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Network neighborhood for query Sequence : MTMRD_HUMAN

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MTMRD_HUMAN
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MTMR5_HUMAN
θ value	0 (rank : 1)	NC score	0.984271 (rank : 2)
Query Neighborhood Hits	135	Target Neighborhood Hits	141	Shared Neighborhood Hits	86
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

MTMRD_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	135	Target Neighborhood Hits	135	Shared Neighborhood Hits	135
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

MTMR2_MOUSE
θ value	7.77379e-44 (rank : 3)	NC score	0.707665 (rank : 4)
Query Neighborhood Hits	135	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z2D1, Q8VHA7	Gene names	Mtmr2
Domain Architecture
Description	Myotubularin-related protein 2 (EC 3.1.3.-).

MTMR2_HUMAN
θ value	1.73182e-43 (rank : 4)	NC score	0.707375 (rank : 5)
Query Neighborhood Hits	135	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q13614, Q9UPS9	Gene names	MTMR2, KIAA1073
Domain Architecture
Description	Myotubularin-related protein 2 (EC 3.1.3.-).

MTMR3_HUMAN
θ value	1.12253e-42 (rank : 5)	NC score	0.638989 (rank : 15)
Query Neighborhood Hits	135	Target Neighborhood Hits	163	Shared Neighborhood Hits	21
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

MTMR3_MOUSE
θ value	1.3722e-40 (rank : 6)	NC score	0.709761 (rank : 3)
Query Neighborhood Hits	135	Target Neighborhood Hits	78	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K296	Gene names	Mtmr3
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48).

MTM1_HUMAN
θ value	8.61488e-35 (rank : 7)	NC score	0.700966 (rank : 6)
Query Neighborhood Hits	135	Target Neighborhood Hits	32	Shared Neighborhood Hits	15
SwissProt Accessions	Q13496, Q8NEL1	Gene names	MTM1, CG2
Domain Architecture
Description	Myotubularin (EC 3.1.3.48).

MTM1_MOUSE
θ value	1.46948e-34 (rank : 8)	NC score	0.700854 (rank : 7)
Query Neighborhood Hits	135	Target Neighborhood Hits	36	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z2C5	Gene names	Mtm1
Domain Architecture
Description	Myotubularin (EC 3.1.3.48).

MTMR1_HUMAN
θ value	5.584e-34 (rank : 9)	NC score	0.698409 (rank : 8)
Query Neighborhood Hits	135	Target Neighborhood Hits	28	Shared Neighborhood Hits	15
SwissProt Accessions	Q13613, Q9UBX6, Q9UEM0, Q9UQD5	Gene names	MTMR1
Domain Architecture
Description	Myotubularin-related protein 1 (EC 3.1.3.-).

MTMR1_MOUSE
θ value	2.34606e-32 (rank : 10)	NC score	0.696918 (rank : 9)
Query Neighborhood Hits	135	Target Neighborhood Hits	23	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z2C4	Gene names	Mtmr1
Domain Architecture
Description	Myotubularin-related protein 1 (EC 3.1.3.-).

MYCPP_HUMAN
θ value	3.06405e-32 (rank : 11)	NC score	0.526336 (rank : 16)
Query Neighborhood Hits	135	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z401, Q14655, Q86T77, Q8IVX2, Q8NB93	Gene names	MYCPBP, IRLB
Domain Architecture	No domain graphic available
Description	C-myc promoter-binding protein.

MTMR7_MOUSE
θ value	2.59387e-31 (rank : 12)	NC score	0.693596 (rank : 11)
Query Neighborhood Hits	135	Target Neighborhood Hits	81	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z2C9, Q8C4J6	Gene names	Mtmr7
Domain Architecture
Description	Myotubularin-related protein 7 (EC 3.1.3.-).

MTMR7_HUMAN
θ value	7.54701e-31 (rank : 13)	NC score	0.692878 (rank : 13)
Query Neighborhood Hits	135	Target Neighborhood Hits	71	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y216, Q68DX4	Gene names	MTMR7
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 7 (EC 3.1.3.-).

MTMR9_MOUSE
θ value	2.68423e-28 (rank : 14)	NC score	0.695261 (rank : 10)
Query Neighborhood Hits	135	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z2D0, Q80XL4	Gene names	Mtmr9, Mtmr3
Domain Architecture
Description	Myotubularin-related protein 9.

MTMR9_HUMAN
θ value	2.27234e-27 (rank : 15)	NC score	0.693141 (rank : 12)
Query Neighborhood Hits	135	Target Neighborhood Hits	16	Shared Neighborhood Hits	15
SwissProt Accessions	Q96QG7, Q52LU3, Q8WW11, Q96QG6, Q9NX50	Gene names	MTMR9, C8orf9, MTMR8
Domain Architecture
Description	Myotubularin-related protein 9.

MTMR6_HUMAN
θ value	2.51237e-26 (rank : 16)	NC score	0.690199 (rank : 14)
Query Neighborhood Hits	135	Target Neighborhood Hits	39	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y217, Q86TB7, Q86YH4, Q96P80	Gene names	MTMR6
Domain Architecture
Description	Myotubularin-related protein 6 (EC 3.1.3.-).

RA6I1_MOUSE
θ value	2.20094e-22 (rank : 17)	NC score	0.481402 (rank : 18)
Query Neighborhood Hits	135	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	Q6PAL8, Q62146, Q8C829, Q8VDF6, Q9QYZ2	Gene names	Rab6ip1
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

DEN4C_HUMAN
θ value	1.09232e-21 (rank : 18)	NC score	0.493668 (rank : 17)
Query Neighborhood Hits	135	Target Neighborhood Hits	63	Shared Neighborhood Hits	19
SwissProt Accessions	Q5VZ89, Q6AI48, Q6ZUB3, Q8NCY7, Q9H6N4, Q9NUT1, Q9NWA5	Gene names	DENND4C, C9orf55
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 4C.

RA6I1_HUMAN
θ value	1.86321e-21 (rank : 19)	NC score	0.479199 (rank : 19)
Query Neighborhood Hits	135	Target Neighborhood Hits	63	Shared Neighborhood Hits	16
SwissProt Accessions	Q6IQ26, Q96GN3, Q9H6U7, Q9UFV0, Q9UPR1	Gene names	RAB6IP1, KIAA1091
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

DEN2A_MOUSE
θ value	1.52774e-15 (rank : 20)	NC score	0.431908 (rank : 25)
Query Neighborhood Hits	135	Target Neighborhood Hits	53	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C4S8, Q3TJU2, Q3TUG3, Q3UXA3	Gene names	Dennd2a
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2A.

DEN2C_HUMAN
θ value	1.52774e-15 (rank : 21)	NC score	0.431996 (rank : 24)
Query Neighborhood Hits	135	Target Neighborhood Hits	58	Shared Neighborhood Hits	16
SwissProt Accessions	Q68D51, Q5TCX6, Q6P3R3	Gene names	DENND2C
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

DEN2A_HUMAN
θ value	4.91457e-14 (rank : 22)	NC score	0.421866 (rank : 27)
Query Neighborhood Hits	135	Target Neighborhood Hits	83	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ULE3, Q1RMD5, Q86XY0	Gene names	DENND2A, KIAA1277
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2A.

DEN1A_MOUSE
θ value	1.09485e-13 (rank : 23)	NC score	0.438591 (rank : 22)
Query Neighborhood Hits	135	Target Neighborhood Hits	178	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K382	Gene names	Dennd1a
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

DEN1A_HUMAN
θ value	3.18553e-13 (rank : 24)	NC score	0.435619 (rank : 23)
Query Neighborhood Hits	135	Target Neighborhood Hits	176	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TEH3, Q5VWF0, Q8IVD6, Q9H796	Gene names	DENND1A
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

DEN2C_MOUSE
θ value	1.58096e-12 (rank : 25)	NC score	0.424298 (rank : 26)
Query Neighborhood Hits	135	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	Q6P9P8, Q3T9X2, Q3UV30, Q80V46	Gene names	Dennd2c
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

DEN2D_MOUSE
θ value	1.58096e-12 (rank : 26)	NC score	0.444447 (rank : 21)
Query Neighborhood Hits	135	Target Neighborhood Hits	18	Shared Neighborhood Hits	16
SwissProt Accessions	Q91VV4, Q3U028, Q9D831	Gene names	Dennd2d
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2D.

ST5_MOUSE
θ value	3.52202e-12 (rank : 27)	NC score	0.416332 (rank : 28)
Query Neighborhood Hits	135	Target Neighborhood Hits	126	Shared Neighborhood Hits	16
SwissProt Accessions	Q924W7, Q78H54, Q8K2P3, Q924W8	Gene names	St5, Dennd2b
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (DENN domain-containing protein 2B).

DEN2D_HUMAN
θ value	1.02475e-11 (rank : 28)	NC score	0.444454 (rank : 20)
Query Neighborhood Hits	135	Target Neighborhood Hits	19	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H6A0, Q5T5V6, Q9BSU0	Gene names	DENND2D
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2D.

ST5_HUMAN
θ value	2.98157e-11 (rank : 29)	NC score	0.411494 (rank : 29)
Query Neighborhood Hits	135	Target Neighborhood Hits	151	Shared Neighborhood Hits	16
SwissProt Accessions	P78524, P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6	Gene names	ST5, DENND2B, HTS1
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (HeLa tumor suppression 1) (DENN domain-containing protein 2B).

PHLB2_HUMAN
θ value	1.06045e-08 (rank : 30)	NC score	0.156923 (rank : 39)
Query Neighborhood Hits	135	Target Neighborhood Hits	964	Shared Neighborhood Hits	52
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_MOUSE
θ value	5.26297e-08 (rank : 31)	NC score	0.150431 (rank : 40)
Query Neighborhood Hits	135	Target Neighborhood Hits	1016	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB1_MOUSE
θ value	8.97725e-08 (rank : 32)	NC score	0.187033 (rank : 34)
Query Neighborhood Hits	135	Target Neighborhood Hits	678	Shared Neighborhood Hits	49
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PHLB1_HUMAN
θ value	2.21117e-06 (rank : 33)	NC score	0.160765 (rank : 38)
Query Neighborhood Hits	135	Target Neighborhood Hits	1038	Shared Neighborhood Hits	47
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

C43BP_MOUSE
θ value	1.09739e-05 (rank : 34)	NC score	0.213599 (rank : 30)
Query Neighborhood Hits	135	Target Neighborhood Hits	91	Shared Neighborhood Hits	50
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_HUMAN
θ value	1.87187e-05 (rank : 35)	NC score	0.209178 (rank : 32)
Query Neighborhood Hits	135	Target Neighborhood Hits	87	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

PKHA3_HUMAN
θ value	5.44631e-05 (rank : 36)	NC score	0.211070 (rank : 31)
Query Neighborhood Hits	135	Target Neighborhood Hits	66	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_MOUSE
θ value	9.29e-05 (rank : 37)	NC score	0.208065 (rank : 33)
Query Neighborhood Hits	135	Target Neighborhood Hits	67	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

TBCD2_HUMAN
θ value	0.000121331 (rank : 38)	NC score	0.106778 (rank : 65)
Query Neighborhood Hits	135	Target Neighborhood Hits	419	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

OSBL9_HUMAN
θ value	0.000270298 (rank : 39)	NC score	0.161335 (rank : 37)
Query Neighborhood Hits	135	Target Neighborhood Hits	138	Shared Neighborhood Hits	55
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

FGD6_MOUSE
θ value	0.000602161 (rank : 40)	NC score	0.092019 (rank : 73)
Query Neighborhood Hits	135	Target Neighborhood Hits	282	Shared Neighborhood Hits	38
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
θ value	0.00134147 (rank : 41)	NC score	0.089113 (rank : 74)
Query Neighborhood Hits	135	Target Neighborhood Hits	237	Shared Neighborhood Hits	43
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

SWP70_HUMAN
θ value	0.00298849 (rank : 42)	NC score	0.097704 (rank : 69)
Query Neighborhood Hits	135	Target Neighborhood Hits	973	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	0.00298849 (rank : 43)	NC score	0.095213 (rank : 70)
Query Neighborhood Hits	135	Target Neighborhood Hits	1097	Shared Neighborhood Hits	69
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

MYO10_HUMAN
θ value	0.00390308 (rank : 44)	NC score	0.055480 (rank : 92)
Query Neighborhood Hits	135	Target Neighborhood Hits	920	Shared Neighborhood Hits	65
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

CYH3_MOUSE
θ value	0.00665767 (rank : 45)	NC score	0.131669 (rank : 47)
Query Neighborhood Hits	135	Target Neighborhood Hits	148	Shared Neighborhood Hits	63
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

PLEK_MOUSE
θ value	0.00869519 (rank : 46)	NC score	0.165987 (rank : 36)
Query Neighborhood Hits	135	Target Neighborhood Hits	109	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

DAPP1_MOUSE
θ value	0.0113563 (rank : 47)	NC score	0.137891 (rank : 44)
Query Neighborhood Hits	135	Target Neighborhood Hits	225	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_HUMAN
θ value	0.0148317 (rank : 48)	NC score	0.134014 (rank : 46)
Query Neighborhood Hits	135	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

OSB11_MOUSE
θ value	0.0148317 (rank : 49)	NC score	0.122145 (rank : 50)
Query Neighborhood Hits	135	Target Neighborhood Hits	71	Shared Neighborhood Hits	32
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSBP2_HUMAN
θ value	0.0148317 (rank : 50)	NC score	0.110029 (rank : 59)
Query Neighborhood Hits	135	Target Neighborhood Hits	154	Shared Neighborhood Hits	48
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

PKHA5_HUMAN
θ value	0.0148317 (rank : 51)	NC score	0.105371 (rank : 66)
Query Neighborhood Hits	135	Target Neighborhood Hits	455	Shared Neighborhood Hits	57
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

CEND2_HUMAN
θ value	0.0193708 (rank : 52)	NC score	0.070333 (rank : 81)
Query Neighborhood Hits	135	Target Neighborhood Hits	166	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CYH4_HUMAN
θ value	0.0252991 (rank : 53)	NC score	0.127041 (rank : 49)
Query Neighborhood Hits	135	Target Neighborhood Hits	135	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
θ value	0.0252991 (rank : 54)	NC score	0.127681 (rank : 48)
Query Neighborhood Hits	135	Target Neighborhood Hits	134	Shared Neighborhood Hits	60
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

PLEK_HUMAN
θ value	0.0252991 (rank : 55)	NC score	0.167209 (rank : 35)
Query Neighborhood Hits	135	Target Neighborhood Hits	110	Shared Neighborhood Hits	58
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

RASA1_HUMAN
θ value	0.0252991 (rank : 56)	NC score	0.072178 (rank : 80)
Query Neighborhood Hits	135	Target Neighborhood Hits	258	Shared Neighborhood Hits	44
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

DDEF2_MOUSE
θ value	0.0563607 (rank : 57)	NC score	0.049961 (rank : 101)
Query Neighborhood Hits	135	Target Neighborhood Hits	625	Shared Neighborhood Hits	32
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

GAB2_HUMAN
θ value	0.0563607 (rank : 58)	NC score	0.108575 (rank : 62)
Query Neighborhood Hits	135	Target Neighborhood Hits	188	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

TPH2_HUMAN
θ value	0.0736092 (rank : 59)	NC score	0.031180 (rank : 109)
Query Neighborhood Hits	135	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWU9	Gene names	TPH2, NTPH
Domain Architecture
Description	Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 2) (Neuronal tryptophan hydroxylase).

FARP1_HUMAN
θ value	0.0961366 (rank : 60)	NC score	0.044151 (rank : 106)
Query Neighborhood Hits	135	Target Neighborhood Hits	241	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

OSB10_HUMAN
θ value	0.0961366 (rank : 61)	NC score	0.106842 (rank : 64)
Query Neighborhood Hits	135	Target Neighborhood Hits	55	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

OSB11_HUMAN
θ value	0.0961366 (rank : 62)	NC score	0.114688 (rank : 53)
Query Neighborhood Hits	135	Target Neighborhood Hits	60	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

CEND3_HUMAN
θ value	0.125558 (rank : 63)	NC score	0.050429 (rank : 100)
Query Neighborhood Hits	135	Target Neighborhood Hits	275	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

OSBL3_HUMAN
θ value	0.125558 (rank : 64)	NC score	0.078981 (rank : 77)
Query Neighborhood Hits	135	Target Neighborhood Hits	93	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

PKHA4_MOUSE
θ value	0.125558 (rank : 65)	NC score	0.101337 (rank : 68)
Query Neighborhood Hits	135	Target Neighborhood Hits	202	Shared Neighborhood Hits	44
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CYH2_HUMAN
θ value	0.163984 (rank : 66)	NC score	0.112800 (rank : 56)
Query Neighborhood Hits	135	Target Neighborhood Hits	175	Shared Neighborhood Hits	60
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.163984 (rank : 67)	NC score	0.112835 (rank : 55)
Query Neighborhood Hits	135	Target Neighborhood Hits	171	Shared Neighborhood Hits	61
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH3_HUMAN
θ value	0.163984 (rank : 68)	NC score	0.114735 (rank : 52)
Query Neighborhood Hits	135	Target Neighborhood Hits	137	Shared Neighborhood Hits	57
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

GAB2_MOUSE
θ value	0.163984 (rank : 69)	NC score	0.107207 (rank : 63)
Query Neighborhood Hits	135	Target Neighborhood Hits	220	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

CENA2_HUMAN
θ value	0.279714 (rank : 70)	NC score	0.082259 (rank : 75)
Query Neighborhood Hits	135	Target Neighborhood Hits	83	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

PKHA4_HUMAN
θ value	0.279714 (rank : 71)	NC score	0.093570 (rank : 71)
Query Neighborhood Hits	135	Target Neighborhood Hits	283	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

DDEF2_HUMAN
θ value	0.365318 (rank : 72)	NC score	0.046219 (rank : 103)
Query Neighborhood Hits	135	Target Neighborhood Hits	599	Shared Neighborhood Hits	33
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

OSBL3_MOUSE
θ value	0.365318 (rank : 73)	NC score	0.075937 (rank : 79)
Query Neighborhood Hits	135	Target Neighborhood Hits	86	Shared Neighborhood Hits	39
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBP1_HUMAN
θ value	0.365318 (rank : 74)	NC score	0.119347 (rank : 51)
Query Neighborhood Hits	135	Target Neighborhood Hits	180	Shared Neighborhood Hits	61
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

MYH10_HUMAN
θ value	0.47712 (rank : 75)	NC score	0.014936 (rank : 117)
Query Neighborhood Hits	135	Target Neighborhood Hits	1620	Shared Neighborhood Hits	24
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
θ value	0.62314 (rank : 76)	NC score	0.015157 (rank : 116)
Query Neighborhood Hits	135	Target Neighborhood Hits	1612	Shared Neighborhood Hits	25
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

PKHA1_HUMAN
θ value	0.62314 (rank : 77)	NC score	0.146549 (rank : 42)
Query Neighborhood Hits	135	Target Neighborhood Hits	127	Shared Neighborhood Hits	62
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	0.62314 (rank : 78)	NC score	0.147415 (rank : 41)
Query Neighborhood Hits	135	Target Neighborhood Hits	120	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA6_MOUSE
θ value	0.62314 (rank : 79)	NC score	0.111714 (rank : 58)
Query Neighborhood Hits	135	Target Neighborhood Hits	591	Shared Neighborhood Hits	67
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PLEK2_MOUSE
θ value	0.62314 (rank : 80)	NC score	0.138665 (rank : 43)
Query Neighborhood Hits	135	Target Neighborhood Hits	96	Shared Neighborhood Hits	55
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

SPB6_MOUSE
θ value	0.62314 (rank : 81)	NC score	0.006196 (rank : 140)
Query Neighborhood Hits	135	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	Q60854	Gene names	Serpinb6, Serpinb6a, Spi3
Domain Architecture
Description	Serpin B6 (Placental thrombin inhibitor) (Protease inhibitor 6) (PI- 6).

CEND3_MOUSE
θ value	0.813845 (rank : 82)	NC score	0.044362 (rank : 105)
Query Neighborhood Hits	135	Target Neighborhood Hits	228	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

DDFL1_MOUSE
θ value	0.813845 (rank : 83)	NC score	0.045945 (rank : 104)
Query Neighborhood Hits	135	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

OSBP2_MOUSE
θ value	0.813845 (rank : 84)	NC score	0.092451 (rank : 72)
Query Neighborhood Hits	135	Target Neighborhood Hits	150	Shared Neighborhood Hits	46
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

PLEK2_HUMAN
θ value	0.813845 (rank : 85)	NC score	0.137527 (rank : 45)
Query Neighborhood Hits	135	Target Neighborhood Hits	101	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

RHG25_HUMAN
θ value	0.813845 (rank : 86)	NC score	0.078607 (rank : 78)
Query Neighborhood Hits	135	Target Neighborhood Hits	550	Shared Neighborhood Hits	71
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

TPH2_MOUSE
θ value	0.813845 (rank : 87)	NC score	0.025718 (rank : 111)
Query Neighborhood Hits	135	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CGV2	Gene names	Tph2, Ntph
Domain Architecture
Description	Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 2) (Neuronal tryptophan hydroxylase).

AKT3_HUMAN
θ value	1.06291 (rank : 88)	NC score	0.007924 (rank : 136)
Query Neighborhood Hits	135	Target Neighborhood Hits	872	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	1.06291 (rank : 89)	NC score	0.007921 (rank : 137)
Query Neighborhood Hits	135	Target Neighborhood Hits	872	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

CYH1_HUMAN
θ value	1.06291 (rank : 90)	NC score	0.112463 (rank : 57)
Query Neighborhood Hits	135	Target Neighborhood Hits	184	Shared Neighborhood Hits	61
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

PKHA6_HUMAN
θ value	1.06291 (rank : 91)	NC score	0.113405 (rank : 54)
Query Neighborhood Hits	135	Target Neighborhood Hits	556	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PTCD1_HUMAN
θ value	1.06291 (rank : 92)	NC score	0.027124 (rank : 110)
Query Neighborhood Hits	135	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	O75127, Q66K60, Q9UDV2	Gene names	PTCD1, KIAA0632
Domain Architecture	No domain graphic available
Description	Pentatricopeptide repeat protein 1.

AKT1_HUMAN
θ value	1.38821 (rank : 93)	NC score	0.010395 (rank : 127)
Query Neighborhood Hits	135	Target Neighborhood Hits	885	Shared Neighborhood Hits	42
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
θ value	1.38821 (rank : 94)	NC score	0.010168 (rank : 128)
Query Neighborhood Hits	135	Target Neighborhood Hits	878	Shared Neighborhood Hits	42
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT2_HUMAN
θ value	1.38821 (rank : 95)	NC score	0.009890 (rank : 130)
Query Neighborhood Hits	135	Target Neighborhood Hits	878	Shared Neighborhood Hits	36
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
θ value	1.38821 (rank : 96)	NC score	0.010011 (rank : 129)
Query Neighborhood Hits	135	Target Neighborhood Hits	875	Shared Neighborhood Hits	36
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

FGD5_MOUSE
θ value	1.38821 (rank : 97)	NC score	0.055902 (rank : 91)
Query Neighborhood Hits	135	Target Neighborhood Hits	170	Shared Neighborhood Hits	26
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

OSBL6_HUMAN
θ value	1.38821 (rank : 98)	NC score	0.067250 (rank : 85)
Query Neighborhood Hits	135	Target Neighborhood Hits	101	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

CKAP4_HUMAN
θ value	1.81305 (rank : 99)	NC score	0.014631 (rank : 118)
Query Neighborhood Hits	135	Target Neighborhood Hits	592	Shared Neighborhood Hits	12
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

CYH1_MOUSE
θ value	1.81305 (rank : 100)	NC score	0.109227 (rank : 60)
Query Neighborhood Hits	135	Target Neighborhood Hits	176	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

DGKH_HUMAN
θ value	1.81305 (rank : 101)	NC score	0.031351 (rank : 108)
Query Neighborhood Hits	135	Target Neighborhood Hits	255	Shared Neighborhood Hits	40
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

K0513_HUMAN
θ value	1.81305 (rank : 102)	NC score	0.051426 (rank : 98)
Query Neighborhood Hits	135	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	O60268, Q8N6G0	Gene names	KIAA0513
Domain Architecture	No domain graphic available
Description	Protein KIAA0513.

OSBL6_MOUSE
θ value	1.81305 (rank : 103)	NC score	0.065716 (rank : 86)
Query Neighborhood Hits	135	Target Neighborhood Hits	105	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BXR9, Q8BYW2	Gene names	Osbpl6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

SFRIP_HUMAN
θ value	1.81305 (rank : 104)	NC score	0.014461 (rank : 119)
Query Neighborhood Hits	135	Target Neighborhood Hits	530	Shared Neighborhood Hits	4
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

RHG25_MOUSE
θ value	2.36792 (rank : 105)	NC score	0.068162 (rank : 84)
Query Neighborhood Hits	135	Target Neighborhood Hits	492	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

ATX1_HUMAN
θ value	3.0926 (rank : 106)	NC score	0.016267 (rank : 115)
Query Neighborhood Hits	135	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	P54253, Q9UJG2, Q9Y4J1	Gene names	ATXN1, ATX1, SCA1
Domain Architecture
Description	Ataxin-1 (Spinocerebellar ataxia type 1 protein).

CENA2_MOUSE
θ value	3.0926 (rank : 107)	NC score	0.064145 (rank : 87)
Query Neighborhood Hits	135	Target Neighborhood Hits	68	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

DDFL1_HUMAN
θ value	3.0926 (rank : 108)	NC score	0.047698 (rank : 102)
Query Neighborhood Hits	135	Target Neighborhood Hits	353	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

K0513_MOUSE
θ value	3.0926 (rank : 109)	NC score	0.054524 (rank : 93)
Query Neighborhood Hits	135	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R0A7, Q80TY8, Q8BQV3, Q8C8N9, Q8CCN0	Gene names	Kiaa0513
Domain Architecture	No domain graphic available
Description	Protein KIAA0513.

DZIP3_HUMAN
θ value	4.03905 (rank : 110)	NC score	0.008075 (rank : 134)
Query Neighborhood Hits	135	Target Neighborhood Hits	399	Shared Neighborhood Hits	4
SwissProt Accessions	Q86Y13, O75162, Q6P3R9, Q6PH82, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9	Gene names	DZIP3, KIAA0675
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138).

GDAP1_MOUSE
θ value	4.03905 (rank : 111)	NC score	0.011938 (rank : 123)
Query Neighborhood Hits	135	Target Neighborhood Hits	64	Shared Neighborhood Hits	2
SwissProt Accessions	O88741, Q8C7Q5, Q9CTN2	Gene names	Gdap1
Domain Architecture
Description	Ganglioside-induced differentiation-associated protein 1 (GDAP1).

PKHA2_HUMAN
θ value	4.03905 (rank : 112)	NC score	0.109056 (rank : 61)
Query Neighborhood Hits	135	Target Neighborhood Hits	119	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PLCG1_MOUSE
θ value	4.03905 (rank : 113)	NC score	0.013928 (rank : 120)
Query Neighborhood Hits	135	Target Neighborhood Hits	314	Shared Neighborhood Hits	13
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SOX6_HUMAN
θ value	4.03905 (rank : 114)	NC score	0.011817 (rank : 125)
Query Neighborhood Hits	135	Target Neighborhood Hits	332	Shared Neighborhood Hits	5
SwissProt Accessions	P35712, Q9BXQ3, Q9BXQ4, Q9BXQ5, Q9H0I8	Gene names	SOX6
Domain Architecture
Description	Transcription factor SOX-6.

SOX6_MOUSE
θ value	4.03905 (rank : 115)	NC score	0.011754 (rank : 126)
Query Neighborhood Hits	135	Target Neighborhood Hits	341	Shared Neighborhood Hits	5
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

SYNE1_HUMAN
θ value	4.03905 (rank : 116)	NC score	0.009804 (rank : 131)
Query Neighborhood Hits	135	Target Neighborhood Hits	1484	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

TEX9_MOUSE
θ value	4.03905 (rank : 117)	NC score	0.017477 (rank : 114)
Query Neighborhood Hits	135	Target Neighborhood Hits	581	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

TF2H2_MOUSE
θ value	4.03905 (rank : 118)	NC score	0.021372 (rank : 112)
Query Neighborhood Hits	135	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIB4	Gene names	Gtf2h2, Btf2p44
Domain Architecture
Description	TFIIH basal transcription factor complex p44 subunit (Basic transcription factor 2 44 kDa subunit) (BTF2-p44) (General transcription factor IIH polypeptide 2).

KI13B_HUMAN
θ value	5.27518 (rank : 119)	NC score	0.007716 (rank : 138)
Query Neighborhood Hits	135	Target Neighborhood Hits	492	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NQT8, O75134, Q9BYJ6	Gene names	KIF13B, GAKIN, KIAA0639
Domain Architecture
Description	Kinesin-like protein KIF13B (Kinesin-like protein GAKIN).

MEGF8_MOUSE
θ value	5.27518 (rank : 120)	NC score	0.002403 (rank : 143)
Query Neighborhood Hits	135	Target Neighborhood Hits	520	Shared Neighborhood Hits	4
SwissProt Accessions	P60882, Q80TR3, Q80V41, Q8BMN9, Q8JZW7, Q8K0J3	Gene names	Megf8, Egfl4
Domain Architecture
Description	Multiple epidermal growth factor-like domains 8 (EGF-like domain- containing protein 4) (Multiple EGF-like domain protein 4).

P4HA2_HUMAN
θ value	5.27518 (rank : 121)	NC score	0.012739 (rank : 121)
Query Neighborhood Hits	135	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	O15460, Q8WWN0	Gene names	P4HA2
Domain Architecture
Description	Prolyl 4-hydroxylase alpha-2 subunit precursor (EC 1.14.11.2) (4-PH alpha-2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-2 subunit).

PGBM_HUMAN
θ value	5.27518 (rank : 122)	NC score	-0.001620 (rank : 145)
Query Neighborhood Hits	135	Target Neighborhood Hits	1113	Shared Neighborhood Hits	5
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

RNF31_MOUSE
θ value	5.27518 (rank : 123)	NC score	0.009224 (rank : 133)
Query Neighborhood Hits	135	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q924T7	Gene names	Rnf31
Domain Architecture
Description	RING finger protein 31.

TF2H2_HUMAN
θ value	5.27518 (rank : 124)	NC score	0.020059 (rank : 113)
Query Neighborhood Hits	135	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q13888, Q15570, Q15571, Q9BS41	Gene names	GTF2H2, BTF2P44
Domain Architecture
Description	TFIIH basal transcription factor complex p44 subunit (Basic transcription factor 2 44 kDa subunit) (BTF2-p44) (General transcription factor IIH polypeptide 2).

CAN3_MOUSE
θ value	6.88961 (rank : 125)	NC score	0.002918 (rank : 142)
Query Neighborhood Hits	135	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	Q64691, Q9WUC5	Gene names	Capn3
Domain Architecture
Description	Calpain-3 (EC 3.4.22.-) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3).

FAM45_MOUSE
θ value	6.88961 (rank : 126)	NC score	0.009616 (rank : 132)
Query Neighborhood Hits	135	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D8N2, Q91WS5	Gene names	Fam45
Domain Architecture	No domain graphic available
Description	Protein FAM45.

FGD5_HUMAN
θ value	6.88961 (rank : 127)	NC score	0.051241 (rank : 99)
Query Neighborhood Hits	135	Target Neighborhood Hits	235	Shared Neighborhood Hits	30
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

P4HA2_MOUSE
θ value	6.88961 (rank : 128)	NC score	0.011885 (rank : 124)
Query Neighborhood Hits	135	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q60716, Q8VBU4	Gene names	P4ha2
Domain Architecture
Description	Prolyl 4-hydroxylase alpha-2 subunit precursor (EC 1.14.11.2) (4-PH alpha-2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-2 subunit).

PKP4_MOUSE
θ value	6.88961 (rank : 129)	NC score	0.005514 (rank : 141)
Query Neighborhood Hits	135	Target Neighborhood Hits	129	Shared Neighborhood Hits	3
SwissProt Accessions	Q68FH0, Q640N0, Q68G56, Q8BK47, Q8BVH1, Q9CRE3	Gene names	Pkp4, Armrp
Domain Architecture	No domain graphic available
Description	Plakophilin-4 (Armadillo-related protein).

SYNPO_HUMAN
θ value	6.88961 (rank : 130)	NC score	0.008032 (rank : 135)
Query Neighborhood Hits	135	Target Neighborhood Hits	281	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

CIR_HUMAN
θ value	8.99809 (rank : 131)	NC score	0.007300 (rank : 139)
Query Neighborhood Hits	135	Target Neighborhood Hits	249	Shared Neighborhood Hits	4
SwissProt Accessions	Q86X95, O95367, Q12804, Q4G1B9, Q6PJI4, Q8IWI2	Gene names	CIR
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor (Recepin).

CLK4_MOUSE
θ value	8.99809 (rank : 132)	NC score	-0.001164 (rank : 144)
Query Neighborhood Hits	135	Target Neighborhood Hits	759	Shared Neighborhood Hits	8
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

FARP2_HUMAN
θ value	8.99809 (rank : 133)	NC score	0.034117 (rank : 107)
Query Neighborhood Hits	135	Target Neighborhood Hits	240	Shared Neighborhood Hits	32
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PLCG1_HUMAN
θ value	8.99809 (rank : 134)	NC score	0.012286 (rank : 122)
Query Neighborhood Hits	135	Target Neighborhood Hits	293	Shared Neighborhood Hits	12
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ZN586_HUMAN
θ value	8.99809 (rank : 135)	NC score	-0.003588 (rank : 146)
Query Neighborhood Hits	135	Target Neighborhood Hits	637	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NXT0	Gene names	ZNF586
Domain Architecture	No domain graphic available
Description	Zinc finger protein 586.

CEND1_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.054286 (rank : 94)
Query Neighborhood Hits	135	Target Neighborhood Hits	284	Shared Neighborhood Hits	52
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CNKR1_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.080530 (rank : 76)
Query Neighborhood Hits	135	Target Neighborhood Hits	154	Shared Neighborhood Hits	38
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.056423 (rank : 90)
Query Neighborhood Hits	135	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.056514 (rank : 89)
Query Neighborhood Hits	135	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

GAB1_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.070263 (rank : 82)
Query Neighborhood Hits	135	Target Neighborhood Hits	279	Shared Neighborhood Hits	38
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB1_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.068585 (rank : 83)
Query Neighborhood Hits	135	Target Neighborhood Hits	233	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

OSBL5_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.052139 (rank : 96)
Query Neighborhood Hits	135	Target Neighborhood Hits	117	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

OSBL5_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.052138 (rank : 97)
Query Neighborhood Hits	135	Target Neighborhood Hits	77	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ER64, Q8R510, Q99NF5	Gene names	Osbpl5, Obph1, Osbp2
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5) (Oxysterol-binding protein homolog 1).

OSBL7_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.061437 (rank : 88)
Query Neighborhood Hits	135	Target Neighborhood Hits	71	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

OSBL8_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.054119 (rank : 95)
Query Neighborhood Hits	135	Target Neighborhood Hits	289	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

PKHA2_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.104793 (rank : 67)
Query Neighborhood Hits	135	Target Neighborhood Hits	116	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

Hits sorted by NC score

MTMRD_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	135	Target Neighborhood Hits	135	Shared Neighborhood Hits	135
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

MTMR5_HUMAN
NC score	0.984271 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	135	Target Neighborhood Hits	141	Shared Neighborhood Hits	86
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

MTMR3_MOUSE
NC score	0.709761 (rank : 3)	θ value	1.3722e-40 (rank : 6)
Query Neighborhood Hits	135	Target Neighborhood Hits	78	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K296	Gene names	Mtmr3
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48).

MTMR2_MOUSE
NC score	0.707665 (rank : 4)	θ value	7.77379e-44 (rank : 3)
Query Neighborhood Hits	135	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z2D1, Q8VHA7	Gene names	Mtmr2
Domain Architecture
Description	Myotubularin-related protein 2 (EC 3.1.3.-).

MTMR2_HUMAN
NC score	0.707375 (rank : 5)	θ value	1.73182e-43 (rank : 4)
Query Neighborhood Hits	135	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q13614, Q9UPS9	Gene names	MTMR2, KIAA1073
Domain Architecture
Description	Myotubularin-related protein 2 (EC 3.1.3.-).

MTM1_HUMAN
NC score	0.700966 (rank : 6)	θ value	8.61488e-35 (rank : 7)
Query Neighborhood Hits	135	Target Neighborhood Hits	32	Shared Neighborhood Hits	15
SwissProt Accessions	Q13496, Q8NEL1	Gene names	MTM1, CG2
Domain Architecture
Description	Myotubularin (EC 3.1.3.48).

MTM1_MOUSE
NC score	0.700854 (rank : 7)	θ value	1.46948e-34 (rank : 8)
Query Neighborhood Hits	135	Target Neighborhood Hits	36	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z2C5	Gene names	Mtm1
Domain Architecture
Description	Myotubularin (EC 3.1.3.48).

MTMR1_HUMAN
NC score	0.698409 (rank : 8)	θ value	5.584e-34 (rank : 9)
Query Neighborhood Hits	135	Target Neighborhood Hits	28	Shared Neighborhood Hits	15
SwissProt Accessions	Q13613, Q9UBX6, Q9UEM0, Q9UQD5	Gene names	MTMR1
Domain Architecture
Description	Myotubularin-related protein 1 (EC 3.1.3.-).

MTMR1_MOUSE
NC score	0.696918 (rank : 9)	θ value	2.34606e-32 (rank : 10)
Query Neighborhood Hits	135	Target Neighborhood Hits	23	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z2C4	Gene names	Mtmr1
Domain Architecture
Description	Myotubularin-related protein 1 (EC 3.1.3.-).

MTMR9_MOUSE
NC score	0.695261 (rank : 10)	θ value	2.68423e-28 (rank : 14)
Query Neighborhood Hits	135	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z2D0, Q80XL4	Gene names	Mtmr9, Mtmr3
Domain Architecture
Description	Myotubularin-related protein 9.

MTMR7_MOUSE
NC score	0.693596 (rank : 11)	θ value	2.59387e-31 (rank : 12)
Query Neighborhood Hits	135	Target Neighborhood Hits	81	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z2C9, Q8C4J6	Gene names	Mtmr7
Domain Architecture
Description	Myotubularin-related protein 7 (EC 3.1.3.-).

MTMR9_HUMAN
NC score	0.693141 (rank : 12)	θ value	2.27234e-27 (rank : 15)
Query Neighborhood Hits	135	Target Neighborhood Hits	16	Shared Neighborhood Hits	15
SwissProt Accessions	Q96QG7, Q52LU3, Q8WW11, Q96QG6, Q9NX50	Gene names	MTMR9, C8orf9, MTMR8
Domain Architecture
Description	Myotubularin-related protein 9.

MTMR7_HUMAN
NC score	0.692878 (rank : 13)	θ value	7.54701e-31 (rank : 13)
Query Neighborhood Hits	135	Target Neighborhood Hits	71	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y216, Q68DX4	Gene names	MTMR7
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 7 (EC 3.1.3.-).

MTMR6_HUMAN
NC score	0.690199 (rank : 14)	θ value	2.51237e-26 (rank : 16)
Query Neighborhood Hits	135	Target Neighborhood Hits	39	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y217, Q86TB7, Q86YH4, Q96P80	Gene names	MTMR6
Domain Architecture
Description	Myotubularin-related protein 6 (EC 3.1.3.-).

MTMR3_HUMAN
NC score	0.638989 (rank : 15)	θ value	1.12253e-42 (rank : 5)
Query Neighborhood Hits	135	Target Neighborhood Hits	163	Shared Neighborhood Hits	21
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

MYCPP_HUMAN
NC score	0.526336 (rank : 16)	θ value	3.06405e-32 (rank : 11)
Query Neighborhood Hits	135	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z401, Q14655, Q86T77, Q8IVX2, Q8NB93	Gene names	MYCPBP, IRLB
Domain Architecture	No domain graphic available
Description	C-myc promoter-binding protein.

DEN4C_HUMAN
NC score	0.493668 (rank : 17)	θ value	1.09232e-21 (rank : 18)
Query Neighborhood Hits	135	Target Neighborhood Hits	63	Shared Neighborhood Hits	19
SwissProt Accessions	Q5VZ89, Q6AI48, Q6ZUB3, Q8NCY7, Q9H6N4, Q9NUT1, Q9NWA5	Gene names	DENND4C, C9orf55
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 4C.

RA6I1_MOUSE
NC score	0.481402 (rank : 18)	θ value	2.20094e-22 (rank : 17)
Query Neighborhood Hits	135	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	Q6PAL8, Q62146, Q8C829, Q8VDF6, Q9QYZ2	Gene names	Rab6ip1
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

RA6I1_HUMAN
NC score	0.479199 (rank : 19)	θ value	1.86321e-21 (rank : 19)
Query Neighborhood Hits	135	Target Neighborhood Hits	63	Shared Neighborhood Hits	16
SwissProt Accessions	Q6IQ26, Q96GN3, Q9H6U7, Q9UFV0, Q9UPR1	Gene names	RAB6IP1, KIAA1091
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

DEN2D_HUMAN
NC score	0.444454 (rank : 20)	θ value	1.02475e-11 (rank : 28)
Query Neighborhood Hits	135	Target Neighborhood Hits	19	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H6A0, Q5T5V6, Q9BSU0	Gene names	DENND2D
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2D.

DEN2D_MOUSE
NC score	0.444447 (rank : 21)	θ value	1.58096e-12 (rank : 26)
Query Neighborhood Hits	135	Target Neighborhood Hits	18	Shared Neighborhood Hits	16
SwissProt Accessions	Q91VV4, Q3U028, Q9D831	Gene names	Dennd2d
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2D.

DEN1A_MOUSE
NC score	0.438591 (rank : 22)	θ value	1.09485e-13 (rank : 23)
Query Neighborhood Hits	135	Target Neighborhood Hits	178	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K382	Gene names	Dennd1a
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

DEN1A_HUMAN
NC score	0.435619 (rank : 23)	θ value	3.18553e-13 (rank : 24)
Query Neighborhood Hits	135	Target Neighborhood Hits	176	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TEH3, Q5VWF0, Q8IVD6, Q9H796	Gene names	DENND1A
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

DEN2C_HUMAN
NC score	0.431996 (rank : 24)	θ value	1.52774e-15 (rank : 21)
Query Neighborhood Hits	135	Target Neighborhood Hits	58	Shared Neighborhood Hits	16
SwissProt Accessions	Q68D51, Q5TCX6, Q6P3R3	Gene names	DENND2C
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

DEN2A_MOUSE
NC score	0.431908 (rank : 25)	θ value	1.52774e-15 (rank : 20)
Query Neighborhood Hits	135	Target Neighborhood Hits	53	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C4S8, Q3TJU2, Q3TUG3, Q3UXA3	Gene names	Dennd2a
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2A.

DEN2C_MOUSE
NC score	0.424298 (rank : 26)	θ value	1.58096e-12 (rank : 25)
Query Neighborhood Hits	135	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	Q6P9P8, Q3T9X2, Q3UV30, Q80V46	Gene names	Dennd2c
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

DEN2A_HUMAN
NC score	0.421866 (rank : 27)	θ value	4.91457e-14 (rank : 22)
Query Neighborhood Hits	135	Target Neighborhood Hits	83	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ULE3, Q1RMD5, Q86XY0	Gene names	DENND2A, KIAA1277
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2A.

ST5_MOUSE
NC score	0.416332 (rank : 28)	θ value	3.52202e-12 (rank : 27)
Query Neighborhood Hits	135	Target Neighborhood Hits	126	Shared Neighborhood Hits	16
SwissProt Accessions	Q924W7, Q78H54, Q8K2P3, Q924W8	Gene names	St5, Dennd2b
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (DENN domain-containing protein 2B).

ST5_HUMAN
NC score	0.411494 (rank : 29)	θ value	2.98157e-11 (rank : 29)
Query Neighborhood Hits	135	Target Neighborhood Hits	151	Shared Neighborhood Hits	16
SwissProt Accessions	P78524, P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6	Gene names	ST5, DENND2B, HTS1
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (HeLa tumor suppression 1) (DENN domain-containing protein 2B).

C43BP_MOUSE
NC score	0.213599 (rank : 30)	θ value	1.09739e-05 (rank : 34)
Query Neighborhood Hits	135	Target Neighborhood Hits	91	Shared Neighborhood Hits	50
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

PKHA3_HUMAN
NC score	0.211070 (rank : 31)	θ value	5.44631e-05 (rank : 36)
Query Neighborhood Hits	135	Target Neighborhood Hits	66	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

C43BP_HUMAN
NC score	0.209178 (rank : 32)	θ value	1.87187e-05 (rank : 35)
Query Neighborhood Hits	135	Target Neighborhood Hits	87	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

PKHA3_MOUSE
NC score	0.208065 (rank : 33)	θ value	9.29e-05 (rank : 37)
Query Neighborhood Hits	135	Target Neighborhood Hits	67	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PHLB1_MOUSE
NC score	0.187033 (rank : 34)	θ value	8.97725e-08 (rank : 32)
Query Neighborhood Hits	135	Target Neighborhood Hits	678	Shared Neighborhood Hits	49
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PLEK_HUMAN
NC score	0.167209 (rank : 35)	θ value	0.0252991 (rank : 55)
Query Neighborhood Hits	135	Target Neighborhood Hits	110	Shared Neighborhood Hits	58
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
NC score	0.165987 (rank : 36)	θ value	0.00869519 (rank : 46)
Query Neighborhood Hits	135	Target Neighborhood Hits	109	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

OSBL9_HUMAN
NC score	0.161335 (rank : 37)	θ value	0.000270298 (rank : 39)
Query Neighborhood Hits	135	Target Neighborhood Hits	138	Shared Neighborhood Hits	55
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PHLB1_HUMAN
NC score	0.160765 (rank : 38)	θ value	2.21117e-06 (rank : 33)
Query Neighborhood Hits	135	Target Neighborhood Hits	1038	Shared Neighborhood Hits	47
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PHLB2_HUMAN
NC score	0.156923 (rank : 39)	θ value	1.06045e-08 (rank : 30)
Query Neighborhood Hits	135	Target Neighborhood Hits	964	Shared Neighborhood Hits	52
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_MOUSE
NC score	0.150431 (rank : 40)	θ value	5.26297e-08 (rank : 31)
Query Neighborhood Hits	135	Target Neighborhood Hits	1016	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PKHA1_MOUSE
NC score	0.147415 (rank : 41)	θ value	0.62314 (rank : 78)
Query Neighborhood Hits	135	Target Neighborhood Hits	120	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_HUMAN
NC score	0.146549 (rank : 42)	θ value	0.62314 (rank : 77)
Query Neighborhood Hits	135	Target Neighborhood Hits	127	Shared Neighborhood Hits	62
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PLEK2_MOUSE
NC score	0.138665 (rank : 43)	θ value	0.62314 (rank : 80)
Query Neighborhood Hits	135	Target Neighborhood Hits	96	Shared Neighborhood Hits	55
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

DAPP1_MOUSE
NC score	0.137891 (rank : 44)	θ value	0.0113563 (rank : 47)
Query Neighborhood Hits	135	Target Neighborhood Hits	225	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PLEK2_HUMAN
NC score	0.137527 (rank : 45)	θ value	0.813845 (rank : 85)
Query Neighborhood Hits	135	Target Neighborhood Hits	101	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

DAPP1_HUMAN
NC score	0.134014 (rank : 46)	θ value	0.0148317 (rank : 48)
Query Neighborhood Hits	135	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CYH3_MOUSE
NC score	0.131669 (rank : 47)	θ value	0.00665767 (rank : 45)
Query Neighborhood Hits	135	Target Neighborhood Hits	148	Shared Neighborhood Hits	63
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH4_MOUSE
NC score	0.127681 (rank : 48)	θ value	0.0252991 (rank : 54)
Query Neighborhood Hits	135	Target Neighborhood Hits	134	Shared Neighborhood Hits	60
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH4_HUMAN
NC score	0.127041 (rank : 49)	θ value	0.0252991 (rank : 53)
Query Neighborhood Hits	135	Target Neighborhood Hits	135	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

OSB11_MOUSE
NC score	0.122145 (rank : 50)	θ value	0.0148317 (rank : 49)
Query Neighborhood Hits	135	Target Neighborhood Hits	71	Shared Neighborhood Hits	32
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSBP1_HUMAN
NC score	0.119347 (rank : 51)	θ value	0.365318 (rank : 74)
Query Neighborhood Hits	135	Target Neighborhood Hits	180	Shared Neighborhood Hits	61
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

CYH3_HUMAN
NC score	0.114735 (rank : 52)	θ value	0.163984 (rank : 68)
Query Neighborhood Hits	135	Target Neighborhood Hits	137	Shared Neighborhood Hits	57
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

OSB11_HUMAN
NC score	0.114688 (rank : 53)	θ value	0.0961366 (rank : 62)
Query Neighborhood Hits	135	Target Neighborhood Hits	60	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

PKHA6_HUMAN
NC score	0.113405 (rank : 54)	θ value	1.06291 (rank : 91)
Query Neighborhood Hits	135	Target Neighborhood Hits	556	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CYH2_MOUSE
NC score	0.112835 (rank : 55)	θ value	0.163984 (rank : 67)
Query Neighborhood Hits	135	Target Neighborhood Hits	171	Shared Neighborhood Hits	61
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.112800 (rank : 56)	θ value	0.163984 (rank : 66)
Query Neighborhood Hits	135	Target Neighborhood Hits	175	Shared Neighborhood Hits	60
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH1_HUMAN
NC score	0.112463 (rank : 57)	θ value	1.06291 (rank : 90)
Query Neighborhood Hits	135	Target Neighborhood Hits	184	Shared Neighborhood Hits	61
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

PKHA6_MOUSE
NC score	0.111714 (rank : 58)	θ value	0.62314 (rank : 79)
Query Neighborhood Hits	135	Target Neighborhood Hits	591	Shared Neighborhood Hits	67
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

OSBP2_HUMAN
NC score	0.110029 (rank : 59)	θ value	0.0148317 (rank : 50)
Query Neighborhood Hits	135	Target Neighborhood Hits	154	Shared Neighborhood Hits	48
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

CYH1_MOUSE
NC score	0.109227 (rank : 60)	θ value	1.81305 (rank : 100)
Query Neighborhood Hits	135	Target Neighborhood Hits	176	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

PKHA2_HUMAN
NC score	0.109056 (rank : 61)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	135	Target Neighborhood Hits	119	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

GAB2_HUMAN
NC score	0.108575 (rank : 62)	θ value	0.0563607 (rank : 58)
Query Neighborhood Hits	135	Target Neighborhood Hits	188	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GAB2_MOUSE
NC score	0.107207 (rank : 63)	θ value	0.163984 (rank : 69)
Query Neighborhood Hits	135	Target Neighborhood Hits	220	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

OSB10_HUMAN
NC score	0.106842 (rank : 64)	θ value	0.0961366 (rank : 61)
Query Neighborhood Hits	135	Target Neighborhood Hits	55	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

TBCD2_HUMAN
NC score	0.106778 (rank : 65)	θ value	0.000121331 (rank : 38)
Query Neighborhood Hits	135	Target Neighborhood Hits	419	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

PKHA5_HUMAN
NC score	0.105371 (rank : 66)	θ value	0.0148317 (rank : 51)
Query Neighborhood Hits	135	Target Neighborhood Hits	455	Shared Neighborhood Hits	57
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA2_MOUSE
NC score	0.104793 (rank : 67)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	135	Target Neighborhood Hits	116	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA4_MOUSE
NC score	0.101337 (rank : 68)	θ value	0.125558 (rank : 65)
Query Neighborhood Hits	135	Target Neighborhood Hits	202	Shared Neighborhood Hits	44
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

SWP70_HUMAN
NC score	0.097704 (rank : 69)	θ value	0.00298849 (rank : 42)
Query Neighborhood Hits	135	Target Neighborhood Hits	973	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
NC score	0.095213 (rank : 70)	θ value	0.00298849 (rank : 43)
Query Neighborhood Hits	135	Target Neighborhood Hits	1097	Shared Neighborhood Hits	69
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PKHA4_HUMAN
NC score	0.093570 (rank : 71)	θ value	0.279714 (rank : 71)
Query Neighborhood Hits	135	Target Neighborhood Hits	283	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

OSBP2_MOUSE
NC score	0.092451 (rank : 72)	θ value	0.813845 (rank : 84)
Query Neighborhood Hits	135	Target Neighborhood Hits	150	Shared Neighborhood Hits	46
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

FGD6_MOUSE
NC score	0.092019 (rank : 73)	θ value	0.000602161 (rank : 40)
Query Neighborhood Hits	135	Target Neighborhood Hits	282	Shared Neighborhood Hits	38
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.089113 (rank : 74)	θ value	0.00134147 (rank : 41)
Query Neighborhood Hits	135	Target Neighborhood Hits	237	Shared Neighborhood Hits	43
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

CENA2_HUMAN
NC score	0.082259 (rank : 75)	θ value	0.279714 (rank : 70)
Query Neighborhood Hits	135	Target Neighborhood Hits	83	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CNKR1_HUMAN
NC score	0.080530 (rank : 76)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	135	Target Neighborhood Hits	154	Shared Neighborhood Hits	38
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

OSBL3_HUMAN
NC score	0.078981 (rank : 77)	θ value	0.125558 (rank : 64)
Query Neighborhood Hits	135	Target Neighborhood Hits	93	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

RHG25_HUMAN
NC score	0.078607 (rank : 78)	θ value	0.813845 (rank : 86)
Query Neighborhood Hits	135	Target Neighborhood Hits	550	Shared Neighborhood Hits	71
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

OSBL3_MOUSE
NC score	0.075937 (rank : 79)	θ value	0.365318 (rank : 73)
Query Neighborhood Hits	135	Target Neighborhood Hits	86	Shared Neighborhood Hits	39
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

RASA1_HUMAN
NC score	0.072178 (rank : 80)	θ value	0.0252991 (rank : 56)
Query Neighborhood Hits	135	Target Neighborhood Hits	258	Shared Neighborhood Hits	44
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

CEND2_HUMAN
NC score	0.070333 (rank : 81)	θ value	0.0193708 (rank : 52)
Query Neighborhood Hits	135	Target Neighborhood Hits	166	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

GAB1_HUMAN
NC score	0.070263 (rank : 82)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	135	Target Neighborhood Hits	279	Shared Neighborhood Hits	38
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB1_MOUSE
NC score	0.068585 (rank : 83)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	135	Target Neighborhood Hits	233	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

RHG25_MOUSE
NC score	0.068162 (rank : 84)	θ value	2.36792 (rank : 105)
Query Neighborhood Hits	135	Target Neighborhood Hits	492	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

OSBL6_HUMAN
NC score	0.067250 (rank : 85)	θ value	1.38821 (rank : 98)
Query Neighborhood Hits	135	Target Neighborhood Hits	101	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL6_MOUSE
NC score	0.065716 (rank : 86)	θ value	1.81305 (rank : 103)
Query Neighborhood Hits	135	Target Neighborhood Hits	105	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BXR9, Q8BYW2	Gene names	Osbpl6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

CENA2_MOUSE
NC score	0.064145 (rank : 87)	θ value	3.0926 (rank : 107)
Query Neighborhood Hits	135	Target Neighborhood Hits	68	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

OSBL7_HUMAN
NC score	0.061437 (rank : 88)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	135	Target Neighborhood Hits	71	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

CNKR2_MOUSE
NC score	0.056514 (rank : 89)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	135	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.056423 (rank : 90)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	135	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

FGD5_MOUSE
NC score	0.055902 (rank : 91)	θ value	1.38821 (rank : 97)
Query Neighborhood Hits	135	Target Neighborhood Hits	170	Shared Neighborhood Hits	26
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

MYO10_HUMAN
NC score	0.055480 (rank : 92)	θ value	0.00390308 (rank : 44)
Query Neighborhood Hits	135	Target Neighborhood Hits	920	Shared Neighborhood Hits	65
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

K0513_MOUSE
NC score	0.054524 (rank : 93)	θ value	3.0926 (rank : 109)
Query Neighborhood Hits	135	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R0A7, Q80TY8, Q8BQV3, Q8C8N9, Q8CCN0	Gene names	Kiaa0513
Domain Architecture	No domain graphic available
Description	Protein KIAA0513.

CEND1_HUMAN
NC score	0.054286 (rank : 94)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	135	Target Neighborhood Hits	284	Shared Neighborhood Hits	52
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

OSBL8_HUMAN
NC score	0.054119 (rank : 95)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	135	Target Neighborhood Hits	289	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

OSBL5_HUMAN
NC score	0.052139 (rank : 96)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	135	Target Neighborhood Hits	117	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

OSBL5_MOUSE
NC score	0.052138 (rank : 97)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	135	Target Neighborhood Hits	77	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ER64, Q8R510, Q99NF5	Gene names	Osbpl5, Obph1, Osbp2
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5) (Oxysterol-binding protein homolog 1).

K0513_HUMAN
NC score	0.051426 (rank : 98)	θ value	1.81305 (rank : 102)
Query Neighborhood Hits	135	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	O60268, Q8N6G0	Gene names	KIAA0513
Domain Architecture	No domain graphic available
Description	Protein KIAA0513.

FGD5_HUMAN
NC score	0.051241 (rank : 99)	θ value	6.88961 (rank : 127)
Query Neighborhood Hits	135	Target Neighborhood Hits	235	Shared Neighborhood Hits	30
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

CEND3_HUMAN
NC score	0.050429 (rank : 100)	θ value	0.125558 (rank : 63)
Query Neighborhood Hits	135	Target Neighborhood Hits	275	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

DDEF2_MOUSE
NC score	0.049961 (rank : 101)	θ value	0.0563607 (rank : 57)
Query Neighborhood Hits	135	Target Neighborhood Hits	625	Shared Neighborhood Hits	32
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDFL1_HUMAN
NC score	0.047698 (rank : 102)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	135	Target Neighborhood Hits	353	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DDEF2_HUMAN
NC score	0.046219 (rank : 103)	θ value	0.365318 (rank : 72)
Query Neighborhood Hits	135	Target Neighborhood Hits	599	Shared Neighborhood Hits	33
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDFL1_MOUSE
NC score	0.045945 (rank : 104)	θ value	0.813845 (rank : 83)
Query Neighborhood Hits	135	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

CEND3_MOUSE
NC score	0.044362 (rank : 105)	θ value	0.813845 (rank : 82)
Query Neighborhood Hits	135	Target Neighborhood Hits	228	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

FARP1_HUMAN
NC score	0.044151 (rank : 106)	θ value	0.0961366 (rank : 60)
Query Neighborhood Hits	135	Target Neighborhood Hits	241	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
NC score	0.034117 (rank : 107)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	135	Target Neighborhood Hits	240	Shared Neighborhood Hits	32
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

DGKH_HUMAN
NC score	0.031351 (rank : 108)	θ value	1.81305 (rank : 101)
Query Neighborhood Hits	135	Target Neighborhood Hits	255	Shared Neighborhood Hits	40
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

TPH2_HUMAN
NC score	0.031180 (rank : 109)	θ value	0.0736092 (rank : 59)
Query Neighborhood Hits	135	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWU9	Gene names	TPH2, NTPH
Domain Architecture
Description	Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 2) (Neuronal tryptophan hydroxylase).

PTCD1_HUMAN
NC score	0.027124 (rank : 110)	θ value	1.06291 (rank : 92)
Query Neighborhood Hits	135	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	O75127, Q66K60, Q9UDV2	Gene names	PTCD1, KIAA0632
Domain Architecture	No domain graphic available
Description	Pentatricopeptide repeat protein 1.

TPH2_MOUSE
NC score	0.025718 (rank : 111)	θ value	0.813845 (rank : 87)
Query Neighborhood Hits	135	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CGV2	Gene names	Tph2, Ntph
Domain Architecture
Description	Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 2) (Neuronal tryptophan hydroxylase).

TF2H2_MOUSE
NC score	0.021372 (rank : 112)	θ value	4.03905 (rank : 118)
Query Neighborhood Hits	135	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIB4	Gene names	Gtf2h2, Btf2p44
Domain Architecture
Description	TFIIH basal transcription factor complex p44 subunit (Basic transcription factor 2 44 kDa subunit) (BTF2-p44) (General transcription factor IIH polypeptide 2).

TF2H2_HUMAN
NC score	0.020059 (rank : 113)	θ value	5.27518 (rank : 124)
Query Neighborhood Hits	135	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q13888, Q15570, Q15571, Q9BS41	Gene names	GTF2H2, BTF2P44
Domain Architecture
Description	TFIIH basal transcription factor complex p44 subunit (Basic transcription factor 2 44 kDa subunit) (BTF2-p44) (General transcription factor IIH polypeptide 2).

TEX9_MOUSE
NC score	0.017477 (rank : 114)	θ value	4.03905 (rank : 117)
Query Neighborhood Hits	135	Target Neighborhood Hits	581	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

ATX1_HUMAN
NC score	0.016267 (rank : 115)	θ value	3.0926 (rank : 106)
Query Neighborhood Hits	135	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	P54253, Q9UJG2, Q9Y4J1	Gene names	ATXN1, ATX1, SCA1
Domain Architecture
Description	Ataxin-1 (Spinocerebellar ataxia type 1 protein).

MYH10_MOUSE
NC score	0.015157 (rank : 116)	θ value	0.62314 (rank : 76)
Query Neighborhood Hits	135	Target Neighborhood Hits	1612	Shared Neighborhood Hits	25
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_HUMAN
NC score	0.014936 (rank : 117)	θ value	0.47712 (rank : 75)
Query Neighborhood Hits	135	Target Neighborhood Hits	1620	Shared Neighborhood Hits	24
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

CKAP4_HUMAN
NC score	0.014631 (rank : 118)	θ value	1.81305 (rank : 99)
Query Neighborhood Hits	135	Target Neighborhood Hits	592	Shared Neighborhood Hits	12
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

SFRIP_HUMAN
NC score	0.014461 (rank : 119)	θ value	1.81305 (rank : 104)
Query Neighborhood Hits	135	Target Neighborhood Hits	530	Shared Neighborhood Hits	4
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

PLCG1_MOUSE
NC score	0.013928 (rank : 120)	θ value	4.03905 (rank : 113)
Query Neighborhood Hits	135	Target Neighborhood Hits	314	Shared Neighborhood Hits	13
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

P4HA2_HUMAN
NC score	0.012739 (rank : 121)	θ value	5.27518 (rank : 121)
Query Neighborhood Hits	135	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	O15460, Q8WWN0	Gene names	P4HA2
Domain Architecture
Description	Prolyl 4-hydroxylase alpha-2 subunit precursor (EC 1.14.11.2) (4-PH alpha-2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-2 subunit).

PLCG1_HUMAN
NC score	0.012286 (rank : 122)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	135	Target Neighborhood Hits	293	Shared Neighborhood Hits	12
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

GDAP1_MOUSE
NC score	0.011938 (rank : 123)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	135	Target Neighborhood Hits	64	Shared Neighborhood Hits	2
SwissProt Accessions	O88741, Q8C7Q5, Q9CTN2	Gene names	Gdap1
Domain Architecture
Description	Ganglioside-induced differentiation-associated protein 1 (GDAP1).

P4HA2_MOUSE
NC score	0.011885 (rank : 124)	θ value	6.88961 (rank : 128)
Query Neighborhood Hits	135	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q60716, Q8VBU4	Gene names	P4ha2
Domain Architecture
Description	Prolyl 4-hydroxylase alpha-2 subunit precursor (EC 1.14.11.2) (4-PH alpha-2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-2 subunit).

SOX6_HUMAN
NC score	0.011817 (rank : 125)	θ value	4.03905 (rank : 114)
Query Neighborhood Hits	135	Target Neighborhood Hits	332	Shared Neighborhood Hits	5
SwissProt Accessions	P35712, Q9BXQ3, Q9BXQ4, Q9BXQ5, Q9H0I8	Gene names	SOX6
Domain Architecture
Description	Transcription factor SOX-6.

SOX6_MOUSE
NC score	0.011754 (rank : 126)	θ value	4.03905 (rank : 115)
Query Neighborhood Hits	135	Target Neighborhood Hits	341	Shared Neighborhood Hits	5
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

AKT1_HUMAN
NC score	0.010395 (rank : 127)	θ value	1.38821 (rank : 93)
Query Neighborhood Hits	135	Target Neighborhood Hits	885	Shared Neighborhood Hits	42
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
NC score	0.010168 (rank : 128)	θ value	1.38821 (rank : 94)
Query Neighborhood Hits	135	Target Neighborhood Hits	878	Shared Neighborhood Hits	42
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT2_MOUSE
NC score	0.010011 (rank : 129)	θ value	1.38821 (rank : 96)
Query Neighborhood Hits	135	Target Neighborhood Hits	875	Shared Neighborhood Hits	36
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_HUMAN
NC score	0.009890 (rank : 130)	θ value	1.38821 (rank : 95)
Query Neighborhood Hits	135	Target Neighborhood Hits	878	Shared Neighborhood Hits	36
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

SYNE1_HUMAN
NC score	0.009804 (rank : 131)	θ value	4.03905 (rank : 116)
Query Neighborhood Hits	135	Target Neighborhood Hits	1484	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

FAM45_MOUSE
NC score	0.009616 (rank : 132)	θ value	6.88961 (rank : 126)
Query Neighborhood Hits	135	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D8N2, Q91WS5	Gene names	Fam45
Domain Architecture	No domain graphic available
Description	Protein FAM45.

RNF31_MOUSE
NC score	0.009224 (rank : 133)	θ value	5.27518 (rank : 123)
Query Neighborhood Hits	135	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q924T7	Gene names	Rnf31
Domain Architecture
Description	RING finger protein 31.

DZIP3_HUMAN
NC score	0.008075 (rank : 134)	θ value	4.03905 (rank : 110)
Query Neighborhood Hits	135	Target Neighborhood Hits	399	Shared Neighborhood Hits	4
SwissProt Accessions	Q86Y13, O75162, Q6P3R9, Q6PH82, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9	Gene names	DZIP3, KIAA0675
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138).

SYNPO_HUMAN
NC score	0.008032 (rank : 135)	θ value	6.88961 (rank : 130)
Query Neighborhood Hits	135	Target Neighborhood Hits	281	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

AKT3_HUMAN
NC score	0.007924 (rank : 136)	θ value	1.06291 (rank : 88)
Query Neighborhood Hits	135	Target Neighborhood Hits	872	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.007921 (rank : 137)	θ value	1.06291 (rank : 89)
Query Neighborhood Hits	135	Target Neighborhood Hits	872	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

KI13B_HUMAN
NC score	0.007716 (rank : 138)	θ value	5.27518 (rank : 119)
Query Neighborhood Hits	135	Target Neighborhood Hits	492	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NQT8, O75134, Q9BYJ6	Gene names	KIF13B, GAKIN, KIAA0639
Domain Architecture
Description	Kinesin-like protein KIF13B (Kinesin-like protein GAKIN).

CIR_HUMAN
NC score	0.007300 (rank : 139)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	135	Target Neighborhood Hits	249	Shared Neighborhood Hits	4
SwissProt Accessions	Q86X95, O95367, Q12804, Q4G1B9, Q6PJI4, Q8IWI2	Gene names	CIR
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor (Recepin).

SPB6_MOUSE
NC score	0.006196 (rank : 140)	θ value	0.62314 (rank : 81)
Query Neighborhood Hits	135	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	Q60854	Gene names	Serpinb6, Serpinb6a, Spi3
Domain Architecture
Description	Serpin B6 (Placental thrombin inhibitor) (Protease inhibitor 6) (PI- 6).

PKP4_MOUSE
NC score	0.005514 (rank : 141)	θ value	6.88961 (rank : 129)
Query Neighborhood Hits	135	Target Neighborhood Hits	129	Shared Neighborhood Hits	3
SwissProt Accessions	Q68FH0, Q640N0, Q68G56, Q8BK47, Q8BVH1, Q9CRE3	Gene names	Pkp4, Armrp
Domain Architecture	No domain graphic available
Description	Plakophilin-4 (Armadillo-related protein).

CAN3_MOUSE
NC score	0.002918 (rank : 142)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	135	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	Q64691, Q9WUC5	Gene names	Capn3
Domain Architecture
Description	Calpain-3 (EC 3.4.22.-) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3).

MEGF8_MOUSE
NC score	0.002403 (rank : 143)	θ value	5.27518 (rank : 120)
Query Neighborhood Hits	135	Target Neighborhood Hits	520	Shared Neighborhood Hits	4
SwissProt Accessions	P60882, Q80TR3, Q80V41, Q8BMN9, Q8JZW7, Q8K0J3	Gene names	Megf8, Egfl4
Domain Architecture
Description	Multiple epidermal growth factor-like domains 8 (EGF-like domain- containing protein 4) (Multiple EGF-like domain protein 4).

CLK4_MOUSE
NC score	-0.001164 (rank : 144)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	135	Target Neighborhood Hits	759	Shared Neighborhood Hits	8
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

PGBM_HUMAN
NC score	-0.001620 (rank : 145)	θ value	5.27518 (rank : 122)
Query Neighborhood Hits	135	Target Neighborhood Hits	1113	Shared Neighborhood Hits	5
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

ZN586_HUMAN
NC score	-0.003588 (rank : 146)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	135	Target Neighborhood Hits	637	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NXT0	Gene names	ZNF586
Domain Architecture	No domain graphic available
Description	Zinc finger protein 586.