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Network neighborhood for query Sequence : BIG2_HUMAN

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BIG2_HUMAN
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

BIG1_HUMAN
θ value	0 (rank : 1)	NC score	0.992959 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	76	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BIG2_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

GBF1_HUMAN
θ value	4.10295e-61 (rank : 3)	NC score	0.868836 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

CYH1_MOUSE
θ value	1.23823e-49 (rank : 4)	NC score	0.819373 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	176	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH1_HUMAN
θ value	1.61718e-49 (rank : 5)	NC score	0.817051 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	184	Shared Neighborhood Hits	24
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH3_HUMAN
θ value	3.37202e-47 (rank : 6)	NC score	0.820080 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	137	Shared Neighborhood Hits	24
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH3_MOUSE
θ value	5.7518e-47 (rank : 7)	NC score	0.814099 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	148	Shared Neighborhood Hits	24
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH2_HUMAN
θ value	9.18288e-45 (rank : 8)	NC score	0.819934 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	175	Shared Neighborhood Hits	23
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	1.56636e-44 (rank : 9)	NC score	0.819922 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	171	Shared Neighborhood Hits	23
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH4_MOUSE
θ value	3.48949e-44 (rank : 10)	NC score	0.819422 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	134	Shared Neighborhood Hits	23
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH4_HUMAN
θ value	6.58091e-43 (rank : 11)	NC score	0.818462 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	135	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

IQEC1_MOUSE
θ value	4.00176e-32 (rank : 12)	NC score	0.801806 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	54	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

IQEC1_HUMAN
θ value	5.22648e-32 (rank : 13)	NC score	0.799381 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	76	Shared Neighborhood Hits	22
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC3_HUMAN
θ value	4.42448e-31 (rank : 14)	NC score	0.805995 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC3_MOUSE
θ value	4.42448e-31 (rank : 15)	NC score	0.797991 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	274	Shared Neighborhood Hits	26
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC2_MOUSE
θ value	1.28732e-30 (rank : 16)	NC score	0.755825 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	417	Shared Neighborhood Hits	23
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_HUMAN
θ value	1.6813e-30 (rank : 17)	NC score	0.755913 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	403	Shared Neighborhood Hits	23
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

PSD4_HUMAN
θ value	1.63225e-17 (rank : 18)	NC score	0.687635 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	178	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

PSD3_HUMAN
θ value	6.85773e-16 (rank : 19)	NC score	0.726307 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	75	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

FBX8_MOUSE
θ value	1.16975e-15 (rank : 20)	NC score	0.758627 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	45	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FBX8_HUMAN
θ value	1.99529e-15 (rank : 21)	NC score	0.756173 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	44	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

PSD4_MOUSE
θ value	2.60593e-15 (rank : 22)	NC score	0.691203 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	78	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

TGON2_MOUSE
θ value	0.279714 (rank : 23)	NC score	0.029284 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	277	Shared Neighborhood Hits	5
SwissProt Accessions	Q62314	Gene names	Tgoln2, Ttgn2
Domain Architecture	No domain graphic available
Description	Trans-Golgi network integral membrane protein 2 precursor (TGN38B).

SMC3_HUMAN
θ value	0.365318 (rank : 24)	NC score	0.018752 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	1186	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	0.365318 (rank : 25)	NC score	0.018824 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	1187	Shared Neighborhood Hits	16
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

PEX14_MOUSE
θ value	0.62314 (rank : 26)	NC score	0.032533 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R0A0	Gene names	Pex14
Domain Architecture
Description	Peroxisomal membrane protein PEX14 (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) (PTS1 receptor docking protein).

CI039_HUMAN
θ value	1.38821 (rank : 27)	NC score	0.009922 (rank : 80)
Query Neighborhood Hits	66	Target Neighborhood Hits	1171	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

MNDA_HUMAN
θ value	1.81305 (rank : 28)	NC score	0.015295 (rank : 69)
Query Neighborhood Hits	66	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	P41218	Gene names	MNDA
Domain Architecture
Description	Myeloid cell nuclear differentiation antigen.

RFWD2_HUMAN
θ value	1.81305 (rank : 29)	NC score	0.011872 (rank : 75)
Query Neighborhood Hits	66	Target Neighborhood Hits	518	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

DYNA_HUMAN
θ value	2.36792 (rank : 30)	NC score	0.011589 (rank : 76)
Query Neighborhood Hits	66	Target Neighborhood Hits	1194	Shared Neighborhood Hits	14
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

MINK1_MOUSE
θ value	2.36792 (rank : 31)	NC score	0.000568 (rank : 101)
Query Neighborhood Hits	66	Target Neighborhood Hits	1451	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

RFWD2_MOUSE
θ value	2.36792 (rank : 32)	NC score	0.011309 (rank : 77)
Query Neighborhood Hits	66	Target Neighborhood Hits	535	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

CENPE_HUMAN
θ value	3.0926 (rank : 33)	NC score	0.004140 (rank : 97)
Query Neighborhood Hits	66	Target Neighborhood Hits	2060	Shared Neighborhood Hits	20
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

GP73_MOUSE
θ value	3.0926 (rank : 34)	NC score	0.013543 (rank : 71)
Query Neighborhood Hits	66	Target Neighborhood Hits	506	Shared Neighborhood Hits	11
SwissProt Accessions	Q91XA2	Gene names	Golph2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

ADAM2_MOUSE
θ value	4.03905 (rank : 35)	NC score	0.003598 (rank : 98)
Query Neighborhood Hits	66	Target Neighborhood Hits	209	Shared Neighborhood Hits	2
SwissProt Accessions	Q60718, Q60814, Q9D4G3, Q9QWJ0	Gene names	Adam2, Ftnb
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta).

ANR47_MOUSE
θ value	4.03905 (rank : 36)	NC score	0.004705 (rank : 93)
Query Neighborhood Hits	66	Target Neighborhood Hits	350	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ATRX_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.008923 (rank : 82)
Query Neighborhood Hits	66	Target Neighborhood Hits	842	Shared Neighborhood Hits	13
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

CHD9_HUMAN
θ value	4.03905 (rank : 38)	NC score	0.008543 (rank : 84)
Query Neighborhood Hits	66	Target Neighborhood Hits	343	Shared Neighborhood Hits	8
SwissProt Accessions	Q3L8U1, O15025, Q1WF12, Q6DTK9, Q9H9V7	Gene names	CHD9, KIAA0308, KISH2, PRIC320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin remodeling factor CHROM1) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha-interacting complex protein 320 kDa) (Kismet homolog 2).

CHD9_MOUSE
θ value	4.03905 (rank : 39)	NC score	0.008255 (rank : 86)
Query Neighborhood Hits	66	Target Neighborhood Hits	427	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

SEPT9_HUMAN
θ value	4.03905 (rank : 40)	NC score	0.009707 (rank : 81)
Query Neighborhood Hits	66	Target Neighborhood Hits	706	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

CCD96_HUMAN
θ value	5.27518 (rank : 41)	NC score	0.012290 (rank : 73)
Query Neighborhood Hits	66	Target Neighborhood Hits	595	Shared Neighborhood Hits	17
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CD5R1_HUMAN
θ value	5.27518 (rank : 42)	NC score	0.016891 (rank : 67)
Query Neighborhood Hits	66	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q15078	Gene names	CDK5R1, CDK5R, NCK5A
Domain Architecture
Description	Cyclin-dependent kinase 5 activator 1 precursor (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (Tau protein kinase II 23 kDa subunit) (TPKII regulatory subunit) (p23) (p25) (p35) [Contains: Cyclin-dependent kinase 5 activator 1, p35; Cyclin- dependent kinase 5 activator 1, p25].

CD5R1_MOUSE
θ value	5.27518 (rank : 43)	NC score	0.016815 (rank : 68)
Query Neighborhood Hits	66	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P61809, Q62938	Gene names	Cdk5r1, Cdk5r, Nck5a
Domain Architecture
Description	Cyclin-dependent kinase 5 activator 1 precursor (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (Tau protein kinase II 23 kDa subunit) (TPKII regulatory subunit) (p23) (p25) (p35) [Contains: Cyclin-dependent kinase 5 activator 1, p35; Cyclin- dependent kinase 5 activator 1, p25].

DMD_MOUSE
θ value	5.27518 (rank : 44)	NC score	0.005160 (rank : 90)
Query Neighborhood Hits	66	Target Neighborhood Hits	1111	Shared Neighborhood Hits	15
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

RASA3_MOUSE
θ value	5.27518 (rank : 45)	NC score	0.036135 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	144	Shared Neighborhood Hits	10
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

ARHGA_HUMAN
θ value	6.88961 (rank : 46)	NC score	0.008749 (rank : 83)
Query Neighborhood Hits	66	Target Neighborhood Hits	187	Shared Neighborhood Hits	5
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

DYNA_MOUSE
θ value	6.88961 (rank : 47)	NC score	0.008298 (rank : 85)
Query Neighborhood Hits	66	Target Neighborhood Hits	1084	Shared Neighborhood Hits	15
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

E2F1_MOUSE
θ value	6.88961 (rank : 48)	NC score	0.012714 (rank : 72)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q61501, Q80VZ3	Gene names	E2f1
Domain Architecture
Description	Transcription factor E2F1 (E2F-1).

HS74L_MOUSE
θ value	6.88961 (rank : 49)	NC score	0.004182 (rank : 96)
Query Neighborhood Hits	66	Target Neighborhood Hits	141	Shared Neighborhood Hits	6
SwissProt Accessions	P48722, P97854, Q8BQD0, Q8CC45, Q91X29	Gene names	Hspa4l, Apg1, Hsp4l, Osp94
Domain Architecture
Description	Heat shock 70 kDa protein 4L (Osmotic stress protein 94) (Heat shock 70-related protein APG-1).

IFT81_MOUSE
θ value	6.88961 (rank : 50)	NC score	0.007330 (rank : 87)
Query Neighborhood Hits	66	Target Neighborhood Hits	959	Shared Neighborhood Hits	19
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

LGR6_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.001411 (rank : 100)
Query Neighborhood Hits	66	Target Neighborhood Hits	344	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBX8, Q5T509, Q5T512, Q6UY15, Q86VU0, Q96K69, Q9BYD7	Gene names	LGR6
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 6 (VTS20631).

NOCT_MOUSE
θ value	6.88961 (rank : 52)	NC score	0.010804 (rank : 79)
Query Neighborhood Hits	66	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	O35710, Q9QZG9	Gene names	Ccrn4l, Ccr4, Noc
Domain Architecture
Description	Nocturnin (CCR4 protein homolog).

TCF8_HUMAN
θ value	6.88961 (rank : 53)	NC score	-0.001580 (rank : 104)
Query Neighborhood Hits	66	Target Neighborhood Hits	1057	Shared Neighborhood Hits	10
SwissProt Accessions	P37275, Q12924, Q13800	Gene names	TCF8, AREB6
Domain Architecture
Description	Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2).

ZFX_HUMAN
θ value	6.88961 (rank : 54)	NC score	-0.001455 (rank : 103)
Query Neighborhood Hits	66	Target Neighborhood Hits	751	Shared Neighborhood Hits	5
SwissProt Accessions	P17010, O43668, Q8WYJ8	Gene names	ZFX
Domain Architecture
Description	Zinc finger X-chromosomal protein.

ZFX_MOUSE
θ value	6.88961 (rank : 55)	NC score	-0.001448 (rank : 102)
Query Neighborhood Hits	66	Target Neighborhood Hits	748	Shared Neighborhood Hits	5
SwissProt Accessions	P17012, P17011	Gene names	Zfx
Domain Architecture
Description	Zinc finger X-chromosomal protein.

CC062_HUMAN
θ value	8.99809 (rank : 56)	NC score	0.011000 (rank : 78)
Query Neighborhood Hits	66	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZUJ4, Q6P7E9, Q7Z3X6	Gene names	C3orf62
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf62.

DDX11_MOUSE
θ value	8.99809 (rank : 57)	NC score	0.006770 (rank : 88)
Query Neighborhood Hits	66	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q6AXC6	Gene names	Ddx11
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-) (DEAD/H box protein 11).

ENOA_HUMAN
θ value	8.99809 (rank : 58)	NC score	0.004924 (rank : 92)
Query Neighborhood Hits	66	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P06733, P22712, Q16704, Q4TUS4, Q658M5, Q6GMP2, Q71V37, Q7Z3V6, Q8WU71, Q9UM55	Gene names	ENO1, ENO1L1, MBPB1, MPB1
Domain Architecture
Description	Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Non- neural enolase) (NNE) (Enolase 1) (Phosphopyruvate hydratase) (C-myc promoter-binding protein) (MBP-1) (MPB-1) (Plasminogen-binding protein).

GEMI4_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.011873 (rank : 74)
Query Neighborhood Hits	66	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P57678, Q9NZS7, Q9UG32, Q9Y4Q2	Gene names	GEMIN4
Domain Architecture	No domain graphic available
Description	Component of gems 4 (Gemin-4) (p97).

NDUB7_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.013599 (rank : 70)
Query Neighborhood Hits	66	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P17568, Q9UI16	Gene names	NDUFB7
Domain Architecture
Description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase B18 subunit) (Complex I-B18) (CI-B18) (Cell adhesion protein SQM1).

REST_MOUSE
θ value	8.99809 (rank : 61)	NC score	0.004704 (rank : 94)
Query Neighborhood Hits	66	Target Neighborhood Hits	1506	Shared Neighborhood Hits	21
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

RYR1_HUMAN
θ value	8.99809 (rank : 62)	NC score	0.005227 (rank : 89)
Query Neighborhood Hits	66	Target Neighborhood Hits	303	Shared Neighborhood Hits	7
SwissProt Accessions	P21817, Q16314, Q16368, Q9NPK1, Q9P1U4	Gene names	RYR1, RYDR
Domain Architecture
Description	Ryanodine receptor 1 (Skeletal muscle-type ryanodine receptor) (RyR1) (RYR-1) (Skeletal muscle calcium release channel).

SRBS1_MOUSE
θ value	8.99809 (rank : 63)	NC score	0.003277 (rank : 99)
Query Neighborhood Hits	66	Target Neighborhood Hits	409	Shared Neighborhood Hits	2
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

UTRO_HUMAN
θ value	8.99809 (rank : 64)	NC score	0.005144 (rank : 91)
Query Neighborhood Hits	66	Target Neighborhood Hits	960	Shared Neighborhood Hits	14
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

WRN_MOUSE
θ value	8.99809 (rank : 65)	NC score	0.004474 (rank : 95)
Query Neighborhood Hits	66	Target Neighborhood Hits	295	Shared Neighborhood Hits	6
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

ZFA_MOUSE
θ value	8.99809 (rank : 66)	NC score	-0.001610 (rank : 105)
Query Neighborhood Hits	66	Target Neighborhood Hits	746	Shared Neighborhood Hits	5
SwissProt Accessions	P23607	Gene names	Zfa
Domain Architecture
Description	Zinc finger autosomal protein.

3BP2_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.107587 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	296	Shared Neighborhood Hits	8
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.111468 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	142	Shared Neighborhood Hits	8
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ANLN_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.114396 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	222	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

ANLN_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.095331 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	297	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

CENB2_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.065749 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	425	Shared Neighborhood Hits	13
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.060713 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	395	Shared Neighborhood Hits	12
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CNKR1_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.184954 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	154	Shared Neighborhood Hits	11
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.096834 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	197	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.096743 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	197	Shared Neighborhood Hits	9
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

DAPP1_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.109990 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	227	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.115678 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	225	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DYN2_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.052593 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	112	Shared Neighborhood Hits	8
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.052557 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	104	Shared Neighborhood Hits	8
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

DYN3_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.053145 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	158	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

GNRP_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.056023 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	239	Shared Neighborhood Hits	11
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.053405 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	191	Shared Neighborhood Hits	9
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

MTMR5_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.053391 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	141	Shared Neighborhood Hits	8
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

PKHA1_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.133092 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	127	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.132628 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	120	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.103277 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	119	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.117065 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	116	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA4_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.110635 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	283	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.120365 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	202	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.093286 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	455	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.130094 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	556	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.124825 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	591	Shared Neighborhood Hits	18
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHB1_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.051305 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB2_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.055970 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	54	Shared Neighborhood Hits	8
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHB2_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.054844 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PLEK2_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.099170 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	101	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.100852 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.128758 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.132013 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

RASA1_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.079703 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	258	Shared Neighborhood Hits	9
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RHG25_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.074191 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	550	Shared Neighborhood Hits	20
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.077105 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	492	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SWP70_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.070219 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	973	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.061378 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	1097	Shared Neighborhood Hits	26
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TBCD2_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.051135 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	419	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

Hits sorted by NC score

BIG2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

BIG1_HUMAN
NC score	0.992959 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	76	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

GBF1_HUMAN
NC score	0.868836 (rank : 3)	θ value	4.10295e-61 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

CYH3_HUMAN
NC score	0.820080 (rank : 4)	θ value	3.37202e-47 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	137	Shared Neighborhood Hits	24
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH2_HUMAN
NC score	0.819934 (rank : 5)	θ value	9.18288e-45 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	175	Shared Neighborhood Hits	23
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.819922 (rank : 6)	θ value	1.56636e-44 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	171	Shared Neighborhood Hits	23
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH4_MOUSE
NC score	0.819422 (rank : 7)	θ value	3.48949e-44 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	134	Shared Neighborhood Hits	23
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH1_MOUSE
NC score	0.819373 (rank : 8)	θ value	1.23823e-49 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	176	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH4_HUMAN
NC score	0.818462 (rank : 9)	θ value	6.58091e-43 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	135	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH1_HUMAN
NC score	0.817051 (rank : 10)	θ value	1.61718e-49 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	184	Shared Neighborhood Hits	24
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH3_MOUSE
NC score	0.814099 (rank : 11)	θ value	5.7518e-47 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	148	Shared Neighborhood Hits	24
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

IQEC3_HUMAN
NC score	0.805995 (rank : 12)	θ value	4.42448e-31 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC1_MOUSE
NC score	0.801806 (rank : 13)	θ value	4.00176e-32 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	54	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

IQEC1_HUMAN
NC score	0.799381 (rank : 14)	θ value	5.22648e-32 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	76	Shared Neighborhood Hits	22
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC3_MOUSE
NC score	0.797991 (rank : 15)	θ value	4.42448e-31 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	274	Shared Neighborhood Hits	26
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

FBX8_MOUSE
NC score	0.758627 (rank : 16)	θ value	1.16975e-15 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	45	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FBX8_HUMAN
NC score	0.756173 (rank : 17)	θ value	1.99529e-15 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	44	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

IQEC2_HUMAN
NC score	0.755913 (rank : 18)	θ value	1.6813e-30 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	403	Shared Neighborhood Hits	23
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_MOUSE
NC score	0.755825 (rank : 19)	θ value	1.28732e-30 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	417	Shared Neighborhood Hits	23
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

PSD3_HUMAN
NC score	0.726307 (rank : 20)	θ value	6.85773e-16 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	75	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_MOUSE
NC score	0.691203 (rank : 21)	θ value	2.60593e-15 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	78	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

PSD4_HUMAN
NC score	0.687635 (rank : 22)	θ value	1.63225e-17 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	178	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

CNKR1_HUMAN
NC score	0.184954 (rank : 23)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	66	Target Neighborhood Hits	154	Shared Neighborhood Hits	11
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

PKHA1_HUMAN
NC score	0.133092 (rank : 24)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	66	Target Neighborhood Hits	127	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.132628 (rank : 25)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	66	Target Neighborhood Hits	120	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PLEK_MOUSE
NC score	0.132013 (rank : 26)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	66	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PKHA6_HUMAN
NC score	0.130094 (rank : 27)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	66	Target Neighborhood Hits	556	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PLEK_HUMAN
NC score	0.128758 (rank : 28)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	66	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PKHA6_MOUSE
NC score	0.124825 (rank : 29)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	66	Target Neighborhood Hits	591	Shared Neighborhood Hits	18
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA4_MOUSE
NC score	0.120365 (rank : 30)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	66	Target Neighborhood Hits	202	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA2_MOUSE
NC score	0.117065 (rank : 31)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	66	Target Neighborhood Hits	116	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

DAPP1_MOUSE
NC score	0.115678 (rank : 32)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	66	Target Neighborhood Hits	225	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ANLN_HUMAN
NC score	0.114396 (rank : 33)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	66	Target Neighborhood Hits	222	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

3BP2_MOUSE
NC score	0.111468 (rank : 34)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	66	Target Neighborhood Hits	142	Shared Neighborhood Hits	8
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PKHA4_HUMAN
NC score	0.110635 (rank : 35)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	66	Target Neighborhood Hits	283	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

DAPP1_HUMAN
NC score	0.109990 (rank : 36)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	66	Target Neighborhood Hits	227	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

3BP2_HUMAN
NC score	0.107587 (rank : 37)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	66	Target Neighborhood Hits	296	Shared Neighborhood Hits	8
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PKHA2_HUMAN
NC score	0.103277 (rank : 38)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	66	Target Neighborhood Hits	119	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PLEK2_MOUSE
NC score	0.100852 (rank : 39)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	66	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_HUMAN
NC score	0.099170 (rank : 40)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	66	Target Neighborhood Hits	101	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

CNKR2_HUMAN
NC score	0.096834 (rank : 41)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	66	Target Neighborhood Hits	197	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
NC score	0.096743 (rank : 42)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	66	Target Neighborhood Hits	197	Shared Neighborhood Hits	9
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ANLN_MOUSE
NC score	0.095331 (rank : 43)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	66	Target Neighborhood Hits	297	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

PKHA5_HUMAN
NC score	0.093286 (rank : 44)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	66	Target Neighborhood Hits	455	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RASA1_HUMAN
NC score	0.079703 (rank : 45)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	66	Target Neighborhood Hits	258	Shared Neighborhood Hits	9
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RHG25_MOUSE
NC score	0.077105 (rank : 46)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	66	Target Neighborhood Hits	492	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_HUMAN
NC score	0.074191 (rank : 47)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	66	Target Neighborhood Hits	550	Shared Neighborhood Hits	20
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SWP70_HUMAN
NC score	0.070219 (rank : 48)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	66	Target Neighborhood Hits	973	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CENB2_HUMAN
NC score	0.065749 (rank : 49)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	66	Target Neighborhood Hits	425	Shared Neighborhood Hits	13
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

SWP70_MOUSE
NC score	0.061378 (rank : 50)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	66	Target Neighborhood Hits	1097	Shared Neighborhood Hits	26
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CENB5_HUMAN
NC score	0.060713 (rank : 51)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	66	Target Neighborhood Hits	395	Shared Neighborhood Hits	12
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

GNRP_HUMAN
NC score	0.056023 (rank : 52)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	66	Target Neighborhood Hits	239	Shared Neighborhood Hits	11
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

PKHB2_HUMAN
NC score	0.055970 (rank : 53)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	66	Target Neighborhood Hits	54	Shared Neighborhood Hits	8
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHB2_MOUSE
NC score	0.054844 (rank : 54)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	66	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

GNRP_MOUSE
NC score	0.053405 (rank : 55)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	66	Target Neighborhood Hits	191	Shared Neighborhood Hits	9
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

MTMR5_HUMAN
NC score	0.053391 (rank : 56)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	66	Target Neighborhood Hits	141	Shared Neighborhood Hits	8
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

DYN3_HUMAN
NC score	0.053145 (rank : 57)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	66	Target Neighborhood Hits	158	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

DYN2_HUMAN
NC score	0.052593 (rank : 58)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	66	Target Neighborhood Hits	112	Shared Neighborhood Hits	8
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
NC score	0.052557 (rank : 59)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	66	Target Neighborhood Hits	104	Shared Neighborhood Hits	8
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

PKHB1_HUMAN
NC score	0.051305 (rank : 60)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	66	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

TBCD2_HUMAN
NC score	0.051135 (rank : 61)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	66	Target Neighborhood Hits	419	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

RASA3_MOUSE
NC score	0.036135 (rank : 62)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	144	Shared Neighborhood Hits	10
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

PEX14_MOUSE
NC score	0.032533 (rank : 63)	θ value	0.62314 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R0A0	Gene names	Pex14
Domain Architecture
Description	Peroxisomal membrane protein PEX14 (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) (PTS1 receptor docking protein).

TGON2_MOUSE
NC score	0.029284 (rank : 64)	θ value	0.279714 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	277	Shared Neighborhood Hits	5
SwissProt Accessions	Q62314	Gene names	Tgoln2, Ttgn2
Domain Architecture	No domain graphic available
Description	Trans-Golgi network integral membrane protein 2 precursor (TGN38B).

SMC3_MOUSE
NC score	0.018824 (rank : 65)	θ value	0.365318 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	1187	Shared Neighborhood Hits	16
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

SMC3_HUMAN
NC score	0.018752 (rank : 66)	θ value	0.365318 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	1186	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

CD5R1_HUMAN
NC score	0.016891 (rank : 67)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q15078	Gene names	CDK5R1, CDK5R, NCK5A
Domain Architecture
Description	Cyclin-dependent kinase 5 activator 1 precursor (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (Tau protein kinase II 23 kDa subunit) (TPKII regulatory subunit) (p23) (p25) (p35) [Contains: Cyclin-dependent kinase 5 activator 1, p35; Cyclin- dependent kinase 5 activator 1, p25].

CD5R1_MOUSE
NC score	0.016815 (rank : 68)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P61809, Q62938	Gene names	Cdk5r1, Cdk5r, Nck5a
Domain Architecture
Description	Cyclin-dependent kinase 5 activator 1 precursor (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (Tau protein kinase II 23 kDa subunit) (TPKII regulatory subunit) (p23) (p25) (p35) [Contains: Cyclin-dependent kinase 5 activator 1, p35; Cyclin- dependent kinase 5 activator 1, p25].

MNDA_HUMAN
NC score	0.015295 (rank : 69)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	P41218	Gene names	MNDA
Domain Architecture
Description	Myeloid cell nuclear differentiation antigen.

NDUB7_HUMAN
NC score	0.013599 (rank : 70)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P17568, Q9UI16	Gene names	NDUFB7
Domain Architecture
Description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase B18 subunit) (Complex I-B18) (CI-B18) (Cell adhesion protein SQM1).

GP73_MOUSE
NC score	0.013543 (rank : 71)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	506	Shared Neighborhood Hits	11
SwissProt Accessions	Q91XA2	Gene names	Golph2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

E2F1_MOUSE
NC score	0.012714 (rank : 72)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q61501, Q80VZ3	Gene names	E2f1
Domain Architecture
Description	Transcription factor E2F1 (E2F-1).

CCD96_HUMAN
NC score	0.012290 (rank : 73)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	595	Shared Neighborhood Hits	17
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

GEMI4_HUMAN
NC score	0.011873 (rank : 74)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P57678, Q9NZS7, Q9UG32, Q9Y4Q2	Gene names	GEMIN4
Domain Architecture	No domain graphic available
Description	Component of gems 4 (Gemin-4) (p97).

RFWD2_HUMAN
NC score	0.011872 (rank : 75)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	518	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

DYNA_HUMAN
NC score	0.011589 (rank : 76)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	1194	Shared Neighborhood Hits	14
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

RFWD2_MOUSE
NC score	0.011309 (rank : 77)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	535	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

CC062_HUMAN
NC score	0.011000 (rank : 78)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZUJ4, Q6P7E9, Q7Z3X6	Gene names	C3orf62
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf62.

NOCT_MOUSE
NC score	0.010804 (rank : 79)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	O35710, Q9QZG9	Gene names	Ccrn4l, Ccr4, Noc
Domain Architecture
Description	Nocturnin (CCR4 protein homolog).

CI039_HUMAN
NC score	0.009922 (rank : 80)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	1171	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

SEPT9_HUMAN
NC score	0.009707 (rank : 81)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	706	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

ATRX_HUMAN
NC score	0.008923 (rank : 82)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	842	Shared Neighborhood Hits	13
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

ARHGA_HUMAN
NC score	0.008749 (rank : 83)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	187	Shared Neighborhood Hits	5
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

CHD9_HUMAN
NC score	0.008543 (rank : 84)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	343	Shared Neighborhood Hits	8
SwissProt Accessions	Q3L8U1, O15025, Q1WF12, Q6DTK9, Q9H9V7	Gene names	CHD9, KIAA0308, KISH2, PRIC320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin remodeling factor CHROM1) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha-interacting complex protein 320 kDa) (Kismet homolog 2).

DYNA_MOUSE
NC score	0.008298 (rank : 85)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	1084	Shared Neighborhood Hits	15
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

CHD9_MOUSE
NC score	0.008255 (rank : 86)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	427	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

IFT81_MOUSE
NC score	0.007330 (rank : 87)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	959	Shared Neighborhood Hits	19
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

DDX11_MOUSE
NC score	0.006770 (rank : 88)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q6AXC6	Gene names	Ddx11
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-) (DEAD/H box protein 11).

RYR1_HUMAN
NC score	0.005227 (rank : 89)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	303	Shared Neighborhood Hits	7
SwissProt Accessions	P21817, Q16314, Q16368, Q9NPK1, Q9P1U4	Gene names	RYR1, RYDR
Domain Architecture
Description	Ryanodine receptor 1 (Skeletal muscle-type ryanodine receptor) (RyR1) (RYR-1) (Skeletal muscle calcium release channel).

DMD_MOUSE
NC score	0.005160 (rank : 90)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	1111	Shared Neighborhood Hits	15
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

UTRO_HUMAN
NC score	0.005144 (rank : 91)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	960	Shared Neighborhood Hits	14
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

ENOA_HUMAN
NC score	0.004924 (rank : 92)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P06733, P22712, Q16704, Q4TUS4, Q658M5, Q6GMP2, Q71V37, Q7Z3V6, Q8WU71, Q9UM55	Gene names	ENO1, ENO1L1, MBPB1, MPB1
Domain Architecture
Description	Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Non- neural enolase) (NNE) (Enolase 1) (Phosphopyruvate hydratase) (C-myc promoter-binding protein) (MBP-1) (MPB-1) (Plasminogen-binding protein).

ANR47_MOUSE
NC score	0.004705 (rank : 93)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	350	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

REST_MOUSE
NC score	0.004704 (rank : 94)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	1506	Shared Neighborhood Hits	21
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

WRN_MOUSE
NC score	0.004474 (rank : 95)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	295	Shared Neighborhood Hits	6
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

HS74L_MOUSE
NC score	0.004182 (rank : 96)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	141	Shared Neighborhood Hits	6
SwissProt Accessions	P48722, P97854, Q8BQD0, Q8CC45, Q91X29	Gene names	Hspa4l, Apg1, Hsp4l, Osp94
Domain Architecture
Description	Heat shock 70 kDa protein 4L (Osmotic stress protein 94) (Heat shock 70-related protein APG-1).

CENPE_HUMAN
NC score	0.004140 (rank : 97)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	2060	Shared Neighborhood Hits	20
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

ADAM2_MOUSE
NC score	0.003598 (rank : 98)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	209	Shared Neighborhood Hits	2
SwissProt Accessions	Q60718, Q60814, Q9D4G3, Q9QWJ0	Gene names	Adam2, Ftnb
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta).

SRBS1_MOUSE
NC score	0.003277 (rank : 99)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	409	Shared Neighborhood Hits	2
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

LGR6_HUMAN
NC score	0.001411 (rank : 100)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	344	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBX8, Q5T509, Q5T512, Q6UY15, Q86VU0, Q96K69, Q9BYD7	Gene names	LGR6
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 6 (VTS20631).

MINK1_MOUSE
NC score	0.000568 (rank : 101)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	1451	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

ZFX_MOUSE
NC score	-0.001448 (rank : 102)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	748	Shared Neighborhood Hits	5
SwissProt Accessions	P17012, P17011	Gene names	Zfx
Domain Architecture
Description	Zinc finger X-chromosomal protein.

ZFX_HUMAN
NC score	-0.001455 (rank : 103)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	751	Shared Neighborhood Hits	5
SwissProt Accessions	P17010, O43668, Q8WYJ8	Gene names	ZFX
Domain Architecture
Description	Zinc finger X-chromosomal protein.

TCF8_HUMAN
NC score	-0.001580 (rank : 104)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	1057	Shared Neighborhood Hits	10
SwissProt Accessions	P37275, Q12924, Q13800	Gene names	TCF8, AREB6
Domain Architecture
Description	Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2).

ZFA_MOUSE
NC score	-0.001610 (rank : 105)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	746	Shared Neighborhood Hits	5
SwissProt Accessions	P23607	Gene names	Zfa
Domain Architecture
Description	Zinc finger autosomal protein.