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Network neighborhood for query Sequence : RNF17_HUMAN

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RNF17_HUMAN
SwissProt Accessions	Q9BXT8, Q9BXT7	Gene names	RNF17
Domain Architecture
Description	RING finger protein 17.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RNF17_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	71	Target Neighborhood Hits	71	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BXT8, Q9BXT7	Gene names	RNF17
Domain Architecture
Description	RING finger protein 17.

RNF17_MOUSE
θ value	0 (rank : 2)	NC score	0.901215 (rank : 2)
Query Neighborhood Hits	71	Target Neighborhood Hits	147	Shared Neighborhood Hits	19
SwissProt Accessions	Q99MV7	Gene names	Rnf17
Domain Architecture
Description	RING finger protein 17.

TDRD6_MOUSE
θ value	0.0330416 (rank : 3)	NC score	0.123552 (rank : 3)
Query Neighborhood Hits	71	Target Neighborhood Hits	82	Shared Neighborhood Hits	6
SwissProt Accessions	P61407	Gene names	Tdrd6
Domain Architecture
Description	Tudor domain-containing protein 6.

BRAP_MOUSE
θ value	0.0961366 (rank : 4)	NC score	0.074179 (rank : 10)
Query Neighborhood Hits	71	Target Neighborhood Hits	409	Shared Neighborhood Hits	19
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

ZN668_MOUSE
θ value	0.21417 (rank : 5)	NC score	0.007871 (rank : 68)
Query Neighborhood Hits	71	Target Neighborhood Hits	763	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2R5, Q3TEM2, Q3U7Y5, Q8C8B7	Gene names	Znf668, Zfp668
Domain Architecture	No domain graphic available
Description	Zinc finger protein 668.

MBB1A_MOUSE
θ value	0.279714 (rank : 6)	NC score	0.052877 (rank : 16)
Query Neighborhood Hits	71	Target Neighborhood Hits	233	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TPV4, O35851, Q80Y66, Q8R4X2, Q99KP0	Gene names	Mybbp1a, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A (Myb-binding protein of 160 kDa).

ZN668_HUMAN
θ value	0.279714 (rank : 7)	NC score	0.007680 (rank : 69)
Query Neighborhood Hits	71	Target Neighborhood Hits	761	Shared Neighborhood Hits	4
SwissProt Accessions	Q96K58, Q59EV1, Q8N669, Q9H8L4	Gene names	ZNF668
Domain Architecture	No domain graphic available
Description	Zinc finger protein 668.

BFAR_HUMAN
θ value	0.365318 (rank : 8)	NC score	0.082823 (rank : 5)
Query Neighborhood Hits	71	Target Neighborhood Hits	222	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

BFAR_MOUSE
θ value	0.365318 (rank : 9)	NC score	0.081907 (rank : 6)
Query Neighborhood Hits	71	Target Neighborhood Hits	232	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

TRI13_MOUSE
θ value	0.365318 (rank : 10)	NC score	0.076820 (rank : 7)
Query Neighborhood Hits	71	Target Neighborhood Hits	282	Shared Neighborhood Hits	25
SwissProt Accessions	Q9CYB0, Q8CEV0, Q923J0, Q925P1, Q99PQ0	Gene names	Trim13, Rfp2
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2).

CI093_HUMAN
θ value	0.47712 (rank : 11)	NC score	0.026321 (rank : 43)
Query Neighborhood Hits	71	Target Neighborhood Hits	1088	Shared Neighborhood Hits	24
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

IFT81_HUMAN
θ value	0.47712 (rank : 12)	NC score	0.037391 (rank : 32)
Query Neighborhood Hits	71	Target Neighborhood Hits	893	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

RN168_MOUSE
θ value	0.47712 (rank : 13)	NC score	0.065627 (rank : 11)
Query Neighborhood Hits	71	Target Neighborhood Hits	440	Shared Neighborhood Hits	28
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

SND1_MOUSE
θ value	0.62314 (rank : 14)	NC score	0.074589 (rank : 9)
Query Neighborhood Hits	71	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q78PY7, Q3TT46, Q922L5, Q9R0S1	Gene names	Snd1
Domain Architecture	No domain graphic available
Description	Staphylococcal nuclease domain-containing protein 1 (p100 co- activator) (100 kDa coactivator).

NHLC1_HUMAN
θ value	0.813845 (rank : 15)	NC score	0.062321 (rank : 12)
Query Neighborhood Hits	71	Target Neighborhood Hits	91	Shared Neighborhood Hits	12
SwissProt Accessions	Q6VVB1, Q6IMH1	Gene names	NHLRC1, EPM2B
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

RN125_HUMAN
θ value	0.813845 (rank : 16)	NC score	0.054982 (rank : 14)
Query Neighborhood Hits	71	Target Neighborhood Hits	230	Shared Neighborhood Hits	22
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

SND1_HUMAN
θ value	0.813845 (rank : 17)	NC score	0.083236 (rank : 4)
Query Neighborhood Hits	71	Target Neighborhood Hits	25	Shared Neighborhood Hits	6
SwissProt Accessions	Q7KZF4, Q13122	Gene names	SND1
Domain Architecture	No domain graphic available
Description	Staphylococcal nuclease domain-containing protein 1 (p100 co- activator) (100 kDa coactivator) (EBNA2 coactivator p100).

TRI13_HUMAN
θ value	0.813845 (rank : 18)	NC score	0.076241 (rank : 8)
Query Neighborhood Hits	71	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	O60858, Q9BQ47, Q9C021	Gene names	TRIM13, LEU5, RFP2, RNF77
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2) (Leukemia-associated protein 5) (B- cell chronic lymphocytic leukemia tumor suppressor Leu5) (RING finger protein 77).

BRAP_HUMAN
θ value	1.06291 (rank : 19)	NC score	0.058008 (rank : 13)
Query Neighborhood Hits	71	Target Neighborhood Hits	560	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

DESP_HUMAN
θ value	1.06291 (rank : 20)	NC score	0.021141 (rank : 54)
Query Neighborhood Hits	71	Target Neighborhood Hits	1470	Shared Neighborhood Hits	26
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

SIVA_HUMAN
θ value	1.06291 (rank : 21)	NC score	0.054330 (rank : 15)
Query Neighborhood Hits	71	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	O15304, Q96P98, Q9UPD6	Gene names	SIVA
Domain Architecture
Description	Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP).

RINT1_MOUSE
θ value	1.38821 (rank : 22)	NC score	0.038214 (rank : 31)
Query Neighborhood Hits	71	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BZ36, Q3UXS1, Q6P1I2, Q8C193	Gene names	Rint1
Domain Architecture	No domain graphic available
Description	RAD50-interacting protein 1 (RAD50 interactor 1) (Protein RINT-1).

VINC_HUMAN
θ value	1.38821 (rank : 23)	NC score	0.047139 (rank : 21)
Query Neighborhood Hits	71	Target Neighborhood Hits	145	Shared Neighborhood Hits	5
SwissProt Accessions	P18206, Q16450, Q5SWX2, Q7Z3B8, Q8IXU7	Gene names	VCL
Domain Architecture
Description	Vinculin (Metavinculin).

VINC_MOUSE
θ value	1.38821 (rank : 24)	NC score	0.043890 (rank : 28)
Query Neighborhood Hits	71	Target Neighborhood Hits	135	Shared Neighborhood Hits	5
SwissProt Accessions	Q64727, Q8BP32, Q8BS46, Q922C5, Q922D9	Gene names	Vcl
Domain Architecture
Description	Vinculin (Metavinculin).

PHLB2_HUMAN
θ value	2.36792 (rank : 25)	NC score	0.028651 (rank : 38)
Query Neighborhood Hits	71	Target Neighborhood Hits	964	Shared Neighborhood Hits	26
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

TRI39_MOUSE
θ value	2.36792 (rank : 26)	NC score	0.045390 (rank : 26)
Query Neighborhood Hits	71	Target Neighborhood Hits	691	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI42_HUMAN
θ value	2.36792 (rank : 27)	NC score	0.040092 (rank : 29)
Query Neighborhood Hits	71	Target Neighborhood Hits	283	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

EMIL2_HUMAN
θ value	3.0926 (rank : 28)	NC score	0.023745 (rank : 50)
Query Neighborhood Hits	71	Target Neighborhood Hits	573	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BXX0, Q8NBH3, Q96JQ4	Gene names	EMILIN2
Domain Architecture
Description	EMILIN-2 precursor (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10).

PGK1_HUMAN
θ value	3.0926 (rank : 29)	NC score	0.029397 (rank : 37)
Query Neighborhood Hits	71	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P00558, Q6IBT6, Q8NI87	Gene names	PGK1, PGKA
Domain Architecture
Description	Phosphoglycerate kinase 1 (EC 2.7.2.3) (Primer recognition protein 2) (PRP 2).

TRAF5_HUMAN
θ value	3.0926 (rank : 30)	NC score	0.025999 (rank : 44)
Query Neighborhood Hits	71	Target Neighborhood Hits	396	Shared Neighborhood Hits	21
SwissProt Accessions	O00463	Gene names	TRAF5, RNF84
Domain Architecture
Description	TNF receptor-associated factor 5 (RING finger protein 84).

TRI60_MOUSE
θ value	3.0926 (rank : 31)	NC score	0.032785 (rank : 35)
Query Neighborhood Hits	71	Target Neighborhood Hits	240	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VI40, Q3UX74	Gene names	Trim60, 2czf45, Rnf33
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (Ring finger protein 33).

TRIM2_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.047026 (rank : 22)
Query Neighborhood Hits	71	Target Neighborhood Hits	330	Shared Neighborhood Hits	24
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

CARD6_HUMAN
θ value	4.03905 (rank : 33)	NC score	0.030022 (rank : 36)
Query Neighborhood Hits	71	Target Neighborhood Hits	145	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BX69	Gene names	CARD6
Domain Architecture
Description	Caspase recruitment domain-containing protein 6.

CK5P2_MOUSE
θ value	4.03905 (rank : 34)	NC score	0.018856 (rank : 59)
Query Neighborhood Hits	71	Target Neighborhood Hits	1151	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

CSKP_HUMAN
θ value	4.03905 (rank : 35)	NC score	0.003626 (rank : 72)
Query Neighborhood Hits	71	Target Neighborhood Hits	1022	Shared Neighborhood Hits	4
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	4.03905 (rank : 36)	NC score	0.003642 (rank : 71)
Query Neighborhood Hits	71	Target Neighborhood Hits	1027	Shared Neighborhood Hits	4
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

TRIM3_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.045502 (rank : 25)
Query Neighborhood Hits	71	Target Neighborhood Hits	357	Shared Neighborhood Hits	27
SwissProt Accessions	O75382, Q9C038, Q9C039	Gene names	TRIM3, BERP, RNF22, RNF97
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (Brain- expressed RING finger protein) (RING finger protein 97).

TRIM3_MOUSE
θ value	4.03905 (rank : 38)	NC score	0.045261 (rank : 27)
Query Neighborhood Hits	71	Target Neighborhood Hits	351	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1R2, Q3UMU5	Gene names	Trim3, Hac1, Rnf22
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1).

ZNF70_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.003825 (rank : 70)
Query Neighborhood Hits	71	Target Neighborhood Hits	760	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UC06	Gene names	ZNF70
Domain Architecture	No domain graphic available
Description	Zinc finger protein 70 (Zinc finger protein N27C7-1).

CSRP2_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.015978 (rank : 60)
Query Neighborhood Hits	71	Target Neighborhood Hits	150	Shared Neighborhood Hits	3
SwissProt Accessions	Q16527, Q93030	Gene names	CSRP2, LMO5, SMLIM
Domain Architecture
Description	Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) (Smooth muscle cell LIM protein) (SmLIM) (LIM-only protein 5).

CSRP2_MOUSE
θ value	5.27518 (rank : 41)	NC score	0.015971 (rank : 61)
Query Neighborhood Hits	71	Target Neighborhood Hits	152	Shared Neighborhood Hits	3
SwissProt Accessions	P97314, Q9CZG5	Gene names	Csrp2, Dlp1
Domain Architecture
Description	Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) (Double LIM protein 1) (DLP-1).

PHLB2_MOUSE
θ value	5.27518 (rank : 42)	NC score	0.025867 (rank : 45)
Query Neighborhood Hits	71	Target Neighborhood Hits	1016	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

TRI25_HUMAN
θ value	5.27518 (rank : 43)	NC score	0.038554 (rank : 30)
Query Neighborhood Hits	71	Target Neighborhood Hits	472	Shared Neighborhood Hits	33
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

TRI43_HUMAN
θ value	5.27518 (rank : 44)	NC score	0.032801 (rank : 34)
Query Neighborhood Hits	71	Target Neighborhood Hits	341	Shared Neighborhood Hits	25
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

WAPL_HUMAN
θ value	5.27518 (rank : 45)	NC score	0.021206 (rank : 53)
Query Neighborhood Hits	71	Target Neighborhood Hits	122	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z5K2, Q5VSK5, Q8IX10, Q92549	Gene names	WAPAL, FOE, KIAA0261, WAPL
Domain Architecture	No domain graphic available
Description	Wings apart-like protein homolog (Friend of EBNA2 protein).

ATOH1_MOUSE
θ value	6.88961 (rank : 46)	NC score	0.013189 (rank : 64)
Query Neighborhood Hits	71	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	P48985	Gene names	Atoh1, Ath1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein mATH-1) (MATH1).

CCD46_HUMAN
θ value	6.88961 (rank : 47)	NC score	0.018875 (rank : 58)
Query Neighborhood Hits	71	Target Neighborhood Hits	1430	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

GCC2_HUMAN
θ value	6.88961 (rank : 48)	NC score	0.021891 (rank : 51)
Query Neighborhood Hits	71	Target Neighborhood Hits	1558	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

GOSR2_MOUSE
θ value	6.88961 (rank : 49)	NC score	0.024933 (rank : 48)
Query Neighborhood Hits	71	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	O35166, Q3UDN0, Q9CR77	Gene names	Gosr2, Gs27
Domain Architecture
Description	Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin).

MLL2_HUMAN
θ value	6.88961 (rank : 50)	NC score	0.012636 (rank : 66)
Query Neighborhood Hits	71	Target Neighborhood Hits	1788	Shared Neighborhood Hits	28
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

OGT1_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.012879 (rank : 65)
Query Neighborhood Hits	71	Target Neighborhood Hits	143	Shared Neighborhood Hits	2
SwissProt Accessions	O15294, Q7Z3K0, Q8WWM8, Q96CC1, Q9UG57	Gene names	OGT
Domain Architecture
Description	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.-) (O-GlcNAc transferase p110 subunit).

PGK1_MOUSE
θ value	6.88961 (rank : 52)	NC score	0.025203 (rank : 47)
Query Neighborhood Hits	71	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P09411	Gene names	Pgk1, Pgk-1
Domain Architecture
Description	Phosphoglycerate kinase 1 (EC 2.7.2.3).

RAD50_HUMAN
θ value	6.88961 (rank : 53)	NC score	0.028536 (rank : 39)
Query Neighborhood Hits	71	Target Neighborhood Hits	1317	Shared Neighborhood Hits	26
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RBNS5_HUMAN
θ value	6.88961 (rank : 54)	NC score	0.052616 (rank : 17)
Query Neighborhood Hits	71	Target Neighborhood Hits	242	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	6.88961 (rank : 55)	NC score	0.046813 (rank : 24)
Query Neighborhood Hits	71	Target Neighborhood Hits	266	Shared Neighborhood Hits	15
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

RBP24_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.021849 (rank : 52)
Query Neighborhood Hits	71	Target Neighborhood Hits	1559	Shared Neighborhood Hits	38
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

RO52_HUMAN
θ value	6.88961 (rank : 57)	NC score	0.028049 (rank : 41)
Query Neighborhood Hits	71	Target Neighborhood Hits	419	Shared Neighborhood Hits	30
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

STK31_HUMAN
θ value	6.88961 (rank : 58)	NC score	0.026329 (rank : 42)
Query Neighborhood Hits	71	Target Neighborhood Hits	570	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

TMCC1_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.020378 (rank : 56)
Query Neighborhood Hits	71	Target Neighborhood Hits	337	Shared Neighborhood Hits	14
SwissProt Accessions	O94876, Q68E06, Q8IXM8	Gene names	TMCC1, KIAA0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

TMCC1_MOUSE
θ value	6.88961 (rank : 60)	NC score	0.020400 (rank : 55)
Query Neighborhood Hits	71	Target Neighborhood Hits	315	Shared Neighborhood Hits	13
SwissProt Accessions	Q69ZZ6, Q8CEF4	Gene names	Tmcc1, Kiaa0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

TPP1_MOUSE
θ value	6.88961 (rank : 61)	NC score	0.019544 (rank : 57)
Query Neighborhood Hits	71	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	O89023, Q543Q8, Q9QUS7	Gene names	Tpp1, Cln2
Domain Architecture
Description	Tripeptidyl-peptidase 1 precursor (EC 3.4.14.9) (Tripeptidyl-peptidase I) (TPP-I) (Tripeptidyl aminopeptidase) (Lysosomal pepstatin insensitive protease) (LPIC).

TRI32_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.048325 (rank : 20)
Query Neighborhood Hits	71	Target Neighborhood Hits	264	Shared Neighborhood Hits	25
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI32_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.048794 (rank : 19)
Query Neighborhood Hits	71	Target Neighborhood Hits	271	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

BIG1_HUMAN
θ value	8.99809 (rank : 64)	NC score	0.015245 (rank : 63)
Query Neighborhood Hits	71	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

CCD41_HUMAN
θ value	8.99809 (rank : 65)	NC score	0.015300 (rank : 62)
Query Neighborhood Hits	71	Target Neighborhood Hits	1139	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

IFT81_MOUSE
θ value	8.99809 (rank : 66)	NC score	0.024014 (rank : 49)
Query Neighborhood Hits	71	Target Neighborhood Hits	959	Shared Neighborhood Hits	21
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

RUFY1_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.025659 (rank : 46)
Query Neighborhood Hits	71	Target Neighborhood Hits	848	Shared Neighborhood Hits	27
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

SETB1_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.012245 (rank : 67)
Query Neighborhood Hits	71	Target Neighborhood Hits	141	Shared Neighborhood Hits	3
SwissProt Accessions	Q15047, Q96GM9	Gene names	SETDB1, KIAA0067
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

TRI39_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.046955 (rank : 23)
Query Neighborhood Hits	71	Target Neighborhood Hits	693	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI42_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.035098 (rank : 33)
Query Neighborhood Hits	71	Target Neighborhood Hits	316	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

TRIM1_MOUSE
θ value	8.99809 (rank : 71)	NC score	0.028469 (rank : 40)
Query Neighborhood Hits	71	Target Neighborhood Hits	361	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QUS6	Gene names	Mid2, Fxy2, Trim1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1).

TDRD5_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.050016 (rank : 18)
Query Neighborhood Hits	71	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NAT2, Q5VTV0	Gene names	TDRD5
Domain Architecture
Description	Tudor domain-containing protein 5.

Hits sorted by NC score

RNF17_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	71	Target Neighborhood Hits	71	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BXT8, Q9BXT7	Gene names	RNF17
Domain Architecture
Description	RING finger protein 17.

RNF17_MOUSE
NC score	0.901215 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	71	Target Neighborhood Hits	147	Shared Neighborhood Hits	19
SwissProt Accessions	Q99MV7	Gene names	Rnf17
Domain Architecture
Description	RING finger protein 17.

TDRD6_MOUSE
NC score	0.123552 (rank : 3)	θ value	0.0330416 (rank : 3)
Query Neighborhood Hits	71	Target Neighborhood Hits	82	Shared Neighborhood Hits	6
SwissProt Accessions	P61407	Gene names	Tdrd6
Domain Architecture
Description	Tudor domain-containing protein 6.

SND1_HUMAN
NC score	0.083236 (rank : 4)	θ value	0.813845 (rank : 17)
Query Neighborhood Hits	71	Target Neighborhood Hits	25	Shared Neighborhood Hits	6
SwissProt Accessions	Q7KZF4, Q13122	Gene names	SND1
Domain Architecture	No domain graphic available
Description	Staphylococcal nuclease domain-containing protein 1 (p100 co- activator) (100 kDa coactivator) (EBNA2 coactivator p100).

BFAR_HUMAN
NC score	0.082823 (rank : 5)	θ value	0.365318 (rank : 8)
Query Neighborhood Hits	71	Target Neighborhood Hits	222	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

BFAR_MOUSE
NC score	0.081907 (rank : 6)	θ value	0.365318 (rank : 9)
Query Neighborhood Hits	71	Target Neighborhood Hits	232	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

TRI13_MOUSE
NC score	0.076820 (rank : 7)	θ value	0.365318 (rank : 10)
Query Neighborhood Hits	71	Target Neighborhood Hits	282	Shared Neighborhood Hits	25
SwissProt Accessions	Q9CYB0, Q8CEV0, Q923J0, Q925P1, Q99PQ0	Gene names	Trim13, Rfp2
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2).

TRI13_HUMAN
NC score	0.076241 (rank : 8)	θ value	0.813845 (rank : 18)
Query Neighborhood Hits	71	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	O60858, Q9BQ47, Q9C021	Gene names	TRIM13, LEU5, RFP2, RNF77
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2) (Leukemia-associated protein 5) (B- cell chronic lymphocytic leukemia tumor suppressor Leu5) (RING finger protein 77).

SND1_MOUSE
NC score	0.074589 (rank : 9)	θ value	0.62314 (rank : 14)
Query Neighborhood Hits	71	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q78PY7, Q3TT46, Q922L5, Q9R0S1	Gene names	Snd1
Domain Architecture	No domain graphic available
Description	Staphylococcal nuclease domain-containing protein 1 (p100 co- activator) (100 kDa coactivator).

BRAP_MOUSE
NC score	0.074179 (rank : 10)	θ value	0.0961366 (rank : 4)
Query Neighborhood Hits	71	Target Neighborhood Hits	409	Shared Neighborhood Hits	19
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

RN168_MOUSE
NC score	0.065627 (rank : 11)	θ value	0.47712 (rank : 13)
Query Neighborhood Hits	71	Target Neighborhood Hits	440	Shared Neighborhood Hits	28
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

NHLC1_HUMAN
NC score	0.062321 (rank : 12)	θ value	0.813845 (rank : 15)
Query Neighborhood Hits	71	Target Neighborhood Hits	91	Shared Neighborhood Hits	12
SwissProt Accessions	Q6VVB1, Q6IMH1	Gene names	NHLRC1, EPM2B
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

BRAP_HUMAN
NC score	0.058008 (rank : 13)	θ value	1.06291 (rank : 19)
Query Neighborhood Hits	71	Target Neighborhood Hits	560	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

RN125_HUMAN
NC score	0.054982 (rank : 14)	θ value	0.813845 (rank : 16)
Query Neighborhood Hits	71	Target Neighborhood Hits	230	Shared Neighborhood Hits	22
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

SIVA_HUMAN
NC score	0.054330 (rank : 15)	θ value	1.06291 (rank : 21)
Query Neighborhood Hits	71	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	O15304, Q96P98, Q9UPD6	Gene names	SIVA
Domain Architecture
Description	Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP).

MBB1A_MOUSE
NC score	0.052877 (rank : 16)	θ value	0.279714 (rank : 6)
Query Neighborhood Hits	71	Target Neighborhood Hits	233	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TPV4, O35851, Q80Y66, Q8R4X2, Q99KP0	Gene names	Mybbp1a, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A (Myb-binding protein of 160 kDa).

RBNS5_HUMAN
NC score	0.052616 (rank : 17)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	71	Target Neighborhood Hits	242	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

TDRD5_HUMAN
NC score	0.050016 (rank : 18)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	71	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NAT2, Q5VTV0	Gene names	TDRD5
Domain Architecture
Description	Tudor domain-containing protein 5.

TRI32_MOUSE
NC score	0.048794 (rank : 19)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	71	Target Neighborhood Hits	271	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

TRI32_HUMAN
NC score	0.048325 (rank : 20)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	71	Target Neighborhood Hits	264	Shared Neighborhood Hits	25
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

VINC_HUMAN
NC score	0.047139 (rank : 21)	θ value	1.38821 (rank : 23)
Query Neighborhood Hits	71	Target Neighborhood Hits	145	Shared Neighborhood Hits	5
SwissProt Accessions	P18206, Q16450, Q5SWX2, Q7Z3B8, Q8IXU7	Gene names	VCL
Domain Architecture
Description	Vinculin (Metavinculin).

TRIM2_HUMAN
NC score	0.047026 (rank : 22)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	71	Target Neighborhood Hits	330	Shared Neighborhood Hits	24
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

TRI39_HUMAN
NC score	0.046955 (rank : 23)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	71	Target Neighborhood Hits	693	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

RBNS5_MOUSE
NC score	0.046813 (rank : 24)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	71	Target Neighborhood Hits	266	Shared Neighborhood Hits	15
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

TRIM3_HUMAN
NC score	0.045502 (rank : 25)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	71	Target Neighborhood Hits	357	Shared Neighborhood Hits	27
SwissProt Accessions	O75382, Q9C038, Q9C039	Gene names	TRIM3, BERP, RNF22, RNF97
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (Brain- expressed RING finger protein) (RING finger protein 97).

TRI39_MOUSE
NC score	0.045390 (rank : 26)	θ value	2.36792 (rank : 26)
Query Neighborhood Hits	71	Target Neighborhood Hits	691	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRIM3_MOUSE
NC score	0.045261 (rank : 27)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	71	Target Neighborhood Hits	351	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1R2, Q3UMU5	Gene names	Trim3, Hac1, Rnf22
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1).

VINC_MOUSE
NC score	0.043890 (rank : 28)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	71	Target Neighborhood Hits	135	Shared Neighborhood Hits	5
SwissProt Accessions	Q64727, Q8BP32, Q8BS46, Q922C5, Q922D9	Gene names	Vcl
Domain Architecture
Description	Vinculin (Metavinculin).

TRI42_HUMAN
NC score	0.040092 (rank : 29)	θ value	2.36792 (rank : 27)
Query Neighborhood Hits	71	Target Neighborhood Hits	283	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

TRI25_HUMAN
NC score	0.038554 (rank : 30)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	71	Target Neighborhood Hits	472	Shared Neighborhood Hits	33
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

RINT1_MOUSE
NC score	0.038214 (rank : 31)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	71	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BZ36, Q3UXS1, Q6P1I2, Q8C193	Gene names	Rint1
Domain Architecture	No domain graphic available
Description	RAD50-interacting protein 1 (RAD50 interactor 1) (Protein RINT-1).

IFT81_HUMAN
NC score	0.037391 (rank : 32)	θ value	0.47712 (rank : 12)
Query Neighborhood Hits	71	Target Neighborhood Hits	893	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

TRI42_MOUSE
NC score	0.035098 (rank : 33)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	71	Target Neighborhood Hits	316	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

TRI43_HUMAN
NC score	0.032801 (rank : 34)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	71	Target Neighborhood Hits	341	Shared Neighborhood Hits	25
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

TRI60_MOUSE
NC score	0.032785 (rank : 35)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	71	Target Neighborhood Hits	240	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VI40, Q3UX74	Gene names	Trim60, 2czf45, Rnf33
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (Ring finger protein 33).

CARD6_HUMAN
NC score	0.030022 (rank : 36)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	71	Target Neighborhood Hits	145	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BX69	Gene names	CARD6
Domain Architecture
Description	Caspase recruitment domain-containing protein 6.

PGK1_HUMAN
NC score	0.029397 (rank : 37)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	71	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P00558, Q6IBT6, Q8NI87	Gene names	PGK1, PGKA
Domain Architecture
Description	Phosphoglycerate kinase 1 (EC 2.7.2.3) (Primer recognition protein 2) (PRP 2).

PHLB2_HUMAN
NC score	0.028651 (rank : 38)	θ value	2.36792 (rank : 25)
Query Neighborhood Hits	71	Target Neighborhood Hits	964	Shared Neighborhood Hits	26
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

RAD50_HUMAN
NC score	0.028536 (rank : 39)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	71	Target Neighborhood Hits	1317	Shared Neighborhood Hits	26
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

TRIM1_MOUSE
NC score	0.028469 (rank : 40)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	71	Target Neighborhood Hits	361	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QUS6	Gene names	Mid2, Fxy2, Trim1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1).

RO52_HUMAN
NC score	0.028049 (rank : 41)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	71	Target Neighborhood Hits	419	Shared Neighborhood Hits	30
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

STK31_HUMAN
NC score	0.026329 (rank : 42)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	71	Target Neighborhood Hits	570	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

CI093_HUMAN
NC score	0.026321 (rank : 43)	θ value	0.47712 (rank : 11)
Query Neighborhood Hits	71	Target Neighborhood Hits	1088	Shared Neighborhood Hits	24
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

TRAF5_HUMAN
NC score	0.025999 (rank : 44)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	71	Target Neighborhood Hits	396	Shared Neighborhood Hits	21
SwissProt Accessions	O00463	Gene names	TRAF5, RNF84
Domain Architecture
Description	TNF receptor-associated factor 5 (RING finger protein 84).

PHLB2_MOUSE
NC score	0.025867 (rank : 45)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	71	Target Neighborhood Hits	1016	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

RUFY1_HUMAN
NC score	0.025659 (rank : 46)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	71	Target Neighborhood Hits	848	Shared Neighborhood Hits	27
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

PGK1_MOUSE
NC score	0.025203 (rank : 47)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	71	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P09411	Gene names	Pgk1, Pgk-1
Domain Architecture
Description	Phosphoglycerate kinase 1 (EC 2.7.2.3).

GOSR2_MOUSE
NC score	0.024933 (rank : 48)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	71	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	O35166, Q3UDN0, Q9CR77	Gene names	Gosr2, Gs27
Domain Architecture
Description	Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin).

IFT81_MOUSE
NC score	0.024014 (rank : 49)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	71	Target Neighborhood Hits	959	Shared Neighborhood Hits	21
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

EMIL2_HUMAN
NC score	0.023745 (rank : 50)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	71	Target Neighborhood Hits	573	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BXX0, Q8NBH3, Q96JQ4	Gene names	EMILIN2
Domain Architecture
Description	EMILIN-2 precursor (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10).

GCC2_HUMAN
NC score	0.021891 (rank : 51)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	71	Target Neighborhood Hits	1558	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

RBP24_HUMAN
NC score	0.021849 (rank : 52)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	71	Target Neighborhood Hits	1559	Shared Neighborhood Hits	38
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

WAPL_HUMAN
NC score	0.021206 (rank : 53)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	71	Target Neighborhood Hits	122	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z5K2, Q5VSK5, Q8IX10, Q92549	Gene names	WAPAL, FOE, KIAA0261, WAPL
Domain Architecture	No domain graphic available
Description	Wings apart-like protein homolog (Friend of EBNA2 protein).

DESP_HUMAN
NC score	0.021141 (rank : 54)	θ value	1.06291 (rank : 20)
Query Neighborhood Hits	71	Target Neighborhood Hits	1470	Shared Neighborhood Hits	26
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

TMCC1_MOUSE
NC score	0.020400 (rank : 55)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	71	Target Neighborhood Hits	315	Shared Neighborhood Hits	13
SwissProt Accessions	Q69ZZ6, Q8CEF4	Gene names	Tmcc1, Kiaa0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

TMCC1_HUMAN
NC score	0.020378 (rank : 56)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	71	Target Neighborhood Hits	337	Shared Neighborhood Hits	14
SwissProt Accessions	O94876, Q68E06, Q8IXM8	Gene names	TMCC1, KIAA0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

TPP1_MOUSE
NC score	0.019544 (rank : 57)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	71	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	O89023, Q543Q8, Q9QUS7	Gene names	Tpp1, Cln2
Domain Architecture
Description	Tripeptidyl-peptidase 1 precursor (EC 3.4.14.9) (Tripeptidyl-peptidase I) (TPP-I) (Tripeptidyl aminopeptidase) (Lysosomal pepstatin insensitive protease) (LPIC).

CCD46_HUMAN
NC score	0.018875 (rank : 58)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	71	Target Neighborhood Hits	1430	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CK5P2_MOUSE
NC score	0.018856 (rank : 59)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	71	Target Neighborhood Hits	1151	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

CSRP2_HUMAN
NC score	0.015978 (rank : 60)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	71	Target Neighborhood Hits	150	Shared Neighborhood Hits	3
SwissProt Accessions	Q16527, Q93030	Gene names	CSRP2, LMO5, SMLIM
Domain Architecture
Description	Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) (Smooth muscle cell LIM protein) (SmLIM) (LIM-only protein 5).

CSRP2_MOUSE
NC score	0.015971 (rank : 61)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	71	Target Neighborhood Hits	152	Shared Neighborhood Hits	3
SwissProt Accessions	P97314, Q9CZG5	Gene names	Csrp2, Dlp1
Domain Architecture
Description	Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) (Double LIM protein 1) (DLP-1).

CCD41_HUMAN
NC score	0.015300 (rank : 62)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	71	Target Neighborhood Hits	1139	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

BIG1_HUMAN
NC score	0.015245 (rank : 63)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	71	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

ATOH1_MOUSE
NC score	0.013189 (rank : 64)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	71	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	P48985	Gene names	Atoh1, Ath1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein mATH-1) (MATH1).

OGT1_HUMAN
NC score	0.012879 (rank : 65)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	71	Target Neighborhood Hits	143	Shared Neighborhood Hits	2
SwissProt Accessions	O15294, Q7Z3K0, Q8WWM8, Q96CC1, Q9UG57	Gene names	OGT
Domain Architecture
Description	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.-) (O-GlcNAc transferase p110 subunit).

MLL2_HUMAN
NC score	0.012636 (rank : 66)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	71	Target Neighborhood Hits	1788	Shared Neighborhood Hits	28
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

SETB1_HUMAN
NC score	0.012245 (rank : 67)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	71	Target Neighborhood Hits	141	Shared Neighborhood Hits	3
SwissProt Accessions	Q15047, Q96GM9	Gene names	SETDB1, KIAA0067
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

ZN668_MOUSE
NC score	0.007871 (rank : 68)	θ value	0.21417 (rank : 5)
Query Neighborhood Hits	71	Target Neighborhood Hits	763	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2R5, Q3TEM2, Q3U7Y5, Q8C8B7	Gene names	Znf668, Zfp668
Domain Architecture	No domain graphic available
Description	Zinc finger protein 668.

ZN668_HUMAN
NC score	0.007680 (rank : 69)	θ value	0.279714 (rank : 7)
Query Neighborhood Hits	71	Target Neighborhood Hits	761	Shared Neighborhood Hits	4
SwissProt Accessions	Q96K58, Q59EV1, Q8N669, Q9H8L4	Gene names	ZNF668
Domain Architecture	No domain graphic available
Description	Zinc finger protein 668.

ZNF70_HUMAN
NC score	0.003825 (rank : 70)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	71	Target Neighborhood Hits	760	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UC06	Gene names	ZNF70
Domain Architecture	No domain graphic available
Description	Zinc finger protein 70 (Zinc finger protein N27C7-1).

CSKP_MOUSE
NC score	0.003642 (rank : 71)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	71	Target Neighborhood Hits	1027	Shared Neighborhood Hits	4
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CSKP_HUMAN
NC score	0.003626 (rank : 72)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	71	Target Neighborhood Hits	1022	Shared Neighborhood Hits	4
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).