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Network neighborhood for query Sequence : NF1_HUMAN

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NF1_HUMAN
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NF1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	56	Target Neighborhood Hits	56	Shared Neighborhood Hits	56
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

NF1_MOUSE
θ value	0 (rank : 2)	NC score	0.998950 (rank : 2)
Query Neighborhood Hits	56	Target Neighborhood Hits	62	Shared Neighborhood Hits	52
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

DAB2P_MOUSE
θ value	3.39556e-23 (rank : 3)	NC score	0.592489 (rank : 3)
Query Neighborhood Hits	56	Target Neighborhood Hits	284	Shared Neighborhood Hits	19
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

DAB2P_HUMAN
θ value	4.43474e-23 (rank : 4)	NC score	0.591870 (rank : 4)
Query Neighborhood Hits	56	Target Neighborhood Hits	303	Shared Neighborhood Hits	19
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

RASA1_HUMAN
θ value	1.6852e-22 (rank : 5)	NC score	0.477324 (rank : 11)
Query Neighborhood Hits	56	Target Neighborhood Hits	258	Shared Neighborhood Hits	18
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

NGAP_HUMAN
θ value	3.75424e-22 (rank : 6)	NC score	0.556901 (rank : 5)
Query Neighborhood Hits	56	Target Neighborhood Hits	517	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

RASA3_HUMAN
θ value	2.06002e-20 (rank : 7)	NC score	0.508070 (rank : 8)
Query Neighborhood Hits	56	Target Neighborhood Hits	166	Shared Neighborhood Hits	18
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

SYGP1_HUMAN
θ value	2.5182e-18 (rank : 8)	NC score	0.521213 (rank : 6)
Query Neighborhood Hits	56	Target Neighborhood Hits	589	Shared Neighborhood Hits	20
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

RASA3_MOUSE
θ value	2.13179e-17 (rank : 9)	NC score	0.510647 (rank : 7)
Query Neighborhood Hits	56	Target Neighborhood Hits	144	Shared Neighborhood Hits	16
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RASA2_HUMAN
θ value	2.7842e-17 (rank : 10)	NC score	0.495659 (rank : 9)
Query Neighborhood Hits	56	Target Neighborhood Hits	157	Shared Neighborhood Hits	18
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA2_MOUSE
θ value	2.35696e-16 (rank : 11)	NC score	0.483365 (rank : 10)
Query Neighborhood Hits	56	Target Neighborhood Hits	159	Shared Neighborhood Hits	16
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASL1_HUMAN
θ value	5.43371e-13 (rank : 12)	NC score	0.443546 (rank : 13)
Query Neighborhood Hits	56	Target Neighborhood Hits	142	Shared Neighborhood Hits	18
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
θ value	1.2105e-12 (rank : 13)	NC score	0.455162 (rank : 12)
Query Neighborhood Hits	56	Target Neighborhood Hits	148	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL2_HUMAN
θ value	3.52202e-12 (rank : 14)	NC score	0.407250 (rank : 14)
Query Neighborhood Hits	56	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

IQGA1_MOUSE
θ value	2.98157e-11 (rank : 15)	NC score	0.357322 (rank : 16)
Query Neighborhood Hits	56	Target Neighborhood Hits	219	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JKF1	Gene names	Iqgap1
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1.

IQGA2_HUMAN
θ value	5.08577e-11 (rank : 16)	NC score	0.383320 (rank : 15)
Query Neighborhood Hits	56	Target Neighborhood Hits	200	Shared Neighborhood Hits	18
SwissProt Accessions	Q13576	Gene names	IQGAP2
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP2.

IQGA1_HUMAN
θ value	1.133e-10 (rank : 17)	NC score	0.346858 (rank : 17)
Query Neighborhood Hits	56	Target Neighborhood Hits	250	Shared Neighborhood Hits	17
SwissProt Accessions	P46940	Gene names	IQGAP1, KIAA0051
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1 (p195).

IQGA3_HUMAN
θ value	1.06045e-08 (rank : 18)	NC score	0.342416 (rank : 18)
Query Neighborhood Hits	56	Target Neighborhood Hits	125	Shared Neighborhood Hits	18
SwissProt Accessions	Q86VI3	Gene names	IQGAP3
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP3.

RHG08_MOUSE
θ value	0.0193708 (rank : 19)	NC score	0.052934 (rank : 24)
Query Neighborhood Hits	56	Target Neighborhood Hits	73	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

ABCAD_HUMAN
θ value	0.47712 (rank : 20)	NC score	0.021618 (rank : 42)
Query Neighborhood Hits	56	Target Neighborhood Hits	207	Shared Neighborhood Hits	3
SwissProt Accessions	Q86UQ4, Q6ZTT7, Q86WI2, Q8N248	Gene names	ABCA13
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 13.

PDE4C_MOUSE
θ value	0.47712 (rank : 21)	NC score	0.025729 (rank : 36)
Query Neighborhood Hits	56	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

MDN1_HUMAN
θ value	0.813845 (rank : 22)	NC score	0.037935 (rank : 33)
Query Neighborhood Hits	56	Target Neighborhood Hits	662	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

RTP3_MOUSE
θ value	0.813845 (rank : 23)	NC score	0.023997 (rank : 39)
Query Neighborhood Hits	56	Target Neighborhood Hits	374	Shared Neighborhood Hits	3
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

TENS1_HUMAN
θ value	0.813845 (rank : 24)	NC score	0.022825 (rank : 40)
Query Neighborhood Hits	56	Target Neighborhood Hits	400	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

PHLPP_HUMAN
θ value	1.38821 (rank : 25)	NC score	0.019903 (rank : 43)
Query Neighborhood Hits	56	Target Neighborhood Hits	604	Shared Neighborhood Hits	6
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

C8AP2_HUMAN
θ value	1.81305 (rank : 26)	NC score	0.031715 (rank : 35)
Query Neighborhood Hits	56	Target Neighborhood Hits	548	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

ECE1_HUMAN
θ value	1.81305 (rank : 27)	NC score	0.025425 (rank : 37)
Query Neighborhood Hits	56	Target Neighborhood Hits	27	Shared Neighborhood Hits	5
SwissProt Accessions	P42892, Q14217, Q58GE7, Q5THM5, Q5THM7, Q5THM8, Q9UJQ6, Q9UPF4, Q9UPM4, Q9Y501	Gene names	ECE1
Domain Architecture
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

K0133_HUMAN
θ value	1.81305 (rank : 28)	NC score	0.049105 (rank : 29)
Query Neighborhood Hits	56	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q14146	Gene names	KIAA0133
Domain Architecture	No domain graphic available
Description	Protein KIAA0133.

MYO15_HUMAN
θ value	1.81305 (rank : 29)	NC score	0.013123 (rank : 57)
Query Neighborhood Hits	56	Target Neighborhood Hits	671	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PHLPP_MOUSE
θ value	1.81305 (rank : 30)	NC score	0.019470 (rank : 44)
Query Neighborhood Hits	56	Target Neighborhood Hits	394	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

ARMC6_HUMAN
θ value	2.36792 (rank : 31)	NC score	0.039076 (rank : 32)
Query Neighborhood Hits	56	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q6NXE6, O94999, Q9BTH5	Gene names	ARMC6
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 6.

PDE4C_HUMAN
θ value	2.36792 (rank : 32)	NC score	0.019054 (rank : 45)
Query Neighborhood Hits	56	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

ZN343_HUMAN
θ value	2.36792 (rank : 33)	NC score	-0.000407 (rank : 65)
Query Neighborhood Hits	56	Target Neighborhood Hits	768	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P1L6, Q5JXU8, Q5JXU9, Q8N8F2, Q96EX8, Q96NA5, Q9BQB0	Gene names	ZNF343
Domain Architecture	No domain graphic available
Description	Zinc finger protein 343.

ARPC2_HUMAN
θ value	3.0926 (rank : 34)	NC score	0.046150 (rank : 30)
Query Neighborhood Hits	56	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	O15144, Q92801, Q9P1D4	Gene names	ARPC2, ARC34
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 2 (ARP2/3 complex 34 kDa subunit) (p34-ARC).

MMEL1_MOUSE
θ value	3.0926 (rank : 35)	NC score	0.021961 (rank : 41)
Query Neighborhood Hits	56	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JLI3, Q3U495, Q9ERK2, Q9ERK3, Q9QZV6, Q9QZV7	Gene names	Mmel1, Nep2, Nl1, Sep
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) (Neprilysin-like peptidase) (NEPLP) (Neprilysin-like 1) (NL-1) (Soluble secreted endopeptidase) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

NELFB_MOUSE
θ value	3.0926 (rank : 36)	NC score	0.034135 (rank : 34)
Query Neighborhood Hits	56	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C4Y3, Q99J41, Q9JJA5	Gene names	Nelfb
Domain Architecture
Description	Negative elongation factor B (NELF-B).

SDCG8_HUMAN
θ value	3.0926 (rank : 37)	NC score	0.014183 (rank : 54)
Query Neighborhood Hits	56	Target Neighborhood Hits	1002	Shared Neighborhood Hits	7
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

TLR5_MOUSE
θ value	3.0926 (rank : 38)	NC score	0.012513 (rank : 58)
Query Neighborhood Hits	56	Target Neighborhood Hits	287	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JLF7	Gene names	Tlr5
Domain Architecture
Description	Toll-like receptor 5 precursor.

ARPC2_MOUSE
θ value	4.03905 (rank : 39)	NC score	0.042663 (rank : 31)
Query Neighborhood Hits	56	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CVB6, Q3U870	Gene names	Arpc2
Domain Architecture	No domain graphic available
Description	Actin-related protein 2/3 complex subunit 2 (ARP2/3 complex 34 kDa subunit) (p34-ARC).

DMXL1_MOUSE
θ value	4.03905 (rank : 40)	NC score	0.017478 (rank : 46)
Query Neighborhood Hits	56	Target Neighborhood Hits	257	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PNC0, Q3TLG8, Q6PHM6, Q8BQF2	Gene names	Dmxl1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

AMPE_HUMAN
θ value	5.27518 (rank : 41)	NC score	0.014488 (rank : 53)
Query Neighborhood Hits	56	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q07075	Gene names	ENPEP
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (Differentiation antigen gp160) (CD249 antigen).

CP39A_HUMAN
θ value	5.27518 (rank : 42)	NC score	0.012512 (rank : 59)
Query Neighborhood Hits	56	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYL5, Q96FW5	Gene names	CYP39A1
Domain Architecture
Description	Cytochrome P450 39A1 (EC 1.14.13.99) (24-hydroxycholesterol 7-alpha- hydroxylase) (Oxysterol 7-alpha-hydroxylase) (hCYP39A1).

TIM_MOUSE
θ value	5.27518 (rank : 43)	NC score	0.024347 (rank : 38)
Query Neighborhood Hits	56	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1X4, Q63ZX9, Q6P204, Q6PDL4, Q7TPV8, Q8R0Q2, Q9R268, Q9Z0E7	Gene names	Timeless, Tim1, Timeless1
Domain Architecture	No domain graphic available
Description	Timeless homolog (mTim).

AMPE_MOUSE
θ value	6.88961 (rank : 44)	NC score	0.013254 (rank : 56)
Query Neighborhood Hits	56	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	P16406	Gene names	Enpep
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (BP-1/6C3 antigen).

AP2B1_HUMAN
θ value	6.88961 (rank : 45)	NC score	0.015840 (rank : 49)
Query Neighborhood Hits	56	Target Neighborhood Hits	59	Shared Neighborhood Hits	5
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_MOUSE
θ value	6.88961 (rank : 46)	NC score	0.015842 (rank : 48)
Query Neighborhood Hits	56	Target Neighborhood Hits	58	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

RAI1_MOUSE
θ value	6.88961 (rank : 47)	NC score	0.014560 (rank : 52)
Query Neighborhood Hits	56	Target Neighborhood Hits	344	Shared Neighborhood Hits	5
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

AP1B1_MOUSE
θ value	8.99809 (rank : 48)	NC score	0.014138 (rank : 55)
Query Neighborhood Hits	56	Target Neighborhood Hits	59	Shared Neighborhood Hits	5
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

CAND1_HUMAN
θ value	8.99809 (rank : 49)	NC score	0.014742 (rank : 51)
Query Neighborhood Hits	56	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q86VP6, O94918, Q6PIY4, Q8NDJ4, Q96JZ9, Q96T19, Q9BTC4, Q9H0G2, Q9P0H7, Q9UF85	Gene names	CAND1, KIAA0829, TIP120, TIP120A
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1) (TBP-interacting protein TIP120A) (TBP-interacting protein of 120 kDa A).

CAND1_MOUSE
θ value	8.99809 (rank : 50)	NC score	0.014769 (rank : 50)
Query Neighborhood Hits	56	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZQ38, Q6PFR0, Q9CV45	Gene names	Cand1, D10Ertd516e, Kiaa0829
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1).

ECE1_MOUSE
θ value	8.99809 (rank : 51)	NC score	0.017060 (rank : 47)
Query Neighborhood Hits	56	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

FA47A_HUMAN
θ value	8.99809 (rank : 52)	NC score	0.012261 (rank : 60)
Query Neighborhood Hits	56	Target Neighborhood Hits	451	Shared Neighborhood Hits	4
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

GCC2_MOUSE
θ value	8.99809 (rank : 53)	NC score	0.008717 (rank : 62)
Query Neighborhood Hits	56	Target Neighborhood Hits	1619	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

K1HA_HUMAN
θ value	8.99809 (rank : 54)	NC score	0.001308 (rank : 64)
Query Neighborhood Hits	56	Target Neighborhood Hits	502	Shared Neighborhood Hits	4
SwissProt Accessions	O76009	Gene names	KRTHA3A, HHA3-I, HKA3A
Domain Architecture
Description	Keratin, type I cuticular Ha3-I (Hair keratin, type I Ha3-I).

KCTD3_MOUSE
θ value	8.99809 (rank : 55)	NC score	0.007389 (rank : 63)
Query Neighborhood Hits	56	Target Neighborhood Hits	85	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BFX3, Q6P7X4	Gene names	Kctd3
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD3.

TOP2B_MOUSE
θ value	8.99809 (rank : 56)	NC score	0.010542 (rank : 61)
Query Neighborhood Hits	56	Target Neighborhood Hits	80	Shared Neighborhood Hits	3
SwissProt Accessions	Q64511, Q7TQG4	Gene names	Top2b
Domain Architecture
Description	DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme).

FA62A_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.059557 (rank : 22)
Query Neighborhood Hits	56	Target Neighborhood Hits	168	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.067222 (rank : 19)
Query Neighborhood Hits	56	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

PKHA1_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.059174 (rank : 23)
Query Neighborhood Hits	56	Target Neighborhood Hits	127	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.061208 (rank : 21)
Query Neighborhood Hits	56	Target Neighborhood Hits	120	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.052021 (rank : 25)
Query Neighborhood Hits	56	Target Neighborhood Hits	116	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

RFIP2_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.063619 (rank : 20)
Query Neighborhood Hits	56	Target Neighborhood Hits	97	Shared Neighborhood Hits	7
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

SYT3_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.050234 (rank : 28)
Query Neighborhood Hits	56	Target Neighborhood Hits	145	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.050465 (rank : 27)
Query Neighborhood Hits	56	Target Neighborhood Hits	147	Shared Neighborhood Hits	7
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT7_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.051936 (rank : 26)
Query Neighborhood Hits	56	Target Neighborhood Hits	137	Shared Neighborhood Hits	10
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

Hits sorted by NC score

NF1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	56	Target Neighborhood Hits	56	Shared Neighborhood Hits	56
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

NF1_MOUSE
NC score	0.998950 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	56	Target Neighborhood Hits	62	Shared Neighborhood Hits	52
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

DAB2P_MOUSE
NC score	0.592489 (rank : 3)	θ value	3.39556e-23 (rank : 3)
Query Neighborhood Hits	56	Target Neighborhood Hits	284	Shared Neighborhood Hits	19
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

DAB2P_HUMAN
NC score	0.591870 (rank : 4)	θ value	4.43474e-23 (rank : 4)
Query Neighborhood Hits	56	Target Neighborhood Hits	303	Shared Neighborhood Hits	19
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

NGAP_HUMAN
NC score	0.556901 (rank : 5)	θ value	3.75424e-22 (rank : 6)
Query Neighborhood Hits	56	Target Neighborhood Hits	517	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

SYGP1_HUMAN
NC score	0.521213 (rank : 6)	θ value	2.5182e-18 (rank : 8)
Query Neighborhood Hits	56	Target Neighborhood Hits	589	Shared Neighborhood Hits	20
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

RASA3_MOUSE
NC score	0.510647 (rank : 7)	θ value	2.13179e-17 (rank : 9)
Query Neighborhood Hits	56	Target Neighborhood Hits	144	Shared Neighborhood Hits	16
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RASA3_HUMAN
NC score	0.508070 (rank : 8)	θ value	2.06002e-20 (rank : 7)
Query Neighborhood Hits	56	Target Neighborhood Hits	166	Shared Neighborhood Hits	18
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASA2_HUMAN
NC score	0.495659 (rank : 9)	θ value	2.7842e-17 (rank : 10)
Query Neighborhood Hits	56	Target Neighborhood Hits	157	Shared Neighborhood Hits	18
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA2_MOUSE
NC score	0.483365 (rank : 10)	θ value	2.35696e-16 (rank : 11)
Query Neighborhood Hits	56	Target Neighborhood Hits	159	Shared Neighborhood Hits	16
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA1_HUMAN
NC score	0.477324 (rank : 11)	θ value	1.6852e-22 (rank : 5)
Query Neighborhood Hits	56	Target Neighborhood Hits	258	Shared Neighborhood Hits	18
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASL1_MOUSE
NC score	0.455162 (rank : 12)	θ value	1.2105e-12 (rank : 13)
Query Neighborhood Hits	56	Target Neighborhood Hits	148	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_HUMAN
NC score	0.443546 (rank : 13)	θ value	5.43371e-13 (rank : 12)
Query Neighborhood Hits	56	Target Neighborhood Hits	142	Shared Neighborhood Hits	18
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL2_HUMAN
NC score	0.407250 (rank : 14)	θ value	3.52202e-12 (rank : 14)
Query Neighborhood Hits	56	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

IQGA2_HUMAN
NC score	0.383320 (rank : 15)	θ value	5.08577e-11 (rank : 16)
Query Neighborhood Hits	56	Target Neighborhood Hits	200	Shared Neighborhood Hits	18
SwissProt Accessions	Q13576	Gene names	IQGAP2
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP2.

IQGA1_MOUSE
NC score	0.357322 (rank : 16)	θ value	2.98157e-11 (rank : 15)
Query Neighborhood Hits	56	Target Neighborhood Hits	219	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JKF1	Gene names	Iqgap1
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1.

IQGA1_HUMAN
NC score	0.346858 (rank : 17)	θ value	1.133e-10 (rank : 17)
Query Neighborhood Hits	56	Target Neighborhood Hits	250	Shared Neighborhood Hits	17
SwissProt Accessions	P46940	Gene names	IQGAP1, KIAA0051
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1 (p195).

IQGA3_HUMAN
NC score	0.342416 (rank : 18)	θ value	1.06045e-08 (rank : 18)
Query Neighborhood Hits	56	Target Neighborhood Hits	125	Shared Neighborhood Hits	18
SwissProt Accessions	Q86VI3	Gene names	IQGAP3
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP3.

FA62A_MOUSE
NC score	0.067222 (rank : 19)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	56	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RFIP2_HUMAN
NC score	0.063619 (rank : 20)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	56	Target Neighborhood Hits	97	Shared Neighborhood Hits	7
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

PKHA1_MOUSE
NC score	0.061208 (rank : 21)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	56	Target Neighborhood Hits	120	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

FA62A_HUMAN
NC score	0.059557 (rank : 22)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	56	Target Neighborhood Hits	168	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

PKHA1_HUMAN
NC score	0.059174 (rank : 23)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	56	Target Neighborhood Hits	127	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

RHG08_MOUSE
NC score	0.052934 (rank : 24)	θ value	0.0193708 (rank : 19)
Query Neighborhood Hits	56	Target Neighborhood Hits	73	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

PKHA2_MOUSE
NC score	0.052021 (rank : 25)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	56	Target Neighborhood Hits	116	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

SYT7_HUMAN
NC score	0.051936 (rank : 26)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	56	Target Neighborhood Hits	137	Shared Neighborhood Hits	10
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT3_MOUSE
NC score	0.050465 (rank : 27)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	56	Target Neighborhood Hits	147	Shared Neighborhood Hits	7
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_HUMAN
NC score	0.050234 (rank : 28)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	56	Target Neighborhood Hits	145	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

K0133_HUMAN
NC score	0.049105 (rank : 29)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	56	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q14146	Gene names	KIAA0133
Domain Architecture	No domain graphic available
Description	Protein KIAA0133.

ARPC2_HUMAN
NC score	0.046150 (rank : 30)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	56	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	O15144, Q92801, Q9P1D4	Gene names	ARPC2, ARC34
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 2 (ARP2/3 complex 34 kDa subunit) (p34-ARC).

ARPC2_MOUSE
NC score	0.042663 (rank : 31)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	56	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CVB6, Q3U870	Gene names	Arpc2
Domain Architecture	No domain graphic available
Description	Actin-related protein 2/3 complex subunit 2 (ARP2/3 complex 34 kDa subunit) (p34-ARC).

ARMC6_HUMAN
NC score	0.039076 (rank : 32)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	56	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q6NXE6, O94999, Q9BTH5	Gene names	ARMC6
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 6.

MDN1_HUMAN
NC score	0.037935 (rank : 33)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	56	Target Neighborhood Hits	662	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

NELFB_MOUSE
NC score	0.034135 (rank : 34)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	56	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C4Y3, Q99J41, Q9JJA5	Gene names	Nelfb
Domain Architecture
Description	Negative elongation factor B (NELF-B).

C8AP2_HUMAN
NC score	0.031715 (rank : 35)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	56	Target Neighborhood Hits	548	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

PDE4C_MOUSE
NC score	0.025729 (rank : 36)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	56	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

ECE1_HUMAN
NC score	0.025425 (rank : 37)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	56	Target Neighborhood Hits	27	Shared Neighborhood Hits	5
SwissProt Accessions	P42892, Q14217, Q58GE7, Q5THM5, Q5THM7, Q5THM8, Q9UJQ6, Q9UPF4, Q9UPM4, Q9Y501	Gene names	ECE1
Domain Architecture
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

TIM_MOUSE
NC score	0.024347 (rank : 38)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	56	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1X4, Q63ZX9, Q6P204, Q6PDL4, Q7TPV8, Q8R0Q2, Q9R268, Q9Z0E7	Gene names	Timeless, Tim1, Timeless1
Domain Architecture	No domain graphic available
Description	Timeless homolog (mTim).

RTP3_MOUSE
NC score	0.023997 (rank : 39)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	56	Target Neighborhood Hits	374	Shared Neighborhood Hits	3
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

TENS1_HUMAN
NC score	0.022825 (rank : 40)	θ value	0.813845 (rank : 24)
Query Neighborhood Hits	56	Target Neighborhood Hits	400	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

MMEL1_MOUSE
NC score	0.021961 (rank : 41)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	56	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JLI3, Q3U495, Q9ERK2, Q9ERK3, Q9QZV6, Q9QZV7	Gene names	Mmel1, Nep2, Nl1, Sep
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) (Neprilysin-like peptidase) (NEPLP) (Neprilysin-like 1) (NL-1) (Soluble secreted endopeptidase) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

ABCAD_HUMAN
NC score	0.021618 (rank : 42)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	56	Target Neighborhood Hits	207	Shared Neighborhood Hits	3
SwissProt Accessions	Q86UQ4, Q6ZTT7, Q86WI2, Q8N248	Gene names	ABCA13
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 13.

PHLPP_HUMAN
NC score	0.019903 (rank : 43)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	56	Target Neighborhood Hits	604	Shared Neighborhood Hits	6
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

PHLPP_MOUSE
NC score	0.019470 (rank : 44)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	56	Target Neighborhood Hits	394	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

PDE4C_HUMAN
NC score	0.019054 (rank : 45)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	56	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

DMXL1_MOUSE
NC score	0.017478 (rank : 46)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	56	Target Neighborhood Hits	257	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PNC0, Q3TLG8, Q6PHM6, Q8BQF2	Gene names	Dmxl1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

ECE1_MOUSE
NC score	0.017060 (rank : 47)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	56	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

AP2B1_MOUSE
NC score	0.015842 (rank : 48)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	56	Target Neighborhood Hits	58	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_HUMAN
NC score	0.015840 (rank : 49)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	56	Target Neighborhood Hits	59	Shared Neighborhood Hits	5
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

CAND1_MOUSE
NC score	0.014769 (rank : 50)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	56	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZQ38, Q6PFR0, Q9CV45	Gene names	Cand1, D10Ertd516e, Kiaa0829
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1).

CAND1_HUMAN
NC score	0.014742 (rank : 51)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	56	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q86VP6, O94918, Q6PIY4, Q8NDJ4, Q96JZ9, Q96T19, Q9BTC4, Q9H0G2, Q9P0H7, Q9UF85	Gene names	CAND1, KIAA0829, TIP120, TIP120A
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1) (TBP-interacting protein TIP120A) (TBP-interacting protein of 120 kDa A).

RAI1_MOUSE
NC score	0.014560 (rank : 52)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	56	Target Neighborhood Hits	344	Shared Neighborhood Hits	5
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

AMPE_HUMAN
NC score	0.014488 (rank : 53)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	56	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q07075	Gene names	ENPEP
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (Differentiation antigen gp160) (CD249 antigen).

SDCG8_HUMAN
NC score	0.014183 (rank : 54)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	56	Target Neighborhood Hits	1002	Shared Neighborhood Hits	7
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

AP1B1_MOUSE
NC score	0.014138 (rank : 55)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	56	Target Neighborhood Hits	59	Shared Neighborhood Hits	5
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AMPE_MOUSE
NC score	0.013254 (rank : 56)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	56	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	P16406	Gene names	Enpep
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (BP-1/6C3 antigen).

MYO15_HUMAN
NC score	0.013123 (rank : 57)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	56	Target Neighborhood Hits	671	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

TLR5_MOUSE
NC score	0.012513 (rank : 58)	θ value	3.0926 (rank : 38)
Query Neighborhood Hits	56	Target Neighborhood Hits	287	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JLF7	Gene names	Tlr5
Domain Architecture
Description	Toll-like receptor 5 precursor.

CP39A_HUMAN
NC score	0.012512 (rank : 59)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	56	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYL5, Q96FW5	Gene names	CYP39A1
Domain Architecture
Description	Cytochrome P450 39A1 (EC 1.14.13.99) (24-hydroxycholesterol 7-alpha- hydroxylase) (Oxysterol 7-alpha-hydroxylase) (hCYP39A1).

FA47A_HUMAN
NC score	0.012261 (rank : 60)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	56	Target Neighborhood Hits	451	Shared Neighborhood Hits	4
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

TOP2B_MOUSE
NC score	0.010542 (rank : 61)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	56	Target Neighborhood Hits	80	Shared Neighborhood Hits	3
SwissProt Accessions	Q64511, Q7TQG4	Gene names	Top2b
Domain Architecture
Description	DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme).

GCC2_MOUSE
NC score	0.008717 (rank : 62)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	56	Target Neighborhood Hits	1619	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

KCTD3_MOUSE
NC score	0.007389 (rank : 63)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	56	Target Neighborhood Hits	85	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BFX3, Q6P7X4	Gene names	Kctd3
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD3.

K1HA_HUMAN
NC score	0.001308 (rank : 64)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	56	Target Neighborhood Hits	502	Shared Neighborhood Hits	4
SwissProt Accessions	O76009	Gene names	KRTHA3A, HHA3-I, HKA3A
Domain Architecture
Description	Keratin, type I cuticular Ha3-I (Hair keratin, type I Ha3-I).

ZN343_HUMAN
NC score	-0.000407 (rank : 65)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	56	Target Neighborhood Hits	768	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P1L6, Q5JXU8, Q5JXU9, Q8N8F2, Q96EX8, Q96NA5, Q9BQB0	Gene names	ZNF343
Domain Architecture	No domain graphic available
Description	Zinc finger protein 343.