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Network neighborhood for query Sequence : PKHA1_MOUSE

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PKHA1_MOUSE
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PKHA1_MOUSE
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	120	Target Neighborhood Hits	120	Shared Neighborhood Hits	120
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_HUMAN
θ value	8.28183e-171 (rank : 2)	NC score	0.994513 (rank : 2)
Query Neighborhood Hits	120	Target Neighborhood Hits	127	Shared Neighborhood Hits	115
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_MOUSE
θ value	9.056e-93 (rank : 3)	NC score	0.939955 (rank : 3)
Query Neighborhood Hits	120	Target Neighborhood Hits	116	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA2_HUMAN
θ value	6.48998e-91 (rank : 4)	NC score	0.936310 (rank : 4)
Query Neighborhood Hits	120	Target Neighborhood Hits	119	Shared Neighborhood Hits	87
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

DAPP1_MOUSE
θ value	3.52202e-12 (rank : 5)	NC score	0.479350 (rank : 10)
Query Neighborhood Hits	120	Target Neighborhood Hits	225	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_HUMAN
θ value	4.59992e-12 (rank : 6)	NC score	0.474949 (rank : 12)
Query Neighborhood Hits	120	Target Neighborhood Hits	227	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA6_HUMAN
θ value	3.89403e-11 (rank : 7)	NC score	0.481592 (rank : 9)
Query Neighborhood Hits	120	Target Neighborhood Hits	556	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	1.47974e-10 (rank : 8)	NC score	0.476677 (rank : 11)
Query Neighborhood Hits	120	Target Neighborhood Hits	591	Shared Neighborhood Hits	88
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

GAB1_HUMAN
θ value	6.21693e-09 (rank : 9)	NC score	0.397588 (rank : 18)
Query Neighborhood Hits	120	Target Neighborhood Hits	279	Shared Neighborhood Hits	49
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

RASA3_HUMAN
θ value	2.36244e-08 (rank : 10)	NC score	0.302999 (rank : 27)
Query Neighborhood Hits	120	Target Neighborhood Hits	166	Shared Neighborhood Hits	49
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

GAB1_MOUSE
θ value	3.08544e-08 (rank : 11)	NC score	0.383374 (rank : 20)
Query Neighborhood Hits	120	Target Neighborhood Hits	233	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CYH3_MOUSE
θ value	4.0297e-08 (rank : 12)	NC score	0.409636 (rank : 14)
Query Neighborhood Hits	120	Target Neighborhood Hits	148	Shared Neighborhood Hits	85
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH1_HUMAN
θ value	5.26297e-08 (rank : 13)	NC score	0.413506 (rank : 13)
Query Neighborhood Hits	120	Target Neighborhood Hits	184	Shared Neighborhood Hits	85
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	5.26297e-08 (rank : 14)	NC score	0.409528 (rank : 15)
Query Neighborhood Hits	120	Target Neighborhood Hits	176	Shared Neighborhood Hits	82
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

PLEK2_HUMAN
θ value	8.97725e-08 (rank : 15)	NC score	0.501225 (rank : 7)
Query Neighborhood Hits	120	Target Neighborhood Hits	101	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	1.53129e-07 (rank : 16)	NC score	0.497666 (rank : 8)
Query Neighborhood Hits	120	Target Neighborhood Hits	96	Shared Neighborhood Hits	67
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

GAB2_MOUSE
θ value	1.99992e-07 (rank : 17)	NC score	0.402944 (rank : 16)
Query Neighborhood Hits	120	Target Neighborhood Hits	220	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

PLEK_MOUSE
θ value	2.61198e-07 (rank : 18)	NC score	0.523503 (rank : 6)
Query Neighborhood Hits	120	Target Neighborhood Hits	109	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

RASA3_MOUSE
θ value	2.61198e-07 (rank : 19)	NC score	0.297029 (rank : 29)
Query Neighborhood Hits	120	Target Neighborhood Hits	144	Shared Neighborhood Hits	45
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

AKT2_MOUSE
θ value	3.41135e-07 (rank : 20)	NC score	0.092588 (rank : 106)
Query Neighborhood Hits	120	Target Neighborhood Hits	875	Shared Neighborhood Hits	52
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

PLEK_HUMAN
θ value	3.41135e-07 (rank : 21)	NC score	0.537981 (rank : 5)
Query Neighborhood Hits	120	Target Neighborhood Hits	110	Shared Neighborhood Hits	74
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

CENB2_HUMAN
θ value	4.45536e-07 (rank : 22)	NC score	0.271529 (rank : 37)
Query Neighborhood Hits	120	Target Neighborhood Hits	425	Shared Neighborhood Hits	65
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CEND1_HUMAN
θ value	1.29631e-06 (rank : 23)	NC score	0.277873 (rank : 34)
Query Neighborhood Hits	120	Target Neighborhood Hits	284	Shared Neighborhood Hits	69
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

SWP70_MOUSE
θ value	1.29631e-06 (rank : 24)	NC score	0.250858 (rank : 44)
Query Neighborhood Hits	120	Target Neighborhood Hits	1097	Shared Neighborhood Hits	77
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CEND2_HUMAN
θ value	1.69304e-06 (rank : 25)	NC score	0.258878 (rank : 41)
Query Neighborhood Hits	120	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

GAB2_HUMAN
θ value	1.69304e-06 (rank : 26)	NC score	0.401204 (rank : 17)
Query Neighborhood Hits	120	Target Neighborhood Hits	188	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

SWP70_HUMAN
θ value	1.69304e-06 (rank : 27)	NC score	0.257300 (rank : 42)
Query Neighborhood Hits	120	Target Neighborhood Hits	973	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

AKT2_HUMAN
θ value	2.21117e-06 (rank : 28)	NC score	0.091274 (rank : 108)
Query Neighborhood Hits	120	Target Neighborhood Hits	878	Shared Neighborhood Hits	53
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

CYH3_HUMAN
θ value	2.21117e-06 (rank : 29)	NC score	0.393341 (rank : 19)
Query Neighborhood Hits	120	Target Neighborhood Hits	137	Shared Neighborhood Hits	79
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

MYO10_HUMAN
θ value	2.88788e-06 (rank : 30)	NC score	0.151826 (rank : 65)
Query Neighborhood Hits	120	Target Neighborhood Hits	920	Shared Neighborhood Hits	91
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

CENB1_HUMAN
θ value	3.77169e-06 (rank : 31)	NC score	0.245986 (rank : 45)
Query Neighborhood Hits	120	Target Neighborhood Hits	383	Shared Neighborhood Hits	61
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CYH4_MOUSE
θ value	8.40245e-06 (rank : 32)	NC score	0.379761 (rank : 23)
Query Neighborhood Hits	120	Target Neighborhood Hits	134	Shared Neighborhood Hits	73
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH2_HUMAN
θ value	1.09739e-05 (rank : 33)	NC score	0.382927 (rank : 22)
Query Neighborhood Hits	120	Target Neighborhood Hits	175	Shared Neighborhood Hits	82
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	1.09739e-05 (rank : 34)	NC score	0.383060 (rank : 21)
Query Neighborhood Hits	120	Target Neighborhood Hits	171	Shared Neighborhood Hits	82
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH4_HUMAN
θ value	1.09739e-05 (rank : 35)	NC score	0.379222 (rank : 24)
Query Neighborhood Hits	120	Target Neighborhood Hits	135	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

PHLB2_MOUSE
θ value	1.09739e-05 (rank : 36)	NC score	0.210523 (rank : 56)
Query Neighborhood Hits	120	Target Neighborhood Hits	1016	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

RHG25_MOUSE
θ value	1.87187e-05 (rank : 37)	NC score	0.285885 (rank : 31)
Query Neighborhood Hits	120	Target Neighborhood Hits	492	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RASA2_MOUSE
θ value	2.44474e-05 (rank : 38)	NC score	0.286058 (rank : 30)
Query Neighborhood Hits	120	Target Neighborhood Hits	159	Shared Neighborhood Hits	45
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

PHLB2_HUMAN
θ value	3.19293e-05 (rank : 39)	NC score	0.208589 (rank : 57)
Query Neighborhood Hits	120	Target Neighborhood Hits	964	Shared Neighborhood Hits	58
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PKHA5_HUMAN
θ value	3.19293e-05 (rank : 40)	NC score	0.356955 (rank : 25)
Query Neighborhood Hits	120	Target Neighborhood Hits	455	Shared Neighborhood Hits	76
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RASA2_HUMAN
θ value	3.19293e-05 (rank : 41)	NC score	0.272105 (rank : 36)
Query Neighborhood Hits	120	Target Neighborhood Hits	157	Shared Neighborhood Hits	41
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

AKT3_HUMAN
θ value	9.29e-05 (rank : 42)	NC score	0.081162 (rank : 120)
Query Neighborhood Hits	120	Target Neighborhood Hits	872	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	9.29e-05 (rank : 43)	NC score	0.081148 (rank : 121)
Query Neighborhood Hits	120	Target Neighborhood Hits	872	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

CEND1_MOUSE
θ value	9.29e-05 (rank : 44)	NC score	0.240113 (rank : 47)
Query Neighborhood Hits	120	Target Neighborhood Hits	260	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CENB5_HUMAN
θ value	0.000158464 (rank : 45)	NC score	0.251597 (rank : 43)
Query Neighborhood Hits	120	Target Neighborhood Hits	395	Shared Neighborhood Hits	66
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

AKT1_HUMAN
θ value	0.00020696 (rank : 46)	NC score	0.084450 (rank : 113)
Query Neighborhood Hits	120	Target Neighborhood Hits	885	Shared Neighborhood Hits	56
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

RHG25_HUMAN
θ value	0.00020696 (rank : 47)	NC score	0.281505 (rank : 32)
Query Neighborhood Hits	120	Target Neighborhood Hits	550	Shared Neighborhood Hits	77
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RASA1_HUMAN
θ value	0.000270298 (rank : 48)	NC score	0.278769 (rank : 33)
Query Neighborhood Hits	120	Target Neighborhood Hits	258	Shared Neighborhood Hits	57
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

PHLB1_MOUSE
θ value	0.000461057 (rank : 49)	NC score	0.243672 (rank : 46)
Query Neighborhood Hits	120	Target Neighborhood Hits	678	Shared Neighborhood Hits	55
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

AKT1_MOUSE
θ value	0.000602161 (rank : 50)	NC score	0.083912 (rank : 114)
Query Neighborhood Hits	120	Target Neighborhood Hits	878	Shared Neighborhood Hits	55
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

CEND3_HUMAN
θ value	0.000786445 (rank : 51)	NC score	0.217885 (rank : 51)
Query Neighborhood Hits	120	Target Neighborhood Hits	275	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
θ value	0.00102713 (rank : 52)	NC score	0.216023 (rank : 52)
Query Neighborhood Hits	120	Target Neighborhood Hits	228	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

SPTN4_HUMAN
θ value	0.00102713 (rank : 53)	NC score	0.060333 (rank : 156)
Query Neighborhood Hits	120	Target Neighborhood Hits	570	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

C43BP_MOUSE
θ value	0.00134147 (rank : 54)	NC score	0.262173 (rank : 40)
Query Neighborhood Hits	120	Target Neighborhood Hits	91	Shared Neighborhood Hits	53
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

FARP2_MOUSE
θ value	0.00134147 (rank : 55)	NC score	0.125039 (rank : 79)
Query Neighborhood Hits	120	Target Neighborhood Hits	209	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARBK1_HUMAN
θ value	0.00228821 (rank : 56)	NC score	0.061931 (rank : 150)
Query Neighborhood Hits	120	Target Neighborhood Hits	859	Shared Neighborhood Hits	32
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
θ value	0.00228821 (rank : 57)	NC score	0.061216 (rank : 152)
Query Neighborhood Hits	120	Target Neighborhood Hits	849	Shared Neighborhood Hits	31
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

DGKH_HUMAN
θ value	0.00228821 (rank : 58)	NC score	0.219066 (rank : 50)
Query Neighborhood Hits	120	Target Neighborhood Hits	255	Shared Neighborhood Hits	68
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

PHLB1_HUMAN
θ value	0.00228821 (rank : 59)	NC score	0.202177 (rank : 58)
Query Neighborhood Hits	120	Target Neighborhood Hits	1038	Shared Neighborhood Hits	54
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

DGKD_HUMAN
θ value	0.00298849 (rank : 60)	NC score	0.178890 (rank : 61)
Query Neighborhood Hits	120	Target Neighborhood Hits	231	Shared Neighborhood Hits	46
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

KPCD3_HUMAN
θ value	0.00298849 (rank : 61)	NC score	0.056644 (rank : 163)
Query Neighborhood Hits	120	Target Neighborhood Hits	895	Shared Neighborhood Hits	24
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

3BP2_HUMAN
θ value	0.00390308 (rank : 62)	NC score	0.273804 (rank : 35)
Query Neighborhood Hits	120	Target Neighborhood Hits	296	Shared Neighborhood Hits	39
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	0.00509761 (rank : 63)	NC score	0.266448 (rank : 38)
Query Neighborhood Hits	120	Target Neighborhood Hits	142	Shared Neighborhood Hits	37
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

KPCD1_HUMAN
θ value	0.00509761 (rank : 64)	NC score	0.055812 (rank : 167)
Query Neighborhood Hits	120	Target Neighborhood Hits	901	Shared Neighborhood Hits	26
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD3_MOUSE
θ value	0.00509761 (rank : 65)	NC score	0.056232 (rank : 165)
Query Neighborhood Hits	120	Target Neighborhood Hits	901	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

PKHB2_MOUSE
θ value	0.00509761 (rank : 66)	NC score	0.266326 (rank : 39)
Query Neighborhood Hits	120	Target Neighborhood Hits	48	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

FARP2_HUMAN
θ value	0.00665767 (rank : 67)	NC score	0.118184 (rank : 86)
Query Neighborhood Hits	120	Target Neighborhood Hits	240	Shared Neighborhood Hits	39
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

C43BP_HUMAN
θ value	0.00869519 (rank : 68)	NC score	0.238224 (rank : 48)
Query Neighborhood Hits	120	Target Neighborhood Hits	87	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CENA1_HUMAN
θ value	0.0193708 (rank : 69)	NC score	0.213422 (rank : 54)
Query Neighborhood Hits	120	Target Neighborhood Hits	87	Shared Neighborhood Hits	49
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

MTMR5_HUMAN
θ value	0.0193708 (rank : 70)	NC score	0.149836 (rank : 66)
Query Neighborhood Hits	120	Target Neighborhood Hits	141	Shared Neighborhood Hits	49
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

RASL1_HUMAN
θ value	0.0330416 (rank : 71)	NC score	0.136217 (rank : 71)
Query Neighborhood Hits	120	Target Neighborhood Hits	142	Shared Neighborhood Hits	17
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

TBCD2_HUMAN
θ value	0.0330416 (rank : 72)	NC score	0.152293 (rank : 64)
Query Neighborhood Hits	120	Target Neighborhood Hits	419	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

TEC_MOUSE
θ value	0.0330416 (rank : 73)	NC score	0.053203 (rank : 177)
Query Neighborhood Hits	120	Target Neighborhood Hits	1006	Shared Neighborhood Hits	47
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

PSD3_HUMAN
θ value	0.0431538 (rank : 74)	NC score	0.237566 (rank : 49)
Query Neighborhood Hits	120	Target Neighborhood Hits	75	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

KPCD1_MOUSE
θ value	0.0961366 (rank : 75)	NC score	0.052902 (rank : 181)
Query Neighborhood Hits	120	Target Neighborhood Hits	891	Shared Neighborhood Hits	24
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

PKHB2_HUMAN
θ value	0.0961366 (rank : 76)	NC score	0.215146 (rank : 53)
Query Neighborhood Hits	120	Target Neighborhood Hits	54	Shared Neighborhood Hits	38
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

TEC_HUMAN
θ value	0.0961366 (rank : 77)	NC score	0.055953 (rank : 166)
Query Neighborhood Hits	120	Target Neighborhood Hits	1006	Shared Neighborhood Hits	46
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

RASL1_MOUSE
θ value	0.125558 (rank : 78)	NC score	0.143872 (rank : 68)
Query Neighborhood Hits	120	Target Neighborhood Hits	148	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

FARP1_HUMAN
θ value	0.163984 (rank : 79)	NC score	0.113375 (rank : 91)
Query Neighborhood Hits	120	Target Neighborhood Hits	241	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PKHA4_MOUSE
θ value	0.163984 (rank : 80)	NC score	0.326054 (rank : 26)
Query Neighborhood Hits	120	Target Neighborhood Hits	202	Shared Neighborhood Hits	60
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

DGKK_HUMAN
θ value	0.21417 (rank : 81)	NC score	0.104570 (rank : 97)
Query Neighborhood Hits	120	Target Neighborhood Hits	378	Shared Neighborhood Hits	31
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

KPCD2_HUMAN
θ value	0.21417 (rank : 82)	NC score	0.050883 (rank : 187)
Query Neighborhood Hits	120	Target Neighborhood Hits	910	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

OSBL9_HUMAN
θ value	0.21417 (rank : 83)	NC score	0.136054 (rank : 72)
Query Neighborhood Hits	120	Target Neighborhood Hits	138	Shared Neighborhood Hits	50
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

BMX_HUMAN
θ value	0.279714 (rank : 84)	NC score	0.055315 (rank : 170)
Query Neighborhood Hits	120	Target Neighborhood Hits	942	Shared Neighborhood Hits	55
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	0.365318 (rank : 85)	NC score	0.052278 (rank : 183)
Query Neighborhood Hits	120	Target Neighborhood Hits	912	Shared Neighborhood Hits	52
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

CENA2_HUMAN
θ value	0.365318 (rank : 86)	NC score	0.212942 (rank : 55)
Query Neighborhood Hits	120	Target Neighborhood Hits	83	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENA2_MOUSE
θ value	0.365318 (rank : 87)	NC score	0.179340 (rank : 60)
Query Neighborhood Hits	120	Target Neighborhood Hits	68	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

PKHA4_HUMAN
θ value	0.365318 (rank : 88)	NC score	0.300563 (rank : 28)
Query Neighborhood Hits	120	Target Neighborhood Hits	283	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

KIF1A_HUMAN
θ value	0.47712 (rank : 89)	NC score	0.038377 (rank : 196)
Query Neighborhood Hits	120	Target Neighborhood Hits	240	Shared Neighborhood Hits	14
SwissProt Accessions	Q12756	Gene names	KIF1A, ATSV
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

KIF1A_MOUSE
θ value	0.47712 (rank : 90)	NC score	0.041328 (rank : 193)
Query Neighborhood Hits	120	Target Neighborhood Hits	239	Shared Neighborhood Hits	16
SwissProt Accessions	P33173, Q61770	Gene names	Kif1a, Atsv, Kif1
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

MRIP_MOUSE
θ value	0.47712 (rank : 91)	NC score	0.121034 (rank : 82)
Query Neighborhood Hits	120	Target Neighborhood Hits	569	Shared Neighborhood Hits	58
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

DOC10_HUMAN
θ value	0.62314 (rank : 92)	NC score	0.060557 (rank : 155)
Query Neighborhood Hits	120	Target Neighborhood Hits	88	Shared Neighborhood Hits	23
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

DYN2_HUMAN
θ value	0.62314 (rank : 93)	NC score	0.082373 (rank : 119)
Query Neighborhood Hits	120	Target Neighborhood Hits	112	Shared Neighborhood Hits	26
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
θ value	0.62314 (rank : 94)	NC score	0.082398 (rank : 118)
Query Neighborhood Hits	120	Target Neighborhood Hits	104	Shared Neighborhood Hits	26
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

MTMRD_HUMAN
θ value	0.62314 (rank : 95)	NC score	0.147415 (rank : 67)
Query Neighborhood Hits	120	Target Neighborhood Hits	135	Shared Neighborhood Hits	61
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

DYN3_HUMAN
θ value	0.813845 (rank : 96)	NC score	0.082547 (rank : 117)
Query Neighborhood Hits	120	Target Neighborhood Hits	158	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

KIF1B_HUMAN
θ value	0.813845 (rank : 97)	NC score	0.038544 (rank : 195)
Query Neighborhood Hits	120	Target Neighborhood Hits	178	Shared Neighborhood Hits	15
SwissProt Accessions	O60333, Q96Q94, Q9BV80, Q9P280	Gene names	KIF1B, KIAA0591, KIAA1448
Domain Architecture
Description	Kinesin-like protein KIF1B (Klp).

KIF1B_MOUSE
θ value	0.813845 (rank : 98)	NC score	0.037375 (rank : 198)
Query Neighborhood Hits	120	Target Neighborhood Hits	167	Shared Neighborhood Hits	16
SwissProt Accessions	Q60575, Q9R0B4, Q9WVE5, Q9Z119	Gene names	Kif1b
Domain Architecture
Description	Kinesin-like protein KIF1B.

DDFL1_HUMAN
θ value	1.06291 (rank : 99)	NC score	0.128048 (rank : 78)
Query Neighborhood Hits	120	Target Neighborhood Hits	353	Shared Neighborhood Hits	33
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

SNTA1_MOUSE
θ value	1.06291 (rank : 100)	NC score	0.015519 (rank : 201)
Query Neighborhood Hits	120	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

OSBP1_HUMAN
θ value	1.38821 (rank : 101)	NC score	0.120634 (rank : 84)
Query Neighborhood Hits	120	Target Neighborhood Hits	180	Shared Neighborhood Hits	56
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

ARBK2_HUMAN
θ value	1.81305 (rank : 102)	NC score	0.052581 (rank : 182)
Query Neighborhood Hits	120	Target Neighborhood Hits	849	Shared Neighborhood Hits	26
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

MRIP_HUMAN
θ value	1.81305 (rank : 103)	NC score	0.115843 (rank : 88)
Query Neighborhood Hits	120	Target Neighborhood Hits	578	Shared Neighborhood Hits	58
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

SPTB2_MOUSE
θ value	1.81305 (rank : 104)	NC score	0.037526 (rank : 197)
Query Neighborhood Hits	120	Target Neighborhood Hits	770	Shared Neighborhood Hits	29
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

ARHG7_HUMAN
θ value	2.36792 (rank : 105)	NC score	0.034722 (rank : 199)
Query Neighborhood Hits	120	Target Neighborhood Hits	347	Shared Neighborhood Hits	15
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

K1688_HUMAN
θ value	2.36792 (rank : 106)	NC score	0.052915 (rank : 180)
Query Neighborhood Hits	120	Target Neighborhood Hits	217	Shared Neighborhood Hits	10
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

K1688_MOUSE
θ value	2.36792 (rank : 107)	NC score	0.054349 (rank : 174)
Query Neighborhood Hits	120	Target Neighborhood Hits	188	Shared Neighborhood Hits	11
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

ESR2_HUMAN
θ value	3.0926 (rank : 108)	NC score	0.003703 (rank : 203)
Query Neighborhood Hits	120	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q92731, O60608, O60685, O60702, O60703, O75583, O75584, Q86Z31, Q9UEV6, Q9UHD3, Q9UQK9	Gene names	ESR2, ESTRB, NR3A2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

OSBL3_HUMAN
θ value	3.0926 (rank : 109)	NC score	0.062730 (rank : 149)
Query Neighborhood Hits	120	Target Neighborhood Hits	93	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

SPTB2_HUMAN
θ value	3.0926 (rank : 110)	NC score	0.038967 (rank : 194)
Query Neighborhood Hits	120	Target Neighborhood Hits	748	Shared Neighborhood Hits	27
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

DDEF1_MOUSE
θ value	4.03905 (rank : 111)	NC score	0.121625 (rank : 80)
Query Neighborhood Hits	120	Target Neighborhood Hits	592	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

IRS1_HUMAN
θ value	4.03905 (rank : 112)	NC score	0.055292 (rank : 171)
Query Neighborhood Hits	120	Target Neighborhood Hits	109	Shared Neighborhood Hits	16
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

CCD21_HUMAN
θ value	5.27518 (rank : 113)	NC score	0.019778 (rank : 200)
Query Neighborhood Hits	120	Target Neighborhood Hits	1228	Shared Neighborhood Hits	18
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

OSBP2_MOUSE
θ value	5.27518 (rank : 114)	NC score	0.096406 (rank : 101)
Query Neighborhood Hits	120	Target Neighborhood Hits	150	Shared Neighborhood Hits	46
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

SNTA1_HUMAN
θ value	5.27518 (rank : 115)	NC score	0.013673 (rank : 202)
Query Neighborhood Hits	120	Target Neighborhood Hits	186	Shared Neighborhood Hits	5
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

DDEF2_HUMAN
θ value	6.88961 (rank : 116)	NC score	0.102823 (rank : 99)
Query Neighborhood Hits	120	Target Neighborhood Hits	599	Shared Neighborhood Hits	38
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	6.88961 (rank : 117)	NC score	0.100866 (rank : 100)
Query Neighborhood Hits	120	Target Neighborhood Hits	625	Shared Neighborhood Hits	37
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDFL1_MOUSE
θ value	6.88961 (rank : 118)	NC score	0.111514 (rank : 93)
Query Neighborhood Hits	120	Target Neighborhood Hits	324	Shared Neighborhood Hits	30
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

GNRP_MOUSE
θ value	8.99809 (rank : 119)	NC score	0.092486 (rank : 107)
Query Neighborhood Hits	120	Target Neighborhood Hits	191	Shared Neighborhood Hits	43
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

IRS1_MOUSE
θ value	8.99809 (rank : 120)	NC score	0.047663 (rank : 192)
Query Neighborhood Hits	120	Target Neighborhood Hits	112	Shared Neighborhood Hits	14
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

ABR_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.051419 (rank : 185)
Query Neighborhood Hits	120	Target Neighborhood Hits	166	Shared Neighborhood Hits	14
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ANLN_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.080132 (rank : 122)
Query Neighborhood Hits	120	Target Neighborhood Hits	222	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

ANLN_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.066532 (rank : 139)
Query Neighborhood Hits	120	Target Neighborhood Hits	297	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

ARFG1_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.082643 (rank : 116)
Query Neighborhood Hits	120	Target Neighborhood Hits	60	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG1_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.085055 (rank : 111)
Query Neighborhood Hits	120	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG3_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.084570 (rank : 112)
Query Neighborhood Hits	120	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.083862 (rank : 115)
Query Neighborhood Hits	120	Target Neighborhood Hits	80	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

BCR_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.050159 (rank : 190)
Query Neighborhood Hits	120	Target Neighborhood Hits	204	Shared Neighborhood Hits	15
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BIG1_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.130898 (rank : 77)
Query Neighborhood Hits	120	Target Neighborhood Hits	76	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BIG2_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.132628 (rank : 74)
Query Neighborhood Hits	120	Target Neighborhood Hits	66	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

CENG1_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.074659 (rank : 129)
Query Neighborhood Hits	120	Target Neighborhood Hits	544	Shared Neighborhood Hits	26
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG1_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.075735 (rank : 128)
Query Neighborhood Hits	120	Target Neighborhood Hits	531	Shared Neighborhood Hits	27
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG2_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.065881 (rank : 142)
Query Neighborhood Hits	120	Target Neighborhood Hits	471	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG2_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.065503 (rank : 143)
Query Neighborhood Hits	120	Target Neighborhood Hits	463	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG3_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.072458 (rank : 130)
Query Neighborhood Hits	120	Target Neighborhood Hits	455	Shared Neighborhood Hits	22
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.072344 (rank : 131)
Query Neighborhood Hits	120	Target Neighborhood Hits	467	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CHIN_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.070630 (rank : 133)
Query Neighborhood Hits	120	Target Neighborhood Hits	227	Shared Neighborhood Hits	19
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.070154 (rank : 134)
Query Neighborhood Hits	120	Target Neighborhood Hits	229	Shared Neighborhood Hits	19
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.067068 (rank : 136)
Query Neighborhood Hits	120	Target Neighborhood Hits	220	Shared Neighborhood Hits	19
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.059831 (rank : 157)
Query Neighborhood Hits	120	Target Neighborhood Hits	130	Shared Neighborhood Hits	16
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CNKR1_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.197512 (rank : 59)
Query Neighborhood Hits	120	Target Neighborhood Hits	154	Shared Neighborhood Hits	49
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.162762 (rank : 63)
Query Neighborhood Hits	120	Target Neighborhood Hits	197	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.163122 (rank : 62)
Query Neighborhood Hits	120	Target Neighborhood Hits	197	Shared Neighborhood Hits	50
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

DAB2P_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.077165 (rank : 127)
Query Neighborhood Hits	120	Target Neighborhood Hits	303	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

DAB2P_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.077585 (rank : 124)
Query Neighborhood Hits	120	Target Neighborhood Hits	284	Shared Neighborhood Hits	14
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

DOCK9_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.054163 (rank : 175)
Query Neighborhood Hits	120	Target Neighborhood Hits	82	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK9_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.055316 (rank : 169)
Query Neighborhood Hits	120	Target Neighborhood Hits	79	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DYN1_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.050073 (rank : 191)
Query Neighborhood Hits	120	Target Neighborhood Hits	216	Shared Neighborhood Hits	21
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

FBX8_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.120767 (rank : 83)
Query Neighborhood Hits	120	Target Neighborhood Hits	44	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

FBX8_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.121265 (rank : 81)
Query Neighborhood Hits	120	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FGD4_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.050872 (rank : 188)
Query Neighborhood Hits	120	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD5_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.057139 (rank : 161)
Query Neighborhood Hits	120	Target Neighborhood Hits	235	Shared Neighborhood Hits	34
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.053247 (rank : 176)
Query Neighborhood Hits	120	Target Neighborhood Hits	170	Shared Neighborhood Hits	28
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD6_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.061149 (rank : 154)
Query Neighborhood Hits	120	Target Neighborhood Hits	237	Shared Neighborhood Hits	45
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.063645 (rank : 147)
Query Neighborhood Hits	120	Target Neighborhood Hits	282	Shared Neighborhood Hits	40
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

GBF1_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.132768 (rank : 73)
Query Neighborhood Hits	120	Target Neighborhood Hits	142	Shared Neighborhood Hits	9
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

GIT1_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.066755 (rank : 137)
Query Neighborhood Hits	120	Target Neighborhood Hits	336	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.066100 (rank : 140)
Query Neighborhood Hits	120	Target Neighborhood Hits	341	Shared Neighborhood Hits	21
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

GIT2_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.063990 (rank : 146)
Query Neighborhood Hits	120	Target Neighborhood Hits	381	Shared Neighborhood Hits	17
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.063429 (rank : 148)
Query Neighborhood Hits	120	Target Neighborhood Hits	323	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

GMIP_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.051262 (rank : 186)
Query Neighborhood Hits	120	Target Neighborhood Hits	202	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GNRP_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.090051 (rank : 109)
Query Neighborhood Hits	120	Target Neighborhood Hits	239	Shared Neighborhood Hits	42
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

HRBL_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.050538 (rank : 189)
Query Neighborhood Hits	120	Target Neighborhood Hits	179	Shared Neighborhood Hits	16
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

IQEC1_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.115734 (rank : 89)
Query Neighborhood Hits	120	Target Neighborhood Hits	76	Shared Neighborhood Hits	12
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC1_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.114590 (rank : 90)
Query Neighborhood Hits	120	Target Neighborhood Hits	54	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

IQEC2_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.105265 (rank : 96)
Query Neighborhood Hits	120	Target Neighborhood Hits	403	Shared Neighborhood Hits	15
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.105688 (rank : 95)
Query Neighborhood Hits	120	Target Neighborhood Hits	417	Shared Neighborhood Hits	15
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC3_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.119740 (rank : 85)
Query Neighborhood Hits	120	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC3_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.118136 (rank : 87)
Query Neighborhood Hits	120	Target Neighborhood Hits	274	Shared Neighborhood Hits	11
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

NF1_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.061208 (rank : 153)
Query Neighborhood Hits	120	Target Neighborhood Hits	56	Shared Neighborhood Hits	7
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

NF1_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.061632 (rank : 151)
Query Neighborhood Hits	120	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

NGAP_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.077271 (rank : 125)
Query Neighborhood Hits	120	Target Neighborhood Hits	517	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

NUPL_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.055573 (rank : 168)
Query Neighborhood Hits	120	Target Neighborhood Hits	68	Shared Neighborhood Hits	16
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.054826 (rank : 172)
Query Neighborhood Hits	120	Target Neighborhood Hits	113	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

OPHN1_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.065185 (rank : 144)
Query Neighborhood Hits	120	Target Neighborhood Hits	161	Shared Neighborhood Hits	15
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.066717 (rank : 138)
Query Neighborhood Hits	120	Target Neighborhood Hits	174	Shared Neighborhood Hits	17
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

OSB10_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.051728 (rank : 184)
Query Neighborhood Hits	120	Target Neighborhood Hits	55	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

OSB11_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.070046 (rank : 135)
Query Neighborhood Hits	120	Target Neighborhood Hits	60	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB11_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.071507 (rank : 132)
Query Neighborhood Hits	120	Target Neighborhood Hits	71	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSBL3_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.057452 (rank : 159)
Query Neighborhood Hits	120	Target Neighborhood Hits	86	Shared Neighborhood Hits	36
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBP2_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.089847 (rank : 110)
Query Neighborhood Hits	120	Target Neighborhood Hits	154	Shared Neighborhood Hits	49
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

PKHA3_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.109361 (rank : 94)
Query Neighborhood Hits	120	Target Neighborhood Hits	66	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.112241 (rank : 92)
Query Neighborhood Hits	120	Target Neighborhood Hits	67	Shared Neighborhood Hits	37
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHB1_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.132280 (rank : 76)
Query Neighborhood Hits	120	Target Neighborhood Hits	46	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB1_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.132384 (rank : 75)
Query Neighborhood Hits	120	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PSD4_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.139487 (rank : 70)
Query Neighborhood Hits	120	Target Neighborhood Hits	178	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

PSD4_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.142621 (rank : 69)
Query Neighborhood Hits	120	Target Neighborhood Hits	78	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

RASL2_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.103732 (rank : 98)
Query Neighborhood Hits	120	Target Neighborhood Hits	161	Shared Neighborhood Hits	12
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RBP1_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.054383 (rank : 173)
Query Neighborhood Hits	120	Target Neighborhood Hits	521	Shared Neighborhood Hits	17
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.052955 (rank : 179)
Query Neighborhood Hits	120	Target Neighborhood Hits	493	Shared Neighborhood Hits	16
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RGAP1_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.053035 (rank : 178)
Query Neighborhood Hits	120	Target Neighborhood Hits	189	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGAP1_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.056797 (rank : 162)
Query Neighborhood Hits	120	Target Neighborhood Hits	185	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RHG09_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.057180 (rank : 160)
Query Neighborhood Hits	120	Target Neighborhood Hits	186	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.056233 (rank : 164)
Query Neighborhood Hits	120	Target Neighborhood Hits	190	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.064735 (rank : 145)
Query Neighborhood Hits	120	Target Neighborhood Hits	204	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG26_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.065908 (rank : 141)
Query Neighborhood Hits	120	Target Neighborhood Hits	281	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SMAP1_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.094229 (rank : 105)
Query Neighborhood Hits	120	Target Neighborhood Hits	98	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.095517 (rank : 104)
Query Neighborhood Hits	120	Target Neighborhood Hits	120	Shared Neighborhood Hits	16
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMP1L_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.095988 (rank : 102)
Query Neighborhood Hits	120	Target Neighborhood Hits	74	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.095662 (rank : 103)
Query Neighborhood Hits	120	Target Neighborhood Hits	70	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SYGP1_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.079985 (rank : 123)
Query Neighborhood Hits	120	Target Neighborhood Hits	589	Shared Neighborhood Hits	19
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

TARA_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.058711 (rank : 158)
Query Neighborhood Hits	120	Target Neighborhood Hits	1626	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TARA_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.077217 (rank : 126)
Query Neighborhood Hits	120	Target Neighborhood Hits	1133	Shared Neighborhood Hits	58
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

Hits sorted by NC score

PKHA1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	120	Target Neighborhood Hits	120	Shared Neighborhood Hits	120
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_HUMAN
NC score	0.994513 (rank : 2)	θ value	8.28183e-171 (rank : 2)
Query Neighborhood Hits	120	Target Neighborhood Hits	127	Shared Neighborhood Hits	115
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_MOUSE
NC score	0.939955 (rank : 3)	θ value	9.056e-93 (rank : 3)
Query Neighborhood Hits	120	Target Neighborhood Hits	116	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA2_HUMAN
NC score	0.936310 (rank : 4)	θ value	6.48998e-91 (rank : 4)
Query Neighborhood Hits	120	Target Neighborhood Hits	119	Shared Neighborhood Hits	87
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PLEK_HUMAN
NC score	0.537981 (rank : 5)	θ value	3.41135e-07 (rank : 21)
Query Neighborhood Hits	120	Target Neighborhood Hits	110	Shared Neighborhood Hits	74
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
NC score	0.523503 (rank : 6)	θ value	2.61198e-07 (rank : 18)
Query Neighborhood Hits	120	Target Neighborhood Hits	109	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PLEK2_HUMAN
NC score	0.501225 (rank : 7)	θ value	8.97725e-08 (rank : 15)
Query Neighborhood Hits	120	Target Neighborhood Hits	101	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
NC score	0.497666 (rank : 8)	θ value	1.53129e-07 (rank : 16)
Query Neighborhood Hits	120	Target Neighborhood Hits	96	Shared Neighborhood Hits	67
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PKHA6_HUMAN
NC score	0.481592 (rank : 9)	θ value	3.89403e-11 (rank : 7)
Query Neighborhood Hits	120	Target Neighborhood Hits	556	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

DAPP1_MOUSE
NC score	0.479350 (rank : 10)	θ value	3.52202e-12 (rank : 5)
Query Neighborhood Hits	120	Target Neighborhood Hits	225	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA6_MOUSE
NC score	0.476677 (rank : 11)	θ value	1.47974e-10 (rank : 8)
Query Neighborhood Hits	120	Target Neighborhood Hits	591	Shared Neighborhood Hits	88
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

DAPP1_HUMAN
NC score	0.474949 (rank : 12)	θ value	4.59992e-12 (rank : 6)
Query Neighborhood Hits	120	Target Neighborhood Hits	227	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CYH1_HUMAN
NC score	0.413506 (rank : 13)	θ value	5.26297e-08 (rank : 13)
Query Neighborhood Hits	120	Target Neighborhood Hits	184	Shared Neighborhood Hits	85
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH3_MOUSE
NC score	0.409636 (rank : 14)	θ value	4.0297e-08 (rank : 12)
Query Neighborhood Hits	120	Target Neighborhood Hits	148	Shared Neighborhood Hits	85
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH1_MOUSE
NC score	0.409528 (rank : 15)	θ value	5.26297e-08 (rank : 14)
Query Neighborhood Hits	120	Target Neighborhood Hits	176	Shared Neighborhood Hits	82
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

GAB2_MOUSE
NC score	0.402944 (rank : 16)	θ value	1.99992e-07 (rank : 17)
Query Neighborhood Hits	120	Target Neighborhood Hits	220	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GAB2_HUMAN
NC score	0.401204 (rank : 17)	θ value	1.69304e-06 (rank : 26)
Query Neighborhood Hits	120	Target Neighborhood Hits	188	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GAB1_HUMAN
NC score	0.397588 (rank : 18)	θ value	6.21693e-09 (rank : 9)
Query Neighborhood Hits	120	Target Neighborhood Hits	279	Shared Neighborhood Hits	49
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CYH3_HUMAN
NC score	0.393341 (rank : 19)	θ value	2.21117e-06 (rank : 29)
Query Neighborhood Hits	120	Target Neighborhood Hits	137	Shared Neighborhood Hits	79
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

GAB1_MOUSE
NC score	0.383374 (rank : 20)	θ value	3.08544e-08 (rank : 11)
Query Neighborhood Hits	120	Target Neighborhood Hits	233	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CYH2_MOUSE
NC score	0.383060 (rank : 21)	θ value	1.09739e-05 (rank : 34)
Query Neighborhood Hits	120	Target Neighborhood Hits	171	Shared Neighborhood Hits	82
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.382927 (rank : 22)	θ value	1.09739e-05 (rank : 33)
Query Neighborhood Hits	120	Target Neighborhood Hits	175	Shared Neighborhood Hits	82
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH4_MOUSE
NC score	0.379761 (rank : 23)	θ value	8.40245e-06 (rank : 32)
Query Neighborhood Hits	120	Target Neighborhood Hits	134	Shared Neighborhood Hits	73
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH4_HUMAN
NC score	0.379222 (rank : 24)	θ value	1.09739e-05 (rank : 35)
Query Neighborhood Hits	120	Target Neighborhood Hits	135	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

PKHA5_HUMAN
NC score	0.356955 (rank : 25)	θ value	3.19293e-05 (rank : 40)
Query Neighborhood Hits	120	Target Neighborhood Hits	455	Shared Neighborhood Hits	76
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA4_MOUSE
NC score	0.326054 (rank : 26)	θ value	0.163984 (rank : 80)
Query Neighborhood Hits	120	Target Neighborhood Hits	202	Shared Neighborhood Hits	60
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

RASA3_HUMAN
NC score	0.302999 (rank : 27)	θ value	2.36244e-08 (rank : 10)
Query Neighborhood Hits	120	Target Neighborhood Hits	166	Shared Neighborhood Hits	49
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

PKHA4_HUMAN
NC score	0.300563 (rank : 28)	θ value	0.365318 (rank : 88)
Query Neighborhood Hits	120	Target Neighborhood Hits	283	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

RASA3_MOUSE
NC score	0.297029 (rank : 29)	θ value	2.61198e-07 (rank : 19)
Query Neighborhood Hits	120	Target Neighborhood Hits	144	Shared Neighborhood Hits	45
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RASA2_MOUSE
NC score	0.286058 (rank : 30)	θ value	2.44474e-05 (rank : 38)
Query Neighborhood Hits	120	Target Neighborhood Hits	159	Shared Neighborhood Hits	45
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RHG25_MOUSE
NC score	0.285885 (rank : 31)	θ value	1.87187e-05 (rank : 37)
Query Neighborhood Hits	120	Target Neighborhood Hits	492	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_HUMAN
NC score	0.281505 (rank : 32)	θ value	0.00020696 (rank : 47)
Query Neighborhood Hits	120	Target Neighborhood Hits	550	Shared Neighborhood Hits	77
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RASA1_HUMAN
NC score	0.278769 (rank : 33)	θ value	0.000270298 (rank : 48)
Query Neighborhood Hits	120	Target Neighborhood Hits	258	Shared Neighborhood Hits	57
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

CEND1_HUMAN
NC score	0.277873 (rank : 34)	θ value	1.29631e-06 (rank : 23)
Query Neighborhood Hits	120	Target Neighborhood Hits	284	Shared Neighborhood Hits	69
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

3BP2_HUMAN
NC score	0.273804 (rank : 35)	θ value	0.00390308 (rank : 62)
Query Neighborhood Hits	120	Target Neighborhood Hits	296	Shared Neighborhood Hits	39
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

RASA2_HUMAN
NC score	0.272105 (rank : 36)	θ value	3.19293e-05 (rank : 41)
Query Neighborhood Hits	120	Target Neighborhood Hits	157	Shared Neighborhood Hits	41
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

CENB2_HUMAN
NC score	0.271529 (rank : 37)	θ value	4.45536e-07 (rank : 22)
Query Neighborhood Hits	120	Target Neighborhood Hits	425	Shared Neighborhood Hits	65
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

3BP2_MOUSE
NC score	0.266448 (rank : 38)	θ value	0.00509761 (rank : 63)
Query Neighborhood Hits	120	Target Neighborhood Hits	142	Shared Neighborhood Hits	37
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PKHB2_MOUSE
NC score	0.266326 (rank : 39)	θ value	0.00509761 (rank : 66)
Query Neighborhood Hits	120	Target Neighborhood Hits	48	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

C43BP_MOUSE
NC score	0.262173 (rank : 40)	θ value	0.00134147 (rank : 54)
Query Neighborhood Hits	120	Target Neighborhood Hits	91	Shared Neighborhood Hits	53
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CEND2_HUMAN
NC score	0.258878 (rank : 41)	θ value	1.69304e-06 (rank : 25)
Query Neighborhood Hits	120	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

SWP70_HUMAN
NC score	0.257300 (rank : 42)	θ value	1.69304e-06 (rank : 27)
Query Neighborhood Hits	120	Target Neighborhood Hits	973	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CENB5_HUMAN
NC score	0.251597 (rank : 43)	θ value	0.000158464 (rank : 45)
Query Neighborhood Hits	120	Target Neighborhood Hits	395	Shared Neighborhood Hits	66
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

SWP70_MOUSE
NC score	0.250858 (rank : 44)	θ value	1.29631e-06 (rank : 24)
Query Neighborhood Hits	120	Target Neighborhood Hits	1097	Shared Neighborhood Hits	77
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CENB1_HUMAN
NC score	0.245986 (rank : 45)	θ value	3.77169e-06 (rank : 31)
Query Neighborhood Hits	120	Target Neighborhood Hits	383	Shared Neighborhood Hits	61
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

PHLB1_MOUSE
NC score	0.243672 (rank : 46)	θ value	0.000461057 (rank : 49)
Query Neighborhood Hits	120	Target Neighborhood Hits	678	Shared Neighborhood Hits	55
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

CEND1_MOUSE
NC score	0.240113 (rank : 47)	θ value	9.29e-05 (rank : 44)
Query Neighborhood Hits	120	Target Neighborhood Hits	260	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

C43BP_HUMAN
NC score	0.238224 (rank : 48)	θ value	0.00869519 (rank : 68)
Query Neighborhood Hits	120	Target Neighborhood Hits	87	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

PSD3_HUMAN
NC score	0.237566 (rank : 49)	θ value	0.0431538 (rank : 74)
Query Neighborhood Hits	120	Target Neighborhood Hits	75	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

DGKH_HUMAN
NC score	0.219066 (rank : 50)	θ value	0.00228821 (rank : 58)
Query Neighborhood Hits	120	Target Neighborhood Hits	255	Shared Neighborhood Hits	68
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

CEND3_HUMAN
NC score	0.217885 (rank : 51)	θ value	0.000786445 (rank : 51)
Query Neighborhood Hits	120	Target Neighborhood Hits	275	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
NC score	0.216023 (rank : 52)	θ value	0.00102713 (rank : 52)
Query Neighborhood Hits	120	Target Neighborhood Hits	228	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

PKHB2_HUMAN
NC score	0.215146 (rank : 53)	θ value	0.0961366 (rank : 76)
Query Neighborhood Hits	120	Target Neighborhood Hits	54	Shared Neighborhood Hits	38
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

CENA1_HUMAN
NC score	0.213422 (rank : 54)	θ value	0.0193708 (rank : 69)
Query Neighborhood Hits	120	Target Neighborhood Hits	87	Shared Neighborhood Hits	49
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CENA2_HUMAN
NC score	0.212942 (rank : 55)	θ value	0.365318 (rank : 86)
Query Neighborhood Hits	120	Target Neighborhood Hits	83	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

PHLB2_MOUSE
NC score	0.210523 (rank : 56)	θ value	1.09739e-05 (rank : 36)
Query Neighborhood Hits	120	Target Neighborhood Hits	1016	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_HUMAN
NC score	0.208589 (rank : 57)	θ value	3.19293e-05 (rank : 39)
Query Neighborhood Hits	120	Target Neighborhood Hits	964	Shared Neighborhood Hits	58
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB1_HUMAN
NC score	0.202177 (rank : 58)	θ value	0.00228821 (rank : 59)
Query Neighborhood Hits	120	Target Neighborhood Hits	1038	Shared Neighborhood Hits	54
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

CNKR1_HUMAN
NC score	0.197512 (rank : 59)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	120	Target Neighborhood Hits	154	Shared Neighborhood Hits	49
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CENA2_MOUSE
NC score	0.179340 (rank : 60)	θ value	0.365318 (rank : 87)
Query Neighborhood Hits	120	Target Neighborhood Hits	68	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

DGKD_HUMAN
NC score	0.178890 (rank : 61)	θ value	0.00298849 (rank : 60)
Query Neighborhood Hits	120	Target Neighborhood Hits	231	Shared Neighborhood Hits	46
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

CNKR2_MOUSE
NC score	0.163122 (rank : 62)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	120	Target Neighborhood Hits	197	Shared Neighborhood Hits	50
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.162762 (rank : 63)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	120	Target Neighborhood Hits	197	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

TBCD2_HUMAN
NC score	0.152293 (rank : 64)	θ value	0.0330416 (rank : 72)
Query Neighborhood Hits	120	Target Neighborhood Hits	419	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

MYO10_HUMAN
NC score	0.151826 (rank : 65)	θ value	2.88788e-06 (rank : 30)
Query Neighborhood Hits	120	Target Neighborhood Hits	920	Shared Neighborhood Hits	91
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

MTMR5_HUMAN
NC score	0.149836 (rank : 66)	θ value	0.0193708 (rank : 70)
Query Neighborhood Hits	120	Target Neighborhood Hits	141	Shared Neighborhood Hits	49
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

MTMRD_HUMAN
NC score	0.147415 (rank : 67)	θ value	0.62314 (rank : 95)
Query Neighborhood Hits	120	Target Neighborhood Hits	135	Shared Neighborhood Hits	61
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

RASL1_MOUSE
NC score	0.143872 (rank : 68)	θ value	0.125558 (rank : 78)
Query Neighborhood Hits	120	Target Neighborhood Hits	148	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

PSD4_MOUSE
NC score	0.142621 (rank : 69)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	120	Target Neighborhood Hits	78	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

PSD4_HUMAN
NC score	0.139487 (rank : 70)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	120	Target Neighborhood Hits	178	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

RASL1_HUMAN
NC score	0.136217 (rank : 71)	θ value	0.0330416 (rank : 71)
Query Neighborhood Hits	120	Target Neighborhood Hits	142	Shared Neighborhood Hits	17
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

OSBL9_HUMAN
NC score	0.136054 (rank : 72)	θ value	0.21417 (rank : 83)
Query Neighborhood Hits	120	Target Neighborhood Hits	138	Shared Neighborhood Hits	50
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

GBF1_HUMAN
NC score	0.132768 (rank : 73)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	120	Target Neighborhood Hits	142	Shared Neighborhood Hits	9
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

BIG2_HUMAN
NC score	0.132628 (rank : 74)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	120	Target Neighborhood Hits	66	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

PKHB1_MOUSE
NC score	0.132384 (rank : 75)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	120	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB1_HUMAN
NC score	0.132280 (rank : 76)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	120	Target Neighborhood Hits	46	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

BIG1_HUMAN
NC score	0.130898 (rank : 77)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	120	Target Neighborhood Hits	76	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

DDFL1_HUMAN
NC score	0.128048 (rank : 78)	θ value	1.06291 (rank : 99)
Query Neighborhood Hits	120	Target Neighborhood Hits	353	Shared Neighborhood Hits	33
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

FARP2_MOUSE
NC score	0.125039 (rank : 79)	θ value	0.00134147 (rank : 55)
Query Neighborhood Hits	120	Target Neighborhood Hits	209	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

DDEF1_MOUSE
NC score	0.121625 (rank : 80)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	120	Target Neighborhood Hits	592	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

FBX8_MOUSE
NC score	0.121265 (rank : 81)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	120	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

MRIP_MOUSE
NC score	0.121034 (rank : 82)	θ value	0.47712 (rank : 91)
Query Neighborhood Hits	120	Target Neighborhood Hits	569	Shared Neighborhood Hits	58
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

FBX8_HUMAN
NC score	0.120767 (rank : 83)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	120	Target Neighborhood Hits	44	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

OSBP1_HUMAN
NC score	0.120634 (rank : 84)	θ value	1.38821 (rank : 101)
Query Neighborhood Hits	120	Target Neighborhood Hits	180	Shared Neighborhood Hits	56
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

IQEC3_HUMAN
NC score	0.119740 (rank : 85)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	120	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

FARP2_HUMAN
NC score	0.118184 (rank : 86)	θ value	0.00665767 (rank : 67)
Query Neighborhood Hits	120	Target Neighborhood Hits	240	Shared Neighborhood Hits	39
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

IQEC3_MOUSE
NC score	0.118136 (rank : 87)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	120	Target Neighborhood Hits	274	Shared Neighborhood Hits	11
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

MRIP_HUMAN
NC score	0.115843 (rank : 88)	θ value	1.81305 (rank : 103)
Query Neighborhood Hits	120	Target Neighborhood Hits	578	Shared Neighborhood Hits	58
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

IQEC1_HUMAN
NC score	0.115734 (rank : 89)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	120	Target Neighborhood Hits	76	Shared Neighborhood Hits	12
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC1_MOUSE
NC score	0.114590 (rank : 90)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	120	Target Neighborhood Hits	54	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

FARP1_HUMAN
NC score	0.113375 (rank : 91)	θ value	0.163984 (rank : 79)
Query Neighborhood Hits	120	Target Neighborhood Hits	241	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PKHA3_MOUSE
NC score	0.112241 (rank : 92)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	120	Target Neighborhood Hits	67	Shared Neighborhood Hits	37
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

DDFL1_MOUSE
NC score	0.111514 (rank : 93)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	120	Target Neighborhood Hits	324	Shared Neighborhood Hits	30
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

PKHA3_HUMAN
NC score	0.109361 (rank : 94)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	120	Target Neighborhood Hits	66	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

IQEC2_MOUSE
NC score	0.105688 (rank : 95)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	120	Target Neighborhood Hits	417	Shared Neighborhood Hits	15
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_HUMAN
NC score	0.105265 (rank : 96)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	120	Target Neighborhood Hits	403	Shared Neighborhood Hits	15
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

DGKK_HUMAN
NC score	0.104570 (rank : 97)	θ value	0.21417 (rank : 81)
Query Neighborhood Hits	120	Target Neighborhood Hits	378	Shared Neighborhood Hits	31
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

RASL2_HUMAN
NC score	0.103732 (rank : 98)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	120	Target Neighborhood Hits	161	Shared Neighborhood Hits	12
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

DDEF2_HUMAN
NC score	0.102823 (rank : 99)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	120	Target Neighborhood Hits	599	Shared Neighborhood Hits	38
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.100866 (rank : 100)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	120	Target Neighborhood Hits	625	Shared Neighborhood Hits	37
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

OSBP2_MOUSE
NC score	0.096406 (rank : 101)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	120	Target Neighborhood Hits	150	Shared Neighborhood Hits	46
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

SMP1L_HUMAN
NC score	0.095988 (rank : 102)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	120	Target Neighborhood Hits	74	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
NC score	0.095662 (rank : 103)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	120	Target Neighborhood Hits	70	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SMAP1_MOUSE
NC score	0.095517 (rank : 104)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	120	Target Neighborhood Hits	120	Shared Neighborhood Hits	16
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_HUMAN
NC score	0.094229 (rank : 105)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	120	Target Neighborhood Hits	98	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

AKT2_MOUSE
NC score	0.092588 (rank : 106)	θ value	3.41135e-07 (rank : 20)
Query Neighborhood Hits	120	Target Neighborhood Hits	875	Shared Neighborhood Hits	52
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

GNRP_MOUSE
NC score	0.092486 (rank : 107)	θ value	8.99809 (rank : 119)
Query Neighborhood Hits	120	Target Neighborhood Hits	191	Shared Neighborhood Hits	43
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

AKT2_HUMAN
NC score	0.091274 (rank : 108)	θ value	2.21117e-06 (rank : 28)
Query Neighborhood Hits	120	Target Neighborhood Hits	878	Shared Neighborhood Hits	53
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

GNRP_HUMAN
NC score	0.090051 (rank : 109)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	120	Target Neighborhood Hits	239	Shared Neighborhood Hits	42
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

OSBP2_HUMAN
NC score	0.089847 (rank : 110)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	120	Target Neighborhood Hits	154	Shared Neighborhood Hits	49
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

ARFG1_MOUSE
NC score	0.085055 (rank : 111)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	120	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG3_HUMAN
NC score	0.084570 (rank : 112)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	120	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

AKT1_HUMAN
NC score	0.084450 (rank : 113)	θ value	0.00020696 (rank : 46)
Query Neighborhood Hits	120	Target Neighborhood Hits	885	Shared Neighborhood Hits	56
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
NC score	0.083912 (rank : 114)	θ value	0.000602161 (rank : 50)
Query Neighborhood Hits	120	Target Neighborhood Hits	878	Shared Neighborhood Hits	55
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

ARFG3_MOUSE
NC score	0.083862 (rank : 115)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	120	Target Neighborhood Hits	80	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG1_HUMAN
NC score	0.082643 (rank : 116)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	120	Target Neighborhood Hits	60	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

DYN3_HUMAN
NC score	0.082547 (rank : 117)	θ value	0.813845 (rank : 96)
Query Neighborhood Hits	120	Target Neighborhood Hits	158	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

DYN2_MOUSE
NC score	0.082398 (rank : 118)	θ value	0.62314 (rank : 94)
Query Neighborhood Hits	120	Target Neighborhood Hits	104	Shared Neighborhood Hits	26
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

DYN2_HUMAN
NC score	0.082373 (rank : 119)	θ value	0.62314 (rank : 93)
Query Neighborhood Hits	120	Target Neighborhood Hits	112	Shared Neighborhood Hits	26
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

AKT3_HUMAN
NC score	0.081162 (rank : 120)	θ value	9.29e-05 (rank : 42)
Query Neighborhood Hits	120	Target Neighborhood Hits	872	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.081148 (rank : 121)	θ value	9.29e-05 (rank : 43)
Query Neighborhood Hits	120	Target Neighborhood Hits	872	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

ANLN_HUMAN
NC score	0.080132 (rank : 122)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	120	Target Neighborhood Hits	222	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

SYGP1_HUMAN
NC score	0.079985 (rank : 123)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	120	Target Neighborhood Hits	589	Shared Neighborhood Hits	19
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

DAB2P_MOUSE
NC score	0.077585 (rank : 124)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	120	Target Neighborhood Hits	284	Shared Neighborhood Hits	14
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

NGAP_HUMAN
NC score	0.077271 (rank : 125)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	120	Target Neighborhood Hits	517	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

TARA_MOUSE
NC score	0.077217 (rank : 126)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	120	Target Neighborhood Hits	1133	Shared Neighborhood Hits	58
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

DAB2P_HUMAN
NC score	0.077165 (rank : 127)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	120	Target Neighborhood Hits	303	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

CENG1_MOUSE
NC score	0.075735 (rank : 128)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	120	Target Neighborhood Hits	531	Shared Neighborhood Hits	27
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG1_HUMAN
NC score	0.074659 (rank : 129)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	120	Target Neighborhood Hits	544	Shared Neighborhood Hits	26
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG3_HUMAN
NC score	0.072458 (rank : 130)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	120	Target Neighborhood Hits	455	Shared Neighborhood Hits	22
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
NC score	0.072344 (rank : 131)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	120	Target Neighborhood Hits	467	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

OSB11_MOUSE
NC score	0.071507 (rank : 132)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	120	Target Neighborhood Hits	71	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

CHIN_HUMAN
NC score	0.070630 (rank : 133)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	120	Target Neighborhood Hits	227	Shared Neighborhood Hits	19
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
NC score	0.070154 (rank : 134)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	120	Target Neighborhood Hits	229	Shared Neighborhood Hits	19
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

OSB11_HUMAN
NC score	0.070046 (rank : 135)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	120	Target Neighborhood Hits	60	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

CHIO_HUMAN
NC score	0.067068 (rank : 136)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	120	Target Neighborhood Hits	220	Shared Neighborhood Hits	19
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

GIT1_HUMAN
NC score	0.066755 (rank : 137)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	120	Target Neighborhood Hits	336	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

OPHN1_MOUSE
NC score	0.066717 (rank : 138)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	120	Target Neighborhood Hits	174	Shared Neighborhood Hits	17
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

ANLN_MOUSE
NC score	0.066532 (rank : 139)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	120	Target Neighborhood Hits	297	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

GIT1_MOUSE
NC score	0.066100 (rank : 140)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	120	Target Neighborhood Hits	341	Shared Neighborhood Hits	21
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

RHG26_HUMAN
NC score	0.065908 (rank : 141)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	120	Target Neighborhood Hits	281	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

CENG2_HUMAN
NC score	0.065881 (rank : 142)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	120	Target Neighborhood Hits	471	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG2_MOUSE
NC score	0.065503 (rank : 143)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	120	Target Neighborhood Hits	463	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

OPHN1_HUMAN
NC score	0.065185 (rank : 144)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	120	Target Neighborhood Hits	161	Shared Neighborhood Hits	15
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RHG12_MOUSE
NC score	0.064735 (rank : 145)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	120	Target Neighborhood Hits	204	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

GIT2_HUMAN
NC score	0.063990 (rank : 146)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	120	Target Neighborhood Hits	381	Shared Neighborhood Hits	17
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

FGD6_MOUSE
NC score	0.063645 (rank : 147)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	120	Target Neighborhood Hits	282	Shared Neighborhood Hits	40
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

GIT2_MOUSE
NC score	0.063429 (rank : 148)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	120	Target Neighborhood Hits	323	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

OSBL3_HUMAN
NC score	0.062730 (rank : 149)	θ value	3.0926 (rank : 109)
Query Neighborhood Hits	120	Target Neighborhood Hits	93	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

ARBK1_HUMAN
NC score	0.061931 (rank : 150)	θ value	0.00228821 (rank : 56)
Query Neighborhood Hits	120	Target Neighborhood Hits	859	Shared Neighborhood Hits	32
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

NF1_MOUSE
NC score	0.061632 (rank : 151)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	120	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

ARBK1_MOUSE
NC score	0.061216 (rank : 152)	θ value	0.00228821 (rank : 57)
Query Neighborhood Hits	120	Target Neighborhood Hits	849	Shared Neighborhood Hits	31
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

NF1_HUMAN
NC score	0.061208 (rank : 153)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	120	Target Neighborhood Hits	56	Shared Neighborhood Hits	7
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

FGD6_HUMAN
NC score	0.061149 (rank : 154)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	120	Target Neighborhood Hits	237	Shared Neighborhood Hits	45
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

DOC10_HUMAN
NC score	0.060557 (rank : 155)	θ value	0.62314 (rank : 92)
Query Neighborhood Hits	120	Target Neighborhood Hits	88	Shared Neighborhood Hits	23
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

SPTN4_HUMAN
NC score	0.060333 (rank : 156)	θ value	0.00102713 (rank : 53)
Query Neighborhood Hits	120	Target Neighborhood Hits	570	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

CHIO_MOUSE
NC score	0.059831 (rank : 157)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	120	Target Neighborhood Hits	130	Shared Neighborhood Hits	16
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

TARA_HUMAN
NC score	0.058711 (rank : 158)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	120	Target Neighborhood Hits	1626	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

OSBL3_MOUSE
NC score	0.057452 (rank : 159)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	120	Target Neighborhood Hits	86	Shared Neighborhood Hits	36
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

RHG09_HUMAN
NC score	0.057180 (rank : 160)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	120	Target Neighborhood Hits	186	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

FGD5_HUMAN
NC score	0.057139 (rank : 161)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	120	Target Neighborhood Hits	235	Shared Neighborhood Hits	34
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

RGAP1_MOUSE
NC score	0.056797 (rank : 162)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	120	Target Neighborhood Hits	185	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

KPCD3_HUMAN
NC score	0.056644 (rank : 163)	θ value	0.00298849 (rank : 61)
Query Neighborhood Hits	120	Target Neighborhood Hits	895	Shared Neighborhood Hits	24
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

RHG12_HUMAN
NC score	0.056233 (rank : 164)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	120	Target Neighborhood Hits	190	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

KPCD3_MOUSE
NC score	0.056232 (rank : 165)	θ value	0.00509761 (rank : 65)
Query Neighborhood Hits	120	Target Neighborhood Hits	901	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

TEC_HUMAN
NC score	0.055953 (rank : 166)	θ value	0.0961366 (rank : 77)
Query Neighborhood Hits	120	Target Neighborhood Hits	1006	Shared Neighborhood Hits	46
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

KPCD1_HUMAN
NC score	0.055812 (rank : 167)	θ value	0.00509761 (rank : 64)
Query Neighborhood Hits	120	Target Neighborhood Hits	901	Shared Neighborhood Hits	26
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

NUPL_HUMAN
NC score	0.055573 (rank : 168)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	120	Target Neighborhood Hits	68	Shared Neighborhood Hits	16
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

DOCK9_MOUSE
NC score	0.055316 (rank : 169)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	120	Target Neighborhood Hits	79	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

BMX_HUMAN
NC score	0.055315 (rank : 170)	θ value	0.279714 (rank : 84)
Query Neighborhood Hits	120	Target Neighborhood Hits	942	Shared Neighborhood Hits	55
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

IRS1_HUMAN
NC score	0.055292 (rank : 171)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	120	Target Neighborhood Hits	109	Shared Neighborhood Hits	16
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

NUPL_MOUSE
NC score	0.054826 (rank : 172)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	120	Target Neighborhood Hits	113	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

RBP1_HUMAN
NC score	0.054383 (rank : 173)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	120	Target Neighborhood Hits	521	Shared Neighborhood Hits	17
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

K1688_MOUSE
NC score	0.054349 (rank : 174)	θ value	2.36792 (rank : 107)
Query Neighborhood Hits	120	Target Neighborhood Hits	188	Shared Neighborhood Hits	11
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

DOCK9_HUMAN
NC score	0.054163 (rank : 175)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	120	Target Neighborhood Hits	82	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

FGD5_MOUSE
NC score	0.053247 (rank : 176)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	120	Target Neighborhood Hits	170	Shared Neighborhood Hits	28
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

TEC_MOUSE
NC score	0.053203 (rank : 177)	θ value	0.0330416 (rank : 73)
Query Neighborhood Hits	120	Target Neighborhood Hits	1006	Shared Neighborhood Hits	47
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

RGAP1_HUMAN
NC score	0.053035 (rank : 178)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	120	Target Neighborhood Hits	189	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RBP1_MOUSE
NC score	0.052955 (rank : 179)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	120	Target Neighborhood Hits	493	Shared Neighborhood Hits	16
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

K1688_HUMAN
NC score	0.052915 (rank : 180)	θ value	2.36792 (rank : 106)
Query Neighborhood Hits	120	Target Neighborhood Hits	217	Shared Neighborhood Hits	10
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

KPCD1_MOUSE
NC score	0.052902 (rank : 181)	θ value	0.0961366 (rank : 75)
Query Neighborhood Hits	120	Target Neighborhood Hits	891	Shared Neighborhood Hits	24
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

ARBK2_HUMAN
NC score	0.052581 (rank : 182)	θ value	1.81305 (rank : 102)
Query Neighborhood Hits	120	Target Neighborhood Hits	849	Shared Neighborhood Hits	26
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

BMX_MOUSE
NC score	0.052278 (rank : 183)	θ value	0.365318 (rank : 85)
Query Neighborhood Hits	120	Target Neighborhood Hits	912	Shared Neighborhood Hits	52
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

OSB10_HUMAN
NC score	0.051728 (rank : 184)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	120	Target Neighborhood Hits	55	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

ABR_HUMAN
NC score	0.051419 (rank : 185)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	120	Target Neighborhood Hits	166	Shared Neighborhood Hits	14
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

GMIP_MOUSE
NC score	0.051262 (rank : 186)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	120	Target Neighborhood Hits	202	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

KPCD2_HUMAN
NC score	0.050883 (rank : 187)	θ value	0.21417 (rank : 82)
Query Neighborhood Hits	120	Target Neighborhood Hits	910	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

FGD4_MOUSE
NC score	0.050872 (rank : 188)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	120	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

HRBL_HUMAN
NC score	0.050538 (rank : 189)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	120	Target Neighborhood Hits	179	Shared Neighborhood Hits	16
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

BCR_HUMAN
NC score	0.050159 (rank : 190)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	120	Target Neighborhood Hits	204	Shared Neighborhood Hits	15
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

DYN1_HUMAN
NC score	0.050073 (rank : 191)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	120	Target Neighborhood Hits	216	Shared Neighborhood Hits	21
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

IRS1_MOUSE
NC score	0.047663 (rank : 192)	θ value	8.99809 (rank : 120)
Query Neighborhood Hits	120	Target Neighborhood Hits	112	Shared Neighborhood Hits	14
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

KIF1A_MOUSE
NC score	0.041328 (rank : 193)	θ value	0.47712 (rank : 90)
Query Neighborhood Hits	120	Target Neighborhood Hits	239	Shared Neighborhood Hits	16
SwissProt Accessions	P33173, Q61770	Gene names	Kif1a, Atsv, Kif1
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

SPTB2_HUMAN
NC score	0.038967 (rank : 194)	θ value	3.0926 (rank : 110)
Query Neighborhood Hits	120	Target Neighborhood Hits	748	Shared Neighborhood Hits	27
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

KIF1B_HUMAN
NC score	0.038544 (rank : 195)	θ value	0.813845 (rank : 97)
Query Neighborhood Hits	120	Target Neighborhood Hits	178	Shared Neighborhood Hits	15
SwissProt Accessions	O60333, Q96Q94, Q9BV80, Q9P280	Gene names	KIF1B, KIAA0591, KIAA1448
Domain Architecture
Description	Kinesin-like protein KIF1B (Klp).

KIF1A_HUMAN
NC score	0.038377 (rank : 196)	θ value	0.47712 (rank : 89)
Query Neighborhood Hits	120	Target Neighborhood Hits	240	Shared Neighborhood Hits	14
SwissProt Accessions	Q12756	Gene names	KIF1A, ATSV
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

SPTB2_MOUSE
NC score	0.037526 (rank : 197)	θ value	1.81305 (rank : 104)
Query Neighborhood Hits	120	Target Neighborhood Hits	770	Shared Neighborhood Hits	29
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

KIF1B_MOUSE
NC score	0.037375 (rank : 198)	θ value	0.813845 (rank : 98)
Query Neighborhood Hits	120	Target Neighborhood Hits	167	Shared Neighborhood Hits	16
SwissProt Accessions	Q60575, Q9R0B4, Q9WVE5, Q9Z119	Gene names	Kif1b
Domain Architecture
Description	Kinesin-like protein KIF1B.

ARHG7_HUMAN
NC score	0.034722 (rank : 199)	θ value	2.36792 (rank : 105)
Query Neighborhood Hits	120	Target Neighborhood Hits	347	Shared Neighborhood Hits	15
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CCD21_HUMAN
NC score	0.019778 (rank : 200)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	120	Target Neighborhood Hits	1228	Shared Neighborhood Hits	18
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

SNTA1_MOUSE
NC score	0.015519 (rank : 201)	θ value	1.06291 (rank : 100)
Query Neighborhood Hits	120	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SNTA1_HUMAN
NC score	0.013673 (rank : 202)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	120	Target Neighborhood Hits	186	Shared Neighborhood Hits	5
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

ESR2_HUMAN
NC score	0.003703 (rank : 203)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	120	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q92731, O60608, O60685, O60702, O60703, O75583, O75584, Q86Z31, Q9UEV6, Q9UHD3, Q9UQK9	Gene names	ESR2, ESTRB, NR3A2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).