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Network neighborhood for query Sequence : CNKR1_HUMAN

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CNKR1_HUMAN
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CNKR1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	154	Target Neighborhood Hits	154	Shared Neighborhood Hits	154
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_HUMAN
θ value	5.95217e-44 (rank : 2)	NC score	0.751337 (rank : 3)
Query Neighborhood Hits	154	Target Neighborhood Hits	197	Shared Neighborhood Hits	64
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	5.95217e-44 (rank : 3)	NC score	0.751612 (rank : 2)
Query Neighborhood Hits	154	Target Neighborhood Hits	197	Shared Neighborhood Hits	64
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

PKHA4_MOUSE
θ value	2.28291e-11 (rank : 4)	NC score	0.532983 (rank : 4)
Query Neighborhood Hits	154	Target Neighborhood Hits	202	Shared Neighborhood Hits	61
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_HUMAN
θ value	3.29651e-10 (rank : 5)	NC score	0.510786 (rank : 5)
Query Neighborhood Hits	154	Target Neighborhood Hits	283	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CYH1_HUMAN
θ value	2.61198e-07 (rank : 6)	NC score	0.404290 (rank : 10)
Query Neighborhood Hits	154	Target Neighborhood Hits	184	Shared Neighborhood Hits	63
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	2.61198e-07 (rank : 7)	NC score	0.403559 (rank : 13)
Query Neighborhood Hits	154	Target Neighborhood Hits	176	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH3_HUMAN
θ value	2.61198e-07 (rank : 8)	NC score	0.407232 (rank : 8)
Query Neighborhood Hits	154	Target Neighborhood Hits	137	Shared Neighborhood Hits	60
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH2_HUMAN
θ value	9.92553e-07 (rank : 9)	NC score	0.404142 (rank : 11)
Query Neighborhood Hits	154	Target Neighborhood Hits	175	Shared Neighborhood Hits	61
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	9.92553e-07 (rank : 10)	NC score	0.403951 (rank : 12)
Query Neighborhood Hits	154	Target Neighborhood Hits	171	Shared Neighborhood Hits	62
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH3_MOUSE
θ value	1.69304e-06 (rank : 11)	NC score	0.399820 (rank : 15)
Query Neighborhood Hits	154	Target Neighborhood Hits	148	Shared Neighborhood Hits	60
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

PKHA5_HUMAN
θ value	1.69304e-06 (rank : 12)	NC score	0.419910 (rank : 7)
Query Neighborhood Hits	154	Target Neighborhood Hits	455	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

CYH4_MOUSE
θ value	3.77169e-06 (rank : 13)	NC score	0.398844 (rank : 16)
Query Neighborhood Hits	154	Target Neighborhood Hits	134	Shared Neighborhood Hits	59
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH4_HUMAN
θ value	4.92598e-06 (rank : 14)	NC score	0.401760 (rank : 14)
Query Neighborhood Hits	154	Target Neighborhood Hits	135	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

PKHA6_HUMAN
θ value	7.1131e-05 (rank : 15)	NC score	0.425015 (rank : 6)
Query Neighborhood Hits	154	Target Neighborhood Hits	556	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	0.000270298 (rank : 16)	NC score	0.406545 (rank : 9)
Query Neighborhood Hits	154	Target Neighborhood Hits	591	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PSD4_HUMAN
θ value	0.000270298 (rank : 17)	NC score	0.266161 (rank : 18)
Query Neighborhood Hits	154	Target Neighborhood Hits	178	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

GAB1_HUMAN
θ value	0.000602161 (rank : 18)	NC score	0.225505 (rank : 22)
Query Neighborhood Hits	154	Target Neighborhood Hits	279	Shared Neighborhood Hits	43
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

MRIP_MOUSE
θ value	0.00134147 (rank : 19)	NC score	0.213503 (rank : 27)
Query Neighborhood Hits	154	Target Neighborhood Hits	569	Shared Neighborhood Hits	57
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

RHG25_HUMAN
θ value	0.00228821 (rank : 20)	NC score	0.215600 (rank : 26)
Query Neighborhood Hits	154	Target Neighborhood Hits	550	Shared Neighborhood Hits	64
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

TARA_MOUSE
θ value	0.00228821 (rank : 21)	NC score	0.182995 (rank : 37)
Query Neighborhood Hits	154	Target Neighborhood Hits	1133	Shared Neighborhood Hits	74
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

GAB1_MOUSE
θ value	0.00298849 (rank : 22)	NC score	0.225241 (rank : 23)
Query Neighborhood Hits	154	Target Neighborhood Hits	233	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

OGFR_HUMAN
θ value	0.00390308 (rank : 23)	NC score	0.069820 (rank : 113)
Query Neighborhood Hits	154	Target Neighborhood Hits	1582	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

RHG25_MOUSE
θ value	0.00390308 (rank : 24)	NC score	0.210548 (rank : 28)
Query Neighborhood Hits	154	Target Neighborhood Hits	492	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

DYN3_HUMAN
θ value	0.0113563 (rank : 25)	NC score	0.173514 (rank : 41)
Query Neighborhood Hits	154	Target Neighborhood Hits	158	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

MAGI2_HUMAN
θ value	0.0148317 (rank : 26)	NC score	0.122428 (rank : 69)
Query Neighborhood Hits	154	Target Neighborhood Hits	373	Shared Neighborhood Hits	26
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

DGKD_HUMAN
θ value	0.0193708 (rank : 27)	NC score	0.125030 (rank : 68)
Query Neighborhood Hits	154	Target Neighborhood Hits	231	Shared Neighborhood Hits	29
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

FGD6_MOUSE
θ value	0.0193708 (rank : 28)	NC score	0.149435 (rank : 60)
Query Neighborhood Hits	154	Target Neighborhood Hits	282	Shared Neighborhood Hits	41
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

MAGI2_MOUSE
θ value	0.0193708 (rank : 29)	NC score	0.115708 (rank : 74)
Query Neighborhood Hits	154	Target Neighborhood Hits	370	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MRIP_HUMAN
θ value	0.0193708 (rank : 30)	NC score	0.200363 (rank : 30)
Query Neighborhood Hits	154	Target Neighborhood Hits	578	Shared Neighborhood Hits	56
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

TNR1A_HUMAN
θ value	0.0193708 (rank : 31)	NC score	0.062576 (rank : 119)
Query Neighborhood Hits	154	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	P19438	Gene names	TNFRSF1A, TNFAR, TNFR1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55) (CD120a antigen) [Contains: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)].

PLEK_HUMAN
θ value	0.0252991 (rank : 32)	NC score	0.273033 (rank : 17)
Query Neighborhood Hits	154	Target Neighborhood Hits	110	Shared Neighborhood Hits	52
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

DYN1_HUMAN
θ value	0.0330416 (rank : 33)	NC score	0.154191 (rank : 54)
Query Neighborhood Hits	154	Target Neighborhood Hits	216	Shared Neighborhood Hits	41
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_MOUSE
θ value	0.0330416 (rank : 34)	NC score	0.152735 (rank : 55)
Query Neighborhood Hits	154	Target Neighborhood Hits	168	Shared Neighborhood Hits	39
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

FARP2_MOUSE
θ value	0.0330416 (rank : 35)	NC score	0.120322 (rank : 71)
Query Neighborhood Hits	154	Target Neighborhood Hits	209	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD6_HUMAN
θ value	0.0330416 (rank : 36)	NC score	0.145195 (rank : 62)
Query Neighborhood Hits	154	Target Neighborhood Hits	237	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

MTMR5_HUMAN
θ value	0.0431538 (rank : 37)	NC score	0.107653 (rank : 79)
Query Neighborhood Hits	154	Target Neighborhood Hits	141	Shared Neighborhood Hits	31
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

ANLN_MOUSE
θ value	0.0563607 (rank : 38)	NC score	0.175339 (rank : 40)
Query Neighborhood Hits	154	Target Neighborhood Hits	297	Shared Neighborhood Hits	27
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

MYO10_HUMAN
θ value	0.0563607 (rank : 39)	NC score	0.098635 (rank : 87)
Query Neighborhood Hits	154	Target Neighborhood Hits	920	Shared Neighborhood Hits	65
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

NOS1_HUMAN
θ value	0.0563607 (rank : 40)	NC score	0.039328 (rank : 159)
Query Neighborhood Hits	154	Target Neighborhood Hits	218	Shared Neighborhood Hits	11
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

SHAN2_HUMAN
θ value	0.0563607 (rank : 41)	NC score	0.148277 (rank : 61)
Query Neighborhood Hits	154	Target Neighborhood Hits	346	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN2_MOUSE
θ value	0.0563607 (rank : 42)	NC score	0.140965 (rank : 65)
Query Neighborhood Hits	154	Target Neighborhood Hits	446	Shared Neighborhood Hits	32
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

TARA_HUMAN
θ value	0.0563607 (rank : 43)	NC score	0.140747 (rank : 66)
Query Neighborhood Hits	154	Target Neighborhood Hits	1626	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

GAB2_MOUSE
θ value	0.0736092 (rank : 44)	NC score	0.223519 (rank : 24)
Query Neighborhood Hits	154	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

ANLN_HUMAN
θ value	0.0961366 (rank : 45)	NC score	0.195356 (rank : 32)
Query Neighborhood Hits	154	Target Neighborhood Hits	222	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

DGKH_HUMAN
θ value	0.125558 (rank : 46)	NC score	0.158287 (rank : 50)
Query Neighborhood Hits	154	Target Neighborhood Hits	255	Shared Neighborhood Hits	52
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

GAB2_HUMAN
θ value	0.125558 (rank : 47)	NC score	0.217854 (rank : 25)
Query Neighborhood Hits	154	Target Neighborhood Hits	188	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

PLEK_MOUSE
θ value	0.125558 (rank : 48)	NC score	0.251608 (rank : 20)
Query Neighborhood Hits	154	Target Neighborhood Hits	109	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

FGD5_HUMAN
θ value	0.21417 (rank : 49)	NC score	0.152454 (rank : 56)
Query Neighborhood Hits	154	Target Neighborhood Hits	235	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

NRX2A_HUMAN
θ value	0.21417 (rank : 50)	NC score	0.038392 (rank : 161)
Query Neighborhood Hits	154	Target Neighborhood Hits	614	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	0.21417 (rank : 51)	NC score	0.054655 (rank : 132)
Query Neighborhood Hits	154	Target Neighborhood Hits	481	Shared Neighborhood Hits	20
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

PHLB1_HUMAN
θ value	0.21417 (rank : 52)	NC score	0.104956 (rank : 83)
Query Neighborhood Hits	154	Target Neighborhood Hits	1038	Shared Neighborhood Hits	58
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

RASA1_HUMAN
θ value	0.21417 (rank : 53)	NC score	0.104713 (rank : 84)
Query Neighborhood Hits	154	Target Neighborhood Hits	258	Shared Neighborhood Hits	31
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

TIAM1_HUMAN
θ value	0.21417 (rank : 54)	NC score	0.097472 (rank : 88)
Query Neighborhood Hits	154	Target Neighborhood Hits	225	Shared Neighborhood Hits	35
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	0.21417 (rank : 55)	NC score	0.092954 (rank : 90)
Query Neighborhood Hits	154	Target Neighborhood Hits	205	Shared Neighborhood Hits	32
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD5_MOUSE
θ value	0.279714 (rank : 56)	NC score	0.156301 (rank : 51)
Query Neighborhood Hits	154	Target Neighborhood Hits	170	Shared Neighborhood Hits	35
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

PRD14_HUMAN
θ value	0.279714 (rank : 57)	NC score	0.001831 (rank : 215)
Query Neighborhood Hits	154	Target Neighborhood Hits	757	Shared Neighborhood Hits	3
SwissProt Accessions	Q9GZV8, Q86UX9	Gene names	PRDM14
Domain Architecture
Description	PR domain zinc finger protein 14 (PR domain-containing protein 14).

BCL9_HUMAN
θ value	0.365318 (rank : 58)	NC score	0.047527 (rank : 146)
Query Neighborhood Hits	154	Target Neighborhood Hits	1008	Shared Neighborhood Hits	38
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

CEND3_HUMAN
θ value	0.365318 (rank : 59)	NC score	0.083945 (rank : 95)
Query Neighborhood Hits	154	Target Neighborhood Hits	275	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

LIMK2_HUMAN
θ value	0.365318 (rank : 60)	NC score	0.004558 (rank : 212)
Query Neighborhood Hits	154	Target Neighborhood Hits	986	Shared Neighborhood Hits	12
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

NFH_MOUSE
θ value	0.365318 (rank : 61)	NC score	0.035601 (rank : 164)
Query Neighborhood Hits	154	Target Neighborhood Hits	2247	Shared Neighborhood Hits	56
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

PSD4_MOUSE
θ value	0.365318 (rank : 62)	NC score	0.236210 (rank : 21)
Query Neighborhood Hits	154	Target Neighborhood Hits	78	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

RGS3_MOUSE
θ value	0.365318 (rank : 63)	NC score	0.041787 (rank : 154)
Query Neighborhood Hits	154	Target Neighborhood Hits	1621	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SWP70_MOUSE
θ value	0.365318 (rank : 64)	NC score	0.112602 (rank : 76)
Query Neighborhood Hits	154	Target Neighborhood Hits	1097	Shared Neighborhood Hits	55
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

FARP1_HUMAN
θ value	0.47712 (rank : 65)	NC score	0.121102 (rank : 70)
Query Neighborhood Hits	154	Target Neighborhood Hits	241	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

SAM14_HUMAN
θ value	0.47712 (rank : 66)	NC score	0.140738 (rank : 67)
Query Neighborhood Hits	154	Target Neighborhood Hits	81	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IZD0, Q8N2X0	Gene names	SAMD14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

SFR14_MOUSE
θ value	0.47712 (rank : 67)	NC score	0.041039 (rank : 157)
Query Neighborhood Hits	154	Target Neighborhood Hits	238	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CH09, Q6PG19, Q80UY8, Q8BY32, Q8CFM0	Gene names	Sfrs14
Domain Architecture	No domain graphic available
Description	Putative splicing factor, arginine/serine-rich 14 (Arginine/serine- rich-splicing factor 14).

SWP70_HUMAN
θ value	0.47712 (rank : 68)	NC score	0.118055 (rank : 73)
Query Neighborhood Hits	154	Target Neighborhood Hits	973	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

FA62A_MOUSE
θ value	0.62314 (rank : 69)	NC score	0.029070 (rank : 170)
Query Neighborhood Hits	154	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

GNRP_MOUSE
θ value	0.62314 (rank : 70)	NC score	0.111605 (rank : 78)
Query Neighborhood Hits	154	Target Neighborhood Hits	191	Shared Neighborhood Hits	36
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

TTF2_MOUSE
θ value	0.62314 (rank : 71)	NC score	0.026444 (rank : 176)
Query Neighborhood Hits	154	Target Neighborhood Hits	364	Shared Neighborhood Hits	10
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

FGD2_MOUSE
θ value	0.813845 (rank : 72)	NC score	0.079851 (rank : 101)
Query Neighborhood Hits	154	Target Neighborhood Hits	163	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FLNB_MOUSE
θ value	0.813845 (rank : 73)	NC score	0.028730 (rank : 171)
Query Neighborhood Hits	154	Target Neighborhood Hits	126	Shared Neighborhood Hits	7
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

RHG09_HUMAN
θ value	0.813845 (rank : 74)	NC score	0.044343 (rank : 149)
Query Neighborhood Hits	154	Target Neighborhood Hits	186	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

CENB1_HUMAN
θ value	1.06291 (rank : 75)	NC score	0.089445 (rank : 92)
Query Neighborhood Hits	154	Target Neighborhood Hits	383	Shared Neighborhood Hits	41
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CEND3_MOUSE
θ value	1.06291 (rank : 76)	NC score	0.073885 (rank : 107)
Query Neighborhood Hits	154	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CSPG5_MOUSE
θ value	1.06291 (rank : 77)	NC score	0.037958 (rank : 162)
Query Neighborhood Hits	154	Target Neighborhood Hits	211	Shared Neighborhood Hits	5
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

DYN2_HUMAN
θ value	1.06291 (rank : 78)	NC score	0.169156 (rank : 44)
Query Neighborhood Hits	154	Target Neighborhood Hits	112	Shared Neighborhood Hits	40
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
θ value	1.06291 (rank : 79)	NC score	0.167116 (rank : 46)
Query Neighborhood Hits	154	Target Neighborhood Hits	104	Shared Neighborhood Hits	35
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

MPDZ_HUMAN
θ value	1.06291 (rank : 80)	NC score	0.055734 (rank : 127)
Query Neighborhood Hits	154	Target Neighborhood Hits	261	Shared Neighborhood Hits	19
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

ACK1_HUMAN
θ value	1.38821 (rank : 81)	NC score	0.008430 (rank : 209)
Query Neighborhood Hits	154	Target Neighborhood Hits	1140	Shared Neighborhood Hits	29
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

CO8B_MOUSE
θ value	1.38821 (rank : 82)	NC score	0.018067 (rank : 194)
Query Neighborhood Hits	154	Target Neighborhood Hits	224	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

EPN3_HUMAN
θ value	1.38821 (rank : 83)	NC score	0.026278 (rank : 178)
Query Neighborhood Hits	154	Target Neighborhood Hits	197	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H201, Q9BVN6, Q9NWK2	Gene names	EPN3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

FARP2_HUMAN
θ value	1.38821 (rank : 84)	NC score	0.112011 (rank : 77)
Query Neighborhood Hits	154	Target Neighborhood Hits	240	Shared Neighborhood Hits	41
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FMO4_MOUSE
θ value	1.38821 (rank : 85)	NC score	0.017652 (rank : 195)
Query Neighborhood Hits	154	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VHG0	Gene names	Fmo4
Domain Architecture	No domain graphic available
Description	Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC 1.14.13.8) (Hepatic flavin-containing monooxygenase 4) (FMO 4) (Dimethylaniline oxidase 4).

SF3B1_HUMAN
θ value	1.38821 (rank : 86)	NC score	0.061712 (rank : 122)
Query Neighborhood Hits	154	Target Neighborhood Hits	341	Shared Neighborhood Hits	17
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
θ value	1.38821 (rank : 87)	NC score	0.061672 (rank : 123)
Query Neighborhood Hits	154	Target Neighborhood Hits	352	Shared Neighborhood Hits	17
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

MLL3_HUMAN
θ value	1.81305 (rank : 88)	NC score	0.027487 (rank : 172)
Query Neighborhood Hits	154	Target Neighborhood Hits	1644	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

REXO1_MOUSE
θ value	1.81305 (rank : 89)	NC score	0.041431 (rank : 156)
Query Neighborhood Hits	154	Target Neighborhood Hits	166	Shared Neighborhood Hits	13
SwissProt Accessions	Q7TT28, Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29	Gene names	Rexo1, Kiaa1138, Tceb3bp1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1).

SAM14_MOUSE
θ value	1.81305 (rank : 90)	NC score	0.118761 (rank : 72)
Query Neighborhood Hits	154	Target Neighborhood Hits	91	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K070, Q5SWB7, Q8BHE2, Q8C8N5	Gene names	Samd14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

FLNB_HUMAN
θ value	2.36792 (rank : 91)	NC score	0.026792 (rank : 175)
Query Neighborhood Hits	154	Target Neighborhood Hits	111	Shared Neighborhood Hits	8
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

MY18A_MOUSE
θ value	2.36792 (rank : 92)	NC score	0.022281 (rank : 189)
Query Neighborhood Hits	154	Target Neighborhood Hits	1989	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PEX6_MOUSE
θ value	2.36792 (rank : 93)	NC score	0.011332 (rank : 205)
Query Neighborhood Hits	154	Target Neighborhood Hits	94	Shared Neighborhood Hits	2
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

PSD3_HUMAN
θ value	2.36792 (rank : 94)	NC score	0.255173 (rank : 19)
Query Neighborhood Hits	154	Target Neighborhood Hits	75	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

VPS53_HUMAN
θ value	2.36792 (rank : 95)	NC score	0.043576 (rank : 150)
Query Neighborhood Hits	154	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VIR6, Q8WYW3, Q9BRR2, Q9BY02, Q9NV25	Gene names	VPS53
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 53.

VPS53_MOUSE
θ value	2.36792 (rank : 96)	NC score	0.042895 (rank : 152)
Query Neighborhood Hits	154	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CCB4, Q8C7U0, Q8CIA1, Q9CX82, Q9D6T7	Gene names	Vps53
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 53.

XRCC4_MOUSE
θ value	2.36792 (rank : 97)	NC score	0.031348 (rank : 169)
Query Neighborhood Hits	154	Target Neighborhood Hits	104	Shared Neighborhood Hits	2
SwissProt Accessions	Q924T3, Q8BKC9, Q8BU02, Q9D6U6	Gene names	Xrcc4
Domain Architecture
Description	DNA-repair protein XRCC4 (X-ray repair cross-complementing protein 4).

AP180_HUMAN
θ value	3.0926 (rank : 98)	NC score	0.035082 (rank : 165)
Query Neighborhood Hits	154	Target Neighborhood Hits	183	Shared Neighborhood Hits	16
SwissProt Accessions	O60641, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7	Gene names	SNAP91, KIAA0656
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein).

CENA1_HUMAN
θ value	3.0926 (rank : 99)	NC score	0.081129 (rank : 97)
Query Neighborhood Hits	154	Target Neighborhood Hits	87	Shared Neighborhood Hits	34
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CENB5_HUMAN
θ value	3.0926 (rank : 100)	NC score	0.097044 (rank : 89)
Query Neighborhood Hits	154	Target Neighborhood Hits	395	Shared Neighborhood Hits	42
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

DOC10_HUMAN
θ value	3.0926 (rank : 101)	NC score	0.047415 (rank : 147)
Query Neighborhood Hits	154	Target Neighborhood Hits	88	Shared Neighborhood Hits	19
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

FMN2_HUMAN
θ value	3.0926 (rank : 102)	NC score	0.036721 (rank : 163)
Query Neighborhood Hits	154	Target Neighborhood Hits	484	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

GTSE1_MOUSE
θ value	3.0926 (rank : 103)	NC score	0.038573 (rank : 160)
Query Neighborhood Hits	154	Target Neighborhood Hits	245	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

HSF1_MOUSE
θ value	3.0926 (rank : 104)	NC score	0.023591 (rank : 183)
Query Neighborhood Hits	154	Target Neighborhood Hits	267	Shared Neighborhood Hits	13
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

MAGI1_HUMAN
θ value	3.0926 (rank : 105)	NC score	0.079670 (rank : 102)
Query Neighborhood Hits	154	Target Neighborhood Hits	388	Shared Neighborhood Hits	24
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

PCNT_MOUSE
θ value	3.0926 (rank : 106)	NC score	0.025031 (rank : 181)
Query Neighborhood Hits	154	Target Neighborhood Hits	1207	Shared Neighborhood Hits	22
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

PHLB1_MOUSE
θ value	3.0926 (rank : 107)	NC score	0.103494 (rank : 85)
Query Neighborhood Hits	154	Target Neighborhood Hits	678	Shared Neighborhood Hits	53
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

SMC4_HUMAN
θ value	3.0926 (rank : 108)	NC score	0.015486 (rank : 198)
Query Neighborhood Hits	154	Target Neighborhood Hits	937	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

STC2_HUMAN
θ value	3.0926 (rank : 109)	NC score	0.027384 (rank : 173)
Query Neighborhood Hits	154	Target Neighborhood Hits	70	Shared Neighborhood Hits	4
SwissProt Accessions	O76061	Gene names	STC2
Domain Architecture
Description	Stanniocalcin-2 precursor (STC-2) (Stanniocalcin-related protein) (STCRP) (STC-related protein).

TINF2_MOUSE
θ value	3.0926 (rank : 110)	NC score	0.031865 (rank : 167)
Query Neighborhood Hits	154	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXG9	Gene names	Tinf2, Tin2
Domain Architecture	No domain graphic available
Description	TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2).

CENB2_HUMAN
θ value	4.03905 (rank : 111)	NC score	0.102407 (rank : 86)
Query Neighborhood Hits	154	Target Neighborhood Hits	425	Shared Neighborhood Hits	41
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

EPHAA_HUMAN
θ value	4.03905 (rank : 112)	NC score	0.004012 (rank : 213)
Query Neighborhood Hits	154	Target Neighborhood Hits	960	Shared Neighborhood Hits	11
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

GP152_MOUSE
θ value	4.03905 (rank : 113)	NC score	0.010430 (rank : 207)
Query Neighborhood Hits	154	Target Neighborhood Hits	607	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

MYO15_HUMAN
θ value	4.03905 (rank : 114)	NC score	0.024251 (rank : 182)
Query Neighborhood Hits	154	Target Neighborhood Hits	671	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

OTP_MOUSE
θ value	4.03905 (rank : 115)	NC score	0.004823 (rank : 211)
Query Neighborhood Hits	154	Target Neighborhood Hits	387	Shared Neighborhood Hits	5
SwissProt Accessions	O09113	Gene names	Otp
Domain Architecture
Description	Homeobox protein orthopedia.

REXO1_HUMAN
θ value	4.03905 (rank : 116)	NC score	0.048119 (rank : 145)
Query Neighborhood Hits	154	Target Neighborhood Hits	242	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

RFIP5_MOUSE
θ value	4.03905 (rank : 117)	NC score	0.022525 (rank : 188)
Query Neighborhood Hits	154	Target Neighborhood Hits	126	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

BSN_MOUSE
θ value	5.27518 (rank : 118)	NC score	0.046774 (rank : 148)
Query Neighborhood Hits	154	Target Neighborhood Hits	2057	Shared Neighborhood Hits	65
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

EVPL_MOUSE
θ value	5.27518 (rank : 119)	NC score	0.014963 (rank : 199)
Query Neighborhood Hits	154	Target Neighborhood Hits	952	Shared Neighborhood Hits	19
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

FGD4_HUMAN
θ value	5.27518 (rank : 120)	NC score	0.080483 (rank : 100)
Query Neighborhood Hits	154	Target Neighborhood Hits	219	Shared Neighborhood Hits	30
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

MACF1_HUMAN
θ value	5.27518 (rank : 121)	NC score	0.014482 (rank : 200)
Query Neighborhood Hits	154	Target Neighborhood Hits	1341	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

OSBP2_HUMAN
θ value	5.27518 (rank : 122)	NC score	0.067053 (rank : 114)
Query Neighborhood Hits	154	Target Neighborhood Hits	154	Shared Neighborhood Hits	37
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

PCY1B_HUMAN
θ value	5.27518 (rank : 123)	NC score	0.022829 (rank : 186)
Query Neighborhood Hits	154	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y5K3, O60621, Q86XC9	Gene names	PCYT1B, CCTB
Domain Architecture
Description	Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (Phosphorylcholine transferase B) (CTP:phosphocholine cytidylyltransferase B) (CT B) (CCT B) (CCT-beta).

PCY1B_MOUSE
θ value	5.27518 (rank : 124)	NC score	0.022993 (rank : 185)
Query Neighborhood Hits	154	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	Q811Q9, Q3UEW0, Q80Y63, Q811Q8, Q8BKD2, Q8C085	Gene names	Pcyt1b
Domain Architecture	No domain graphic available
Description	Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (Phosphorylcholine transferase B) (CTP:phosphocholine cytidylyltransferase B) (CT B) (CCT B) (CCT-beta).

RECQ5_HUMAN
θ value	5.27518 (rank : 125)	NC score	0.017180 (rank : 196)
Query Neighborhood Hits	154	Target Neighborhood Hits	390	Shared Neighborhood Hits	15
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

SYNE1_HUMAN
θ value	5.27518 (rank : 126)	NC score	0.021805 (rank : 190)
Query Neighborhood Hits	154	Target Neighborhood Hits	1484	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

AP180_MOUSE
θ value	6.88961 (rank : 127)	NC score	0.031351 (rank : 168)
Query Neighborhood Hits	154	Target Neighborhood Hits	194	Shared Neighborhood Hits	15
SwissProt Accessions	Q61548, Q61547	Gene names	Snap91
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein) (Phosphoprotein F1- 20).

BSN_HUMAN
θ value	6.88961 (rank : 128)	NC score	0.049392 (rank : 144)
Query Neighborhood Hits	154	Target Neighborhood Hits	1537	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CBL_MOUSE
θ value	6.88961 (rank : 129)	NC score	0.013041 (rank : 203)
Query Neighborhood Hits	154	Target Neighborhood Hits	426	Shared Neighborhood Hits	15
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

DAPP1_MOUSE
θ value	6.88961 (rank : 130)	NC score	0.162904 (rank : 47)
Query Neighborhood Hits	154	Target Neighborhood Hits	225	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

EPHA8_MOUSE
θ value	6.88961 (rank : 131)	NC score	0.002186 (rank : 214)
Query Neighborhood Hits	154	Target Neighborhood Hits	969	Shared Neighborhood Hits	10
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

FANCE_HUMAN
θ value	6.88961 (rank : 132)	NC score	0.025181 (rank : 179)
Query Neighborhood Hits	154	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HB96, Q4ZGH2	Gene names	FANCE
Domain Architecture	No domain graphic available
Description	Fanconi anemia group E protein (Protein FACE).

KCNN3_HUMAN
θ value	6.88961 (rank : 133)	NC score	0.010590 (rank : 206)
Query Neighborhood Hits	154	Target Neighborhood Hits	216	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UGI6, O43517	Gene names	KCNN3, K3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa3).

LR37A_HUMAN
θ value	6.88961 (rank : 134)	NC score	0.020191 (rank : 192)
Query Neighborhood Hits	154	Target Neighborhood Hits	720	Shared Neighborhood Hits	27
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

MAML2_HUMAN
θ value	6.88961 (rank : 135)	NC score	0.027117 (rank : 174)
Query Neighborhood Hits	154	Target Neighborhood Hits	360	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IZL2, Q6AI23, Q6Y3A3, Q8IUL3, Q96JK6	Gene names	MAML2, KIAA1819
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 2 (Mam-2).

MBD5_HUMAN
θ value	6.88961 (rank : 136)	NC score	0.023307 (rank : 184)
Query Neighborhood Hits	154	Target Neighborhood Hits	176	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

MTSS1_MOUSE
θ value	6.88961 (rank : 137)	NC score	0.025137 (rank : 180)
Query Neighborhood Hits	154	Target Neighborhood Hits	592	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

PCLO_HUMAN
θ value	6.88961 (rank : 138)	NC score	0.041790 (rank : 153)
Query Neighborhood Hits	154	Target Neighborhood Hits	2046	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RIMB2_HUMAN
θ value	6.88961 (rank : 139)	NC score	0.014066 (rank : 201)
Query Neighborhood Hits	154	Target Neighborhood Hits	263	Shared Neighborhood Hits	10
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SHAN1_HUMAN
θ value	6.88961 (rank : 140)	NC score	0.064637 (rank : 116)
Query Neighborhood Hits	154	Target Neighborhood Hits	1041	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SMOO_HUMAN
θ value	6.88961 (rank : 141)	NC score	0.032435 (rank : 166)
Query Neighborhood Hits	154	Target Neighborhood Hits	391	Shared Neighborhood Hits	28
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

TARSH_HUMAN
θ value	6.88961 (rank : 142)	NC score	0.043545 (rank : 151)
Query Neighborhood Hits	154	Target Neighborhood Hits	768	Shared Neighborhood Hits	37
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TMM26_MOUSE
θ value	6.88961 (rank : 143)	NC score	0.020180 (rank : 193)
Query Neighborhood Hits	154	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q3UP23, Q8BN94	Gene names	Tmem26
Domain Architecture	No domain graphic available
Description	Transmembrane protein 26.

AMOL1_MOUSE
θ value	8.99809 (rank : 144)	NC score	0.009559 (rank : 208)
Query Neighborhood Hits	154	Target Neighborhood Hits	445	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D4H4, Q571F1	Gene names	Amotl1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

ASTL_HUMAN
θ value	8.99809 (rank : 145)	NC score	0.012744 (rank : 204)
Query Neighborhood Hits	154	Target Neighborhood Hits	252	Shared Neighborhood Hits	13
SwissProt Accessions	Q6HA08	Gene names	ASTL
Domain Architecture	No domain graphic available
Description	Astacin-like metalloendopeptidase precursor (EC 3.4.-.-) (Oocyte astacin) (Ovastacin).

FMN2_MOUSE
θ value	8.99809 (rank : 146)	NC score	0.026395 (rank : 177)
Query Neighborhood Hits	154	Target Neighborhood Hits	349	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

INADL_MOUSE
θ value	8.99809 (rank : 147)	NC score	0.041775 (rank : 155)
Query Neighborhood Hits	154	Target Neighborhood Hits	290	Shared Neighborhood Hits	18
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

LRC27_MOUSE
θ value	8.99809 (rank : 148)	NC score	0.007674 (rank : 210)
Query Neighborhood Hits	154	Target Neighborhood Hits	290	Shared Neighborhood Hits	6
SwissProt Accessions	Q80YS5, Q9D6Z2	Gene names	Lrrc27
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 27.

ORC1_MOUSE
θ value	8.99809 (rank : 149)	NC score	0.016015 (rank : 197)
Query Neighborhood Hits	154	Target Neighborhood Hits	65	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z1N2	Gene names	Orc1l, Orc1
Domain Architecture
Description	Origin recognition complex subunit 1.

RASA2_HUMAN
θ value	8.99809 (rank : 150)	NC score	0.040883 (rank : 158)
Query Neighborhood Hits	154	Target Neighborhood Hits	157	Shared Neighborhood Hits	29
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RLF_HUMAN
θ value	8.99809 (rank : 151)	NC score	-0.000246 (rank : 216)
Query Neighborhood Hits	154	Target Neighborhood Hits	775	Shared Neighborhood Hits	4
SwissProt Accessions	Q13129, Q9NU60	Gene names	RLF
Domain Architecture	No domain graphic available
Description	Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15- related protein).

SNX15_MOUSE
θ value	8.99809 (rank : 152)	NC score	0.013224 (rank : 202)
Query Neighborhood Hits	154	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WE1	Gene names	Snx15
Domain Architecture	No domain graphic available
Description	Sorting nexin-15.

ZN385_HUMAN
θ value	8.99809 (rank : 153)	NC score	0.022591 (rank : 187)
Query Neighborhood Hits	154	Target Neighborhood Hits	614	Shared Neighborhood Hits	22
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

ZO3_MOUSE
θ value	8.99809 (rank : 154)	NC score	0.020747 (rank : 191)
Query Neighborhood Hits	154	Target Neighborhood Hits	224	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

3BP2_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.143426 (rank : 64)
Query Neighborhood Hits	154	Target Neighborhood Hits	296	Shared Neighborhood Hits	36
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.144137 (rank : 63)
Query Neighborhood Hits	154	Target Neighborhood Hits	142	Shared Neighborhood Hits	33
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

AB1IP_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.052931 (rank : 136)
Query Neighborhood Hits	154	Target Neighborhood Hits	213	Shared Neighborhood Hits	33
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

BIG1_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.184382 (rank : 36)
Query Neighborhood Hits	154	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BIG2_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.184954 (rank : 35)
Query Neighborhood Hits	154	Target Neighborhood Hits	66	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

C43BP_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.054137 (rank : 133)
Query Neighborhood Hits	154	Target Neighborhood Hits	87	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.056803 (rank : 126)
Query Neighborhood Hits	154	Target Neighborhood Hits	91	Shared Neighborhood Hits	35
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CENA2_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.065032 (rank : 115)
Query Neighborhood Hits	154	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CEND1_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.083420 (rank : 96)
Query Neighborhood Hits	154	Target Neighborhood Hits	284	Shared Neighborhood Hits	52
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.062396 (rank : 120)
Query Neighborhood Hits	154	Target Neighborhood Hits	260	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND2_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.076242 (rank : 104)
Query Neighborhood Hits	154	Target Neighborhood Hits	166	Shared Neighborhood Hits	40
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

DAPP1_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.152308 (rank : 57)
Query Neighborhood Hits	154	Target Neighborhood Hits	227	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DGKK_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.050473 (rank : 141)
Query Neighborhood Hits	154	Target Neighborhood Hits	378	Shared Neighborhood Hits	31
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DNM1L_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.064282 (rank : 118)
Query Neighborhood Hits	154	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	O00429, O14541, O60709, Q7L6B3, Q8TBT7, Q9BWM1, Q9Y5J2	Gene names	DNM1L, DLP1, DRP1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-like protein) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-related protein 1) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV).

DNM1L_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.064296 (rank : 117)
Query Neighborhood Hits	154	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K1M6, Q8BNQ5, Q8BQ64, Q8CGD0, Q8K1A1	Gene names	Dnm1l, Drp1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-related protein 1) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple).

FBX8_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.168956 (rank : 45)
Query Neighborhood Hits	154	Target Neighborhood Hits	44	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

FBX8_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.169591 (rank : 43)
Query Neighborhood Hits	154	Target Neighborhood Hits	45	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FGD1_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.087899 (rank : 94)
Query Neighborhood Hits	154	Target Neighborhood Hits	367	Shared Neighborhood Hits	42
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.089166 (rank : 93)
Query Neighborhood Hits	154	Target Neighborhood Hits	387	Shared Neighborhood Hits	43
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.070601 (rank : 112)
Query Neighborhood Hits	154	Target Neighborhood Hits	151	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD3_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.055674 (rank : 128)
Query Neighborhood Hits	154	Target Neighborhood Hits	249	Shared Neighborhood Hits	19
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.071930 (rank : 110)
Query Neighborhood Hits	154	Target Neighborhood Hits	257	Shared Neighborhood Hits	31
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.076812 (rank : 103)
Query Neighborhood Hits	154	Target Neighborhood Hits	227	Shared Neighborhood Hits	35
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

GBF1_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.192006 (rank : 33)
Query Neighborhood Hits	154	Target Neighborhood Hits	142	Shared Neighborhood Hits	18
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

GNRP_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.106620 (rank : 81)
Query Neighborhood Hits	154	Target Neighborhood Hits	239	Shared Neighborhood Hits	37
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

IQEC1_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.162494 (rank : 48)
Query Neighborhood Hits	154	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC1_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.161528 (rank : 49)
Query Neighborhood Hits	154	Target Neighborhood Hits	54	Shared Neighborhood Hits	15
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

IQEC2_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.155305 (rank : 53)
Query Neighborhood Hits	154	Target Neighborhood Hits	403	Shared Neighborhood Hits	31
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.155897 (rank : 52)
Query Neighborhood Hits	154	Target Neighborhood Hits	417	Shared Neighborhood Hits	31
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC3_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.173293 (rank : 42)
Query Neighborhood Hits	154	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC3_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.176910 (rank : 39)
Query Neighborhood Hits	154	Target Neighborhood Hits	274	Shared Neighborhood Hits	27
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

MAGI1_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.075493 (rank : 106)
Query Neighborhood Hits	154	Target Neighborhood Hits	403	Shared Neighborhood Hits	23
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MTMRD_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.080530 (rank : 99)
Query Neighborhood Hits	154	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

MX1_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.050645 (rank : 140)
Query Neighborhood Hits	154	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	P20591	Gene names	MX1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Interferon-regulated resistance GTP-binding protein MxA) (Interferon-induced protein p78) (IFI-78K).

NEB1_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.053532 (rank : 135)
Query Neighborhood Hits	154	Target Neighborhood Hits	829	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

OSBP1_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.072927 (rank : 109)
Query Neighborhood Hits	154	Target Neighborhood Hits	180	Shared Neighborhood Hits	36
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

PHLB2_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.071451 (rank : 111)
Query Neighborhood Hits	154	Target Neighborhood Hits	964	Shared Neighborhood Hits	45
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.073136 (rank : 108)
Query Neighborhood Hits	154	Target Neighborhood Hits	1016	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PKHA1_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.200823 (rank : 29)
Query Neighborhood Hits	154	Target Neighborhood Hits	127	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.197512 (rank : 31)
Query Neighborhood Hits	154	Target Neighborhood Hits	120	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.177213 (rank : 38)
Query Neighborhood Hits	154	Target Neighborhood Hits	119	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.189645 (rank : 34)
Query Neighborhood Hits	154	Target Neighborhood Hits	116	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA3_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.075895 (rank : 105)
Query Neighborhood Hits	154	Target Neighborhood Hits	66	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.080585 (rank : 98)
Query Neighborhood Hits	154	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHB1_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.106797 (rank : 80)
Query Neighborhood Hits	154	Target Neighborhood Hits	46	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB1_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.091360 (rank : 91)
Query Neighborhood Hits	154	Target Neighborhood Hits	47	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB2_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.114479 (rank : 75)
Query Neighborhood Hits	154	Target Neighborhood Hits	54	Shared Neighborhood Hits	30
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHB2_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.105102 (rank : 82)
Query Neighborhood Hits	154	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHF1_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.050194 (rank : 142)
Query Neighborhood Hits	154	Target Neighborhood Hits	80	Shared Neighborhood Hits	13
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.052198 (rank : 137)
Query Neighborhood Hits	154	Target Neighborhood Hits	75	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.055269 (rank : 130)
Query Neighborhood Hits	154	Target Neighborhood Hits	77	Shared Neighborhood Hits	16
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PLEK2_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.150655 (rank : 58)
Query Neighborhood Hits	154	Target Neighborhood Hits	101	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.150157 (rank : 59)
Query Neighborhood Hits	154	Target Neighborhood Hits	96	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

RAPH1_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.051075 (rank : 139)
Query Neighborhood Hits	154	Target Neighborhood Hits	593	Shared Neighborhood Hits	38
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RASA3_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.050133 (rank : 143)
Query Neighborhood Hits	154	Target Neighborhood Hits	166	Shared Neighborhood Hits	33
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

SAM10_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.057999 (rank : 125)
Query Neighborhood Hits	154	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYL1	Gene names	SAMD10, C20orf136
Domain Architecture
Description	Sterile alpha motif domain-containing protein 10.

SAM10_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.055294 (rank : 129)
Query Neighborhood Hits	154	Target Neighborhood Hits	23	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TST3	Gene names	Samd10
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 10.

SARM1_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.053840 (rank : 134)
Query Neighborhood Hits	154	Target Neighborhood Hits	58	Shared Neighborhood Hits	7
SwissProt Accessions	Q6SZW1, O60277, Q7LGG3, Q9NXY5	Gene names	SARM1, KIAA0524, SARM
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Tir-1 homolog).

SARM1_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.059753 (rank : 124)
Query Neighborhood Hits	154	Target Neighborhood Hits	54	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PDS3, Q5SYG5, Q5SYG6, Q6A054, Q6SZW0, Q8BRI9	Gene names	Sarm1, Kiaa0524
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog).

SRRM1_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.054789 (rank : 131)
Query Neighborhood Hits	154	Target Neighborhood Hits	966	Shared Neighborhood Hits	49
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SRRM2_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.051246 (rank : 138)
Query Neighborhood Hits	154	Target Neighborhood Hits	1296	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

TBCD2_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.062262 (rank : 121)
Query Neighborhood Hits	154	Target Neighborhood Hits	419	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

Hits sorted by NC score

CNKR1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	154	Target Neighborhood Hits	154	Shared Neighborhood Hits	154
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_MOUSE
NC score	0.751612 (rank : 2)	θ value	5.95217e-44 (rank : 3)
Query Neighborhood Hits	154	Target Neighborhood Hits	197	Shared Neighborhood Hits	64
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.751337 (rank : 3)	θ value	5.95217e-44 (rank : 2)
Query Neighborhood Hits	154	Target Neighborhood Hits	197	Shared Neighborhood Hits	64
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

PKHA4_MOUSE
NC score	0.532983 (rank : 4)	θ value	2.28291e-11 (rank : 4)
Query Neighborhood Hits	154	Target Neighborhood Hits	202	Shared Neighborhood Hits	61
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_HUMAN
NC score	0.510786 (rank : 5)	θ value	3.29651e-10 (rank : 5)
Query Neighborhood Hits	154	Target Neighborhood Hits	283	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA6_HUMAN
NC score	0.425015 (rank : 6)	θ value	7.1131e-05 (rank : 15)
Query Neighborhood Hits	154	Target Neighborhood Hits	556	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA5_HUMAN
NC score	0.419910 (rank : 7)	θ value	1.69304e-06 (rank : 12)
Query Neighborhood Hits	154	Target Neighborhood Hits	455	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

CYH3_HUMAN
NC score	0.407232 (rank : 8)	θ value	2.61198e-07 (rank : 8)
Query Neighborhood Hits	154	Target Neighborhood Hits	137	Shared Neighborhood Hits	60
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

PKHA6_MOUSE
NC score	0.406545 (rank : 9)	θ value	0.000270298 (rank : 16)
Query Neighborhood Hits	154	Target Neighborhood Hits	591	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CYH1_HUMAN
NC score	0.404290 (rank : 10)	θ value	2.61198e-07 (rank : 6)
Query Neighborhood Hits	154	Target Neighborhood Hits	184	Shared Neighborhood Hits	63
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH2_HUMAN
NC score	0.404142 (rank : 11)	θ value	9.92553e-07 (rank : 9)
Query Neighborhood Hits	154	Target Neighborhood Hits	175	Shared Neighborhood Hits	61
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.403951 (rank : 12)	θ value	9.92553e-07 (rank : 10)
Query Neighborhood Hits	154	Target Neighborhood Hits	171	Shared Neighborhood Hits	62
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH1_MOUSE
NC score	0.403559 (rank : 13)	θ value	2.61198e-07 (rank : 7)
Query Neighborhood Hits	154	Target Neighborhood Hits	176	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH4_HUMAN
NC score	0.401760 (rank : 14)	θ value	4.92598e-06 (rank : 14)
Query Neighborhood Hits	154	Target Neighborhood Hits	135	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH3_MOUSE
NC score	0.399820 (rank : 15)	θ value	1.69304e-06 (rank : 11)
Query Neighborhood Hits	154	Target Neighborhood Hits	148	Shared Neighborhood Hits	60
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH4_MOUSE
NC score	0.398844 (rank : 16)	θ value	3.77169e-06 (rank : 13)
Query Neighborhood Hits	154	Target Neighborhood Hits	134	Shared Neighborhood Hits	59
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

PLEK_HUMAN
NC score	0.273033 (rank : 17)	θ value	0.0252991 (rank : 32)
Query Neighborhood Hits	154	Target Neighborhood Hits	110	Shared Neighborhood Hits	52
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PSD4_HUMAN
NC score	0.266161 (rank : 18)	θ value	0.000270298 (rank : 17)
Query Neighborhood Hits	154	Target Neighborhood Hits	178	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

PSD3_HUMAN
NC score	0.255173 (rank : 19)	θ value	2.36792 (rank : 94)
Query Neighborhood Hits	154	Target Neighborhood Hits	75	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PLEK_MOUSE
NC score	0.251608 (rank : 20)	θ value	0.125558 (rank : 48)
Query Neighborhood Hits	154	Target Neighborhood Hits	109	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PSD4_MOUSE
NC score	0.236210 (rank : 21)	θ value	0.365318 (rank : 62)
Query Neighborhood Hits	154	Target Neighborhood Hits	78	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

GAB1_HUMAN
NC score	0.225505 (rank : 22)	θ value	0.000602161 (rank : 18)
Query Neighborhood Hits	154	Target Neighborhood Hits	279	Shared Neighborhood Hits	43
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB1_MOUSE
NC score	0.225241 (rank : 23)	θ value	0.00298849 (rank : 22)
Query Neighborhood Hits	154	Target Neighborhood Hits	233	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB2_MOUSE
NC score	0.223519 (rank : 24)	θ value	0.0736092 (rank : 44)
Query Neighborhood Hits	154	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GAB2_HUMAN
NC score	0.217854 (rank : 25)	θ value	0.125558 (rank : 47)
Query Neighborhood Hits	154	Target Neighborhood Hits	188	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

RHG25_HUMAN
NC score	0.215600 (rank : 26)	θ value	0.00228821 (rank : 20)
Query Neighborhood Hits	154	Target Neighborhood Hits	550	Shared Neighborhood Hits	64
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

MRIP_MOUSE
NC score	0.213503 (rank : 27)	θ value	0.00134147 (rank : 19)
Query Neighborhood Hits	154	Target Neighborhood Hits	569	Shared Neighborhood Hits	57
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

RHG25_MOUSE
NC score	0.210548 (rank : 28)	θ value	0.00390308 (rank : 24)
Query Neighborhood Hits	154	Target Neighborhood Hits	492	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

PKHA1_HUMAN
NC score	0.200823 (rank : 29)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	154	Target Neighborhood Hits	127	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

MRIP_HUMAN
NC score	0.200363 (rank : 30)	θ value	0.0193708 (rank : 30)
Query Neighborhood Hits	154	Target Neighborhood Hits	578	Shared Neighborhood Hits	56
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

PKHA1_MOUSE
NC score	0.197512 (rank : 31)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	154	Target Neighborhood Hits	120	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

ANLN_HUMAN
NC score	0.195356 (rank : 32)	θ value	0.0961366 (rank : 45)
Query Neighborhood Hits	154	Target Neighborhood Hits	222	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

GBF1_HUMAN
NC score	0.192006 (rank : 33)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	154	Target Neighborhood Hits	142	Shared Neighborhood Hits	18
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

PKHA2_MOUSE
NC score	0.189645 (rank : 34)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	154	Target Neighborhood Hits	116	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

BIG2_HUMAN
NC score	0.184954 (rank : 35)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	154	Target Neighborhood Hits	66	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

BIG1_HUMAN
NC score	0.184382 (rank : 36)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	154	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

TARA_MOUSE
NC score	0.182995 (rank : 37)	θ value	0.00228821 (rank : 21)
Query Neighborhood Hits	154	Target Neighborhood Hits	1133	Shared Neighborhood Hits	74
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

PKHA2_HUMAN
NC score	0.177213 (rank : 38)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	154	Target Neighborhood Hits	119	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

IQEC3_MOUSE
NC score	0.176910 (rank : 39)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	154	Target Neighborhood Hits	274	Shared Neighborhood Hits	27
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

ANLN_MOUSE
NC score	0.175339 (rank : 40)	θ value	0.0563607 (rank : 38)
Query Neighborhood Hits	154	Target Neighborhood Hits	297	Shared Neighborhood Hits	27
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

DYN3_HUMAN
NC score	0.173514 (rank : 41)	θ value	0.0113563 (rank : 25)
Query Neighborhood Hits	154	Target Neighborhood Hits	158	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

IQEC3_HUMAN
NC score	0.173293 (rank : 42)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	154	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

FBX8_MOUSE
NC score	0.169591 (rank : 43)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	154	Target Neighborhood Hits	45	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

DYN2_HUMAN
NC score	0.169156 (rank : 44)	θ value	1.06291 (rank : 78)
Query Neighborhood Hits	154	Target Neighborhood Hits	112	Shared Neighborhood Hits	40
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

FBX8_HUMAN
NC score	0.168956 (rank : 45)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	154	Target Neighborhood Hits	44	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

DYN2_MOUSE
NC score	0.167116 (rank : 46)	θ value	1.06291 (rank : 79)
Query Neighborhood Hits	154	Target Neighborhood Hits	104	Shared Neighborhood Hits	35
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

DAPP1_MOUSE
NC score	0.162904 (rank : 47)	θ value	6.88961 (rank : 130)
Query Neighborhood Hits	154	Target Neighborhood Hits	225	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

IQEC1_HUMAN
NC score	0.162494 (rank : 48)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	154	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC1_MOUSE
NC score	0.161528 (rank : 49)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	154	Target Neighborhood Hits	54	Shared Neighborhood Hits	15
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

DGKH_HUMAN
NC score	0.158287 (rank : 50)	θ value	0.125558 (rank : 46)
Query Neighborhood Hits	154	Target Neighborhood Hits	255	Shared Neighborhood Hits	52
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

FGD5_MOUSE
NC score	0.156301 (rank : 51)	θ value	0.279714 (rank : 56)
Query Neighborhood Hits	154	Target Neighborhood Hits	170	Shared Neighborhood Hits	35
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

IQEC2_MOUSE
NC score	0.155897 (rank : 52)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	154	Target Neighborhood Hits	417	Shared Neighborhood Hits	31
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_HUMAN
NC score	0.155305 (rank : 53)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	154	Target Neighborhood Hits	403	Shared Neighborhood Hits	31
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

DYN1_HUMAN
NC score	0.154191 (rank : 54)	θ value	0.0330416 (rank : 33)
Query Neighborhood Hits	154	Target Neighborhood Hits	216	Shared Neighborhood Hits	41
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_MOUSE
NC score	0.152735 (rank : 55)	θ value	0.0330416 (rank : 34)
Query Neighborhood Hits	154	Target Neighborhood Hits	168	Shared Neighborhood Hits	39
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

FGD5_HUMAN
NC score	0.152454 (rank : 56)	θ value	0.21417 (rank : 49)
Query Neighborhood Hits	154	Target Neighborhood Hits	235	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

DAPP1_HUMAN
NC score	0.152308 (rank : 57)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	154	Target Neighborhood Hits	227	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PLEK2_HUMAN
NC score	0.150655 (rank : 58)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	154	Target Neighborhood Hits	101	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
NC score	0.150157 (rank : 59)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	154	Target Neighborhood Hits	96	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

FGD6_MOUSE
NC score	0.149435 (rank : 60)	θ value	0.0193708 (rank : 28)
Query Neighborhood Hits	154	Target Neighborhood Hits	282	Shared Neighborhood Hits	41
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

SHAN2_HUMAN
NC score	0.148277 (rank : 61)	θ value	0.0563607 (rank : 41)
Query Neighborhood Hits	154	Target Neighborhood Hits	346	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

FGD6_HUMAN
NC score	0.145195 (rank : 62)	θ value	0.0330416 (rank : 36)
Query Neighborhood Hits	154	Target Neighborhood Hits	237	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

3BP2_MOUSE
NC score	0.144137 (rank : 63)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	154	Target Neighborhood Hits	142	Shared Neighborhood Hits	33
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_HUMAN
NC score	0.143426 (rank : 64)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	154	Target Neighborhood Hits	296	Shared Neighborhood Hits	36
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

SHAN2_MOUSE
NC score	0.140965 (rank : 65)	θ value	0.0563607 (rank : 42)
Query Neighborhood Hits	154	Target Neighborhood Hits	446	Shared Neighborhood Hits	32
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

TARA_HUMAN
NC score	0.140747 (rank : 66)	θ value	0.0563607 (rank : 43)
Query Neighborhood Hits	154	Target Neighborhood Hits	1626	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SAM14_HUMAN
NC score	0.140738 (rank : 67)	θ value	0.47712 (rank : 66)
Query Neighborhood Hits	154	Target Neighborhood Hits	81	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IZD0, Q8N2X0	Gene names	SAMD14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

DGKD_HUMAN
NC score	0.125030 (rank : 68)	θ value	0.0193708 (rank : 27)
Query Neighborhood Hits	154	Target Neighborhood Hits	231	Shared Neighborhood Hits	29
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

MAGI2_HUMAN
NC score	0.122428 (rank : 69)	θ value	0.0148317 (rank : 26)
Query Neighborhood Hits	154	Target Neighborhood Hits	373	Shared Neighborhood Hits	26
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

FARP1_HUMAN
NC score	0.121102 (rank : 70)	θ value	0.47712 (rank : 65)
Query Neighborhood Hits	154	Target Neighborhood Hits	241	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_MOUSE
NC score	0.120322 (rank : 71)	θ value	0.0330416 (rank : 35)
Query Neighborhood Hits	154	Target Neighborhood Hits	209	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

SAM14_MOUSE
NC score	0.118761 (rank : 72)	θ value	1.81305 (rank : 90)
Query Neighborhood Hits	154	Target Neighborhood Hits	91	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K070, Q5SWB7, Q8BHE2, Q8C8N5	Gene names	Samd14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

SWP70_HUMAN
NC score	0.118055 (rank : 73)	θ value	0.47712 (rank : 68)
Query Neighborhood Hits	154	Target Neighborhood Hits	973	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

MAGI2_MOUSE
NC score	0.115708 (rank : 74)	θ value	0.0193708 (rank : 29)
Query Neighborhood Hits	154	Target Neighborhood Hits	370	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

PKHB2_HUMAN
NC score	0.114479 (rank : 75)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	154	Target Neighborhood Hits	54	Shared Neighborhood Hits	30
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

SWP70_MOUSE
NC score	0.112602 (rank : 76)	θ value	0.365318 (rank : 64)
Query Neighborhood Hits	154	Target Neighborhood Hits	1097	Shared Neighborhood Hits	55
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

FARP2_HUMAN
NC score	0.112011 (rank : 77)	θ value	1.38821 (rank : 84)
Query Neighborhood Hits	154	Target Neighborhood Hits	240	Shared Neighborhood Hits	41
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

GNRP_MOUSE
NC score	0.111605 (rank : 78)	θ value	0.62314 (rank : 70)
Query Neighborhood Hits	154	Target Neighborhood Hits	191	Shared Neighborhood Hits	36
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

MTMR5_HUMAN
NC score	0.107653 (rank : 79)	θ value	0.0431538 (rank : 37)
Query Neighborhood Hits	154	Target Neighborhood Hits	141	Shared Neighborhood Hits	31
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

PKHB1_HUMAN
NC score	0.106797 (rank : 80)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	154	Target Neighborhood Hits	46	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

GNRP_HUMAN
NC score	0.106620 (rank : 81)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	154	Target Neighborhood Hits	239	Shared Neighborhood Hits	37
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

PKHB2_MOUSE
NC score	0.105102 (rank : 82)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	154	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PHLB1_HUMAN
NC score	0.104956 (rank : 83)	θ value	0.21417 (rank : 52)
Query Neighborhood Hits	154	Target Neighborhood Hits	1038	Shared Neighborhood Hits	58
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

RASA1_HUMAN
NC score	0.104713 (rank : 84)	θ value	0.21417 (rank : 53)
Query Neighborhood Hits	154	Target Neighborhood Hits	258	Shared Neighborhood Hits	31
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

PHLB1_MOUSE
NC score	0.103494 (rank : 85)	θ value	3.0926 (rank : 107)
Query Neighborhood Hits	154	Target Neighborhood Hits	678	Shared Neighborhood Hits	53
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

CENB2_HUMAN
NC score	0.102407 (rank : 86)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	154	Target Neighborhood Hits	425	Shared Neighborhood Hits	41
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

MYO10_HUMAN
NC score	0.098635 (rank : 87)	θ value	0.0563607 (rank : 39)
Query Neighborhood Hits	154	Target Neighborhood Hits	920	Shared Neighborhood Hits	65
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

TIAM1_HUMAN
NC score	0.097472 (rank : 88)	θ value	0.21417 (rank : 54)
Query Neighborhood Hits	154	Target Neighborhood Hits	225	Shared Neighborhood Hits	35
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

CENB5_HUMAN
NC score	0.097044 (rank : 89)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	154	Target Neighborhood Hits	395	Shared Neighborhood Hits	42
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

TIAM1_MOUSE
NC score	0.092954 (rank : 90)	θ value	0.21417 (rank : 55)
Query Neighborhood Hits	154	Target Neighborhood Hits	205	Shared Neighborhood Hits	32
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

PKHB1_MOUSE
NC score	0.091360 (rank : 91)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	154	Target Neighborhood Hits	47	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

CENB1_HUMAN
NC score	0.089445 (rank : 92)	θ value	1.06291 (rank : 75)
Query Neighborhood Hits	154	Target Neighborhood Hits	383	Shared Neighborhood Hits	41
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

FGD1_MOUSE
NC score	0.089166 (rank : 93)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	154	Target Neighborhood Hits	387	Shared Neighborhood Hits	43
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
NC score	0.087899 (rank : 94)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	154	Target Neighborhood Hits	367	Shared Neighborhood Hits	42
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

CEND3_HUMAN
NC score	0.083945 (rank : 95)	θ value	0.365318 (rank : 59)
Query Neighborhood Hits	154	Target Neighborhood Hits	275	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND1_HUMAN
NC score	0.083420 (rank : 96)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	154	Target Neighborhood Hits	284	Shared Neighborhood Hits	52
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CENA1_HUMAN
NC score	0.081129 (rank : 97)	θ value	3.0926 (rank : 99)
Query Neighborhood Hits	154	Target Neighborhood Hits	87	Shared Neighborhood Hits	34
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

PKHA3_MOUSE
NC score	0.080585 (rank : 98)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	154	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

MTMRD_HUMAN
NC score	0.080530 (rank : 99)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	154	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

FGD4_HUMAN
NC score	0.080483 (rank : 100)	θ value	5.27518 (rank : 120)
Query Neighborhood Hits	154	Target Neighborhood Hits	219	Shared Neighborhood Hits	30
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD2_MOUSE
NC score	0.079851 (rank : 101)	θ value	0.813845 (rank : 72)
Query Neighborhood Hits	154	Target Neighborhood Hits	163	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

MAGI1_HUMAN
NC score	0.079670 (rank : 102)	θ value	3.0926 (rank : 105)
Query Neighborhood Hits	154	Target Neighborhood Hits	388	Shared Neighborhood Hits	24
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

FGD4_MOUSE
NC score	0.076812 (rank : 103)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	154	Target Neighborhood Hits	227	Shared Neighborhood Hits	35
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

CEND2_HUMAN
NC score	0.076242 (rank : 104)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	154	Target Neighborhood Hits	166	Shared Neighborhood Hits	40
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

PKHA3_HUMAN
NC score	0.075895 (rank : 105)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	154	Target Neighborhood Hits	66	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

MAGI1_MOUSE
NC score	0.075493 (rank : 106)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	154	Target Neighborhood Hits	403	Shared Neighborhood Hits	23
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

CEND3_MOUSE
NC score	0.073885 (rank : 107)	θ value	1.06291 (rank : 76)
Query Neighborhood Hits	154	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

PHLB2_MOUSE
NC score	0.073136 (rank : 108)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	154	Target Neighborhood Hits	1016	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

OSBP1_HUMAN
NC score	0.072927 (rank : 109)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	154	Target Neighborhood Hits	180	Shared Neighborhood Hits	36
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

FGD3_MOUSE
NC score	0.071930 (rank : 110)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	154	Target Neighborhood Hits	257	Shared Neighborhood Hits	31
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

PHLB2_HUMAN
NC score	0.071451 (rank : 111)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	154	Target Neighborhood Hits	964	Shared Neighborhood Hits	45
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

FGD2_HUMAN
NC score	0.070601 (rank : 112)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	154	Target Neighborhood Hits	151	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

OGFR_HUMAN
NC score	0.069820 (rank : 113)	θ value	0.00390308 (rank : 23)
Query Neighborhood Hits	154	Target Neighborhood Hits	1582	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

OSBP2_HUMAN
NC score	0.067053 (rank : 114)	θ value	5.27518 (rank : 122)
Query Neighborhood Hits	154	Target Neighborhood Hits	154	Shared Neighborhood Hits	37
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

CENA2_HUMAN
NC score	0.065032 (rank : 115)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	154	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

SHAN1_HUMAN
NC score	0.064637 (rank : 116)	θ value	6.88961 (rank : 140)
Query Neighborhood Hits	154	Target Neighborhood Hits	1041	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

DNM1L_MOUSE
NC score	0.064296 (rank : 117)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	154	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K1M6, Q8BNQ5, Q8BQ64, Q8CGD0, Q8K1A1	Gene names	Dnm1l, Drp1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-related protein 1) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple).

DNM1L_HUMAN
NC score	0.064282 (rank : 118)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	154	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	O00429, O14541, O60709, Q7L6B3, Q8TBT7, Q9BWM1, Q9Y5J2	Gene names	DNM1L, DLP1, DRP1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-like protein) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-related protein 1) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV).

TNR1A_HUMAN
NC score	0.062576 (rank : 119)	θ value	0.0193708 (rank : 31)
Query Neighborhood Hits	154	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	P19438	Gene names	TNFRSF1A, TNFAR, TNFR1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55) (CD120a antigen) [Contains: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)].

CEND1_MOUSE
NC score	0.062396 (rank : 120)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	154	Target Neighborhood Hits	260	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

TBCD2_HUMAN
NC score	0.062262 (rank : 121)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	154	Target Neighborhood Hits	419	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

SF3B1_HUMAN
NC score	0.061712 (rank : 122)	θ value	1.38821 (rank : 86)
Query Neighborhood Hits	154	Target Neighborhood Hits	341	Shared Neighborhood Hits	17
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
NC score	0.061672 (rank : 123)	θ value	1.38821 (rank : 87)
Query Neighborhood Hits	154	Target Neighborhood Hits	352	Shared Neighborhood Hits	17
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SARM1_MOUSE
NC score	0.059753 (rank : 124)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	154	Target Neighborhood Hits	54	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PDS3, Q5SYG5, Q5SYG6, Q6A054, Q6SZW0, Q8BRI9	Gene names	Sarm1, Kiaa0524
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog).

SAM10_HUMAN
NC score	0.057999 (rank : 125)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	154	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYL1	Gene names	SAMD10, C20orf136
Domain Architecture
Description	Sterile alpha motif domain-containing protein 10.

C43BP_MOUSE
NC score	0.056803 (rank : 126)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	154	Target Neighborhood Hits	91	Shared Neighborhood Hits	35
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

MPDZ_HUMAN
NC score	0.055734 (rank : 127)	θ value	1.06291 (rank : 80)
Query Neighborhood Hits	154	Target Neighborhood Hits	261	Shared Neighborhood Hits	19
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

FGD3_HUMAN
NC score	0.055674 (rank : 128)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	154	Target Neighborhood Hits	249	Shared Neighborhood Hits	19
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

SAM10_MOUSE
NC score	0.055294 (rank : 129)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	154	Target Neighborhood Hits	23	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TST3	Gene names	Samd10
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 10.

PKHF2_MOUSE
NC score	0.055269 (rank : 130)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	154	Target Neighborhood Hits	77	Shared Neighborhood Hits	16
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

SRRM1_MOUSE
NC score	0.054789 (rank : 131)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	154	Target Neighborhood Hits	966	Shared Neighborhood Hits	49
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

NRX2B_HUMAN
NC score	0.054655 (rank : 132)	θ value	0.21417 (rank : 51)
Query Neighborhood Hits	154	Target Neighborhood Hits	481	Shared Neighborhood Hits	20
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

C43BP_HUMAN
NC score	0.054137 (rank : 133)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	154	Target Neighborhood Hits	87	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

SARM1_HUMAN
NC score	0.053840 (rank : 134)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	154	Target Neighborhood Hits	58	Shared Neighborhood Hits	7
SwissProt Accessions	Q6SZW1, O60277, Q7LGG3, Q9NXY5	Gene names	SARM1, KIAA0524, SARM
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Tir-1 homolog).

NEB1_HUMAN
NC score	0.053532 (rank : 135)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	154	Target Neighborhood Hits	829	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

AB1IP_HUMAN
NC score	0.052931 (rank : 136)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	154	Target Neighborhood Hits	213	Shared Neighborhood Hits	33
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

PKHF2_HUMAN
NC score	0.052198 (rank : 137)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	154	Target Neighborhood Hits	75	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

SRRM2_HUMAN
NC score	0.051246 (rank : 138)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	154	Target Neighborhood Hits	1296	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

RAPH1_HUMAN
NC score	0.051075 (rank : 139)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	154	Target Neighborhood Hits	593	Shared Neighborhood Hits	38
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

MX1_HUMAN
NC score	0.050645 (rank : 140)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	154	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	P20591	Gene names	MX1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Interferon-regulated resistance GTP-binding protein MxA) (Interferon-induced protein p78) (IFI-78K).

DGKK_HUMAN
NC score	0.050473 (rank : 141)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	154	Target Neighborhood Hits	378	Shared Neighborhood Hits	31
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

PKHF1_MOUSE
NC score	0.050194 (rank : 142)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	154	Target Neighborhood Hits	80	Shared Neighborhood Hits	13
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

RASA3_HUMAN
NC score	0.050133 (rank : 143)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	154	Target Neighborhood Hits	166	Shared Neighborhood Hits	33
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

BSN_HUMAN
NC score	0.049392 (rank : 144)	θ value	6.88961 (rank : 128)
Query Neighborhood Hits	154	Target Neighborhood Hits	1537	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

REXO1_HUMAN
NC score	0.048119 (rank : 145)	θ value	4.03905 (rank : 116)
Query Neighborhood Hits	154	Target Neighborhood Hits	242	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

BCL9_HUMAN
NC score	0.047527 (rank : 146)	θ value	0.365318 (rank : 58)
Query Neighborhood Hits	154	Target Neighborhood Hits	1008	Shared Neighborhood Hits	38
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

DOC10_HUMAN
NC score	0.047415 (rank : 147)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	154	Target Neighborhood Hits	88	Shared Neighborhood Hits	19
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

BSN_MOUSE
NC score	0.046774 (rank : 148)	θ value	5.27518 (rank : 118)
Query Neighborhood Hits	154	Target Neighborhood Hits	2057	Shared Neighborhood Hits	65
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

RHG09_HUMAN
NC score	0.044343 (rank : 149)	θ value	0.813845 (rank : 74)
Query Neighborhood Hits	154	Target Neighborhood Hits	186	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

VPS53_HUMAN
NC score	0.043576 (rank : 150)	θ value	2.36792 (rank : 95)
Query Neighborhood Hits	154	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VIR6, Q8WYW3, Q9BRR2, Q9BY02, Q9NV25	Gene names	VPS53
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 53.

TARSH_HUMAN
NC score	0.043545 (rank : 151)	θ value	6.88961 (rank : 142)
Query Neighborhood Hits	154	Target Neighborhood Hits	768	Shared Neighborhood Hits	37
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

VPS53_MOUSE
NC score	0.042895 (rank : 152)	θ value	2.36792 (rank : 96)
Query Neighborhood Hits	154	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CCB4, Q8C7U0, Q8CIA1, Q9CX82, Q9D6T7	Gene names	Vps53
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 53.

PCLO_HUMAN
NC score	0.041790 (rank : 153)	θ value	6.88961 (rank : 138)
Query Neighborhood Hits	154	Target Neighborhood Hits	2046	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RGS3_MOUSE
NC score	0.041787 (rank : 154)	θ value	0.365318 (rank : 63)
Query Neighborhood Hits	154	Target Neighborhood Hits	1621	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

INADL_MOUSE
NC score	0.041775 (rank : 155)	θ value	8.99809 (rank : 147)
Query Neighborhood Hits	154	Target Neighborhood Hits	290	Shared Neighborhood Hits	18
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

REXO1_MOUSE
NC score	0.041431 (rank : 156)	θ value	1.81305 (rank : 89)
Query Neighborhood Hits	154	Target Neighborhood Hits	166	Shared Neighborhood Hits	13
SwissProt Accessions	Q7TT28, Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29	Gene names	Rexo1, Kiaa1138, Tceb3bp1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1).

SFR14_MOUSE
NC score	0.041039 (rank : 157)	θ value	0.47712 (rank : 67)
Query Neighborhood Hits	154	Target Neighborhood Hits	238	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CH09, Q6PG19, Q80UY8, Q8BY32, Q8CFM0	Gene names	Sfrs14
Domain Architecture	No domain graphic available
Description	Putative splicing factor, arginine/serine-rich 14 (Arginine/serine- rich-splicing factor 14).

RASA2_HUMAN
NC score	0.040883 (rank : 158)	θ value	8.99809 (rank : 150)
Query Neighborhood Hits	154	Target Neighborhood Hits	157	Shared Neighborhood Hits	29
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

NOS1_HUMAN
NC score	0.039328 (rank : 159)	θ value	0.0563607 (rank : 40)
Query Neighborhood Hits	154	Target Neighborhood Hits	218	Shared Neighborhood Hits	11
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

GTSE1_MOUSE
NC score	0.038573 (rank : 160)	θ value	3.0926 (rank : 103)
Query Neighborhood Hits	154	Target Neighborhood Hits	245	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

NRX2A_HUMAN
NC score	0.038392 (rank : 161)	θ value	0.21417 (rank : 50)
Query Neighborhood Hits	154	Target Neighborhood Hits	614	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

CSPG5_MOUSE
NC score	0.037958 (rank : 162)	θ value	1.06291 (rank : 77)
Query Neighborhood Hits	154	Target Neighborhood Hits	211	Shared Neighborhood Hits	5
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

FMN2_HUMAN
NC score	0.036721 (rank : 163)	θ value	3.0926 (rank : 102)
Query Neighborhood Hits	154	Target Neighborhood Hits	484	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

NFH_MOUSE
NC score	0.035601 (rank : 164)	θ value	0.365318 (rank : 61)
Query Neighborhood Hits	154	Target Neighborhood Hits	2247	Shared Neighborhood Hits	56
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

AP180_HUMAN
NC score	0.035082 (rank : 165)	θ value	3.0926 (rank : 98)
Query Neighborhood Hits	154	Target Neighborhood Hits	183	Shared Neighborhood Hits	16
SwissProt Accessions	O60641, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7	Gene names	SNAP91, KIAA0656
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein).

SMOO_HUMAN
NC score	0.032435 (rank : 166)	θ value	6.88961 (rank : 141)
Query Neighborhood Hits	154	Target Neighborhood Hits	391	Shared Neighborhood Hits	28
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

TINF2_MOUSE
NC score	0.031865 (rank : 167)	θ value	3.0926 (rank : 110)
Query Neighborhood Hits	154	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXG9	Gene names	Tinf2, Tin2
Domain Architecture	No domain graphic available
Description	TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2).

AP180_MOUSE
NC score	0.031351 (rank : 168)	θ value	6.88961 (rank : 127)
Query Neighborhood Hits	154	Target Neighborhood Hits	194	Shared Neighborhood Hits	15
SwissProt Accessions	Q61548, Q61547	Gene names	Snap91
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein) (Phosphoprotein F1- 20).

XRCC4_MOUSE
NC score	0.031348 (rank : 169)	θ value	2.36792 (rank : 97)
Query Neighborhood Hits	154	Target Neighborhood Hits	104	Shared Neighborhood Hits	2
SwissProt Accessions	Q924T3, Q8BKC9, Q8BU02, Q9D6U6	Gene names	Xrcc4
Domain Architecture
Description	DNA-repair protein XRCC4 (X-ray repair cross-complementing protein 4).

FA62A_MOUSE
NC score	0.029070 (rank : 170)	θ value	0.62314 (rank : 69)
Query Neighborhood Hits	154	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FLNB_MOUSE
NC score	0.028730 (rank : 171)	θ value	0.813845 (rank : 73)
Query Neighborhood Hits	154	Target Neighborhood Hits	126	Shared Neighborhood Hits	7
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

MLL3_HUMAN
NC score	0.027487 (rank : 172)	θ value	1.81305 (rank : 88)
Query Neighborhood Hits	154	Target Neighborhood Hits	1644	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

STC2_HUMAN
NC score	0.027384 (rank : 173)	θ value	3.0926 (rank : 109)
Query Neighborhood Hits	154	Target Neighborhood Hits	70	Shared Neighborhood Hits	4
SwissProt Accessions	O76061	Gene names	STC2
Domain Architecture
Description	Stanniocalcin-2 precursor (STC-2) (Stanniocalcin-related protein) (STCRP) (STC-related protein).

MAML2_HUMAN
NC score	0.027117 (rank : 174)	θ value	6.88961 (rank : 135)
Query Neighborhood Hits	154	Target Neighborhood Hits	360	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IZL2, Q6AI23, Q6Y3A3, Q8IUL3, Q96JK6	Gene names	MAML2, KIAA1819
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 2 (Mam-2).

FLNB_HUMAN
NC score	0.026792 (rank : 175)	θ value	2.36792 (rank : 91)
Query Neighborhood Hits	154	Target Neighborhood Hits	111	Shared Neighborhood Hits	8
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

TTF2_MOUSE
NC score	0.026444 (rank : 176)	θ value	0.62314 (rank : 71)
Query Neighborhood Hits	154	Target Neighborhood Hits	364	Shared Neighborhood Hits	10
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

FMN2_MOUSE
NC score	0.026395 (rank : 177)	θ value	8.99809 (rank : 146)
Query Neighborhood Hits	154	Target Neighborhood Hits	349	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

EPN3_HUMAN
NC score	0.026278 (rank : 178)	θ value	1.38821 (rank : 83)
Query Neighborhood Hits	154	Target Neighborhood Hits	197	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H201, Q9BVN6, Q9NWK2	Gene names	EPN3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

FANCE_HUMAN
NC score	0.025181 (rank : 179)	θ value	6.88961 (rank : 132)
Query Neighborhood Hits	154	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HB96, Q4ZGH2	Gene names	FANCE
Domain Architecture	No domain graphic available
Description	Fanconi anemia group E protein (Protein FACE).

MTSS1_MOUSE
NC score	0.025137 (rank : 180)	θ value	6.88961 (rank : 137)
Query Neighborhood Hits	154	Target Neighborhood Hits	592	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

PCNT_MOUSE
NC score	0.025031 (rank : 181)	θ value	3.0926 (rank : 106)
Query Neighborhood Hits	154	Target Neighborhood Hits	1207	Shared Neighborhood Hits	22
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

MYO15_HUMAN
NC score	0.024251 (rank : 182)	θ value	4.03905 (rank : 114)
Query Neighborhood Hits	154	Target Neighborhood Hits	671	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

HSF1_MOUSE
NC score	0.023591 (rank : 183)	θ value	3.0926 (rank : 104)
Query Neighborhood Hits	154	Target Neighborhood Hits	267	Shared Neighborhood Hits	13
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

MBD5_HUMAN
NC score	0.023307 (rank : 184)	θ value	6.88961 (rank : 136)
Query Neighborhood Hits	154	Target Neighborhood Hits	176	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

PCY1B_MOUSE
NC score	0.022993 (rank : 185)	θ value	5.27518 (rank : 124)
Query Neighborhood Hits	154	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	Q811Q9, Q3UEW0, Q80Y63, Q811Q8, Q8BKD2, Q8C085	Gene names	Pcyt1b
Domain Architecture	No domain graphic available
Description	Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (Phosphorylcholine transferase B) (CTP:phosphocholine cytidylyltransferase B) (CT B) (CCT B) (CCT-beta).

PCY1B_HUMAN
NC score	0.022829 (rank : 186)	θ value	5.27518 (rank : 123)
Query Neighborhood Hits	154	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y5K3, O60621, Q86XC9	Gene names	PCYT1B, CCTB
Domain Architecture
Description	Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (Phosphorylcholine transferase B) (CTP:phosphocholine cytidylyltransferase B) (CT B) (CCT B) (CCT-beta).

ZN385_HUMAN
NC score	0.022591 (rank : 187)	θ value	8.99809 (rank : 153)
Query Neighborhood Hits	154	Target Neighborhood Hits	614	Shared Neighborhood Hits	22
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

RFIP5_MOUSE
NC score	0.022525 (rank : 188)	θ value	4.03905 (rank : 117)
Query Neighborhood Hits	154	Target Neighborhood Hits	126	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

MY18A_MOUSE
NC score	0.022281 (rank : 189)	θ value	2.36792 (rank : 92)
Query Neighborhood Hits	154	Target Neighborhood Hits	1989	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

SYNE1_HUMAN
NC score	0.021805 (rank : 190)	θ value	5.27518 (rank : 126)
Query Neighborhood Hits	154	Target Neighborhood Hits	1484	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

ZO3_MOUSE
NC score	0.020747 (rank : 191)	θ value	8.99809 (rank : 154)
Query Neighborhood Hits	154	Target Neighborhood Hits	224	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

LR37A_HUMAN
NC score	0.020191 (rank : 192)	θ value	6.88961 (rank : 134)
Query Neighborhood Hits	154	Target Neighborhood Hits	720	Shared Neighborhood Hits	27
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

TMM26_MOUSE
NC score	0.020180 (rank : 193)	θ value	6.88961 (rank : 143)
Query Neighborhood Hits	154	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q3UP23, Q8BN94	Gene names	Tmem26
Domain Architecture	No domain graphic available
Description	Transmembrane protein 26.

CO8B_MOUSE
NC score	0.018067 (rank : 194)	θ value	1.38821 (rank : 82)
Query Neighborhood Hits	154	Target Neighborhood Hits	224	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

FMO4_MOUSE
NC score	0.017652 (rank : 195)	θ value	1.38821 (rank : 85)
Query Neighborhood Hits	154	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VHG0	Gene names	Fmo4
Domain Architecture	No domain graphic available
Description	Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC 1.14.13.8) (Hepatic flavin-containing monooxygenase 4) (FMO 4) (Dimethylaniline oxidase 4).

RECQ5_HUMAN
NC score	0.017180 (rank : 196)	θ value	5.27518 (rank : 125)
Query Neighborhood Hits	154	Target Neighborhood Hits	390	Shared Neighborhood Hits	15
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

ORC1_MOUSE
NC score	0.016015 (rank : 197)	θ value	8.99809 (rank : 149)
Query Neighborhood Hits	154	Target Neighborhood Hits	65	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z1N2	Gene names	Orc1l, Orc1
Domain Architecture
Description	Origin recognition complex subunit 1.

SMC4_HUMAN
NC score	0.015486 (rank : 198)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	154	Target Neighborhood Hits	937	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

EVPL_MOUSE
NC score	0.014963 (rank : 199)	θ value	5.27518 (rank : 119)
Query Neighborhood Hits	154	Target Neighborhood Hits	952	Shared Neighborhood Hits	19
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

MACF1_HUMAN
NC score	0.014482 (rank : 200)	θ value	5.27518 (rank : 121)
Query Neighborhood Hits	154	Target Neighborhood Hits	1341	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

RIMB2_HUMAN
NC score	0.014066 (rank : 201)	θ value	6.88961 (rank : 139)
Query Neighborhood Hits	154	Target Neighborhood Hits	263	Shared Neighborhood Hits	10
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SNX15_MOUSE
NC score	0.013224 (rank : 202)	θ value	8.99809 (rank : 152)
Query Neighborhood Hits	154	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WE1	Gene names	Snx15
Domain Architecture	No domain graphic available
Description	Sorting nexin-15.

CBL_MOUSE
NC score	0.013041 (rank : 203)	θ value	6.88961 (rank : 129)
Query Neighborhood Hits	154	Target Neighborhood Hits	426	Shared Neighborhood Hits	15
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

ASTL_HUMAN
NC score	0.012744 (rank : 204)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	154	Target Neighborhood Hits	252	Shared Neighborhood Hits	13
SwissProt Accessions	Q6HA08	Gene names	ASTL
Domain Architecture	No domain graphic available
Description	Astacin-like metalloendopeptidase precursor (EC 3.4.-.-) (Oocyte astacin) (Ovastacin).

PEX6_MOUSE
NC score	0.011332 (rank : 205)	θ value	2.36792 (rank : 93)
Query Neighborhood Hits	154	Target Neighborhood Hits	94	Shared Neighborhood Hits	2
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

KCNN3_HUMAN
NC score	0.010590 (rank : 206)	θ value	6.88961 (rank : 133)
Query Neighborhood Hits	154	Target Neighborhood Hits	216	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UGI6, O43517	Gene names	KCNN3, K3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa3).

GP152_MOUSE
NC score	0.010430 (rank : 207)	θ value	4.03905 (rank : 113)
Query Neighborhood Hits	154	Target Neighborhood Hits	607	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

AMOL1_MOUSE
NC score	0.009559 (rank : 208)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	154	Target Neighborhood Hits	445	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D4H4, Q571F1	Gene names	Amotl1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

ACK1_HUMAN
NC score	0.008430 (rank : 209)	θ value	1.38821 (rank : 81)
Query Neighborhood Hits	154	Target Neighborhood Hits	1140	Shared Neighborhood Hits	29
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

LRC27_MOUSE
NC score	0.007674 (rank : 210)	θ value	8.99809 (rank : 148)
Query Neighborhood Hits	154	Target Neighborhood Hits	290	Shared Neighborhood Hits	6
SwissProt Accessions	Q80YS5, Q9D6Z2	Gene names	Lrrc27
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 27.

OTP_MOUSE
NC score	0.004823 (rank : 211)	θ value	4.03905 (rank : 115)
Query Neighborhood Hits	154	Target Neighborhood Hits	387	Shared Neighborhood Hits	5
SwissProt Accessions	O09113	Gene names	Otp
Domain Architecture
Description	Homeobox protein orthopedia.

LIMK2_HUMAN
NC score	0.004558 (rank : 212)	θ value	0.365318 (rank : 60)
Query Neighborhood Hits	154	Target Neighborhood Hits	986	Shared Neighborhood Hits	12
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

EPHAA_HUMAN
NC score	0.004012 (rank : 213)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	154	Target Neighborhood Hits	960	Shared Neighborhood Hits	11
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHA8_MOUSE
NC score	0.002186 (rank : 214)	θ value	6.88961 (rank : 131)
Query Neighborhood Hits	154	Target Neighborhood Hits	969	Shared Neighborhood Hits	10
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

PRD14_HUMAN
NC score	0.001831 (rank : 215)	θ value	0.279714 (rank : 57)
Query Neighborhood Hits	154	Target Neighborhood Hits	757	Shared Neighborhood Hits	3
SwissProt Accessions	Q9GZV8, Q86UX9	Gene names	PRDM14
Domain Architecture
Description	PR domain zinc finger protein 14 (PR domain-containing protein 14).

RLF_HUMAN
NC score	-0.000246 (rank : 216)	θ value	8.99809 (rank : 151)
Query Neighborhood Hits	154	Target Neighborhood Hits	775	Shared Neighborhood Hits	4
SwissProt Accessions	Q13129, Q9NU60	Gene names	RLF
Domain Architecture	No domain graphic available
Description	Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15- related protein).