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Network neighborhood for query Sequence : CASP9_HUMAN

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CASP9_HUMAN
 
SwissProt Accessions P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8 Gene names CASP9, MCH6
Domain
Architecture
Description Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].
Rank Plots


Hits sorted by θ


CASP9_HUMAN
 
θ value 0 (rank : 1) NC score 0.999962 (rank : 1)
Query Neighborhood Hits 33 Target Neighborhood Hits 33 Shared Neighborhood Hits 33
SwissProt Accessions P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8 Gene names CASP9, MCH6
Domain
Architecture
Description Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].
CASP3_HUMAN
 
θ value 1.08726e-37 (rank : 2) NC score 0.936279 (rank : 2)
Query Neighborhood Hits 33 Target Neighborhood Hits 27 Shared Neighborhood Hits 22
SwissProt Accessions P42574, Q96AN1, Q96KP2 Gene names CASP3, CPP32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASP3_MOUSE
 
θ value 1.08726e-37 (rank : 3) NC score 0.936195 (rank : 3)
Query Neighborhood Hits 33 Target Neighborhood Hits 23 Shared Neighborhood Hits 22
SwissProt Accessions P70677, O08668, Q8CHV5, Q9QWI4 Gene names Casp3, Cpp32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASP2_MOUSE
 
θ value 1.57e-36 (rank : 4) NC score 0.911443 (rank : 6)
Query Neighborhood Hits 33 Target Neighborhood Hits 34 Shared Neighborhood Hits 22
SwissProt Accessions P29594, O08737, Q3TCM0, Q8C9H7, Q8K241 Gene names Casp2, Ich1, Nedd-2, Nedd2
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASP2_HUMAN
 
θ value 3.27365e-34 (rank : 5) NC score 0.909712 (rank : 7)
Query Neighborhood Hits 33 Target Neighborhood Hits 31 Shared Neighborhood Hits 22
SwissProt Accessions P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9 Gene names CASP2, ICH1
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASP8_HUMAN
 
θ value 6.17384e-33 (rank : 6) NC score 0.881557 (rank : 12)
Query Neighborhood Hits 33 Target Neighborhood Hits 62 Shared Neighborhood Hits 22
SwissProt Accessions Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81 Gene names CASP8, MCH5
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASP8_MOUSE
 
θ value 1.0531e-32 (rank : 7) NC score 0.888690 (rank : 10)
Query Neighborhood Hits 33 Target Neighborhood Hits 57 Shared Neighborhood Hits 22
SwissProt Accessions O89110, O35669 Gene names Casp8
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASP7_HUMAN
 
θ value 2.59387e-31 (rank : 8) NC score 0.920333 (rank : 5)
Query Neighborhood Hits 33 Target Neighborhood Hits 26 Shared Neighborhood Hits 22
SwissProt Accessions P55210, Q13364, Q96BA0 Gene names CASP7, MCH3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP7_MOUSE
 
θ value 3.74554e-30 (rank : 9) NC score 0.921932 (rank : 4)
Query Neighborhood Hits 33 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions P97864, O08669 Gene names Casp7, Lice2, Mch3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP6_MOUSE
 
θ value 1.12775e-26 (rank : 10) NC score 0.906067 (rank : 8)
Query Neighborhood Hits 33 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions O08738 Gene names Casp6
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASP6_HUMAN
 
θ value 1.62847e-25 (rank : 11) NC score 0.904507 (rank : 9)
Query Neighborhood Hits 33 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions P55212, Q9BQE7 Gene names CASP6, MCH2
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASPA_HUMAN
 
θ value 1.16704e-23 (rank : 12) NC score 0.882521 (rank : 11)
Query Neighborhood Hits 33 Target Neighborhood Hits 53 Shared Neighborhood Hits 22
SwissProt Accessions Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7 Gene names CASP10, MCH4
Domain
Architecture
Description Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].
CASPE_MOUSE
 
θ value 5.07402e-19 (rank : 13) NC score 0.879327 (rank : 13)
Query Neighborhood Hits 33 Target Neighborhood Hits 23 Shared Neighborhood Hits 22
SwissProt Accessions O89094 Gene names Casp14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
CASP1_MOUSE
 
θ value 4.29542e-18 (rank : 14) NC score 0.768279 (rank : 15)
Query Neighborhood Hits 33 Target Neighborhood Hits 38 Shared Neighborhood Hits 22
SwissProt Accessions P29452 Gene names Casp1, Il1bc
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASP1_HUMAN
 
θ value 1.63225e-17 (rank : 15) NC score 0.753705 (rank : 17)
Query Neighborhood Hits 33 Target Neighborhood Hits 41 Shared Neighborhood Hits 22
SwissProt Accessions P29466, Q9UCN3 Gene names CASP1, IL1BC, IL1BCE
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASPE_HUMAN
 
θ value 1.38178e-16 (rank : 16) NC score 0.873384 (rank : 14)
Query Neighborhood Hits 33 Target Neighborhood Hits 26 Shared Neighborhood Hits 21
SwissProt Accessions P31944, O95823, Q3SYC9 Gene names CASP14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
CASP4_MOUSE
 
θ value 6.41864e-14 (rank : 17) NC score 0.753837 (rank : 16)
Query Neighborhood Hits 33 Target Neighborhood Hits 28 Shared Neighborhood Hits 22
SwissProt Accessions P70343, O08735 Gene names Casp4, Casp11, Caspl, Ich3
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].
CASP5_HUMAN
 
θ value 4.16044e-13 (rank : 18) NC score 0.746895 (rank : 18)
Query Neighborhood Hits 33 Target Neighborhood Hits 28 Shared Neighborhood Hits 21
SwissProt Accessions P51878 Gene names CASP5, ICH3
Domain
Architecture
Description Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].
CASPC_MOUSE
 
θ value 4.16044e-13 (rank : 19) NC score 0.731565 (rank : 19)
Query Neighborhood Hits 33 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions O08736, Q3TT82 Gene names Casp12
Domain
Architecture
Description Caspase-12 precursor (EC 3.4.22.-) (CASP-12).
CASP4_HUMAN
 
θ value 5.43371e-13 (rank : 20) NC score 0.730560 (rank : 20)
Query Neighborhood Hits 33 Target Neighborhood Hits 23 Shared Neighborhood Hits 21
SwissProt Accessions P49662 Gene names CASP4, ICH2
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].
CFLAR_MOUSE
 
θ value 4.92598e-06 (rank : 21) NC score 0.585697 (rank : 22)
Query Neighborhood Hits 33 Target Neighborhood Hits 32 Shared Neighborhood Hits 19
SwissProt Accessions O35732, O35707, O35733 Gene names Cflar, Cash
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
CFLAR_HUMAN
 
θ value 8.40245e-06 (rank : 22) NC score 0.620466 (rank : 21)
Query Neighborhood Hits 33 Target Neighborhood Hits 47 Shared Neighborhood Hits 22
SwissProt Accessions O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1 Gene names CFLAR, CASH, CLARP, MRIT
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
AMACR_HUMAN
 
θ value 3.0926 (rank : 23) NC score 0.019904 (rank : 29)
Query Neighborhood Hits 33 Target Neighborhood Hits 6 Shared Neighborhood Hits 2
SwissProt Accessions Q9UHK6, O43673, Q9Y3Q1 Gene names AMACR
Domain
Architecture
Description Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase).
SPTA3_HUMAN
 
θ value 3.0926 (rank : 24) NC score 0.034090 (rank : 28)
Query Neighborhood Hits 33 Target Neighborhood Hits 15 Shared Neighborhood Hits 2
SwissProt Accessions Q8NHX4, Q86WX5, Q8N9Y6 Gene names SPATA3, TSARG1
Domain
Architecture

No domain graphic available

Description Spermatogenesis-associated protein 3 (Testis spermatocyte apoptosis- related protein 1) (Testis and spermatogenesis cell-related protein 1).
K0141_HUMAN
 
θ value 6.88961 (rank : 25) NC score 0.013534 (rank : 32)
Query Neighborhood Hits 33 Target Neighborhood Hits 30 Shared Neighborhood Hits 2
SwissProt Accessions Q14154, Q969R4, Q96EU9 Gene names KIAA0141
Domain
Architecture
Description Protein KIAA0141.
P73L_HUMAN
 
θ value 6.88961 (rank : 26) NC score 0.014752 (rank : 31)
Query Neighborhood Hits 33 Target Neighborhood Hits 102 Shared Neighborhood Hits 3
SwissProt Accessions Q9H3D4, O75080, O75195, O75922, O76078, Q6VEG2, Q6VEG3, Q6VEG4, Q6VFJ1, Q6VFJ2, Q6VFJ3, Q6VH20, Q7LDI3, Q7LDI4, Q7LDI5, Q96KR0, Q9H3D2, Q9H3D3, Q9H3P8, Q9NPH7, Q9P1B4, Q9P1B5, Q9P1B6, Q9P1B7, Q9UBV9, Q9UE10, Q9UP26, Q9UP27, Q9UP28, Q9UP74 Gene names TP73L, KET, P63, P73H, P73L
Domain
Architecture

No domain graphic available

Description Tumor protein p73-like (p73L) (p63) (Tumor protein 63) (TP63) (p51) (p40) (Keratinocyte transcription factor KET) (Chronic ulcerative stomatitis protein) (CUSP).
P73L_MOUSE
 
θ value 6.88961 (rank : 27) NC score 0.014806 (rank : 30)
Query Neighborhood Hits 33 Target Neighborhood Hits 88 Shared Neighborhood Hits 3
SwissProt Accessions O88898, O88897, O88899, O89097, Q8C826, Q9QWY9, Q9QWZ0 Gene names Tp73l, P63, P73l, Trp63
Domain
Architecture

No domain graphic available

Description Tumor protein p73-like (p73L) (p63) (Transformation-related protein 63).
SFR16_MOUSE
 
θ value 6.88961 (rank : 28) NC score 0.012736 (rank : 33)
Query Neighborhood Hits 33 Target Neighborhood Hits 177 Shared Neighborhood Hits 2
SwissProt Accessions Q8CFC7, Q8CFC8, Q9Z2N3 Gene names Sfrs16, Clasp, Swap2
Domain
Architecture

No domain graphic available

Description Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).
TGM1_MOUSE
 
θ value 6.88961 (rank : 29) NC score 0.005786 (rank : 36)
Query Neighborhood Hits 33 Target Neighborhood Hits 25 Shared Neighborhood Hits 2
SwissProt Accessions Q9JLF6, Q8R0T9 Gene names Tgm1
Domain
Architecture

No domain graphic available

Description Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Transglutaminase K) (TGase K) (TGK) (TG(K)) (Transglutaminase-1) (Epidermal TGase).
LGP2_MOUSE
 
θ value 8.99809 (rank : 30) NC score 0.006166 (rank : 35)
Query Neighborhood Hits 33 Target Neighborhood Hits 86 Shared Neighborhood Hits 2
SwissProt Accessions Q99J87, Q9D1X4 Gene names Lgp2, D11lgp2e
Domain
Architecture

No domain graphic available

Description Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).
NKX22_MOUSE
 
θ value 8.99809 (rank : 31) NC score 0.001398 (rank : 38)
Query Neighborhood Hits 33 Target Neighborhood Hits 336 Shared Neighborhood Hits 2
SwissProt Accessions P42586 Gene names Nkx2-2, Nkx-2.2, Nkx2b
Domain
Architecture
Description Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B).
SAFB1_HUMAN
 
θ value 8.99809 (rank : 32) NC score 0.007837 (rank : 34)
Query Neighborhood Hits 33 Target Neighborhood Hits 493 Shared Neighborhood Hits 3
SwissProt Accessions Q15424, O60406, Q59HH8 Gene names SAFB, HAP, HET, SAFB1
Domain
Architecture
Description Scaffold attachment factor B (Scaffold attachment factor B1) (SAF-B) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE- TATA-binding protein).
SAFB2_HUMAN
 
θ value 8.99809 (rank : 33) NC score 0.005570 (rank : 37)
Query Neighborhood Hits 33 Target Neighborhood Hits 720 Shared Neighborhood Hits 3
SwissProt Accessions Q14151, Q8TB13 Gene names SAFB2, KIAA0138
Domain
Architecture
Description Scaffold attachment factor B2.
FADD_HUMAN
 
θ value θ > 10 (rank : 34) NC score 0.118493 (rank : 24)
Query Neighborhood Hits 33 Target Neighborhood Hits 20 Shared Neighborhood Hits 5
SwissProt Accessions Q13158, Q14866 Gene names FADD, MORT1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
FADD_MOUSE
 
θ value θ > 10 (rank : 35) NC score 0.099931 (rank : 25)
Query Neighborhood Hits 33 Target Neighborhood Hits 23 Shared Neighborhood Hits 5
SwissProt Accessions Q61160, Q3TC37, Q61082 Gene names Fadd, Mort1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
ICBR_HUMAN
 
θ value θ > 10 (rank : 36) NC score 0.158569 (rank : 23)
Query Neighborhood Hits 33 Target Neighborhood Hits 11 Shared Neighborhood Hits 3
SwissProt Accessions P57730 Gene names ICEBERG
Domain
Architecture
Description Caspase-1 inhibitor Iceberg.
PEA15_HUMAN
 
θ value θ > 10 (rank : 37) NC score 0.068624 (rank : 27)
Query Neighborhood Hits 33 Target Neighborhood Hits 10 Shared Neighborhood Hits 3
SwissProt Accessions Q15121, O00511 Gene names PEA15
Domain
Architecture
Description Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes) (PED).
PEA15_MOUSE
 
θ value θ > 10 (rank : 38) NC score 0.069332 (rank : 26)
Query Neighborhood Hits 33 Target Neighborhood Hits 7 Shared Neighborhood Hits 3
SwissProt Accessions Q62048, Q3U5N7 Gene names Pea15
Domain
Architecture
Description Astrocytic phosphoprotein PEA-15.

Hits sorted by NC score


CASP9_HUMAN
 
NC score 0.999962 (rank : 1) θ value 0 (rank : 1)
Query Neighborhood Hits 33 Target Neighborhood Hits 33 Shared Neighborhood Hits 33
SwissProt Accessions P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8 Gene names CASP9, MCH6
Domain
Architecture
Description Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].
CASP3_HUMAN
 
NC score 0.936279 (rank : 2) θ value 1.08726e-37 (rank : 2)
Query Neighborhood Hits 33 Target Neighborhood Hits 27 Shared Neighborhood Hits 22
SwissProt Accessions P42574, Q96AN1, Q96KP2 Gene names CASP3, CPP32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASP3_MOUSE
 
NC score 0.936195 (rank : 3) θ value 1.08726e-37 (rank : 3)
Query Neighborhood Hits 33 Target Neighborhood Hits 23 Shared Neighborhood Hits 22
SwissProt Accessions P70677, O08668, Q8CHV5, Q9QWI4 Gene names Casp3, Cpp32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASP7_MOUSE
 
NC score 0.921932 (rank : 4) θ value 3.74554e-30 (rank : 9)
Query Neighborhood Hits 33 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions P97864, O08669 Gene names Casp7, Lice2, Mch3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP7_HUMAN
 
NC score 0.920333 (rank : 5) θ value 2.59387e-31 (rank : 8)
Query Neighborhood Hits 33 Target Neighborhood Hits 26 Shared Neighborhood Hits 22
SwissProt Accessions P55210, Q13364, Q96BA0 Gene names CASP7, MCH3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP2_MOUSE
 
NC score 0.911443 (rank : 6) θ value 1.57e-36 (rank : 4)
Query Neighborhood Hits 33 Target Neighborhood Hits 34 Shared Neighborhood Hits 22
SwissProt Accessions P29594, O08737, Q3TCM0, Q8C9H7, Q8K241 Gene names Casp2, Ich1, Nedd-2, Nedd2
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASP2_HUMAN
 
NC score 0.909712 (rank : 7) θ value 3.27365e-34 (rank : 5)
Query Neighborhood Hits 33 Target Neighborhood Hits 31 Shared Neighborhood Hits 22
SwissProt Accessions P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9 Gene names CASP2, ICH1
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASP6_MOUSE
 
NC score 0.906067 (rank : 8) θ value 1.12775e-26 (rank : 10)
Query Neighborhood Hits 33 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions O08738 Gene names Casp6
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASP6_HUMAN
 
NC score 0.904507 (rank : 9) θ value 1.62847e-25 (rank : 11)
Query Neighborhood Hits 33 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions P55212, Q9BQE7 Gene names CASP6, MCH2
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASP8_MOUSE
 
NC score 0.888690 (rank : 10) θ value 1.0531e-32 (rank : 7)
Query Neighborhood Hits 33 Target Neighborhood Hits 57 Shared Neighborhood Hits 22
SwissProt Accessions O89110, O35669 Gene names Casp8
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASPA_HUMAN
 
NC score 0.882521 (rank : 11) θ value 1.16704e-23 (rank : 12)
Query Neighborhood Hits 33 Target Neighborhood Hits 53 Shared Neighborhood Hits 22
SwissProt Accessions Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7 Gene names CASP10, MCH4
Domain
Architecture
Description Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].
CASP8_HUMAN
 
NC score 0.881557 (rank : 12) θ value 6.17384e-33 (rank : 6)
Query Neighborhood Hits 33 Target Neighborhood Hits 62 Shared Neighborhood Hits 22
SwissProt Accessions Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81 Gene names CASP8, MCH5
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASPE_MOUSE
 
NC score 0.879327 (rank : 13) θ value 5.07402e-19 (rank : 13)
Query Neighborhood Hits 33 Target Neighborhood Hits 23 Shared Neighborhood Hits 22
SwissProt Accessions O89094 Gene names Casp14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
CASPE_HUMAN
 
NC score 0.873384 (rank : 14) θ value 1.38178e-16 (rank : 16)
Query Neighborhood Hits 33 Target Neighborhood Hits 26 Shared Neighborhood Hits 21
SwissProt Accessions P31944, O95823, Q3SYC9 Gene names CASP14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
CASP1_MOUSE
 
NC score 0.768279 (rank : 15) θ value 4.29542e-18 (rank : 14)
Query Neighborhood Hits 33 Target Neighborhood Hits 38 Shared Neighborhood Hits 22
SwissProt Accessions P29452 Gene names Casp1, Il1bc
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASP4_MOUSE
 
NC score 0.753837 (rank : 16) θ value 6.41864e-14 (rank : 17)
Query Neighborhood Hits 33 Target Neighborhood Hits 28 Shared Neighborhood Hits 22
SwissProt Accessions P70343, O08735 Gene names Casp4, Casp11, Caspl, Ich3
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].
CASP1_HUMAN
 
NC score 0.753705 (rank : 17) θ value 1.63225e-17 (rank : 15)
Query Neighborhood Hits 33 Target Neighborhood Hits 41 Shared Neighborhood Hits 22
SwissProt Accessions P29466, Q9UCN3 Gene names CASP1, IL1BC, IL1BCE
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASP5_HUMAN
 
NC score 0.746895 (rank : 18) θ value 4.16044e-13 (rank : 18)
Query Neighborhood Hits 33 Target Neighborhood Hits 28 Shared Neighborhood Hits 21
SwissProt Accessions P51878 Gene names CASP5, ICH3
Domain
Architecture
Description Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].
CASPC_MOUSE
 
NC score 0.731565 (rank : 19) θ value 4.16044e-13 (rank : 19)
Query Neighborhood Hits 33 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions O08736, Q3TT82 Gene names Casp12
Domain
Architecture
Description Caspase-12 precursor (EC 3.4.22.-) (CASP-12).
CASP4_HUMAN
 
NC score 0.730560 (rank : 20) θ value 5.43371e-13 (rank : 20)
Query Neighborhood Hits 33 Target Neighborhood Hits 23 Shared Neighborhood Hits 21
SwissProt Accessions P49662 Gene names CASP4, ICH2
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].
CFLAR_HUMAN
 
NC score 0.620466 (rank : 21) θ value 8.40245e-06 (rank : 22)
Query Neighborhood Hits 33 Target Neighborhood Hits 47 Shared Neighborhood Hits 22
SwissProt Accessions O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1 Gene names CFLAR, CASH, CLARP, MRIT
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
CFLAR_MOUSE
 
NC score 0.585697 (rank : 22) θ value 4.92598e-06 (rank : 21)
Query Neighborhood Hits 33 Target Neighborhood Hits 32 Shared Neighborhood Hits 19
SwissProt Accessions O35732, O35707, O35733 Gene names Cflar, Cash
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
ICBR_HUMAN
 
NC score 0.158569 (rank : 23) θ value θ > 10 (rank : 36)
Query Neighborhood Hits 33 Target Neighborhood Hits 11 Shared Neighborhood Hits 3
SwissProt Accessions P57730 Gene names ICEBERG
Domain
Architecture
Description Caspase-1 inhibitor Iceberg.
FADD_HUMAN
 
NC score 0.118493 (rank : 24) θ value θ > 10 (rank : 34)
Query Neighborhood Hits 33 Target Neighborhood Hits 20 Shared Neighborhood Hits 5
SwissProt Accessions Q13158, Q14866 Gene names FADD, MORT1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
FADD_MOUSE
 
NC score 0.099931 (rank : 25) θ value θ > 10 (rank : 35)
Query Neighborhood Hits 33 Target Neighborhood Hits 23 Shared Neighborhood Hits 5
SwissProt Accessions Q61160, Q3TC37, Q61082 Gene names Fadd, Mort1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
PEA15_MOUSE
 
NC score 0.069332 (rank : 26) θ value θ > 10 (rank : 38)
Query Neighborhood Hits 33 Target Neighborhood Hits 7 Shared Neighborhood Hits 3
SwissProt Accessions Q62048, Q3U5N7 Gene names Pea15
Domain
Architecture
Description Astrocytic phosphoprotein PEA-15.
PEA15_HUMAN
 
NC score 0.068624 (rank : 27) θ value θ > 10 (rank : 37)
Query Neighborhood Hits 33 Target Neighborhood Hits 10 Shared Neighborhood Hits 3
SwissProt Accessions Q15121, O00511 Gene names PEA15
Domain
Architecture
Description Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes) (PED).
SPTA3_HUMAN
 
NC score 0.034090 (rank : 28) θ value 3.0926 (rank : 24)
Query Neighborhood Hits 33 Target Neighborhood Hits 15 Shared Neighborhood Hits 2
SwissProt Accessions Q8NHX4, Q86WX5, Q8N9Y6 Gene names SPATA3, TSARG1
Domain
Architecture

No domain graphic available

Description Spermatogenesis-associated protein 3 (Testis spermatocyte apoptosis- related protein 1) (Testis and spermatogenesis cell-related protein 1).
AMACR_HUMAN
 
NC score 0.019904 (rank : 29) θ value 3.0926 (rank : 23)
Query Neighborhood Hits 33 Target Neighborhood Hits 6 Shared Neighborhood Hits 2
SwissProt Accessions Q9UHK6, O43673, Q9Y3Q1 Gene names AMACR
Domain
Architecture
Description Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase).
P73L_MOUSE
 
NC score 0.014806 (rank : 30) θ value 6.88961 (rank : 27)
Query Neighborhood Hits 33 Target Neighborhood Hits 88 Shared Neighborhood Hits 3
SwissProt Accessions O88898, O88897, O88899, O89097, Q8C826, Q9QWY9, Q9QWZ0 Gene names Tp73l, P63, P73l, Trp63
Domain
Architecture

No domain graphic available

Description Tumor protein p73-like (p73L) (p63) (Transformation-related protein 63).
P73L_HUMAN
 
NC score 0.014752 (rank : 31) θ value 6.88961 (rank : 26)
Query Neighborhood Hits 33 Target Neighborhood Hits 102 Shared Neighborhood Hits 3
SwissProt Accessions Q9H3D4, O75080, O75195, O75922, O76078, Q6VEG2, Q6VEG3, Q6VEG4, Q6VFJ1, Q6VFJ2, Q6VFJ3, Q6VH20, Q7LDI3, Q7LDI4, Q7LDI5, Q96KR0, Q9H3D2, Q9H3D3, Q9H3P8, Q9NPH7, Q9P1B4, Q9P1B5, Q9P1B6, Q9P1B7, Q9UBV9, Q9UE10, Q9UP26, Q9UP27, Q9UP28, Q9UP74 Gene names TP73L, KET, P63, P73H, P73L
Domain
Architecture

No domain graphic available

Description Tumor protein p73-like (p73L) (p63) (Tumor protein 63) (TP63) (p51) (p40) (Keratinocyte transcription factor KET) (Chronic ulcerative stomatitis protein) (CUSP).
K0141_HUMAN
 
NC score 0.013534 (rank : 32) θ value 6.88961 (rank : 25)
Query Neighborhood Hits 33 Target Neighborhood Hits 30 Shared Neighborhood Hits 2
SwissProt Accessions Q14154, Q969R4, Q96EU9 Gene names KIAA0141
Domain
Architecture
Description Protein KIAA0141.
SFR16_MOUSE
 
NC score 0.012736 (rank : 33) θ value 6.88961 (rank : 28)
Query Neighborhood Hits 33 Target Neighborhood Hits 177 Shared Neighborhood Hits 2
SwissProt Accessions Q8CFC7, Q8CFC8, Q9Z2N3 Gene names Sfrs16, Clasp, Swap2
Domain
Architecture

No domain graphic available

Description Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).
SAFB1_HUMAN
 
NC score 0.007837 (rank : 34) θ value 8.99809 (rank : 32)
Query Neighborhood Hits 33 Target Neighborhood Hits 493 Shared Neighborhood Hits 3
SwissProt Accessions Q15424, O60406, Q59HH8 Gene names SAFB, HAP, HET, SAFB1
Domain
Architecture
Description Scaffold attachment factor B (Scaffold attachment factor B1) (SAF-B) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE- TATA-binding protein).
LGP2_MOUSE
 
NC score 0.006166 (rank : 35) θ value 8.99809 (rank : 30)
Query Neighborhood Hits 33 Target Neighborhood Hits 86 Shared Neighborhood Hits 2
SwissProt Accessions Q99J87, Q9D1X4 Gene names Lgp2, D11lgp2e
Domain
Architecture

No domain graphic available

Description Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).
TGM1_MOUSE
 
NC score 0.005786 (rank : 36) θ value 6.88961 (rank : 29)
Query Neighborhood Hits 33 Target Neighborhood Hits 25 Shared Neighborhood Hits 2
SwissProt Accessions Q9JLF6, Q8R0T9 Gene names Tgm1
Domain
Architecture

No domain graphic available

Description Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Transglutaminase K) (TGase K) (TGK) (TG(K)) (Transglutaminase-1) (Epidermal TGase).
SAFB2_HUMAN
 
NC score 0.005570 (rank : 37) θ value 8.99809 (rank : 33)
Query Neighborhood Hits 33 Target Neighborhood Hits 720 Shared Neighborhood Hits 3
SwissProt Accessions Q14151, Q8TB13 Gene names SAFB2, KIAA0138
Domain
Architecture
Description Scaffold attachment factor B2.
NKX22_MOUSE
 
NC score 0.001398 (rank : 38) θ value 8.99809 (rank : 31)
Query Neighborhood Hits 33 Target Neighborhood Hits 336 Shared Neighborhood Hits 2
SwissProt Accessions P42586 Gene names Nkx2-2, Nkx-2.2, Nkx2b
Domain
Architecture
Description Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B).