Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : MMEL1_MOUSE

For an explanation of this page, click here

MMEL1_MOUSE
SwissProt Accessions	Q9JLI3, Q3U495, Q9ERK2, Q9ERK3, Q9QZV6, Q9QZV7	Gene names	Mmel1, Nep2, Nl1, Sep
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) (Neprilysin-like peptidase) (NEPLP) (Neprilysin-like 1) (NL-1) (Soluble secreted endopeptidase) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MMEL1_HUMAN
θ value	0 (rank : 1)	NC score	0.997070 (rank : 2)
Query Neighborhood Hits	48	Target Neighborhood Hits	35	Shared Neighborhood Hits	22
SwissProt Accessions	Q495T6, Q495T7, Q495T8, Q5SZS6, Q96PH9	Gene names	MMEL1, MELL1, MMEL2, NEP2
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

MMEL1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	48	Target Neighborhood Hits	48	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JLI3, Q3U495, Q9ERK2, Q9ERK3, Q9QZV6, Q9QZV7	Gene names	Mmel1, Nep2, Nl1, Sep
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) (Neprilysin-like peptidase) (NEPLP) (Neprilysin-like 1) (NL-1) (Soluble secreted endopeptidase) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

NEP_HUMAN
θ value	0 (rank : 3)	NC score	0.991078 (rank : 3)
Query Neighborhood Hits	48	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P08473	Gene names	MME, EPN
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen).

NEP_MOUSE
θ value	0 (rank : 4)	NC score	0.991038 (rank : 4)
Query Neighborhood Hits	48	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

ECE1_HUMAN
θ value	4.55495e-161 (rank : 5)	NC score	0.978906 (rank : 5)
Query Neighborhood Hits	48	Target Neighborhood Hits	27	Shared Neighborhood Hits	19
SwissProt Accessions	P42892, Q14217, Q58GE7, Q5THM5, Q5THM7, Q5THM8, Q9UJQ6, Q9UPF4, Q9UPM4, Q9Y501	Gene names	ECE1
Domain Architecture
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE1_MOUSE
θ value	5.94893e-161 (rank : 6)	NC score	0.978546 (rank : 6)
Query Neighborhood Hits	48	Target Neighborhood Hits	23	Shared Neighborhood Hits	15
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE2_HUMAN
θ value	1.32836e-152 (rank : 7)	NC score	0.975805 (rank : 9)
Query Neighborhood Hits	48	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	O60344, Q96NX3, Q96NX4	Gene names	ECE2, KIAA0604
Domain Architecture
Description	Endothelin-converting enzyme 2 (EC 3.4.24.71) (ECE-2).

PHEX_HUMAN
θ value	2.8663e-147 (rank : 8)	NC score	0.976017 (rank : 8)
Query Neighborhood Hits	48	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P78562, O00678, Q13646, Q93032, Q99827	Gene names	PHEX, PEX
Domain Architecture
Description	Phosphate-regulating neutral endopeptidase (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

PHEX_MOUSE
θ value	1.08919e-146 (rank : 9)	NC score	0.976197 (rank : 7)
Query Neighborhood Hits	48	Target Neighborhood Hits	14	Shared Neighborhood Hits	12
SwissProt Accessions	P70669, P97439	Gene names	Phex, Hyp, Pex
Domain Architecture
Description	Metalloendopeptidase homolog PEX (EC 3.4.24.-) (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

ECEL1_HUMAN
θ value	1.02182e-136 (rank : 10)	NC score	0.972502 (rank : 10)
Query Neighborhood Hits	48	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	O95672, Q45UD9, Q53RF9, Q6UW86, Q86TH4, Q9NY95	Gene names	ECEL1, XCE
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein).

ECEL1_MOUSE
θ value	1.63136e-134 (rank : 11)	NC score	0.972253 (rank : 11)
Query Neighborhood Hits	48	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JMI0	Gene names	Ecel1, Dine, Xce
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) (Damage-induced neuronal endopeptidase).

KELL_HUMAN
θ value	3.83135e-67 (rank : 12)	NC score	0.945681 (rank : 12)
Query Neighborhood Hits	48	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	P23276, Q96RS8, Q99885	Gene names	KEL
Domain Architecture
Description	Kell blood group glycoprotein (EC 3.4.24.-) (CD238 antigen).

GOGA4_MOUSE
θ value	0.0252991 (rank : 13)	NC score	0.021196 (rank : 27)
Query Neighborhood Hits	48	Target Neighborhood Hits	1939	Shared Neighborhood Hits	23
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

REST_HUMAN
θ value	0.0961366 (rank : 14)	NC score	0.018579 (rank : 29)
Query Neighborhood Hits	48	Target Neighborhood Hits	1605	Shared Neighborhood Hits	24
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

AZI1_HUMAN
θ value	0.125558 (rank : 15)	NC score	0.026726 (rank : 15)
Query Neighborhood Hits	48	Target Neighborhood Hits	1000	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

MYH4_HUMAN
θ value	0.125558 (rank : 16)	NC score	0.028378 (rank : 13)
Query Neighborhood Hits	48	Target Neighborhood Hits	1377	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

MYH4_MOUSE
θ value	0.125558 (rank : 17)	NC score	0.028368 (rank : 14)
Query Neighborhood Hits	48	Target Neighborhood Hits	1476	Shared Neighborhood Hits	28
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH1_MOUSE
θ value	0.47712 (rank : 18)	NC score	0.026652 (rank : 16)
Query Neighborhood Hits	48	Target Neighborhood Hits	1461	Shared Neighborhood Hits	28
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH8_HUMAN
θ value	0.62314 (rank : 19)	NC score	0.025128 (rank : 18)
Query Neighborhood Hits	48	Target Neighborhood Hits	1610	Shared Neighborhood Hits	27
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

RBCC1_MOUSE
θ value	0.813845 (rank : 20)	NC score	0.023860 (rank : 19)
Query Neighborhood Hits	48	Target Neighborhood Hits	1048	Shared Neighborhood Hits	25
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

SMC1A_MOUSE
θ value	1.38821 (rank : 21)	NC score	0.018833 (rank : 28)
Query Neighborhood Hits	48	Target Neighborhood Hits	1384	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

MYH13_HUMAN
θ value	1.81305 (rank : 22)	NC score	0.023811 (rank : 20)
Query Neighborhood Hits	48	Target Neighborhood Hits	1504	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

AT10A_MOUSE
θ value	2.36792 (rank : 23)	NC score	0.011955 (rank : 39)
Query Neighborhood Hits	48	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	O54827, Q8R3B8	Gene names	Atp10a, Atpc5, Pfatp
Domain Architecture
Description	Probable phospholipid-transporting ATPase VA (EC 3.6.3.1) (P-locus fat-associated ATPase).

AT10B_HUMAN
θ value	2.36792 (rank : 24)	NC score	0.011499 (rank : 43)
Query Neighborhood Hits	48	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	O94823, Q9H725	Gene names	ATP10B, ATPVB, KIAA0715
Domain Architecture
Description	Probable phospholipid-transporting ATPase VB (EC 3.6.3.1).

EMSY_MOUSE
θ value	2.36792 (rank : 25)	NC score	0.014969 (rank : 36)
Query Neighborhood Hits	48	Target Neighborhood Hits	294	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

SYNE1_HUMAN
θ value	2.36792 (rank : 26)	NC score	0.016543 (rank : 34)
Query Neighborhood Hits	48	Target Neighborhood Hits	1484	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

AT10A_HUMAN
θ value	3.0926 (rank : 27)	NC score	0.011633 (rank : 41)
Query Neighborhood Hits	48	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	O60312, Q969I4	Gene names	ATP10A, ATP10C, ATPVC, KIAA0566
Domain Architecture	No domain graphic available
Description	Probable phospholipid-transporting ATPase VA (EC 3.6.3.1) (ATPVA) (Aminophospholipid translocase VA).

LAMB1_MOUSE
θ value	3.0926 (rank : 28)	NC score	0.008969 (rank : 46)
Query Neighborhood Hits	48	Target Neighborhood Hits	919	Shared Neighborhood Hits	21
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

MYH1_HUMAN
θ value	3.0926 (rank : 29)	NC score	0.025790 (rank : 17)
Query Neighborhood Hits	48	Target Neighborhood Hits	1478	Shared Neighborhood Hits	28
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

NF1_HUMAN
θ value	3.0926 (rank : 30)	NC score	0.021961 (rank : 23)
Query Neighborhood Hits	48	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

NF1_MOUSE
θ value	3.0926 (rank : 31)	NC score	0.021899 (rank : 25)
Query Neighborhood Hits	48	Target Neighborhood Hits	62	Shared Neighborhood Hits	6
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

CHD3_HUMAN
θ value	4.03905 (rank : 32)	NC score	0.003129 (rank : 48)
Query Neighborhood Hits	48	Target Neighborhood Hits	397	Shared Neighborhood Hits	4
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

GOGA4_HUMAN
θ value	4.03905 (rank : 33)	NC score	0.017535 (rank : 32)
Query Neighborhood Hits	48	Target Neighborhood Hits	2034	Shared Neighborhood Hits	25
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

HOOK2_MOUSE
θ value	4.03905 (rank : 34)	NC score	0.014142 (rank : 38)
Query Neighborhood Hits	48	Target Neighborhood Hits	736	Shared Neighborhood Hits	22
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

FUT2_MOUSE
θ value	5.27518 (rank : 35)	NC score	0.011395 (rank : 44)
Query Neighborhood Hits	48	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JL27	Gene names	Fut2, Sec2
Domain Architecture
Description	Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (GDP-L- fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (Secretory blood group protein 2).

PSMD2_HUMAN
θ value	5.27518 (rank : 36)	NC score	0.018014 (rank : 30)
Query Neighborhood Hits	48	Target Neighborhood Hits	88	Shared Neighborhood Hits	14
SwissProt Accessions	Q13200, Q12932, Q15321, Q96I12	Gene names	PSMD2, TRAP2
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Tumor necrosis factor type 1 receptor- associated protein 2) (55.11 protein).

PSMD2_MOUSE
θ value	5.27518 (rank : 37)	NC score	0.017564 (rank : 31)
Query Neighborhood Hits	48	Target Neighborhood Hits	147	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VDM4	Gene names	Psmd2
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97).

SEC1_MOUSE
θ value	5.27518 (rank : 38)	NC score	0.011674 (rank : 40)
Query Neighborhood Hits	48	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P97353, Q91V73, Q920T3, Q920T4	Gene names	Sec1, Fut10
Domain Architecture
Description	Galactoside 2-alpha-L-fucosyltransferase 3 (EC 2.4.1.69) (GDP-L- fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 3) (Alpha(1,2)FT 3) (Fucosyltransferase 10) (Secretory blood group protein 1).

SMC1A_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.015447 (rank : 35)
Query Neighborhood Hits	48	Target Neighborhood Hits	1346	Shared Neighborhood Hits	23
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

CCD11_MOUSE
θ value	6.88961 (rank : 40)	NC score	0.014715 (rank : 37)
Query Neighborhood Hits	48	Target Neighborhood Hits	498	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

GIMA7_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.007228 (rank : 47)
Query Neighborhood Hits	48	Target Neighborhood Hits	93	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NHV1	Gene names	GIMAP7, IAN7
Domain Architecture	No domain graphic available
Description	GTPase, IMAP family member 7 (Immunity-associated nucleotide 7 protein).

MYH2_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.023214 (rank : 21)
Query Neighborhood Hits	48	Target Neighborhood Hits	1491	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH3_HUMAN
θ value	6.88961 (rank : 43)	NC score	0.021929 (rank : 24)
Query Neighborhood Hits	48	Target Neighborhood Hits	1660	Shared Neighborhood Hits	28
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYH8_MOUSE
θ value	6.88961 (rank : 44)	NC score	0.021981 (rank : 22)
Query Neighborhood Hits	48	Target Neighborhood Hits	1600	Shared Neighborhood Hits	26
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

EMSY_HUMAN
θ value	8.99809 (rank : 45)	NC score	0.011536 (rank : 42)
Query Neighborhood Hits	48	Target Neighborhood Hits	296	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

LAMB1_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.009282 (rank : 45)
Query Neighborhood Hits	48	Target Neighborhood Hits	1018	Shared Neighborhood Hits	23
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

MYH7_HUMAN
θ value	8.99809 (rank : 47)	NC score	0.021690 (rank : 26)
Query Neighborhood Hits	48	Target Neighborhood Hits	1559	Shared Neighborhood Hits	26
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MYO15_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.017257 (rank : 33)
Query Neighborhood Hits	48	Target Neighborhood Hits	671	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

Hits sorted by NC score

MMEL1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	48	Target Neighborhood Hits	48	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JLI3, Q3U495, Q9ERK2, Q9ERK3, Q9QZV6, Q9QZV7	Gene names	Mmel1, Nep2, Nl1, Sep
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) (Neprilysin-like peptidase) (NEPLP) (Neprilysin-like 1) (NL-1) (Soluble secreted endopeptidase) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

MMEL1_HUMAN
NC score	0.997070 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	48	Target Neighborhood Hits	35	Shared Neighborhood Hits	22
SwissProt Accessions	Q495T6, Q495T7, Q495T8, Q5SZS6, Q96PH9	Gene names	MMEL1, MELL1, MMEL2, NEP2
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

NEP_HUMAN
NC score	0.991078 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	48	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P08473	Gene names	MME, EPN
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen).

NEP_MOUSE
NC score	0.991038 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	48	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

ECE1_HUMAN
NC score	0.978906 (rank : 5)	θ value	4.55495e-161 (rank : 5)
Query Neighborhood Hits	48	Target Neighborhood Hits	27	Shared Neighborhood Hits	19
SwissProt Accessions	P42892, Q14217, Q58GE7, Q5THM5, Q5THM7, Q5THM8, Q9UJQ6, Q9UPF4, Q9UPM4, Q9Y501	Gene names	ECE1
Domain Architecture
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE1_MOUSE
NC score	0.978546 (rank : 6)	θ value	5.94893e-161 (rank : 6)
Query Neighborhood Hits	48	Target Neighborhood Hits	23	Shared Neighborhood Hits	15
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

PHEX_MOUSE
NC score	0.976197 (rank : 7)	θ value	1.08919e-146 (rank : 9)
Query Neighborhood Hits	48	Target Neighborhood Hits	14	Shared Neighborhood Hits	12
SwissProt Accessions	P70669, P97439	Gene names	Phex, Hyp, Pex
Domain Architecture
Description	Metalloendopeptidase homolog PEX (EC 3.4.24.-) (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

PHEX_HUMAN
NC score	0.976017 (rank : 8)	θ value	2.8663e-147 (rank : 8)
Query Neighborhood Hits	48	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P78562, O00678, Q13646, Q93032, Q99827	Gene names	PHEX, PEX
Domain Architecture
Description	Phosphate-regulating neutral endopeptidase (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

ECE2_HUMAN
NC score	0.975805 (rank : 9)	θ value	1.32836e-152 (rank : 7)
Query Neighborhood Hits	48	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	O60344, Q96NX3, Q96NX4	Gene names	ECE2, KIAA0604
Domain Architecture
Description	Endothelin-converting enzyme 2 (EC 3.4.24.71) (ECE-2).

ECEL1_HUMAN
NC score	0.972502 (rank : 10)	θ value	1.02182e-136 (rank : 10)
Query Neighborhood Hits	48	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	O95672, Q45UD9, Q53RF9, Q6UW86, Q86TH4, Q9NY95	Gene names	ECEL1, XCE
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein).

ECEL1_MOUSE
NC score	0.972253 (rank : 11)	θ value	1.63136e-134 (rank : 11)
Query Neighborhood Hits	48	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JMI0	Gene names	Ecel1, Dine, Xce
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) (Damage-induced neuronal endopeptidase).

KELL_HUMAN
NC score	0.945681 (rank : 12)	θ value	3.83135e-67 (rank : 12)
Query Neighborhood Hits	48	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	P23276, Q96RS8, Q99885	Gene names	KEL
Domain Architecture
Description	Kell blood group glycoprotein (EC 3.4.24.-) (CD238 antigen).

MYH4_HUMAN
NC score	0.028378 (rank : 13)	θ value	0.125558 (rank : 16)
Query Neighborhood Hits	48	Target Neighborhood Hits	1377	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

MYH4_MOUSE
NC score	0.028368 (rank : 14)	θ value	0.125558 (rank : 17)
Query Neighborhood Hits	48	Target Neighborhood Hits	1476	Shared Neighborhood Hits	28
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

AZI1_HUMAN
NC score	0.026726 (rank : 15)	θ value	0.125558 (rank : 15)
Query Neighborhood Hits	48	Target Neighborhood Hits	1000	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

MYH1_MOUSE
NC score	0.026652 (rank : 16)	θ value	0.47712 (rank : 18)
Query Neighborhood Hits	48	Target Neighborhood Hits	1461	Shared Neighborhood Hits	28
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH1_HUMAN
NC score	0.025790 (rank : 17)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	48	Target Neighborhood Hits	1478	Shared Neighborhood Hits	28
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH8_HUMAN
NC score	0.025128 (rank : 18)	θ value	0.62314 (rank : 19)
Query Neighborhood Hits	48	Target Neighborhood Hits	1610	Shared Neighborhood Hits	27
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

RBCC1_MOUSE
NC score	0.023860 (rank : 19)	θ value	0.813845 (rank : 20)
Query Neighborhood Hits	48	Target Neighborhood Hits	1048	Shared Neighborhood Hits	25
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

MYH13_HUMAN
NC score	0.023811 (rank : 20)	θ value	1.81305 (rank : 22)
Query Neighborhood Hits	48	Target Neighborhood Hits	1504	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYH2_HUMAN
NC score	0.023214 (rank : 21)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	48	Target Neighborhood Hits	1491	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH8_MOUSE
NC score	0.021981 (rank : 22)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	48	Target Neighborhood Hits	1600	Shared Neighborhood Hits	26
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

NF1_HUMAN
NC score	0.021961 (rank : 23)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	48	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

MYH3_HUMAN
NC score	0.021929 (rank : 24)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	48	Target Neighborhood Hits	1660	Shared Neighborhood Hits	28
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

NF1_MOUSE
NC score	0.021899 (rank : 25)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	48	Target Neighborhood Hits	62	Shared Neighborhood Hits	6
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

MYH7_HUMAN
NC score	0.021690 (rank : 26)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	48	Target Neighborhood Hits	1559	Shared Neighborhood Hits	26
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

GOGA4_MOUSE
NC score	0.021196 (rank : 27)	θ value	0.0252991 (rank : 13)
Query Neighborhood Hits	48	Target Neighborhood Hits	1939	Shared Neighborhood Hits	23
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

SMC1A_MOUSE
NC score	0.018833 (rank : 28)	θ value	1.38821 (rank : 21)
Query Neighborhood Hits	48	Target Neighborhood Hits	1384	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

REST_HUMAN
NC score	0.018579 (rank : 29)	θ value	0.0961366 (rank : 14)
Query Neighborhood Hits	48	Target Neighborhood Hits	1605	Shared Neighborhood Hits	24
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

PSMD2_HUMAN
NC score	0.018014 (rank : 30)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	48	Target Neighborhood Hits	88	Shared Neighborhood Hits	14
SwissProt Accessions	Q13200, Q12932, Q15321, Q96I12	Gene names	PSMD2, TRAP2
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Tumor necrosis factor type 1 receptor- associated protein 2) (55.11 protein).

PSMD2_MOUSE
NC score	0.017564 (rank : 31)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	48	Target Neighborhood Hits	147	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VDM4	Gene names	Psmd2
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97).

GOGA4_HUMAN
NC score	0.017535 (rank : 32)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	48	Target Neighborhood Hits	2034	Shared Neighborhood Hits	25
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

MYO15_HUMAN
NC score	0.017257 (rank : 33)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	48	Target Neighborhood Hits	671	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

SYNE1_HUMAN
NC score	0.016543 (rank : 34)	θ value	2.36792 (rank : 26)
Query Neighborhood Hits	48	Target Neighborhood Hits	1484	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

SMC1A_HUMAN
NC score	0.015447 (rank : 35)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	48	Target Neighborhood Hits	1346	Shared Neighborhood Hits	23
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

EMSY_MOUSE
NC score	0.014969 (rank : 36)	θ value	2.36792 (rank : 25)
Query Neighborhood Hits	48	Target Neighborhood Hits	294	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

CCD11_MOUSE
NC score	0.014715 (rank : 37)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	48	Target Neighborhood Hits	498	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

HOOK2_MOUSE
NC score	0.014142 (rank : 38)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	48	Target Neighborhood Hits	736	Shared Neighborhood Hits	22
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

AT10A_MOUSE
NC score	0.011955 (rank : 39)	θ value	2.36792 (rank : 23)
Query Neighborhood Hits	48	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	O54827, Q8R3B8	Gene names	Atp10a, Atpc5, Pfatp
Domain Architecture
Description	Probable phospholipid-transporting ATPase VA (EC 3.6.3.1) (P-locus fat-associated ATPase).

SEC1_MOUSE
NC score	0.011674 (rank : 40)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	48	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P97353, Q91V73, Q920T3, Q920T4	Gene names	Sec1, Fut10
Domain Architecture
Description	Galactoside 2-alpha-L-fucosyltransferase 3 (EC 2.4.1.69) (GDP-L- fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 3) (Alpha(1,2)FT 3) (Fucosyltransferase 10) (Secretory blood group protein 1).

AT10A_HUMAN
NC score	0.011633 (rank : 41)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	48	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	O60312, Q969I4	Gene names	ATP10A, ATP10C, ATPVC, KIAA0566
Domain Architecture	No domain graphic available
Description	Probable phospholipid-transporting ATPase VA (EC 3.6.3.1) (ATPVA) (Aminophospholipid translocase VA).

EMSY_HUMAN
NC score	0.011536 (rank : 42)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	48	Target Neighborhood Hits	296	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

AT10B_HUMAN
NC score	0.011499 (rank : 43)	θ value	2.36792 (rank : 24)
Query Neighborhood Hits	48	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	O94823, Q9H725	Gene names	ATP10B, ATPVB, KIAA0715
Domain Architecture
Description	Probable phospholipid-transporting ATPase VB (EC 3.6.3.1).

FUT2_MOUSE
NC score	0.011395 (rank : 44)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	48	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JL27	Gene names	Fut2, Sec2
Domain Architecture
Description	Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (GDP-L- fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (Secretory blood group protein 2).

LAMB1_HUMAN
NC score	0.009282 (rank : 45)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	48	Target Neighborhood Hits	1018	Shared Neighborhood Hits	23
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LAMB1_MOUSE
NC score	0.008969 (rank : 46)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	48	Target Neighborhood Hits	919	Shared Neighborhood Hits	21
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

GIMA7_HUMAN
NC score	0.007228 (rank : 47)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	48	Target Neighborhood Hits	93	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NHV1	Gene names	GIMAP7, IAN7
Domain Architecture	No domain graphic available
Description	GTPase, IMAP family member 7 (Immunity-associated nucleotide 7 protein).

CHD3_HUMAN
NC score	0.003129 (rank : 48)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	48	Target Neighborhood Hits	397	Shared Neighborhood Hits	4
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).