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Network neighborhood for query Sequence : CRADD_HUMAN

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CRADD_HUMAN
SwissProt Accessions	P78560	Gene names	CRADD, RAIDD
Domain Architecture
Description	Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CRADD_HUMAN
θ value	3.4333e-100 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	P78560	Gene names	CRADD, RAIDD
Domain Architecture
Description	Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain).

CRADD_MOUSE
θ value	2.72669e-89 (rank : 2)	NC score	0.989122 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	11	Shared Neighborhood Hits	9
SwissProt Accessions	O88843, Q9QUN0	Gene names	Cradd, Raidd
Domain Architecture
Description	Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain).

CASP2_MOUSE
θ value	0.00665767 (rank : 3)	NC score	0.150279 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	P29594, O08737, Q3TCM0, Q8C9H7, Q8K241	Gene names	Casp2, Ich1, Nedd-2, Nedd2
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP2_HUMAN
θ value	0.00869519 (rank : 4)	NC score	0.147914 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9	Gene names	CASP2, ICH1
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

THOC1_HUMAN
θ value	0.0563607 (rank : 5)	NC score	0.138681 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q96FV9, Q15219	Gene names	THOC1, HPR1
Domain Architecture
Description	THO complex subunit 1 (Tho1) (Nuclear matrix protein p84).

ANK2_HUMAN
θ value	0.163984 (rank : 6)	NC score	0.033517 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	1615	Shared Neighborhood Hits	9
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

BCL10_HUMAN
θ value	0.163984 (rank : 7)	NC score	0.143050 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	O95999	Gene names	BCL10, CIPER, CLAP
Domain Architecture
Description	B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CED- 3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (CARD- containing molecule enhancing NF-kappa-B) (Cellular homolog of vCARMEN) (cCARMEN) (Mammalian CARD-containing adapter molecule E10) (mE10) (Cellular-E10) (c-E10) (CARD-like apoptotic protein) (hCLAP).

THOC1_MOUSE
θ value	0.21417 (rank : 8)	NC score	0.131716 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R3N6, Q8BWD5, Q8BXY3	Gene names	Thoc1
Domain Architecture
Description	THO complex subunit 1 (Tho1) (Nuclear matrix protein p84).

BCL10_MOUSE
θ value	0.365318 (rank : 9)	NC score	0.121575 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z0H7, Q3UBN4	Gene names	Bcl10, Ciper, Clap
Domain Architecture
Description	B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CED- 3/ICH-1 prodomain homologous E10-like regulator) (mCIPER) (CARD- containing molecule enhancing NF-kappa-B) (Cellular homolog of vCARMEN) (cCARMEN) (Mammalian CARD-containing adapter molecule E10) (mE10) (Cellular-E10) (c-E10) (CARD-like apoptotic protein) (mCLAP).

FADD_HUMAN
θ value	0.365318 (rank : 10)	NC score	0.100934 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	Q13158, Q14866	Gene names	FADD, MORT1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

PIDD_MOUSE
θ value	1.06291 (rank : 11)	NC score	0.045467 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	256	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ERV7	Gene names	Lrdd, Pidd
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and death domain-containing protein.

PIDD_HUMAN
θ value	3.0926 (rank : 12)	NC score	0.040036 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	271	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HB75, Q59FD1, Q59H10, Q59HC7, Q7Z4P8, Q8NC89, Q8NDL2, Q96C25, Q9NRE6	Gene names	LRDD, PIDD
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and death domain-containing protein (p53-induced protein with a death domain).

TR10B_MOUSE
θ value	5.27518 (rank : 13)	NC score	0.037854 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZM4, Q9JJL5, Q9JJL6	Gene names	Tnfrsf10b, Dr5, Killer
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10B precursor (Death receptor 5) (MK).

BIRC3_HUMAN
θ value	8.99809 (rank : 14)	NC score	0.009514 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	133	Shared Neighborhood Hits	2
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

Hits sorted by NC score

CRADD_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.4333e-100 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	P78560	Gene names	CRADD, RAIDD
Domain Architecture
Description	Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain).

CRADD_MOUSE
NC score	0.989122 (rank : 2)	θ value	2.72669e-89 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	11	Shared Neighborhood Hits	9
SwissProt Accessions	O88843, Q9QUN0	Gene names	Cradd, Raidd
Domain Architecture
Description	Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain).

CASP2_MOUSE
NC score	0.150279 (rank : 3)	θ value	0.00665767 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	P29594, O08737, Q3TCM0, Q8C9H7, Q8K241	Gene names	Casp2, Ich1, Nedd-2, Nedd2
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP2_HUMAN
NC score	0.147914 (rank : 4)	θ value	0.00869519 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9	Gene names	CASP2, ICH1
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

BCL10_HUMAN
NC score	0.143050 (rank : 5)	θ value	0.163984 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	O95999	Gene names	BCL10, CIPER, CLAP
Domain Architecture
Description	B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CED- 3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (CARD- containing molecule enhancing NF-kappa-B) (Cellular homolog of vCARMEN) (cCARMEN) (Mammalian CARD-containing adapter molecule E10) (mE10) (Cellular-E10) (c-E10) (CARD-like apoptotic protein) (hCLAP).

THOC1_HUMAN
NC score	0.138681 (rank : 6)	θ value	0.0563607 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q96FV9, Q15219	Gene names	THOC1, HPR1
Domain Architecture
Description	THO complex subunit 1 (Tho1) (Nuclear matrix protein p84).

THOC1_MOUSE
NC score	0.131716 (rank : 7)	θ value	0.21417 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R3N6, Q8BWD5, Q8BXY3	Gene names	Thoc1
Domain Architecture
Description	THO complex subunit 1 (Tho1) (Nuclear matrix protein p84).

BCL10_MOUSE
NC score	0.121575 (rank : 8)	θ value	0.365318 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z0H7, Q3UBN4	Gene names	Bcl10, Ciper, Clap
Domain Architecture
Description	B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CED- 3/ICH-1 prodomain homologous E10-like regulator) (mCIPER) (CARD- containing molecule enhancing NF-kappa-B) (Cellular homolog of vCARMEN) (cCARMEN) (Mammalian CARD-containing adapter molecule E10) (mE10) (Cellular-E10) (c-E10) (CARD-like apoptotic protein) (mCLAP).

FADD_HUMAN
NC score	0.100934 (rank : 9)	θ value	0.365318 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	Q13158, Q14866	Gene names	FADD, MORT1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

PIDD_MOUSE
NC score	0.045467 (rank : 10)	θ value	1.06291 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	256	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ERV7	Gene names	Lrdd, Pidd
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and death domain-containing protein.

PIDD_HUMAN
NC score	0.040036 (rank : 11)	θ value	3.0926 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	271	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HB75, Q59FD1, Q59H10, Q59HC7, Q7Z4P8, Q8NC89, Q8NDL2, Q96C25, Q9NRE6	Gene names	LRDD, PIDD
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and death domain-containing protein (p53-induced protein with a death domain).

TR10B_MOUSE
NC score	0.037854 (rank : 12)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZM4, Q9JJL5, Q9JJL6	Gene names	Tnfrsf10b, Dr5, Killer
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10B precursor (Death receptor 5) (MK).

ANK2_HUMAN
NC score	0.033517 (rank : 13)	θ value	0.163984 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	1615	Shared Neighborhood Hits	9
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

BIRC3_HUMAN
NC score	0.009514 (rank : 14)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	133	Shared Neighborhood Hits	2
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).