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Network neighborhood for query Sequence : TOP2B_MOUSE

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TOP2B_MOUSE
SwissProt Accessions	Q64511, Q7TQG4	Gene names	Top2b
Domain Architecture
Description	DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TOP2A_HUMAN
θ value	0 (rank : 1)	NC score	0.972292 (rank : 4)
Query Neighborhood Hits	80	Target Neighborhood Hits	135	Shared Neighborhood Hits	21
SwissProt Accessions	P11388, Q71UN1, Q9HB24, Q9HB25, Q9HB26, Q9UP44, Q9UQP9	Gene names	TOP2A, TOP2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

TOP2A_MOUSE
θ value	0 (rank : 2)	NC score	0.973513 (rank : 3)
Query Neighborhood Hits	80	Target Neighborhood Hits	101	Shared Neighborhood Hits	17
SwissProt Accessions	Q01320	Gene names	Top2a, Top-2, Top2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

TOP2B_HUMAN
θ value	0 (rank : 3)	NC score	0.988656 (rank : 2)
Query Neighborhood Hits	80	Target Neighborhood Hits	101	Shared Neighborhood Hits	46
SwissProt Accessions	Q02880, Q13600, Q9UMG8, Q9UQP8	Gene names	TOP2B
Domain Architecture
Description	DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme).

TOP2B_MOUSE
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	80	Target Neighborhood Hits	80	Shared Neighborhood Hits	80
SwissProt Accessions	Q64511, Q7TQG4	Gene names	Top2b
Domain Architecture
Description	DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme).

IWS1_HUMAN
θ value	0.00175202 (rank : 5)	NC score	0.106322 (rank : 5)
Query Neighborhood Hits	80	Target Neighborhood Hits	1241	Shared Neighborhood Hits	48
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

RBBP6_HUMAN
θ value	0.00298849 (rank : 6)	NC score	0.071764 (rank : 8)
Query Neighborhood Hits	80	Target Neighborhood Hits	1135	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

RRBP1_HUMAN
θ value	0.00390308 (rank : 7)	NC score	0.051043 (rank : 23)
Query Neighborhood Hits	80	Target Neighborhood Hits	1306	Shared Neighborhood Hits	29
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

IWS1_MOUSE
θ value	0.00509761 (rank : 8)	NC score	0.092117 (rank : 6)
Query Neighborhood Hits	80	Target Neighborhood Hits	1258	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

ATRX_MOUSE
θ value	0.00665767 (rank : 9)	NC score	0.057138 (rank : 16)
Query Neighborhood Hits	80	Target Neighborhood Hits	682	Shared Neighborhood Hits	36
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

TERF2_HUMAN
θ value	0.00869519 (rank : 10)	NC score	0.087293 (rank : 7)
Query Neighborhood Hits	80	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q15554	Gene names	TERF2, TRF2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

NC6IP_MOUSE
θ value	0.0563607 (rank : 11)	NC score	0.059590 (rank : 12)
Query Neighborhood Hits	80	Target Neighborhood Hits	161	Shared Neighborhood Hits	14
SwissProt Accessions	Q923W1, Q6DI60, Q6PEA7, Q8R0W9	Gene names	Ncoa6ip, Pimt
Domain Architecture	No domain graphic available
Description	Putative RNA methyltransferase NCOA6IP (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIPMT) (PIMT).

ADDB_MOUSE
θ value	0.163984 (rank : 12)	NC score	0.059997 (rank : 11)
Query Neighborhood Hits	80	Target Neighborhood Hits	574	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QYB8, Q3U0E1, Q80VH9, Q8C1C4, Q9CXE3, Q9JLE5, Q9QYB7	Gene names	Add2
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta) (Add97).

HXD10_HUMAN
θ value	0.21417 (rank : 13)	NC score	0.021530 (rank : 49)
Query Neighborhood Hits	80	Target Neighborhood Hits	392	Shared Neighborhood Hits	8
SwissProt Accessions	P28358	Gene names	HOXD10, HOX4D
Domain Architecture
Description	Homeobox protein Hox-D10 (Hox-4D) (Hox-4E).

HXD10_MOUSE
θ value	0.279714 (rank : 14)	NC score	0.020676 (rank : 52)
Query Neighborhood Hits	80	Target Neighborhood Hits	392	Shared Neighborhood Hits	8
SwissProt Accessions	P28359, Q91WU9	Gene names	Hoxd10, Hox-4.5, Hoxd-10
Domain Architecture
Description	Homeobox protein Hox-D10 (Hox-4.5) (Hox-5.3).

RRBP1_MOUSE
θ value	0.279714 (rank : 15)	NC score	0.029082 (rank : 40)
Query Neighborhood Hits	80	Target Neighborhood Hits	1650	Shared Neighborhood Hits	30
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

TERF2_MOUSE
θ value	0.279714 (rank : 16)	NC score	0.059446 (rank : 13)
Query Neighborhood Hits	80	Target Neighborhood Hits	128	Shared Neighborhood Hits	8
SwissProt Accessions	O35144	Gene names	Terf2, Trf2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

RGS3_HUMAN
θ value	0.365318 (rank : 17)	NC score	0.023980 (rank : 45)
Query Neighborhood Hits	80	Target Neighborhood Hits	1375	Shared Neighborhood Hits	20
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

MPP8_HUMAN
θ value	0.47712 (rank : 18)	NC score	0.031335 (rank : 35)
Query Neighborhood Hits	80	Target Neighborhood Hits	948	Shared Neighborhood Hits	26
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

AP3B2_HUMAN
θ value	0.62314 (rank : 19)	NC score	0.037950 (rank : 27)
Query Neighborhood Hits	80	Target Neighborhood Hits	246	Shared Neighborhood Hits	21
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

DSPP_MOUSE
θ value	0.62314 (rank : 20)	NC score	0.066523 (rank : 9)
Query Neighborhood Hits	80	Target Neighborhood Hits	491	Shared Neighborhood Hits	20
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

MBB1A_HUMAN
θ value	0.62314 (rank : 21)	NC score	0.051564 (rank : 22)
Query Neighborhood Hits	80	Target Neighborhood Hits	665	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

PDZD2_HUMAN
θ value	0.62314 (rank : 22)	NC score	0.020175 (rank : 54)
Query Neighborhood Hits	80	Target Neighborhood Hits	772	Shared Neighborhood Hits	17
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

TAOK2_MOUSE
θ value	0.62314 (rank : 23)	NC score	0.011227 (rank : 69)
Query Neighborhood Hits	80	Target Neighborhood Hits	1373	Shared Neighborhood Hits	16
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

WAPL_MOUSE
θ value	0.62314 (rank : 24)	NC score	0.039401 (rank : 25)
Query Neighborhood Hits	80	Target Neighborhood Hits	158	Shared Neighborhood Hits	17
SwissProt Accessions	Q65Z40, Q6ZQE9	Gene names	Wapal, Kiaa0261, Wapl
Domain Architecture	No domain graphic available
Description	Wings apart-like protein homolog (Dioxin-inducible factor 2) (DIF-2).

CF206_HUMAN
θ value	0.813845 (rank : 25)	NC score	0.053835 (rank : 18)
Query Neighborhood Hits	80	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H1X1	Gene names	C6orf206, MRPS18AL1
Domain Architecture	No domain graphic available
Description	Protein C6orf206.

NKTR_HUMAN
θ value	0.813845 (rank : 26)	NC score	0.037698 (rank : 28)
Query Neighborhood Hits	80	Target Neighborhood Hits	658	Shared Neighborhood Hits	29
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

PRP40_HUMAN
θ value	0.813845 (rank : 27)	NC score	0.041009 (rank : 24)
Query Neighborhood Hits	80	Target Neighborhood Hits	442	Shared Neighborhood Hits	18
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

TTF1_MOUSE
θ value	1.06291 (rank : 28)	NC score	0.053568 (rank : 20)
Query Neighborhood Hits	80	Target Neighborhood Hits	277	Shared Neighborhood Hits	17
SwissProt Accessions	Q62187, Q9JKK5	Gene names	Ttf1
Domain Architecture	No domain graphic available
Description	Transcription termination factor 1 (TTF-1) (TTF-I) (mTFF-I) (RNA polymerase I termination factor).

PACN2_MOUSE
θ value	1.38821 (rank : 29)	NC score	0.017205 (rank : 60)
Query Neighborhood Hits	80	Target Neighborhood Hits	382	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

DSPP_HUMAN
θ value	1.81305 (rank : 30)	NC score	0.058787 (rank : 14)
Query Neighborhood Hits	80	Target Neighborhood Hits	645	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

KI67_HUMAN
θ value	1.81305 (rank : 31)	NC score	0.038105 (rank : 26)
Query Neighborhood Hits	80	Target Neighborhood Hits	581	Shared Neighborhood Hits	21
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

SIA7A_MOUSE
θ value	1.81305 (rank : 32)	NC score	0.016958 (rank : 61)
Query Neighborhood Hits	80	Target Neighborhood Hits	203	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZ39, Q9JJP5	Gene names	St6galnac1, Siat7a
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

TR240_HUMAN
θ value	1.81305 (rank : 33)	NC score	0.026328 (rank : 42)
Query Neighborhood Hits	80	Target Neighborhood Hits	99	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UHV7, O60334	Gene names	THRAP1, ARC250, KIAA0593, TRAP240
Domain Architecture
Description	Thyroid hormone receptor-associated protein complex 240 kDa component (Trap240) (Thyroid hormone receptor-associated protein 1) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP 250) (Activator-recruited cofactor 250 kDa component) (ARC250).

TUFT1_HUMAN
θ value	1.81305 (rank : 34)	NC score	0.019352 (rank : 55)
Query Neighborhood Hits	80	Target Neighborhood Hits	686	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

TFAM_HUMAN
θ value	2.36792 (rank : 35)	NC score	0.034363 (rank : 33)
Query Neighborhood Hits	80	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	Q00059	Gene names	TFAM, TCF6L2
Domain Architecture
Description	Transcription factor A, mitochondrial precursor (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6-like 2).

ZN638_MOUSE
θ value	2.36792 (rank : 36)	NC score	0.031138 (rank : 36)
Query Neighborhood Hits	80	Target Neighborhood Hits	318	Shared Neighborhood Hits	12
SwissProt Accessions	Q61464, Q6DFV9, Q8C941	Gene names	Znf638, Np220, Zfml
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein).

ANK3_HUMAN
θ value	3.0926 (rank : 37)	NC score	0.009163 (rank : 77)
Query Neighborhood Hits	80	Target Neighborhood Hits	853	Shared Neighborhood Hits	21
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

CCND1_MOUSE
θ value	3.0926 (rank : 38)	NC score	0.025743 (rank : 43)
Query Neighborhood Hits	80	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	P25322	Gene names	Ccnd1, Cyl-1
Domain Architecture
Description	G1/S-specific cyclin-D1.

CDX4_HUMAN
θ value	3.0926 (rank : 39)	NC score	0.009218 (rank : 76)
Query Neighborhood Hits	80	Target Neighborhood Hits	366	Shared Neighborhood Hits	5
SwissProt Accessions	O14627, Q5JS20	Gene names	CDX4
Domain Architecture
Description	Homeobox protein CDX-4 (Caudal-type homeobox protein 4).

K0020_HUMAN
θ value	3.0926 (rank : 40)	NC score	0.018405 (rank : 57)
Query Neighborhood Hits	80	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q15397, Q547G7, Q5SZY9, Q6IB47, Q96B27, Q96L78, Q96L79, Q96L80	Gene names	KIAA0020, XTP5
Domain Architecture	No domain graphic available
Description	Protein KIAA0020 (HBV X-transactivated gene 5 protein) (Minor histocompatibility antigen HA-8) (HLA-HA8).

NIPBL_HUMAN
θ value	3.0926 (rank : 41)	NC score	0.035371 (rank : 31)
Query Neighborhood Hits	80	Target Neighborhood Hits	1311	Shared Neighborhood Hits	36
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

PRP40_MOUSE
θ value	3.0926 (rank : 42)	NC score	0.036238 (rank : 29)
Query Neighborhood Hits	80	Target Neighborhood Hits	447	Shared Neighborhood Hits	20
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

CCND1_HUMAN
θ value	4.03905 (rank : 43)	NC score	0.020558 (rank : 53)
Query Neighborhood Hits	80	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	P24385, Q6LEF0	Gene names	CCND1, BCL1, PRAD1
Domain Architecture
Description	G1/S-specific cyclin-D1 (PRAD1 oncogene) (BCL-1 oncogene).

CRBB3_MOUSE
θ value	4.03905 (rank : 44)	NC score	0.016142 (rank : 62)
Query Neighborhood Hits	80	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JJU9	Gene names	Crybb3
Domain Architecture
Description	Beta crystallin B3 (Beta-B3-crystallin).

DNMBP_MOUSE
θ value	4.03905 (rank : 45)	NC score	0.009958 (rank : 74)
Query Neighborhood Hits	80	Target Neighborhood Hits	435	Shared Neighborhood Hits	9
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

JIP1_MOUSE
θ value	4.03905 (rank : 46)	NC score	0.013399 (rank : 67)
Query Neighborhood Hits	80	Target Neighborhood Hits	259	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

SDPR_MOUSE
θ value	4.03905 (rank : 47)	NC score	0.021466 (rank : 50)
Query Neighborhood Hits	80	Target Neighborhood Hits	485	Shared Neighborhood Hits	11
SwissProt Accessions	Q63918, Q3V1P6, Q78EC3, Q8CBT4	Gene names	Sdpr, Sdr
Domain Architecture	No domain graphic available
Description	Serum deprivation-response protein (Phosphatidylserine-binding protein).

TAOK2_HUMAN
θ value	4.03905 (rank : 48)	NC score	0.005063 (rank : 84)
Query Neighborhood Hits	80	Target Neighborhood Hits	1172	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAU_MOUSE
θ value	4.03905 (rank : 49)	NC score	0.015822 (rank : 64)
Query Neighborhood Hits	80	Target Neighborhood Hits	502	Shared Neighborhood Hits	15
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

C8AP2_MOUSE
θ value	5.27518 (rank : 50)	NC score	0.017293 (rank : 59)
Query Neighborhood Hits	80	Target Neighborhood Hits	405	Shared Neighborhood Hits	17
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

DC12_HUMAN
θ value	5.27518 (rank : 51)	NC score	0.015861 (rank : 63)
Query Neighborhood Hits	80	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q96FZ2, Q96G34, Q9NRP3	Gene names	C3orf37
Domain Architecture	No domain graphic available
Description	UPF0361 protein DC12.

K1210_HUMAN
θ value	5.27518 (rank : 52)	NC score	0.029366 (rank : 38)
Query Neighborhood Hits	80	Target Neighborhood Hits	219	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ULL0, Q5JPN4	Gene names	KIAA1210
Domain Architecture	No domain graphic available
Description	Protein KIAA1210.

MLL2_HUMAN
θ value	5.27518 (rank : 53)	NC score	0.012882 (rank : 68)
Query Neighborhood Hits	80	Target Neighborhood Hits	1788	Shared Neighborhood Hits	24
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

NP1L3_MOUSE
θ value	5.27518 (rank : 54)	NC score	0.023527 (rank : 48)
Query Neighborhood Hits	80	Target Neighborhood Hits	233	Shared Neighborhood Hits	16
SwissProt Accessions	Q794H2, O54802	Gene names	Nap1l3, Mb20
Domain Architecture	No domain graphic available
Description	Nucleosome assembly protein 1-like 3 (Brain-specific protein MB20).

PEX5_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.029130 (rank : 39)
Query Neighborhood Hits	80	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	P50542, Q15115, Q15266	Gene names	PEX5, PXR1
Domain Architecture
Description	Peroxisomal targeting signal 1 receptor (Peroxisome receptor 1) (Peroxisomal C-terminal targeting signal import receptor) (PTS1-BP) (Peroxin-5) (PTS1 receptor).

SCG3_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.013558 (rank : 66)
Query Neighborhood Hits	80	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	P47867	Gene names	Scg3
Domain Architecture	No domain graphic available
Description	Secretogranin-3 precursor (Secretogranin III) (SgIII).

AFF4_HUMAN
θ value	6.88961 (rank : 57)	NC score	0.034792 (rank : 32)
Query Neighborhood Hits	80	Target Neighborhood Hits	611	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

AHTF1_HUMAN
θ value	6.88961 (rank : 58)	NC score	0.031019 (rank : 37)
Query Neighborhood Hits	80	Target Neighborhood Hits	286	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WYP5, Q7Z4E3, Q8IZA4, Q96EH9, Q9Y4Q6	Gene names	AHCTF1, ELYS, TMBS62
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

CEBPZ_MOUSE
θ value	6.88961 (rank : 59)	NC score	0.014336 (rank : 65)
Query Neighborhood Hits	80	Target Neighborhood Hits	60	Shared Neighborhood Hits	8
SwissProt Accessions	P53569, Q3TXW5, Q3TYA8, Q3UWQ7	Gene names	Cebpz, Cbf2, Cebpa-rs1
Domain Architecture
Description	CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CCAAT-binding factor) (CBF).

DUS16_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.008506 (rank : 79)
Query Neighborhood Hits	80	Target Neighborhood Hits	112	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BY84, Q9C0G3	Gene names	DUSP16, KIAA1700, MKP7
Domain Architecture
Description	Dual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).

ELOA1_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.023926 (rank : 46)
Query Neighborhood Hits	80	Target Neighborhood Hits	388	Shared Neighborhood Hits	21
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

ENL_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.035383 (rank : 30)
Query Neighborhood Hits	80	Target Neighborhood Hits	305	Shared Neighborhood Hits	24
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

FOG2_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.003430 (rank : 85)
Query Neighborhood Hits	80	Target Neighborhood Hits	714	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CCH7, Q9Z0F2	Gene names	Zfpm2, Fog2
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM2 (Zinc finger protein multitype 2) (Friend of GATA protein 2) (Friend of GATA-2) (FOG-2) (mFOG-2).

LEO1_HUMAN
θ value	6.88961 (rank : 64)	NC score	0.032735 (rank : 34)
Query Neighborhood Hits	80	Target Neighborhood Hits	958	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

PAR3L_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.009601 (rank : 75)
Query Neighborhood Hits	80	Target Neighborhood Hits	297	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

TCAL3_MOUSE
θ value	6.88961 (rank : 66)	NC score	0.023563 (rank : 47)
Query Neighborhood Hits	80	Target Neighborhood Hits	132	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R0A5, Q9CYK5, Q9D1S4	Gene names	Tceal3
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3).

VPS72_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.026668 (rank : 41)
Query Neighborhood Hits	80	Target Neighborhood Hits	274	Shared Neighborhood Hits	9
SwissProt Accessions	Q15906, Q53GJ2, Q5U0R4	Gene names	VPS72, TCFL1, YL1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

ABP1_MOUSE
θ value	8.99809 (rank : 68)	NC score	0.010047 (rank : 73)
Query Neighborhood Hits	80	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q8JZQ5, Q8R229, Q8VC36	Gene names	Abp1
Domain Architecture
Description	Amiloride-sensitive amine oxidase [copper-containing] precursor (EC 1.4.3.6) (Diamine oxidase) (DAO) (Amiloride-binding protein) (ABP) (Histaminase).

ADDB_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.018629 (rank : 56)
Query Neighborhood Hits	80	Target Neighborhood Hits	142	Shared Neighborhood Hits	6
SwissProt Accessions	P35612, Q13482, Q16412, Q59G82, Q5U5P4, Q6P0P2, Q6PGQ4, Q7Z688, Q7Z689, Q7Z690, Q7Z691	Gene names	ADD2, ADDB
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta).

CDX4_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.007239 (rank : 81)
Query Neighborhood Hits	80	Target Neighborhood Hits	378	Shared Neighborhood Hits	6
SwissProt Accessions	Q07424	Gene names	Cdx4, Cdx-4
Domain Architecture
Description	Homeobox protein CDX-4 (Caudal-type homeobox protein 4).

CT172_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.017552 (rank : 58)
Query Neighborhood Hits	80	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H410, Q5JW56, Q9H8P4	Gene names	C20orf172
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf172.

EP15R_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.005705 (rank : 83)
Query Neighborhood Hits	80	Target Neighborhood Hits	1135	Shared Neighborhood Hits	17
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

FMN2_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.010888 (rank : 70)
Query Neighborhood Hits	80	Target Neighborhood Hits	484	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

IPYR_HUMAN
θ value	8.99809 (rank : 74)	NC score	0.008276 (rank : 80)
Query Neighborhood Hits	80	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q15181, Q5SQT7, Q6P7P4, Q9UQJ5, Q9Y5B1	Gene names	PPA1, IOPPP, PP
Domain Architecture
Description	Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho- hydrolase) (PPase).

MAP9_MOUSE
θ value	8.99809 (rank : 75)	NC score	0.021132 (rank : 51)
Query Neighborhood Hits	80	Target Neighborhood Hits	529	Shared Neighborhood Hits	21
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

NF1_HUMAN
θ value	8.99809 (rank : 76)	NC score	0.010542 (rank : 71)
Query Neighborhood Hits	80	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

NF1_MOUSE
θ value	8.99809 (rank : 77)	NC score	0.010510 (rank : 72)
Query Neighborhood Hits	80	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

PCLO_HUMAN
θ value	8.99809 (rank : 78)	NC score	0.024055 (rank : 44)
Query Neighborhood Hits	80	Target Neighborhood Hits	2046	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PKNX1_MOUSE
θ value	8.99809 (rank : 79)	NC score	0.008957 (rank : 78)
Query Neighborhood Hits	80	Target Neighborhood Hits	103	Shared Neighborhood Hits	5
SwissProt Accessions	O70477	Gene names	Pknox1
Domain Architecture
Description	Homeobox protein PKNOX1 (PBX/knotted homeobox 1).

SSDH_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.006822 (rank : 82)
Query Neighborhood Hits	80	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	P51649	Gene names	ALDH5A1, SSADH
Domain Architecture
Description	Succinate semialdehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.24) (NAD(+)-dependent succinic semialdehyde dehydrogenase).

AKA12_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.052875 (rank : 21)
Query Neighborhood Hits	80	Target Neighborhood Hits	825	Shared Neighborhood Hits	32
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

NOLC1_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.058408 (rank : 15)
Query Neighborhood Hits	80	Target Neighborhood Hits	452	Shared Neighborhood Hits	30
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

R51A1_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.062224 (rank : 10)
Query Neighborhood Hits	80	Target Neighborhood Hits	164	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C551, O55219, Q8BP36, Q99L94, Q9D0J0	Gene names	Rad51ap1
Domain Architecture	No domain graphic available
Description	RAD51-associated protein 1 (RAD51-interacting protein) (RAB22).

TGON2_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.053718 (rank : 19)
Query Neighborhood Hits	80	Target Neighborhood Hits	1037	Shared Neighborhood Hits	38
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TXND2_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.054679 (rank : 17)
Query Neighborhood Hits	80	Target Neighborhood Hits	828	Shared Neighborhood Hits	31
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

Hits sorted by NC score

TOP2B_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	80	Target Neighborhood Hits	80	Shared Neighborhood Hits	80
SwissProt Accessions	Q64511, Q7TQG4	Gene names	Top2b
Domain Architecture
Description	DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme).

TOP2B_HUMAN
NC score	0.988656 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	80	Target Neighborhood Hits	101	Shared Neighborhood Hits	46
SwissProt Accessions	Q02880, Q13600, Q9UMG8, Q9UQP8	Gene names	TOP2B
Domain Architecture
Description	DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme).

TOP2A_MOUSE
NC score	0.973513 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	80	Target Neighborhood Hits	101	Shared Neighborhood Hits	17
SwissProt Accessions	Q01320	Gene names	Top2a, Top-2, Top2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

TOP2A_HUMAN
NC score	0.972292 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	80	Target Neighborhood Hits	135	Shared Neighborhood Hits	21
SwissProt Accessions	P11388, Q71UN1, Q9HB24, Q9HB25, Q9HB26, Q9UP44, Q9UQP9	Gene names	TOP2A, TOP2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

IWS1_HUMAN
NC score	0.106322 (rank : 5)	θ value	0.00175202 (rank : 5)
Query Neighborhood Hits	80	Target Neighborhood Hits	1241	Shared Neighborhood Hits	48
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

IWS1_MOUSE
NC score	0.092117 (rank : 6)	θ value	0.00509761 (rank : 8)
Query Neighborhood Hits	80	Target Neighborhood Hits	1258	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

TERF2_HUMAN
NC score	0.087293 (rank : 7)	θ value	0.00869519 (rank : 10)
Query Neighborhood Hits	80	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q15554	Gene names	TERF2, TRF2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

RBBP6_HUMAN
NC score	0.071764 (rank : 8)	θ value	0.00298849 (rank : 6)
Query Neighborhood Hits	80	Target Neighborhood Hits	1135	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

DSPP_MOUSE
NC score	0.066523 (rank : 9)	θ value	0.62314 (rank : 20)
Query Neighborhood Hits	80	Target Neighborhood Hits	491	Shared Neighborhood Hits	20
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

R51A1_MOUSE
NC score	0.062224 (rank : 10)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	80	Target Neighborhood Hits	164	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C551, O55219, Q8BP36, Q99L94, Q9D0J0	Gene names	Rad51ap1
Domain Architecture	No domain graphic available
Description	RAD51-associated protein 1 (RAD51-interacting protein) (RAB22).

ADDB_MOUSE
NC score	0.059997 (rank : 11)	θ value	0.163984 (rank : 12)
Query Neighborhood Hits	80	Target Neighborhood Hits	574	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QYB8, Q3U0E1, Q80VH9, Q8C1C4, Q9CXE3, Q9JLE5, Q9QYB7	Gene names	Add2
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta) (Add97).

NC6IP_MOUSE
NC score	0.059590 (rank : 12)	θ value	0.0563607 (rank : 11)
Query Neighborhood Hits	80	Target Neighborhood Hits	161	Shared Neighborhood Hits	14
SwissProt Accessions	Q923W1, Q6DI60, Q6PEA7, Q8R0W9	Gene names	Ncoa6ip, Pimt
Domain Architecture	No domain graphic available
Description	Putative RNA methyltransferase NCOA6IP (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIPMT) (PIMT).

TERF2_MOUSE
NC score	0.059446 (rank : 13)	θ value	0.279714 (rank : 16)
Query Neighborhood Hits	80	Target Neighborhood Hits	128	Shared Neighborhood Hits	8
SwissProt Accessions	O35144	Gene names	Terf2, Trf2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

DSPP_HUMAN
NC score	0.058787 (rank : 14)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	80	Target Neighborhood Hits	645	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

NOLC1_HUMAN
NC score	0.058408 (rank : 15)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	80	Target Neighborhood Hits	452	Shared Neighborhood Hits	30
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

ATRX_MOUSE
NC score	0.057138 (rank : 16)	θ value	0.00665767 (rank : 9)
Query Neighborhood Hits	80	Target Neighborhood Hits	682	Shared Neighborhood Hits	36
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

TXND2_MOUSE
NC score	0.054679 (rank : 17)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	80	Target Neighborhood Hits	828	Shared Neighborhood Hits	31
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

CF206_HUMAN
NC score	0.053835 (rank : 18)	θ value	0.813845 (rank : 25)
Query Neighborhood Hits	80	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H1X1	Gene names	C6orf206, MRPS18AL1
Domain Architecture	No domain graphic available
Description	Protein C6orf206.

TGON2_HUMAN
NC score	0.053718 (rank : 19)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	80	Target Neighborhood Hits	1037	Shared Neighborhood Hits	38
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TTF1_MOUSE
NC score	0.053568 (rank : 20)	θ value	1.06291 (rank : 28)
Query Neighborhood Hits	80	Target Neighborhood Hits	277	Shared Neighborhood Hits	17
SwissProt Accessions	Q62187, Q9JKK5	Gene names	Ttf1
Domain Architecture	No domain graphic available
Description	Transcription termination factor 1 (TTF-1) (TTF-I) (mTFF-I) (RNA polymerase I termination factor).

AKA12_HUMAN
NC score	0.052875 (rank : 21)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	80	Target Neighborhood Hits	825	Shared Neighborhood Hits	32
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

MBB1A_HUMAN
NC score	0.051564 (rank : 22)	θ value	0.62314 (rank : 21)
Query Neighborhood Hits	80	Target Neighborhood Hits	665	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

RRBP1_HUMAN
NC score	0.051043 (rank : 23)	θ value	0.00390308 (rank : 7)
Query Neighborhood Hits	80	Target Neighborhood Hits	1306	Shared Neighborhood Hits	29
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

PRP40_HUMAN
NC score	0.041009 (rank : 24)	θ value	0.813845 (rank : 27)
Query Neighborhood Hits	80	Target Neighborhood Hits	442	Shared Neighborhood Hits	18
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

WAPL_MOUSE
NC score	0.039401 (rank : 25)	θ value	0.62314 (rank : 24)
Query Neighborhood Hits	80	Target Neighborhood Hits	158	Shared Neighborhood Hits	17
SwissProt Accessions	Q65Z40, Q6ZQE9	Gene names	Wapal, Kiaa0261, Wapl
Domain Architecture	No domain graphic available
Description	Wings apart-like protein homolog (Dioxin-inducible factor 2) (DIF-2).

KI67_HUMAN
NC score	0.038105 (rank : 26)	θ value	1.81305 (rank : 31)
Query Neighborhood Hits	80	Target Neighborhood Hits	581	Shared Neighborhood Hits	21
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

AP3B2_HUMAN
NC score	0.037950 (rank : 27)	θ value	0.62314 (rank : 19)
Query Neighborhood Hits	80	Target Neighborhood Hits	246	Shared Neighborhood Hits	21
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

NKTR_HUMAN
NC score	0.037698 (rank : 28)	θ value	0.813845 (rank : 26)
Query Neighborhood Hits	80	Target Neighborhood Hits	658	Shared Neighborhood Hits	29
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

PRP40_MOUSE
NC score	0.036238 (rank : 29)	θ value	3.0926 (rank : 42)
Query Neighborhood Hits	80	Target Neighborhood Hits	447	Shared Neighborhood Hits	20
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

ENL_HUMAN
NC score	0.035383 (rank : 30)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	80	Target Neighborhood Hits	305	Shared Neighborhood Hits	24
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

NIPBL_HUMAN
NC score	0.035371 (rank : 31)	θ value	3.0926 (rank : 41)
Query Neighborhood Hits	80	Target Neighborhood Hits	1311	Shared Neighborhood Hits	36
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

AFF4_HUMAN
NC score	0.034792 (rank : 32)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	80	Target Neighborhood Hits	611	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

TFAM_HUMAN
NC score	0.034363 (rank : 33)	θ value	2.36792 (rank : 35)
Query Neighborhood Hits	80	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	Q00059	Gene names	TFAM, TCF6L2
Domain Architecture
Description	Transcription factor A, mitochondrial precursor (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6-like 2).

LEO1_HUMAN
NC score	0.032735 (rank : 34)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	80	Target Neighborhood Hits	958	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

MPP8_HUMAN
NC score	0.031335 (rank : 35)	θ value	0.47712 (rank : 18)
Query Neighborhood Hits	80	Target Neighborhood Hits	948	Shared Neighborhood Hits	26
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

ZN638_MOUSE
NC score	0.031138 (rank : 36)	θ value	2.36792 (rank : 36)
Query Neighborhood Hits	80	Target Neighborhood Hits	318	Shared Neighborhood Hits	12
SwissProt Accessions	Q61464, Q6DFV9, Q8C941	Gene names	Znf638, Np220, Zfml
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein).

AHTF1_HUMAN
NC score	0.031019 (rank : 37)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	80	Target Neighborhood Hits	286	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WYP5, Q7Z4E3, Q8IZA4, Q96EH9, Q9Y4Q6	Gene names	AHCTF1, ELYS, TMBS62
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

K1210_HUMAN
NC score	0.029366 (rank : 38)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	80	Target Neighborhood Hits	219	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ULL0, Q5JPN4	Gene names	KIAA1210
Domain Architecture	No domain graphic available
Description	Protein KIAA1210.

PEX5_HUMAN
NC score	0.029130 (rank : 39)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	80	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	P50542, Q15115, Q15266	Gene names	PEX5, PXR1
Domain Architecture
Description	Peroxisomal targeting signal 1 receptor (Peroxisome receptor 1) (Peroxisomal C-terminal targeting signal import receptor) (PTS1-BP) (Peroxin-5) (PTS1 receptor).

RRBP1_MOUSE
NC score	0.029082 (rank : 40)	θ value	0.279714 (rank : 15)
Query Neighborhood Hits	80	Target Neighborhood Hits	1650	Shared Neighborhood Hits	30
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

VPS72_HUMAN
NC score	0.026668 (rank : 41)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	80	Target Neighborhood Hits	274	Shared Neighborhood Hits	9
SwissProt Accessions	Q15906, Q53GJ2, Q5U0R4	Gene names	VPS72, TCFL1, YL1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

TR240_HUMAN
NC score	0.026328 (rank : 42)	θ value	1.81305 (rank : 33)
Query Neighborhood Hits	80	Target Neighborhood Hits	99	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UHV7, O60334	Gene names	THRAP1, ARC250, KIAA0593, TRAP240
Domain Architecture
Description	Thyroid hormone receptor-associated protein complex 240 kDa component (Trap240) (Thyroid hormone receptor-associated protein 1) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP 250) (Activator-recruited cofactor 250 kDa component) (ARC250).

CCND1_MOUSE
NC score	0.025743 (rank : 43)	θ value	3.0926 (rank : 38)
Query Neighborhood Hits	80	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	P25322	Gene names	Ccnd1, Cyl-1
Domain Architecture
Description	G1/S-specific cyclin-D1.

PCLO_HUMAN
NC score	0.024055 (rank : 44)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	80	Target Neighborhood Hits	2046	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RGS3_HUMAN
NC score	0.023980 (rank : 45)	θ value	0.365318 (rank : 17)
Query Neighborhood Hits	80	Target Neighborhood Hits	1375	Shared Neighborhood Hits	20
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

ELOA1_HUMAN
NC score	0.023926 (rank : 46)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	80	Target Neighborhood Hits	388	Shared Neighborhood Hits	21
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

TCAL3_MOUSE
NC score	0.023563 (rank : 47)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	80	Target Neighborhood Hits	132	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R0A5, Q9CYK5, Q9D1S4	Gene names	Tceal3
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3).

NP1L3_MOUSE
NC score	0.023527 (rank : 48)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	80	Target Neighborhood Hits	233	Shared Neighborhood Hits	16
SwissProt Accessions	Q794H2, O54802	Gene names	Nap1l3, Mb20
Domain Architecture	No domain graphic available
Description	Nucleosome assembly protein 1-like 3 (Brain-specific protein MB20).

HXD10_HUMAN
NC score	0.021530 (rank : 49)	θ value	0.21417 (rank : 13)
Query Neighborhood Hits	80	Target Neighborhood Hits	392	Shared Neighborhood Hits	8
SwissProt Accessions	P28358	Gene names	HOXD10, HOX4D
Domain Architecture
Description	Homeobox protein Hox-D10 (Hox-4D) (Hox-4E).

SDPR_MOUSE
NC score	0.021466 (rank : 50)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	80	Target Neighborhood Hits	485	Shared Neighborhood Hits	11
SwissProt Accessions	Q63918, Q3V1P6, Q78EC3, Q8CBT4	Gene names	Sdpr, Sdr
Domain Architecture	No domain graphic available
Description	Serum deprivation-response protein (Phosphatidylserine-binding protein).

MAP9_MOUSE
NC score	0.021132 (rank : 51)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	80	Target Neighborhood Hits	529	Shared Neighborhood Hits	21
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

HXD10_MOUSE
NC score	0.020676 (rank : 52)	θ value	0.279714 (rank : 14)
Query Neighborhood Hits	80	Target Neighborhood Hits	392	Shared Neighborhood Hits	8
SwissProt Accessions	P28359, Q91WU9	Gene names	Hoxd10, Hox-4.5, Hoxd-10
Domain Architecture
Description	Homeobox protein Hox-D10 (Hox-4.5) (Hox-5.3).

CCND1_HUMAN
NC score	0.020558 (rank : 53)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	80	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	P24385, Q6LEF0	Gene names	CCND1, BCL1, PRAD1
Domain Architecture
Description	G1/S-specific cyclin-D1 (PRAD1 oncogene) (BCL-1 oncogene).

PDZD2_HUMAN
NC score	0.020175 (rank : 54)	θ value	0.62314 (rank : 22)
Query Neighborhood Hits	80	Target Neighborhood Hits	772	Shared Neighborhood Hits	17
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

TUFT1_HUMAN
NC score	0.019352 (rank : 55)	θ value	1.81305 (rank : 34)
Query Neighborhood Hits	80	Target Neighborhood Hits	686	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

ADDB_HUMAN
NC score	0.018629 (rank : 56)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	80	Target Neighborhood Hits	142	Shared Neighborhood Hits	6
SwissProt Accessions	P35612, Q13482, Q16412, Q59G82, Q5U5P4, Q6P0P2, Q6PGQ4, Q7Z688, Q7Z689, Q7Z690, Q7Z691	Gene names	ADD2, ADDB
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta).

K0020_HUMAN
NC score	0.018405 (rank : 57)	θ value	3.0926 (rank : 40)
Query Neighborhood Hits	80	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q15397, Q547G7, Q5SZY9, Q6IB47, Q96B27, Q96L78, Q96L79, Q96L80	Gene names	KIAA0020, XTP5
Domain Architecture	No domain graphic available
Description	Protein KIAA0020 (HBV X-transactivated gene 5 protein) (Minor histocompatibility antigen HA-8) (HLA-HA8).

CT172_HUMAN
NC score	0.017552 (rank : 58)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	80	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H410, Q5JW56, Q9H8P4	Gene names	C20orf172
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf172.

C8AP2_MOUSE
NC score	0.017293 (rank : 59)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	80	Target Neighborhood Hits	405	Shared Neighborhood Hits	17
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

PACN2_MOUSE
NC score	0.017205 (rank : 60)	θ value	1.38821 (rank : 29)
Query Neighborhood Hits	80	Target Neighborhood Hits	382	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SIA7A_MOUSE
NC score	0.016958 (rank : 61)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	80	Target Neighborhood Hits	203	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZ39, Q9JJP5	Gene names	St6galnac1, Siat7a
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

CRBB3_MOUSE
NC score	0.016142 (rank : 62)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	80	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JJU9	Gene names	Crybb3
Domain Architecture
Description	Beta crystallin B3 (Beta-B3-crystallin).

DC12_HUMAN
NC score	0.015861 (rank : 63)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	80	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q96FZ2, Q96G34, Q9NRP3	Gene names	C3orf37
Domain Architecture	No domain graphic available
Description	UPF0361 protein DC12.

TAU_MOUSE
NC score	0.015822 (rank : 64)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	80	Target Neighborhood Hits	502	Shared Neighborhood Hits	15
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

CEBPZ_MOUSE
NC score	0.014336 (rank : 65)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	80	Target Neighborhood Hits	60	Shared Neighborhood Hits	8
SwissProt Accessions	P53569, Q3TXW5, Q3TYA8, Q3UWQ7	Gene names	Cebpz, Cbf2, Cebpa-rs1
Domain Architecture
Description	CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CCAAT-binding factor) (CBF).

SCG3_MOUSE
NC score	0.013558 (rank : 66)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	80	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	P47867	Gene names	Scg3
Domain Architecture	No domain graphic available
Description	Secretogranin-3 precursor (Secretogranin III) (SgIII).

JIP1_MOUSE
NC score	0.013399 (rank : 67)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	80	Target Neighborhood Hits	259	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

MLL2_HUMAN
NC score	0.012882 (rank : 68)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	80	Target Neighborhood Hits	1788	Shared Neighborhood Hits	24
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

TAOK2_MOUSE
NC score	0.011227 (rank : 69)	θ value	0.62314 (rank : 23)
Query Neighborhood Hits	80	Target Neighborhood Hits	1373	Shared Neighborhood Hits	16
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

FMN2_HUMAN
NC score	0.010888 (rank : 70)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	80	Target Neighborhood Hits	484	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

NF1_HUMAN
NC score	0.010542 (rank : 71)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	80	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

NF1_MOUSE
NC score	0.010510 (rank : 72)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	80	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

ABP1_MOUSE
NC score	0.010047 (rank : 73)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	80	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q8JZQ5, Q8R229, Q8VC36	Gene names	Abp1
Domain Architecture
Description	Amiloride-sensitive amine oxidase [copper-containing] precursor (EC 1.4.3.6) (Diamine oxidase) (DAO) (Amiloride-binding protein) (ABP) (Histaminase).

DNMBP_MOUSE
NC score	0.009958 (rank : 74)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	80	Target Neighborhood Hits	435	Shared Neighborhood Hits	9
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PAR3L_HUMAN
NC score	0.009601 (rank : 75)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	80	Target Neighborhood Hits	297	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

CDX4_HUMAN
NC score	0.009218 (rank : 76)	θ value	3.0926 (rank : 39)
Query Neighborhood Hits	80	Target Neighborhood Hits	366	Shared Neighborhood Hits	5
SwissProt Accessions	O14627, Q5JS20	Gene names	CDX4
Domain Architecture
Description	Homeobox protein CDX-4 (Caudal-type homeobox protein 4).

ANK3_HUMAN
NC score	0.009163 (rank : 77)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	80	Target Neighborhood Hits	853	Shared Neighborhood Hits	21
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

PKNX1_MOUSE
NC score	0.008957 (rank : 78)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	80	Target Neighborhood Hits	103	Shared Neighborhood Hits	5
SwissProt Accessions	O70477	Gene names	Pknox1
Domain Architecture
Description	Homeobox protein PKNOX1 (PBX/knotted homeobox 1).

DUS16_HUMAN
NC score	0.008506 (rank : 79)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	80	Target Neighborhood Hits	112	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BY84, Q9C0G3	Gene names	DUSP16, KIAA1700, MKP7
Domain Architecture
Description	Dual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).

IPYR_HUMAN
NC score	0.008276 (rank : 80)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	80	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q15181, Q5SQT7, Q6P7P4, Q9UQJ5, Q9Y5B1	Gene names	PPA1, IOPPP, PP
Domain Architecture
Description	Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho- hydrolase) (PPase).

CDX4_MOUSE
NC score	0.007239 (rank : 81)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	80	Target Neighborhood Hits	378	Shared Neighborhood Hits	6
SwissProt Accessions	Q07424	Gene names	Cdx4, Cdx-4
Domain Architecture
Description	Homeobox protein CDX-4 (Caudal-type homeobox protein 4).

SSDH_HUMAN
NC score	0.006822 (rank : 82)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	80	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	P51649	Gene names	ALDH5A1, SSADH
Domain Architecture
Description	Succinate semialdehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.24) (NAD(+)-dependent succinic semialdehyde dehydrogenase).

EP15R_MOUSE
NC score	0.005705 (rank : 83)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	80	Target Neighborhood Hits	1135	Shared Neighborhood Hits	17
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

TAOK2_HUMAN
NC score	0.005063 (rank : 84)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	80	Target Neighborhood Hits	1172	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

FOG2_MOUSE
NC score	0.003430 (rank : 85)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	80	Target Neighborhood Hits	714	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CCH7, Q9Z0F2	Gene names	Zfpm2, Fog2
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM2 (Zinc finger protein multitype 2) (Friend of GATA protein 2) (Friend of GATA-2) (FOG-2) (mFOG-2).