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Network neighborhood for query Sequence : TRHDE_HUMAN

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TRHDE_HUMAN
SwissProt Accessions	Q9UKU6, Q6UWJ4	Gene names	TRHDE
Domain Architecture
Description	Thyrotropin-releasing hormone-degrading ectoenzyme (EC 3.4.19.6) (TRH- degrading ectoenzyme) (TRH-DE) (TRH-specific aminopeptidase) (Thyroliberinase) (Pyroglutamyl-peptidase II) (PAP-II).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TRHDE_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UKU6, Q6UWJ4	Gene names	TRHDE
Domain Architecture
Description	Thyrotropin-releasing hormone-degrading ectoenzyme (EC 3.4.19.6) (TRH- degrading ectoenzyme) (TRH-DE) (TRH-specific aminopeptidase) (Thyroliberinase) (Pyroglutamyl-peptidase II) (PAP-II).

TRHDE_MOUSE
θ value	0 (rank : 2)	NC score	0.998457 (rank : 2)
Query Neighborhood Hits	49	Target Neighborhood Hits	58	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K093	Gene names	Trhde
Domain Architecture	No domain graphic available
Description	Thyrotropin-releasing hormone-degrading ectoenzyme (EC 3.4.19.6) (TRH- degrading ectoenzyme) (TRH-DE) (TRH-specific aminopeptidase) (Thyroliberinase) (Pyroglutamyl-peptidase II) (PAP-II).

AMPN_HUMAN
θ value	3.05528e-157 (rank : 3)	NC score	0.975465 (rank : 3)
Query Neighborhood Hits	49	Target Neighborhood Hits	37	Shared Neighborhood Hits	22
SwissProt Accessions	P15144, Q16728, Q8IUK3, Q8IVH3, Q9UCE0	Gene names	ANPEP, APN, CD13, PEPN
Domain Architecture
Description	Aminopeptidase N (EC 3.4.11.2) (hAPN) (Alanyl aminopeptidase) (Microsomal aminopeptidase) (Aminopeptidase M) (gp150) (Myeloid plasma membrane glycoprotein CD13) (CD13 antigen).

AMPN_MOUSE
θ value	1.46868e-151 (rank : 4)	NC score	0.974876 (rank : 4)
Query Neighborhood Hits	49	Target Neighborhood Hits	34	Shared Neighborhood Hits	22
SwissProt Accessions	P97449, Q91YH8, Q99K63	Gene names	Anpep, Lap-1, Lap1
Domain Architecture
Description	Aminopeptidase N (EC 3.4.11.2) (mAPN) (Alanyl aminopeptidase) (Microsomal aminopeptidase) (Aminopeptidase M) (Membrane protein p161) (CD13 antigen).

AMPE_HUMAN
θ value	6.18479e-142 (rank : 5)	NC score	0.970483 (rank : 5)
Query Neighborhood Hits	49	Target Neighborhood Hits	46	Shared Neighborhood Hits	22
SwissProt Accessions	Q07075	Gene names	ENPEP
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (Differentiation antigen gp160) (CD249 antigen).

ARTS1_MOUSE
θ value	1.28961e-139 (rank : 6)	NC score	0.968964 (rank : 8)
Query Neighborhood Hits	49	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q9EQH2, Q9ET63	Gene names	Arts1, Appils
Domain Architecture
Description	Adipocyte-derived leucine aminopeptidase precursor (EC 3.4.11.-) (A- LAP) (ARTS-1) (Aminopeptidase PILS) (Puromycin-insensitive leucyl- specific aminopeptidase) (PILS-AP) (VEGF-induced aminopeptidase).

AMPE_MOUSE
θ value	2.87295e-139 (rank : 7)	NC score	0.969839 (rank : 6)
Query Neighborhood Hits	49	Target Neighborhood Hits	35	Shared Neighborhood Hits	22
SwissProt Accessions	P16406	Gene names	Enpep
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (BP-1/6C3 antigen).

ARTS1_HUMAN
θ value	7.32286e-135 (rank : 8)	NC score	0.968176 (rank : 9)
Query Neighborhood Hits	49	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZ08, O60278, Q6UWY6, Q8NEL4, Q8TAD0, Q9UHF8, Q9UKY2	Gene names	ARTS1, APPILS, KIAA0525
Domain Architecture
Description	Adipocyte-derived leucine aminopeptidase precursor (EC 3.4.11.-) (A- LAP) (ARTS-1) (Aminopeptidase PILS) (Puromycin-insensitive leucyl- specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator).

LAEVR_HUMAN
θ value	3.5201e-129 (rank : 9)	NC score	0.965564 (rank : 10)
Query Neighborhood Hits	49	Target Neighborhood Hits	73	Shared Neighborhood Hits	20
SwissProt Accessions	Q6Q4G3, Q32MR1, Q4G0I9, Q4G0V2, Q86XA3, Q8NBZ2	Gene names	LVRN
Domain Architecture	No domain graphic available
Description	Laeverin (EC 3.4.-.-) (CHL2 antigen).

LCAP_HUMAN
θ value	2.61056e-124 (rank : 10)	NC score	0.969045 (rank : 7)
Query Neighborhood Hits	49	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UIQ6, O00769, Q15145, Q9UIQ7	Gene names	LNPEP, OTASE
Domain Architecture
Description	Leucyl-cystinyl aminopeptidase (EC 3.4.11.3) (Cystinyl aminopeptidase) (Oxytocinase) (OTase) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Placental leucine aminopeptidase) (P-LAP).

PSA_HUMAN
θ value	1.87955e-106 (rank : 11)	NC score	0.956285 (rank : 12)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	22
SwissProt Accessions	P55786, Q6P145, Q9NP16, Q9UEM2	Gene names	NPEPPS, PSA
Domain Architecture
Description	Puromycin-sensitive aminopeptidase (EC 3.4.11.-) (PSA).

PSA_MOUSE
θ value	2.71407e-105 (rank : 12)	NC score	0.956134 (rank : 13)
Query Neighborhood Hits	49	Target Neighborhood Hits	32	Shared Neighborhood Hits	22
SwissProt Accessions	Q11011, Q91VJ8	Gene names	Npepps, Psa
Domain Architecture
Description	Puromycin-sensitive aminopeptidase (EC 3.4.11.-) (PSA).

LAEVR_MOUSE
θ value	3.12697e-77 (rank : 13)	NC score	0.956629 (rank : 11)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	20
SwissProt Accessions	Q2KHK3, Q9D633	Gene names	Lvrn
Domain Architecture	No domain graphic available
Description	Laeverin (EC 3.4.-.-).

AMPB_MOUSE
θ value	1.058e-16 (rank : 14)	NC score	0.660337 (rank : 16)
Query Neighborhood Hits	49	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VCT3	Gene names	Rnpep
Domain Architecture
Description	Aminopeptidase B (EC 3.4.11.6) (Ap-B) (Arginyl aminopeptidase) (Arginine aminopeptidase) (Cytosol aminopeptidase IV).

LKHA4_HUMAN
θ value	1.80466e-16 (rank : 15)	NC score	0.694686 (rank : 14)
Query Neighborhood Hits	49	Target Neighborhood Hits	24	Shared Neighborhood Hits	20
SwissProt Accessions	P09960	Gene names	LTA4H, LTA4
Domain Architecture
Description	Leukotriene A-4 hydrolase (EC 3.3.2.6) (LTA-4 hydrolase) (Leukotriene A(4) hydrolase).

LKHA4_MOUSE
θ value	3.07829e-16 (rank : 16)	NC score	0.687743 (rank : 15)
Query Neighborhood Hits	49	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	P24527, Q8VDR8	Gene names	Lta4h
Domain Architecture
Description	Leukotriene A-4 hydrolase (EC 3.3.2.6) (LTA-4 hydrolase) (Leukotriene A(4) hydrolase).

AMPB_HUMAN
θ value	7.58209e-15 (rank : 17)	NC score	0.646686 (rank : 17)
Query Neighborhood Hits	49	Target Neighborhood Hits	28	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H4A4, Q9BVM9, Q9H1D4, Q9NPT7	Gene names	RNPEP, APB
Domain Architecture
Description	Aminopeptidase B (EC 3.4.11.6) (Ap-B) (Arginyl aminopeptidase) (Arginine aminopeptidase).

RNPL1_HUMAN
θ value	6.64225e-11 (rank : 18)	NC score	0.621329 (rank : 18)
Query Neighborhood Hits	49	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HAU8, Q96AC9, Q9H033, Q9NVD0	Gene names	RNPEPL1
Domain Architecture
Description	Arginyl aminopeptidase-like 1 (EC 3.4.11.-) (RNPEP-like protein).

AMPO_HUMAN
θ value	4.45536e-07 (rank : 19)	NC score	0.464158 (rank : 19)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	22
SwissProt Accessions	Q8N6M6, Q5T9B1, Q5T9B3, Q5T9B4, Q8WUL6, Q96M23, Q96SS1	Gene names	ONPEP, C9orf3
Domain Architecture	No domain graphic available
Description	Aminopeptidase O (EC 3.4.11.-) (AP-O).

AMPO_MOUSE
θ value	7.59969e-07 (rank : 20)	NC score	0.451339 (rank : 20)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BXQ6, Q6P0W6, Q6P394, Q8BHX5	Gene names	Onpep
Domain Architecture	No domain graphic available
Description	Aminopeptidase O (EC 3.4.11.-) (AP-O).

TAF2_HUMAN
θ value	0.163984 (rank : 21)	NC score	0.199704 (rank : 21)
Query Neighborhood Hits	49	Target Neighborhood Hits	36	Shared Neighborhood Hits	17
SwissProt Accessions	Q6P1X5, O43487, O43604, O60668, Q86WW7, Q8IWK4	Gene names	TAF2, CIF150, TAF2B
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 2 (Transcription initiation factor TFIID 150 kDa subunit) (TBP-associated factor 150 kDa) (TAFII-150) (TAFII150) (150 kDa cofactor of initiator function).

EDAD_HUMAN
θ value	0.365318 (rank : 22)	NC score	0.056175 (rank : 23)
Query Neighborhood Hits	49	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WWZ3, Q5VYJ7	Gene names	EDARADD
Domain Architecture	No domain graphic available
Description	Ectodysplasin A receptor-associated adapter protein (EDAR-associated death domain protein) (Crinkled homolog).

TAF2_MOUSE
θ value	0.365318 (rank : 23)	NC score	0.190569 (rank : 22)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C176, Q8BKQ7	Gene names	Taf2
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 2 (Transcription initiation factor TFIID 150 kDa subunit) (TBP-associated factor 150 kDa).

CO3A1_HUMAN
θ value	1.38821 (rank : 24)	NC score	0.025819 (rank : 24)
Query Neighborhood Hits	49	Target Neighborhood Hits	452	Shared Neighborhood Hits	15
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO3A1_MOUSE
θ value	1.38821 (rank : 25)	NC score	0.025745 (rank : 25)
Query Neighborhood Hits	49	Target Neighborhood Hits	466	Shared Neighborhood Hits	15
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO5A1_HUMAN
θ value	1.38821 (rank : 26)	NC score	0.023145 (rank : 27)
Query Neighborhood Hits	49	Target Neighborhood Hits	434	Shared Neighborhood Hits	15
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

CO5A1_MOUSE
θ value	1.38821 (rank : 27)	NC score	0.023186 (rank : 26)
Query Neighborhood Hits	49	Target Neighborhood Hits	419	Shared Neighborhood Hits	15
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

ROA3_HUMAN
θ value	1.81305 (rank : 28)	NC score	0.008284 (rank : 42)
Query Neighborhood Hits	49	Target Neighborhood Hits	198	Shared Neighborhood Hits	4
SwissProt Accessions	P51991, Q6URK5	Gene names	HNRPA3
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3).

ROA3_MOUSE
θ value	1.81305 (rank : 29)	NC score	0.008247 (rank : 43)
Query Neighborhood Hits	49	Target Neighborhood Hits	199	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BG05, Q8BHF8	Gene names	Hnrpa3, Hnrnpa3
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3).

PRIO_HUMAN
θ value	3.0926 (rank : 30)	NC score	0.018322 (rank : 30)
Query Neighborhood Hits	49	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P04156, O60489, P78446, Q15216, Q15221, Q8TBG0, Q96E70, Q9UP19	Gene names	PRNP, PRP
Domain Architecture
Description	Major prion protein precursor (PrP) (PrP27-30) (PrP33-35C) (ASCR) (CD230 antigen).

TCF20_MOUSE
θ value	3.0926 (rank : 31)	NC score	0.016872 (rank : 32)
Query Neighborhood Hits	49	Target Neighborhood Hits	396	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

CO1A1_MOUSE
θ value	4.03905 (rank : 32)	NC score	0.021770 (rank : 28)
Query Neighborhood Hits	49	Target Neighborhood Hits	457	Shared Neighborhood Hits	15
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CO4A2_MOUSE
θ value	4.03905 (rank : 33)	NC score	0.016624 (rank : 33)
Query Neighborhood Hits	49	Target Neighborhood Hits	492	Shared Neighborhood Hits	15
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

COBA1_HUMAN
θ value	4.03905 (rank : 34)	NC score	0.018791 (rank : 29)
Query Neighborhood Hits	49	Target Neighborhood Hits	491	Shared Neighborhood Hits	15
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

COBA1_MOUSE
θ value	4.03905 (rank : 35)	NC score	0.016339 (rank : 34)
Query Neighborhood Hits	49	Target Neighborhood Hits	487	Shared Neighborhood Hits	14
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

FBN2_HUMAN
θ value	4.03905 (rank : 36)	NC score	0.000705 (rank : 47)
Query Neighborhood Hits	49	Target Neighborhood Hits	560	Shared Neighborhood Hits	3
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

CITE2_HUMAN
θ value	5.27518 (rank : 37)	NC score	0.014740 (rank : 36)
Query Neighborhood Hits	49	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q99967, O95426	Gene names	CITED2, MRG1
Domain Architecture
Description	Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1) (P35srj).

CO2A1_HUMAN
θ value	5.27518 (rank : 38)	NC score	0.017921 (rank : 31)
Query Neighborhood Hits	49	Target Neighborhood Hits	486	Shared Neighborhood Hits	15
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CO4A5_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.013433 (rank : 39)
Query Neighborhood Hits	49	Target Neighborhood Hits	383	Shared Neighborhood Hits	15
SwissProt Accessions	P29400, Q16006, Q16126, Q6LD84	Gene names	COL4A5
Domain Architecture
Description	Collagen alpha-5(IV) chain precursor.

PSG9_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.004906 (rank : 45)
Query Neighborhood Hits	49	Target Neighborhood Hits	221	Shared Neighborhood Hits	3
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

IASPP_MOUSE
θ value	6.88961 (rank : 41)	NC score	0.003912 (rank : 46)
Query Neighborhood Hits	49	Target Neighborhood Hits	1024	Shared Neighborhood Hits	14
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

TCF20_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.014205 (rank : 38)
Query Neighborhood Hits	49	Target Neighborhood Hits	323	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

TPSN_MOUSE
θ value	6.88961 (rank : 43)	NC score	0.009595 (rank : 41)
Query Neighborhood Hits	49	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R233, O70317, Q91YE0, Q91YE1, Q9QWT7, Q9Z1W3	Gene names	Tapbp, Tapa
Domain Architecture
Description	Tapasin precursor (TPSN) (TPN) (TAP-binding protein) (TAP-associated protein).

CITE2_MOUSE
θ value	8.99809 (rank : 44)	NC score	0.012469 (rank : 40)
Query Neighborhood Hits	49	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	O35740, O35741, O35742, O35743, O55198	Gene names	Cited2, Mrg1, Msg2
Domain Architecture
Description	Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1).

CO4A1_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.016032 (rank : 35)
Query Neighborhood Hits	49	Target Neighborhood Hits	450	Shared Neighborhood Hits	19
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CO9A1_MOUSE
θ value	8.99809 (rank : 46)	NC score	0.014338 (rank : 37)
Query Neighborhood Hits	49	Target Neighborhood Hits	477	Shared Neighborhood Hits	18
SwissProt Accessions	Q05722, Q61269, Q61270, Q61433, Q61940	Gene names	Col9a1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

CUTL1_HUMAN
θ value	8.99809 (rank : 47)	NC score	-0.002400 (rank : 49)
Query Neighborhood Hits	49	Target Neighborhood Hits	1574	Shared Neighborhood Hits	2
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

NPT2C_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.004951 (rank : 44)
Query Neighborhood Hits	49	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N130	Gene names	SLC34A3, NPT2C, NPTIIC
Domain Architecture	No domain graphic available
Description	Sodium-dependent phosphate transport protein 2C (Sodium/phosphate cotransporter 2C) (Na(+)/Pi cotransporter 2C) (Sodium-phosphate transport protein 2C) (Na(+)-dependent phosphate cotransporter 2C) (NaPi-2c) (Sodium/inorganic phosphate cotransporter IIC) (Solute carrier family 34 member 3).

TAF5_MOUSE
θ value	8.99809 (rank : 49)	NC score	-0.000146 (rank : 48)
Query Neighborhood Hits	49	Target Neighborhood Hits	366	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C092, Q8BTR2	Gene names	Taf5
Domain Architecture
Description	Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100).

Hits sorted by NC score

TRHDE_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UKU6, Q6UWJ4	Gene names	TRHDE
Domain Architecture
Description	Thyrotropin-releasing hormone-degrading ectoenzyme (EC 3.4.19.6) (TRH- degrading ectoenzyme) (TRH-DE) (TRH-specific aminopeptidase) (Thyroliberinase) (Pyroglutamyl-peptidase II) (PAP-II).

TRHDE_MOUSE
NC score	0.998457 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	49	Target Neighborhood Hits	58	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K093	Gene names	Trhde
Domain Architecture	No domain graphic available
Description	Thyrotropin-releasing hormone-degrading ectoenzyme (EC 3.4.19.6) (TRH- degrading ectoenzyme) (TRH-DE) (TRH-specific aminopeptidase) (Thyroliberinase) (Pyroglutamyl-peptidase II) (PAP-II).

AMPN_HUMAN
NC score	0.975465 (rank : 3)	θ value	3.05528e-157 (rank : 3)
Query Neighborhood Hits	49	Target Neighborhood Hits	37	Shared Neighborhood Hits	22
SwissProt Accessions	P15144, Q16728, Q8IUK3, Q8IVH3, Q9UCE0	Gene names	ANPEP, APN, CD13, PEPN
Domain Architecture
Description	Aminopeptidase N (EC 3.4.11.2) (hAPN) (Alanyl aminopeptidase) (Microsomal aminopeptidase) (Aminopeptidase M) (gp150) (Myeloid plasma membrane glycoprotein CD13) (CD13 antigen).

AMPN_MOUSE
NC score	0.974876 (rank : 4)	θ value	1.46868e-151 (rank : 4)
Query Neighborhood Hits	49	Target Neighborhood Hits	34	Shared Neighborhood Hits	22
SwissProt Accessions	P97449, Q91YH8, Q99K63	Gene names	Anpep, Lap-1, Lap1
Domain Architecture
Description	Aminopeptidase N (EC 3.4.11.2) (mAPN) (Alanyl aminopeptidase) (Microsomal aminopeptidase) (Aminopeptidase M) (Membrane protein p161) (CD13 antigen).

AMPE_HUMAN
NC score	0.970483 (rank : 5)	θ value	6.18479e-142 (rank : 5)
Query Neighborhood Hits	49	Target Neighborhood Hits	46	Shared Neighborhood Hits	22
SwissProt Accessions	Q07075	Gene names	ENPEP
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (Differentiation antigen gp160) (CD249 antigen).

AMPE_MOUSE
NC score	0.969839 (rank : 6)	θ value	2.87295e-139 (rank : 7)
Query Neighborhood Hits	49	Target Neighborhood Hits	35	Shared Neighborhood Hits	22
SwissProt Accessions	P16406	Gene names	Enpep
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (BP-1/6C3 antigen).

LCAP_HUMAN
NC score	0.969045 (rank : 7)	θ value	2.61056e-124 (rank : 10)
Query Neighborhood Hits	49	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UIQ6, O00769, Q15145, Q9UIQ7	Gene names	LNPEP, OTASE
Domain Architecture
Description	Leucyl-cystinyl aminopeptidase (EC 3.4.11.3) (Cystinyl aminopeptidase) (Oxytocinase) (OTase) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Placental leucine aminopeptidase) (P-LAP).

ARTS1_MOUSE
NC score	0.968964 (rank : 8)	θ value	1.28961e-139 (rank : 6)
Query Neighborhood Hits	49	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q9EQH2, Q9ET63	Gene names	Arts1, Appils
Domain Architecture
Description	Adipocyte-derived leucine aminopeptidase precursor (EC 3.4.11.-) (A- LAP) (ARTS-1) (Aminopeptidase PILS) (Puromycin-insensitive leucyl- specific aminopeptidase) (PILS-AP) (VEGF-induced aminopeptidase).

ARTS1_HUMAN
NC score	0.968176 (rank : 9)	θ value	7.32286e-135 (rank : 8)
Query Neighborhood Hits	49	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZ08, O60278, Q6UWY6, Q8NEL4, Q8TAD0, Q9UHF8, Q9UKY2	Gene names	ARTS1, APPILS, KIAA0525
Domain Architecture
Description	Adipocyte-derived leucine aminopeptidase precursor (EC 3.4.11.-) (A- LAP) (ARTS-1) (Aminopeptidase PILS) (Puromycin-insensitive leucyl- specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator).

LAEVR_HUMAN
NC score	0.965564 (rank : 10)	θ value	3.5201e-129 (rank : 9)
Query Neighborhood Hits	49	Target Neighborhood Hits	73	Shared Neighborhood Hits	20
SwissProt Accessions	Q6Q4G3, Q32MR1, Q4G0I9, Q4G0V2, Q86XA3, Q8NBZ2	Gene names	LVRN
Domain Architecture	No domain graphic available
Description	Laeverin (EC 3.4.-.-) (CHL2 antigen).

LAEVR_MOUSE
NC score	0.956629 (rank : 11)	θ value	3.12697e-77 (rank : 13)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	20
SwissProt Accessions	Q2KHK3, Q9D633	Gene names	Lvrn
Domain Architecture	No domain graphic available
Description	Laeverin (EC 3.4.-.-).

PSA_HUMAN
NC score	0.956285 (rank : 12)	θ value	1.87955e-106 (rank : 11)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	22
SwissProt Accessions	P55786, Q6P145, Q9NP16, Q9UEM2	Gene names	NPEPPS, PSA
Domain Architecture
Description	Puromycin-sensitive aminopeptidase (EC 3.4.11.-) (PSA).

PSA_MOUSE
NC score	0.956134 (rank : 13)	θ value	2.71407e-105 (rank : 12)
Query Neighborhood Hits	49	Target Neighborhood Hits	32	Shared Neighborhood Hits	22
SwissProt Accessions	Q11011, Q91VJ8	Gene names	Npepps, Psa
Domain Architecture
Description	Puromycin-sensitive aminopeptidase (EC 3.4.11.-) (PSA).

LKHA4_HUMAN
NC score	0.694686 (rank : 14)	θ value	1.80466e-16 (rank : 15)
Query Neighborhood Hits	49	Target Neighborhood Hits	24	Shared Neighborhood Hits	20
SwissProt Accessions	P09960	Gene names	LTA4H, LTA4
Domain Architecture
Description	Leukotriene A-4 hydrolase (EC 3.3.2.6) (LTA-4 hydrolase) (Leukotriene A(4) hydrolase).

LKHA4_MOUSE
NC score	0.687743 (rank : 15)	θ value	3.07829e-16 (rank : 16)
Query Neighborhood Hits	49	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	P24527, Q8VDR8	Gene names	Lta4h
Domain Architecture
Description	Leukotriene A-4 hydrolase (EC 3.3.2.6) (LTA-4 hydrolase) (Leukotriene A(4) hydrolase).

AMPB_MOUSE
NC score	0.660337 (rank : 16)	θ value	1.058e-16 (rank : 14)
Query Neighborhood Hits	49	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VCT3	Gene names	Rnpep
Domain Architecture
Description	Aminopeptidase B (EC 3.4.11.6) (Ap-B) (Arginyl aminopeptidase) (Arginine aminopeptidase) (Cytosol aminopeptidase IV).

AMPB_HUMAN
NC score	0.646686 (rank : 17)	θ value	7.58209e-15 (rank : 17)
Query Neighborhood Hits	49	Target Neighborhood Hits	28	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H4A4, Q9BVM9, Q9H1D4, Q9NPT7	Gene names	RNPEP, APB
Domain Architecture
Description	Aminopeptidase B (EC 3.4.11.6) (Ap-B) (Arginyl aminopeptidase) (Arginine aminopeptidase).

RNPL1_HUMAN
NC score	0.621329 (rank : 18)	θ value	6.64225e-11 (rank : 18)
Query Neighborhood Hits	49	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HAU8, Q96AC9, Q9H033, Q9NVD0	Gene names	RNPEPL1
Domain Architecture
Description	Arginyl aminopeptidase-like 1 (EC 3.4.11.-) (RNPEP-like protein).

AMPO_HUMAN
NC score	0.464158 (rank : 19)	θ value	4.45536e-07 (rank : 19)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	22
SwissProt Accessions	Q8N6M6, Q5T9B1, Q5T9B3, Q5T9B4, Q8WUL6, Q96M23, Q96SS1	Gene names	ONPEP, C9orf3
Domain Architecture	No domain graphic available
Description	Aminopeptidase O (EC 3.4.11.-) (AP-O).

AMPO_MOUSE
NC score	0.451339 (rank : 20)	θ value	7.59969e-07 (rank : 20)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BXQ6, Q6P0W6, Q6P394, Q8BHX5	Gene names	Onpep
Domain Architecture	No domain graphic available
Description	Aminopeptidase O (EC 3.4.11.-) (AP-O).

TAF2_HUMAN
NC score	0.199704 (rank : 21)	θ value	0.163984 (rank : 21)
Query Neighborhood Hits	49	Target Neighborhood Hits	36	Shared Neighborhood Hits	17
SwissProt Accessions	Q6P1X5, O43487, O43604, O60668, Q86WW7, Q8IWK4	Gene names	TAF2, CIF150, TAF2B
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 2 (Transcription initiation factor TFIID 150 kDa subunit) (TBP-associated factor 150 kDa) (TAFII-150) (TAFII150) (150 kDa cofactor of initiator function).

TAF2_MOUSE
NC score	0.190569 (rank : 22)	θ value	0.365318 (rank : 23)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C176, Q8BKQ7	Gene names	Taf2
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 2 (Transcription initiation factor TFIID 150 kDa subunit) (TBP-associated factor 150 kDa).

EDAD_HUMAN
NC score	0.056175 (rank : 23)	θ value	0.365318 (rank : 22)
Query Neighborhood Hits	49	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WWZ3, Q5VYJ7	Gene names	EDARADD
Domain Architecture	No domain graphic available
Description	Ectodysplasin A receptor-associated adapter protein (EDAR-associated death domain protein) (Crinkled homolog).

CO3A1_HUMAN
NC score	0.025819 (rank : 24)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	49	Target Neighborhood Hits	452	Shared Neighborhood Hits	15
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO3A1_MOUSE
NC score	0.025745 (rank : 25)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	49	Target Neighborhood Hits	466	Shared Neighborhood Hits	15
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO5A1_MOUSE
NC score	0.023186 (rank : 26)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	49	Target Neighborhood Hits	419	Shared Neighborhood Hits	15
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

CO5A1_HUMAN
NC score	0.023145 (rank : 27)	θ value	1.38821 (rank : 26)
Query Neighborhood Hits	49	Target Neighborhood Hits	434	Shared Neighborhood Hits	15
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

CO1A1_MOUSE
NC score	0.021770 (rank : 28)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	49	Target Neighborhood Hits	457	Shared Neighborhood Hits	15
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

COBA1_HUMAN
NC score	0.018791 (rank : 29)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	49	Target Neighborhood Hits	491	Shared Neighborhood Hits	15
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

PRIO_HUMAN
NC score	0.018322 (rank : 30)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	49	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P04156, O60489, P78446, Q15216, Q15221, Q8TBG0, Q96E70, Q9UP19	Gene names	PRNP, PRP
Domain Architecture
Description	Major prion protein precursor (PrP) (PrP27-30) (PrP33-35C) (ASCR) (CD230 antigen).

CO2A1_HUMAN
NC score	0.017921 (rank : 31)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	49	Target Neighborhood Hits	486	Shared Neighborhood Hits	15
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

TCF20_MOUSE
NC score	0.016872 (rank : 32)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	49	Target Neighborhood Hits	396	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

CO4A2_MOUSE
NC score	0.016624 (rank : 33)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	49	Target Neighborhood Hits	492	Shared Neighborhood Hits	15
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

COBA1_MOUSE
NC score	0.016339 (rank : 34)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	49	Target Neighborhood Hits	487	Shared Neighborhood Hits	14
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

CO4A1_MOUSE
NC score	0.016032 (rank : 35)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	49	Target Neighborhood Hits	450	Shared Neighborhood Hits	19
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CITE2_HUMAN
NC score	0.014740 (rank : 36)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	49	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q99967, O95426	Gene names	CITED2, MRG1
Domain Architecture
Description	Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1) (P35srj).

CO9A1_MOUSE
NC score	0.014338 (rank : 37)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	49	Target Neighborhood Hits	477	Shared Neighborhood Hits	18
SwissProt Accessions	Q05722, Q61269, Q61270, Q61433, Q61940	Gene names	Col9a1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

TCF20_HUMAN
NC score	0.014205 (rank : 38)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	49	Target Neighborhood Hits	323	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

CO4A5_HUMAN
NC score	0.013433 (rank : 39)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	49	Target Neighborhood Hits	383	Shared Neighborhood Hits	15
SwissProt Accessions	P29400, Q16006, Q16126, Q6LD84	Gene names	COL4A5
Domain Architecture
Description	Collagen alpha-5(IV) chain precursor.

CITE2_MOUSE
NC score	0.012469 (rank : 40)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	49	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	O35740, O35741, O35742, O35743, O55198	Gene names	Cited2, Mrg1, Msg2
Domain Architecture
Description	Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1).

TPSN_MOUSE
NC score	0.009595 (rank : 41)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	49	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R233, O70317, Q91YE0, Q91YE1, Q9QWT7, Q9Z1W3	Gene names	Tapbp, Tapa
Domain Architecture
Description	Tapasin precursor (TPSN) (TPN) (TAP-binding protein) (TAP-associated protein).

ROA3_HUMAN
NC score	0.008284 (rank : 42)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	49	Target Neighborhood Hits	198	Shared Neighborhood Hits	4
SwissProt Accessions	P51991, Q6URK5	Gene names	HNRPA3
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3).

ROA3_MOUSE
NC score	0.008247 (rank : 43)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	49	Target Neighborhood Hits	199	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BG05, Q8BHF8	Gene names	Hnrpa3, Hnrnpa3
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3).

NPT2C_HUMAN
NC score	0.004951 (rank : 44)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	49	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N130	Gene names	SLC34A3, NPT2C, NPTIIC
Domain Architecture	No domain graphic available
Description	Sodium-dependent phosphate transport protein 2C (Sodium/phosphate cotransporter 2C) (Na(+)/Pi cotransporter 2C) (Sodium-phosphate transport protein 2C) (Na(+)-dependent phosphate cotransporter 2C) (NaPi-2c) (Sodium/inorganic phosphate cotransporter IIC) (Solute carrier family 34 member 3).

PSG9_HUMAN
NC score	0.004906 (rank : 45)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	49	Target Neighborhood Hits	221	Shared Neighborhood Hits	3
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

IASPP_MOUSE
NC score	0.003912 (rank : 46)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	49	Target Neighborhood Hits	1024	Shared Neighborhood Hits	14
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

FBN2_HUMAN
NC score	0.000705 (rank : 47)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	49	Target Neighborhood Hits	560	Shared Neighborhood Hits	3
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

TAF5_MOUSE
NC score	-0.000146 (rank : 48)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	49	Target Neighborhood Hits	366	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C092, Q8BTR2	Gene names	Taf5
Domain Architecture
Description	Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100).

CUTL1_HUMAN
NC score	-0.002400 (rank : 49)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	49	Target Neighborhood Hits	1574	Shared Neighborhood Hits	2
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).