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Network neighborhood for query Sequence : COPG_HUMAN

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COPG_HUMAN
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

COPG2_HUMAN
θ value	0 (rank : 1)	NC score	0.993604 (rank : 2)
Query Neighborhood Hits	31	Target Neighborhood Hits	33	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG2_MOUSE
θ value	0 (rank : 2)	NC score	0.993190 (rank : 3)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	31	Target Neighborhood Hits	31	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

AP1B1_HUMAN
θ value	1.9326e-10 (rank : 4)	NC score	0.374301 (rank : 5)
Query Neighborhood Hits	31	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_MOUSE
θ value	2.52405e-10 (rank : 5)	NC score	0.373406 (rank : 6)
Query Neighborhood Hits	31	Target Neighborhood Hits	59	Shared Neighborhood Hits	19
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP2B1_HUMAN
θ value	1.25267e-09 (rank : 6)	NC score	0.370401 (rank : 8)
Query Neighborhood Hits	31	Target Neighborhood Hits	59	Shared Neighborhood Hits	19
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_MOUSE
θ value	1.25267e-09 (rank : 7)	NC score	0.370410 (rank : 7)
Query Neighborhood Hits	31	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP4B1_MOUSE
θ value	4.76016e-09 (rank : 8)	NC score	0.392772 (rank : 4)
Query Neighborhood Hits	31	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP1G1_HUMAN
θ value	1.87187e-05 (rank : 9)	NC score	0.229404 (rank : 11)
Query Neighborhood Hits	31	Target Neighborhood Hits	65	Shared Neighborhood Hits	19
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_MOUSE
θ value	1.87187e-05 (rank : 10)	NC score	0.230007 (rank : 10)
Query Neighborhood Hits	31	Target Neighborhood Hits	67	Shared Neighborhood Hits	19
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP4B1_HUMAN
θ value	0.00102713 (rank : 11)	NC score	0.336641 (rank : 9)
Query Neighborhood Hits	31	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP3D1_MOUSE
θ value	0.0431538 (rank : 12)	NC score	0.204785 (rank : 12)
Query Neighborhood Hits	31	Target Neighborhood Hits	144	Shared Neighborhood Hits	18
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP4E1_HUMAN
θ value	0.21417 (rank : 13)	NC score	0.162392 (rank : 18)
Query Neighborhood Hits	31	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

TIM44_HUMAN
θ value	0.365318 (rank : 14)	NC score	0.040660 (rank : 28)
Query Neighborhood Hits	31	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	O43615, Q8N193	Gene names	TIMM44, MIMT44, TIM44
Domain Architecture
Description	Import inner membrane translocase subunit TIM44, mitochondrial precursor.

AP3D1_HUMAN
θ value	0.47712 (rank : 15)	NC score	0.195495 (rank : 14)
Query Neighborhood Hits	31	Target Neighborhood Hits	254	Shared Neighborhood Hits	18
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

AP4E1_MOUSE
θ value	1.06291 (rank : 16)	NC score	0.162367 (rank : 19)
Query Neighborhood Hits	31	Target Neighborhood Hits	59	Shared Neighborhood Hits	16
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

BRE1B_HUMAN
θ value	1.38821 (rank : 17)	NC score	0.011988 (rank : 35)
Query Neighborhood Hits	31	Target Neighborhood Hits	1040	Shared Neighborhood Hits	4
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

CDC23_HUMAN
θ value	1.38821 (rank : 18)	NC score	0.025403 (rank : 32)
Query Neighborhood Hits	31	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UJX2, O75433, Q9BS73	Gene names	CDC23
Domain Architecture
Description	Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8).

COPB_HUMAN
θ value	1.38821 (rank : 19)	NC score	0.186829 (rank : 16)
Query Neighborhood Hits	31	Target Neighborhood Hits	47	Shared Neighborhood Hits	18
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_MOUSE
θ value	1.38821 (rank : 20)	NC score	0.185432 (rank : 17)
Query Neighborhood Hits	31	Target Neighborhood Hits	50	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

ABC8B_MOUSE
θ value	3.0926 (rank : 21)	NC score	0.007083 (rank : 40)
Query Neighborhood Hits	31	Target Neighborhood Hits	124	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K440, Q69ZY4, Q8BRQ1, Q9JL38	Gene names	Abca8b, Abca8, Kiaa0822
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 8-B.

AP1G2_HUMAN
θ value	3.0926 (rank : 22)	NC score	0.152081 (rank : 21)
Query Neighborhood Hits	31	Target Neighborhood Hits	44	Shared Neighborhood Hits	18
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

CAND2_HUMAN
θ value	3.0926 (rank : 23)	NC score	0.033298 (rank : 30)
Query Neighborhood Hits	31	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	O75155	Gene names	CAND2, KIAA0667
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2).

CAND2_MOUSE
θ value	3.0926 (rank : 24)	NC score	0.032485 (rank : 31)
Query Neighborhood Hits	31	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZQ73, Q6PHT7	Gene names	Cand2, Kiaa0667, Tip120b
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2) (TBP-interacting protein TIP120B) (TBP-interacting protein of 120 kDa B).

K0056_MOUSE
θ value	3.0926 (rank : 25)	NC score	0.036166 (rank : 29)
Query Neighborhood Hits	31	Target Neighborhood Hits	67	Shared Neighborhood Hits	8
SwissProt Accessions	Q6ZQK0, Q9CS21	Gene names	Kiaa0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

UB2V1_HUMAN
θ value	4.03905 (rank : 26)	NC score	0.016059 (rank : 34)
Query Neighborhood Hits	31	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	Q13404, Q13403, Q13532, Q96H34, Q9GZT0, Q9GZW1, Q9H4J3, Q9H4J4, Q9UKL1, Q9UM48, Q9UM49, Q9UM50	Gene names	UBE2V1, CROC1, UBE2V, UEV1
Domain Architecture	No domain graphic available
Description	Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (Ubiquitin- conjugating enzyme variant Kua) (TRAF6-regulated IKK activator 1 beta Uev1A).

TARSH_HUMAN
θ value	5.27518 (rank : 27)	NC score	0.010045 (rank : 37)
Query Neighborhood Hits	31	Target Neighborhood Hits	768	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

BRE1B_MOUSE
θ value	6.88961 (rank : 28)	NC score	0.009585 (rank : 38)
Query Neighborhood Hits	31	Target Neighborhood Hits	970	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

CASPA_HUMAN
θ value	8.99809 (rank : 29)	NC score	0.018074 (rank : 33)
Query Neighborhood Hits	31	Target Neighborhood Hits	53	Shared Neighborhood Hits	4
SwissProt Accessions	Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7	Gene names	CASP10, MCH4
Domain Architecture
Description	Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].

COA1_HUMAN
θ value	8.99809 (rank : 30)	NC score	0.007703 (rank : 39)
Query Neighborhood Hits	31	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

RIB1_HUMAN
θ value	8.99809 (rank : 31)	NC score	0.011152 (rank : 36)
Query Neighborhood Hits	31	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	P04843	Gene names	RPN1
Domain Architecture
Description	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit precursor (EC 2.4.1.119) (Ribophorin I) (RPN-I).

AP1G2_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.148426 (rank : 23)
Query Neighborhood Hits	31	Target Neighborhood Hits	52	Shared Neighborhood Hits	17
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP2A1_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.111688 (rank : 26)
Query Neighborhood Hits	31	Target Neighborhood Hits	56	Shared Neighborhood Hits	13
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_MOUSE
θ value	θ > 10 (rank : 34)	NC score	0.109712 (rank : 27)
Query Neighborhood Hits	31	Target Neighborhood Hits	57	Shared Neighborhood Hits	13
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A2_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.119029 (rank : 24)
Query Neighborhood Hits	31	Target Neighborhood Hits	39	Shared Neighborhood Hits	14
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP2A2_MOUSE
θ value	θ > 10 (rank : 36)	NC score	0.118720 (rank : 25)
Query Neighborhood Hits	31	Target Neighborhood Hits	46	Shared Neighborhood Hits	14
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP3B1_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.191321 (rank : 15)
Query Neighborhood Hits	31	Target Neighborhood Hits	283	Shared Neighborhood Hits	18
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B1_MOUSE
θ value	θ > 10 (rank : 38)	NC score	0.198468 (rank : 13)
Query Neighborhood Hits	31	Target Neighborhood Hits	302	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B2_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.151636 (rank : 22)
Query Neighborhood Hits	31	Target Neighborhood Hits	246	Shared Neighborhood Hits	14
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP3B2_MOUSE
θ value	θ > 10 (rank : 40)	NC score	0.152541 (rank : 20)
Query Neighborhood Hits	31	Target Neighborhood Hits	246	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

Hits sorted by NC score

COPG_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	31	Target Neighborhood Hits	31	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

COPG2_HUMAN
NC score	0.993604 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	31	Target Neighborhood Hits	33	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG2_MOUSE
NC score	0.993190 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

AP4B1_MOUSE
NC score	0.392772 (rank : 4)	θ value	4.76016e-09 (rank : 8)
Query Neighborhood Hits	31	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP1B1_HUMAN
NC score	0.374301 (rank : 5)	θ value	1.9326e-10 (rank : 4)
Query Neighborhood Hits	31	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_MOUSE
NC score	0.373406 (rank : 6)	θ value	2.52405e-10 (rank : 5)
Query Neighborhood Hits	31	Target Neighborhood Hits	59	Shared Neighborhood Hits	19
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP2B1_MOUSE
NC score	0.370410 (rank : 7)	θ value	1.25267e-09 (rank : 7)
Query Neighborhood Hits	31	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_HUMAN
NC score	0.370401 (rank : 8)	θ value	1.25267e-09 (rank : 6)
Query Neighborhood Hits	31	Target Neighborhood Hits	59	Shared Neighborhood Hits	19
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP4B1_HUMAN
NC score	0.336641 (rank : 9)	θ value	0.00102713 (rank : 11)
Query Neighborhood Hits	31	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP1G1_MOUSE
NC score	0.230007 (rank : 10)	θ value	1.87187e-05 (rank : 10)
Query Neighborhood Hits	31	Target Neighborhood Hits	67	Shared Neighborhood Hits	19
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_HUMAN
NC score	0.229404 (rank : 11)	θ value	1.87187e-05 (rank : 9)
Query Neighborhood Hits	31	Target Neighborhood Hits	65	Shared Neighborhood Hits	19
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP3D1_MOUSE
NC score	0.204785 (rank : 12)	θ value	0.0431538 (rank : 12)
Query Neighborhood Hits	31	Target Neighborhood Hits	144	Shared Neighborhood Hits	18
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP3B1_MOUSE
NC score	0.198468 (rank : 13)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	31	Target Neighborhood Hits	302	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3D1_HUMAN
NC score	0.195495 (rank : 14)	θ value	0.47712 (rank : 15)
Query Neighborhood Hits	31	Target Neighborhood Hits	254	Shared Neighborhood Hits	18
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

AP3B1_HUMAN
NC score	0.191321 (rank : 15)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	31	Target Neighborhood Hits	283	Shared Neighborhood Hits	18
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

COPB_HUMAN
NC score	0.186829 (rank : 16)	θ value	1.38821 (rank : 19)
Query Neighborhood Hits	31	Target Neighborhood Hits	47	Shared Neighborhood Hits	18
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_MOUSE
NC score	0.185432 (rank : 17)	θ value	1.38821 (rank : 20)
Query Neighborhood Hits	31	Target Neighborhood Hits	50	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

AP4E1_HUMAN
NC score	0.162392 (rank : 18)	θ value	0.21417 (rank : 13)
Query Neighborhood Hits	31	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP4E1_MOUSE
NC score	0.162367 (rank : 19)	θ value	1.06291 (rank : 16)
Query Neighborhood Hits	31	Target Neighborhood Hits	59	Shared Neighborhood Hits	16
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP3B2_MOUSE
NC score	0.152541 (rank : 20)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	31	Target Neighborhood Hits	246	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

AP1G2_HUMAN
NC score	0.152081 (rank : 21)	θ value	3.0926 (rank : 22)
Query Neighborhood Hits	31	Target Neighborhood Hits	44	Shared Neighborhood Hits	18
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP3B2_HUMAN
NC score	0.151636 (rank : 22)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	31	Target Neighborhood Hits	246	Shared Neighborhood Hits	14
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP1G2_MOUSE
NC score	0.148426 (rank : 23)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	31	Target Neighborhood Hits	52	Shared Neighborhood Hits	17
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP2A2_HUMAN
NC score	0.119029 (rank : 24)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	31	Target Neighborhood Hits	39	Shared Neighborhood Hits	14
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP2A2_MOUSE
NC score	0.118720 (rank : 25)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	31	Target Neighborhood Hits	46	Shared Neighborhood Hits	14
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP2A1_HUMAN
NC score	0.111688 (rank : 26)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	31	Target Neighborhood Hits	56	Shared Neighborhood Hits	13
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_MOUSE
NC score	0.109712 (rank : 27)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	31	Target Neighborhood Hits	57	Shared Neighborhood Hits	13
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

TIM44_HUMAN
NC score	0.040660 (rank : 28)	θ value	0.365318 (rank : 14)
Query Neighborhood Hits	31	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	O43615, Q8N193	Gene names	TIMM44, MIMT44, TIM44
Domain Architecture
Description	Import inner membrane translocase subunit TIM44, mitochondrial precursor.

K0056_MOUSE
NC score	0.036166 (rank : 29)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	31	Target Neighborhood Hits	67	Shared Neighborhood Hits	8
SwissProt Accessions	Q6ZQK0, Q9CS21	Gene names	Kiaa0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

CAND2_HUMAN
NC score	0.033298 (rank : 30)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	31	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	O75155	Gene names	CAND2, KIAA0667
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2).

CAND2_MOUSE
NC score	0.032485 (rank : 31)	θ value	3.0926 (rank : 24)
Query Neighborhood Hits	31	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZQ73, Q6PHT7	Gene names	Cand2, Kiaa0667, Tip120b
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2) (TBP-interacting protein TIP120B) (TBP-interacting protein of 120 kDa B).

CDC23_HUMAN
NC score	0.025403 (rank : 32)	θ value	1.38821 (rank : 18)
Query Neighborhood Hits	31	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UJX2, O75433, Q9BS73	Gene names	CDC23
Domain Architecture
Description	Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8).

CASPA_HUMAN
NC score	0.018074 (rank : 33)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	31	Target Neighborhood Hits	53	Shared Neighborhood Hits	4
SwissProt Accessions	Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7	Gene names	CASP10, MCH4
Domain Architecture
Description	Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].

UB2V1_HUMAN
NC score	0.016059 (rank : 34)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	31	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	Q13404, Q13403, Q13532, Q96H34, Q9GZT0, Q9GZW1, Q9H4J3, Q9H4J4, Q9UKL1, Q9UM48, Q9UM49, Q9UM50	Gene names	UBE2V1, CROC1, UBE2V, UEV1
Domain Architecture	No domain graphic available
Description	Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (Ubiquitin- conjugating enzyme variant Kua) (TRAF6-regulated IKK activator 1 beta Uev1A).

BRE1B_HUMAN
NC score	0.011988 (rank : 35)	θ value	1.38821 (rank : 17)
Query Neighborhood Hits	31	Target Neighborhood Hits	1040	Shared Neighborhood Hits	4
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

RIB1_HUMAN
NC score	0.011152 (rank : 36)	θ value	8.99809 (rank : 31)
Query Neighborhood Hits	31	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	P04843	Gene names	RPN1
Domain Architecture
Description	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit precursor (EC 2.4.1.119) (Ribophorin I) (RPN-I).

TARSH_HUMAN
NC score	0.010045 (rank : 37)	θ value	5.27518 (rank : 27)
Query Neighborhood Hits	31	Target Neighborhood Hits	768	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

BRE1B_MOUSE
NC score	0.009585 (rank : 38)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	31	Target Neighborhood Hits	970	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

COA1_HUMAN
NC score	0.007703 (rank : 39)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	31	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

ABC8B_MOUSE
NC score	0.007083 (rank : 40)	θ value	3.0926 (rank : 21)
Query Neighborhood Hits	31	Target Neighborhood Hits	124	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K440, Q69ZY4, Q8BRQ1, Q9JL38	Gene names	Abca8b, Abca8, Kiaa0822
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 8-B.