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Network neighborhood for query Sequence : AMPE_HUMAN

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AMPE_HUMAN
SwissProt Accessions	Q07075	Gene names	ENPEP
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (Differentiation antigen gp160) (CD249 antigen).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AMPE_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	Q07075	Gene names	ENPEP
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (Differentiation antigen gp160) (CD249 antigen).

AMPE_MOUSE
θ value	0 (rank : 2)	NC score	0.998150 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	35	Shared Neighborhood Hits	28
SwissProt Accessions	P16406	Gene names	Enpep
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (BP-1/6C3 antigen).

AMPN_HUMAN
θ value	4.55495e-161 (rank : 3)	NC score	0.977099 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	37	Shared Neighborhood Hits	22
SwissProt Accessions	P15144, Q16728, Q8IUK3, Q8IVH3, Q9UCE0	Gene names	ANPEP, APN, CD13, PEPN
Domain Architecture
Description	Aminopeptidase N (EC 3.4.11.2) (hAPN) (Alanyl aminopeptidase) (Microsomal aminopeptidase) (Aminopeptidase M) (gp150) (Myeloid plasma membrane glycoprotein CD13) (CD13 antigen).

ARTS1_MOUSE
θ value	3.49569e-153 (rank : 4)	NC score	0.974986 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q9EQH2, Q9ET63	Gene names	Arts1, Appils
Domain Architecture
Description	Adipocyte-derived leucine aminopeptidase precursor (EC 3.4.11.-) (A- LAP) (ARTS-1) (Aminopeptidase PILS) (Puromycin-insensitive leucyl- specific aminopeptidase) (PILS-AP) (VEGF-induced aminopeptidase).

AMPN_MOUSE
θ value	1.91815e-151 (rank : 5)	NC score	0.975583 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	22
SwissProt Accessions	P97449, Q91YH8, Q99K63	Gene names	Anpep, Lap-1, Lap1
Domain Architecture
Description	Aminopeptidase N (EC 3.4.11.2) (mAPN) (Alanyl aminopeptidase) (Microsomal aminopeptidase) (Aminopeptidase M) (Membrane protein p161) (CD13 antigen).

ARTS1_HUMAN
θ value	6.38546e-147 (rank : 6)	NC score	0.974753 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZ08, O60278, Q6UWY6, Q8NEL4, Q8TAD0, Q9UHF8, Q9UKY2	Gene names	ARTS1, APPILS, KIAA0525
Domain Architecture
Description	Adipocyte-derived leucine aminopeptidase precursor (EC 3.4.11.-) (A- LAP) (ARTS-1) (Aminopeptidase PILS) (Puromycin-insensitive leucyl- specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator).

TRHDE_MOUSE
θ value	2.12569e-142 (rank : 7)	NC score	0.968984 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	58	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K093	Gene names	Trhde
Domain Architecture	No domain graphic available
Description	Thyrotropin-releasing hormone-degrading ectoenzyme (EC 3.4.19.6) (TRH- degrading ectoenzyme) (TRH-DE) (TRH-specific aminopeptidase) (Thyroliberinase) (Pyroglutamyl-peptidase II) (PAP-II).

TRHDE_HUMAN
θ value	6.18479e-142 (rank : 8)	NC score	0.970483 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UKU6, Q6UWJ4	Gene names	TRHDE
Domain Architecture
Description	Thyrotropin-releasing hormone-degrading ectoenzyme (EC 3.4.19.6) (TRH- degrading ectoenzyme) (TRH-DE) (TRH-specific aminopeptidase) (Thyroliberinase) (Pyroglutamyl-peptidase II) (PAP-II).

PSA_MOUSE
θ value	7.8238e-137 (rank : 9)	NC score	0.970038 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	32	Shared Neighborhood Hits	24
SwissProt Accessions	Q11011, Q91VJ8	Gene names	Npepps, Psa
Domain Architecture
Description	Puromycin-sensitive aminopeptidase (EC 3.4.11.-) (PSA).

PSA_HUMAN
θ value	2.27638e-136 (rank : 10)	NC score	0.969990 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	24
SwissProt Accessions	P55786, Q6P145, Q9NP16, Q9UEM2	Gene names	NPEPPS, PSA
Domain Architecture
Description	Puromycin-sensitive aminopeptidase (EC 3.4.11.-) (PSA).

LCAP_HUMAN
θ value	1.80368e-133 (rank : 11)	NC score	0.974423 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UIQ6, O00769, Q15145, Q9UIQ7	Gene names	LNPEP, OTASE
Domain Architecture
Description	Leucyl-cystinyl aminopeptidase (EC 3.4.11.3) (Cystinyl aminopeptidase) (Oxytocinase) (OTase) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Placental leucine aminopeptidase) (P-LAP).

LAEVR_HUMAN
θ value	2.14053e-118 (rank : 12)	NC score	0.963031 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	73	Shared Neighborhood Hits	20
SwissProt Accessions	Q6Q4G3, Q32MR1, Q4G0I9, Q4G0V2, Q86XA3, Q8NBZ2	Gene names	LVRN
Domain Architecture	No domain graphic available
Description	Laeverin (EC 3.4.-.-) (CHL2 antigen).

LAEVR_MOUSE
θ value	7.70199e-76 (rank : 13)	NC score	0.955472 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	25	Shared Neighborhood Hits	20
SwissProt Accessions	Q2KHK3, Q9D633	Gene names	Lvrn
Domain Architecture	No domain graphic available
Description	Laeverin (EC 3.4.-.-).

LKHA4_HUMAN
θ value	6.62687e-19 (rank : 14)	NC score	0.696002 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	24	Shared Neighborhood Hits	20
SwissProt Accessions	P09960	Gene names	LTA4H, LTA4
Domain Architecture
Description	Leukotriene A-4 hydrolase (EC 3.3.2.6) (LTA-4 hydrolase) (Leukotriene A(4) hydrolase).

LKHA4_MOUSE
θ value	3.63628e-17 (rank : 15)	NC score	0.688492 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	P24527, Q8VDR8	Gene names	Lta4h
Domain Architecture
Description	Leukotriene A-4 hydrolase (EC 3.3.2.6) (LTA-4 hydrolase) (Leukotriene A(4) hydrolase).

AMPB_MOUSE
θ value	3.40345e-15 (rank : 16)	NC score	0.651714 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VCT3	Gene names	Rnpep
Domain Architecture
Description	Aminopeptidase B (EC 3.4.11.6) (Ap-B) (Arginyl aminopeptidase) (Arginine aminopeptidase) (Cytosol aminopeptidase IV).

AMPB_HUMAN
θ value	2.43908e-13 (rank : 17)	NC score	0.636908 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	28	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H4A4, Q9BVM9, Q9H1D4, Q9NPT7	Gene names	RNPEP, APB
Domain Architecture
Description	Aminopeptidase B (EC 3.4.11.6) (Ap-B) (Arginyl aminopeptidase) (Arginine aminopeptidase).

RNPL1_HUMAN
θ value	3.08544e-08 (rank : 18)	NC score	0.605235 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HAU8, Q96AC9, Q9H033, Q9NVD0	Gene names	RNPEPL1
Domain Architecture
Description	Arginyl aminopeptidase-like 1 (EC 3.4.11.-) (RNPEP-like protein).

AMPO_HUMAN
θ value	1.29631e-06 (rank : 19)	NC score	0.444341 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	22
SwissProt Accessions	Q8N6M6, Q5T9B1, Q5T9B3, Q5T9B4, Q8WUL6, Q96M23, Q96SS1	Gene names	ONPEP, C9orf3
Domain Architecture	No domain graphic available
Description	Aminopeptidase O (EC 3.4.11.-) (AP-O).

TAF2_HUMAN
θ value	0.00228821 (rank : 20)	NC score	0.227822 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	36	Shared Neighborhood Hits	17
SwissProt Accessions	Q6P1X5, O43487, O43604, O60668, Q86WW7, Q8IWK4	Gene names	TAF2, CIF150, TAF2B
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 2 (Transcription initiation factor TFIID 150 kDa subunit) (TBP-associated factor 150 kDa) (TAFII-150) (TAFII150) (150 kDa cofactor of initiator function).

TAF2_MOUSE
θ value	0.00298849 (rank : 21)	NC score	0.218881 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C176, Q8BKQ7	Gene names	Taf2
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 2 (Transcription initiation factor TFIID 150 kDa subunit) (TBP-associated factor 150 kDa).

AMPO_MOUSE
θ value	0.00390308 (rank : 22)	NC score	0.426821 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	25	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BXQ6, Q6P0W6, Q6P394, Q8BHX5	Gene names	Onpep
Domain Architecture	No domain graphic available
Description	Aminopeptidase O (EC 3.4.11.-) (AP-O).

ARHG7_HUMAN
θ value	0.279714 (rank : 23)	NC score	0.020682 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	347	Shared Neighborhood Hits	7
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG6_HUMAN
θ value	0.62314 (rank : 24)	NC score	0.023933 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	376	Shared Neighborhood Hits	9
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	0.62314 (rank : 25)	NC score	0.021507 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	394	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

PACN2_HUMAN
θ value	1.38821 (rank : 26)	NC score	0.020698 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	339	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	1.38821 (rank : 27)	NC score	0.020422 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	382	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

CSKP_HUMAN
θ value	2.36792 (rank : 28)	NC score	-0.000421 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	1022	Shared Neighborhood Hits	8
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

ILEU_HUMAN
θ value	2.36792 (rank : 29)	NC score	0.003796 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	81	Shared Neighborhood Hits	3
SwissProt Accessions	P30740, Q53FB9, Q5W0E1	Gene names	SERPINB1, ELANH2, PI2
Domain Architecture
Description	Leukocyte elastase inhibitor (LEI) (Serpin B1) (Monocyte/neutrophil elastase inhibitor) (M/NEI) (EI).

OCTC_HUMAN
θ value	2.36792 (rank : 30)	NC score	0.010583 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKG9, Q8IUW9, Q9Y6I2	Gene names	CROT, COT
Domain Architecture
Description	Peroxisomal carnitine O-octanoyltransferase (EC 2.3.1.137) (COT).

RAD9A_MOUSE
θ value	4.03905 (rank : 31)	NC score	0.011082 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z0F6, Q8QZZ3	Gene names	Rad9a, Rad9
Domain Architecture	No domain graphic available
Description	Cell cycle checkpoint control protein RAD9A (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) (Rad9-like protein) (mRAD9).

RO60_MOUSE
θ value	4.03905 (rank : 32)	NC score	0.012524 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	O08848, Q9QYD8	Gene names	Trove2, Ssa2
Domain Architecture
Description	60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2).

NF1_HUMAN
θ value	5.27518 (rank : 33)	NC score	0.014488 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

NF1_MOUSE
θ value	5.27518 (rank : 34)	NC score	0.014443 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

ARFG1_MOUSE
θ value	6.88961 (rank : 35)	NC score	0.005585 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

DMD_MOUSE
θ value	6.88961 (rank : 36)	NC score	-0.000304 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	1111	Shared Neighborhood Hits	6
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

HEP2_MOUSE
θ value	6.88961 (rank : 37)	NC score	0.002746 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	P49182	Gene names	Serpind1, Hcf2, Hcii
Domain Architecture
Description	Heparin cofactor 2 precursor (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin 2).

KLOT_MOUSE
θ value	6.88961 (rank : 38)	NC score	0.005048 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	O35082, O70175, O70621	Gene names	Kl
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].

OBF1_MOUSE
θ value	6.88961 (rank : 39)	NC score	0.009780 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q64693	Gene names	Pou2af1, Obf-1
Domain Architecture	No domain graphic available
Description	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (BOB1) (OCA-B).

SCN3A_HUMAN
θ value	6.88961 (rank : 40)	NC score	0.002109 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

STA13_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.003759 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

ECEL1_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.009876 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	O95672, Q45UD9, Q53RF9, Q6UW86, Q86TH4, Q9NY95	Gene names	ECEL1, XCE
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein).

ECEL1_MOUSE
θ value	8.99809 (rank : 43)	NC score	0.009874 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JMI0	Gene names	Ecel1, Dine, Xce
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) (Damage-induced neuronal endopeptidase).

OCTC_MOUSE
θ value	8.99809 (rank : 44)	NC score	0.007915 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DC50, Q921I4	Gene names	Crot, Cot
Domain Architecture
Description	Peroxisomal carnitine O-octanoyltransferase (EC 2.3.1.137) (COT).

SYT12_HUMAN
θ value	8.99809 (rank : 45)	NC score	0.002162 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

TSNA1_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.005813 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	178	Shared Neighborhood Hits	2
SwissProt Accessions	Q96NA8	Gene names	TSNARE1
Domain Architecture	No domain graphic available
Description	t-SNARE domain-containing protein 1.

Hits sorted by NC score

AMPE_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	Q07075	Gene names	ENPEP
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (Differentiation antigen gp160) (CD249 antigen).

AMPE_MOUSE
NC score	0.998150 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	35	Shared Neighborhood Hits	28
SwissProt Accessions	P16406	Gene names	Enpep
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (BP-1/6C3 antigen).

AMPN_HUMAN
NC score	0.977099 (rank : 3)	θ value	4.55495e-161 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	37	Shared Neighborhood Hits	22
SwissProt Accessions	P15144, Q16728, Q8IUK3, Q8IVH3, Q9UCE0	Gene names	ANPEP, APN, CD13, PEPN
Domain Architecture
Description	Aminopeptidase N (EC 3.4.11.2) (hAPN) (Alanyl aminopeptidase) (Microsomal aminopeptidase) (Aminopeptidase M) (gp150) (Myeloid plasma membrane glycoprotein CD13) (CD13 antigen).

AMPN_MOUSE
NC score	0.975583 (rank : 4)	θ value	1.91815e-151 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	22
SwissProt Accessions	P97449, Q91YH8, Q99K63	Gene names	Anpep, Lap-1, Lap1
Domain Architecture
Description	Aminopeptidase N (EC 3.4.11.2) (mAPN) (Alanyl aminopeptidase) (Microsomal aminopeptidase) (Aminopeptidase M) (Membrane protein p161) (CD13 antigen).

ARTS1_MOUSE
NC score	0.974986 (rank : 5)	θ value	3.49569e-153 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q9EQH2, Q9ET63	Gene names	Arts1, Appils
Domain Architecture
Description	Adipocyte-derived leucine aminopeptidase precursor (EC 3.4.11.-) (A- LAP) (ARTS-1) (Aminopeptidase PILS) (Puromycin-insensitive leucyl- specific aminopeptidase) (PILS-AP) (VEGF-induced aminopeptidase).

ARTS1_HUMAN
NC score	0.974753 (rank : 6)	θ value	6.38546e-147 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZ08, O60278, Q6UWY6, Q8NEL4, Q8TAD0, Q9UHF8, Q9UKY2	Gene names	ARTS1, APPILS, KIAA0525
Domain Architecture
Description	Adipocyte-derived leucine aminopeptidase precursor (EC 3.4.11.-) (A- LAP) (ARTS-1) (Aminopeptidase PILS) (Puromycin-insensitive leucyl- specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator).

LCAP_HUMAN
NC score	0.974423 (rank : 7)	θ value	1.80368e-133 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UIQ6, O00769, Q15145, Q9UIQ7	Gene names	LNPEP, OTASE
Domain Architecture
Description	Leucyl-cystinyl aminopeptidase (EC 3.4.11.3) (Cystinyl aminopeptidase) (Oxytocinase) (OTase) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Placental leucine aminopeptidase) (P-LAP).

TRHDE_HUMAN
NC score	0.970483 (rank : 8)	θ value	6.18479e-142 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UKU6, Q6UWJ4	Gene names	TRHDE
Domain Architecture
Description	Thyrotropin-releasing hormone-degrading ectoenzyme (EC 3.4.19.6) (TRH- degrading ectoenzyme) (TRH-DE) (TRH-specific aminopeptidase) (Thyroliberinase) (Pyroglutamyl-peptidase II) (PAP-II).

PSA_MOUSE
NC score	0.970038 (rank : 9)	θ value	7.8238e-137 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	32	Shared Neighborhood Hits	24
SwissProt Accessions	Q11011, Q91VJ8	Gene names	Npepps, Psa
Domain Architecture
Description	Puromycin-sensitive aminopeptidase (EC 3.4.11.-) (PSA).

PSA_HUMAN
NC score	0.969990 (rank : 10)	θ value	2.27638e-136 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	24
SwissProt Accessions	P55786, Q6P145, Q9NP16, Q9UEM2	Gene names	NPEPPS, PSA
Domain Architecture
Description	Puromycin-sensitive aminopeptidase (EC 3.4.11.-) (PSA).

TRHDE_MOUSE
NC score	0.968984 (rank : 11)	θ value	2.12569e-142 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	58	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K093	Gene names	Trhde
Domain Architecture	No domain graphic available
Description	Thyrotropin-releasing hormone-degrading ectoenzyme (EC 3.4.19.6) (TRH- degrading ectoenzyme) (TRH-DE) (TRH-specific aminopeptidase) (Thyroliberinase) (Pyroglutamyl-peptidase II) (PAP-II).

LAEVR_HUMAN
NC score	0.963031 (rank : 12)	θ value	2.14053e-118 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	73	Shared Neighborhood Hits	20
SwissProt Accessions	Q6Q4G3, Q32MR1, Q4G0I9, Q4G0V2, Q86XA3, Q8NBZ2	Gene names	LVRN
Domain Architecture	No domain graphic available
Description	Laeverin (EC 3.4.-.-) (CHL2 antigen).

LAEVR_MOUSE
NC score	0.955472 (rank : 13)	θ value	7.70199e-76 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	25	Shared Neighborhood Hits	20
SwissProt Accessions	Q2KHK3, Q9D633	Gene names	Lvrn
Domain Architecture	No domain graphic available
Description	Laeverin (EC 3.4.-.-).

LKHA4_HUMAN
NC score	0.696002 (rank : 14)	θ value	6.62687e-19 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	24	Shared Neighborhood Hits	20
SwissProt Accessions	P09960	Gene names	LTA4H, LTA4
Domain Architecture
Description	Leukotriene A-4 hydrolase (EC 3.3.2.6) (LTA-4 hydrolase) (Leukotriene A(4) hydrolase).

LKHA4_MOUSE
NC score	0.688492 (rank : 15)	θ value	3.63628e-17 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	P24527, Q8VDR8	Gene names	Lta4h
Domain Architecture
Description	Leukotriene A-4 hydrolase (EC 3.3.2.6) (LTA-4 hydrolase) (Leukotriene A(4) hydrolase).

AMPB_MOUSE
NC score	0.651714 (rank : 16)	θ value	3.40345e-15 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VCT3	Gene names	Rnpep
Domain Architecture
Description	Aminopeptidase B (EC 3.4.11.6) (Ap-B) (Arginyl aminopeptidase) (Arginine aminopeptidase) (Cytosol aminopeptidase IV).

AMPB_HUMAN
NC score	0.636908 (rank : 17)	θ value	2.43908e-13 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	28	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H4A4, Q9BVM9, Q9H1D4, Q9NPT7	Gene names	RNPEP, APB
Domain Architecture
Description	Aminopeptidase B (EC 3.4.11.6) (Ap-B) (Arginyl aminopeptidase) (Arginine aminopeptidase).

RNPL1_HUMAN
NC score	0.605235 (rank : 18)	θ value	3.08544e-08 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HAU8, Q96AC9, Q9H033, Q9NVD0	Gene names	RNPEPL1
Domain Architecture
Description	Arginyl aminopeptidase-like 1 (EC 3.4.11.-) (RNPEP-like protein).

AMPO_HUMAN
NC score	0.444341 (rank : 19)	θ value	1.29631e-06 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	22
SwissProt Accessions	Q8N6M6, Q5T9B1, Q5T9B3, Q5T9B4, Q8WUL6, Q96M23, Q96SS1	Gene names	ONPEP, C9orf3
Domain Architecture	No domain graphic available
Description	Aminopeptidase O (EC 3.4.11.-) (AP-O).

AMPO_MOUSE
NC score	0.426821 (rank : 20)	θ value	0.00390308 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	25	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BXQ6, Q6P0W6, Q6P394, Q8BHX5	Gene names	Onpep
Domain Architecture	No domain graphic available
Description	Aminopeptidase O (EC 3.4.11.-) (AP-O).

TAF2_HUMAN
NC score	0.227822 (rank : 21)	θ value	0.00228821 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	36	Shared Neighborhood Hits	17
SwissProt Accessions	Q6P1X5, O43487, O43604, O60668, Q86WW7, Q8IWK4	Gene names	TAF2, CIF150, TAF2B
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 2 (Transcription initiation factor TFIID 150 kDa subunit) (TBP-associated factor 150 kDa) (TAFII-150) (TAFII150) (150 kDa cofactor of initiator function).

TAF2_MOUSE
NC score	0.218881 (rank : 22)	θ value	0.00298849 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C176, Q8BKQ7	Gene names	Taf2
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 2 (Transcription initiation factor TFIID 150 kDa subunit) (TBP-associated factor 150 kDa).

ARHG6_HUMAN
NC score	0.023933 (rank : 23)	θ value	0.62314 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	376	Shared Neighborhood Hits	9
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
NC score	0.021507 (rank : 24)	θ value	0.62314 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	394	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

PACN2_HUMAN
NC score	0.020698 (rank : 25)	θ value	1.38821 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	339	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ARHG7_HUMAN
NC score	0.020682 (rank : 26)	θ value	0.279714 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	347	Shared Neighborhood Hits	7
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

PACN2_MOUSE
NC score	0.020422 (rank : 27)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	382	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

NF1_HUMAN
NC score	0.014488 (rank : 28)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

NF1_MOUSE
NC score	0.014443 (rank : 29)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

RO60_MOUSE
NC score	0.012524 (rank : 30)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	O08848, Q9QYD8	Gene names	Trove2, Ssa2
Domain Architecture
Description	60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2).

RAD9A_MOUSE
NC score	0.011082 (rank : 31)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z0F6, Q8QZZ3	Gene names	Rad9a, Rad9
Domain Architecture	No domain graphic available
Description	Cell cycle checkpoint control protein RAD9A (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) (Rad9-like protein) (mRAD9).

OCTC_HUMAN
NC score	0.010583 (rank : 32)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKG9, Q8IUW9, Q9Y6I2	Gene names	CROT, COT
Domain Architecture
Description	Peroxisomal carnitine O-octanoyltransferase (EC 2.3.1.137) (COT).

ECEL1_HUMAN
NC score	0.009876 (rank : 33)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	O95672, Q45UD9, Q53RF9, Q6UW86, Q86TH4, Q9NY95	Gene names	ECEL1, XCE
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein).

ECEL1_MOUSE
NC score	0.009874 (rank : 34)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JMI0	Gene names	Ecel1, Dine, Xce
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) (Damage-induced neuronal endopeptidase).

OBF1_MOUSE
NC score	0.009780 (rank : 35)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q64693	Gene names	Pou2af1, Obf-1
Domain Architecture	No domain graphic available
Description	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (BOB1) (OCA-B).

OCTC_MOUSE
NC score	0.007915 (rank : 36)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DC50, Q921I4	Gene names	Crot, Cot
Domain Architecture
Description	Peroxisomal carnitine O-octanoyltransferase (EC 2.3.1.137) (COT).

TSNA1_HUMAN
NC score	0.005813 (rank : 37)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	178	Shared Neighborhood Hits	2
SwissProt Accessions	Q96NA8	Gene names	TSNARE1
Domain Architecture	No domain graphic available
Description	t-SNARE domain-containing protein 1.

ARFG1_MOUSE
NC score	0.005585 (rank : 38)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

KLOT_MOUSE
NC score	0.005048 (rank : 39)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	O35082, O70175, O70621	Gene names	Kl
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].

ILEU_HUMAN
NC score	0.003796 (rank : 40)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	81	Shared Neighborhood Hits	3
SwissProt Accessions	P30740, Q53FB9, Q5W0E1	Gene names	SERPINB1, ELANH2, PI2
Domain Architecture
Description	Leukocyte elastase inhibitor (LEI) (Serpin B1) (Monocyte/neutrophil elastase inhibitor) (M/NEI) (EI).

STA13_HUMAN
NC score	0.003759 (rank : 41)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

HEP2_MOUSE
NC score	0.002746 (rank : 42)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	P49182	Gene names	Serpind1, Hcf2, Hcii
Domain Architecture
Description	Heparin cofactor 2 precursor (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin 2).

SYT12_HUMAN
NC score	0.002162 (rank : 43)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SCN3A_HUMAN
NC score	0.002109 (rank : 44)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

DMD_MOUSE
NC score	-0.000304 (rank : 45)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	1111	Shared Neighborhood Hits	6
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

CSKP_HUMAN
NC score	-0.000421 (rank : 46)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	1022	Shared Neighborhood Hits	8
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).