Shared Neighborhood Hits	42
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

NSD1_MOUSE
NC score	0.424029 (rank : 16)	θ value	3.08544e-08 (rank : 17)
Query Neighborhood Hits	141	Target Neighborhood Hits	472	Shared Neighborhood Hits	42
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

HRX_HUMAN
NC score	0.423731 (rank : 17)	θ value	9.59137e-10 (rank : 13)
Query Neighborhood Hits	141	Target Neighborhood Hits	825	Shared Neighborhood Hits	51
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

EHMT2_HUMAN
NC score	0.356773 (rank : 18)	θ value	1.05554e-24 (rank : 4)
Query Neighborhood Hits	141	Target Neighborhood Hits	498	Shared Neighborhood Hits	32
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

EHMT2_MOUSE
NC score	0.353924 (rank : 19)	θ value	4.01107e-24 (rank : 5)
Query Neighborhood Hits	141	Target Neighborhood Hits	750	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

EHMT1_HUMAN
NC score	0.348462 (rank : 20)	θ value	1.16704e-23 (rank : 6)
Query Neighborhood Hits	141	Target Neighborhood Hits	417	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

MLL2_HUMAN
NC score	0.333410 (rank : 21)	θ value	1.63604e-09 (rank : 14)
Query Neighborhood Hits	141	Target Neighborhood Hits	1788	Shared Neighborhood Hits	76
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MLL3_MOUSE
NC score	0.323580 (rank : 22)	θ value	6.87365e-08 (rank : 18)
Query Neighborhood Hits	141	Target Neighborhood Hits	1399	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MLL3_HUMAN
NC score	0.311801 (rank : 23)	θ value	3.08544e-08 (rank : 15)
Query Neighborhood Hits	141	Target Neighborhood Hits	1644	Shared Neighborhood Hits	68
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

SETD8_MOUSE
NC score	0.310906 (rank : 24)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	141	Target Neighborhood Hits	131	Shared Neighborhood Hits	25
SwissProt Accessions	Q2YDW7, Q8C0J9	Gene names	SETD8
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8).

SETD8_HUMAN
NC score	0.308985 (rank : 25)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	141	Target Neighborhood Hits	114	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NQR1, Q86W83, Q8TD09	Gene names	SETD8, PRSET7, SET07, SET8
Domain Architecture
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8) (PR/SET domain-containing protein 07) (PR/SET07) (PR-Set7).

PHF11_HUMAN
NC score	0.084712 (rank : 26)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	141	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UIL8, Q9Y5A2	Gene names	PHF11, BCAP
Domain Architecture	No domain graphic available
Description	PHD finger protein 11 (BRCA1 C-terminus-associated protein) (NY-REN-34 antigen).

BAZ2B_HUMAN
NC score	0.077614 (rank : 27)	θ value	0.21417 (rank : 32)
Query Neighborhood Hits	141	Target Neighborhood Hits	803	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

MDC1_MOUSE
NC score	0.077205 (rank : 28)	θ value	0.0736092 (rank : 27)
Query Neighborhood Hits	141	Target Neighborhood Hits	998	Shared Neighborhood Hits	37
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

LAD1_MOUSE
NC score	0.074397 (rank : 29)	θ value	0.00509761 (rank : 24)
Query Neighborhood Hits	141	Target Neighborhood Hits	391	Shared Neighborhood Hits	24
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

HN1_MOUSE
NC score	0.071729 (rank : 30)	θ value	0.0736092 (rank : 26)
Query Neighborhood Hits	141	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P97825	Gene names	Hn1
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1 protein.

RAI1_MOUSE
NC score	0.066741 (rank : 31)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	141	Target Neighborhood Hits	344	Shared Neighborhood Hits	19
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

MDC1_HUMAN
NC score	0.065561 (rank : 32)	θ value	3.0926 (rank : 76)
Query Neighborhood Hits	141	Target Neighborhood Hits	1446	Shared Neighborhood Hits	49
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

CBX3_MOUSE
NC score	0.065174 (rank : 33)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	141	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	P23198, Q921C4	Gene names	Cbx3
Domain Architecture
Description	Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) (M32).

PSL1_HUMAN
NC score	0.065120 (rank : 34)	θ value	0.00665767 (rank : 25)
Query Neighborhood Hits	141	Target Neighborhood Hits	650	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

CBX3_HUMAN
NC score	0.064540 (rank : 35)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	141	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	Q13185, Q96CD7, Q99409, Q9BVS3, Q9P0Z6	Gene names	CBX3
Domain Architecture
Description	Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) (HECH).

PHF6_HUMAN
NC score	0.064470 (rank : 36)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	141	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IWS0, Q96JK3, Q9BRU0	Gene names	PHF6, KIAA1823
Domain Architecture	No domain graphic available
Description	PHD finger protein 6 (PHD-like zinc finger protein).

CBX1_HUMAN
NC score	0.063541 (rank : 37)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	141	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	P83916, P23197	Gene names	CBX1, CBX
Domain Architecture
Description	Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25) (HP1Hsbeta) (p25beta).

CBX1_MOUSE
NC score	0.063541 (rank : 38)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	141	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	P83917, P23197	Gene names	Cbx1, Cbx
Domain Architecture
Description	Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25).

MPP8_HUMAN
NC score	0.063004 (rank : 39)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	141	Target Neighborhood Hits	948	Shared Neighborhood Hits	32
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

PHF10_HUMAN
NC score	0.062863 (rank : 40)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	141	Target Neighborhood Hits	151	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WUB8, Q2YDA3, Q9BXD2, Q9NV26	Gene names	PHF10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10 (XAP135).

PHF6_MOUSE
NC score	0.062772 (rank : 41)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	141	Target Neighborhood Hits	39	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D4J7, Q80T86, Q8BYT8, Q8C1B5	Gene names	Phf6, Kiaa1823
Domain Architecture	No domain graphic available
Description	PHD finger protein 6.

RAI1_HUMAN
NC score	0.062551 (rank : 42)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	141	Target Neighborhood Hits	360	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

TCF20_HUMAN
NC score	0.062082 (rank : 43)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	141	Target Neighborhood Hits	323	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

LAD1_HUMAN
NC score	0.061777 (rank : 44)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	141	Target Neighborhood Hits	441	Shared Neighborhood Hits	24
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

CBX5_HUMAN
NC score	0.061462 (rank : 45)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	141	Target Neighborhood Hits	70	Shared Neighborhood Hits	9
SwissProt Accessions	P45973	Gene names	CBX5, HP1A
Domain Architecture
Description	Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) (Antigen p25).

PHF10_MOUSE
NC score	0.061377 (rank : 46)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	141	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D8M7, Q99LV5	Gene names	Phf10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10.

CBX5_MOUSE
NC score	0.060845 (rank : 47)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	141	Target Neighborhood Hits	67	Shared Neighborhood Hits	8
SwissProt Accessions	Q61686, Q9CS35, Q9CXD1	Gene names	Cbx5, Hp1a
Domain Architecture
Description	Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha).

VPS72_MOUSE
NC score	0.060362 (rank : 48)	θ value	6.88961 (rank : 124)
Query Neighborhood Hits	141	Target Neighborhood Hits	286	Shared Neighborhood Hits	16
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

SETD7_MOUSE
NC score	0.058870 (rank : 49)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	141	Target Neighborhood Hits	39	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VHL1	Gene names	Setd7, Set7
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7).

SETD7_HUMAN
NC score	0.057832 (rank : 50)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	141	Target Neighborhood Hits	37	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WTS6, Q9C0E6	Gene names	SETD7, KIAA1717, SET7
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7) (Set9) (SET7/9).

F126A_MOUSE
NC score	0.057787 (rank : 51)	θ value	0.163984 (rank : 30)
Query Neighborhood Hits	141	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P9N1, Q99NC4	Gene names	Fam126a, Drctnnb1a
Domain Architecture	No domain graphic available
Description	Protein FAM126A (Down-regulated by CTNNB1 protein A).

ANK2_HUMAN
NC score	0.057768 (rank : 52)	θ value	1.06291 (rank : 49)
Query Neighborhood Hits	141	Target Neighborhood Hits	1615	Shared Neighborhood Hits	50
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

TCF20_MOUSE
NC score	0.056976 (rank : 53)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	141	Target Neighborhood Hits	396	Shared Neighborhood Hits	20
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

DPF1_HUMAN
NC score	0.054793 (rank : 54)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	141	Target Neighborhood Hits	136	Shared Neighborhood Hits	8
SwissProt Accessions	Q92782	Gene names	DPF1, NEUD4
Domain Architecture
Description	Zinc-finger protein neuro-d4 (D4, zinc and double PHD fingers family 1).

AKAP2_MOUSE
NC score	0.054119 (rank : 55)	θ value	0.47712 (rank : 37)
Query Neighborhood Hits	141	Target Neighborhood Hits	385	Shared Neighborhood Hits	22
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

TARSH_HUMAN
NC score	0.053273 (rank : 56)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	141	Target Neighborhood Hits	768	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

RSF1_HUMAN
NC score	0.051985 (rank : 57)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	141	Target Neighborhood Hits	539	Shared Neighborhood Hits	38
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

ANR22_HUMAN
NC score	0.051178 (rank : 58)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	141	Target Neighborhood Hits	243	Shared Neighborhood Hits	4
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

NACAM_MOUSE
NC score	0.050838 (rank : 59)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	141	Target Neighborhood Hits	1866	Shared Neighborhood Hits	51
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PHF7_HUMAN
NC score	0.050819 (rank : 60)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	141	Target Neighborhood Hits	71	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BWX1	Gene names	PHF7
Domain Architecture	No domain graphic available
Description	PHD finger protein 7 (Testis development protein NYD-SP6).

MYST4_HUMAN
NC score	0.050644 (rank : 61)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	141	Target Neighborhood Hits	671	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

RTP3_MOUSE
NC score	0.050637 (rank : 62)	θ value	1.81305 (rank : 64)
Query Neighborhood Hits	141	Target Neighborhood Hits	374	Shared Neighborhood Hits	22
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

SRRM1_MOUSE
NC score	0.050582 (rank : 63)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	141	Target Neighborhood Hits	966	Shared Neighborhood Hits	37
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

CBX7_MOUSE
NC score	0.050501 (rank : 64)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	141	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VDS3	Gene names	Cbx7, D15Ertd417e
Domain Architecture
Description	Chromobox protein homolog 7.

MILK2_HUMAN
NC score	0.048276 (rank : 65)	θ value	3.0926 (rank : 77)
Query Neighborhood Hits	141	Target Neighborhood Hits	457	Shared Neighborhood Hits	36
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

DSPP_MOUSE
NC score	0.047541 (rank : 66)	θ value	4.03905 (rank : 86)
Query Neighborhood Hits	141	Target Neighborhood Hits	491	Shared Neighborhood Hits	27
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

CBP_MOUSE
NC score	0.046410 (rank : 67)	θ value	0.47712 (rank : 38)
Query Neighborhood Hits	141	Target Neighborhood Hits	1051	Shared Neighborhood Hits	35
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

DSPP_HUMAN
NC score	0.046073 (rank : 68)	θ value	1.06291 (rank : 50)
Query Neighborhood Hits	141	Target Neighborhood Hits	645	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

SON_HUMAN
NC score	0.044999 (rank : 69)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	141	Target Neighborhood Hits	1568	Shared Neighborhood Hits	46
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

DOT1L_HUMAN
NC score	0.044956 (rank : 70)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	141	Target Neighborhood Hits	660	Shared Neighborhood Hits	33
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

F126A_HUMAN
NC score	0.044593 (rank : 71)	θ value	2.36792 (rank : 69)
Query Neighborhood Hits	141	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYI3, Q6N010, Q75MR4, Q7LDZ4, Q96MX1, Q96NQ6	Gene names	FAM126A, DRCTNNB1A
Domain Architecture	No domain graphic available
Description	Protein FAM126A (Down-regulated by CTNNB1 protein A).

NFH_MOUSE
NC score	0.043659 (rank : 72)	θ value	0.813845 (rank : 48)
Query Neighborhood Hits	141	Target Neighborhood Hits	2247	Shared Neighborhood Hits	69
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

LEO1_MOUSE
NC score	0.042521 (rank : 73)	θ value	3.0926 (rank : 74)
Query Neighborhood Hits	141	Target Neighborhood Hits	946	Shared Neighborhood Hits	36
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

MYCD_HUMAN
NC score	0.041987 (rank : 74)	θ value	1.06291 (rank : 52)
Query Neighborhood Hits	141	Target Neighborhood Hits	167	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IZQ8, Q8N7Q1	Gene names	MYOCD, MYCD
Domain Architecture
Description	Myocardin.

SPTN4_HUMAN
NC score	0.041685 (rank : 75)	θ value	0.163984 (rank : 31)
Query Neighborhood Hits	141	Target Neighborhood Hits	570	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

K1543_MOUSE
NC score	0.041683 (rank : 76)	θ value	4.03905 (rank : 87)
Query Neighborhood Hits	141	Target Neighborhood Hits	497	Shared Neighborhood Hits	26
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

CT055_MOUSE
NC score	0.041202 (rank : 77)	θ value	1.81305 (rank : 59)
Query Neighborhood Hits	141	Target Neighborhood Hits	52	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R184, Q8BQE5, Q8K024, Q8VEM7, Q9CU80	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf55 homolog.

RASF8_MOUSE
NC score	0.038936 (rank : 78)	θ value	1.38821 (rank : 56)
Query Neighborhood Hits	141	Target Neighborhood Hits	391	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CJ96, Q8CCW4, Q9CU91	Gene names	Rassf8
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1 homolog).

TCOF_MOUSE
NC score	0.038329 (rank : 79)	θ value	4.03905 (rank : 93)
Query Neighborhood Hits	141	Target Neighborhood Hits	471	Shared Neighborhood Hits	23
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

FYB_HUMAN
NC score	0.037485 (rank : 80)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	141	Target Neighborhood Hits	379	Shared Neighborhood Hits	25
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

PRRT3_HUMAN
NC score	0.037095 (rank : 81)	θ value	2.36792 (rank : 70)
Query Neighborhood Hits	141	Target Neighborhood Hits	998	Shared Neighborhood Hits	27
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

CT2NL_MOUSE
NC score	0.036909 (rank : 82)	θ value	1.81305 (rank : 60)
Query Neighborhood Hits	141	Target Neighborhood Hits	902	Shared Neighborhood Hits	40
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

SEC63_HUMAN
NC score	0.035290 (rank : 83)	θ value	3.0926 (rank : 80)
Query Neighborhood Hits	141	Target Neighborhood Hits	586	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

WDR7_HUMAN
NC score	0.034579 (rank : 84)	θ value	0.0736092 (rank : 28)
Query Neighborhood Hits	141	Target Neighborhood Hits	244	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4E6, Q86UX5, Q86VP2, Q96PS7	Gene names	WDR7, KIAA0541, TRAG
Domain Architecture	No domain graphic available
Description	WD repeat protein 7 (TGF-beta resistance-associated protein TRAG) (Rabconnectin-3 beta).

EP400_MOUSE
NC score	0.033259 (rank : 85)	θ value	1.06291 (rank : 51)
Query Neighborhood Hits	141	Target Neighborhood Hits	592	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

BPA1_MOUSE
NC score	0.033216 (rank : 86)	θ value	0.813845 (rank : 44)
Query Neighborhood Hits	141	Target Neighborhood Hits	1477	Shared Neighborhood Hits	50
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

SEC63_MOUSE
NC score	0.032518 (rank : 87)	θ value	1.81305 (rank : 65)
Query Neighborhood Hits	141	Target Neighborhood Hits	601	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

SPTN5_HUMAN
NC score	0.031281 (rank : 88)	θ value	1.81305 (rank : 66)
Query Neighborhood Hits	141	Target Neighborhood Hits	674	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

RRBP1_MOUSE
NC score	0.030530 (rank : 89)	θ value	4.03905 (rank : 90)
Query Neighborhood Hits	141	Target Neighborhood Hits	1650	Shared Neighborhood Hits	57
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

CNTRB_MOUSE
NC score	0.030156 (rank : 90)	θ value	1.38821 (rank : 54)
Query Neighborhood Hits	141	Target Neighborhood Hits	1029	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

TACC2_MOUSE
NC score	0.029667 (rank : 91)	θ value	3.0926 (rank : 82)
Query Neighborhood Hits	141	Target Neighborhood Hits	774	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

ZF106_HUMAN
NC score	0.029362 (rank : 92)	θ value	1.06291 (rank : 53)
Query Neighborhood Hits	141	Target Neighborhood Hits	470	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

BLNK_MOUSE
NC score	0.029350 (rank : 93)	θ value	4.03905 (rank : 83)
Query Neighborhood Hits	141	Target Neighborhood Hits	296	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

PPRB_MOUSE
NC score	0.029266 (rank : 94)	θ value	5.27518 (rank : 102)
Query Neighborhood Hits	141	Target Neighborhood Hits	354	Shared Neighborhood Hits	23
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

RN165_HUMAN
NC score	0.029248 (rank : 95)	θ value	0.62314 (rank : 43)
Query Neighborhood Hits	141	Target Neighborhood Hits	151	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZSG1	Gene names	RNF165
Domain Architecture	No domain graphic available
Description	RING finger protein 165.

GOGA1_HUMAN
NC score	0.028679 (rank : 96)	θ value	1.81305 (rank : 62)
Query Neighborhood Hits	141	Target Neighborhood Hits	1222	Shared Neighborhood Hits	42
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

EP15R_MOUSE
NC score	0.028432 (rank : 97)	θ value	2.36792 (rank : 68)
Query Neighborhood Hits	141	Target Neighborhood Hits	1135	Shared Neighborhood Hits	48
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

WTAP_HUMAN
NC score	0.028265 (rank : 98)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	141	Target Neighborhood Hits	262	Shared Neighborhood Hits	19
SwissProt Accessions	Q15007, Q96T28, Q9BYJ7, Q9H4E2	Gene names	WTAP, KIAA0105
Domain Architecture	No domain graphic available
Description	Wilms' tumor 1-associating protein (WT1-associated protein) (Putative pre-mRNA-splicing regulator female-lethal(2D) homolog).

CYTSA_HUMAN
NC score	0.028023 (rank : 99)	θ value	0.813845 (rank : 46)
Query Neighborhood Hits	141	Target Neighborhood Hits	1138	Shared Neighborhood Hits	43
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

SYNE2_HUMAN
NC score	0.027849 (rank : 100)	θ value	5.27518 (rank : 105)
Query Neighborhood Hits	141	Target Neighborhood Hits	1323	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

CHD2_HUMAN
NC score	0.027651 (rank : 101)	θ value	0.365318 (rank : 35)
Query Neighborhood Hits	141	Target Neighborhood Hits	360	Shared Neighborhood Hits	28
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

PLEC1_HUMAN
NC score	0.027648 (rank : 102)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	141	Target Neighborhood Hits	1326	Shared Neighborhood Hits	49
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

BPAEA_HUMAN
NC score	0.027269 (rank : 103)	θ value	4.03905 (rank : 84)
Query Neighborhood Hits	141	Target Neighborhood Hits	1369	Shared Neighborhood Hits	42
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

SPTB1_MOUSE
NC score	0.027178 (rank : 104)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	141	Target Neighborhood Hits	543	Shared Neighborhood Hits	31
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SPTB2_MOUSE
NC score	0.026780 (rank : 105)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	141	Target Neighborhood Hits	770	Shared Neighborhood Hits	39
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TSC1_HUMAN
NC score	0.026774 (rank : 106)	θ value	4.03905 (rank : 95)
Query Neighborhood Hits	141	Target Neighborhood Hits	765	Shared Neighborhood Hits	36
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

ATRX_MOUSE
NC score	0.026477 (rank : 107)	θ value	6.88961 (rank : 112)
Query Neighborhood Hits	141	Target Neighborhood Hits	682	Shared Neighborhood Hits	36
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

BPAEA_MOUSE
NC score	0.026271 (rank : 108)	θ value	0.813845 (rank : 45)
Query Neighborhood Hits	141	Target Neighborhood Hits	1480	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CT2NL_HUMAN
NC score	0.026197 (rank : 109)	θ value	6.88961 (rank : 114)
Query Neighborhood Hits	141	Target Neighborhood Hits	1059	Shared Neighborhood Hits	45
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

EXTL1_MOUSE
NC score	0.025411 (rank : 110)	θ value	0.365318 (rank : 36)
Query Neighborhood Hits	141	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JKV7	Gene names	Extl1
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).

FIBA_HUMAN
NC score	0.025367 (rank : 111)	θ value	0.0961366 (rank : 29)
Query Neighborhood Hits	141	Target Neighborhood Hits	132	Shared Neighborhood Hits	5
SwissProt Accessions	P02671, Q9BX62, Q9UCH2	Gene names	FGA
Domain Architecture
Description	Fibrinogen alpha chain precursor [Contains: Fibrinopeptide A].

SELS_HUMAN
NC score	0.025346 (rank : 112)	θ value	4.03905 (rank : 91)
Query Neighborhood Hits	141	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BQE4, Q3B771, Q9P0I6	Gene names	SELS, VIMP
Domain Architecture
Description	Selenoprotein S (VCP-interacting membrane protein).

ZIMP7_HUMAN
NC score	0.024646 (rank : 113)	θ value	1.38821 (rank : 57)
Query Neighborhood Hits	141	Target Neighborhood Hits	290	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

GOGB1_HUMAN
NC score	0.024345 (rank : 114)	θ value	5.27518 (rank : 99)
Query Neighborhood Hits	141	Target Neighborhood Hits	2297	Shared Neighborhood Hits	62
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

KIF4A_MOUSE
NC score	0.024088 (rank : 115)	θ value	0.47712 (rank : 40)
Query Neighborhood Hits	141	Target Neighborhood Hits	1033	Shared Neighborhood Hits	44
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

FLNB_HUMAN
NC score	0.023677 (rank : 116)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	141	Target Neighborhood Hits	111	Shared Neighborhood Hits	11
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

LTBP3_MOUSE
NC score	0.022926 (rank : 117)	θ value	0.279714 (rank : 34)
Query Neighborhood Hits	141	Target Neighborhood Hits	475	Shared Neighborhood Hits	11
SwissProt Accessions	Q61810, Q8BNQ6	Gene names	Ltbp3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

TRIPB_HUMAN
NC score	0.022894 (rank : 118)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	141	Target Neighborhood Hits	1587	Shared Neighborhood Hits	51
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

GOGA4_MOUSE
NC score	0.022771 (rank : 119)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	141	Target Neighborhood Hits	1939	Shared Neighborhood Hits	60
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

DYNA_HUMAN
NC score	0.022308 (rank : 120)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	141	Target Neighborhood Hits	1194	Shared Neighborhood Hits	48
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

MYH3_HUMAN
NC score	0.021516 (rank : 121)	θ value	0.813845 (rank : 47)
Query Neighborhood Hits	141	Target Neighborhood Hits	1660	Shared Neighborhood Hits	49
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

SMCA2_HUMAN
NC score	0.021097 (rank : 122)	θ value	5.27518 (rank : 103)
Query Neighborhood Hits	141	Target Neighborhood Hits	503	Shared Neighborhood Hits	34
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

LTBP3_HUMAN
NC score	0.020631 (rank : 123)	θ value	0.62314 (rank : 42)
Query Neighborhood Hits	141	Target Neighborhood Hits	502	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

UT14A_HUMAN
NC score	0.019985 (rank : 124)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	141	Target Neighborhood Hits	168	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BVJ6, Q5JYF1	Gene names	UTP14A
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO- 16).

CENPJ_HUMAN
NC score	0.018998 (rank : 125)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	141	Target Neighborhood Hits	721	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

SMC1A_MOUSE
NC score	0.018794 (rank : 126)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	141	Target Neighborhood Hits	1384	Shared Neighborhood Hits	50
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SMC1A_HUMAN
NC score	0.018767 (rank : 127)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	141	Target Neighborhood Hits	1346	Shared Neighborhood Hits	48
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

MD1L1_HUMAN
NC score	0.017859 (rank : 128)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	141	Target Neighborhood Hits	893	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

CNGB3_HUMAN
NC score	0.016958 (rank : 129)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	141	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CENPE_HUMAN
NC score	0.016009 (rank : 130)	θ value	6.88961 (rank : 113)
Query Neighborhood Hits	141	Target Neighborhood Hits	2060	Shared Neighborhood Hits	51
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

HS74L_HUMAN
NC score	0.015684 (rank : 131)	θ value	1.38821 (rank : 55)
Query Neighborhood Hits	141	Target Neighborhood Hits	141	Shared Neighborhood Hits	11
SwissProt Accessions	O95757, Q4W5M5, Q8IWA2	Gene names	HSPA4L, APG1, OSP94
Domain Architecture
Description	Heat shock 70 kDa protein 4L (Osmotic stress protein 94) (Heat shock 70-related protein APG-1).

MYH13_HUMAN
NC score	0.015576 (rank : 132)	θ value	1.81305 (rank : 63)
Query Neighborhood Hits	141	Target Neighborhood Hits	1504	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

NTNG1_HUMAN
NC score	0.015379 (rank : 133)	θ value	3.0926 (rank : 78)
Query Neighborhood Hits	141	Target Neighborhood Hits	247	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2I2, Q5VU86, Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633	Gene names	NTNG1, KIAA0976, LMNT1
Domain Architecture
Description	Netrin G1 precursor (Laminet-1).

NCOA7_MOUSE
NC score	0.014936 (rank : 134)	θ value	4.03905 (rank : 88)
Query Neighborhood Hits	141	Target Neighborhood Hits	114	Shared Neighborhood Hits	7
SwissProt Accessions	Q6DFV7, Q3TAR1, Q3UNB3, Q66K05, Q6ZQM4, Q8BJ15, Q8BJ39	Gene names	Ncoa7
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 7.

PALB2_MOUSE
NC score	0.014749 (rank : 135)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	141	Target Neighborhood Hits	133	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U0P1, Q6NZG9, Q7TMQ4, Q8CEA9	Gene names	Palb2
Domain Architecture	No domain graphic available
Description	Partner and localizer of BRCA2.

ARNT_MOUSE
NC score	0.014487 (rank : 136)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	141	Target Neighborhood Hits	213	Shared Neighborhood Hits	7
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

MRE11_HUMAN
NC score	0.013451 (rank : 137)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	141	Target Neighborhood Hits	95	Shared Neighborhood Hits	5
SwissProt Accessions	P49959, O43475	Gene names	MRE11A, HNGS1, MRE11
Domain Architecture
Description	Double-strand break repair protein MRE11A (MRE11 homolog 1) (MRE11 meiotic recombination 11 homolog A).

STAB2_MOUSE
NC score	0.012821 (rank : 138)	θ value	3.0926 (rank : 81)
Query Neighborhood Hits	141	Target Neighborhood Hits	528	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

UBP35_HUMAN
NC score	0.012674 (rank : 139)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	141	Target Neighborhood Hits	223	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2H5	Gene names	USP35, KIAA1372, USP34
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.1.2.15) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35) (Deubiquitinating enzyme 35).

CACB1_HUMAN
NC score	0.012399 (rank : 140)	θ value	5.27518 (rank : 96)
Query Neighborhood Hits	141	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	Q02641, O15331, Q02639, Q02640, Q9C085	Gene names	CACNB1, CACNLB1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

CACB1_MOUSE
NC score	0.012349 (rank : 141)	θ value	5.27518 (rank : 97)
Query Neighborhood Hits	141	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R3Z5, O88517, Q7TPF2, Q8R3Z6, Q9EPT9	Gene names	Cacnb1, Cacnlb1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

RNF17_HUMAN
NC score	0.012245 (rank : 142)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	141	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BXT8, Q9BXT7	Gene names	RNF17
Domain Architecture
Description	RING finger protein 17.

SSH3_HUMAN
NC score	0.011887 (rank : 143)	θ value	5.27518 (rank : 104)
Query Neighborhood Hits	141	Target Neighborhood Hits	75	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TE77, Q6PK42, Q76I75, Q8N9L8, Q8WYL0, Q9NV45, Q9NWZ7	Gene names	SSH3, SSH3L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L).

DDX58_MOUSE
NC score	0.011772 (rank : 144)	θ value	4.03905 (rank : 85)
Query Neighborhood Hits	141	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

FOXD1_MOUSE
NC score	0.011670 (rank : 145)	θ value	0.47712 (rank : 39)
Query Neighborhood Hits	141	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	Q61345	Gene names	Foxd1, Fkhl8, Freac4, Hfhbf2
Domain Architecture
Description	Forkhead box protein D1 (Forkhead-related protein FKHL8) (Forkhead- related transcription factor 4) (FREAC-4) (Brain factor 2) (HFH-BF-2).

PITM1_HUMAN
NC score	0.011094 (rank : 146)	θ value	4.03905 (rank : 89)
Query Neighborhood Hits	141	Target Neighborhood Hits	129	Shared Neighborhood Hits	7
SwissProt Accessions	O00562, Q6T7X3, Q8TBN3, Q9BZ73	Gene names	PITPNM1, DRES9, NIR2, PITPNM
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog).

ETV4_HUMAN
NC score	0.011065 (rank : 147)	θ value	1.81305 (rank : 61)
Query Neighborhood Hits	141	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	P43268, Q96AW9	Gene names	ETV4, E1AF
Domain Architecture	No domain graphic available
Description	ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F).

PDIP3_MOUSE
NC score	0.011016 (rank : 148)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	141	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BG81, Q6PE83, Q80X99, Q8CI28	Gene names	Poldip3
Domain Architecture	No domain graphic available
Description	Polymerase delta-interacting protein 3.

NTNG1_MOUSE
NC score	0.010918 (rank : 149)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	141	Target Neighborhood Hits	246	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R4G0, Q68FE5, Q69ZU3, Q8R4F3, Q8R4F4, Q8R4F5, Q8R4F6, Q8R4F7, Q8R4F8, Q8R4F9, Q9ESR3, Q9ESR4, Q9ESR5, Q9ESR6, Q9ESR7, Q9ESR8	Gene names	Ntng1, Kiaa0976, Lmnt1
Domain Architecture
Description	Netrin G1 precursor (Laminet-1).

KRA11_HUMAN
NC score	0.010615 (rank : 150)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	141	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q07627, Q96S60, Q96S67	Gene names	KRTAP1-1, B2A, KAP1.1, KAP1.6, KAP1.7, KRTAP1.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 1-1 (Keratin-associated protein 1.1) (High sulfur keratin-associated protein 1.1) (Keratin-associated protein 1.6) (Keratin-associated protein 1.7).

JAG1_MOUSE
NC score	0.010368 (rank : 151)	θ value	5.27518 (rank : 100)
Query Neighborhood Hits	141	Target Neighborhood Hits	518	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

NFL_HUMAN
NC score	0.009678 (rank : 152)	θ value	5.27518 (rank : 101)
Query Neighborhood Hits	141	Target Neighborhood Hits	666	Shared Neighborhood Hits	33
SwissProt Accessions	P07196, Q16154, Q8IU72	Gene names	NEFL, NF68, NFL
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

VMDL3_HUMAN
NC score	0.009082 (rank : 153)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	141	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N1M1, Q8N356, Q8NFT9, Q9BR80	Gene names	VMD2L3
Domain Architecture
Description	Bestrophin-4 (Vitelliform macular dystrophy 2-like protein 3).

JAG1_HUMAN
NC score	0.008836 (rank : 154)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	141	Target Neighborhood Hits	514	Shared Neighborhood Hits	11
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

FOXO1_HUMAN
NC score	0.008580 (rank : 155)	θ value	5.27518 (rank : 98)
Query Neighborhood Hits	141	Target Neighborhood Hits	126	Shared Neighborhood Hits	3
SwissProt Accessions	Q12778, O43523, Q5VYC7, Q6NSK6	Gene names	FOXO1A, FKHR
Domain Architecture
Description	Forkhead box protein O1A (Forkhead in rhabdomyosarcoma).

TMPS2_HUMAN
NC score	0.007669 (rank : 156)	θ value	1.81305 (rank : 67)
Query Neighborhood Hits	141	Target Neighborhood Hits	252	Shared Neighborhood Hits	5
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

LRCH3_MOUSE
NC score	0.006578 (rank : 157)	θ value	3.0926 (rank : 75)
Query Neighborhood Hits	141	Target Neighborhood Hits	257	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BVU0, Q3U222, Q3UZ74	Gene names	Lrch3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 3 precursor.

SEM6B_MOUSE
NC score	0.006075 (rank : 158)	θ value	4.03905 (rank : 92)
Query Neighborhood Hits	141	Target Neighborhood Hits	200	Shared Neighborhood Hits	3
SwissProt Accessions	O54951	Gene names	Sema6b, Seman
Domain Architecture
Description	Semaphorin-6B precursor (Semaphorin VIB) (Sema VIB) (Semaphorin N) (Sema N).

ZEP1_HUMAN
NC score	0.006058 (rank : 159)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	141	Target Neighborhood Hits	1036	Shared Neighborhood Hits	21
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

CD2L7_HUMAN
NC score	0.005506 (rank : 160)	θ value	0.279714 (rank : 33)
Query Neighborhood Hits	141	Target Neighborhood Hits	1275	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

TITIN_HUMAN
NC score	0.005102 (rank : 161)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	141	Target Neighborhood Hits	2923	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

POK3_HUMAN
NC score	0.004817 (rank : 162)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	141	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WJR5, O15312	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19q12 provirus ancestral Pol protein (HERV-K(C19) Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4) (RNase H); Integrase (IN)].

PZRN4_HUMAN
NC score	0.004150 (rank : 163)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	141	Target Neighborhood Hits	438	Shared Neighborhood Hits	9
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

TMPS2_MOUSE
NC score	0.004050 (rank : 164)	θ value	4.03905 (rank : 94)
Query Neighborhood Hits	141	Target Neighborhood Hits	243	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TRI62_MOUSE
NC score	0.003985 (rank : 165)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	141	Target Neighborhood Hits	478	Shared Neighborhood Hits	17
SwissProt Accessions	Q80V85	Gene names	Trim62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

OR2J1_HUMAN
NC score	0.002424 (rank : 166)	θ value	0.47712 (rank : 41)
Query Neighborhood Hits	141	Target Neighborhood Hits	758	Shared Neighborhood Hits	4
SwissProt Accessions	Q9GZK6, Q9GZK1	Gene names	OR2J1
Domain Architecture
Description	Olfactory receptor 2J1 (Olfactory receptor 6-5) (OR6-5) (Hs6M1-4).

OR2J3_HUMAN
NC score	0.000259 (rank : 167)	θ value	3.0926 (rank : 79)
Query Neighborhood Hits	141	Target Neighborhood Hits	748	Shared Neighborhood Hits	4
SwissProt Accessions	O76001, Q96R15, Q9GZK5, Q9GZL4, Q9GZL5	Gene names	OR2J3
Domain Architecture
Description	Olfactory receptor 2J3 (Olfactory receptor 6-6) (OR6-6) (Hs6M1-3).

ZIC3_MOUSE
NC score	-0.000880 (rank : 168)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	141	Target Neighborhood Hits	713	Shared Neighborhood Hits	6
SwissProt Accessions	Q62521	Gene names	Zic3
Domain Architecture
Description	Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3).

ZIC3_HUMAN
NC score	-0.000886 (rank : 169)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	141	Target Neighborhood Hits	714	Shared Neighborhood Hits	6
SwissProt Accessions	O60481	Gene names	ZIC3
Domain Architecture
Description	Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3).

ZN335_HUMAN
NC score	-0.001216 (rank : 170)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	141	Target Neighborhood Hits	973	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H4Z2, Q9H684	Gene names	ZNF335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 335.

ZN445_HUMAN
NC score	-0.002917 (rank : 171)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	141	Target Neighborhood Hits	764	Shared Neighborhood Hits	6
SwissProt Accessions	P59923	Gene names	ZNF445, ZNF168
Domain Architecture
Description	Zinc finger protein 445.