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Network neighborhood for query Sequence : BIG1_HUMAN

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BIG1_HUMAN
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

BIG1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BIG2_HUMAN
θ value	0 (rank : 2)	NC score	0.992959 (rank : 2)
Query Neighborhood Hits	76	Target Neighborhood Hits	66	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

GBF1_HUMAN
θ value	3.59435e-57 (rank : 3)	NC score	0.869742 (rank : 3)
Query Neighborhood Hits	76	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

CYH1_MOUSE
θ value	8.57503e-51 (rank : 4)	NC score	0.823544 (rank : 8)
Query Neighborhood Hits	76	Target Neighborhood Hits	176	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH1_HUMAN
θ value	1.11993e-50 (rank : 5)	NC score	0.821107 (rank : 11)
Query Neighborhood Hits	76	Target Neighborhood Hits	184	Shared Neighborhood Hits	22
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH3_HUMAN
θ value	4.70527e-49 (rank : 6)	NC score	0.824502 (rank : 6)
Query Neighborhood Hits	76	Target Neighborhood Hits	137	Shared Neighborhood Hits	23
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH3_MOUSE
θ value	8.02596e-49 (rank : 7)	NC score	0.818605 (rank : 13)
Query Neighborhood Hits	76	Target Neighborhood Hits	148	Shared Neighborhood Hits	23
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH2_HUMAN
θ value	2.58187e-47 (rank : 8)	NC score	0.824890 (rank : 5)
Query Neighborhood Hits	76	Target Neighborhood Hits	175	Shared Neighborhood Hits	24
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	4.40402e-47 (rank : 9)	NC score	0.824918 (rank : 4)
Query Neighborhood Hits	76	Target Neighborhood Hits	171	Shared Neighborhood Hits	24
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH4_MOUSE
θ value	1.28137e-46 (rank : 10)	NC score	0.823648 (rank : 7)
Query Neighborhood Hits	76	Target Neighborhood Hits	134	Shared Neighborhood Hits	22
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH4_HUMAN
θ value	4.122e-45 (rank : 11)	NC score	0.822585 (rank : 10)
Query Neighborhood Hits	76	Target Neighborhood Hits	135	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

IQEC1_MOUSE
θ value	4.41421e-39 (rank : 12)	NC score	0.820386 (rank : 12)
Query Neighborhood Hits	76	Target Neighborhood Hits	54	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

IQEC1_HUMAN
θ value	5.76516e-39 (rank : 13)	NC score	0.817990 (rank : 14)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	25
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC2_MOUSE
θ value	1.6774e-38 (rank : 14)	NC score	0.774822 (rank : 18)
Query Neighborhood Hits	76	Target Neighborhood Hits	417	Shared Neighborhood Hits	26
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_HUMAN
θ value	2.19075e-38 (rank : 15)	NC score	0.775007 (rank : 17)
Query Neighborhood Hits	76	Target Neighborhood Hits	403	Shared Neighborhood Hits	26
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC3_HUMAN
θ value	3.4976e-36 (rank : 16)	NC score	0.822834 (rank : 9)
Query Neighborhood Hits	76	Target Neighborhood Hits	125	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC3_MOUSE
θ value	3.4976e-36 (rank : 17)	NC score	0.814410 (rank : 15)
Query Neighborhood Hits	76	Target Neighborhood Hits	274	Shared Neighborhood Hits	27
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

PSD4_HUMAN
θ value	7.82807e-20 (rank : 18)	NC score	0.699196 (rank : 22)
Query Neighborhood Hits	76	Target Neighborhood Hits	178	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

FBX8_MOUSE
θ value	1.02238e-19 (rank : 19)	NC score	0.775602 (rank : 16)
Query Neighborhood Hits	76	Target Neighborhood Hits	45	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FBX8_HUMAN
θ value	1.74391e-19 (rank : 20)	NC score	0.773199 (rank : 19)
Query Neighborhood Hits	76	Target Neighborhood Hits	44	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

PSD3_HUMAN
θ value	1.74391e-19 (rank : 21)	NC score	0.738398 (rank : 20)
Query Neighborhood Hits	76	Target Neighborhood Hits	75	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_MOUSE
θ value	9.56915e-18 (rank : 22)	NC score	0.703223 (rank : 21)
Query Neighborhood Hits	76	Target Neighborhood Hits	78	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

EMSY_HUMAN
θ value	0.21417 (rank : 23)	NC score	0.040558 (rank : 62)
Query Neighborhood Hits	76	Target Neighborhood Hits	296	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

TTC28_HUMAN
θ value	0.365318 (rank : 24)	NC score	0.030145 (rank : 64)
Query Neighborhood Hits	76	Target Neighborhood Hits	271	Shared Neighborhood Hits	8
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

EMSY_MOUSE
θ value	0.47712 (rank : 25)	NC score	0.040004 (rank : 63)
Query Neighborhood Hits	76	Target Neighborhood Hits	294	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

DNJC8_MOUSE
θ value	0.813845 (rank : 26)	NC score	0.017158 (rank : 75)
Query Neighborhood Hits	76	Target Neighborhood Hits	392	Shared Neighborhood Hits	6
SwissProt Accessions	Q6NZB0, Q6PG72, Q8C2M6	Gene names	Dnajc8
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 8.

GCC2_HUMAN
θ value	0.813845 (rank : 27)	NC score	0.008091 (rank : 99)
Query Neighborhood Hits	76	Target Neighborhood Hits	1558	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

PEPL_HUMAN
θ value	0.813845 (rank : 28)	NC score	0.010629 (rank : 88)
Query Neighborhood Hits	76	Target Neighborhood Hits	1141	Shared Neighborhood Hits	17
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

RBP24_HUMAN
θ value	0.813845 (rank : 29)	NC score	0.008093 (rank : 98)
Query Neighborhood Hits	76	Target Neighborhood Hits	1559	Shared Neighborhood Hits	24
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

MAOX_HUMAN
θ value	1.06291 (rank : 30)	NC score	0.015217 (rank : 80)
Query Neighborhood Hits	76	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	P48163, Q16797, Q16855, Q53F72, Q5VWA2, Q9BWX8, Q9H1W3, Q9UIY4	Gene names	ME1
Domain Architecture
Description	NADP-dependent malic enzyme (EC 1.1.1.40) (NADP-ME) (Malic enzyme 1).

CEP63_HUMAN
θ value	1.38821 (rank : 31)	NC score	0.007844 (rank : 100)
Query Neighborhood Hits	76	Target Neighborhood Hits	1005	Shared Neighborhood Hits	13
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

ERCC3_MOUSE
θ value	1.38821 (rank : 32)	NC score	0.021835 (rank : 67)
Query Neighborhood Hits	76	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	P49135	Gene names	Ercc3, Xpb, Xpbc
Domain Architecture
Description	TFIIH basal transcription factor complex helicase XPB subunit (EC 3.6.1.-) (Basic transcription factor 2 89 kDa subunit) (BTF2-p89) (TFIIH 89 kDa subunit) (DNA-repair protein complementing XP-B cells) (Xeroderma pigmentosum group B-complementing protein) (DNA excision repair protein ERCC-3).

TTC28_MOUSE
θ value	1.38821 (rank : 33)	NC score	0.027881 (rank : 65)
Query Neighborhood Hits	76	Target Neighborhood Hits	194	Shared Neighborhood Hits	7
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

ZBT24_HUMAN
θ value	1.38821 (rank : 34)	NC score	-0.002085 (rank : 114)
Query Neighborhood Hits	76	Target Neighborhood Hits	870	Shared Neighborhood Hits	2
SwissProt Accessions	O43167, Q5TED5, Q8N455	Gene names	ZBTB24, KIAA0441, ZNF450
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450).

RENT1_HUMAN
θ value	1.81305 (rank : 35)	NC score	0.019741 (rank : 70)
Query Neighborhood Hits	76	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q92900, O00239, O43343, Q86Z25, Q92842	Gene names	UPF1, KIAA0221, RENT1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (hUpf1).

RENT1_MOUSE
θ value	1.81305 (rank : 36)	NC score	0.019714 (rank : 71)
Query Neighborhood Hits	76	Target Neighborhood Hits	54	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPU0, Q99PR4	Gene names	Upf1, Rent1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (mUpf1).

K1045_HUMAN
θ value	2.36792 (rank : 37)	NC score	0.020696 (rank : 69)
Query Neighborhood Hits	76	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UPV7, Q58FE9, Q5T662	Gene names	KIAA1045
Domain Architecture	No domain graphic available
Description	Protein KIAA1045.

S45A3_MOUSE
θ value	2.36792 (rank : 38)	NC score	0.016930 (rank : 76)
Query Neighborhood Hits	76	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K0H7, Q8K252, Q8R1I0	Gene names	Slc45a3, Pcanap6, Prst
Domain Architecture	No domain graphic available
Description	Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein).

STX7_MOUSE
θ value	2.36792 (rank : 39)	NC score	0.015628 (rank : 77)
Query Neighborhood Hits	76	Target Neighborhood Hits	131	Shared Neighborhood Hits	6
SwissProt Accessions	O70439	Gene names	Stx7, Syn7
Domain Architecture
Description	Syntaxin-7.

MAGH1_MOUSE
θ value	3.0926 (rank : 40)	NC score	0.008105 (rank : 97)
Query Neighborhood Hits	76	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NWG9, Q99PB0	Gene names	Mageh1
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen H1 (MAGE-H1 antigen).

BMP2K_HUMAN
θ value	4.03905 (rank : 41)	NC score	0.000164 (rank : 111)
Query Neighborhood Hits	76	Target Neighborhood Hits	867	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BSN_HUMAN
θ value	4.03905 (rank : 42)	NC score	0.017249 (rank : 74)
Query Neighborhood Hits	76	Target Neighborhood Hits	1537	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

BSN_MOUSE
θ value	4.03905 (rank : 43)	NC score	0.021193 (rank : 68)
Query Neighborhood Hits	76	Target Neighborhood Hits	2057	Shared Neighborhood Hits	25
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

LAMA5_MOUSE
θ value	4.03905 (rank : 44)	NC score	0.002649 (rank : 110)
Query Neighborhood Hits	76	Target Neighborhood Hits	828	Shared Neighborhood Hits	9
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

NADAP_HUMAN
θ value	4.03905 (rank : 45)	NC score	0.017963 (rank : 73)
Query Neighborhood Hits	76	Target Neighborhood Hits	208	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BWU0, Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2	Gene names	SLC4A1AP, HLC3
Domain Architecture	No domain graphic available
Description	Kanadaptin (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) (Lung cancer oncogene 3 protein).

OTOF_MOUSE
θ value	4.03905 (rank : 46)	NC score	0.008508 (rank : 96)
Query Neighborhood Hits	76	Target Neighborhood Hits	196	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

RNF17_MOUSE
θ value	4.03905 (rank : 47)	NC score	0.018023 (rank : 72)
Query Neighborhood Hits	76	Target Neighborhood Hits	147	Shared Neighborhood Hits	6
SwissProt Accessions	Q99MV7	Gene names	Rnf17
Domain Architecture
Description	RING finger protein 17.

ST5_MOUSE
θ value	4.03905 (rank : 48)	NC score	0.007286 (rank : 102)
Query Neighborhood Hits	76	Target Neighborhood Hits	126	Shared Neighborhood Hits	2
SwissProt Accessions	Q924W7, Q78H54, Q8K2P3, Q924W8	Gene names	St5, Dennd2b
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (DENN domain-containing protein 2B).

UT14B_MOUSE
θ value	4.03905 (rank : 49)	NC score	0.011052 (rank : 87)
Query Neighborhood Hits	76	Target Neighborhood Hits	226	Shared Neighborhood Hits	9
SwissProt Accessions	Q6EJB6, Q6EJB5, Q8BL60	Gene names	Utp14b, Jsd
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 14 homolog B (Juvenile spermatogonial depletion protein).

CELR2_HUMAN
θ value	5.27518 (rank : 50)	NC score	-0.000283 (rank : 112)
Query Neighborhood Hits	76	Target Neighborhood Hits	657	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HCU4, Q92566	Gene names	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).

DYHC_HUMAN
θ value	5.27518 (rank : 51)	NC score	0.009798 (rank : 90)
Query Neighborhood Hits	76	Target Neighborhood Hits	733	Shared Neighborhood Hits	9
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_MOUSE
θ value	5.27518 (rank : 52)	NC score	0.009758 (rank : 91)
Query Neighborhood Hits	76	Target Neighborhood Hits	729	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

E2F1_MOUSE
θ value	5.27518 (rank : 53)	NC score	0.015341 (rank : 78)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q61501, Q80VZ3	Gene names	E2f1
Domain Architecture
Description	Transcription factor E2F1 (E2F-1).

FA76B_MOUSE
θ value	5.27518 (rank : 54)	NC score	0.010617 (rank : 89)
Query Neighborhood Hits	76	Target Neighborhood Hits	181	Shared Neighborhood Hits	6
SwissProt Accessions	Q80XP8, Q3UMA6, Q80YR1, Q8CI69	Gene names	Fam76b
Domain Architecture	No domain graphic available
Description	Protein FAM76B.

FRM4A_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.005143 (rank : 107)
Query Neighborhood Hits	76	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

K0100_HUMAN
θ value	5.27518 (rank : 56)	NC score	0.011350 (rank : 86)
Query Neighborhood Hits	76	Target Neighborhood Hits	132	Shared Neighborhood Hits	4
SwissProt Accessions	Q14667, Q3SYN5, Q49A07, Q5H9T4, Q6WG74, Q6ZP51, Q96HH8	Gene names	KIAA0100, BCOX1
Domain Architecture	No domain graphic available
Description	UPF0378 family protein KIAA0100 precursor (Breast cancer overexpressed gene 1 protein) (Antigen MLAA-22).

KI67_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.011709 (rank : 85)
Query Neighborhood Hits	76	Target Neighborhood Hits	581	Shared Neighborhood Hits	13
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

PK3CD_MOUSE
θ value	5.27518 (rank : 58)	NC score	0.005232 (rank : 106)
Query Neighborhood Hits	76	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

AKA12_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.009036 (rank : 92)
Query Neighborhood Hits	76	Target Neighborhood Hits	825	Shared Neighborhood Hits	14
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

PRG4_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.005514 (rank : 105)
Query Neighborhood Hits	76	Target Neighborhood Hits	764	Shared Neighborhood Hits	11
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

STX7_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.012580 (rank : 84)
Query Neighborhood Hits	76	Target Neighborhood Hits	111	Shared Neighborhood Hits	6
SwissProt Accessions	O15400, Q5SZW2, Q96ES9	Gene names	STX7
Domain Architecture
Description	Syntaxin-7.

UBP2L_MOUSE
θ value	6.88961 (rank : 62)	NC score	0.013681 (rank : 82)
Query Neighborhood Hits	76	Target Neighborhood Hits	173	Shared Neighborhood Hits	8
SwissProt Accessions	Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6	Gene names	Ubap2l
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 2-like.

ABTAP_HUMAN
θ value	8.99809 (rank : 63)	NC score	0.007541 (rank : 101)
Query Neighborhood Hits	76	Target Neighborhood Hits	290	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H501, Q86X92, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6	Gene names	ABTAP, C20orf6
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

AKAP9_HUMAN
θ value	8.99809 (rank : 64)	NC score	0.003823 (rank : 109)
Query Neighborhood Hits	76	Target Neighborhood Hits	1710	Shared Neighborhood Hits	22
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

DSPP_MOUSE
θ value	8.99809 (rank : 65)	NC score	0.005532 (rank : 104)
Query Neighborhood Hits	76	Target Neighborhood Hits	491	Shared Neighborhood Hits	6
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

E2F1_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.008896 (rank : 94)
Query Neighborhood Hits	76	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q01094, Q13143, Q92768	Gene names	E2F1, RBBP3
Domain Architecture
Description	Transcription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3) (RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1).

GATA2_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.004731 (rank : 108)
Query Neighborhood Hits	76	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	P23769, Q9BUJ6	Gene names	GATA2
Domain Architecture
Description	Endothelial transcription factor GATA-2 (GATA-binding protein 2).

MK13_MOUSE
θ value	8.99809 (rank : 68)	NC score	-0.003099 (rank : 115)
Query Neighborhood Hits	76	Target Neighborhood Hits	832	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MUC7_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.006303 (rank : 103)
Query Neighborhood Hits	76	Target Neighborhood Hits	538	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

NCOA6_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.023020 (rank : 66)
Query Neighborhood Hits	76	Target Neighborhood Hits	1202	Shared Neighborhood Hits	21
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NCOA6_MOUSE
θ value	8.99809 (rank : 71)	NC score	0.014043 (rank : 81)
Query Neighborhood Hits	76	Target Neighborhood Hits	1076	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

PCLO_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.008724 (rank : 95)
Query Neighborhood Hits	76	Target Neighborhood Hits	2046	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PDXL2_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.009023 (rank : 93)
Query Neighborhood Hits	76	Target Neighborhood Hits	75	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZ53, Q6UVY4, Q8WUV6	Gene names	PODXL2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

RNF17_HUMAN
θ value	8.99809 (rank : 74)	NC score	0.015245 (rank : 79)
Query Neighborhood Hits	76	Target Neighborhood Hits	71	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BXT8, Q9BXT7	Gene names	RNF17
Domain Architecture
Description	RING finger protein 17.

TITIN_HUMAN
θ value	8.99809 (rank : 75)	NC score	-0.001578 (rank : 113)
Query Neighborhood Hits	76	Target Neighborhood Hits	2923	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

UBP2L_HUMAN
θ value	8.99809 (rank : 76)	NC score	0.012612 (rank : 83)
Query Neighborhood Hits	76	Target Neighborhood Hits	170	Shared Neighborhood Hits	7
SwissProt Accessions	Q14157, Q5VU75, Q5VU76, Q9BTU3, Q9UGL5	Gene names	UBAP2L, KIAA0144, NICE4
Domain Architecture
Description	Ubiquitin-associated protein 2-like (Protein NICE-4).

3BP2_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.107241 (rank : 37)
Query Neighborhood Hits	76	Target Neighborhood Hits	296	Shared Neighborhood Hits	14
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.110450 (rank : 34)
Query Neighborhood Hits	76	Target Neighborhood Hits	142	Shared Neighborhood Hits	9
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ANLN_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.113024 (rank : 33)
Query Neighborhood Hits	76	Target Neighborhood Hits	222	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

ANLN_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.094252 (rank : 43)
Query Neighborhood Hits	76	Target Neighborhood Hits	297	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

CENB2_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.064986 (rank : 49)
Query Neighborhood Hits	76	Target Neighborhood Hits	425	Shared Neighborhood Hits	13
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.059469 (rank : 51)
Query Neighborhood Hits	76	Target Neighborhood Hits	395	Shared Neighborhood Hits	12
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CNKR1_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.184382 (rank : 23)
Query Neighborhood Hits	76	Target Neighborhood Hits	154	Shared Neighborhood Hits	14
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.096162 (rank : 42)
Query Neighborhood Hits	76	Target Neighborhood Hits	197	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.096247 (rank : 41)
Query Neighborhood Hits	76	Target Neighborhood Hits	197	Shared Neighborhood Hits	10
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

DAPP1_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.108376 (rank : 36)
Query Neighborhood Hits	76	Target Neighborhood Hits	227	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.114022 (rank : 32)
Query Neighborhood Hits	76	Target Neighborhood Hits	225	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DYN2_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.052141 (rank : 59)
Query Neighborhood Hits	76	Target Neighborhood Hits	112	Shared Neighborhood Hits	11
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.052089 (rank : 60)
Query Neighborhood Hits	76	Target Neighborhood Hits	104	Shared Neighborhood Hits	10
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

DYN3_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.052616 (rank : 56)
Query Neighborhood Hits	76	Target Neighborhood Hits	158	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

GNRP_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.054737 (rank : 53)
Query Neighborhood Hits	76	Target Neighborhood Hits	239	Shared Neighborhood Hits	9
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.052305 (rank : 57)
Query Neighborhood Hits	76	Target Neighborhood Hits	191	Shared Neighborhood Hits	9
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

MTMR5_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.053724 (rank : 55)
Query Neighborhood Hits	76	Target Neighborhood Hits	141	Shared Neighborhood Hits	9
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

PKHA1_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.131357 (rank : 25)
Query Neighborhood Hits	76	Target Neighborhood Hits	127	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.130898 (rank : 27)
Query Neighborhood Hits	76	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.102133 (rank : 38)
Query Neighborhood Hits	76	Target Neighborhood Hits	119	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.115720 (rank : 31)
Query Neighborhood Hits	76	Target Neighborhood Hits	116	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA4_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.109589 (rank : 35)
Query Neighborhood Hits	76	Target Neighborhood Hits	283	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.119241 (rank : 30)
Query Neighborhood Hits	76	Target Neighborhood Hits	202	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.093555 (rank : 44)
Query Neighborhood Hits	76	Target Neighborhood Hits	455	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.131527 (rank : 24)
Query Neighborhood Hits	76	Target Neighborhood Hits	556	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.126493 (rank : 29)
Query Neighborhood Hits	76	Target Neighborhood Hits	591	Shared Neighborhood Hits	22
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHB1_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.050762 (rank : 61)
Query Neighborhood Hits	76	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB2_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.055842 (rank : 52)
Query Neighborhood Hits	76	Target Neighborhood Hits	54	Shared Neighborhood Hits	9
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHB2_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.054290 (rank : 54)
Query Neighborhood Hits	76	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PLEK2_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.098093 (rank : 40)
Query Neighborhood Hits	76	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.099819 (rank : 39)
Query Neighborhood Hits	76	Target Neighborhood Hits	96	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.128207 (rank : 28)
Query Neighborhood Hits	76	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.131293 (rank : 26)
Query Neighborhood Hits	76	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

RASA1_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.077674 (rank : 45)
Query Neighborhood Hits	76	Target Neighborhood Hits	258	Shared Neighborhood Hits	9
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RHG25_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.072243 (rank : 47)
Query Neighborhood Hits	76	Target Neighborhood Hits	550	Shared Neighborhood Hits	13
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.075833 (rank : 46)
Query Neighborhood Hits	76	Target Neighborhood Hits	492	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SWP70_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.068799 (rank : 48)
Query Neighborhood Hits	76	Target Neighborhood Hits	973	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.060020 (rank : 50)
Query Neighborhood Hits	76	Target Neighborhood Hits	1097	Shared Neighborhood Hits	21
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TBCD2_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.052277 (rank : 58)
Query Neighborhood Hits	76	Target Neighborhood Hits	419	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

Hits sorted by NC score

BIG1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BIG2_HUMAN
NC score	0.992959 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	76	Target Neighborhood Hits	66	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

GBF1_HUMAN
NC score	0.869742 (rank : 3)	θ value	3.59435e-57 (rank : 3)
Query Neighborhood Hits	76	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

CYH2_MOUSE
NC score	0.824918 (rank : 4)	θ value	4.40402e-47 (rank : 9)
Query Neighborhood Hits	76	Target Neighborhood Hits	171	Shared Neighborhood Hits	24
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.824890 (rank : 5)	θ value	2.58187e-47 (rank : 8)
Query Neighborhood Hits	76	Target Neighborhood Hits	175	Shared Neighborhood Hits	24
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH3_HUMAN
NC score	0.824502 (rank : 6)	θ value	4.70527e-49 (rank : 6)
Query Neighborhood Hits	76	Target Neighborhood Hits	137	Shared Neighborhood Hits	23
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH4_MOUSE
NC score	0.823648 (rank : 7)	θ value	1.28137e-46 (rank : 10)
Query Neighborhood Hits	76	Target Neighborhood Hits	134	Shared Neighborhood Hits	22
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH1_MOUSE
NC score	0.823544 (rank : 8)	θ value	8.57503e-51 (rank : 4)
Query Neighborhood Hits	76	Target Neighborhood Hits	176	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

IQEC3_HUMAN
NC score	0.822834 (rank : 9)	θ value	3.4976e-36 (rank : 16)
Query Neighborhood Hits	76	Target Neighborhood Hits	125	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

CYH4_HUMAN
NC score	0.822585 (rank : 10)	θ value	4.122e-45 (rank : 11)
Query Neighborhood Hits	76	Target Neighborhood Hits	135	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH1_HUMAN
NC score	0.821107 (rank : 11)	θ value	1.11993e-50 (rank : 5)
Query Neighborhood Hits	76	Target Neighborhood Hits	184	Shared Neighborhood Hits	22
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

IQEC1_MOUSE
NC score	0.820386 (rank : 12)	θ value	4.41421e-39 (rank : 12)
Query Neighborhood Hits	76	Target Neighborhood Hits	54	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

CYH3_MOUSE
NC score	0.818605 (rank : 13)	θ value	8.02596e-49 (rank : 7)
Query Neighborhood Hits	76	Target Neighborhood Hits	148	Shared Neighborhood Hits	23
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

IQEC1_HUMAN
NC score	0.817990 (rank : 14)	θ value	5.76516e-39 (rank : 13)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	25
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC3_MOUSE
NC score	0.814410 (rank : 15)	θ value	3.4976e-36 (rank : 17)
Query Neighborhood Hits	76	Target Neighborhood Hits	274	Shared Neighborhood Hits	27
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

FBX8_MOUSE
NC score	0.775602 (rank : 16)	θ value	1.02238e-19 (rank : 19)
Query Neighborhood Hits	76	Target Neighborhood Hits	45	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

IQEC2_HUMAN
NC score	0.775007 (rank : 17)	θ value	2.19075e-38 (rank : 15)
Query Neighborhood Hits	76	Target Neighborhood Hits	403	Shared Neighborhood Hits	26
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_MOUSE
NC score	0.774822 (rank : 18)	θ value	1.6774e-38 (rank : 14)
Query Neighborhood Hits	76	Target Neighborhood Hits	417	Shared Neighborhood Hits	26
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

FBX8_HUMAN
NC score	0.773199 (rank : 19)	θ value	1.74391e-19 (rank : 20)
Query Neighborhood Hits	76	Target Neighborhood Hits	44	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

PSD3_HUMAN
NC score	0.738398 (rank : 20)	θ value	1.74391e-19 (rank : 21)
Query Neighborhood Hits	76	Target Neighborhood Hits	75	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_MOUSE
NC score	0.703223 (rank : 21)	θ value	9.56915e-18 (rank : 22)
Query Neighborhood Hits	76	Target Neighborhood Hits	78	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

PSD4_HUMAN
NC score	0.699196 (rank : 22)	θ value	7.82807e-20 (rank : 18)
Query Neighborhood Hits	76	Target Neighborhood Hits	178	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

CNKR1_HUMAN
NC score	0.184382 (rank : 23)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	76	Target Neighborhood Hits	154	Shared Neighborhood Hits	14
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

PKHA6_HUMAN
NC score	0.131527 (rank : 24)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	76	Target Neighborhood Hits	556	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA1_HUMAN
NC score	0.131357 (rank : 25)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	76	Target Neighborhood Hits	127	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PLEK_MOUSE
NC score	0.131293 (rank : 26)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	76	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PKHA1_MOUSE
NC score	0.130898 (rank : 27)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	76	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PLEK_HUMAN
NC score	0.128207 (rank : 28)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	76	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PKHA6_MOUSE
NC score	0.126493 (rank : 29)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	76	Target Neighborhood Hits	591	Shared Neighborhood Hits	22
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA4_MOUSE
NC score	0.119241 (rank : 30)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	76	Target Neighborhood Hits	202	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA2_MOUSE
NC score	0.115720 (rank : 31)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	76	Target Neighborhood Hits	116	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

DAPP1_MOUSE
NC score	0.114022 (rank : 32)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	76	Target Neighborhood Hits	225	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ANLN_HUMAN
NC score	0.113024 (rank : 33)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	76	Target Neighborhood Hits	222	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

3BP2_MOUSE
NC score	0.110450 (rank : 34)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	76	Target Neighborhood Hits	142	Shared Neighborhood Hits	9
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PKHA4_HUMAN
NC score	0.109589 (rank : 35)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	76	Target Neighborhood Hits	283	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

DAPP1_HUMAN
NC score	0.108376 (rank : 36)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	76	Target Neighborhood Hits	227	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

3BP2_HUMAN
NC score	0.107241 (rank : 37)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	76	Target Neighborhood Hits	296	Shared Neighborhood Hits	14
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PKHA2_HUMAN
NC score	0.102133 (rank : 38)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	76	Target Neighborhood Hits	119	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PLEK2_MOUSE
NC score	0.099819 (rank : 39)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	76	Target Neighborhood Hits	96	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_HUMAN
NC score	0.098093 (rank : 40)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	76	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

CNKR2_MOUSE
NC score	0.096247 (rank : 41)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	76	Target Neighborhood Hits	197	Shared Neighborhood Hits	10
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.096162 (rank : 42)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	76	Target Neighborhood Hits	197	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ANLN_MOUSE
NC score	0.094252 (rank : 43)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	76	Target Neighborhood Hits	297	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

PKHA5_HUMAN
NC score	0.093555 (rank : 44)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	76	Target Neighborhood Hits	455	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RASA1_HUMAN
NC score	0.077674 (rank : 45)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	76	Target Neighborhood Hits	258	Shared Neighborhood Hits	9
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RHG25_MOUSE
NC score	0.075833 (rank : 46)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	76	Target Neighborhood Hits	492	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_HUMAN
NC score	0.072243 (rank : 47)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	76	Target Neighborhood Hits	550	Shared Neighborhood Hits	13
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SWP70_HUMAN
NC score	0.068799 (rank : 48)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	76	Target Neighborhood Hits	973	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CENB2_HUMAN
NC score	0.064986 (rank : 49)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	76	Target Neighborhood Hits	425	Shared Neighborhood Hits	13
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

SWP70_MOUSE
NC score	0.060020 (rank : 50)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	76	Target Neighborhood Hits	1097	Shared Neighborhood Hits	21
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CENB5_HUMAN
NC score	0.059469 (rank : 51)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	76	Target Neighborhood Hits	395	Shared Neighborhood Hits	12
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

PKHB2_HUMAN
NC score	0.055842 (rank : 52)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	76	Target Neighborhood Hits	54	Shared Neighborhood Hits	9
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

GNRP_HUMAN
NC score	0.054737 (rank : 53)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	76	Target Neighborhood Hits	239	Shared Neighborhood Hits	9
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

PKHB2_MOUSE
NC score	0.054290 (rank : 54)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	76	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

MTMR5_HUMAN
NC score	0.053724 (rank : 55)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	76	Target Neighborhood Hits	141	Shared Neighborhood Hits	9
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

DYN3_HUMAN
NC score	0.052616 (rank : 56)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	76	Target Neighborhood Hits	158	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

GNRP_MOUSE
NC score	0.052305 (rank : 57)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	76	Target Neighborhood Hits	191	Shared Neighborhood Hits	9
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

TBCD2_HUMAN
NC score	0.052277 (rank : 58)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	76	Target Neighborhood Hits	419	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

DYN2_HUMAN
NC score	0.052141 (rank : 59)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	76	Target Neighborhood Hits	112	Shared Neighborhood Hits	11
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
NC score	0.052089 (rank : 60)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	76	Target Neighborhood Hits	104	Shared Neighborhood Hits	10
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

PKHB1_HUMAN
NC score	0.050762 (rank : 61)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	76	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

EMSY_HUMAN
NC score	0.040558 (rank : 62)	θ value	0.21417 (rank : 23)
Query Neighborhood Hits	76	Target Neighborhood Hits	296	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

EMSY_MOUSE
NC score	0.040004 (rank : 63)	θ value	0.47712 (rank : 25)
Query Neighborhood Hits	76	Target Neighborhood Hits	294	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

TTC28_HUMAN
NC score	0.030145 (rank : 64)	θ value	0.365318 (rank : 24)
Query Neighborhood Hits	76	Target Neighborhood Hits	271	Shared Neighborhood Hits	8
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

TTC28_MOUSE
NC score	0.027881 (rank : 65)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	76	Target Neighborhood Hits	194	Shared Neighborhood Hits	7
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

NCOA6_HUMAN
NC score	0.023020 (rank : 66)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	76	Target Neighborhood Hits	1202	Shared Neighborhood Hits	21
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

ERCC3_MOUSE
NC score	0.021835 (rank : 67)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	76	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	P49135	Gene names	Ercc3, Xpb, Xpbc
Domain Architecture
Description	TFIIH basal transcription factor complex helicase XPB subunit (EC 3.6.1.-) (Basic transcription factor 2 89 kDa subunit) (BTF2-p89) (TFIIH 89 kDa subunit) (DNA-repair protein complementing XP-B cells) (Xeroderma pigmentosum group B-complementing protein) (DNA excision repair protein ERCC-3).

BSN_MOUSE
NC score	0.021193 (rank : 68)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	76	Target Neighborhood Hits	2057	Shared Neighborhood Hits	25
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

K1045_HUMAN
NC score	0.020696 (rank : 69)	θ value	2.36792 (rank : 37)
Query Neighborhood Hits	76	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UPV7, Q58FE9, Q5T662	Gene names	KIAA1045
Domain Architecture	No domain graphic available
Description	Protein KIAA1045.

RENT1_HUMAN
NC score	0.019741 (rank : 70)	θ value	1.81305 (rank : 35)
Query Neighborhood Hits	76	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q92900, O00239, O43343, Q86Z25, Q92842	Gene names	UPF1, KIAA0221, RENT1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (hUpf1).

RENT1_MOUSE
NC score	0.019714 (rank : 71)	θ value	1.81305 (rank : 36)
Query Neighborhood Hits	76	Target Neighborhood Hits	54	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPU0, Q99PR4	Gene names	Upf1, Rent1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (mUpf1).

RNF17_MOUSE
NC score	0.018023 (rank : 72)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	76	Target Neighborhood Hits	147	Shared Neighborhood Hits	6
SwissProt Accessions	Q99MV7	Gene names	Rnf17
Domain Architecture
Description	RING finger protein 17.

NADAP_HUMAN
NC score	0.017963 (rank : 73)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	76	Target Neighborhood Hits	208	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BWU0, Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2	Gene names	SLC4A1AP, HLC3
Domain Architecture	No domain graphic available
Description	Kanadaptin (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) (Lung cancer oncogene 3 protein).

BSN_HUMAN
NC score	0.017249 (rank : 74)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	76	Target Neighborhood Hits	1537	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

DNJC8_MOUSE
NC score	0.017158 (rank : 75)	θ value	0.813845 (rank : 26)
Query Neighborhood Hits	76	Target Neighborhood Hits	392	Shared Neighborhood Hits	6
SwissProt Accessions	Q6NZB0, Q6PG72, Q8C2M6	Gene names	Dnajc8
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 8.

S45A3_MOUSE
NC score	0.016930 (rank : 76)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	76	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K0H7, Q8K252, Q8R1I0	Gene names	Slc45a3, Pcanap6, Prst
Domain Architecture	No domain graphic available
Description	Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein).

STX7_MOUSE
NC score	0.015628 (rank : 77)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	76	Target Neighborhood Hits	131	Shared Neighborhood Hits	6
SwissProt Accessions	O70439	Gene names	Stx7, Syn7
Domain Architecture
Description	Syntaxin-7.

E2F1_MOUSE
NC score	0.015341 (rank : 78)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q61501, Q80VZ3	Gene names	E2f1
Domain Architecture
Description	Transcription factor E2F1 (E2F-1).

RNF17_HUMAN
NC score	0.015245 (rank : 79)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	76	Target Neighborhood Hits	71	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BXT8, Q9BXT7	Gene names	RNF17
Domain Architecture
Description	RING finger protein 17.

MAOX_HUMAN
NC score	0.015217 (rank : 80)	θ value	1.06291 (rank : 30)
Query Neighborhood Hits	76	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	P48163, Q16797, Q16855, Q53F72, Q5VWA2, Q9BWX8, Q9H1W3, Q9UIY4	Gene names	ME1
Domain Architecture
Description	NADP-dependent malic enzyme (EC 1.1.1.40) (NADP-ME) (Malic enzyme 1).

NCOA6_MOUSE
NC score	0.014043 (rank : 81)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	76	Target Neighborhood Hits	1076	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

UBP2L_MOUSE
NC score	0.013681 (rank : 82)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	76	Target Neighborhood Hits	173	Shared Neighborhood Hits	8
SwissProt Accessions	Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6	Gene names	Ubap2l
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 2-like.

UBP2L_HUMAN
NC score	0.012612 (rank : 83)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	76	Target Neighborhood Hits	170	Shared Neighborhood Hits	7
SwissProt Accessions	Q14157, Q5VU75, Q5VU76, Q9BTU3, Q9UGL5	Gene names	UBAP2L, KIAA0144, NICE4
Domain Architecture
Description	Ubiquitin-associated protein 2-like (Protein NICE-4).

STX7_HUMAN
NC score	0.012580 (rank : 84)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	76	Target Neighborhood Hits	111	Shared Neighborhood Hits	6
SwissProt Accessions	O15400, Q5SZW2, Q96ES9	Gene names	STX7
Domain Architecture
Description	Syntaxin-7.

KI67_HUMAN
NC score	0.011709 (rank : 85)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	76	Target Neighborhood Hits	581	Shared Neighborhood Hits	13
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

K0100_HUMAN
NC score	0.011350 (rank : 86)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	76	Target Neighborhood Hits	132	Shared Neighborhood Hits	4
SwissProt Accessions	Q14667, Q3SYN5, Q49A07, Q5H9T4, Q6WG74, Q6ZP51, Q96HH8	Gene names	KIAA0100, BCOX1
Domain Architecture	No domain graphic available
Description	UPF0378 family protein KIAA0100 precursor (Breast cancer overexpressed gene 1 protein) (Antigen MLAA-22).

UT14B_MOUSE
NC score	0.011052 (rank : 87)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	76	Target Neighborhood Hits	226	Shared Neighborhood Hits	9
SwissProt Accessions	Q6EJB6, Q6EJB5, Q8BL60	Gene names	Utp14b, Jsd
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 14 homolog B (Juvenile spermatogonial depletion protein).

PEPL_HUMAN
NC score	0.010629 (rank : 88)	θ value	0.813845 (rank : 28)
Query Neighborhood Hits	76	Target Neighborhood Hits	1141	Shared Neighborhood Hits	17
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

FA76B_MOUSE
NC score	0.010617 (rank : 89)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	76	Target Neighborhood Hits	181	Shared Neighborhood Hits	6
SwissProt Accessions	Q80XP8, Q3UMA6, Q80YR1, Q8CI69	Gene names	Fam76b
Domain Architecture	No domain graphic available
Description	Protein FAM76B.

DYHC_HUMAN
NC score	0.009798 (rank : 90)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	76	Target Neighborhood Hits	733	Shared Neighborhood Hits	9
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_MOUSE
NC score	0.009758 (rank : 91)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	76	Target Neighborhood Hits	729	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

AKA12_HUMAN
NC score	0.009036 (rank : 92)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	76	Target Neighborhood Hits	825	Shared Neighborhood Hits	14
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

PDXL2_HUMAN
NC score	0.009023 (rank : 93)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	76	Target Neighborhood Hits	75	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZ53, Q6UVY4, Q8WUV6	Gene names	PODXL2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

E2F1_HUMAN
NC score	0.008896 (rank : 94)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	76	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q01094, Q13143, Q92768	Gene names	E2F1, RBBP3
Domain Architecture
Description	Transcription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3) (RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1).

PCLO_HUMAN
NC score	0.008724 (rank : 95)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	76	Target Neighborhood Hits	2046	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

OTOF_MOUSE
NC score	0.008508 (rank : 96)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	76	Target Neighborhood Hits	196	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

MAGH1_MOUSE
NC score	0.008105 (rank : 97)	θ value	3.0926 (rank : 40)
Query Neighborhood Hits	76	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NWG9, Q99PB0	Gene names	Mageh1
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen H1 (MAGE-H1 antigen).

RBP24_HUMAN
NC score	0.008093 (rank : 98)	θ value	0.813845 (rank : 29)
Query Neighborhood Hits	76	Target Neighborhood Hits	1559	Shared Neighborhood Hits	24
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

GCC2_HUMAN
NC score	0.008091 (rank : 99)	θ value	0.813845 (rank : 27)
Query Neighborhood Hits	76	Target Neighborhood Hits	1558	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

CEP63_HUMAN
NC score	0.007844 (rank : 100)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	76	Target Neighborhood Hits	1005	Shared Neighborhood Hits	13
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

ABTAP_HUMAN
NC score	0.007541 (rank : 101)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	76	Target Neighborhood Hits	290	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H501, Q86X92, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6	Gene names	ABTAP, C20orf6
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

ST5_MOUSE
NC score	0.007286 (rank : 102)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	76	Target Neighborhood Hits	126	Shared Neighborhood Hits	2
SwissProt Accessions	Q924W7, Q78H54, Q8K2P3, Q924W8	Gene names	St5, Dennd2b
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (DENN domain-containing protein 2B).

MUC7_HUMAN
NC score	0.006303 (rank : 103)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	76	Target Neighborhood Hits	538	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

DSPP_MOUSE
NC score	0.005532 (rank : 104)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	76	Target Neighborhood Hits	491	Shared Neighborhood Hits	6
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

PRG4_HUMAN
NC score	0.005514 (rank : 105)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	76	Target Neighborhood Hits	764	Shared Neighborhood Hits	11
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PK3CD_MOUSE
NC score	0.005232 (rank : 106)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	76	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

FRM4A_HUMAN
NC score	0.005143 (rank : 107)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	76	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

GATA2_HUMAN
NC score	0.004731 (rank : 108)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	76	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	P23769, Q9BUJ6	Gene names	GATA2
Domain Architecture
Description	Endothelial transcription factor GATA-2 (GATA-binding protein 2).

AKAP9_HUMAN
NC score	0.003823 (rank : 109)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	76	Target Neighborhood Hits	1710	Shared Neighborhood Hits	22
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

LAMA5_MOUSE
NC score	0.002649 (rank : 110)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	76	Target Neighborhood Hits	828	Shared Neighborhood Hits	9
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

BMP2K_HUMAN
NC score	0.000164 (rank : 111)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	76	Target Neighborhood Hits	867	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

CELR2_HUMAN
NC score	-0.000283 (rank : 112)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	76	Target Neighborhood Hits	657	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HCU4, Q92566	Gene names	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).

TITIN_HUMAN
NC score	-0.001578 (rank : 113)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	76	Target Neighborhood Hits	2923	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ZBT24_HUMAN
NC score	-0.002085 (rank : 114)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	76	Target Neighborhood Hits	870	Shared Neighborhood Hits	2
SwissProt Accessions	O43167, Q5TED5, Q8N455	Gene names	ZBTB24, KIAA0441, ZNF450
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450).

MK13_MOUSE
NC score	-0.003099 (rank : 115)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	76	Target Neighborhood Hits	832	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).