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Network neighborhood for query Sequence : CASPA_HUMAN

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CASPA_HUMAN
SwissProt Accessions	Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7	Gene names	CASP10, MCH4
Domain Architecture
Description	Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CASPA_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	53	Target Neighborhood Hits	53	Shared Neighborhood Hits	53
SwissProt Accessions	Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7	Gene names	CASP10, MCH4
Domain Architecture
Description	Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].

CASP8_HUMAN
θ value	9.76566e-63 (rank : 2)	NC score	0.943414 (rank : 3)
Query Neighborhood Hits	53	Target Neighborhood Hits	62	Shared Neighborhood Hits	28
SwissProt Accessions	Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81	Gene names	CASP8, MCH5
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CASP8_MOUSE
θ value	5.35859e-61 (rank : 3)	NC score	0.946179 (rank : 2)
Query Neighborhood Hits	53	Target Neighborhood Hits	57	Shared Neighborhood Hits	26
SwissProt Accessions	O89110, O35669	Gene names	Casp8
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CASP7_MOUSE
θ value	5.39604e-37 (rank : 4)	NC score	0.908356 (rank : 4)
Query Neighborhood Hits	53	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	P97864, O08669	Gene names	Casp7, Lice2, Mch3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP7_HUMAN
θ value	2.67802e-36 (rank : 5)	NC score	0.905382 (rank : 5)
Query Neighborhood Hits	53	Target Neighborhood Hits	26	Shared Neighborhood Hits	22
SwissProt Accessions	P55210, Q13364, Q96BA0	Gene names	CASP7, MCH3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP3_MOUSE
θ value	4.14116e-29 (rank : 6)	NC score	0.897133 (rank : 6)
Query Neighborhood Hits	53	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	P70677, O08668, Q8CHV5, Q9QWI4	Gene names	Casp3, Cpp32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP3_HUMAN
θ value	1.73987e-27 (rank : 7)	NC score	0.895910 (rank : 7)
Query Neighborhood Hits	53	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	P42574, Q96AN1, Q96KP2	Gene names	CASP3, CPP32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP2_MOUSE
θ value	8.63488e-27 (rank : 8)	NC score	0.854187 (rank : 12)
Query Neighborhood Hits	53	Target Neighborhood Hits	34	Shared Neighborhood Hits	22
SwissProt Accessions	P29594, O08737, Q3TCM0, Q8C9H7, Q8K241	Gene names	Casp2, Ich1, Nedd-2, Nedd2
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP2_HUMAN
θ value	1.62847e-25 (rank : 9)	NC score	0.854297 (rank : 11)
Query Neighborhood Hits	53	Target Neighborhood Hits	31	Shared Neighborhood Hits	22
SwissProt Accessions	P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9	Gene names	CASP2, ICH1
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP6_HUMAN
θ value	2.12685e-25 (rank : 10)	NC score	0.880837 (rank : 9)
Query Neighborhood Hits	53	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	P55212, Q9BQE7	Gene names	CASP6, MCH2
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP6_MOUSE
θ value	8.08199e-25 (rank : 11)	NC score	0.879405 (rank : 10)
Query Neighborhood Hits	53	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	O08738	Gene names	Casp6
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP9_HUMAN
θ value	1.16704e-23 (rank : 12)	NC score	0.882521 (rank : 8)
Query Neighborhood Hits	53	Target Neighborhood Hits	33	Shared Neighborhood Hits	22
SwissProt Accessions	P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8	Gene names	CASP9, MCH6
Domain Architecture
Description	Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].

CFLAR_HUMAN
θ value	1.99067e-23 (rank : 13)	NC score	0.752506 (rank : 15)
Query Neighborhood Hits	53	Target Neighborhood Hits	47	Shared Neighborhood Hits	24
SwissProt Accessions	O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1	Gene names	CFLAR, CASH, CLARP, MRIT
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

CASP1_MOUSE
θ value	7.32683e-18 (rank : 14)	NC score	0.707534 (rank : 16)
Query Neighborhood Hits	53	Target Neighborhood Hits	38	Shared Neighborhood Hits	22
SwissProt Accessions	P29452	Gene names	Casp1, Il1bc
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CASPE_HUMAN
θ value	1.38178e-16 (rank : 15)	NC score	0.818249 (rank : 13)
Query Neighborhood Hits	53	Target Neighborhood Hits	26	Shared Neighborhood Hits	21
SwissProt Accessions	P31944, O95823, Q3SYC9	Gene names	CASP14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

CFLAR_MOUSE
θ value	1.16975e-15 (rank : 16)	NC score	0.706891 (rank : 17)
Query Neighborhood Hits	53	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	O35732, O35707, O35733	Gene names	Cflar, Cash
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

CASP1_HUMAN
θ value	4.91457e-14 (rank : 17)	NC score	0.688689 (rank : 18)
Query Neighborhood Hits	53	Target Neighborhood Hits	41	Shared Neighborhood Hits	22
SwissProt Accessions	P29466, Q9UCN3	Gene names	CASP1, IL1BC, IL1BCE
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CASP5_HUMAN
θ value	1.09485e-13 (rank : 18)	NC score	0.684824 (rank : 19)
Query Neighborhood Hits	53	Target Neighborhood Hits	28	Shared Neighborhood Hits	21
SwissProt Accessions	P51878	Gene names	CASP5, ICH3
Domain Architecture
Description	Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].

CASPE_MOUSE
θ value	1.86753e-13 (rank : 19)	NC score	0.813933 (rank : 14)
Query Neighborhood Hits	53	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	O89094	Gene names	Casp14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

CASP4_HUMAN
θ value	4.30538e-10 (rank : 20)	NC score	0.655603 (rank : 21)
Query Neighborhood Hits	53	Target Neighborhood Hits	23	Shared Neighborhood Hits	21
SwissProt Accessions	P49662	Gene names	CASP4, ICH2
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].

CASP4_MOUSE
θ value	4.0297e-08 (rank : 21)	NC score	0.678461 (rank : 20)
Query Neighborhood Hits	53	Target Neighborhood Hits	28	Shared Neighborhood Hits	22
SwissProt Accessions	P70343, O08735	Gene names	Casp4, Casp11, Caspl, Ich3
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].

CASPC_MOUSE
θ value	4.0297e-08 (rank : 22)	NC score	0.651440 (rank : 22)
Query Neighborhood Hits	53	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	O08736, Q3TT82	Gene names	Casp12
Domain Architecture
Description	Caspase-12 precursor (EC 3.4.22.-) (CASP-12).

FADD_HUMAN
θ value	9.29e-05 (rank : 23)	NC score	0.274936 (rank : 23)
Query Neighborhood Hits	53	Target Neighborhood Hits	20	Shared Neighborhood Hits	7
SwissProt Accessions	Q13158, Q14866	Gene names	FADD, MORT1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

FADD_MOUSE
θ value	0.00102713 (rank : 24)	NC score	0.246117 (rank : 24)
Query Neighborhood Hits	53	Target Neighborhood Hits	23	Shared Neighborhood Hits	9
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

PEA15_HUMAN
θ value	0.0961366 (rank : 25)	NC score	0.163259 (rank : 26)
Query Neighborhood Hits	53	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q15121, O00511	Gene names	PEA15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes) (PED).

PEA15_MOUSE
θ value	0.0961366 (rank : 26)	NC score	0.164036 (rank : 25)
Query Neighborhood Hits	53	Target Neighborhood Hits	7	Shared Neighborhood Hits	6
SwissProt Accessions	Q62048, Q3U5N7	Gene names	Pea15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15.

GCC2_HUMAN
θ value	0.279714 (rank : 27)	NC score	0.015917 (rank : 39)
Query Neighborhood Hits	53	Target Neighborhood Hits	1558	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

NBN_MOUSE
θ value	0.279714 (rank : 28)	NC score	0.037218 (rank : 29)
Query Neighborhood Hits	53	Target Neighborhood Hits	125	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R207, O88981, Q3UY57, Q811I6, Q8CCY0, Q9R1X1	Gene names	Nbn, Nbs1
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1 homolog) (Cell cycle regulatory protein p95).

RBP24_HUMAN
θ value	0.279714 (rank : 29)	NC score	0.015975 (rank : 38)
Query Neighborhood Hits	53	Target Neighborhood Hits	1559	Shared Neighborhood Hits	10
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

CP135_MOUSE
θ value	0.47712 (rank : 30)	NC score	0.012576 (rank : 42)
Query Neighborhood Hits	53	Target Neighborhood Hits	1278	Shared Neighborhood Hits	10
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CEP55_MOUSE
θ value	0.62314 (rank : 31)	NC score	0.021324 (rank : 31)
Query Neighborhood Hits	53	Target Neighborhood Hits	693	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

HIP1_HUMAN
θ value	1.06291 (rank : 32)	NC score	0.011759 (rank : 46)
Query Neighborhood Hits	53	Target Neighborhood Hits	1016	Shared Neighborhood Hits	9
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

HNRPC_HUMAN
θ value	1.06291 (rank : 33)	NC score	0.020265 (rank : 32)
Query Neighborhood Hits	53	Target Neighborhood Hits	210	Shared Neighborhood Hits	3
SwissProt Accessions	P07910, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3	Gene names	HNRPC
Domain Architecture
Description	Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2).

PDE6B_MOUSE
θ value	1.06291 (rank : 34)	NC score	0.014557 (rank : 40)
Query Neighborhood Hits	53	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

HMMR_HUMAN
θ value	1.81305 (rank : 35)	NC score	0.013658 (rank : 41)
Query Neighborhood Hits	53	Target Neighborhood Hits	1082	Shared Neighborhood Hits	12
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

MED21_HUMAN
θ value	1.81305 (rank : 36)	NC score	0.045842 (rank : 28)
Query Neighborhood Hits	53	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q13503, Q92811	Gene names	SURB7, MED21, SRB7
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 21 (RNA polymerase II holoenzyme component SRB7) (RNAPII complex component SRB7).

PHLB2_MOUSE
θ value	2.36792 (rank : 37)	NC score	0.012218 (rank : 44)
Query Neighborhood Hits	53	Target Neighborhood Hits	1016	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

DEDD2_MOUSE
θ value	4.03905 (rank : 38)	NC score	0.022665 (rank : 30)
Query Neighborhood Hits	53	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q8QZV0, Q569Y9, Q8JZV1	Gene names	Dedd2, Flame3
Domain Architecture	No domain graphic available
Description	DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).

K0179_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.017427 (rank : 37)
Query Neighborhood Hits	53	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q14684, Q8TBZ4	Gene names	KIAA0179
Domain Architecture
Description	Protein KIAA0179.

CDK9_MOUSE
θ value	5.27518 (rank : 40)	NC score	-0.001757 (rank : 53)
Query Neighborhood Hits	53	Target Neighborhood Hits	822	Shared Neighborhood Hits	4
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

COPG2_HUMAN
θ value	5.27518 (rank : 41)	NC score	0.019631 (rank : 33)
Query Neighborhood Hits	53	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

MRCKA_HUMAN
θ value	5.27518 (rank : 42)	NC score	0.001106 (rank : 52)
Query Neighborhood Hits	53	Target Neighborhood Hits	1999	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

NUP98_HUMAN
θ value	5.27518 (rank : 43)	NC score	0.018408 (rank : 34)
Query Neighborhood Hits	53	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P52948, Q8IUT2, Q8WYB0, Q96E54, Q9H3Q4, Q9NT02, Q9UF57, Q9UHX0, Q9Y6J4, Q9Y6J5	Gene names	NUP98
Domain Architecture
Description	Nuclear pore complex protein Nup98-Nup96 precursor [Contains: Nuclear pore complex protein Nup98 (Nucleoporin Nup98) (98 kDa nucleoporin); Nuclear pore complex protein Nup96 (Nucleoporin Nup96) (96 kDa nucleoporin)].

PDE6B_HUMAN
θ value	5.27518 (rank : 44)	NC score	0.011747 (rank : 47)
Query Neighborhood Hits	53	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PTK7_HUMAN
θ value	5.27518 (rank : 45)	NC score	-0.002133 (rank : 54)
Query Neighborhood Hits	53	Target Neighborhood Hits	1103	Shared Neighborhood Hits	4
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

CCD37_MOUSE
θ value	6.88961 (rank : 46)	NC score	0.012389 (rank : 43)
Query Neighborhood Hits	53	Target Neighborhood Hits	199	Shared Neighborhood Hits	5
SwissProt Accessions	Q80VN0, Q6AXD6	Gene names	Ccdc37
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 37.

K0056_HUMAN
θ value	6.88961 (rank : 47)	NC score	0.011828 (rank : 45)
Query Neighborhood Hits	53	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	P42695	Gene names	KIAA0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

RAI1_MOUSE
θ value	6.88961 (rank : 48)	NC score	0.008517 (rank : 49)
Query Neighborhood Hits	53	Target Neighborhood Hits	344	Shared Neighborhood Hits	2
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

URP1_HUMAN
θ value	6.88961 (rank : 49)	NC score	0.008500 (rank : 50)
Query Neighborhood Hits	53	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BQL6, Q8IX34, Q8IYH2, Q9NWM2, Q9NXQ3	Gene names	URP1, C20orf42, KIND1
Domain Architecture
Description	Unc-112-related protein 1 (Kindlin-1) (Kindlerin) (Kindlin syndrome protein).

COPG2_MOUSE
θ value	8.99809 (rank : 50)	NC score	0.017836 (rank : 36)
Query Neighborhood Hits	53	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG_HUMAN
θ value	8.99809 (rank : 51)	NC score	0.018074 (rank : 35)
Query Neighborhood Hits	53	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

DIAP2_HUMAN
θ value	8.99809 (rank : 52)	NC score	0.008765 (rank : 48)
Query Neighborhood Hits	53	Target Neighborhood Hits	342	Shared Neighborhood Hits	7
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

DIAP2_MOUSE
θ value	8.99809 (rank : 53)	NC score	0.007529 (rank : 51)
Query Neighborhood Hits	53	Target Neighborhood Hits	260	Shared Neighborhood Hits	4
SwissProt Accessions	O70566, Q8C2G8	Gene names	Diaph2, Diap2
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) (mDia3).

ICBR_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.140770 (rank : 27)
Query Neighborhood Hits	53	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P57730	Gene names	ICEBERG
Domain Architecture
Description	Caspase-1 inhibitor Iceberg.

Hits sorted by NC score

CASPA_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	53	Target Neighborhood Hits	53	Shared Neighborhood Hits	53
SwissProt Accessions	Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7	Gene names	CASP10, MCH4
Domain Architecture
Description	Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].

CASP8_MOUSE
NC score	0.946179 (rank : 2)	θ value	5.35859e-61 (rank : 3)
Query Neighborhood Hits	53	Target Neighborhood Hits	57	Shared Neighborhood Hits	26
SwissProt Accessions	O89110, O35669	Gene names	Casp8
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CASP8_HUMAN
NC score	0.943414 (rank : 3)	θ value	9.76566e-63 (rank : 2)
Query Neighborhood Hits	53	Target Neighborhood Hits	62	Shared Neighborhood Hits	28
SwissProt Accessions	Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81	Gene names	CASP8, MCH5
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CASP7_MOUSE
NC score	0.908356 (rank : 4)	θ value	5.39604e-37 (rank : 4)
Query Neighborhood Hits	53	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	P97864, O08669	Gene names	Casp7, Lice2, Mch3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP7_HUMAN
NC score	0.905382 (rank : 5)	θ value	2.67802e-36 (rank : 5)
Query Neighborhood Hits	53	Target Neighborhood Hits	26	Shared Neighborhood Hits	22
SwissProt Accessions	P55210, Q13364, Q96BA0	Gene names	CASP7, MCH3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP3_MOUSE
NC score	0.897133 (rank : 6)	θ value	4.14116e-29 (rank : 6)
Query Neighborhood Hits	53	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	P70677, O08668, Q8CHV5, Q9QWI4	Gene names	Casp3, Cpp32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP3_HUMAN
NC score	0.895910 (rank : 7)	θ value	1.73987e-27 (rank : 7)
Query Neighborhood Hits	53	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	P42574, Q96AN1, Q96KP2	Gene names	CASP3, CPP32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP9_HUMAN
NC score	0.882521 (rank : 8)	θ value	1.16704e-23 (rank : 12)
Query Neighborhood Hits	53	Target Neighborhood Hits	33	Shared Neighborhood Hits	22
SwissProt Accessions	P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8	Gene names	CASP9, MCH6
Domain Architecture
Description	Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].

CASP6_HUMAN
NC score	0.880837 (rank : 9)	θ value	2.12685e-25 (rank : 10)
Query Neighborhood Hits	53	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	P55212, Q9BQE7	Gene names	CASP6, MCH2
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP6_MOUSE
NC score	0.879405 (rank : 10)	θ value	8.08199e-25 (rank : 11)
Query Neighborhood Hits	53	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	O08738	Gene names	Casp6
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP2_HUMAN
NC score	0.854297 (rank : 11)	θ value	1.62847e-25 (rank : 9)
Query Neighborhood Hits	53	Target Neighborhood Hits	31	Shared Neighborhood Hits	22
SwissProt Accessions	P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9	Gene names	CASP2, ICH1
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP2_MOUSE
NC score	0.854187 (rank : 12)	θ value	8.63488e-27 (rank : 8)
Query Neighborhood Hits	53	Target Neighborhood Hits	34	Shared Neighborhood Hits	22
SwissProt Accessions	P29594, O08737, Q3TCM0, Q8C9H7, Q8K241	Gene names	Casp2, Ich1, Nedd-2, Nedd2
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASPE_HUMAN
NC score	0.818249 (rank : 13)	θ value	1.38178e-16 (rank : 15)
Query Neighborhood Hits	53	Target Neighborhood Hits	26	Shared Neighborhood Hits	21
SwissProt Accessions	P31944, O95823, Q3SYC9	Gene names	CASP14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

CASPE_MOUSE
NC score	0.813933 (rank : 14)	θ value	1.86753e-13 (rank : 19)
Query Neighborhood Hits	53	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	O89094	Gene names	Casp14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

CFLAR_HUMAN
NC score	0.752506 (rank : 15)	θ value	1.99067e-23 (rank : 13)
Query Neighborhood Hits	53	Target Neighborhood Hits	47	Shared Neighborhood Hits	24
SwissProt Accessions	O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1	Gene names	CFLAR, CASH, CLARP, MRIT
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

CASP1_MOUSE
NC score	0.707534 (rank : 16)	θ value	7.32683e-18 (rank : 14)
Query Neighborhood Hits	53	Target Neighborhood Hits	38	Shared Neighborhood Hits	22
SwissProt Accessions	P29452	Gene names	Casp1, Il1bc
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CFLAR_MOUSE
NC score	0.706891 (rank : 17)	θ value	1.16975e-15 (rank : 16)
Query Neighborhood Hits	53	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	O35732, O35707, O35733	Gene names	Cflar, Cash
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

CASP1_HUMAN
NC score	0.688689 (rank : 18)	θ value	4.91457e-14 (rank : 17)
Query Neighborhood Hits	53	Target Neighborhood Hits	41	Shared Neighborhood Hits	22
SwissProt Accessions	P29466, Q9UCN3	Gene names	CASP1, IL1BC, IL1BCE
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CASP5_HUMAN
NC score	0.684824 (rank : 19)	θ value	1.09485e-13 (rank : 18)
Query Neighborhood Hits	53	Target Neighborhood Hits	28	Shared Neighborhood Hits	21
SwissProt Accessions	P51878	Gene names	CASP5, ICH3
Domain Architecture
Description	Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].

CASP4_MOUSE
NC score	0.678461 (rank : 20)	θ value	4.0297e-08 (rank : 21)
Query Neighborhood Hits	53	Target Neighborhood Hits	28	Shared Neighborhood Hits	22
SwissProt Accessions	P70343, O08735	Gene names	Casp4, Casp11, Caspl, Ich3
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].

CASP4_HUMAN
NC score	0.655603 (rank : 21)	θ value	4.30538e-10 (rank : 20)
Query Neighborhood Hits	53	Target Neighborhood Hits	23	Shared Neighborhood Hits	21
SwissProt Accessions	P49662	Gene names	CASP4, ICH2
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].

CASPC_MOUSE
NC score	0.651440 (rank : 22)	θ value	4.0297e-08 (rank : 22)
Query Neighborhood Hits	53	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	O08736, Q3TT82	Gene names	Casp12
Domain Architecture
Description	Caspase-12 precursor (EC 3.4.22.-) (CASP-12).

FADD_HUMAN
NC score	0.274936 (rank : 23)	θ value	9.29e-05 (rank : 23)
Query Neighborhood Hits	53	Target Neighborhood Hits	20	Shared Neighborhood Hits	7
SwissProt Accessions	Q13158, Q14866	Gene names	FADD, MORT1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

FADD_MOUSE
NC score	0.246117 (rank : 24)	θ value	0.00102713 (rank : 24)
Query Neighborhood Hits	53	Target Neighborhood Hits	23	Shared Neighborhood Hits	9
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

PEA15_MOUSE
NC score	0.164036 (rank : 25)	θ value	0.0961366 (rank : 26)
Query Neighborhood Hits	53	Target Neighborhood Hits	7	Shared Neighborhood Hits	6
SwissProt Accessions	Q62048, Q3U5N7	Gene names	Pea15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15.

PEA15_HUMAN
NC score	0.163259 (rank : 26)	θ value	0.0961366 (rank : 25)
Query Neighborhood Hits	53	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q15121, O00511	Gene names	PEA15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes) (PED).

ICBR_HUMAN
NC score	0.140770 (rank : 27)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	53	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P57730	Gene names	ICEBERG
Domain Architecture
Description	Caspase-1 inhibitor Iceberg.

MED21_HUMAN
NC score	0.045842 (rank : 28)	θ value	1.81305 (rank : 36)
Query Neighborhood Hits	53	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q13503, Q92811	Gene names	SURB7, MED21, SRB7
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 21 (RNA polymerase II holoenzyme component SRB7) (RNAPII complex component SRB7).

NBN_MOUSE
NC score	0.037218 (rank : 29)	θ value	0.279714 (rank : 28)
Query Neighborhood Hits	53	Target Neighborhood Hits	125	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R207, O88981, Q3UY57, Q811I6, Q8CCY0, Q9R1X1	Gene names	Nbn, Nbs1
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1 homolog) (Cell cycle regulatory protein p95).

DEDD2_MOUSE
NC score	0.022665 (rank : 30)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	53	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q8QZV0, Q569Y9, Q8JZV1	Gene names	Dedd2, Flame3
Domain Architecture	No domain graphic available
Description	DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).

CEP55_MOUSE
NC score	0.021324 (rank : 31)	θ value	0.62314 (rank : 31)
Query Neighborhood Hits	53	Target Neighborhood Hits	693	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

HNRPC_HUMAN
NC score	0.020265 (rank : 32)	θ value	1.06291 (rank : 33)
Query Neighborhood Hits	53	Target Neighborhood Hits	210	Shared Neighborhood Hits	3
SwissProt Accessions	P07910, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3	Gene names	HNRPC
Domain Architecture
Description	Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2).

COPG2_HUMAN
NC score	0.019631 (rank : 33)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	53	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

NUP98_HUMAN
NC score	0.018408 (rank : 34)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	53	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P52948, Q8IUT2, Q8WYB0, Q96E54, Q9H3Q4, Q9NT02, Q9UF57, Q9UHX0, Q9Y6J4, Q9Y6J5	Gene names	NUP98
Domain Architecture
Description	Nuclear pore complex protein Nup98-Nup96 precursor [Contains: Nuclear pore complex protein Nup98 (Nucleoporin Nup98) (98 kDa nucleoporin); Nuclear pore complex protein Nup96 (Nucleoporin Nup96) (96 kDa nucleoporin)].

COPG_HUMAN
NC score	0.018074 (rank : 35)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	53	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

COPG2_MOUSE
NC score	0.017836 (rank : 36)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	53	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

K0179_HUMAN
NC score	0.017427 (rank : 37)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	53	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q14684, Q8TBZ4	Gene names	KIAA0179
Domain Architecture
Description	Protein KIAA0179.

RBP24_HUMAN
NC score	0.015975 (rank : 38)	θ value	0.279714 (rank : 29)
Query Neighborhood Hits	53	Target Neighborhood Hits	1559	Shared Neighborhood Hits	10
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

GCC2_HUMAN
NC score	0.015917 (rank : 39)	θ value	0.279714 (rank : 27)
Query Neighborhood Hits	53	Target Neighborhood Hits	1558	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

PDE6B_MOUSE
NC score	0.014557 (rank : 40)	θ value	1.06291 (rank : 34)
Query Neighborhood Hits	53	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

HMMR_HUMAN
NC score	0.013658 (rank : 41)	θ value	1.81305 (rank : 35)
Query Neighborhood Hits	53	Target Neighborhood Hits	1082	Shared Neighborhood Hits	12
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

CP135_MOUSE
NC score	0.012576 (rank : 42)	θ value	0.47712 (rank : 30)
Query Neighborhood Hits	53	Target Neighborhood Hits	1278	Shared Neighborhood Hits	10
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CCD37_MOUSE
NC score	0.012389 (rank : 43)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	53	Target Neighborhood Hits	199	Shared Neighborhood Hits	5
SwissProt Accessions	Q80VN0, Q6AXD6	Gene names	Ccdc37
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 37.

PHLB2_MOUSE
NC score	0.012218 (rank : 44)	θ value	2.36792 (rank : 37)
Query Neighborhood Hits	53	Target Neighborhood Hits	1016	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

K0056_HUMAN
NC score	0.011828 (rank : 45)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	53	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	P42695	Gene names	KIAA0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

HIP1_HUMAN
NC score	0.011759 (rank : 46)	θ value	1.06291 (rank : 32)
Query Neighborhood Hits	53	Target Neighborhood Hits	1016	Shared Neighborhood Hits	9
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

PDE6B_HUMAN
NC score	0.011747 (rank : 47)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	53	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

DIAP2_HUMAN
NC score	0.008765 (rank : 48)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	53	Target Neighborhood Hits	342	Shared Neighborhood Hits	7
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

RAI1_MOUSE
NC score	0.008517 (rank : 49)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	53	Target Neighborhood Hits	344	Shared Neighborhood Hits	2
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

URP1_HUMAN
NC score	0.008500 (rank : 50)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	53	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BQL6, Q8IX34, Q8IYH2, Q9NWM2, Q9NXQ3	Gene names	URP1, C20orf42, KIND1
Domain Architecture
Description	Unc-112-related protein 1 (Kindlin-1) (Kindlerin) (Kindlin syndrome protein).

DIAP2_MOUSE
NC score	0.007529 (rank : 51)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	53	Target Neighborhood Hits	260	Shared Neighborhood Hits	4
SwissProt Accessions	O70566, Q8C2G8	Gene names	Diaph2, Diap2
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) (mDia3).

MRCKA_HUMAN
NC score	0.001106 (rank : 52)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	53	Target Neighborhood Hits	1999	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

CDK9_MOUSE
NC score	-0.001757 (rank : 53)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	53	Target Neighborhood Hits	822	Shared Neighborhood Hits	4
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

PTK7_HUMAN
NC score	-0.002133 (rank : 54)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	53	Target Neighborhood Hits	1103	Shared Neighborhood Hits	4
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).