Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : AP4B1_MOUSE

For an explanation of this page, click here

AP4B1_MOUSE
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AP4B1_HUMAN
θ value	0 (rank : 1)	NC score	0.995354 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP2B1_HUMAN
θ value	5.15425e-80 (rank : 3)	NC score	0.891964 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	27
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_MOUSE
θ value	5.15425e-80 (rank : 4)	NC score	0.891985 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	58	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP1B1_HUMAN
θ value	1.95861e-79 (rank : 5)	NC score	0.890886 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	58	Shared Neighborhood Hits	26
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_MOUSE
θ value	3.34088e-79 (rank : 6)	NC score	0.889868 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	26
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP3B2_HUMAN
θ value	1.85029e-45 (rank : 7)	NC score	0.790862 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	246	Shared Neighborhood Hits	17
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP3B2_MOUSE
θ value	1.85029e-45 (rank : 8)	NC score	0.789006 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	246	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

AP3B1_MOUSE
θ value	4.71619e-41 (rank : 9)	NC score	0.787877 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	302	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B1_HUMAN
θ value	1.51715e-39 (rank : 10)	NC score	0.786123 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	283	Shared Neighborhood Hits	20
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

COPG2_MOUSE
θ value	2.69671e-12 (rank : 11)	NC score	0.444515 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	32	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG2_HUMAN
θ value	1.02475e-11 (rank : 12)	NC score	0.438817 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	33	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

AP1G2_MOUSE
θ value	9.59137e-10 (rank : 13)	NC score	0.371400 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	52	Shared Neighborhood Hits	24
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

COPG_HUMAN
θ value	4.76016e-09 (rank : 14)	NC score	0.392772 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

AP1G2_HUMAN
θ value	3.77169e-06 (rank : 15)	NC score	0.316887 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	44	Shared Neighborhood Hits	23
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP3D1_HUMAN
θ value	0.000158464 (rank : 16)	NC score	0.381548 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	254	Shared Neighborhood Hits	26
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

AP3D1_MOUSE
θ value	0.00020696 (rank : 17)	NC score	0.396952 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	144	Shared Neighborhood Hits	25
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP1G1_HUMAN
θ value	0.000270298 (rank : 18)	NC score	0.350174 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	65	Shared Neighborhood Hits	25
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_MOUSE
θ value	0.000270298 (rank : 19)	NC score	0.350563 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

COPB_HUMAN
θ value	0.00390308 (rank : 20)	NC score	0.426307 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	47	Shared Neighborhood Hits	21
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_MOUSE
θ value	0.00390308 (rank : 21)	NC score	0.425996 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	50	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

AP2A2_MOUSE
θ value	0.0113563 (rank : 22)	NC score	0.287544 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	46	Shared Neighborhood Hits	16
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP2A2_HUMAN
θ value	0.0193708 (rank : 23)	NC score	0.286979 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	39	Shared Neighborhood Hits	16
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

PK3CA_HUMAN
θ value	1.06291 (rank : 24)	NC score	0.023607 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

AP2A1_HUMAN
θ value	3.0926 (rank : 25)	NC score	0.253155 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_MOUSE
θ value	3.0926 (rank : 26)	NC score	0.250690 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

RPB9_HUMAN
θ value	4.03905 (rank : 27)	NC score	0.027975 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	P36954, Q6NW05	Gene names	POLR2I
Domain Architecture
Description	DNA-directed RNA polymerase II subunit I (EC 2.7.7.6) (DNA-directed RNA polymerase II 14.5 kDa polypeptide) (RPB9) (RPB14.5).

RPB9_MOUSE
θ value	4.03905 (rank : 28)	NC score	0.027975 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	P60898	Gene names	Polr2i
Domain Architecture
Description	DNA-directed RNA polymerase II subunit I (EC 2.7.7.6) (DNA-directed RNA polymerase II 14.5 kDa polypeptide) (RPB9) (RPB14.5).

TRIPC_HUMAN
θ value	4.03905 (rank : 29)	NC score	0.009444 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	319	Shared Neighborhood Hits	3
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

DJBP_HUMAN
θ value	5.27518 (rank : 30)	NC score	0.011643 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	156	Shared Neighborhood Hits	2
SwissProt Accessions	Q5THR3, Q5U5T6, Q9BY88, Q9H5C4, Q9NSF5	Gene names	DJBP, KIAA1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein (CAP-binding protein complex-interacting protein 1).

DRP2_HUMAN
θ value	5.27518 (rank : 31)	NC score	0.011768 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	186	Shared Neighborhood Hits	3
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

MERTK_MOUSE
θ value	5.27518 (rank : 32)	NC score	-0.001339 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	974	Shared Neighborhood Hits	2
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

PK3CA_MOUSE
θ value	5.27518 (rank : 33)	NC score	0.021151 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PLAK_MOUSE
θ value	5.27518 (rank : 34)	NC score	0.018262 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q02257, Q8CGD3	Gene names	Jup
Domain Architecture	No domain graphic available
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

FXL20_HUMAN
θ value	6.88961 (rank : 35)	NC score	0.016407 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	77	Shared Neighborhood Hits	4
SwissProt Accessions	Q96IG2	Gene names	FBXL20, FBL2
Domain Architecture
Description	F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like).

FXL20_MOUSE
θ value	6.88961 (rank : 36)	NC score	0.016437 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CZV8, Q8BZ95	Gene names	Fbxl20, Fbl2
Domain Architecture
Description	F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like).

IP3KB_HUMAN
θ value	6.88961 (rank : 37)	NC score	0.013534 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	124	Shared Neighborhood Hits	3
SwissProt Accessions	P27987, Q5VWL9, Q5VWM0, Q96BZ2, Q96JS1, Q9UH47	Gene names	ITPKB
Domain Architecture
Description	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase B) (IP3K B) (IP3 3-kinase B) (IP3K-B).

PLAK_HUMAN
θ value	6.88961 (rank : 38)	NC score	0.016997 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	53	Shared Neighborhood Hits	4
SwissProt Accessions	P14923, Q9HCX9	Gene names	JUP, DP3
Domain Architecture
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

RNBP6_HUMAN
θ value	6.88961 (rank : 39)	NC score	0.011536 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	O60518, Q5T7X4, Q7Z3V2, Q96E78	Gene names	RANBP6
Domain Architecture	No domain graphic available
Description	Ran-binding protein 6 (RanBP6).

CN135_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.012823 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q63HM2, Q9BQG8, Q9H9F2	Gene names	C14orf135, FBP2
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf135 precursor (Hepatitis C virus F protein-binding protein 2) (HCV F protein-binding protein 2).

TAF5L_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.002375 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	330	Shared Neighborhood Hits	3
SwissProt Accessions	O75529, Q8IW31	Gene names	TAF5L, PAF65B
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

AP4E1_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.256861 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	57	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP4E1_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.254318 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	23
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

SPAG6_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.050945 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

Hits sorted by NC score

AP4B1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_HUMAN
NC score	0.995354 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP2B1_MOUSE
NC score	0.891985 (rank : 3)	θ value	5.15425e-80 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	58	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_HUMAN
NC score	0.891964 (rank : 4)	θ value	5.15425e-80 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	27
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP1B1_HUMAN
NC score	0.890886 (rank : 5)	θ value	1.95861e-79 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	58	Shared Neighborhood Hits	26
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_MOUSE
NC score	0.889868 (rank : 6)	θ value	3.34088e-79 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	26
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP3B2_HUMAN
NC score	0.790862 (rank : 7)	θ value	1.85029e-45 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	246	Shared Neighborhood Hits	17
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP3B2_MOUSE
NC score	0.789006 (rank : 8)	θ value	1.85029e-45 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	246	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

AP3B1_MOUSE
NC score	0.787877 (rank : 9)	θ value	4.71619e-41 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	302	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B1_HUMAN
NC score	0.786123 (rank : 10)	θ value	1.51715e-39 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	283	Shared Neighborhood Hits	20
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

COPG2_MOUSE
NC score	0.444515 (rank : 11)	θ value	2.69671e-12 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	32	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG2_HUMAN
NC score	0.438817 (rank : 12)	θ value	1.02475e-11 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	33	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPB_HUMAN
NC score	0.426307 (rank : 13)	θ value	0.00390308 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	47	Shared Neighborhood Hits	21
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_MOUSE
NC score	0.425996 (rank : 14)	θ value	0.00390308 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	50	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

AP3D1_MOUSE
NC score	0.396952 (rank : 15)	θ value	0.00020696 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	144	Shared Neighborhood Hits	25
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

COPG_HUMAN
NC score	0.392772 (rank : 16)	θ value	4.76016e-09 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

AP3D1_HUMAN
NC score	0.381548 (rank : 17)	θ value	0.000158464 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	254	Shared Neighborhood Hits	26
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

AP1G2_MOUSE
NC score	0.371400 (rank : 18)	θ value	9.59137e-10 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	52	Shared Neighborhood Hits	24
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP1G1_MOUSE
NC score	0.350563 (rank : 19)	θ value	0.000270298 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_HUMAN
NC score	0.350174 (rank : 20)	θ value	0.000270298 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	65	Shared Neighborhood Hits	25
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G2_HUMAN
NC score	0.316887 (rank : 21)	θ value	3.77169e-06 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	44	Shared Neighborhood Hits	23
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP2A2_MOUSE
NC score	0.287544 (rank : 22)	θ value	0.0113563 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	46	Shared Neighborhood Hits	16
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP2A2_HUMAN
NC score	0.286979 (rank : 23)	θ value	0.0193708 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	39	Shared Neighborhood Hits	16
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP4E1_HUMAN
NC score	0.256861 (rank : 24)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	57	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP4E1_MOUSE
NC score	0.254318 (rank : 25)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	23
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP2A1_HUMAN
NC score	0.253155 (rank : 26)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_MOUSE
NC score	0.250690 (rank : 27)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

SPAG6_HUMAN
NC score	0.050945 (rank : 28)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

RPB9_HUMAN
NC score	0.027975 (rank : 29)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	P36954, Q6NW05	Gene names	POLR2I
Domain Architecture
Description	DNA-directed RNA polymerase II subunit I (EC 2.7.7.6) (DNA-directed RNA polymerase II 14.5 kDa polypeptide) (RPB9) (RPB14.5).

RPB9_MOUSE
NC score	0.027975 (rank : 30)	θ value	4.03905 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	P60898	Gene names	Polr2i
Domain Architecture
Description	DNA-directed RNA polymerase II subunit I (EC 2.7.7.6) (DNA-directed RNA polymerase II 14.5 kDa polypeptide) (RPB9) (RPB14.5).

PK3CA_HUMAN
NC score	0.023607 (rank : 31)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
NC score	0.021151 (rank : 32)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PLAK_MOUSE
NC score	0.018262 (rank : 33)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q02257, Q8CGD3	Gene names	Jup
Domain Architecture	No domain graphic available
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

PLAK_HUMAN
NC score	0.016997 (rank : 34)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	53	Shared Neighborhood Hits	4
SwissProt Accessions	P14923, Q9HCX9	Gene names	JUP, DP3
Domain Architecture
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

FXL20_MOUSE
NC score	0.016437 (rank : 35)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CZV8, Q8BZ95	Gene names	Fbxl20, Fbl2
Domain Architecture
Description	F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like).

FXL20_HUMAN
NC score	0.016407 (rank : 36)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	77	Shared Neighborhood Hits	4
SwissProt Accessions	Q96IG2	Gene names	FBXL20, FBL2
Domain Architecture
Description	F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like).

IP3KB_HUMAN
NC score	0.013534 (rank : 37)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	124	Shared Neighborhood Hits	3
SwissProt Accessions	P27987, Q5VWL9, Q5VWM0, Q96BZ2, Q96JS1, Q9UH47	Gene names	ITPKB
Domain Architecture
Description	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase B) (IP3K B) (IP3 3-kinase B) (IP3K-B).

CN135_HUMAN
NC score	0.012823 (rank : 38)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q63HM2, Q9BQG8, Q9H9F2	Gene names	C14orf135, FBP2
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf135 precursor (Hepatitis C virus F protein-binding protein 2) (HCV F protein-binding protein 2).

DRP2_HUMAN
NC score	0.011768 (rank : 39)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	186	Shared Neighborhood Hits	3
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

DJBP_HUMAN
NC score	0.011643 (rank : 40)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	156	Shared Neighborhood Hits	2
SwissProt Accessions	Q5THR3, Q5U5T6, Q9BY88, Q9H5C4, Q9NSF5	Gene names	DJBP, KIAA1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein (CAP-binding protein complex-interacting protein 1).

RNBP6_HUMAN
NC score	0.011536 (rank : 41)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	O60518, Q5T7X4, Q7Z3V2, Q96E78	Gene names	RANBP6
Domain Architecture	No domain graphic available
Description	Ran-binding protein 6 (RanBP6).

TRIPC_HUMAN
NC score	0.009444 (rank : 42)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	319	Shared Neighborhood Hits	3
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

TAF5L_HUMAN
NC score	0.002375 (rank : 43)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	330	Shared Neighborhood Hits	3
SwissProt Accessions	O75529, Q8IW31	Gene names	TAF5L, PAF65B
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

MERTK_MOUSE
NC score	-0.001339 (rank : 44)	θ value	5.27518 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	974	Shared Neighborhood Hits	2
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).