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Network neighborhood for query Sequence : FADD_HUMAN

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FADD_HUMAN
SwissProt Accessions	Q13158, Q14866	Gene names	FADD, MORT1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FADD_HUMAN
θ value	1.18825e-76 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q13158, Q14866	Gene names	FADD, MORT1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

FADD_MOUSE
θ value	3.0428e-56 (rank : 2)	NC score	0.961678 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

CASP8_MOUSE
θ value	9.92553e-07 (rank : 3)	NC score	0.302427 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	57	Shared Neighborhood Hits	7
SwissProt Accessions	O89110, O35669	Gene names	Casp8
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

ANK1_HUMAN
θ value	1.09739e-05 (rank : 4)	NC score	0.139090 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	416	Shared Neighborhood Hits	8
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

CASP8_HUMAN
θ value	1.09739e-05 (rank : 5)	NC score	0.296855 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81	Gene names	CASP8, MCH5
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

ANK1_MOUSE
θ value	3.19293e-05 (rank : 6)	NC score	0.140684 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	430	Shared Neighborhood Hits	9
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

RIPK1_MOUSE
θ value	4.1701e-05 (rank : 7)	NC score	0.069830 (rank : 29)
Query Neighborhood Hits	20	Target Neighborhood Hits	874	Shared Neighborhood Hits	9
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

CASPA_HUMAN
θ value	9.29e-05 (rank : 8)	NC score	0.274936 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	53	Shared Neighborhood Hits	7
SwissProt Accessions	Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7	Gene names	CASP10, MCH4
Domain Architecture
Description	Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].

RIPK1_HUMAN
θ value	0.000121331 (rank : 9)	NC score	0.067770 (rank : 32)
Query Neighborhood Hits	20	Target Neighborhood Hits	891	Shared Neighborhood Hits	10
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

ANK2_HUMAN
θ value	0.00509761 (rank : 10)	NC score	0.126239 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	1615	Shared Neighborhood Hits	12
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CFLAR_HUMAN
θ value	0.0148317 (rank : 11)	NC score	0.252097 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	47	Shared Neighborhood Hits	7
SwissProt Accessions	O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1	Gene names	CFLAR, CASH, CLARP, MRIT
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

ANK3_HUMAN
θ value	0.0431538 (rank : 12)	NC score	0.127528 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	853	Shared Neighborhood Hits	12
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

CRADD_HUMAN
θ value	0.365318 (rank : 13)	NC score	0.100934 (rank : 23)
Query Neighborhood Hits	20	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	P78560	Gene names	CRADD, RAIDD
Domain Architecture
Description	Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain).

DYH11_HUMAN
θ value	0.47712 (rank : 14)	NC score	0.037801 (rank : 67)
Query Neighborhood Hits	20	Target Neighborhood Hits	234	Shared Neighborhood Hits	2
SwissProt Accessions	Q96DT5, Q9UJ82	Gene names	DNAH11
Domain Architecture
Description	Ciliary dynein heavy chain 11 (Axonemal beta dynein heavy chain 11).

CFLAR_MOUSE
θ value	0.62314 (rank : 15)	NC score	0.234749 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	O35732, O35707, O35733	Gene names	Cflar, Cash
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

TNR1A_MOUSE
θ value	1.06291 (rank : 16)	NC score	0.086142 (rank : 26)
Query Neighborhood Hits	20	Target Neighborhood Hits	131	Shared Neighborhood Hits	7
SwissProt Accessions	P25118	Gene names	Tnfrsf1a, Tnfr-1, Tnfr1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55).

TR10B_MOUSE
θ value	1.38821 (rank : 17)	NC score	0.069532 (rank : 30)
Query Neighborhood Hits	20	Target Neighborhood Hits	76	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZM4, Q9JJL5, Q9JJL6	Gene names	Tnfrsf10b, Dr5, Killer
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10B precursor (Death receptor 5) (MK).

TNR1A_HUMAN
θ value	3.0926 (rank : 18)	NC score	0.083094 (rank : 27)
Query Neighborhood Hits	20	Target Neighborhood Hits	121	Shared Neighborhood Hits	10
SwissProt Accessions	P19438	Gene names	TNFRSF1A, TNFAR, TNFR1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55) (CD120a antigen) [Contains: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)].

CRADD_MOUSE
θ value	5.27518 (rank : 19)	NC score	0.080247 (rank : 28)
Query Neighborhood Hits	20	Target Neighborhood Hits	11	Shared Neighborhood Hits	5
SwissProt Accessions	O88843, Q9QUN0	Gene names	Cradd, Raidd
Domain Architecture
Description	Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain).

CJ092_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.062997 (rank : 34)
Query Neighborhood Hits	20	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IYW2, Q5JSF7, Q9NTQ5	Gene names	C10orf92
Domain Architecture	No domain graphic available
Description	Protein C10orf92.

ANFY1_HUMAN
θ value	θ > 10 (rank : 21)	NC score	0.057749 (rank : 45)
Query Neighborhood Hits	20	Target Neighborhood Hits	480	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_MOUSE
θ value	θ > 10 (rank : 22)	NC score	0.057441 (rank : 47)
Query Neighborhood Hits	20	Target Neighborhood Hits	480	Shared Neighborhood Hits	4
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANKS6_HUMAN
θ value	θ > 10 (rank : 23)	NC score	0.052356 (rank : 60)
Query Neighborhood Hits	20	Target Neighborhood Hits	411	Shared Neighborhood Hits	4
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

ANKS6_MOUSE
θ value	θ > 10 (rank : 24)	NC score	0.053604 (rank : 55)
Query Neighborhood Hits	20	Target Neighborhood Hits	435	Shared Neighborhood Hits	4
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

ANKY1_HUMAN
θ value	θ > 10 (rank : 25)	NC score	0.055091 (rank : 51)
Query Neighborhood Hits	20	Target Neighborhood Hits	248	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

ANR16_HUMAN
θ value	θ > 10 (rank : 26)	NC score	0.055812 (rank : 49)
Query Neighborhood Hits	20	Target Neighborhood Hits	286	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P6B7, Q9NT01	Gene names	ANKRD16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 16.

ANR22_HUMAN
θ value	θ > 10 (rank : 27)	NC score	0.054523 (rank : 53)
Query Neighborhood Hits	20	Target Neighborhood Hits	243	Shared Neighborhood Hits	4
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

ANR28_HUMAN
θ value	θ > 10 (rank : 28)	NC score	0.057908 (rank : 43)
Query Neighborhood Hits	20	Target Neighborhood Hits	314	Shared Neighborhood Hits	4
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR28_MOUSE
θ value	θ > 10 (rank : 29)	NC score	0.057381 (rank : 48)
Query Neighborhood Hits	20	Target Neighborhood Hits	314	Shared Neighborhood Hits	4
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR29_HUMAN
θ value	θ > 10 (rank : 30)	NC score	0.050674 (rank : 62)
Query Neighborhood Hits	20	Target Neighborhood Hits	294	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N6D5, Q6ZWE8, Q96LU9	Gene names	ANKRD29
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 29.

ANR42_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.050028 (rank : 66)
Query Neighborhood Hits	20	Target Neighborhood Hits	284	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANR42_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.053116 (rank : 57)
Query Neighborhood Hits	20	Target Neighborhood Hits	334	Shared Neighborhood Hits	4
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANR44_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.057856 (rank : 44)
Query Neighborhood Hits	20	Target Neighborhood Hits	318	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

ANR50_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.060596 (rank : 39)
Query Neighborhood Hits	20	Target Neighborhood Hits	361	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

ANR52_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.058145 (rank : 41)
Query Neighborhood Hits	20	Target Neighborhood Hits	322	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANR52_MOUSE
θ value	θ > 10 (rank : 36)	NC score	0.057972 (rank : 42)
Query Neighborhood Hits	20	Target Neighborhood Hits	318	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ASB14_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.050481 (rank : 63)
Query Neighborhood Hits	20	Target Neighborhood Hits	293	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VHS7	Gene names	Asb14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

ASB15_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.052966 (rank : 58)
Query Neighborhood Hits	20	Target Neighborhood Hits	305	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WXK1	Gene names	ASB15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

ASB15_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.053671 (rank : 54)
Query Neighborhood Hits	20	Target Neighborhood Hits	292	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VHS6	Gene names	Asb15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

ASB3_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.050442 (rank : 65)
Query Neighborhood Hits	20	Target Neighborhood Hits	316	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y575, Q9NVZ2	Gene names	ASB3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ASB3_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.051754 (rank : 61)
Query Neighborhood Hits	20	Target Neighborhood Hits	316	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

CASP1_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.063762 (rank : 33)
Query Neighborhood Hits	20	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	P29466, Q9UCN3	Gene names	CASP1, IL1BC, IL1BCE
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CASP1_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.068437 (rank : 31)
Query Neighborhood Hits	20	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	P29452	Gene names	Casp1, Il1bc
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CASP2_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.110157 (rank : 21)
Query Neighborhood Hits	20	Target Neighborhood Hits	31	Shared Neighborhood Hits	7
SwissProt Accessions	P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9	Gene names	CASP2, ICH1
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP2_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.108731 (rank : 22)
Query Neighborhood Hits	20	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	P29594, O08737, Q3TCM0, Q8C9H7, Q8K241	Gene names	Casp2, Ich1, Nedd-2, Nedd2
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP3_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.116610 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	27	Shared Neighborhood Hits	5
SwissProt Accessions	P42574, Q96AN1, Q96KP2	Gene names	CASP3, CPP32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP3_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.117556 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	P70677, O08668, Q8CHV5, Q9QWI4	Gene names	Casp3, Cpp32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP4_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.052570 (rank : 59)
Query Neighborhood Hits	20	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	P49662	Gene names	CASP4, ICH2
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].

CASP4_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.062413 (rank : 35)
Query Neighborhood Hits	20	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	P70343, O08735	Gene names	Casp4, Casp11, Caspl, Ich3
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].

CASP5_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.062090 (rank : 36)
Query Neighborhood Hits	20	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	P51878	Gene names	CASP5, ICH3
Domain Architecture
Description	Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].

CASP6_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.116410 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	P55212, Q9BQE7	Gene names	CASP6, MCH2
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP6_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.116164 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	O08738	Gene names	Casp6
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP7_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.123354 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	P55210, Q13364, Q96BA0	Gene names	CASP7, MCH3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP7_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.125108 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	P97864, O08669	Gene names	Casp7, Lice2, Mch3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP9_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.118493 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8	Gene names	CASP9, MCH6
Domain Architecture
Description	Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].

CASPC_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.050447 (rank : 64)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	O08736, Q3TT82	Gene names	Casp12
Domain Architecture
Description	Caspase-12 precursor (EC 3.4.22.-) (CASP-12).

CASPE_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.092452 (rank : 24)
Query Neighborhood Hits	20	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	P31944, O95823, Q3SYC9	Gene names	CASP14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

CASPE_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.091083 (rank : 25)
Query Neighborhood Hits	20	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	O89094	Gene names	Casp14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

CT086_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.053154 (rank : 56)
Query Neighborhood Hits	20	Target Neighborhood Hits	277	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

INVS_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.054845 (rank : 52)
Query Neighborhood Hits	20	Target Neighborhood Hits	455	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

INVS_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.055605 (rank : 50)
Query Neighborhood Hits	20	Target Neighborhood Hits	609	Shared Neighborhood Hits	4
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

PEA15_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.137249 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q15121, O00511	Gene names	PEA15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes) (PED).

PEA15_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.136241 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	Q62048, Q3U5N7	Gene names	Pea15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15.

TNKS1_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.061850 (rank : 38)
Query Neighborhood Hits	20	Target Neighborhood Hits	477	Shared Neighborhood Hits	4
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

TNKS2_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.061887 (rank : 37)
Query Neighborhood Hits	20	Target Neighborhood Hits	361	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

TRPA1_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.058600 (rank : 40)
Query Neighborhood Hits	20	Target Neighborhood Hits	339	Shared Neighborhood Hits	4
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

TRPA1_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.057651 (rank : 46)
Query Neighborhood Hits	20	Target Neighborhood Hits	343	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

Hits sorted by NC score

FADD_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.18825e-76 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q13158, Q14866	Gene names	FADD, MORT1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

FADD_MOUSE
NC score	0.961678 (rank : 2)	θ value	3.0428e-56 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

CASP8_MOUSE
NC score	0.302427 (rank : 3)	θ value	9.92553e-07 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	57	Shared Neighborhood Hits	7
SwissProt Accessions	O89110, O35669	Gene names	Casp8
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CASP8_HUMAN
NC score	0.296855 (rank : 4)	θ value	1.09739e-05 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81	Gene names	CASP8, MCH5
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CASPA_HUMAN
NC score	0.274936 (rank : 5)	θ value	9.29e-05 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	53	Shared Neighborhood Hits	7
SwissProt Accessions	Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7	Gene names	CASP10, MCH4
Domain Architecture
Description	Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].

CFLAR_HUMAN
NC score	0.252097 (rank : 6)	θ value	0.0148317 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	47	Shared Neighborhood Hits	7
SwissProt Accessions	O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1	Gene names	CFLAR, CASH, CLARP, MRIT
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

CFLAR_MOUSE
NC score	0.234749 (rank : 7)	θ value	0.62314 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	O35732, O35707, O35733	Gene names	Cflar, Cash
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

ANK1_MOUSE
NC score	0.140684 (rank : 8)	θ value	3.19293e-05 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	430	Shared Neighborhood Hits	9
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANK1_HUMAN
NC score	0.139090 (rank : 9)	θ value	1.09739e-05 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	416	Shared Neighborhood Hits	8
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

PEA15_HUMAN
NC score	0.137249 (rank : 10)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	20	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q15121, O00511	Gene names	PEA15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes) (PED).

PEA15_MOUSE
NC score	0.136241 (rank : 11)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	20	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	Q62048, Q3U5N7	Gene names	Pea15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15.

ANK3_HUMAN
NC score	0.127528 (rank : 12)	θ value	0.0431538 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	853	Shared Neighborhood Hits	12
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ANK2_HUMAN
NC score	0.126239 (rank : 13)	θ value	0.00509761 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	1615	Shared Neighborhood Hits	12
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CASP7_MOUSE
NC score	0.125108 (rank : 14)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	P97864, O08669	Gene names	Casp7, Lice2, Mch3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP7_HUMAN
NC score	0.123354 (rank : 15)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	20	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	P55210, Q13364, Q96BA0	Gene names	CASP7, MCH3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP9_HUMAN
NC score	0.118493 (rank : 16)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	20	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8	Gene names	CASP9, MCH6
Domain Architecture
Description	Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].

CASP3_MOUSE
NC score	0.117556 (rank : 17)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	20	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	P70677, O08668, Q8CHV5, Q9QWI4	Gene names	Casp3, Cpp32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP3_HUMAN
NC score	0.116610 (rank : 18)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	20	Target Neighborhood Hits	27	Shared Neighborhood Hits	5
SwissProt Accessions	P42574, Q96AN1, Q96KP2	Gene names	CASP3, CPP32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP6_HUMAN
NC score	0.116410 (rank : 19)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	P55212, Q9BQE7	Gene names	CASP6, MCH2
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP6_MOUSE
NC score	0.116164 (rank : 20)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	O08738	Gene names	Casp6
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP2_HUMAN
NC score	0.110157 (rank : 21)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	20	Target Neighborhood Hits	31	Shared Neighborhood Hits	7
SwissProt Accessions	P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9	Gene names	CASP2, ICH1
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP2_MOUSE
NC score	0.108731 (rank : 22)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	20	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	P29594, O08737, Q3TCM0, Q8C9H7, Q8K241	Gene names	Casp2, Ich1, Nedd-2, Nedd2
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CRADD_HUMAN
NC score	0.100934 (rank : 23)	θ value	0.365318 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	P78560	Gene names	CRADD, RAIDD
Domain Architecture
Description	Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain).

CASPE_HUMAN
NC score	0.092452 (rank : 24)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	20	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	P31944, O95823, Q3SYC9	Gene names	CASP14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

CASPE_MOUSE
NC score	0.091083 (rank : 25)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	20	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	O89094	Gene names	Casp14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

TNR1A_MOUSE
NC score	0.086142 (rank : 26)	θ value	1.06291 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	131	Shared Neighborhood Hits	7
SwissProt Accessions	P25118	Gene names	Tnfrsf1a, Tnfr-1, Tnfr1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55).

TNR1A_HUMAN
NC score	0.083094 (rank : 27)	θ value	3.0926 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	121	Shared Neighborhood Hits	10
SwissProt Accessions	P19438	Gene names	TNFRSF1A, TNFAR, TNFR1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55) (CD120a antigen) [Contains: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)].

CRADD_MOUSE
NC score	0.080247 (rank : 28)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	11	Shared Neighborhood Hits	5
SwissProt Accessions	O88843, Q9QUN0	Gene names	Cradd, Raidd
Domain Architecture
Description	Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain).

RIPK1_MOUSE
NC score	0.069830 (rank : 29)	θ value	4.1701e-05 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	874	Shared Neighborhood Hits	9
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

TR10B_MOUSE
NC score	0.069532 (rank : 30)	θ value	1.38821 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	76	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZM4, Q9JJL5, Q9JJL6	Gene names	Tnfrsf10b, Dr5, Killer
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10B precursor (Death receptor 5) (MK).

CASP1_MOUSE
NC score	0.068437 (rank : 31)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	20	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	P29452	Gene names	Casp1, Il1bc
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

RIPK1_HUMAN
NC score	0.067770 (rank : 32)	θ value	0.000121331 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	891	Shared Neighborhood Hits	10
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

CASP1_HUMAN
NC score	0.063762 (rank : 33)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	20	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	P29466, Q9UCN3	Gene names	CASP1, IL1BC, IL1BCE
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CJ092_HUMAN
NC score	0.062997 (rank : 34)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IYW2, Q5JSF7, Q9NTQ5	Gene names	C10orf92
Domain Architecture	No domain graphic available
Description	Protein C10orf92.

CASP4_MOUSE
NC score	0.062413 (rank : 35)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	20	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	P70343, O08735	Gene names	Casp4, Casp11, Caspl, Ich3
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].

CASP5_HUMAN
NC score	0.062090 (rank : 36)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	20	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	P51878	Gene names	CASP5, ICH3
Domain Architecture
Description	Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].

TNKS2_HUMAN
NC score	0.061887 (rank : 37)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	20	Target Neighborhood Hits	361	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

TNKS1_HUMAN
NC score	0.061850 (rank : 38)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	20	Target Neighborhood Hits	477	Shared Neighborhood Hits	4
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

ANR50_HUMAN
NC score	0.060596 (rank : 39)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	20	Target Neighborhood Hits	361	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

TRPA1_HUMAN
NC score	0.058600 (rank : 40)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	20	Target Neighborhood Hits	339	Shared Neighborhood Hits	4
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

ANR52_HUMAN
NC score	0.058145 (rank : 41)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	20	Target Neighborhood Hits	322	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANR52_MOUSE
NC score	0.057972 (rank : 42)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	20	Target Neighborhood Hits	318	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANR28_HUMAN
NC score	0.057908 (rank : 43)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	20	Target Neighborhood Hits	314	Shared Neighborhood Hits	4
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR44_HUMAN
NC score	0.057856 (rank : 44)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	20	Target Neighborhood Hits	318	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

ANFY1_HUMAN
NC score	0.057749 (rank : 45)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	20	Target Neighborhood Hits	480	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

TRPA1_MOUSE
NC score	0.057651 (rank : 46)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	20	Target Neighborhood Hits	343	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

ANFY1_MOUSE
NC score	0.057441 (rank : 47)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	20	Target Neighborhood Hits	480	Shared Neighborhood Hits	4
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANR28_MOUSE
NC score	0.057381 (rank : 48)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	20	Target Neighborhood Hits	314	Shared Neighborhood Hits	4
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR16_HUMAN
NC score	0.055812 (rank : 49)	θ value	θ > 10 (rank : 26)
Query Neighborhood Hits	20	Target Neighborhood Hits	286	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P6B7, Q9NT01	Gene names	ANKRD16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 16.

INVS_MOUSE
NC score	0.055605 (rank : 50)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	20	Target Neighborhood Hits	609	Shared Neighborhood Hits	4
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

ANKY1_HUMAN
NC score	0.055091 (rank : 51)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	20	Target Neighborhood Hits	248	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

INVS_HUMAN
NC score	0.054845 (rank : 52)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	20	Target Neighborhood Hits	455	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

ANR22_HUMAN
NC score	0.054523 (rank : 53)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	20	Target Neighborhood Hits	243	Shared Neighborhood Hits	4
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

ASB15_MOUSE
NC score	0.053671 (rank : 54)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	20	Target Neighborhood Hits	292	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VHS6	Gene names	Asb15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

ANKS6_MOUSE
NC score	0.053604 (rank : 55)	θ value	θ > 10 (rank : 24)
Query Neighborhood Hits	20	Target Neighborhood Hits	435	Shared Neighborhood Hits	4
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

CT086_HUMAN
NC score	0.053154 (rank : 56)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	20	Target Neighborhood Hits	277	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

ANR42_MOUSE
NC score	0.053116 (rank : 57)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	20	Target Neighborhood Hits	334	Shared Neighborhood Hits	4
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ASB15_HUMAN
NC score	0.052966 (rank : 58)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	20	Target Neighborhood Hits	305	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WXK1	Gene names	ASB15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

CASP4_HUMAN
NC score	0.052570 (rank : 59)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	20	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	P49662	Gene names	CASP4, ICH2
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].

ANKS6_HUMAN
NC score	0.052356 (rank : 60)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	20	Target Neighborhood Hits	411	Shared Neighborhood Hits	4
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

ASB3_MOUSE
NC score	0.051754 (rank : 61)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	20	Target Neighborhood Hits	316	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ANR29_HUMAN
NC score	0.050674 (rank : 62)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	20	Target Neighborhood Hits	294	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N6D5, Q6ZWE8, Q96LU9	Gene names	ANKRD29
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 29.

ASB14_MOUSE
NC score	0.050481 (rank : 63)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	20	Target Neighborhood Hits	293	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VHS7	Gene names	Asb14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

CASPC_MOUSE
NC score	0.050447 (rank : 64)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	O08736, Q3TT82	Gene names	Casp12
Domain Architecture
Description	Caspase-12 precursor (EC 3.4.22.-) (CASP-12).

ASB3_HUMAN
NC score	0.050442 (rank : 65)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	20	Target Neighborhood Hits	316	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y575, Q9NVZ2	Gene names	ASB3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ANR42_HUMAN
NC score	0.050028 (rank : 66)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	20	Target Neighborhood Hits	284	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

DYH11_HUMAN
NC score	0.037801 (rank : 67)	θ value	0.47712 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	234	Shared Neighborhood Hits	2
SwissProt Accessions	Q96DT5, Q9UJ82	Gene names	DNAH11
Domain Architecture
Description	Ciliary dynein heavy chain 11 (Axonemal beta dynein heavy chain 11).