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Network neighborhood for query Sequence : CYH4_HUMAN

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CYH4_HUMAN
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CYH4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	135	Target Neighborhood Hits	135	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
θ value	0 (rank : 2)	NC score	0.998812 (rank : 2)
Query Neighborhood Hits	135	Target Neighborhood Hits	134	Shared Neighborhood Hits	125
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH3_MOUSE
θ value	3.36238e-172 (rank : 3)	NC score	0.991275 (rank : 3)
Query Neighborhood Hits	135	Target Neighborhood Hits	148	Shared Neighborhood Hits	120
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH3_HUMAN
θ value	8.28183e-171 (rank : 4)	NC score	0.988996 (rank : 4)
Query Neighborhood Hits	135	Target Neighborhood Hits	137	Shared Neighborhood Hits	113
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH2_MOUSE
θ value	2.11095e-166 (rank : 5)	NC score	0.988853 (rank : 5)
Query Neighborhood Hits	135	Target Neighborhood Hits	171	Shared Neighborhood Hits	117
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
θ value	5.19945e-165 (rank : 6)	NC score	0.988751 (rank : 6)
Query Neighborhood Hits	135	Target Neighborhood Hits	175	Shared Neighborhood Hits	117
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH1_HUMAN
θ value	3.37019e-164 (rank : 7)	NC score	0.985918 (rank : 8)
Query Neighborhood Hits	135	Target Neighborhood Hits	184	Shared Neighborhood Hits	116
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	3.72618e-163 (rank : 8)	NC score	0.986157 (rank : 7)
Query Neighborhood Hits	135	Target Neighborhood Hits	176	Shared Neighborhood Hits	116
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

BIG1_HUMAN
θ value	4.122e-45 (rank : 9)	NC score	0.822585 (rank : 9)
Query Neighborhood Hits	135	Target Neighborhood Hits	76	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BIG2_HUMAN
θ value	6.58091e-43 (rank : 10)	NC score	0.818462 (rank : 10)
Query Neighborhood Hits	135	Target Neighborhood Hits	66	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

IQEC1_HUMAN
θ value	5.0505e-35 (rank : 11)	NC score	0.790403 (rank : 14)
Query Neighborhood Hits	135	Target Neighborhood Hits	76	Shared Neighborhood Hits	25
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC1_MOUSE
θ value	1.46948e-34 (rank : 12)	NC score	0.791305 (rank : 13)
Query Neighborhood Hits	135	Target Neighborhood Hits	54	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

IQEC2_MOUSE
θ value	3.61944e-33 (rank : 13)	NC score	0.742977 (rank : 19)
Query Neighborhood Hits	135	Target Neighborhood Hits	417	Shared Neighborhood Hits	25
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

GBF1_HUMAN
θ value	4.72714e-33 (rank : 14)	NC score	0.810015 (rank : 11)
Query Neighborhood Hits	135	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

IQEC2_HUMAN
θ value	6.17384e-33 (rank : 15)	NC score	0.742791 (rank : 20)
Query Neighborhood Hits	135	Target Neighborhood Hits	403	Shared Neighborhood Hits	25
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC3_MOUSE
θ value	2.34606e-32 (rank : 16)	NC score	0.790345 (rank : 15)
Query Neighborhood Hits	135	Target Neighborhood Hits	274	Shared Neighborhood Hits	28
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC3_HUMAN
θ value	8.91499e-32 (rank : 17)	NC score	0.798601 (rank : 12)
Query Neighborhood Hits	135	Target Neighborhood Hits	125	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

PSD4_MOUSE
θ value	1.42661e-21 (rank : 18)	NC score	0.719851 (rank : 21)
Query Neighborhood Hits	135	Target Neighborhood Hits	78	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

PSD4_HUMAN
θ value	4.15078e-21 (rank : 19)	NC score	0.713559 (rank : 22)
Query Neighborhood Hits	135	Target Neighborhood Hits	178	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

PSD3_HUMAN
θ value	8.65492e-19 (rank : 20)	NC score	0.763484 (rank : 16)
Query Neighborhood Hits	135	Target Neighborhood Hits	75	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

FBX8_MOUSE
θ value	2.13179e-17 (rank : 21)	NC score	0.756327 (rank : 17)
Query Neighborhood Hits	135	Target Neighborhood Hits	45	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FBX8_HUMAN
θ value	2.7842e-17 (rank : 22)	NC score	0.754188 (rank : 18)
Query Neighborhood Hits	135	Target Neighborhood Hits	44	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

PLEK_MOUSE
θ value	1.29631e-06 (rank : 23)	NC score	0.377499 (rank : 27)
Query Neighborhood Hits	135	Target Neighborhood Hits	109	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

SWP70_HUMAN
θ value	1.29631e-06 (rank : 24)	NC score	0.194178 (rank : 47)
Query Neighborhood Hits	135	Target Neighborhood Hits	973	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PKHA6_HUMAN
θ value	1.69304e-06 (rank : 25)	NC score	0.370771 (rank : 28)
Query Neighborhood Hits	135	Target Neighborhood Hits	556	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

DAPP1_MOUSE
θ value	2.21117e-06 (rank : 26)	NC score	0.307421 (rank : 36)
Query Neighborhood Hits	135	Target Neighborhood Hits	225	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PLEK_HUMAN
θ value	2.21117e-06 (rank : 27)	NC score	0.378838 (rank : 26)
Query Neighborhood Hits	135	Target Neighborhood Hits	110	Shared Neighborhood Hits	75
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

DAPP1_HUMAN
θ value	3.77169e-06 (rank : 28)	NC score	0.296680 (rank : 37)
Query Neighborhood Hits	135	Target Neighborhood Hits	227	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA6_MOUSE
θ value	3.77169e-06 (rank : 29)	NC score	0.359133 (rank : 29)
Query Neighborhood Hits	135	Target Neighborhood Hits	591	Shared Neighborhood Hits	97
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CNKR1_HUMAN
θ value	4.92598e-06 (rank : 30)	NC score	0.401760 (rank : 23)
Query Neighborhood Hits	135	Target Neighborhood Hits	154	Shared Neighborhood Hits	60
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

PKHA1_HUMAN
θ value	1.09739e-05 (rank : 31)	NC score	0.380469 (rank : 24)
Query Neighborhood Hits	135	Target Neighborhood Hits	127	Shared Neighborhood Hits	74
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	1.09739e-05 (rank : 32)	NC score	0.379222 (rank : 25)
Query Neighborhood Hits	135	Target Neighborhood Hits	120	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

RHG25_MOUSE
θ value	1.09739e-05 (rank : 33)	NC score	0.224886 (rank : 44)
Query Neighborhood Hits	135	Target Neighborhood Hits	492	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SWP70_MOUSE
θ value	1.87187e-05 (rank : 34)	NC score	0.179463 (rank : 48)
Query Neighborhood Hits	135	Target Neighborhood Hits	1097	Shared Neighborhood Hits	85
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

RHG25_HUMAN
θ value	2.44474e-05 (rank : 35)	NC score	0.221948 (rank : 45)
Query Neighborhood Hits	135	Target Neighborhood Hits	550	Shared Neighborhood Hits	94
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

GNRP_HUMAN
θ value	4.1701e-05 (rank : 36)	NC score	0.163528 (rank : 53)
Query Neighborhood Hits	135	Target Neighborhood Hits	239	Shared Neighborhood Hits	54
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

CNKR2_HUMAN
θ value	9.29e-05 (rank : 37)	NC score	0.263060 (rank : 42)
Query Neighborhood Hits	135	Target Neighborhood Hits	197	Shared Neighborhood Hits	59
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	9.29e-05 (rank : 38)	NC score	0.263260 (rank : 41)
Query Neighborhood Hits	135	Target Neighborhood Hits	197	Shared Neighborhood Hits	59
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

PLEK2_HUMAN
θ value	9.29e-05 (rank : 39)	NC score	0.331024 (rank : 33)
Query Neighborhood Hits	135	Target Neighborhood Hits	101	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	9.29e-05 (rank : 40)	NC score	0.331814 (rank : 32)
Query Neighborhood Hits	135	Target Neighborhood Hits	96	Shared Neighborhood Hits	69
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PKHA2_MOUSE
θ value	0.000121331 (rank : 41)	NC score	0.340638 (rank : 30)
Query Neighborhood Hits	135	Target Neighborhood Hits	116	Shared Neighborhood Hits	75
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

CENB2_HUMAN
θ value	0.000158464 (rank : 42)	NC score	0.167103 (rank : 51)
Query Neighborhood Hits	135	Target Neighborhood Hits	425	Shared Neighborhood Hits	57
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	0.000158464 (rank : 43)	NC score	0.156075 (rank : 56)
Query Neighborhood Hits	135	Target Neighborhood Hits	395	Shared Neighborhood Hits	62
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

PKHA4_MOUSE
θ value	0.000461057 (rank : 44)	NC score	0.336442 (rank : 31)
Query Neighborhood Hits	135	Target Neighborhood Hits	202	Shared Neighborhood Hits	68
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

GNRP_MOUSE
θ value	0.000602161 (rank : 45)	NC score	0.158436 (rank : 54)
Query Neighborhood Hits	135	Target Neighborhood Hits	191	Shared Neighborhood Hits	51
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

PKHA5_HUMAN
θ value	0.000602161 (rank : 46)	NC score	0.286569 (rank : 38)
Query Neighborhood Hits	135	Target Neighborhood Hits	455	Shared Neighborhood Hits	86
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

3BP2_HUMAN
θ value	0.00102713 (rank : 47)	NC score	0.268114 (rank : 40)
Query Neighborhood Hits	135	Target Neighborhood Hits	296	Shared Neighborhood Hits	41
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ANLN_MOUSE
θ value	0.00102713 (rank : 48)	NC score	0.202910 (rank : 46)
Query Neighborhood Hits	135	Target Neighborhood Hits	297	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

3BP2_MOUSE
θ value	0.00134147 (rank : 49)	NC score	0.275152 (rank : 39)
Query Neighborhood Hits	135	Target Neighborhood Hits	142	Shared Neighborhood Hits	38
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ANLN_HUMAN
θ value	0.00134147 (rank : 50)	NC score	0.236775 (rank : 43)
Query Neighborhood Hits	135	Target Neighborhood Hits	222	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

PKHA4_HUMAN
θ value	0.00134147 (rank : 51)	NC score	0.315710 (rank : 35)
Query Neighborhood Hits	135	Target Neighborhood Hits	283	Shared Neighborhood Hits	69
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

OSBP1_HUMAN
θ value	0.00175202 (rank : 52)	NC score	0.156448 (rank : 55)
Query Neighborhood Hits	135	Target Neighborhood Hits	180	Shared Neighborhood Hits	63
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

PHLB1_MOUSE
θ value	0.00228821 (rank : 53)	NC score	0.146443 (rank : 59)
Query Neighborhood Hits	135	Target Neighborhood Hits	678	Shared Neighborhood Hits	53
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

MTMR5_HUMAN
θ value	0.00298849 (rank : 54)	NC score	0.146922 (rank : 58)
Query Neighborhood Hits	135	Target Neighborhood Hits	141	Shared Neighborhood Hits	49
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

MYO10_HUMAN
θ value	0.00298849 (rank : 55)	NC score	0.094228 (rank : 88)
Query Neighborhood Hits	135	Target Neighborhood Hits	920	Shared Neighborhood Hits	81
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

OSBP2_HUMAN
θ value	0.00298849 (rank : 56)	NC score	0.126123 (rank : 69)
Query Neighborhood Hits	135	Target Neighborhood Hits	154	Shared Neighborhood Hits	57
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

PHLB2_MOUSE
θ value	0.00298849 (rank : 57)	NC score	0.130992 (rank : 63)
Query Neighborhood Hits	135	Target Neighborhood Hits	1016	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_HUMAN
θ value	0.00390308 (rank : 58)	NC score	0.130871 (rank : 64)
Query Neighborhood Hits	135	Target Neighborhood Hits	964	Shared Neighborhood Hits	54
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PKHA2_HUMAN
θ value	0.00390308 (rank : 59)	NC score	0.320548 (rank : 34)
Query Neighborhood Hits	135	Target Neighborhood Hits	119	Shared Neighborhood Hits	74
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

OSBL8_HUMAN
θ value	0.00665767 (rank : 60)	NC score	0.144098 (rank : 60)
Query Neighborhood Hits	135	Target Neighborhood Hits	289	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

PHLB1_HUMAN
θ value	0.0193708 (rank : 61)	NC score	0.133129 (rank : 61)
Query Neighborhood Hits	135	Target Neighborhood Hits	1038	Shared Neighborhood Hits	54
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

MTMRD_HUMAN
θ value	0.0252991 (rank : 62)	NC score	0.127041 (rank : 68)
Query Neighborhood Hits	135	Target Neighborhood Hits	135	Shared Neighborhood Hits	61
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

OSB11_HUMAN
θ value	0.0330416 (rank : 63)	NC score	0.115521 (rank : 77)
Query Neighborhood Hits	135	Target Neighborhood Hits	60	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB11_MOUSE
θ value	0.0330416 (rank : 64)	NC score	0.115917 (rank : 76)
Query Neighborhood Hits	135	Target Neighborhood Hits	71	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

CENB1_HUMAN
θ value	0.0431538 (rank : 65)	NC score	0.125932 (rank : 70)
Query Neighborhood Hits	135	Target Neighborhood Hits	383	Shared Neighborhood Hits	53
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

FGD6_MOUSE
θ value	0.0431538 (rank : 66)	NC score	0.094194 (rank : 89)
Query Neighborhood Hits	135	Target Neighborhood Hits	282	Shared Neighborhood Hits	55
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

AKT1_HUMAN
θ value	0.0563607 (rank : 67)	NC score	0.034922 (rank : 136)
Query Neighborhood Hits	135	Target Neighborhood Hits	885	Shared Neighborhood Hits	50
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT2_HUMAN
θ value	0.0563607 (rank : 68)	NC score	0.038190 (rank : 133)
Query Neighborhood Hits	135	Target Neighborhood Hits	878	Shared Neighborhood Hits	45
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
θ value	0.0563607 (rank : 69)	NC score	0.038044 (rank : 134)
Query Neighborhood Hits	135	Target Neighborhood Hits	875	Shared Neighborhood Hits	42
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT1_MOUSE
θ value	0.0736092 (rank : 70)	NC score	0.034307 (rank : 137)
Query Neighborhood Hits	135	Target Neighborhood Hits	878	Shared Neighborhood Hits	49
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

DYN2_HUMAN
θ value	0.0736092 (rank : 71)	NC score	0.127881 (rank : 66)
Query Neighborhood Hits	135	Target Neighborhood Hits	112	Shared Neighborhood Hits	34
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
θ value	0.0736092 (rank : 72)	NC score	0.127869 (rank : 67)
Query Neighborhood Hits	135	Target Neighborhood Hits	104	Shared Neighborhood Hits	34
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

DYN3_HUMAN
θ value	0.0736092 (rank : 73)	NC score	0.128241 (rank : 65)
Query Neighborhood Hits	135	Target Neighborhood Hits	158	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

OSBL5_HUMAN
θ value	0.0736092 (rank : 74)	NC score	0.118600 (rank : 75)
Query Neighborhood Hits	135	Target Neighborhood Hits	117	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

OSBL5_MOUSE
θ value	0.0736092 (rank : 75)	NC score	0.121167 (rank : 73)
Query Neighborhood Hits	135	Target Neighborhood Hits	77	Shared Neighborhood Hits	23
SwissProt Accessions	Q9ER64, Q8R510, Q99NF5	Gene names	Osbpl5, Obph1, Osbp2
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5) (Oxysterol-binding protein homolog 1).

OSBL9_HUMAN
θ value	0.0961366 (rank : 76)	NC score	0.132484 (rank : 62)
Query Neighborhood Hits	135	Target Neighborhood Hits	138	Shared Neighborhood Hits	56
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

TARA_MOUSE
θ value	0.0961366 (rank : 77)	NC score	0.093400 (rank : 91)
Query Neighborhood Hits	135	Target Neighborhood Hits	1133	Shared Neighborhood Hits	64
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

FGD6_HUMAN
θ value	0.125558 (rank : 78)	NC score	0.095955 (rank : 85)
Query Neighborhood Hits	135	Target Neighborhood Hits	237	Shared Neighborhood Hits	55
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

OSB10_HUMAN
θ value	0.163984 (rank : 79)	NC score	0.107736 (rank : 79)
Query Neighborhood Hits	135	Target Neighborhood Hits	55	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

PKHB1_HUMAN
θ value	0.163984 (rank : 80)	NC score	0.154485 (rank : 57)
Query Neighborhood Hits	135	Target Neighborhood Hits	46	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

TARA_HUMAN
θ value	0.163984 (rank : 81)	NC score	0.068418 (rank : 114)
Query Neighborhood Hits	135	Target Neighborhood Hits	1626	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

AKT3_HUMAN
θ value	0.279714 (rank : 82)	NC score	0.030290 (rank : 138)
Query Neighborhood Hits	135	Target Neighborhood Hits	872	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	0.279714 (rank : 83)	NC score	0.030285 (rank : 139)
Query Neighborhood Hits	135	Target Neighborhood Hits	872	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

RASA1_HUMAN
θ value	0.279714 (rank : 84)	NC score	0.174929 (rank : 49)
Query Neighborhood Hits	135	Target Neighborhood Hits	258	Shared Neighborhood Hits	50
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

FARP2_MOUSE
θ value	0.365318 (rank : 85)	NC score	0.088438 (rank : 97)
Query Neighborhood Hits	135	Target Neighborhood Hits	209	Shared Neighborhood Hits	52
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PKHB1_MOUSE
θ value	0.365318 (rank : 86)	NC score	0.124618 (rank : 71)
Query Neighborhood Hits	135	Target Neighborhood Hits	47	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

FGD4_HUMAN
θ value	0.47712 (rank : 87)	NC score	0.078814 (rank : 103)
Query Neighborhood Hits	135	Target Neighborhood Hits	219	Shared Neighborhood Hits	41
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

OSBP2_MOUSE
θ value	0.47712 (rank : 88)	NC score	0.093902 (rank : 90)
Query Neighborhood Hits	135	Target Neighborhood Hits	150	Shared Neighborhood Hits	49
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

FARP2_HUMAN
θ value	0.62314 (rank : 89)	NC score	0.079396 (rank : 101)
Query Neighborhood Hits	135	Target Neighborhood Hits	240	Shared Neighborhood Hits	44
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

RASA3_HUMAN
θ value	0.62314 (rank : 90)	NC score	0.095166 (rank : 86)
Query Neighborhood Hits	135	Target Neighborhood Hits	166	Shared Neighborhood Hits	41
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

GRB7_HUMAN
θ value	0.813845 (rank : 91)	NC score	0.068689 (rank : 113)
Query Neighborhood Hits	135	Target Neighborhood Hits	156	Shared Neighborhood Hits	21
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

PKHB2_HUMAN
θ value	0.813845 (rank : 92)	NC score	0.166475 (rank : 52)
Query Neighborhood Hits	135	Target Neighborhood Hits	54	Shared Neighborhood Hits	46
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHF2_MOUSE
θ value	1.06291 (rank : 93)	NC score	0.055470 (rank : 122)
Query Neighborhood Hits	135	Target Neighborhood Hits	77	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

TBCD2_HUMAN
θ value	1.06291 (rank : 94)	NC score	0.113462 (rank : 78)
Query Neighborhood Hits	135	Target Neighborhood Hits	419	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

CAPS2_HUMAN
θ value	1.38821 (rank : 95)	NC score	0.059812 (rank : 119)
Query Neighborhood Hits	135	Target Neighborhood Hits	81	Shared Neighborhood Hits	27
SwissProt Accessions	Q86UW7, Q658Q2, Q7Z5T7, Q8IZW9, Q8N7M4, Q9H6P4, Q9HCI1, Q9NWK8	Gene names	CADPS2, CAPS2, KIAA1591
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

CAPS2_MOUSE
θ value	1.38821 (rank : 96)	NC score	0.052837 (rank : 124)
Query Neighborhood Hits	135	Target Neighborhood Hits	78	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BYR5, O08903, Q66JM7, Q6PCL7, Q76I88, Q7TMM6, Q80ZV8, Q8BL25, Q8BY04, Q8K3K6	Gene names	Cadps2, Caps2
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

FGD2_MOUSE
θ value	1.38821 (rank : 97)	NC score	0.057928 (rank : 120)
Query Neighborhood Hits	135	Target Neighborhood Hits	163	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD4_MOUSE
θ value	1.38821 (rank : 98)	NC score	0.077417 (rank : 105)
Query Neighborhood Hits	135	Target Neighborhood Hits	227	Shared Neighborhood Hits	41
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

MRIP_MOUSE
θ value	1.38821 (rank : 99)	NC score	0.092951 (rank : 92)
Query Neighborhood Hits	135	Target Neighborhood Hits	569	Shared Neighborhood Hits	65
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

PKHB2_MOUSE
θ value	1.38821 (rank : 100)	NC score	0.168099 (rank : 50)
Query Neighborhood Hits	135	Target Neighborhood Hits	48	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHF2_HUMAN
θ value	1.81305 (rank : 101)	NC score	0.047114 (rank : 130)
Query Neighborhood Hits	135	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

TEC_HUMAN
θ value	1.81305 (rank : 102)	NC score	0.023427 (rank : 140)
Query Neighborhood Hits	135	Target Neighborhood Hits	1006	Shared Neighborhood Hits	30
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

AB1IP_HUMAN
θ value	2.36792 (rank : 103)	NC score	0.081233 (rank : 99)
Query Neighborhood Hits	135	Target Neighborhood Hits	213	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

AB1IP_MOUSE
θ value	2.36792 (rank : 104)	NC score	0.063961 (rank : 115)
Query Neighborhood Hits	135	Target Neighborhood Hits	181	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

CEND3_HUMAN
θ value	2.36792 (rank : 105)	NC score	0.069088 (rank : 112)
Query Neighborhood Hits	135	Target Neighborhood Hits	275	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

FARP1_HUMAN
θ value	2.36792 (rank : 106)	NC score	0.092154 (rank : 93)
Query Neighborhood Hits	135	Target Neighborhood Hits	241	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FGD2_HUMAN
θ value	2.36792 (rank : 107)	NC score	0.060532 (rank : 117)
Query Neighborhood Hits	135	Target Neighborhood Hits	151	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

PKHA3_HUMAN
θ value	2.36792 (rank : 108)	NC score	0.120341 (rank : 74)
Query Neighborhood Hits	135	Target Neighborhood Hits	66	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_MOUSE
θ value	2.36792 (rank : 109)	NC score	0.123037 (rank : 72)
Query Neighborhood Hits	135	Target Neighborhood Hits	67	Shared Neighborhood Hits	45
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

CENA1_HUMAN
θ value	3.0926 (rank : 110)	NC score	0.100862 (rank : 81)
Query Neighborhood Hits	135	Target Neighborhood Hits	87	Shared Neighborhood Hits	44
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

DYN1_HUMAN
θ value	3.0926 (rank : 111)	NC score	0.099932 (rank : 83)
Query Neighborhood Hits	135	Target Neighborhood Hits	216	Shared Neighborhood Hits	27
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_MOUSE
θ value	3.0926 (rank : 112)	NC score	0.100229 (rank : 82)
Query Neighborhood Hits	135	Target Neighborhood Hits	168	Shared Neighborhood Hits	26
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

FGD5_MOUSE
θ value	3.0926 (rank : 113)	NC score	0.079798 (rank : 100)
Query Neighborhood Hits	135	Target Neighborhood Hits	170	Shared Neighborhood Hits	39
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

MY18A_MOUSE
θ value	3.0926 (rank : 114)	NC score	0.006298 (rank : 147)
Query Neighborhood Hits	135	Target Neighborhood Hits	1989	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

OSBL3_HUMAN
θ value	3.0926 (rank : 115)	NC score	0.095139 (rank : 87)
Query Neighborhood Hits	135	Target Neighborhood Hits	93	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

CENA2_HUMAN
θ value	4.03905 (rank : 116)	NC score	0.107012 (rank : 80)
Query Neighborhood Hits	135	Target Neighborhood Hits	83	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

DGKH_HUMAN
θ value	4.03905 (rank : 117)	NC score	0.091585 (rank : 94)
Query Neighborhood Hits	135	Target Neighborhood Hits	255	Shared Neighborhood Hits	63
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DZIP1_MOUSE
θ value	4.03905 (rank : 118)	NC score	0.009032 (rank : 145)
Query Neighborhood Hits	135	Target Neighborhood Hits	530	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BMD2, Q6ZQ10, Q9CRK5	Gene names	Dzip1, Kiaa0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1 homolog).

MYST4_HUMAN
θ value	4.03905 (rank : 119)	NC score	0.009037 (rank : 144)
Query Neighborhood Hits	135	Target Neighborhood Hits	671	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

OSBL3_MOUSE
θ value	4.03905 (rank : 120)	NC score	0.089856 (rank : 96)
Query Neighborhood Hits	135	Target Neighborhood Hits	86	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

RASA3_MOUSE
θ value	4.03905 (rank : 121)	NC score	0.085107 (rank : 98)
Query Neighborhood Hits	135	Target Neighborhood Hits	144	Shared Neighborhood Hits	38
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

VASP_HUMAN
θ value	4.03905 (rank : 122)	NC score	0.013673 (rank : 141)
Query Neighborhood Hits	135	Target Neighborhood Hits	201	Shared Neighborhood Hits	6
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

CAPS1_HUMAN
θ value	5.27518 (rank : 123)	NC score	0.038685 (rank : 132)
Query Neighborhood Hits	135	Target Neighborhood Hits	86	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ULU8, Q13339, Q6GQQ6, Q8N2Z5, Q8N3M7, Q8NFR0, Q96BC2	Gene names	CADPS, CAPS, CAPS1, KIAA1121
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1).

CAPS1_MOUSE
θ value	5.27518 (rank : 124)	NC score	0.038869 (rank : 131)
Query Neighborhood Hits	135	Target Neighborhood Hits	93	Shared Neighborhood Hits	20
SwissProt Accessions	Q80TJ1, Q3TSP2, Q61374, Q6AXB4, Q6PGF0	Gene names	Cadps, Caps, Caps1, Kiaa1121
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1).

CEND1_HUMAN
θ value	5.27518 (rank : 125)	NC score	0.078699 (rank : 104)
Query Neighborhood Hits	135	Target Neighborhood Hits	284	Shared Neighborhood Hits	69
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

GRB10_MOUSE
θ value	5.27518 (rank : 126)	NC score	0.047511 (rank : 129)
Query Neighborhood Hits	135	Target Neighborhood Hits	156	Shared Neighborhood Hits	17
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_MOUSE
θ value	5.27518 (rank : 127)	NC score	0.034989 (rank : 135)
Query Neighborhood Hits	135	Target Neighborhood Hits	149	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

MYST4_MOUSE
θ value	5.27518 (rank : 128)	NC score	0.006102 (rank : 148)
Query Neighborhood Hits	135	Target Neighborhood Hits	416	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

LAMB1_MOUSE
θ value	6.88961 (rank : 129)	NC score	0.002538 (rank : 150)
Query Neighborhood Hits	135	Target Neighborhood Hits	919	Shared Neighborhood Hits	12
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

MRIP_HUMAN
θ value	6.88961 (rank : 130)	NC score	0.079173 (rank : 102)
Query Neighborhood Hits	135	Target Neighborhood Hits	578	Shared Neighborhood Hits	63
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

SMC3_HUMAN
θ value	6.88961 (rank : 131)	NC score	0.009719 (rank : 143)
Query Neighborhood Hits	135	Target Neighborhood Hits	1186	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	6.88961 (rank : 132)	NC score	0.009815 (rank : 142)
Query Neighborhood Hits	135	Target Neighborhood Hits	1187	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

CEND3_MOUSE
θ value	8.99809 (rank : 133)	NC score	0.062210 (rank : 116)
Query Neighborhood Hits	135	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

LAMB1_HUMAN
θ value	8.99809 (rank : 134)	NC score	0.002846 (rank : 149)
Query Neighborhood Hits	135	Target Neighborhood Hits	1018	Shared Neighborhood Hits	14
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

VASP_MOUSE
θ value	8.99809 (rank : 135)	NC score	0.006400 (rank : 146)
Query Neighborhood Hits	135	Target Neighborhood Hits	195	Shared Neighborhood Hits	3
SwissProt Accessions	P70460, Q3TAP0, Q3TCD2, Q3U0C2, Q3UDF1, Q91VD2, Q9R214	Gene names	Vasp
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

C43BP_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.090353 (rank : 95)
Query Neighborhood Hits	135	Target Neighborhood Hits	87	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.096610 (rank : 84)
Query Neighborhood Hits	135	Target Neighborhood Hits	91	Shared Neighborhood Hits	54
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CENA2_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.057866 (rank : 121)
Query Neighborhood Hits	135	Target Neighborhood Hits	68	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

CEND1_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.051944 (rank : 125)
Query Neighborhood Hits	135	Target Neighborhood Hits	260	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND2_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.073101 (rank : 109)
Query Neighborhood Hits	135	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

FGD1_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.050007 (rank : 128)
Query Neighborhood Hits	135	Target Neighborhood Hits	367	Shared Neighborhood Hits	34
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.050684 (rank : 127)
Query Neighborhood Hits	135	Target Neighborhood Hits	387	Shared Neighborhood Hits	32
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.053406 (rank : 123)
Query Neighborhood Hits	135	Target Neighborhood Hits	257	Shared Neighborhood Hits	30
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD5_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.072461 (rank : 110)
Query Neighborhood Hits	135	Target Neighborhood Hits	235	Shared Neighborhood Hits	46
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

GAB1_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.076002 (rank : 106)
Query Neighborhood Hits	135	Target Neighborhood Hits	279	Shared Neighborhood Hits	42
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB1_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.069618 (rank : 111)
Query Neighborhood Hits	135	Target Neighborhood Hits	233	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB2_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.075995 (rank : 107)
Query Neighborhood Hits	135	Target Neighborhood Hits	188	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GAB2_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.074360 (rank : 108)
Query Neighborhood Hits	135	Target Neighborhood Hits	220	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

OSBL2_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.051669 (rank : 126)
Query Neighborhood Hits	135	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H1P3, Q9BZB1, Q9Y4B8	Gene names	OSBPL2, KIAA0772, ORP2
Domain Architecture
Description	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2).

OSBL7_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.060321 (rank : 118)
Query Neighborhood Hits	135	Target Neighborhood Hits	71	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

Hits sorted by NC score

CYH4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	135	Target Neighborhood Hits	135	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
NC score	0.998812 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	135	Target Neighborhood Hits	134	Shared Neighborhood Hits	125
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH3_MOUSE
NC score	0.991275 (rank : 3)	θ value	3.36238e-172 (rank : 3)
Query Neighborhood Hits	135	Target Neighborhood Hits	148	Shared Neighborhood Hits	120
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH3_HUMAN
NC score	0.988996 (rank : 4)	θ value	8.28183e-171 (rank : 4)
Query Neighborhood Hits	135	Target Neighborhood Hits	137	Shared Neighborhood Hits	113
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH2_MOUSE
NC score	0.988853 (rank : 5)	θ value	2.11095e-166 (rank : 5)
Query Neighborhood Hits	135	Target Neighborhood Hits	171	Shared Neighborhood Hits	117
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.988751 (rank : 6)	θ value	5.19945e-165 (rank : 6)
Query Neighborhood Hits	135	Target Neighborhood Hits	175	Shared Neighborhood Hits	117
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH1_MOUSE
NC score	0.986157 (rank : 7)	θ value	3.72618e-163 (rank : 8)
Query Neighborhood Hits	135	Target Neighborhood Hits	176	Shared Neighborhood Hits	116
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH1_HUMAN
NC score	0.985918 (rank : 8)	θ value	3.37019e-164 (rank : 7)
Query Neighborhood Hits	135	Target Neighborhood Hits	184	Shared Neighborhood Hits	116
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

BIG1_HUMAN
NC score	0.822585 (rank : 9)	θ value	4.122e-45 (rank : 9)
Query Neighborhood Hits	135	Target Neighborhood Hits	76	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BIG2_HUMAN
NC score	0.818462 (rank : 10)	θ value	6.58091e-43 (rank : 10)
Query Neighborhood Hits	135	Target Neighborhood Hits	66	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

GBF1_HUMAN
NC score	0.810015 (rank : 11)	θ value	4.72714e-33 (rank : 14)
Query Neighborhood Hits	135	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

IQEC3_HUMAN
NC score	0.798601 (rank : 12)	θ value	8.91499e-32 (rank : 17)
Query Neighborhood Hits	135	Target Neighborhood Hits	125	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC1_MOUSE
NC score	0.791305 (rank : 13)	θ value	1.46948e-34 (rank : 12)
Query Neighborhood Hits	135	Target Neighborhood Hits	54	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

IQEC1_HUMAN
NC score	0.790403 (rank : 14)	θ value	5.0505e-35 (rank : 11)
Query Neighborhood Hits	135	Target Neighborhood Hits	76	Shared Neighborhood Hits	25
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC3_MOUSE
NC score	0.790345 (rank : 15)	θ value	2.34606e-32 (rank : 16)
Query Neighborhood Hits	135	Target Neighborhood Hits	274	Shared Neighborhood Hits	28
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

PSD3_HUMAN
NC score	0.763484 (rank : 16)	θ value	8.65492e-19 (rank : 20)
Query Neighborhood Hits	135	Target Neighborhood Hits	75	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

FBX8_MOUSE
NC score	0.756327 (rank : 17)	θ value	2.13179e-17 (rank : 21)
Query Neighborhood Hits	135	Target Neighborhood Hits	45	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FBX8_HUMAN
NC score	0.754188 (rank : 18)	θ value	2.7842e-17 (rank : 22)
Query Neighborhood Hits	135	Target Neighborhood Hits	44	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

IQEC2_MOUSE
NC score	0.742977 (rank : 19)	θ value	3.61944e-33 (rank : 13)
Query Neighborhood Hits	135	Target Neighborhood Hits	417	Shared Neighborhood Hits	25
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_HUMAN
NC score	0.742791 (rank : 20)	θ value	6.17384e-33 (rank : 15)
Query Neighborhood Hits	135	Target Neighborhood Hits	403	Shared Neighborhood Hits	25
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

PSD4_MOUSE
NC score	0.719851 (rank : 21)	θ value	1.42661e-21 (rank : 18)
Query Neighborhood Hits	135	Target Neighborhood Hits	78	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

PSD4_HUMAN
NC score	0.713559 (rank : 22)	θ value	4.15078e-21 (rank : 19)
Query Neighborhood Hits	135	Target Neighborhood Hits	178	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

CNKR1_HUMAN
NC score	0.401760 (rank : 23)	θ value	4.92598e-06 (rank : 30)
Query Neighborhood Hits	135	Target Neighborhood Hits	154	Shared Neighborhood Hits	60
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

PKHA1_HUMAN
NC score	0.380469 (rank : 24)	θ value	1.09739e-05 (rank : 31)
Query Neighborhood Hits	135	Target Neighborhood Hits	127	Shared Neighborhood Hits	74
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.379222 (rank : 25)	θ value	1.09739e-05 (rank : 32)
Query Neighborhood Hits	135	Target Neighborhood Hits	120	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PLEK_HUMAN
NC score	0.378838 (rank : 26)	θ value	2.21117e-06 (rank : 27)
Query Neighborhood Hits	135	Target Neighborhood Hits	110	Shared Neighborhood Hits	75
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
NC score	0.377499 (rank : 27)	θ value	1.29631e-06 (rank : 23)
Query Neighborhood Hits	135	Target Neighborhood Hits	109	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PKHA6_HUMAN
NC score	0.370771 (rank : 28)	θ value	1.69304e-06 (rank : 25)
Query Neighborhood Hits	135	Target Neighborhood Hits	556	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.359133 (rank : 29)	θ value	3.77169e-06 (rank : 29)
Query Neighborhood Hits	135	Target Neighborhood Hits	591	Shared Neighborhood Hits	97
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA2_MOUSE
NC score	0.340638 (rank : 30)	θ value	0.000121331 (rank : 41)
Query Neighborhood Hits	135	Target Neighborhood Hits	116	Shared Neighborhood Hits	75
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA4_MOUSE
NC score	0.336442 (rank : 31)	θ value	0.000461057 (rank : 44)
Query Neighborhood Hits	135	Target Neighborhood Hits	202	Shared Neighborhood Hits	68
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PLEK2_MOUSE
NC score	0.331814 (rank : 32)	θ value	9.29e-05 (rank : 40)
Query Neighborhood Hits	135	Target Neighborhood Hits	96	Shared Neighborhood Hits	69
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_HUMAN
NC score	0.331024 (rank : 33)	θ value	9.29e-05 (rank : 39)
Query Neighborhood Hits	135	Target Neighborhood Hits	101	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PKHA2_HUMAN
NC score	0.320548 (rank : 34)	θ value	0.00390308 (rank : 59)
Query Neighborhood Hits	135	Target Neighborhood Hits	119	Shared Neighborhood Hits	74
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA4_HUMAN
NC score	0.315710 (rank : 35)	θ value	0.00134147 (rank : 51)
Query Neighborhood Hits	135	Target Neighborhood Hits	283	Shared Neighborhood Hits	69
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

DAPP1_MOUSE
NC score	0.307421 (rank : 36)	θ value	2.21117e-06 (rank : 26)
Query Neighborhood Hits	135	Target Neighborhood Hits	225	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_HUMAN
NC score	0.296680 (rank : 37)	θ value	3.77169e-06 (rank : 28)
Query Neighborhood Hits	135	Target Neighborhood Hits	227	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA5_HUMAN
NC score	0.286569 (rank : 38)	θ value	0.000602161 (rank : 46)
Query Neighborhood Hits	135	Target Neighborhood Hits	455	Shared Neighborhood Hits	86
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

3BP2_MOUSE
NC score	0.275152 (rank : 39)	θ value	0.00134147 (rank : 49)
Query Neighborhood Hits	135	Target Neighborhood Hits	142	Shared Neighborhood Hits	38
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_HUMAN
NC score	0.268114 (rank : 40)	θ value	0.00102713 (rank : 47)
Query Neighborhood Hits	135	Target Neighborhood Hits	296	Shared Neighborhood Hits	41
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CNKR2_MOUSE
NC score	0.263260 (rank : 41)	θ value	9.29e-05 (rank : 38)
Query Neighborhood Hits	135	Target Neighborhood Hits	197	Shared Neighborhood Hits	59
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.263060 (rank : 42)	θ value	9.29e-05 (rank : 37)
Query Neighborhood Hits	135	Target Neighborhood Hits	197	Shared Neighborhood Hits	59
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ANLN_HUMAN
NC score	0.236775 (rank : 43)	θ value	0.00134147 (rank : 50)
Query Neighborhood Hits	135	Target Neighborhood Hits	222	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

RHG25_MOUSE
NC score	0.224886 (rank : 44)	θ value	1.09739e-05 (rank : 33)
Query Neighborhood Hits	135	Target Neighborhood Hits	492	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_HUMAN
NC score	0.221948 (rank : 45)	θ value	2.44474e-05 (rank : 35)
Query Neighborhood Hits	135	Target Neighborhood Hits	550	Shared Neighborhood Hits	94
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

ANLN_MOUSE
NC score	0.202910 (rank : 46)	θ value	0.00102713 (rank : 48)
Query Neighborhood Hits	135	Target Neighborhood Hits	297	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

SWP70_HUMAN
NC score	0.194178 (rank : 47)	θ value	1.29631e-06 (rank : 24)
Query Neighborhood Hits	135	Target Neighborhood Hits	973	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
NC score	0.179463 (rank : 48)	θ value	1.87187e-05 (rank : 34)
Query Neighborhood Hits	135	Target Neighborhood Hits	1097	Shared Neighborhood Hits	85
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

RASA1_HUMAN
NC score	0.174929 (rank : 49)	θ value	0.279714 (rank : 84)
Query Neighborhood Hits	135	Target Neighborhood Hits	258	Shared Neighborhood Hits	50
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

PKHB2_MOUSE
NC score	0.168099 (rank : 50)	θ value	1.38821 (rank : 100)
Query Neighborhood Hits	135	Target Neighborhood Hits	48	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

CENB2_HUMAN
NC score	0.167103 (rank : 51)	θ value	0.000158464 (rank : 42)
Query Neighborhood Hits	135	Target Neighborhood Hits	425	Shared Neighborhood Hits	57
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

PKHB2_HUMAN
NC score	0.166475 (rank : 52)	θ value	0.813845 (rank : 92)
Query Neighborhood Hits	135	Target Neighborhood Hits	54	Shared Neighborhood Hits	46
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

GNRP_HUMAN
NC score	0.163528 (rank : 53)	θ value	4.1701e-05 (rank : 36)
Query Neighborhood Hits	135	Target Neighborhood Hits	239	Shared Neighborhood Hits	54
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
NC score	0.158436 (rank : 54)	θ value	0.000602161 (rank : 45)
Query Neighborhood Hits	135	Target Neighborhood Hits	191	Shared Neighborhood Hits	51
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

OSBP1_HUMAN
NC score	0.156448 (rank : 55)	θ value	0.00175202 (rank : 52)
Query Neighborhood Hits	135	Target Neighborhood Hits	180	Shared Neighborhood Hits	63
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

CENB5_HUMAN
NC score	0.156075 (rank : 56)	θ value	0.000158464 (rank : 43)
Query Neighborhood Hits	135	Target Neighborhood Hits	395	Shared Neighborhood Hits	62
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

PKHB1_HUMAN
NC score	0.154485 (rank : 57)	θ value	0.163984 (rank : 80)
Query Neighborhood Hits	135	Target Neighborhood Hits	46	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

MTMR5_HUMAN
NC score	0.146922 (rank : 58)	θ value	0.00298849 (rank : 54)
Query Neighborhood Hits	135	Target Neighborhood Hits	141	Shared Neighborhood Hits	49
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

PHLB1_MOUSE
NC score	0.146443 (rank : 59)	θ value	0.00228821 (rank : 53)
Query Neighborhood Hits	135	Target Neighborhood Hits	678	Shared Neighborhood Hits	53
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

OSBL8_HUMAN
NC score	0.144098 (rank : 60)	θ value	0.00665767 (rank : 60)
Query Neighborhood Hits	135	Target Neighborhood Hits	289	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

PHLB1_HUMAN
NC score	0.133129 (rank : 61)	θ value	0.0193708 (rank : 61)
Query Neighborhood Hits	135	Target Neighborhood Hits	1038	Shared Neighborhood Hits	54
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

OSBL9_HUMAN
NC score	0.132484 (rank : 62)	θ value	0.0961366 (rank : 76)
Query Neighborhood Hits	135	Target Neighborhood Hits	138	Shared Neighborhood Hits	56
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PHLB2_MOUSE
NC score	0.130992 (rank : 63)	θ value	0.00298849 (rank : 57)
Query Neighborhood Hits	135	Target Neighborhood Hits	1016	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_HUMAN
NC score	0.130871 (rank : 64)	θ value	0.00390308 (rank : 58)
Query Neighborhood Hits	135	Target Neighborhood Hits	964	Shared Neighborhood Hits	54
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

DYN3_HUMAN
NC score	0.128241 (rank : 65)	θ value	0.0736092 (rank : 73)
Query Neighborhood Hits	135	Target Neighborhood Hits	158	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

DYN2_HUMAN
NC score	0.127881 (rank : 66)	θ value	0.0736092 (rank : 71)
Query Neighborhood Hits	135	Target Neighborhood Hits	112	Shared Neighborhood Hits	34
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
NC score	0.127869 (rank : 67)	θ value	0.0736092 (rank : 72)
Query Neighborhood Hits	135	Target Neighborhood Hits	104	Shared Neighborhood Hits	34
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

MTMRD_HUMAN
NC score	0.127041 (rank : 68)	θ value	0.0252991 (rank : 62)
Query Neighborhood Hits	135	Target Neighborhood Hits	135	Shared Neighborhood Hits	61
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

OSBP2_HUMAN
NC score	0.126123 (rank : 69)	θ value	0.00298849 (rank : 56)
Query Neighborhood Hits	135	Target Neighborhood Hits	154	Shared Neighborhood Hits	57
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

CENB1_HUMAN
NC score	0.125932 (rank : 70)	θ value	0.0431538 (rank : 65)
Query Neighborhood Hits	135	Target Neighborhood Hits	383	Shared Neighborhood Hits	53
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

PKHB1_MOUSE
NC score	0.124618 (rank : 71)	θ value	0.365318 (rank : 86)
Query Neighborhood Hits	135	Target Neighborhood Hits	47	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHA3_MOUSE
NC score	0.123037 (rank : 72)	θ value	2.36792 (rank : 109)
Query Neighborhood Hits	135	Target Neighborhood Hits	67	Shared Neighborhood Hits	45
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

OSBL5_MOUSE
NC score	0.121167 (rank : 73)	θ value	0.0736092 (rank : 75)
Query Neighborhood Hits	135	Target Neighborhood Hits	77	Shared Neighborhood Hits	23
SwissProt Accessions	Q9ER64, Q8R510, Q99NF5	Gene names	Osbpl5, Obph1, Osbp2
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5) (Oxysterol-binding protein homolog 1).

PKHA3_HUMAN
NC score	0.120341 (rank : 74)	θ value	2.36792 (rank : 108)
Query Neighborhood Hits	135	Target Neighborhood Hits	66	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

OSBL5_HUMAN
NC score	0.118600 (rank : 75)	θ value	0.0736092 (rank : 74)
Query Neighborhood Hits	135	Target Neighborhood Hits	117	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

OSB11_MOUSE
NC score	0.115917 (rank : 76)	θ value	0.0330416 (rank : 64)
Query Neighborhood Hits	135	Target Neighborhood Hits	71	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB11_HUMAN
NC score	0.115521 (rank : 77)	θ value	0.0330416 (rank : 63)
Query Neighborhood Hits	135	Target Neighborhood Hits	60	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

TBCD2_HUMAN
NC score	0.113462 (rank : 78)	θ value	1.06291 (rank : 94)
Query Neighborhood Hits	135	Target Neighborhood Hits	419	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

OSB10_HUMAN
NC score	0.107736 (rank : 79)	θ value	0.163984 (rank : 79)
Query Neighborhood Hits	135	Target Neighborhood Hits	55	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

CENA2_HUMAN
NC score	0.107012 (rank : 80)	θ value	4.03905 (rank : 116)
Query Neighborhood Hits	135	Target Neighborhood Hits	83	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENA1_HUMAN
NC score	0.100862 (rank : 81)	θ value	3.0926 (rank : 110)
Query Neighborhood Hits	135	Target Neighborhood Hits	87	Shared Neighborhood Hits	44
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

DYN1_MOUSE
NC score	0.100229 (rank : 82)	θ value	3.0926 (rank : 112)
Query Neighborhood Hits	135	Target Neighborhood Hits	168	Shared Neighborhood Hits	26
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_HUMAN
NC score	0.099932 (rank : 83)	θ value	3.0926 (rank : 111)
Query Neighborhood Hits	135	Target Neighborhood Hits	216	Shared Neighborhood Hits	27
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

C43BP_MOUSE
NC score	0.096610 (rank : 84)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	135	Target Neighborhood Hits	91	Shared Neighborhood Hits	54
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

FGD6_HUMAN
NC score	0.095955 (rank : 85)	θ value	0.125558 (rank : 78)
Query Neighborhood Hits	135	Target Neighborhood Hits	237	Shared Neighborhood Hits	55
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

RASA3_HUMAN
NC score	0.095166 (rank : 86)	θ value	0.62314 (rank : 90)
Query Neighborhood Hits	135	Target Neighborhood Hits	166	Shared Neighborhood Hits	41
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

OSBL3_HUMAN
NC score	0.095139 (rank : 87)	θ value	3.0926 (rank : 115)
Query Neighborhood Hits	135	Target Neighborhood Hits	93	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

MYO10_HUMAN
NC score	0.094228 (rank : 88)	θ value	0.00298849 (rank : 55)
Query Neighborhood Hits	135	Target Neighborhood Hits	920	Shared Neighborhood Hits	81
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

FGD6_MOUSE
NC score	0.094194 (rank : 89)	θ value	0.0431538 (rank : 66)
Query Neighborhood Hits	135	Target Neighborhood Hits	282	Shared Neighborhood Hits	55
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

OSBP2_MOUSE
NC score	0.093902 (rank : 90)	θ value	0.47712 (rank : 88)
Query Neighborhood Hits	135	Target Neighborhood Hits	150	Shared Neighborhood Hits	49
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

TARA_MOUSE
NC score	0.093400 (rank : 91)	θ value	0.0961366 (rank : 77)
Query Neighborhood Hits	135	Target Neighborhood Hits	1133	Shared Neighborhood Hits	64
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

MRIP_MOUSE
NC score	0.092951 (rank : 92)	θ value	1.38821 (rank : 99)
Query Neighborhood Hits	135	Target Neighborhood Hits	569	Shared Neighborhood Hits	65
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

FARP1_HUMAN
NC score	0.092154 (rank : 93)	θ value	2.36792 (rank : 106)
Query Neighborhood Hits	135	Target Neighborhood Hits	241	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

DGKH_HUMAN
NC score	0.091585 (rank : 94)	θ value	4.03905 (rank : 117)
Query Neighborhood Hits	135	Target Neighborhood Hits	255	Shared Neighborhood Hits	63
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

C43BP_HUMAN
NC score	0.090353 (rank : 95)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	135	Target Neighborhood Hits	87	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

OSBL3_MOUSE
NC score	0.089856 (rank : 96)	θ value	4.03905 (rank : 120)
Query Neighborhood Hits	135	Target Neighborhood Hits	86	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

FARP2_MOUSE
NC score	0.088438 (rank : 97)	θ value	0.365318 (rank : 85)
Query Neighborhood Hits	135	Target Neighborhood Hits	209	Shared Neighborhood Hits	52
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

RASA3_MOUSE
NC score	0.085107 (rank : 98)	θ value	4.03905 (rank : 121)
Query Neighborhood Hits	135	Target Neighborhood Hits	144	Shared Neighborhood Hits	38
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

AB1IP_HUMAN
NC score	0.081233 (rank : 99)	θ value	2.36792 (rank : 103)
Query Neighborhood Hits	135	Target Neighborhood Hits	213	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

FGD5_MOUSE
NC score	0.079798 (rank : 100)	θ value	3.0926 (rank : 113)
Query Neighborhood Hits	135	Target Neighborhood Hits	170	Shared Neighborhood Hits	39
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FARP2_HUMAN
NC score	0.079396 (rank : 101)	θ value	0.62314 (rank : 89)
Query Neighborhood Hits	135	Target Neighborhood Hits	240	Shared Neighborhood Hits	44
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

MRIP_HUMAN
NC score	0.079173 (rank : 102)	θ value	6.88961 (rank : 130)
Query Neighborhood Hits	135	Target Neighborhood Hits	578	Shared Neighborhood Hits	63
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

FGD4_HUMAN
NC score	0.078814 (rank : 103)	θ value	0.47712 (rank : 87)
Query Neighborhood Hits	135	Target Neighborhood Hits	219	Shared Neighborhood Hits	41
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

CEND1_HUMAN
NC score	0.078699 (rank : 104)	θ value	5.27518 (rank : 125)
Query Neighborhood Hits	135	Target Neighborhood Hits	284	Shared Neighborhood Hits	69
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

FGD4_MOUSE
NC score	0.077417 (rank : 105)	θ value	1.38821 (rank : 98)
Query Neighborhood Hits	135	Target Neighborhood Hits	227	Shared Neighborhood Hits	41
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

GAB1_HUMAN
NC score	0.076002 (rank : 106)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	135	Target Neighborhood Hits	279	Shared Neighborhood Hits	42
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB2_HUMAN
NC score	0.075995 (rank : 107)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	135	Target Neighborhood Hits	188	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GAB2_MOUSE
NC score	0.074360 (rank : 108)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	135	Target Neighborhood Hits	220	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

CEND2_HUMAN
NC score	0.073101 (rank : 109)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	135	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

FGD5_HUMAN
NC score	0.072461 (rank : 110)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	135	Target Neighborhood Hits	235	Shared Neighborhood Hits	46
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

GAB1_MOUSE
NC score	0.069618 (rank : 111)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	135	Target Neighborhood Hits	233	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CEND3_HUMAN
NC score	0.069088 (rank : 112)	θ value	2.36792 (rank : 105)
Query Neighborhood Hits	135	Target Neighborhood Hits	275	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

GRB7_HUMAN
NC score	0.068689 (rank : 113)	θ value	0.813845 (rank : 91)
Query Neighborhood Hits	135	Target Neighborhood Hits	156	Shared Neighborhood Hits	21
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

TARA_HUMAN
NC score	0.068418 (rank : 114)	θ value	0.163984 (rank : 81)
Query Neighborhood Hits	135	Target Neighborhood Hits	1626	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

AB1IP_MOUSE
NC score	0.063961 (rank : 115)	θ value	2.36792 (rank : 104)
Query Neighborhood Hits	135	Target Neighborhood Hits	181	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

CEND3_MOUSE
NC score	0.062210 (rank : 116)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	135	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

FGD2_HUMAN
NC score	0.060532 (rank : 117)	θ value	2.36792 (rank : 107)
Query Neighborhood Hits	135	Target Neighborhood Hits	151	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

OSBL7_HUMAN
NC score	0.060321 (rank : 118)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	135	Target Neighborhood Hits	71	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

CAPS2_HUMAN
NC score	0.059812 (rank : 119)	θ value	1.38821 (rank : 95)
Query Neighborhood Hits	135	Target Neighborhood Hits	81	Shared Neighborhood Hits	27
SwissProt Accessions	Q86UW7, Q658Q2, Q7Z5T7, Q8IZW9, Q8N7M4, Q9H6P4, Q9HCI1, Q9NWK8	Gene names	CADPS2, CAPS2, KIAA1591
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

FGD2_MOUSE
NC score	0.057928 (rank : 120)	θ value	1.38821 (rank : 97)
Query Neighborhood Hits	135	Target Neighborhood Hits	163	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

CENA2_MOUSE
NC score	0.057866 (rank : 121)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	135	Target Neighborhood Hits	68	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

PKHF2_MOUSE
NC score	0.055470 (rank : 122)	θ value	1.06291 (rank : 93)
Query Neighborhood Hits	135	Target Neighborhood Hits	77	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

FGD3_MOUSE
NC score	0.053406 (rank : 123)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	135	Target Neighborhood Hits	257	Shared Neighborhood Hits	30
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

CAPS2_MOUSE
NC score	0.052837 (rank : 124)	θ value	1.38821 (rank : 96)
Query Neighborhood Hits	135	Target Neighborhood Hits	78	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BYR5, O08903, Q66JM7, Q6PCL7, Q76I88, Q7TMM6, Q80ZV8, Q8BL25, Q8BY04, Q8K3K6	Gene names	Cadps2, Caps2
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

CEND1_MOUSE
NC score	0.051944 (rank : 125)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	135	Target Neighborhood Hits	260	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

OSBL2_HUMAN
NC score	0.051669 (rank : 126)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	135	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H1P3, Q9BZB1, Q9Y4B8	Gene names	OSBPL2, KIAA0772, ORP2
Domain Architecture
Description	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2).

FGD1_MOUSE
NC score	0.050684 (rank : 127)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	135	Target Neighborhood Hits	387	Shared Neighborhood Hits	32
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
NC score	0.050007 (rank : 128)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	135	Target Neighborhood Hits	367	Shared Neighborhood Hits	34
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

GRB10_MOUSE
NC score	0.047511 (rank : 129)	θ value	5.27518 (rank : 126)
Query Neighborhood Hits	135	Target Neighborhood Hits	156	Shared Neighborhood Hits	17
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

PKHF2_HUMAN
NC score	0.047114 (rank : 130)	θ value	1.81305 (rank : 101)
Query Neighborhood Hits	135	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

CAPS1_MOUSE
NC score	0.038869 (rank : 131)	θ value	5.27518 (rank : 124)
Query Neighborhood Hits	135	Target Neighborhood Hits	93	Shared Neighborhood Hits	20
SwissProt Accessions	Q80TJ1, Q3TSP2, Q61374, Q6AXB4, Q6PGF0	Gene names	Cadps, Caps, Caps1, Kiaa1121
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1).

CAPS1_HUMAN
NC score	0.038685 (rank : 132)	θ value	5.27518 (rank : 123)
Query Neighborhood Hits	135	Target Neighborhood Hits	86	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ULU8, Q13339, Q6GQQ6, Q8N2Z5, Q8N3M7, Q8NFR0, Q96BC2	Gene names	CADPS, CAPS, CAPS1, KIAA1121
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1).

AKT2_HUMAN
NC score	0.038190 (rank : 133)	θ value	0.0563607 (rank : 68)
Query Neighborhood Hits	135	Target Neighborhood Hits	878	Shared Neighborhood Hits	45
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
NC score	0.038044 (rank : 134)	θ value	0.0563607 (rank : 69)
Query Neighborhood Hits	135	Target Neighborhood Hits	875	Shared Neighborhood Hits	42
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

GRB14_MOUSE
NC score	0.034989 (rank : 135)	θ value	5.27518 (rank : 127)
Query Neighborhood Hits	135	Target Neighborhood Hits	149	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

AKT1_HUMAN
NC score	0.034922 (rank : 136)	θ value	0.0563607 (rank : 67)
Query Neighborhood Hits	135	Target Neighborhood Hits	885	Shared Neighborhood Hits	50
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
NC score	0.034307 (rank : 137)	θ value	0.0736092 (rank : 70)
Query Neighborhood Hits	135	Target Neighborhood Hits	878	Shared Neighborhood Hits	49
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT3_HUMAN
NC score	0.030290 (rank : 138)	θ value	0.279714 (rank : 82)
Query Neighborhood Hits	135	Target Neighborhood Hits	872	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.030285 (rank : 139)	θ value	0.279714 (rank : 83)
Query Neighborhood Hits	135	Target Neighborhood Hits	872	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

TEC_HUMAN
NC score	0.023427 (rank : 140)	θ value	1.81305 (rank : 102)
Query Neighborhood Hits	135	Target Neighborhood Hits	1006	Shared Neighborhood Hits	30
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

VASP_HUMAN
NC score	0.013673 (rank : 141)	θ value	4.03905 (rank : 122)
Query Neighborhood Hits	135	Target Neighborhood Hits	201	Shared Neighborhood Hits	6
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

SMC3_MOUSE
NC score	0.009815 (rank : 142)	θ value	6.88961 (rank : 132)
Query Neighborhood Hits	135	Target Neighborhood Hits	1187	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

SMC3_HUMAN
NC score	0.009719 (rank : 143)	θ value	6.88961 (rank : 131)
Query Neighborhood Hits	135	Target Neighborhood Hits	1186	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

MYST4_HUMAN
NC score	0.009037 (rank : 144)	θ value	4.03905 (rank : 119)
Query Neighborhood Hits	135	Target Neighborhood Hits	671	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

DZIP1_MOUSE
NC score	0.009032 (rank : 145)	θ value	4.03905 (rank : 118)
Query Neighborhood Hits	135	Target Neighborhood Hits	530	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BMD2, Q6ZQ10, Q9CRK5	Gene names	Dzip1, Kiaa0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1 homolog).

VASP_MOUSE
NC score	0.006400 (rank : 146)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	135	Target Neighborhood Hits	195	Shared Neighborhood Hits	3
SwissProt Accessions	P70460, Q3TAP0, Q3TCD2, Q3U0C2, Q3UDF1, Q91VD2, Q9R214	Gene names	Vasp
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

MY18A_MOUSE
NC score	0.006298 (rank : 147)	θ value	3.0926 (rank : 114)
Query Neighborhood Hits	135	Target Neighborhood Hits	1989	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYST4_MOUSE
NC score	0.006102 (rank : 148)	θ value	5.27518 (rank : 128)
Query Neighborhood Hits	135	Target Neighborhood Hits	416	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

LAMB1_HUMAN
NC score	0.002846 (rank : 149)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	135	Target Neighborhood Hits	1018	Shared Neighborhood Hits	14
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LAMB1_MOUSE
NC score	0.002538 (rank : 150)	θ value	6.88961 (rank : 129)
Query Neighborhood Hits	135	Target Neighborhood Hits	919	Shared Neighborhood Hits	12
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).