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Network neighborhood for query Sequence : AP4B1_HUMAN

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AP4B1_HUMAN
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AP4B1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_MOUSE
θ value	0 (rank : 2)	NC score	0.995354 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP2B1_HUMAN
θ value	3.69378e-78 (rank : 3)	NC score	0.885518 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	27
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_MOUSE
θ value	3.69378e-78 (rank : 4)	NC score	0.885539 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	58	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP1B1_HUMAN
θ value	8.22888e-78 (rank : 5)	NC score	0.883884 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	58	Shared Neighborhood Hits	26
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_MOUSE
θ value	1.40363e-77 (rank : 6)	NC score	0.882734 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	26
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP3B1_HUMAN
θ value	5.21438e-40 (rank : 7)	NC score	0.782778 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	283	Shared Neighborhood Hits	20
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B2_HUMAN
θ value	6.81017e-40 (rank : 8)	NC score	0.790592 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	246	Shared Neighborhood Hits	17
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP3B1_MOUSE
θ value	8.89434e-40 (rank : 9)	NC score	0.784079 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	302	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B2_MOUSE
θ value	8.89434e-40 (rank : 10)	NC score	0.789385 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	246	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

COPG2_MOUSE
θ value	1.53129e-07 (rank : 11)	NC score	0.390242 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	32	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

AP1G2_MOUSE
θ value	3.41135e-07 (rank : 12)	NC score	0.336604 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	52	Shared Neighborhood Hits	24
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

COPG2_HUMAN
θ value	5.81887e-07 (rank : 13)	NC score	0.384759 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	33	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

AP3D1_HUMAN
θ value	5.44631e-05 (rank : 14)	NC score	0.366420 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	254	Shared Neighborhood Hits	25
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

AP3D1_MOUSE
θ value	7.1131e-05 (rank : 15)	NC score	0.381478 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	144	Shared Neighborhood Hits	25
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP1G2_HUMAN
θ value	0.000602161 (rank : 16)	NC score	0.281105 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	44	Shared Neighborhood Hits	23
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

COPG_HUMAN
θ value	0.00102713 (rank : 17)	NC score	0.336641 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

COPB_HUMAN
θ value	0.00134147 (rank : 18)	NC score	0.425293 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	47	Shared Neighborhood Hits	21
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_MOUSE
θ value	0.00134147 (rank : 19)	NC score	0.424862 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	50	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

AP2A2_MOUSE
θ value	0.00509761 (rank : 20)	NC score	0.267802 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	46	Shared Neighborhood Hits	16
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP2A2_HUMAN
θ value	0.0113563 (rank : 21)	NC score	0.267250 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	39	Shared Neighborhood Hits	16
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

CDKL3_MOUSE
θ value	0.62314 (rank : 22)	NC score	0.000960 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	857	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

AP1G1_HUMAN
θ value	0.813845 (rank : 23)	NC score	0.309417 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	65	Shared Neighborhood Hits	25
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_MOUSE
θ value	0.813845 (rank : 24)	NC score	0.309792 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

FXL20_HUMAN
θ value	1.38821 (rank : 25)	NC score	0.023844 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	77	Shared Neighborhood Hits	4
SwissProt Accessions	Q96IG2	Gene names	FBXL20, FBL2
Domain Architecture
Description	F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like).

FXL20_MOUSE
θ value	1.38821 (rank : 26)	NC score	0.023889 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CZV8, Q8BZ95	Gene names	Fbxl20, Fbl2
Domain Architecture
Description	F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like).

PK3CA_HUMAN
θ value	1.38821 (rank : 27)	NC score	0.023046 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

TOP2A_MOUSE
θ value	1.38821 (rank : 28)	NC score	0.016168 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	101	Shared Neighborhood Hits	2
SwissProt Accessions	Q01320	Gene names	Top2a, Top-2, Top2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

RFIP3_HUMAN
θ value	3.0926 (rank : 29)	NC score	0.005740 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	1055	Shared Neighborhood Hits	5
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

APOH_HUMAN
θ value	4.03905 (rank : 30)	NC score	0.008766 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	P02749, Q9UCN7	Gene names	APOH, B2G1
Domain Architecture
Description	Beta-2-glycoprotein 1 precursor (Beta-2-glycoprotein I) (Apolipoprotein H) (Apo-H) (B2GPI) (Beta(2)GPI) (Activated protein C- binding protein) (APC inhibitor) (Anticardiolipin cofactor).

PLAK_MOUSE
θ value	5.27518 (rank : 31)	NC score	0.018691 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q02257, Q8CGD3	Gene names	Jup
Domain Architecture	No domain graphic available
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

DRP2_HUMAN
θ value	6.88961 (rank : 32)	NC score	0.011493 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	186	Shared Neighborhood Hits	5
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

IP3KB_HUMAN
θ value	6.88961 (rank : 33)	NC score	0.013864 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	124	Shared Neighborhood Hits	3
SwissProt Accessions	P27987, Q5VWL9, Q5VWM0, Q96BZ2, Q96JS1, Q9UH47	Gene names	ITPKB
Domain Architecture
Description	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase B) (IP3K B) (IP3 3-kinase B) (IP3K-B).

PK3CA_MOUSE
θ value	6.88961 (rank : 34)	NC score	0.020509 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PLAK_HUMAN
θ value	6.88961 (rank : 35)	NC score	0.017396 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	53	Shared Neighborhood Hits	4
SwissProt Accessions	P14923, Q9HCX9	Gene names	JUP, DP3
Domain Architecture
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

TSC1_HUMAN
θ value	6.88961 (rank : 36)	NC score	0.004481 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	765	Shared Neighborhood Hits	4
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

AP2A1_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.231357 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_MOUSE
θ value	8.99809 (rank : 38)	NC score	0.229519 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

CA065_HUMAN
θ value	8.99809 (rank : 39)	NC score	0.006416 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	469	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

RNBP6_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.010926 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	O60518, Q5T7X4, Q7Z3V2, Q96E78	Gene names	RANBP6
Domain Architecture	No domain graphic available
Description	Ran-binding protein 6 (RanBP6).

TAF5L_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.002553 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	330	Shared Neighborhood Hits	3
SwissProt Accessions	O75529, Q8IW31	Gene names	TAF5L, PAF65B
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

AP4E1_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.233926 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	57	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP4E1_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.231340 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	23
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

SPAG6_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.051954 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

Hits sorted by NC score

AP4B1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_MOUSE
NC score	0.995354 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP2B1_MOUSE
NC score	0.885539 (rank : 3)	θ value	3.69378e-78 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	58	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_HUMAN
NC score	0.885518 (rank : 4)	θ value	3.69378e-78 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	27
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP1B1_HUMAN
NC score	0.883884 (rank : 5)	θ value	8.22888e-78 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	58	Shared Neighborhood Hits	26
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_MOUSE
NC score	0.882734 (rank : 6)	θ value	1.40363e-77 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	26
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP3B2_HUMAN
NC score	0.790592 (rank : 7)	θ value	6.81017e-40 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	246	Shared Neighborhood Hits	17
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP3B2_MOUSE
NC score	0.789385 (rank : 8)	θ value	8.89434e-40 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	246	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

AP3B1_MOUSE
NC score	0.784079 (rank : 9)	θ value	8.89434e-40 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	302	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B1_HUMAN
NC score	0.782778 (rank : 10)	θ value	5.21438e-40 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	283	Shared Neighborhood Hits	20
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

COPB_HUMAN
NC score	0.425293 (rank : 11)	θ value	0.00134147 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	47	Shared Neighborhood Hits	21
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_MOUSE
NC score	0.424862 (rank : 12)	θ value	0.00134147 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	50	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPG2_MOUSE
NC score	0.390242 (rank : 13)	θ value	1.53129e-07 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	32	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG2_HUMAN
NC score	0.384759 (rank : 14)	θ value	5.81887e-07 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	33	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

AP3D1_MOUSE
NC score	0.381478 (rank : 15)	θ value	7.1131e-05 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	144	Shared Neighborhood Hits	25
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP3D1_HUMAN
NC score	0.366420 (rank : 16)	θ value	5.44631e-05 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	254	Shared Neighborhood Hits	25
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

COPG_HUMAN
NC score	0.336641 (rank : 17)	θ value	0.00102713 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

AP1G2_MOUSE
NC score	0.336604 (rank : 18)	θ value	3.41135e-07 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	52	Shared Neighborhood Hits	24
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP1G1_MOUSE
NC score	0.309792 (rank : 19)	θ value	0.813845 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_HUMAN
NC score	0.309417 (rank : 20)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	65	Shared Neighborhood Hits	25
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G2_HUMAN
NC score	0.281105 (rank : 21)	θ value	0.000602161 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	44	Shared Neighborhood Hits	23
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP2A2_MOUSE
NC score	0.267802 (rank : 22)	θ value	0.00509761 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	46	Shared Neighborhood Hits	16
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP2A2_HUMAN
NC score	0.267250 (rank : 23)	θ value	0.0113563 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	39	Shared Neighborhood Hits	16
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP4E1_HUMAN
NC score	0.233926 (rank : 24)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	57	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP2A1_HUMAN
NC score	0.231357 (rank : 25)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP4E1_MOUSE
NC score	0.231340 (rank : 26)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	23
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP2A1_MOUSE
NC score	0.229519 (rank : 27)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

SPAG6_HUMAN
NC score	0.051954 (rank : 28)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

FXL20_MOUSE
NC score	0.023889 (rank : 29)	θ value	1.38821 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CZV8, Q8BZ95	Gene names	Fbxl20, Fbl2
Domain Architecture
Description	F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like).

FXL20_HUMAN
NC score	0.023844 (rank : 30)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	77	Shared Neighborhood Hits	4
SwissProt Accessions	Q96IG2	Gene names	FBXL20, FBL2
Domain Architecture
Description	F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like).

PK3CA_HUMAN
NC score	0.023046 (rank : 31)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
NC score	0.020509 (rank : 32)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PLAK_MOUSE
NC score	0.018691 (rank : 33)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q02257, Q8CGD3	Gene names	Jup
Domain Architecture	No domain graphic available
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

PLAK_HUMAN
NC score	0.017396 (rank : 34)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	53	Shared Neighborhood Hits	4
SwissProt Accessions	P14923, Q9HCX9	Gene names	JUP, DP3
Domain Architecture
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

TOP2A_MOUSE
NC score	0.016168 (rank : 35)	θ value	1.38821 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	101	Shared Neighborhood Hits	2
SwissProt Accessions	Q01320	Gene names	Top2a, Top-2, Top2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

IP3KB_HUMAN
NC score	0.013864 (rank : 36)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	124	Shared Neighborhood Hits	3
SwissProt Accessions	P27987, Q5VWL9, Q5VWM0, Q96BZ2, Q96JS1, Q9UH47	Gene names	ITPKB
Domain Architecture
Description	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase B) (IP3K B) (IP3 3-kinase B) (IP3K-B).

DRP2_HUMAN
NC score	0.011493 (rank : 37)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	186	Shared Neighborhood Hits	5
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

RNBP6_HUMAN
NC score	0.010926 (rank : 38)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	O60518, Q5T7X4, Q7Z3V2, Q96E78	Gene names	RANBP6
Domain Architecture	No domain graphic available
Description	Ran-binding protein 6 (RanBP6).

APOH_HUMAN
NC score	0.008766 (rank : 39)	θ value	4.03905 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	P02749, Q9UCN7	Gene names	APOH, B2G1
Domain Architecture
Description	Beta-2-glycoprotein 1 precursor (Beta-2-glycoprotein I) (Apolipoprotein H) (Apo-H) (B2GPI) (Beta(2)GPI) (Activated protein C- binding protein) (APC inhibitor) (Anticardiolipin cofactor).

CA065_HUMAN
NC score	0.006416 (rank : 40)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	469	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

RFIP3_HUMAN
NC score	0.005740 (rank : 41)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	1055	Shared Neighborhood Hits	5
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

TSC1_HUMAN
NC score	0.004481 (rank : 42)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	765	Shared Neighborhood Hits	4
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

TAF5L_HUMAN
NC score	0.002553 (rank : 43)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	330	Shared Neighborhood Hits	3
SwissProt Accessions	O75529, Q8IW31	Gene names	TAF5L, PAF65B
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

CDKL3_MOUSE
NC score	0.000960 (rank : 44)	θ value	0.62314 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	857	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).