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Network neighborhood for query Sequence : PHEX_HUMAN

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PHEX_HUMAN
SwissProt Accessions	P78562, O00678, Q13646, Q93032, Q99827	Gene names	PHEX, PEX
Domain Architecture
Description	Phosphate-regulating neutral endopeptidase (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PHEX_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	P78562, O00678, Q13646, Q93032, Q99827	Gene names	PHEX, PEX
Domain Architecture
Description	Phosphate-regulating neutral endopeptidase (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

PHEX_MOUSE
θ value	0 (rank : 2)	NC score	0.999779 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	P70669, P97439	Gene names	Phex, Hyp, Pex
Domain Architecture
Description	Metalloendopeptidase homolog PEX (EC 3.4.24.-) (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

MMEL1_MOUSE
θ value	2.8663e-147 (rank : 3)	NC score	0.976017 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JLI3, Q3U495, Q9ERK2, Q9ERK3, Q9QZV6, Q9QZV7	Gene names	Mmel1, Nep2, Nl1, Sep
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) (Neprilysin-like peptidase) (NEPLP) (Neprilysin-like 1) (NL-1) (Soluble secreted endopeptidase) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

MMEL1_HUMAN
θ value	4.28312e-143 (rank : 4)	NC score	0.976123 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	Q495T6, Q495T7, Q495T8, Q5SZS6, Q96PH9	Gene names	MMEL1, MELL1, MMEL2, NEP2
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

ECE1_HUMAN
θ value	5.80223e-132 (rank : 5)	NC score	0.971854 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	P42892, Q14217, Q58GE7, Q5THM5, Q5THM7, Q5THM8, Q9UJQ6, Q9UPF4, Q9UPM4, Q9Y501	Gene names	ECE1
Domain Architecture
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE1_MOUSE
θ value	3.76091e-131 (rank : 6)	NC score	0.972078 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

NEP_HUMAN
θ value	2.52267e-127 (rank : 7)	NC score	0.973773 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P08473	Gene names	MME, EPN
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen).

NEP_MOUSE
θ value	4.75757e-126 (rank : 8)	NC score	0.973436 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

ECE2_HUMAN
θ value	1.29561e-123 (rank : 9)	NC score	0.970166 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	O60344, Q96NX3, Q96NX4	Gene names	ECE2, KIAA0604
Domain Architecture
Description	Endothelin-converting enzyme 2 (EC 3.4.24.71) (ECE-2).

ECEL1_MOUSE
θ value	1.94503e-103 (rank : 10)	NC score	0.963492 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JMI0	Gene names	Ecel1, Dine, Xce
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) (Damage-induced neuronal endopeptidase).

ECEL1_HUMAN
θ value	9.98939e-100 (rank : 11)	NC score	0.963305 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	O95672, Q45UD9, Q53RF9, Q6UW86, Q86TH4, Q9NY95	Gene names	ECEL1, XCE
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein).

KELL_HUMAN
θ value	8.28633e-54 (rank : 12)	NC score	0.938420 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	P23276, Q96RS8, Q99885	Gene names	KEL
Domain Architecture
Description	Kell blood group glycoprotein (EC 3.4.24.-) (CD238 antigen).

C8AP2_HUMAN
θ value	2.36792 (rank : 13)	NC score	0.010776 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	548	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

FKB11_MOUSE
θ value	3.0926 (rank : 14)	NC score	0.018653 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D1M7, Q9CRE4	Gene names	Fkbp11
Domain Architecture
Description	FK506-binding protein 11 precursor (EC 5.2.1.8) (Peptidyl-prolyl cis- trans isomerase) (PPIase) (Rotamase) (19 kDa FK506-binding protein) (FKBP-19).

AN30A_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.000410 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	1119	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

SYMM_MOUSE
θ value	6.88961 (rank : 16)	NC score	0.008659 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q499X9, Q3T9W7, Q8BWR9, Q8BXY1	Gene names	Mars2
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.10) (Methionine--tRNA ligase 2) (Mitochondrial methionine--tRNA ligase) (MtMetRS).

UTP20_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.006626 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	Q5XG71, Q80V22, Q8BXH9, Q8CHL6, Q99K11	Gene names	Utp20, Drim
Domain Architecture	No domain graphic available
Description	Small subunit processome component 20 homolog (Down-regulated in metastasis protein).

Hits sorted by NC score

PHEX_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	P78562, O00678, Q13646, Q93032, Q99827	Gene names	PHEX, PEX
Domain Architecture
Description	Phosphate-regulating neutral endopeptidase (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

PHEX_MOUSE
NC score	0.999779 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	P70669, P97439	Gene names	Phex, Hyp, Pex
Domain Architecture
Description	Metalloendopeptidase homolog PEX (EC 3.4.24.-) (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein).

MMEL1_HUMAN
NC score	0.976123 (rank : 3)	θ value	4.28312e-143 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	Q495T6, Q495T7, Q495T8, Q5SZS6, Q96PH9	Gene names	MMEL1, MELL1, MMEL2, NEP2
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

MMEL1_MOUSE
NC score	0.976017 (rank : 4)	θ value	2.8663e-147 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JLI3, Q3U495, Q9ERK2, Q9ERK3, Q9QZV6, Q9QZV7	Gene names	Mmel1, Nep2, Nl1, Sep
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) (Neprilysin-like peptidase) (NEPLP) (Neprilysin-like 1) (NL-1) (Soluble secreted endopeptidase) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

NEP_HUMAN
NC score	0.973773 (rank : 5)	θ value	2.52267e-127 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P08473	Gene names	MME, EPN
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen).

NEP_MOUSE
NC score	0.973436 (rank : 6)	θ value	4.75757e-126 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

ECE1_MOUSE
NC score	0.972078 (rank : 7)	θ value	3.76091e-131 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	Q4PZA2, Q4PZ99, Q4PZA1, Q6P9Q9	Gene names	Ece1
Domain Architecture	No domain graphic available
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE1_HUMAN
NC score	0.971854 (rank : 8)	θ value	5.80223e-132 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	P42892, Q14217, Q58GE7, Q5THM5, Q5THM7, Q5THM8, Q9UJQ6, Q9UPF4, Q9UPM4, Q9Y501	Gene names	ECE1
Domain Architecture
Description	Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1).

ECE2_HUMAN
NC score	0.970166 (rank : 9)	θ value	1.29561e-123 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	O60344, Q96NX3, Q96NX4	Gene names	ECE2, KIAA0604
Domain Architecture
Description	Endothelin-converting enzyme 2 (EC 3.4.24.71) (ECE-2).

ECEL1_MOUSE
NC score	0.963492 (rank : 10)	θ value	1.94503e-103 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JMI0	Gene names	Ecel1, Dine, Xce
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) (Damage-induced neuronal endopeptidase).

ECEL1_HUMAN
NC score	0.963305 (rank : 11)	θ value	9.98939e-100 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	O95672, Q45UD9, Q53RF9, Q6UW86, Q86TH4, Q9NY95	Gene names	ECEL1, XCE
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein).

KELL_HUMAN
NC score	0.938420 (rank : 12)	θ value	8.28633e-54 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	P23276, Q96RS8, Q99885	Gene names	KEL
Domain Architecture
Description	Kell blood group glycoprotein (EC 3.4.24.-) (CD238 antigen).

FKB11_MOUSE
NC score	0.018653 (rank : 13)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D1M7, Q9CRE4	Gene names	Fkbp11
Domain Architecture
Description	FK506-binding protein 11 precursor (EC 5.2.1.8) (Peptidyl-prolyl cis- trans isomerase) (PPIase) (Rotamase) (19 kDa FK506-binding protein) (FKBP-19).

C8AP2_HUMAN
NC score	0.010776 (rank : 14)	θ value	2.36792 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	548	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

SYMM_MOUSE
NC score	0.008659 (rank : 15)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q499X9, Q3T9W7, Q8BWR9, Q8BXY1	Gene names	Mars2
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.10) (Methionine--tRNA ligase 2) (Mitochondrial methionine--tRNA ligase) (MtMetRS).

UTP20_MOUSE
NC score	0.006626 (rank : 16)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	Q5XG71, Q80V22, Q8BXH9, Q8CHL6, Q99K11	Gene names	Utp20, Drim
Domain Architecture	No domain graphic available
Description	Small subunit processome component 20 homolog (Down-regulated in metastasis protein).

AN30A_HUMAN
NC score	0.000410 (rank : 17)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	1119	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).