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Network neighborhood for query Sequence : AP2B1_HUMAN

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AP2B1_HUMAN
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AP1B1_HUMAN
θ value	0 (rank : 1)	NC score	0.997125 (rank : 3)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	42
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_MOUSE
θ value	0 (rank : 2)	NC score	0.996343 (rank : 4)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	44
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP2B1_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	59
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_MOUSE
θ value	0 (rank : 4)	NC score	0.999941 (rank : 2)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	58
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP4B1_MOUSE
θ value	5.15425e-80 (rank : 5)	NC score	0.891964 (rank : 5)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_HUMAN
θ value	3.69378e-78 (rank : 6)	NC score	0.885518 (rank : 6)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP3B1_MOUSE
θ value	4.67263e-73 (rank : 7)	NC score	0.806442 (rank : 7)
Query Neighborhood Hits	59	Target Neighborhood Hits	302	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B1_HUMAN
θ value	5.1662e-72 (rank : 8)	NC score	0.805576 (rank : 8)
Query Neighborhood Hits	59	Target Neighborhood Hits	283	Shared Neighborhood Hits	23
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B2_MOUSE
θ value	6.7473e-72 (rank : 9)	NC score	0.801767 (rank : 10)
Query Neighborhood Hits	59	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

AP3B2_HUMAN
θ value	4.37348e-71 (rank : 10)	NC score	0.803242 (rank : 9)
Query Neighborhood Hits	59	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP2A2_HUMAN
θ value	1.02238e-19 (rank : 11)	NC score	0.500624 (rank : 17)
Query Neighborhood Hits	59	Target Neighborhood Hits	39	Shared Neighborhood Hits	18
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP2A2_MOUSE
θ value	2.27762e-19 (rank : 12)	NC score	0.499275 (rank : 19)
Query Neighborhood Hits	59	Target Neighborhood Hits	46	Shared Neighborhood Hits	18
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP3D1_MOUSE
θ value	2.13179e-17 (rank : 13)	NC score	0.575650 (rank : 11)
Query Neighborhood Hits	59	Target Neighborhood Hits	144	Shared Neighborhood Hits	29
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP2A1_MOUSE
θ value	6.20254e-17 (rank : 14)	NC score	0.473435 (rank : 21)
Query Neighborhood Hits	59	Target Neighborhood Hits	57	Shared Neighborhood Hits	18
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_HUMAN
θ value	8.10077e-17 (rank : 15)	NC score	0.476148 (rank : 20)
Query Neighborhood Hits	59	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP3D1_HUMAN
θ value	1.16975e-15 (rank : 16)	NC score	0.551432 (rank : 12)
Query Neighborhood Hits	59	Target Neighborhood Hits	254	Shared Neighborhood Hits	30
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

AP1G1_HUMAN
θ value	4.16044e-13 (rank : 17)	NC score	0.509262 (rank : 16)
Query Neighborhood Hits	59	Target Neighborhood Hits	65	Shared Neighborhood Hits	29
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_MOUSE
θ value	4.16044e-13 (rank : 18)	NC score	0.510242 (rank : 15)
Query Neighborhood Hits	59	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

COPB_HUMAN
θ value	4.59992e-12 (rank : 19)	NC score	0.532967 (rank : 13)
Query Neighborhood Hits	59	Target Neighborhood Hits	47	Shared Neighborhood Hits	23
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_MOUSE
θ value	4.59992e-12 (rank : 20)	NC score	0.532808 (rank : 14)
Query Neighborhood Hits	59	Target Neighborhood Hits	50	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPG2_MOUSE
θ value	1.133e-10 (rank : 21)	NC score	0.412281 (rank : 25)
Query Neighborhood Hits	59	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG2_HUMAN
θ value	1.47974e-10 (rank : 22)	NC score	0.408062 (rank : 26)
Query Neighborhood Hits	59	Target Neighborhood Hits	33	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG_HUMAN
θ value	1.25267e-09 (rank : 23)	NC score	0.370401 (rank : 27)
Query Neighborhood Hits	59	Target Neighborhood Hits	31	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

AP1G2_MOUSE
θ value	2.13673e-09 (rank : 24)	NC score	0.500511 (rank : 18)
Query Neighborhood Hits	59	Target Neighborhood Hits	52	Shared Neighborhood Hits	27
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP4E1_HUMAN
θ value	8.97725e-08 (rank : 25)	NC score	0.458027 (rank : 22)
Query Neighborhood Hits	59	Target Neighborhood Hits	57	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP4E1_MOUSE
θ value	2.61198e-07 (rank : 26)	NC score	0.453651 (rank : 24)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	25
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP1G2_HUMAN
θ value	3.41135e-07 (rank : 27)	NC score	0.455225 (rank : 23)
Query Neighborhood Hits	59	Target Neighborhood Hits	44	Shared Neighborhood Hits	26
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

SPAG6_MOUSE
θ value	0.0961366 (rank : 28)	NC score	0.086042 (rank : 30)
Query Neighborhood Hits	59	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JLI7, Q8K461	Gene names	Spag6, Pf16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Axoneme central apparatus protein).

K0056_MOUSE
θ value	0.125558 (rank : 29)	NC score	0.086051 (rank : 29)
Query Neighborhood Hits	59	Target Neighborhood Hits	67	Shared Neighborhood Hits	11
SwissProt Accessions	Q6ZQK0, Q9CS21	Gene names	Kiaa0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

SPAG6_HUMAN
θ value	0.125558 (rank : 30)	NC score	0.097830 (rank : 28)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

EVPL_HUMAN
θ value	0.163984 (rank : 31)	NC score	0.022008 (rank : 43)
Query Neighborhood Hits	59	Target Neighborhood Hits	895	Shared Neighborhood Hits	9
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

EVPL_MOUSE
θ value	0.21417 (rank : 32)	NC score	0.030124 (rank : 40)
Query Neighborhood Hits	59	Target Neighborhood Hits	952	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

MBB1A_HUMAN
θ value	0.21417 (rank : 33)	NC score	0.032582 (rank : 39)
Query Neighborhood Hits	59	Target Neighborhood Hits	665	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

K0056_HUMAN
θ value	0.279714 (rank : 34)	NC score	0.080319 (rank : 31)
Query Neighborhood Hits	59	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	P42695	Gene names	KIAA0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

TRIM7_HUMAN
θ value	0.365318 (rank : 35)	NC score	0.025767 (rank : 41)
Query Neighborhood Hits	59	Target Neighborhood Hits	336	Shared Neighborhood Hits	7
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

RRP5_HUMAN
θ value	0.62314 (rank : 36)	NC score	0.051549 (rank : 32)
Query Neighborhood Hits	59	Target Neighborhood Hits	291	Shared Neighborhood Hits	6
SwissProt Accessions	Q14690, Q86VQ8	Gene names	PDCD11, KIAA0185
Domain Architecture
Description	RRP5 protein homolog (Programmed cell death protein 11).

PON2_HUMAN
θ value	1.06291 (rank : 37)	NC score	0.022793 (rank : 42)
Query Neighborhood Hits	59	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q15165, O15114, O15115, O75856, Q86YL0	Gene names	PON2
Domain Architecture
Description	Serum paraoxonase/arylesterase 2 (EC 3.1.1.2) (EC 3.1.8.1) (PON 2) (Serum aryldialkylphosphatase 2) (A-esterase 2) (Aromatic esterase 2).

RPTOR_HUMAN
θ value	1.81305 (rank : 38)	NC score	0.049339 (rank : 36)
Query Neighborhood Hits	59	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N122, Q8N4V9, Q8TB32, Q9P2P3	Gene names	RAPTOR, KIAA1303
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

SPTB2_HUMAN
θ value	1.81305 (rank : 39)	NC score	0.015007 (rank : 50)
Query Neighborhood Hits	59	Target Neighborhood Hits	748	Shared Neighborhood Hits	10
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	1.81305 (rank : 40)	NC score	0.014786 (rank : 51)
Query Neighborhood Hits	59	Target Neighborhood Hits	770	Shared Neighborhood Hits	10
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TRIM7_MOUSE
θ value	1.81305 (rank : 41)	NC score	0.017911 (rank : 47)
Query Neighborhood Hits	59	Target Neighborhood Hits	358	Shared Neighborhood Hits	6
SwissProt Accessions	Q923T7, Q5NCB6, Q99PQ5	Gene names	Trim7, Gnip
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein).

UB2R1_HUMAN
θ value	1.81305 (rank : 42)	NC score	0.017928 (rank : 45)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	4
SwissProt Accessions	P49427	Gene names	CDC34, UBE2R1
Domain Architecture
Description	Ubiquitin-conjugating enzyme E2-32 kDa complementing (EC 6.3.2.19) (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (E2-CDC34).

UB2R1_MOUSE
θ value	1.81305 (rank : 43)	NC score	0.017921 (rank : 46)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CFI2, Q505K8	Gene names	Cdc34
Domain Architecture
Description	Ubiquitin-conjugating enzyme E2-32 kDa complementing (EC 6.3.2.19) (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (E2-CDC34).

DYH5_MOUSE
θ value	2.36792 (rank : 44)	NC score	0.019156 (rank : 44)
Query Neighborhood Hits	59	Target Neighborhood Hits	286	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VHE6, Q8BWG1	Gene names	Dnah5, Dnahc5
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (Mdnah5).

RPTOR_MOUSE
θ value	3.0926 (rank : 45)	NC score	0.044601 (rank : 37)
Query Neighborhood Hits	59	Target Neighborhood Hits	129	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K4Q0, Q8C9W9, Q8CBY4, Q8CDY8, Q9D4H3	Gene names	Raptor
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

ARMC4_HUMAN
θ value	4.03905 (rank : 46)	NC score	0.036830 (rank : 38)
Query Neighborhood Hits	59	Target Neighborhood Hits	88	Shared Neighborhood Hits	7
SwissProt Accessions	Q5T2S8, Q9H0C0	Gene names	ARMC4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 4.

SALL3_HUMAN
θ value	4.03905 (rank : 47)	NC score	-0.000397 (rank : 61)
Query Neighborhood Hits	59	Target Neighborhood Hits	1066	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

DOCK8_HUMAN
θ value	5.27518 (rank : 48)	NC score	0.009206 (rank : 56)
Query Neighborhood Hits	59	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NF50, Q3MV16, Q5JPJ1, Q8TEP1, Q8WUY2, Q9BYJ5, Q9H1Q2, Q9H1Q3, Q9H308, Q9H7P2	Gene names	DOCK8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

GGA2_MOUSE
θ value	5.27518 (rank : 49)	NC score	0.049631 (rank : 35)
Query Neighborhood Hits	59	Target Neighborhood Hits	60	Shared Neighborhood Hits	7
SwissProt Accessions	Q6P5E6, Q3U374, Q6PFX3, Q6ZPY8, Q8BM76, Q9DC15	Gene names	Gga2, Kiaa1080
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2).

COKA1_HUMAN
θ value	6.88961 (rank : 50)	NC score	0.003451 (rank : 58)
Query Neighborhood Hits	59	Target Neighborhood Hits	403	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

HAIR_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.006153 (rank : 57)
Query Neighborhood Hits	59	Target Neighborhood Hits	172	Shared Neighborhood Hits	3
SwissProt Accessions	O43593, Q96H33, Q9NPE1	Gene names	HR
Domain Architecture
Description	Protein hairless.

IL5RA_HUMAN
θ value	6.88961 (rank : 52)	NC score	0.012670 (rank : 53)
Query Neighborhood Hits	59	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q01344, Q6ISX9	Gene names	IL5RA, IL5R
Domain Architecture	No domain graphic available
Description	Interleukin-5 receptor alpha chain precursor (IL-5R-alpha) (CD125 antigen) (CDw125).

NF1_HUMAN
θ value	6.88961 (rank : 53)	NC score	0.015840 (rank : 48)
Query Neighborhood Hits	59	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

NF1_MOUSE
θ value	6.88961 (rank : 54)	NC score	0.015791 (rank : 49)
Query Neighborhood Hits	59	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

PK3CA_MOUSE
θ value	6.88961 (rank : 55)	NC score	0.014139 (rank : 52)
Query Neighborhood Hits	59	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

CEP63_HUMAN
θ value	8.99809 (rank : 56)	NC score	0.002602 (rank : 59)
Query Neighborhood Hits	59	Target Neighborhood Hits	1005	Shared Neighborhood Hits	8
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

IPO4_MOUSE
θ value	8.99809 (rank : 57)	NC score	0.009213 (rank : 55)
Query Neighborhood Hits	59	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VI75, Q3TBW0, Q99J52	Gene names	Ipo4, Imp4a, Ranbp4
Domain Architecture	No domain graphic available
Description	Importin-4 (Importin 4a) (Imp4a) (Ran-binding protein 4) (RanBP4).

LAMA3_MOUSE
θ value	8.99809 (rank : 58)	NC score	0.001102 (rank : 60)
Query Neighborhood Hits	59	Target Neighborhood Hits	859	Shared Neighborhood Hits	8
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

PK3CA_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.012527 (rank : 54)
Query Neighborhood Hits	59	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

IWS1_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.051357 (rank : 33)
Query Neighborhood Hits	59	Target Neighborhood Hits	1241	Shared Neighborhood Hits	11
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

IWS1_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.050943 (rank : 34)
Query Neighborhood Hits	59	Target Neighborhood Hits	1258	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

Hits sorted by NC score

AP2B1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	59
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_MOUSE
NC score	0.999941 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	58
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP1B1_HUMAN
NC score	0.997125 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	42
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_MOUSE
NC score	0.996343 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	44
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP4B1_MOUSE
NC score	0.891964 (rank : 5)	θ value	5.15425e-80 (rank : 5)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_HUMAN
NC score	0.885518 (rank : 6)	θ value	3.69378e-78 (rank : 6)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP3B1_MOUSE
NC score	0.806442 (rank : 7)	θ value	4.67263e-73 (rank : 7)
Query Neighborhood Hits	59	Target Neighborhood Hits	302	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B1_HUMAN
NC score	0.805576 (rank : 8)	θ value	5.1662e-72 (rank : 8)
Query Neighborhood Hits	59	Target Neighborhood Hits	283	Shared Neighborhood Hits	23
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B2_HUMAN
NC score	0.803242 (rank : 9)	θ value	4.37348e-71 (rank : 10)
Query Neighborhood Hits	59	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP3B2_MOUSE
NC score	0.801767 (rank : 10)	θ value	6.7473e-72 (rank : 9)
Query Neighborhood Hits	59	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

AP3D1_MOUSE
NC score	0.575650 (rank : 11)	θ value	2.13179e-17 (rank : 13)
Query Neighborhood Hits	59	Target Neighborhood Hits	144	Shared Neighborhood Hits	29
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP3D1_HUMAN
NC score	0.551432 (rank : 12)	θ value	1.16975e-15 (rank : 16)
Query Neighborhood Hits	59	Target Neighborhood Hits	254	Shared Neighborhood Hits	30
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

COPB_HUMAN
NC score	0.532967 (rank : 13)	θ value	4.59992e-12 (rank : 19)
Query Neighborhood Hits	59	Target Neighborhood Hits	47	Shared Neighborhood Hits	23
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_MOUSE
NC score	0.532808 (rank : 14)	θ value	4.59992e-12 (rank : 20)
Query Neighborhood Hits	59	Target Neighborhood Hits	50	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

AP1G1_MOUSE
NC score	0.510242 (rank : 15)	θ value	4.16044e-13 (rank : 18)
Query Neighborhood Hits	59	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_HUMAN
NC score	0.509262 (rank : 16)	θ value	4.16044e-13 (rank : 17)
Query Neighborhood Hits	59	Target Neighborhood Hits	65	Shared Neighborhood Hits	29
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP2A2_HUMAN
NC score	0.500624 (rank : 17)	θ value	1.02238e-19 (rank : 11)
Query Neighborhood Hits	59	Target Neighborhood Hits	39	Shared Neighborhood Hits	18
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP1G2_MOUSE
NC score	0.500511 (rank : 18)	θ value	2.13673e-09 (rank : 24)
Query Neighborhood Hits	59	Target Neighborhood Hits	52	Shared Neighborhood Hits	27
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP2A2_MOUSE
NC score	0.499275 (rank : 19)	θ value	2.27762e-19 (rank : 12)
Query Neighborhood Hits	59	Target Neighborhood Hits	46	Shared Neighborhood Hits	18
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP2A1_HUMAN
NC score	0.476148 (rank : 20)	θ value	8.10077e-17 (rank : 15)
Query Neighborhood Hits	59	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_MOUSE
NC score	0.473435 (rank : 21)	θ value	6.20254e-17 (rank : 14)
Query Neighborhood Hits	59	Target Neighborhood Hits	57	Shared Neighborhood Hits	18
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP4E1_HUMAN
NC score	0.458027 (rank : 22)	θ value	8.97725e-08 (rank : 25)
Query Neighborhood Hits	59	Target Neighborhood Hits	57	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP1G2_HUMAN
NC score	0.455225 (rank : 23)	θ value	3.41135e-07 (rank : 27)
Query Neighborhood Hits	59	Target Neighborhood Hits	44	Shared Neighborhood Hits	26
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP4E1_MOUSE
NC score	0.453651 (rank : 24)	θ value	2.61198e-07 (rank : 26)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	25
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

COPG2_MOUSE
NC score	0.412281 (rank : 25)	θ value	1.133e-10 (rank : 21)
Query Neighborhood Hits	59	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG2_HUMAN
NC score	0.408062 (rank : 26)	θ value	1.47974e-10 (rank : 22)
Query Neighborhood Hits	59	Target Neighborhood Hits	33	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG_HUMAN
NC score	0.370401 (rank : 27)	θ value	1.25267e-09 (rank : 23)
Query Neighborhood Hits	59	Target Neighborhood Hits	31	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

SPAG6_HUMAN
NC score	0.097830 (rank : 28)	θ value	0.125558 (rank : 30)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

K0056_MOUSE
NC score	0.086051 (rank : 29)	θ value	0.125558 (rank : 29)
Query Neighborhood Hits	59	Target Neighborhood Hits	67	Shared Neighborhood Hits	11
SwissProt Accessions	Q6ZQK0, Q9CS21	Gene names	Kiaa0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

SPAG6_MOUSE
NC score	0.086042 (rank : 30)	θ value	0.0961366 (rank : 28)
Query Neighborhood Hits	59	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JLI7, Q8K461	Gene names	Spag6, Pf16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Axoneme central apparatus protein).

K0056_HUMAN
NC score	0.080319 (rank : 31)	θ value	0.279714 (rank : 34)
Query Neighborhood Hits	59	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	P42695	Gene names	KIAA0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

RRP5_HUMAN
NC score	0.051549 (rank : 32)	θ value	0.62314 (rank : 36)
Query Neighborhood Hits	59	Target Neighborhood Hits	291	Shared Neighborhood Hits	6
SwissProt Accessions	Q14690, Q86VQ8	Gene names	PDCD11, KIAA0185
Domain Architecture
Description	RRP5 protein homolog (Programmed cell death protein 11).

IWS1_HUMAN
NC score	0.051357 (rank : 33)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	59	Target Neighborhood Hits	1241	Shared Neighborhood Hits	11
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

IWS1_MOUSE
NC score	0.050943 (rank : 34)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	59	Target Neighborhood Hits	1258	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

GGA2_MOUSE
NC score	0.049631 (rank : 35)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	59	Target Neighborhood Hits	60	Shared Neighborhood Hits	7
SwissProt Accessions	Q6P5E6, Q3U374, Q6PFX3, Q6ZPY8, Q8BM76, Q9DC15	Gene names	Gga2, Kiaa1080
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2).

RPTOR_HUMAN
NC score	0.049339 (rank : 36)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	59	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N122, Q8N4V9, Q8TB32, Q9P2P3	Gene names	RAPTOR, KIAA1303
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

RPTOR_MOUSE
NC score	0.044601 (rank : 37)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	59	Target Neighborhood Hits	129	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K4Q0, Q8C9W9, Q8CBY4, Q8CDY8, Q9D4H3	Gene names	Raptor
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

ARMC4_HUMAN
NC score	0.036830 (rank : 38)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	59	Target Neighborhood Hits	88	Shared Neighborhood Hits	7
SwissProt Accessions	Q5T2S8, Q9H0C0	Gene names	ARMC4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 4.

MBB1A_HUMAN
NC score	0.032582 (rank : 39)	θ value	0.21417 (rank : 33)
Query Neighborhood Hits	59	Target Neighborhood Hits	665	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

EVPL_MOUSE
NC score	0.030124 (rank : 40)	θ value	0.21417 (rank : 32)
Query Neighborhood Hits	59	Target Neighborhood Hits	952	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

TRIM7_HUMAN
NC score	0.025767 (rank : 41)	θ value	0.365318 (rank : 35)
Query Neighborhood Hits	59	Target Neighborhood Hits	336	Shared Neighborhood Hits	7
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

PON2_HUMAN
NC score	0.022793 (rank : 42)	θ value	1.06291 (rank : 37)
Query Neighborhood Hits	59	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q15165, O15114, O15115, O75856, Q86YL0	Gene names	PON2
Domain Architecture
Description	Serum paraoxonase/arylesterase 2 (EC 3.1.1.2) (EC 3.1.8.1) (PON 2) (Serum aryldialkylphosphatase 2) (A-esterase 2) (Aromatic esterase 2).

EVPL_HUMAN
NC score	0.022008 (rank : 43)	θ value	0.163984 (rank : 31)
Query Neighborhood Hits	59	Target Neighborhood Hits	895	Shared Neighborhood Hits	9
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

DYH5_MOUSE
NC score	0.019156 (rank : 44)	θ value	2.36792 (rank : 44)
Query Neighborhood Hits	59	Target Neighborhood Hits	286	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VHE6, Q8BWG1	Gene names	Dnah5, Dnahc5
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (Mdnah5).

UB2R1_HUMAN
NC score	0.017928 (rank : 45)	θ value	1.81305 (rank : 42)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	4
SwissProt Accessions	P49427	Gene names	CDC34, UBE2R1
Domain Architecture
Description	Ubiquitin-conjugating enzyme E2-32 kDa complementing (EC 6.3.2.19) (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (E2-CDC34).

UB2R1_MOUSE
NC score	0.017921 (rank : 46)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CFI2, Q505K8	Gene names	Cdc34
Domain Architecture
Description	Ubiquitin-conjugating enzyme E2-32 kDa complementing (EC 6.3.2.19) (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (E2-CDC34).

TRIM7_MOUSE
NC score	0.017911 (rank : 47)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	59	Target Neighborhood Hits	358	Shared Neighborhood Hits	6
SwissProt Accessions	Q923T7, Q5NCB6, Q99PQ5	Gene names	Trim7, Gnip
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein).

NF1_HUMAN
NC score	0.015840 (rank : 48)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	59	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

NF1_MOUSE
NC score	0.015791 (rank : 49)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	59	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

SPTB2_HUMAN
NC score	0.015007 (rank : 50)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	59	Target Neighborhood Hits	748	Shared Neighborhood Hits	10
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
NC score	0.014786 (rank : 51)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	59	Target Neighborhood Hits	770	Shared Neighborhood Hits	10
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

PK3CA_MOUSE
NC score	0.014139 (rank : 52)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	59	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

IL5RA_HUMAN
NC score	0.012670 (rank : 53)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	59	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q01344, Q6ISX9	Gene names	IL5RA, IL5R
Domain Architecture	No domain graphic available
Description	Interleukin-5 receptor alpha chain precursor (IL-5R-alpha) (CD125 antigen) (CDw125).

PK3CA_HUMAN
NC score	0.012527 (rank : 54)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	59	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

IPO4_MOUSE
NC score	0.009213 (rank : 55)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	59	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VI75, Q3TBW0, Q99J52	Gene names	Ipo4, Imp4a, Ranbp4
Domain Architecture	No domain graphic available
Description	Importin-4 (Importin 4a) (Imp4a) (Ran-binding protein 4) (RanBP4).

DOCK8_HUMAN
NC score	0.009206 (rank : 56)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	59	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NF50, Q3MV16, Q5JPJ1, Q8TEP1, Q8WUY2, Q9BYJ5, Q9H1Q2, Q9H1Q3, Q9H308, Q9H7P2	Gene names	DOCK8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

HAIR_HUMAN
NC score	0.006153 (rank : 57)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	59	Target Neighborhood Hits	172	Shared Neighborhood Hits	3
SwissProt Accessions	O43593, Q96H33, Q9NPE1	Gene names	HR
Domain Architecture
Description	Protein hairless.

COKA1_HUMAN
NC score	0.003451 (rank : 58)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	59	Target Neighborhood Hits	403	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

CEP63_HUMAN
NC score	0.002602 (rank : 59)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	59	Target Neighborhood Hits	1005	Shared Neighborhood Hits	8
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

LAMA3_MOUSE
NC score	0.001102 (rank : 60)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	59	Target Neighborhood Hits	859	Shared Neighborhood Hits	8
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

SALL3_HUMAN
NC score	-0.000397 (rank : 61)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	59	Target Neighborhood Hits	1066	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).