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Network neighborhood for query Sequence : RASA2_HUMAN

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RASA2_HUMAN
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RASA2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	157
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA2_MOUSE
θ value	0 (rank : 2)	NC score	0.994915 (rank : 2)
Query Neighborhood Hits	157	Target Neighborhood Hits	159	Shared Neighborhood Hits	138
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA3_HUMAN
θ value	0 (rank : 3)	NC score	0.972038 (rank : 4)
Query Neighborhood Hits	157	Target Neighborhood Hits	166	Shared Neighborhood Hits	127
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASA3_MOUSE
θ value	0 (rank : 4)	NC score	0.974617 (rank : 3)
Query Neighborhood Hits	157	Target Neighborhood Hits	144	Shared Neighborhood Hits	119
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RASL2_HUMAN
θ value	6.93392e-93 (rank : 5)	NC score	0.846629 (rank : 6)
Query Neighborhood Hits	157	Target Neighborhood Hits	161	Shared Neighborhood Hits	102
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RASL1_MOUSE
θ value	1.31072e-83 (rank : 6)	NC score	0.855058 (rank : 5)
Query Neighborhood Hits	157	Target Neighborhood Hits	148	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_HUMAN
θ value	8.22888e-78 (rank : 7)	NC score	0.841474 (rank : 7)
Query Neighborhood Hits	157	Target Neighborhood Hits	142	Shared Neighborhood Hits	98
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASA1_HUMAN
θ value	1.02001e-27 (rank : 8)	NC score	0.557159 (rank : 11)
Query Neighborhood Hits	157	Target Neighborhood Hits	258	Shared Neighborhood Hits	65
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

DAB2P_MOUSE
θ value	2.12685e-25 (rank : 9)	NC score	0.593806 (rank : 9)
Query Neighborhood Hits	157	Target Neighborhood Hits	284	Shared Neighborhood Hits	28
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

DAB2P_HUMAN
θ value	2.77775e-25 (rank : 10)	NC score	0.593884 (rank : 8)
Query Neighborhood Hits	157	Target Neighborhood Hits	303	Shared Neighborhood Hits	30
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

SYGP1_HUMAN
θ value	1.05554e-24 (rank : 11)	NC score	0.536514 (rank : 12)
Query Neighborhood Hits	157	Target Neighborhood Hits	589	Shared Neighborhood Hits	27
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

NGAP_HUMAN
θ value	1.80048e-24 (rank : 12)	NC score	0.558478 (rank : 10)
Query Neighborhood Hits	157	Target Neighborhood Hits	517	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

NF1_MOUSE
θ value	1.92812e-18 (rank : 13)	NC score	0.498996 (rank : 13)
Query Neighborhood Hits	157	Target Neighborhood Hits	62	Shared Neighborhood Hits	18
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

NF1_HUMAN
θ value	2.7842e-17 (rank : 14)	NC score	0.495659 (rank : 14)
Query Neighborhood Hits	157	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

BMX_HUMAN
θ value	9.26847e-13 (rank : 15)	NC score	0.125775 (rank : 116)
Query Neighborhood Hits	157	Target Neighborhood Hits	942	Shared Neighborhood Hits	45
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

ITK_MOUSE
θ value	1.2105e-12 (rank : 16)	NC score	0.116634 (rank : 121)
Query Neighborhood Hits	157	Target Neighborhood Hits	985	Shared Neighborhood Hits	30
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

BMX_MOUSE
θ value	1.58096e-12 (rank : 17)	NC score	0.123885 (rank : 117)
Query Neighborhood Hits	157	Target Neighborhood Hits	912	Shared Neighborhood Hits	44
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BTK_HUMAN
θ value	1.74796e-11 (rank : 18)	NC score	0.107143 (rank : 129)
Query Neighborhood Hits	157	Target Neighborhood Hits	1026	Shared Neighborhood Hits	32
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	1.74796e-11 (rank : 19)	NC score	0.107744 (rank : 128)
Query Neighborhood Hits	157	Target Neighborhood Hits	1017	Shared Neighborhood Hits	32
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

ITK_HUMAN
θ value	2.98157e-11 (rank : 20)	NC score	0.113865 (rank : 122)
Query Neighborhood Hits	157	Target Neighborhood Hits	1016	Shared Neighborhood Hits	37
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

SYTL1_HUMAN
θ value	5.08577e-11 (rank : 21)	NC score	0.452636 (rank : 17)
Query Neighborhood Hits	157	Target Neighborhood Hits	227	Shared Neighborhood Hits	79
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL1_MOUSE
θ value	4.30538e-10 (rank : 22)	NC score	0.438640 (rank : 29)
Query Neighborhood Hits	157	Target Neighborhood Hits	314	Shared Neighborhood Hits	75
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL4_MOUSE
θ value	2.13673e-09 (rank : 23)	NC score	0.414657 (rank : 41)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	76
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

TEC_HUMAN
θ value	2.13673e-09 (rank : 24)	NC score	0.111907 (rank : 124)
Query Neighborhood Hits	157	Target Neighborhood Hits	1006	Shared Neighborhood Hits	44
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SYT3_HUMAN
θ value	8.11959e-09 (rank : 25)	NC score	0.457276 (rank : 16)
Query Neighborhood Hits	157	Target Neighborhood Hits	145	Shared Neighborhood Hits	83
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_MOUSE
θ value	1.80886e-08 (rank : 26)	NC score	0.458124 (rank : 15)
Query Neighborhood Hits	157	Target Neighborhood Hits	147	Shared Neighborhood Hits	83
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT9_HUMAN
θ value	5.26297e-08 (rank : 27)	NC score	0.446302 (rank : 20)
Query Neighborhood Hits	157	Target Neighborhood Hits	144	Shared Neighborhood Hits	84
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYTL4_HUMAN
θ value	6.87365e-08 (rank : 28)	NC score	0.418309 (rank : 40)
Query Neighborhood Hits	157	Target Neighborhood Hits	138	Shared Neighborhood Hits	79
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYT9_MOUSE
θ value	1.99992e-07 (rank : 29)	NC score	0.441172 (rank : 22)
Query Neighborhood Hits	157	Target Neighborhood Hits	148	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

TEC_MOUSE
θ value	1.99992e-07 (rank : 30)	NC score	0.106936 (rank : 130)
Query Neighborhood Hits	157	Target Neighborhood Hits	1006	Shared Neighborhood Hits	44
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SYTL5_HUMAN
θ value	3.41135e-07 (rank : 31)	NC score	0.400866 (rank : 46)
Query Neighborhood Hits	157	Target Neighborhood Hits	237	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYT11_MOUSE
θ value	7.59969e-07 (rank : 32)	NC score	0.428312 (rank : 35)
Query Neighborhood Hits	157	Target Neighborhood Hits	116	Shared Neighborhood Hits	81
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_HUMAN
θ value	9.92553e-07 (rank : 33)	NC score	0.427541 (rank : 36)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	81
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYTL2_MOUSE
θ value	1.29631e-06 (rank : 34)	NC score	0.438482 (rank : 30)
Query Neighborhood Hits	157	Target Neighborhood Hits	253	Shared Neighborhood Hits	82
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

MYO10_HUMAN
θ value	1.69304e-06 (rank : 35)	NC score	0.077598 (rank : 160)
Query Neighborhood Hits	157	Target Neighborhood Hits	920	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

SYT2_MOUSE
θ value	2.21117e-06 (rank : 36)	NC score	0.440967 (rank : 23)
Query Neighborhood Hits	157	Target Neighborhood Hits	143	Shared Neighborhood Hits	83
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT4_MOUSE
θ value	2.21117e-06 (rank : 37)	NC score	0.436348 (rank : 31)
Query Neighborhood Hits	157	Target Neighborhood Hits	123	Shared Neighborhood Hits	80
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

NED4L_HUMAN
θ value	2.88788e-06 (rank : 38)	NC score	0.229602 (rank : 74)
Query Neighborhood Hits	157	Target Neighborhood Hits	238	Shared Neighborhood Hits	84
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	2.88788e-06 (rank : 39)	NC score	0.227434 (rank : 75)
Query Neighborhood Hits	157	Target Neighborhood Hits	231	Shared Neighborhood Hits	83
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

SYT2_HUMAN
θ value	2.88788e-06 (rank : 40)	NC score	0.440616 (rank : 24)
Query Neighborhood Hits	157	Target Neighborhood Hits	142	Shared Neighborhood Hits	83
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT4_HUMAN
θ value	2.88788e-06 (rank : 41)	NC score	0.433033 (rank : 32)
Query Neighborhood Hits	157	Target Neighborhood Hits	121	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYTL5_MOUSE
θ value	6.43352e-06 (rank : 42)	NC score	0.395715 (rank : 48)
Query Neighborhood Hits	157	Target Neighborhood Hits	154	Shared Neighborhood Hits	79
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL2_HUMAN
θ value	8.40245e-06 (rank : 43)	NC score	0.439479 (rank : 26)
Query Neighborhood Hits	157	Target Neighborhood Hits	248	Shared Neighborhood Hits	85
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL3_MOUSE
θ value	8.40245e-06 (rank : 44)	NC score	0.387945 (rank : 53)
Query Neighborhood Hits	157	Target Neighborhood Hits	110	Shared Neighborhood Hits	69
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYT7_HUMAN
θ value	1.43324e-05 (rank : 45)	NC score	0.445443 (rank : 21)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	86
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT1_HUMAN
θ value	2.44474e-05 (rank : 46)	NC score	0.438897 (rank : 27)
Query Neighborhood Hits	157	Target Neighborhood Hits	150	Shared Neighborhood Hits	84
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	2.44474e-05 (rank : 47)	NC score	0.438886 (rank : 28)
Query Neighborhood Hits	157	Target Neighborhood Hits	150	Shared Neighborhood Hits	84
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

PKHA1_HUMAN
θ value	3.19293e-05 (rank : 48)	NC score	0.269888 (rank : 65)
Query Neighborhood Hits	157	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	3.19293e-05 (rank : 49)	NC score	0.272105 (rank : 64)
Query Neighborhood Hits	157	Target Neighborhood Hits	120	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_MOUSE
θ value	4.1701e-05 (rank : 50)	NC score	0.243798 (rank : 72)
Query Neighborhood Hits	157	Target Neighborhood Hits	116	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

SYT5_HUMAN
θ value	4.1701e-05 (rank : 51)	NC score	0.448153 (rank : 19)
Query Neighborhood Hits	157	Target Neighborhood Hits	138	Shared Neighborhood Hits	83
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT12_HUMAN
θ value	7.1131e-05 (rank : 52)	NC score	0.394088 (rank : 49)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT7_MOUSE
θ value	7.1131e-05 (rank : 53)	NC score	0.439686 (rank : 25)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	86
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT12_MOUSE
θ value	9.29e-05 (rank : 54)	NC score	0.395909 (rank : 47)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	73
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT5_MOUSE
θ value	0.000121331 (rank : 55)	NC score	0.448945 (rank : 18)
Query Neighborhood Hits	157	Target Neighborhood Hits	140	Shared Neighborhood Hits	83
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT6_HUMAN
θ value	0.000158464 (rank : 56)	NC score	0.430769 (rank : 33)
Query Neighborhood Hits	157	Target Neighborhood Hits	138	Shared Neighborhood Hits	82
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT6_MOUSE
θ value	0.000158464 (rank : 57)	NC score	0.430628 (rank : 34)
Query Neighborhood Hits	157	Target Neighborhood Hits	132	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

FA62A_MOUSE
θ value	0.00020696 (rank : 58)	NC score	0.402044 (rank : 45)
Query Neighborhood Hits	157	Target Neighborhood Hits	155	Shared Neighborhood Hits	88
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

KPCA_HUMAN
θ value	0.00020696 (rank : 59)	NC score	0.140936 (rank : 107)
Query Neighborhood Hits	157	Target Neighborhood Hits	1070	Shared Neighborhood Hits	99
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

SYT10_HUMAN
θ value	0.00020696 (rank : 60)	NC score	0.426820 (rank : 38)
Query Neighborhood Hits	157	Target Neighborhood Hits	134	Shared Neighborhood Hits	83
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT10_MOUSE
θ value	0.00020696 (rank : 61)	NC score	0.427412 (rank : 37)
Query Neighborhood Hits	157	Target Neighborhood Hits	133	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT8_MOUSE
θ value	0.00020696 (rank : 62)	NC score	0.386188 (rank : 54)
Query Neighborhood Hits	157	Target Neighborhood Hits	94	Shared Neighborhood Hits	69
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

RFIP2_HUMAN
θ value	0.000461057 (rank : 63)	NC score	0.317817 (rank : 58)
Query Neighborhood Hits	157	Target Neighborhood Hits	97	Shared Neighborhood Hits	65
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

NEDD4_MOUSE
θ value	0.000602161 (rank : 64)	NC score	0.199617 (rank : 91)
Query Neighborhood Hits	157	Target Neighborhood Hits	212	Shared Neighborhood Hits	78
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

PKHA2_HUMAN
θ value	0.000786445 (rank : 65)	NC score	0.223190 (rank : 80)
Query Neighborhood Hits	157	Target Neighborhood Hits	119	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

RGS3_HUMAN
θ value	0.000786445 (rank : 66)	NC score	0.121557 (rank : 119)
Query Neighborhood Hits	157	Target Neighborhood Hits	1375	Shared Neighborhood Hits	72
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

DOC2A_MOUSE
θ value	0.00102713 (rank : 67)	NC score	0.419504 (rank : 39)
Query Neighborhood Hits	157	Target Neighborhood Hits	140	Shared Neighborhood Hits	82
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

KPCA_MOUSE
θ value	0.00102713 (rank : 68)	NC score	0.137487 (rank : 110)
Query Neighborhood Hits	157	Target Neighborhood Hits	1067	Shared Neighborhood Hits	99
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

P3C2B_HUMAN
θ value	0.00102713 (rank : 69)	NC score	0.223684 (rank : 79)
Query Neighborhood Hits	157	Target Neighborhood Hits	148	Shared Neighborhood Hits	73
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

KPCB_HUMAN
θ value	0.00134147 (rank : 70)	NC score	0.141029 (rank : 106)
Query Neighborhood Hits	157	Target Neighborhood Hits	1121	Shared Neighborhood Hits	98
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

DOC2B_MOUSE
θ value	0.00228821 (rank : 71)	NC score	0.412858 (rank : 43)
Query Neighborhood Hits	157	Target Neighborhood Hits	169	Shared Neighborhood Hits	86
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

PKHA6_MOUSE
θ value	0.00228821 (rank : 72)	NC score	0.129055 (rank : 113)
Query Neighborhood Hits	157	Target Neighborhood Hits	591	Shared Neighborhood Hits	41
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

DAPP1_MOUSE
θ value	0.00298849 (rank : 73)	NC score	0.200994 (rank : 90)
Query Neighborhood Hits	157	Target Neighborhood Hits	225	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

FGD5_HUMAN
θ value	0.00298849 (rank : 74)	NC score	0.074685 (rank : 166)
Query Neighborhood Hits	157	Target Neighborhood Hits	235	Shared Neighborhood Hits	22
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

KPCB_MOUSE
θ value	0.00298849 (rank : 75)	NC score	0.141294 (rank : 105)
Query Neighborhood Hits	157	Target Neighborhood Hits	1117	Shared Neighborhood Hits	98
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

DAPP1_HUMAN
θ value	0.00390308 (rank : 76)	NC score	0.202123 (rank : 89)
Query Neighborhood Hits	157	Target Neighborhood Hits	227	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DOC2A_HUMAN
θ value	0.00390308 (rank : 77)	NC score	0.414260 (rank : 42)
Query Neighborhood Hits	157	Target Neighborhood Hits	144	Shared Neighborhood Hits	84
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2B_HUMAN
θ value	0.00390308 (rank : 78)	NC score	0.412241 (rank : 44)
Query Neighborhood Hits	157	Target Neighborhood Hits	150	Shared Neighborhood Hits	86
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

PCLO_HUMAN
θ value	0.00390308 (rank : 79)	NC score	0.247565 (rank : 70)
Query Neighborhood Hits	157	Target Neighborhood Hits	2046	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SYT15_MOUSE
θ value	0.00509761 (rank : 80)	NC score	0.349588 (rank : 57)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	74
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

KPCG_MOUSE
θ value	0.00665767 (rank : 81)	NC score	0.142904 (rank : 100)
Query Neighborhood Hits	157	Target Neighborhood Hits	1123	Shared Neighborhood Hits	99
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

MYOF_HUMAN
θ value	0.00665767 (rank : 82)	NC score	0.231428 (rank : 73)
Query Neighborhood Hits	157	Target Neighborhood Hits	147	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

NEDD4_HUMAN
θ value	0.00665767 (rank : 83)	NC score	0.202959 (rank : 88)
Query Neighborhood Hits	157	Target Neighborhood Hits	214	Shared Neighborhood Hits	78
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

PKHA6_HUMAN
θ value	0.00665767 (rank : 84)	NC score	0.131631 (rank : 111)
Query Neighborhood Hits	157	Target Neighborhood Hits	556	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

RP3A_MOUSE
θ value	0.00665767 (rank : 85)	NC score	0.388060 (rank : 52)
Query Neighborhood Hits	157	Target Neighborhood Hits	510	Shared Neighborhood Hits	86
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT15_HUMAN
θ value	0.00665767 (rank : 86)	NC score	0.369010 (rank : 56)
Query Neighborhood Hits	157	Target Neighborhood Hits	112	Shared Neighborhood Hits	75
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

KPCL_MOUSE
θ value	0.00869519 (rank : 87)	NC score	0.060209 (rank : 183)
Query Neighborhood Hits	157	Target Neighborhood Hits	891	Shared Neighborhood Hits	42
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

UN13B_MOUSE
θ value	0.00869519 (rank : 88)	NC score	0.256462 (rank : 66)
Query Neighborhood Hits	157	Target Neighborhood Hits	210	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

CEND1_HUMAN
θ value	0.0113563 (rank : 89)	NC score	0.085957 (rank : 147)
Query Neighborhood Hits	157	Target Neighborhood Hits	284	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

FA62A_HUMAN
θ value	0.0113563 (rank : 90)	NC score	0.381297 (rank : 55)
Query Neighborhood Hits	157	Target Neighborhood Hits	168	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FGD5_MOUSE
θ value	0.0113563 (rank : 91)	NC score	0.062349 (rank : 179)
Query Neighborhood Hits	157	Target Neighborhood Hits	170	Shared Neighborhood Hits	16
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

KPCG_HUMAN
θ value	0.0113563 (rank : 92)	NC score	0.142364 (rank : 102)
Query Neighborhood Hits	157	Target Neighborhood Hits	1126	Shared Neighborhood Hits	100
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

UN13B_HUMAN
θ value	0.0148317 (rank : 93)	NC score	0.252035 (rank : 67)
Query Neighborhood Hits	157	Target Neighborhood Hits	217	Shared Neighborhood Hits	77
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

PA24D_MOUSE
θ value	0.0193708 (rank : 94)	NC score	0.193586 (rank : 92)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	68
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

RP3A_HUMAN
θ value	0.0193708 (rank : 95)	NC score	0.389424 (rank : 51)
Query Neighborhood Hits	157	Target Neighborhood Hits	305	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

UN13A_HUMAN
θ value	0.0252991 (rank : 96)	NC score	0.251284 (rank : 68)
Query Neighborhood Hits	157	Target Neighborhood Hits	285	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

CENB1_HUMAN
θ value	0.0330416 (rank : 97)	NC score	0.069581 (rank : 171)
Query Neighborhood Hits	157	Target Neighborhood Hits	383	Shared Neighborhood Hits	34
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

GAB2_MOUSE
θ value	0.0330416 (rank : 98)	NC score	0.110295 (rank : 125)
Query Neighborhood Hits	157	Target Neighborhood Hits	220	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

DOC2G_MOUSE
θ value	0.0431538 (rank : 99)	NC score	0.390152 (rank : 50)
Query Neighborhood Hits	157	Target Neighborhood Hits	125	Shared Neighborhood Hits	81
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

GRB14_HUMAN
θ value	0.0431538 (rank : 100)	NC score	0.059479 (rank : 187)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	20
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

KPCE_MOUSE
θ value	0.0431538 (rank : 101)	NC score	0.056829 (rank : 197)
Query Neighborhood Hits	157	Target Neighborhood Hits	906	Shared Neighborhood Hits	40
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCL_HUMAN
θ value	0.0431538 (rank : 102)	NC score	0.054521 (rank : 207)
Query Neighborhood Hits	157	Target Neighborhood Hits	887	Shared Neighborhood Hits	38
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

DGKH_HUMAN
θ value	0.0563607 (rank : 103)	NC score	0.126669 (rank : 115)
Query Neighborhood Hits	157	Target Neighborhood Hits	255	Shared Neighborhood Hits	50
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

BAIP3_MOUSE
θ value	0.0736092 (rank : 104)	NC score	0.274496 (rank : 61)
Query Neighborhood Hits	157	Target Neighborhood Hits	112	Shared Neighborhood Hits	71
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

PCLO_MOUSE
θ value	0.0736092 (rank : 105)	NC score	0.226144 (rank : 77)
Query Neighborhood Hits	157	Target Neighborhood Hits	2275	Shared Neighborhood Hits	89
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SWP70_HUMAN
θ value	0.0736092 (rank : 106)	NC score	0.080647 (rank : 156)
Query Neighborhood Hits	157	Target Neighborhood Hits	973	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CENB5_HUMAN
θ value	0.0961366 (rank : 107)	NC score	0.074230 (rank : 167)
Query Neighborhood Hits	157	Target Neighborhood Hits	395	Shared Neighborhood Hits	35
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

KPCE_HUMAN
θ value	0.0961366 (rank : 108)	NC score	0.056011 (rank : 203)
Query Neighborhood Hits	157	Target Neighborhood Hits	906	Shared Neighborhood Hits	40
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

SWP70_MOUSE
θ value	0.0961366 (rank : 109)	NC score	0.076724 (rank : 163)
Query Neighborhood Hits	157	Target Neighborhood Hits	1097	Shared Neighborhood Hits	45
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

GAB2_HUMAN
θ value	0.125558 (rank : 110)	NC score	0.112066 (rank : 123)
Query Neighborhood Hits	157	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

IQGA2_HUMAN
θ value	0.125558 (rank : 111)	NC score	0.159823 (rank : 97)
Query Neighborhood Hits	157	Target Neighborhood Hits	200	Shared Neighborhood Hits	17
SwissProt Accessions	Q13576	Gene names	IQGAP2
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP2.

DGKD_HUMAN
θ value	0.163984 (rank : 112)	NC score	0.109860 (rank : 126)
Query Neighborhood Hits	157	Target Neighborhood Hits	231	Shared Neighborhood Hits	37
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

RFIP1_HUMAN
θ value	0.163984 (rank : 113)	NC score	0.141928 (rank : 104)
Query Neighborhood Hits	157	Target Neighborhood Hits	236	Shared Neighborhood Hits	41
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

CEND1_MOUSE
θ value	0.21417 (rank : 114)	NC score	0.071364 (rank : 169)
Query Neighborhood Hits	157	Target Neighborhood Hits	260	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

BAIP3_HUMAN
θ value	0.279714 (rank : 115)	NC score	0.278721 (rank : 59)
Query Neighborhood Hits	157	Target Neighborhood Hits	108	Shared Neighborhood Hits	72
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

OTOF_HUMAN
θ value	0.279714 (rank : 116)	NC score	0.210622 (rank : 84)
Query Neighborhood Hits	157	Target Neighborhood Hits	168	Shared Neighborhood Hits	68
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

OTOF_MOUSE
θ value	0.279714 (rank : 117)	NC score	0.208634 (rank : 86)
Query Neighborhood Hits	157	Target Neighborhood Hits	196	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

CENA1_HUMAN
θ value	0.365318 (rank : 118)	NC score	0.053455 (rank : 208)
Query Neighborhood Hits	157	Target Neighborhood Hits	87	Shared Neighborhood Hits	27
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

PLXA3_HUMAN
θ value	0.365318 (rank : 119)	NC score	0.042703 (rank : 222)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	10
SwissProt Accessions	P51805	Gene names	PLXNA3, PLXN4, SEX
Domain Architecture
Description	Plexin-A3 precursor (Plexin-4) (Semaphorin receptor SEX).

PLXA4_HUMAN
θ value	0.365318 (rank : 120)	NC score	0.034859 (rank : 225)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HCM2, Q6UWC6, Q6ZW89, Q8N969, Q8ND00, Q8NEN3, Q9NTD4	Gene names	PLXNA4, KIAA1550, PLXNA4A, PLXNA4B
Domain Architecture	No domain graphic available
Description	Plexin-A4 precursor.

PLXA4_MOUSE
θ value	0.365318 (rank : 121)	NC score	0.034898 (rank : 224)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	10
SwissProt Accessions	Q80UG2, Q5DTW8, Q8BKK9	Gene names	Plxna4, Kiaa1550
Domain Architecture	No domain graphic available
Description	Plexin-A4 precursor.

CENB2_HUMAN
θ value	0.47712 (rank : 122)	NC score	0.080667 (rank : 155)
Query Neighborhood Hits	157	Target Neighborhood Hits	425	Shared Neighborhood Hits	36
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

IMA7_HUMAN
θ value	0.47712 (rank : 123)	NC score	0.019712 (rank : 229)
Query Neighborhood Hits	157	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	O60684	Gene names	KPNA6, IPOA7
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6).

IMA7_MOUSE
θ value	0.47712 (rank : 124)	NC score	0.019695 (rank : 230)
Query Neighborhood Hits	157	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	O35345, Q9CVP9	Gene names	Kpna6, Kpna5
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6 subunit) (Importin alpha S2).

CYH1_HUMAN
θ value	1.06291 (rank : 125)	NC score	0.087973 (rank : 145)
Query Neighborhood Hits	157	Target Neighborhood Hits	184	Shared Neighborhood Hits	43
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	1.06291 (rank : 126)	NC score	0.085087 (rank : 149)
Query Neighborhood Hits	157	Target Neighborhood Hits	176	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

NALP6_MOUSE
θ value	1.06291 (rank : 127)	NC score	0.009415 (rank : 234)
Query Neighborhood Hits	157	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

TEX15_HUMAN
θ value	1.06291 (rank : 128)	NC score	0.034248 (rank : 226)
Query Neighborhood Hits	157	Target Neighborhood Hits	174	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXT5	Gene names	TEX15
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 15 protein.

GAB1_HUMAN
θ value	1.38821 (rank : 129)	NC score	0.092885 (rank : 142)
Query Neighborhood Hits	157	Target Neighborhood Hits	279	Shared Neighborhood Hits	34
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

P3C2A_HUMAN
θ value	1.38821 (rank : 130)	NC score	0.183211 (rank : 93)
Query Neighborhood Hits	157	Target Neighborhood Hits	188	Shared Neighborhood Hits	68
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

IQGA1_MOUSE
θ value	1.81305 (rank : 131)	NC score	0.139654 (rank : 109)
Query Neighborhood Hits	157	Target Neighborhood Hits	219	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JKF1	Gene names	Iqgap1
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1.

P3C2A_MOUSE
θ value	1.81305 (rank : 132)	NC score	0.182493 (rank : 94)
Query Neighborhood Hits	157	Target Neighborhood Hits	181	Shared Neighborhood Hits	68
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

GAB1_MOUSE
θ value	3.0926 (rank : 133)	NC score	0.085218 (rank : 148)
Query Neighborhood Hits	157	Target Neighborhood Hits	233	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

PKHA5_HUMAN
θ value	3.0926 (rank : 134)	NC score	0.097643 (rank : 135)
Query Neighborhood Hits	157	Target Neighborhood Hits	455	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RIMS4_HUMAN
θ value	3.0926 (rank : 135)	NC score	0.170450 (rank : 96)
Query Neighborhood Hits	157	Target Neighborhood Hits	76	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
θ value	3.0926 (rank : 136)	NC score	0.171801 (rank : 95)
Query Neighborhood Hits	157	Target Neighborhood Hits	76	Shared Neighborhood Hits	65
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

STK40_HUMAN
θ value	3.0926 (rank : 137)	NC score	0.018935 (rank : 231)
Query Neighborhood Hits	157	Target Neighborhood Hits	751	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

CYH3_HUMAN
θ value	4.03905 (rank : 138)	NC score	0.077355 (rank : 161)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	38
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

FBX46_HUMAN
θ value	4.03905 (rank : 139)	NC score	0.032294 (rank : 227)
Query Neighborhood Hits	157	Target Neighborhood Hits	68	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PJ61	Gene names	FBXO46, FBX46, FBXO34L
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

FBX46_MOUSE
θ value	4.03905 (rank : 140)	NC score	0.030978 (rank : 228)
Query Neighborhood Hits	157	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BG80	Gene names	Fbxo46, Fbx46, Fbxo34l
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

IMA2_HUMAN
θ value	4.03905 (rank : 141)	NC score	0.015029 (rank : 233)
Query Neighborhood Hits	157	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	P52292, Q9BRU5	Gene names	KPNA2, RCH1, SRP1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1).

STK40_MOUSE
θ value	4.03905 (rank : 142)	NC score	0.017753 (rank : 232)
Query Neighborhood Hits	157	Target Neighborhood Hits	751	Shared Neighborhood Hits	17
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

CENA2_HUMAN
θ value	5.27518 (rank : 143)	NC score	0.056038 (rank : 202)
Query Neighborhood Hits	157	Target Neighborhood Hits	83	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

LY9_HUMAN
θ value	5.27518 (rank : 144)	NC score	0.006952 (rank : 236)
Query Neighborhood Hits	157	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBG7, Q14775, Q5VYI3, Q9H4N5, Q9NQ24	Gene names	LY9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9) (CD229 antigen).

SMO_MOUSE
θ value	5.27518 (rank : 145)	NC score	0.009220 (rank : 235)
Query Neighborhood Hits	157	Target Neighborhood Hits	61	Shared Neighborhood Hits	4
SwissProt Accessions	P56726	Gene names	Smo, Smoh
Domain Architecture	No domain graphic available
Description	Smoothened homolog precursor (SMO).

CPNE3_MOUSE
θ value	6.88961 (rank : 146)	NC score	0.106434 (rank : 131)
Query Neighborhood Hits	157	Target Neighborhood Hits	90	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE7_HUMAN
θ value	6.88961 (rank : 147)	NC score	0.084752 (rank : 150)
Query Neighborhood Hits	157	Target Neighborhood Hits	92	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

DUS16_HUMAN
θ value	6.88961 (rank : 148)	NC score	0.002887 (rank : 239)
Query Neighborhood Hits	157	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BY84, Q9C0G3	Gene names	DUSP16, KIAA1700, MKP7
Domain Architecture
Description	Dual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).

DYSF_MOUSE
θ value	6.88961 (rank : 149)	NC score	0.210202 (rank : 85)
Query Neighborhood Hits	157	Target Neighborhood Hits	162	Shared Neighborhood Hits	82
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

IQGA1_HUMAN
θ value	6.88961 (rank : 150)	NC score	0.129389 (rank : 112)
Query Neighborhood Hits	157	Target Neighborhood Hits	250	Shared Neighborhood Hits	16
SwissProt Accessions	P46940	Gene names	IQGAP1, KIAA0051
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1 (p195).

IQGA3_HUMAN
θ value	6.88961 (rank : 151)	NC score	0.123587 (rank : 118)
Query Neighborhood Hits	157	Target Neighborhood Hits	125	Shared Neighborhood Hits	17
SwissProt Accessions	Q86VI3	Gene names	IQGAP3
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP3.

NHERF_MOUSE
θ value	6.88961 (rank : 152)	NC score	0.003085 (rank : 238)
Query Neighborhood Hits	157	Target Neighborhood Hits	195	Shared Neighborhood Hits	3
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

P3C2G_MOUSE
θ value	6.88961 (rank : 153)	NC score	0.061109 (rank : 180)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	56
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

SMO_HUMAN
θ value	6.88961 (rank : 154)	NC score	0.006576 (rank : 237)
Query Neighborhood Hits	157	Target Neighborhood Hits	61	Shared Neighborhood Hits	3
SwissProt Accessions	Q99835	Gene names	SMO, SMOH
Domain Architecture
Description	Smoothened homolog precursor (SMO) (Gx protein).

CNKR1_HUMAN
θ value	8.99809 (rank : 155)	NC score	0.040883 (rank : 223)
Query Neighborhood Hits	157	Target Neighborhood Hits	154	Shared Neighborhood Hits	29
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CYH2_HUMAN
θ value	8.99809 (rank : 156)	NC score	0.068381 (rank : 173)
Query Neighborhood Hits	157	Target Neighborhood Hits	175	Shared Neighborhood Hits	41
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	8.99809 (rank : 157)	NC score	0.069009 (rank : 172)
Query Neighborhood Hits	157	Target Neighborhood Hits	171	Shared Neighborhood Hits	41
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

ABL1_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.050196 (rank : 219)
Query Neighborhood Hits	157	Target Neighborhood Hits	1220	Shared Neighborhood Hits	31
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.050380 (rank : 218)
Query Neighborhood Hits	157	Target Neighborhood Hits	1178	Shared Neighborhood Hits	30
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BLNK_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.057477 (rank : 195)
Query Neighborhood Hits	157	Target Neighborhood Hits	228	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.057972 (rank : 193)
Query Neighborhood Hits	157	Target Neighborhood Hits	296	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

CEND2_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.057826 (rank : 194)
Query Neighborhood Hits	157	Target Neighborhood Hits	166	Shared Neighborhood Hits	38
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CPNE1_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.077311 (rank : 162)
Query Neighborhood Hits	157	Target Neighborhood Hits	70	Shared Neighborhood Hits	52
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE1_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.096293 (rank : 137)
Query Neighborhood Hits	157	Target Neighborhood Hits	83	Shared Neighborhood Hits	56
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE2_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.098867 (rank : 134)
Query Neighborhood Hits	157	Target Neighborhood Hits	75	Shared Neighborhood Hits	51
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE2_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.102562 (rank : 132)
Query Neighborhood Hits	157	Target Neighborhood Hits	82	Shared Neighborhood Hits	54
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE3_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.097181 (rank : 136)
Query Neighborhood Hits	157	Target Neighborhood Hits	90	Shared Neighborhood Hits	54
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE4_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.060160 (rank : 184)
Query Neighborhood Hits	157	Target Neighborhood Hits	70	Shared Neighborhood Hits	48
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE4_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.058424 (rank : 190)
Query Neighborhood Hits	157	Target Neighborhood Hits	67	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

CPNE5_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.094712 (rank : 138)
Query Neighborhood Hits	157	Target Neighborhood Hits	88	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.094398 (rank : 140)
Query Neighborhood Hits	157	Target Neighborhood Hits	86	Shared Neighborhood Hits	55
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

CPNE6_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.059699 (rank : 185)
Query Neighborhood Hits	157	Target Neighborhood Hits	85	Shared Neighborhood Hits	51
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE6_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.059468 (rank : 188)
Query Neighborhood Hits	157	Target Neighborhood Hits	87	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE8_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.094244 (rank : 141)
Query Neighborhood Hits	157	Target Neighborhood Hits	86	Shared Neighborhood Hits	57
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

CPNE8_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.089927 (rank : 143)
Query Neighborhood Hits	157	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

CYH3_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.064708 (rank : 176)
Query Neighborhood Hits	157	Target Neighborhood Hits	148	Shared Neighborhood Hits	36
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH4_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.052063 (rank : 213)
Query Neighborhood Hits	157	Target Neighborhood Hits	134	Shared Neighborhood Hits	31
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

DGKK_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.054677 (rank : 205)
Query Neighborhood Hits	157	Target Neighborhood Hits	378	Shared Neighborhood Hits	29
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DYSF_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.207428 (rank : 87)
Query Neighborhood Hits	157	Target Neighborhood Hits	170	Shared Neighborhood Hits	82
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

FGR_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.050081 (rank : 221)
Query Neighborhood Hits	157	Target Neighborhood Hits	1069	Shared Neighborhood Hits	22
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

GRAP_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.054631 (rank : 206)
Query Neighborhood Hits	157	Target Neighborhood Hits	307	Shared Neighborhood Hits	12
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.053424 (rank : 209)
Query Neighborhood Hits	157	Target Neighborhood Hits	309	Shared Neighborhood Hits	12
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ITSN1_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.068004 (rank : 174)
Query Neighborhood Hits	157	Target Neighborhood Hits	1757	Shared Neighborhood Hits	75
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.069875 (rank : 170)
Query Neighborhood Hits	157	Target Neighborhood Hits	1669	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.094644 (rank : 139)
Query Neighborhood Hits	157	Target Neighborhood Hits	1173	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.088777 (rank : 144)
Query Neighborhood Hits	157	Target Neighborhood Hits	1371	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

K0528_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.213610 (rank : 82)
Query Neighborhood Hits	157	Target Neighborhood Hits	96	Shared Neighborhood Hits	65
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.213299 (rank : 83)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	65
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

MELPH_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.058500 (rank : 189)
Query Neighborhood Hits	157	Target Neighborhood Hits	145	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

MELPH_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.059518 (rank : 186)
Query Neighborhood Hits	157	Target Neighborhood Hits	112	Shared Neighborhood Hits	12
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

MYRIP_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.058168 (rank : 192)
Query Neighborhood Hits	157	Target Neighborhood Hits	269	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

MYRIP_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.058236 (rank : 191)
Query Neighborhood Hits	157	Target Neighborhood Hits	207	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

NCK1_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.056295 (rank : 201)
Query Neighborhood Hits	157	Target Neighborhood Hits	312	Shared Neighborhood Hits	12
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.055344 (rank : 204)
Query Neighborhood Hits	157	Target Neighborhood Hits	310	Shared Neighborhood Hits	12
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

PA24A_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.079415 (rank : 158)
Query Neighborhood Hits	157	Target Neighborhood Hits	88	Shared Neighborhood Hits	59
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24A_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.086235 (rank : 146)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	58
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24B_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.109141 (rank : 127)
Query Neighborhood Hits	157	Target Neighborhood Hits	89	Shared Neighborhood Hits	53
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24B_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.128431 (rank : 114)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	59
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24D_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.144524 (rank : 98)
Query Neighborhood Hits	157	Target Neighborhood Hits	97	Shared Neighborhood Hits	65
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

PA24E_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.084006 (rank : 151)
Query Neighborhood Hits	157	Target Neighborhood Hits	89	Shared Neighborhood Hits	56
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PA24E_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.100805 (rank : 133)
Query Neighborhood Hits	157	Target Neighborhood Hits	95	Shared Neighborhood Hits	59
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PA24F_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.056440 (rank : 199)
Query Neighborhood Hits	157	Target Neighborhood Hits	78	Shared Neighborhood Hits	49
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PA24F_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.071453 (rank : 168)
Query Neighborhood Hits	157	Target Neighborhood Hits	93	Shared Neighborhood Hits	52
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PERF_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.051304 (rank : 214)
Query Neighborhood Hits	157	Target Neighborhood Hits	48	Shared Neighborhood Hits	15
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

PERF_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.062464 (rank : 178)
Query Neighborhood Hits	157	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	P10820	Gene names	Prf1, Pfp
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (Cytolysin).

PKHA4_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.050880 (rank : 217)
Query Neighborhood Hits	157	Target Neighborhood Hits	283	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.056575 (rank : 198)
Query Neighborhood Hits	157	Target Neighborhood Hits	202	Shared Neighborhood Hits	32
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PLCD1_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.074749 (rank : 165)
Query Neighborhood Hits	157	Target Neighborhood Hits	93	Shared Neighborhood Hits	48
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PLCD1_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.053320 (rank : 210)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PLCG1_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.053038 (rank : 212)
Query Neighborhood Hits	157	Target Neighborhood Hits	293	Shared Neighborhood Hits	25
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.051273 (rank : 215)
Query Neighborhood Hits	157	Target Neighborhood Hits	314	Shared Neighborhood Hits	24
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLEK2_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.081673 (rank : 153)
Query Neighborhood Hits	157	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.080890 (rank : 154)
Query Neighborhood Hits	157	Target Neighborhood Hits	96	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.065436 (rank : 175)
Query Neighborhood Hits	157	Target Neighborhood Hits	110	Shared Neighborhood Hits	30
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.074792 (rank : 164)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

RFIP1_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.119011 (rank : 120)
Query Neighborhood Hits	157	Target Neighborhood Hits	152	Shared Neighborhood Hits	37
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RIMS1_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.219800 (rank : 81)
Query Neighborhood Hits	157	Target Neighborhood Hits	437	Shared Neighborhood Hits	72
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.226591 (rank : 76)
Query Neighborhood Hits	157	Target Neighborhood Hits	342	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.224395 (rank : 78)
Query Neighborhood Hits	157	Target Neighborhood Hits	376	Shared Neighborhood Hits	75
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS3_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.140680 (rank : 108)
Query Neighborhood Hits	157	Target Neighborhood Hits	66	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.141947 (rank : 103)
Query Neighborhood Hits	157	Target Neighborhood Hits	67	Shared Neighborhood Hits	59
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

SH21A_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.056961 (rank : 196)
Query Neighborhood Hits	157	Target Neighborhood Hits	89	Shared Neighborhood Hits	10
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.063528 (rank : 177)
Query Neighborhood Hits	157	Target Neighborhood Hits	89	Shared Neighborhood Hits	10
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SHE_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.050098 (rank : 220)
Query Neighborhood Hits	157	Target Neighborhood Hits	164	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP2_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.051164 (rank : 216)
Query Neighborhood Hits	157	Target Neighborhood Hits	139	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.056305 (rank : 200)
Query Neighborhood Hits	157	Target Neighborhood Hits	136	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SMUF1_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.079713 (rank : 157)
Query Neighborhood Hits	157	Target Neighborhood Hits	135	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.079262 (rank : 159)
Query Neighborhood Hits	157	Target Neighborhood Hits	142	Shared Neighborhood Hits	47
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.082019 (rank : 152)
Query Neighborhood Hits	157	Target Neighborhood Hits	142	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SYT13_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.276508 (rank : 60)
Query Neighborhood Hits	157	Target Neighborhood Hits	76	Shared Neighborhood Hits	59
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT13_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.273699 (rank : 62)
Query Neighborhood Hits	157	Target Neighborhood Hits	69	Shared Neighborhood Hits	57
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT14_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.246440 (rank : 71)
Query Neighborhood Hits	157	Target Neighborhood Hits	81	Shared Neighborhood Hits	51
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT14_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.248358 (rank : 69)
Query Neighborhood Hits	157	Target Neighborhood Hits	82	Shared Neighborhood Hits	53
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

TAC2N_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.144050 (rank : 99)
Query Neighborhood Hits	157	Target Neighborhood Hits	47	Shared Neighborhood Hits	34
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TAC2N_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.142623 (rank : 101)
Query Neighborhood Hits	157	Target Neighborhood Hits	43	Shared Neighborhood Hits	34
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TXK_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.061076 (rank : 181)
Query Neighborhood Hits	157	Target Neighborhood Hits	971	Shared Neighborhood Hits	21
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.061054 (rank : 182)
Query Neighborhood Hits	157	Target Neighborhood Hits	980	Shared Neighborhood Hits	22
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

UN13D_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.272228 (rank : 63)
Query Neighborhood Hits	157	Target Neighborhood Hits	117	Shared Neighborhood Hits	71
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

WWC1_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.053057 (rank : 211)
Query Neighborhood Hits	157	Target Neighborhood Hits	290	Shared Neighborhood Hits	30
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

Hits sorted by NC score

RASA2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	157
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA2_MOUSE
NC score	0.994915 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	157	Target Neighborhood Hits	159	Shared Neighborhood Hits	138
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA3_MOUSE
NC score	0.974617 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	157	Target Neighborhood Hits	144	Shared Neighborhood Hits	119
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RASA3_HUMAN
NC score	0.972038 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	157	Target Neighborhood Hits	166	Shared Neighborhood Hits	127
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASL1_MOUSE
NC score	0.855058 (rank : 5)	θ value	1.31072e-83 (rank : 6)
Query Neighborhood Hits	157	Target Neighborhood Hits	148	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL2_HUMAN
NC score	0.846629 (rank : 6)	θ value	6.93392e-93 (rank : 5)
Query Neighborhood Hits	157	Target Neighborhood Hits	161	Shared Neighborhood Hits	102
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RASL1_HUMAN
NC score	0.841474 (rank : 7)	θ value	8.22888e-78 (rank : 7)
Query Neighborhood Hits	157	Target Neighborhood Hits	142	Shared Neighborhood Hits	98
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

DAB2P_HUMAN
NC score	0.593884 (rank : 8)	θ value	2.77775e-25 (rank : 10)
Query Neighborhood Hits	157	Target Neighborhood Hits	303	Shared Neighborhood Hits	30
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

DAB2P_MOUSE
NC score	0.593806 (rank : 9)	θ value	2.12685e-25 (rank : 9)
Query Neighborhood Hits	157	Target Neighborhood Hits	284	Shared Neighborhood Hits	28
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

NGAP_HUMAN
NC score	0.558478 (rank : 10)	θ value	1.80048e-24 (rank : 12)
Query Neighborhood Hits	157	Target Neighborhood Hits	517	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

RASA1_HUMAN
NC score	0.557159 (rank : 11)	θ value	1.02001e-27 (rank : 8)
Query Neighborhood Hits	157	Target Neighborhood Hits	258	Shared Neighborhood Hits	65
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SYGP1_HUMAN
NC score	0.536514 (rank : 12)	θ value	1.05554e-24 (rank : 11)
Query Neighborhood Hits	157	Target Neighborhood Hits	589	Shared Neighborhood Hits	27
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

NF1_MOUSE
NC score	0.498996 (rank : 13)	θ value	1.92812e-18 (rank : 13)
Query Neighborhood Hits	157	Target Neighborhood Hits	62	Shared Neighborhood Hits	18
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

NF1_HUMAN
NC score	0.495659 (rank : 14)	θ value	2.7842e-17 (rank : 14)
Query Neighborhood Hits	157	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

SYT3_MOUSE
NC score	0.458124 (rank : 15)	θ value	1.80886e-08 (rank : 26)
Query Neighborhood Hits	157	Target Neighborhood Hits	147	Shared Neighborhood Hits	83
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_HUMAN
NC score	0.457276 (rank : 16)	θ value	8.11959e-09 (rank : 25)
Query Neighborhood Hits	157	Target Neighborhood Hits	145	Shared Neighborhood Hits	83
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYTL1_HUMAN
NC score	0.452636 (rank : 17)	θ value	5.08577e-11 (rank : 21)
Query Neighborhood Hits	157	Target Neighborhood Hits	227	Shared Neighborhood Hits	79
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYT5_MOUSE
NC score	0.448945 (rank : 18)	θ value	0.000121331 (rank : 55)
Query Neighborhood Hits	157	Target Neighborhood Hits	140	Shared Neighborhood Hits	83
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT5_HUMAN
NC score	0.448153 (rank : 19)	θ value	4.1701e-05 (rank : 51)
Query Neighborhood Hits	157	Target Neighborhood Hits	138	Shared Neighborhood Hits	83
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT9_HUMAN
NC score	0.446302 (rank : 20)	θ value	5.26297e-08 (rank : 27)
Query Neighborhood Hits	157	Target Neighborhood Hits	144	Shared Neighborhood Hits	84
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT7_HUMAN
NC score	0.445443 (rank : 21)	θ value	1.43324e-05 (rank : 45)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	86
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT9_MOUSE
NC score	0.441172 (rank : 22)	θ value	1.99992e-07 (rank : 29)
Query Neighborhood Hits	157	Target Neighborhood Hits	148	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

SYT2_MOUSE
NC score	0.440967 (rank : 23)	θ value	2.21117e-06 (rank : 36)
Query Neighborhood Hits	157	Target Neighborhood Hits	143	Shared Neighborhood Hits	83
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_HUMAN
NC score	0.440616 (rank : 24)	θ value	2.88788e-06 (rank : 40)
Query Neighborhood Hits	157	Target Neighborhood Hits	142	Shared Neighborhood Hits	83
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT7_MOUSE
NC score	0.439686 (rank : 25)	θ value	7.1131e-05 (rank : 53)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	86
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYTL2_HUMAN
NC score	0.439479 (rank : 26)	θ value	8.40245e-06 (rank : 43)
Query Neighborhood Hits	157	Target Neighborhood Hits	248	Shared Neighborhood Hits	85
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYT1_HUMAN
NC score	0.438897 (rank : 27)	θ value	2.44474e-05 (rank : 46)
Query Neighborhood Hits	157	Target Neighborhood Hits	150	Shared Neighborhood Hits	84
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.438886 (rank : 28)	θ value	2.44474e-05 (rank : 47)
Query Neighborhood Hits	157	Target Neighborhood Hits	150	Shared Neighborhood Hits	84
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYTL1_MOUSE
NC score	0.438640 (rank : 29)	θ value	4.30538e-10 (rank : 22)
Query Neighborhood Hits	157	Target Neighborhood Hits	314	Shared Neighborhood Hits	75
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL2_MOUSE
NC score	0.438482 (rank : 30)	θ value	1.29631e-06 (rank : 34)
Query Neighborhood Hits	157	Target Neighborhood Hits	253	Shared Neighborhood Hits	82
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYT4_MOUSE
NC score	0.436348 (rank : 31)	θ value	2.21117e-06 (rank : 37)
Query Neighborhood Hits	157	Target Neighborhood Hits	123	Shared Neighborhood Hits	80
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT4_HUMAN
NC score	0.433033 (rank : 32)	θ value	2.88788e-06 (rank : 41)
Query Neighborhood Hits	157	Target Neighborhood Hits	121	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT6_HUMAN
NC score	0.430769 (rank : 33)	θ value	0.000158464 (rank : 56)
Query Neighborhood Hits	157	Target Neighborhood Hits	138	Shared Neighborhood Hits	82
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT6_MOUSE
NC score	0.430628 (rank : 34)	θ value	0.000158464 (rank : 57)
Query Neighborhood Hits	157	Target Neighborhood Hits	132	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT11_MOUSE
NC score	0.428312 (rank : 35)	θ value	7.59969e-07 (rank : 32)
Query Neighborhood Hits	157	Target Neighborhood Hits	116	Shared Neighborhood Hits	81
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_HUMAN
NC score	0.427541 (rank : 36)	θ value	9.92553e-07 (rank : 33)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	81
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT10_MOUSE
NC score	0.427412 (rank : 37)	θ value	0.00020696 (rank : 61)
Query Neighborhood Hits	157	Target Neighborhood Hits	133	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT10_HUMAN
NC score	0.426820 (rank : 38)	θ value	0.00020696 (rank : 60)
Query Neighborhood Hits	157	Target Neighborhood Hits	134	Shared Neighborhood Hits	83
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

DOC2A_MOUSE
NC score	0.419504 (rank : 39)	θ value	0.00102713 (rank : 67)
Query Neighborhood Hits	157	Target Neighborhood Hits	140	Shared Neighborhood Hits	82
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

SYTL4_HUMAN
NC score	0.418309 (rank : 40)	θ value	6.87365e-08 (rank : 28)
Query Neighborhood Hits	157	Target Neighborhood Hits	138	Shared Neighborhood Hits	79
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
NC score	0.414657 (rank : 41)	θ value	2.13673e-09 (rank : 23)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	76
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

DOC2A_HUMAN
NC score	0.414260 (rank : 42)	θ value	0.00390308 (rank : 77)
Query Neighborhood Hits	157	Target Neighborhood Hits	144	Shared Neighborhood Hits	84
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2B_MOUSE
NC score	0.412858 (rank : 43)	θ value	0.00228821 (rank : 71)
Query Neighborhood Hits	157	Target Neighborhood Hits	169	Shared Neighborhood Hits	86
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_HUMAN
NC score	0.412241 (rank : 44)	θ value	0.00390308 (rank : 78)
Query Neighborhood Hits	157	Target Neighborhood Hits	150	Shared Neighborhood Hits	86
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

FA62A_MOUSE
NC score	0.402044 (rank : 45)	θ value	0.00020696 (rank : 58)
Query Neighborhood Hits	157	Target Neighborhood Hits	155	Shared Neighborhood Hits	88
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYTL5_HUMAN
NC score	0.400866 (rank : 46)	θ value	3.41135e-07 (rank : 31)
Query Neighborhood Hits	157	Target Neighborhood Hits	237	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYT12_MOUSE
NC score	0.395909 (rank : 47)	θ value	9.29e-05 (rank : 54)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	73
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYTL5_MOUSE
NC score	0.395715 (rank : 48)	θ value	6.43352e-06 (rank : 42)
Query Neighborhood Hits	157	Target Neighborhood Hits	154	Shared Neighborhood Hits	79
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYT12_HUMAN
NC score	0.394088 (rank : 49)	θ value	7.1131e-05 (rank : 52)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

DOC2G_MOUSE
NC score	0.390152 (rank : 50)	θ value	0.0431538 (rank : 99)
Query Neighborhood Hits	157	Target Neighborhood Hits	125	Shared Neighborhood Hits	81
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

RP3A_HUMAN
NC score	0.389424 (rank : 51)	θ value	0.0193708 (rank : 95)
Query Neighborhood Hits	157	Target Neighborhood Hits	305	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RP3A_MOUSE
NC score	0.388060 (rank : 52)	θ value	0.00665767 (rank : 85)
Query Neighborhood Hits	157	Target Neighborhood Hits	510	Shared Neighborhood Hits	86
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYTL3_MOUSE
NC score	0.387945 (rank : 53)	θ value	8.40245e-06 (rank : 44)
Query Neighborhood Hits	157	Target Neighborhood Hits	110	Shared Neighborhood Hits	69
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYT8_MOUSE
NC score	0.386188 (rank : 54)	θ value	0.00020696 (rank : 62)
Query Neighborhood Hits	157	Target Neighborhood Hits	94	Shared Neighborhood Hits	69
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

FA62A_HUMAN
NC score	0.381297 (rank : 55)	θ value	0.0113563 (rank : 90)
Query Neighborhood Hits	157	Target Neighborhood Hits	168	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYT15_HUMAN
NC score	0.369010 (rank : 56)	θ value	0.00665767 (rank : 86)
Query Neighborhood Hits	157	Target Neighborhood Hits	112	Shared Neighborhood Hits	75
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

SYT15_MOUSE
NC score	0.349588 (rank : 57)	θ value	0.00509761 (rank : 80)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	74
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

RFIP2_HUMAN
NC score	0.317817 (rank : 58)	θ value	0.000461057 (rank : 63)
Query Neighborhood Hits	157	Target Neighborhood Hits	97	Shared Neighborhood Hits	65
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

BAIP3_HUMAN
NC score	0.278721 (rank : 59)	θ value	0.279714 (rank : 115)
Query Neighborhood Hits	157	Target Neighborhood Hits	108	Shared Neighborhood Hits	72
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

SYT13_HUMAN
NC score	0.276508 (rank : 60)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	157	Target Neighborhood Hits	76	Shared Neighborhood Hits	59
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

BAIP3_MOUSE
NC score	0.274496 (rank : 61)	θ value	0.0736092 (rank : 104)
Query Neighborhood Hits	157	Target Neighborhood Hits	112	Shared Neighborhood Hits	71
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

SYT13_MOUSE
NC score	0.273699 (rank : 62)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	157	Target Neighborhood Hits	69	Shared Neighborhood Hits	57
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

UN13D_HUMAN
NC score	0.272228 (rank : 63)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	157	Target Neighborhood Hits	117	Shared Neighborhood Hits	71
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

PKHA1_MOUSE
NC score	0.272105 (rank : 64)	θ value	3.19293e-05 (rank : 49)
Query Neighborhood Hits	157	Target Neighborhood Hits	120	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_HUMAN
NC score	0.269888 (rank : 65)	θ value	3.19293e-05 (rank : 48)
Query Neighborhood Hits	157	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

UN13B_MOUSE
NC score	0.256462 (rank : 66)	θ value	0.00869519 (rank : 88)
Query Neighborhood Hits	157	Target Neighborhood Hits	210	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_HUMAN
NC score	0.252035 (rank : 67)	θ value	0.0148317 (rank : 93)
Query Neighborhood Hits	157	Target Neighborhood Hits	217	Shared Neighborhood Hits	77
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13A_HUMAN
NC score	0.251284 (rank : 68)	θ value	0.0252991 (rank : 96)
Query Neighborhood Hits	157	Target Neighborhood Hits	285	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

SYT14_MOUSE
NC score	0.248358 (rank : 69)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	157	Target Neighborhood Hits	82	Shared Neighborhood Hits	53
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

PCLO_HUMAN
NC score	0.247565 (rank : 70)	θ value	0.00390308 (rank : 79)
Query Neighborhood Hits	157	Target Neighborhood Hits	2046	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SYT14_HUMAN
NC score	0.246440 (rank : 71)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	157	Target Neighborhood Hits	81	Shared Neighborhood Hits	51
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

PKHA2_MOUSE
NC score	0.243798 (rank : 72)	θ value	4.1701e-05 (rank : 50)
Query Neighborhood Hits	157	Target Neighborhood Hits	116	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

MYOF_HUMAN
NC score	0.231428 (rank : 73)	θ value	0.00665767 (rank : 82)
Query Neighborhood Hits	157	Target Neighborhood Hits	147	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

NED4L_HUMAN
NC score	0.229602 (rank : 74)	θ value	2.88788e-06 (rank : 38)
Query Neighborhood Hits	157	Target Neighborhood Hits	238	Shared Neighborhood Hits	84
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
NC score	0.227434 (rank : 75)	θ value	2.88788e-06 (rank : 39)
Query Neighborhood Hits	157	Target Neighborhood Hits	231	Shared Neighborhood Hits	83
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

RIMS2_HUMAN
NC score	0.226591 (rank : 76)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	157	Target Neighborhood Hits	342	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

PCLO_MOUSE
NC score	0.226144 (rank : 77)	θ value	0.0736092 (rank : 105)
Query Neighborhood Hits	157	Target Neighborhood Hits	2275	Shared Neighborhood Hits	89
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RIMS2_MOUSE
NC score	0.224395 (rank : 78)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	157	Target Neighborhood Hits	376	Shared Neighborhood Hits	75
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

P3C2B_HUMAN
NC score	0.223684 (rank : 79)	θ value	0.00102713 (rank : 69)
Query Neighborhood Hits	157	Target Neighborhood Hits	148	Shared Neighborhood Hits	73
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

PKHA2_HUMAN
NC score	0.223190 (rank : 80)	θ value	0.000786445 (rank : 65)
Query Neighborhood Hits	157	Target Neighborhood Hits	119	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

RIMS1_HUMAN
NC score	0.219800 (rank : 81)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	157	Target Neighborhood Hits	437	Shared Neighborhood Hits	72
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

K0528_HUMAN
NC score	0.213610 (rank : 82)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	157	Target Neighborhood Hits	96	Shared Neighborhood Hits	65
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
NC score	0.213299 (rank : 83)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	65
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

OTOF_HUMAN
NC score	0.210622 (rank : 84)	θ value	0.279714 (rank : 116)
Query Neighborhood Hits	157	Target Neighborhood Hits	168	Shared Neighborhood Hits	68
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

DYSF_MOUSE
NC score	0.210202 (rank : 85)	θ value	6.88961 (rank : 149)
Query Neighborhood Hits	157	Target Neighborhood Hits	162	Shared Neighborhood Hits	82
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

OTOF_MOUSE
NC score	0.208634 (rank : 86)	θ value	0.279714 (rank : 117)
Query Neighborhood Hits	157	Target Neighborhood Hits	196	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

DYSF_HUMAN
NC score	0.207428 (rank : 87)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	157	Target Neighborhood Hits	170	Shared Neighborhood Hits	82
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

NEDD4_HUMAN
NC score	0.202959 (rank : 88)	θ value	0.00665767 (rank : 83)
Query Neighborhood Hits	157	Target Neighborhood Hits	214	Shared Neighborhood Hits	78
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

DAPP1_HUMAN
NC score	0.202123 (rank : 89)	θ value	0.00390308 (rank : 76)
Query Neighborhood Hits	157	Target Neighborhood Hits	227	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
NC score	0.200994 (rank : 90)	θ value	0.00298849 (rank : 73)
Query Neighborhood Hits	157	Target Neighborhood Hits	225	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

NEDD4_MOUSE
NC score	0.199617 (rank : 91)	θ value	0.000602161 (rank : 64)
Query Neighborhood Hits	157	Target Neighborhood Hits	212	Shared Neighborhood Hits	78
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

PA24D_MOUSE
NC score	0.193586 (rank : 92)	θ value	0.0193708 (rank : 94)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	68
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

P3C2A_HUMAN
NC score	0.183211 (rank : 93)	θ value	1.38821 (rank : 130)
Query Neighborhood Hits	157	Target Neighborhood Hits	188	Shared Neighborhood Hits	68
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
NC score	0.182493 (rank : 94)	θ value	1.81305 (rank : 132)
Query Neighborhood Hits	157	Target Neighborhood Hits	181	Shared Neighborhood Hits	68
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

RIMS4_MOUSE
NC score	0.171801 (rank : 95)	θ value	3.0926 (rank : 136)
Query Neighborhood Hits	157	Target Neighborhood Hits	76	Shared Neighborhood Hits	65
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_HUMAN
NC score	0.170450 (rank : 96)	θ value	3.0926 (rank : 135)
Query Neighborhood Hits	157	Target Neighborhood Hits	76	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

IQGA2_HUMAN
NC score	0.159823 (rank : 97)	θ value	0.125558 (rank : 111)
Query Neighborhood Hits	157	Target Neighborhood Hits	200	Shared Neighborhood Hits	17
SwissProt Accessions	Q13576	Gene names	IQGAP2
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP2.

PA24D_HUMAN
NC score	0.144524 (rank : 98)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	157	Target Neighborhood Hits	97	Shared Neighborhood Hits	65
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

TAC2N_HUMAN
NC score	0.144050 (rank : 99)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	157	Target Neighborhood Hits	47	Shared Neighborhood Hits	34
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

KPCG_MOUSE
NC score	0.142904 (rank : 100)	θ value	0.00665767 (rank : 81)
Query Neighborhood Hits	157	Target Neighborhood Hits	1123	Shared Neighborhood Hits	99
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

TAC2N_MOUSE
NC score	0.142623 (rank : 101)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	157	Target Neighborhood Hits	43	Shared Neighborhood Hits	34
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

KPCG_HUMAN
NC score	0.142364 (rank : 102)	θ value	0.0113563 (rank : 92)
Query Neighborhood Hits	157	Target Neighborhood Hits	1126	Shared Neighborhood Hits	100
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

RIMS3_MOUSE
NC score	0.141947 (rank : 103)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	157	Target Neighborhood Hits	67	Shared Neighborhood Hits	59
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RFIP1_HUMAN
NC score	0.141928 (rank : 104)	θ value	0.163984 (rank : 113)
Query Neighborhood Hits	157	Target Neighborhood Hits	236	Shared Neighborhood Hits	41
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

KPCB_MOUSE
NC score	0.141294 (rank : 105)	θ value	0.00298849 (rank : 75)
Query Neighborhood Hits	157	Target Neighborhood Hits	1117	Shared Neighborhood Hits	98
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_HUMAN
NC score	0.141029 (rank : 106)	θ value	0.00134147 (rank : 70)
Query Neighborhood Hits	157	Target Neighborhood Hits	1121	Shared Neighborhood Hits	98
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCA_HUMAN
NC score	0.140936 (rank : 107)	θ value	0.00020696 (rank : 59)
Query Neighborhood Hits	157	Target Neighborhood Hits	1070	Shared Neighborhood Hits	99
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

RIMS3_HUMAN
NC score	0.140680 (rank : 108)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	157	Target Neighborhood Hits	66	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

IQGA1_MOUSE
NC score	0.139654 (rank : 109)	θ value	1.81305 (rank : 131)
Query Neighborhood Hits	157	Target Neighborhood Hits	219	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JKF1	Gene names	Iqgap1
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1.

KPCA_MOUSE
NC score	0.137487 (rank : 110)	θ value	0.00102713 (rank : 68)
Query Neighborhood Hits	157	Target Neighborhood Hits	1067	Shared Neighborhood Hits	99
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

PKHA6_HUMAN
NC score	0.131631 (rank : 111)	θ value	0.00665767 (rank : 84)
Query Neighborhood Hits	157	Target Neighborhood Hits	556	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

IQGA1_HUMAN
NC score	0.129389 (rank : 112)	θ value	6.88961 (rank : 150)
Query Neighborhood Hits	157	Target Neighborhood Hits	250	Shared Neighborhood Hits	16
SwissProt Accessions	P46940	Gene names	IQGAP1, KIAA0051
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1 (p195).

PKHA6_MOUSE
NC score	0.129055 (rank : 113)	θ value	0.00228821 (rank : 72)
Query Neighborhood Hits	157	Target Neighborhood Hits	591	Shared Neighborhood Hits	41
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PA24B_MOUSE
NC score	0.128431 (rank : 114)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	59
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

DGKH_HUMAN
NC score	0.126669 (rank : 115)	θ value	0.0563607 (rank : 103)
Query Neighborhood Hits	157	Target Neighborhood Hits	255	Shared Neighborhood Hits	50
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

BMX_HUMAN
NC score	0.125775 (rank : 116)	θ value	9.26847e-13 (rank : 15)
Query Neighborhood Hits	157	Target Neighborhood Hits	942	Shared Neighborhood Hits	45
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
NC score	0.123885 (rank : 117)	θ value	1.58096e-12 (rank : 17)
Query Neighborhood Hits	157	Target Neighborhood Hits	912	Shared Neighborhood Hits	44
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

IQGA3_HUMAN
NC score	0.123587 (rank : 118)	θ value	6.88961 (rank : 151)
Query Neighborhood Hits	157	Target Neighborhood Hits	125	Shared Neighborhood Hits	17
SwissProt Accessions	Q86VI3	Gene names	IQGAP3
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP3.

RGS3_HUMAN
NC score	0.121557 (rank : 119)	θ value	0.000786445 (rank : 66)
Query Neighborhood Hits	157	Target Neighborhood Hits	1375	Shared Neighborhood Hits	72
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RFIP1_MOUSE
NC score	0.119011 (rank : 120)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	157	Target Neighborhood Hits	152	Shared Neighborhood Hits	37
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

ITK_MOUSE
NC score	0.116634 (rank : 121)	θ value	1.2105e-12 (rank : 16)
Query Neighborhood Hits	157	Target Neighborhood Hits	985	Shared Neighborhood Hits	30
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ITK_HUMAN
NC score	0.113865 (rank : 122)	θ value	2.98157e-11 (rank : 20)
Query Neighborhood Hits	157	Target Neighborhood Hits	1016	Shared Neighborhood Hits	37
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

GAB2_HUMAN
NC score	0.112066 (rank : 123)	θ value	0.125558 (rank : 110)
Query Neighborhood Hits	157	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

TEC_HUMAN
NC score	0.111907 (rank : 124)	θ value	2.13673e-09 (rank : 24)
Query Neighborhood Hits	157	Target Neighborhood Hits	1006	Shared Neighborhood Hits	44
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

GAB2_MOUSE
NC score	0.110295 (rank : 125)	θ value	0.0330416 (rank : 98)
Query Neighborhood Hits	157	Target Neighborhood Hits	220	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

DGKD_HUMAN
NC score	0.109860 (rank : 126)	θ value	0.163984 (rank : 112)
Query Neighborhood Hits	157	Target Neighborhood Hits	231	Shared Neighborhood Hits	37
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

PA24B_HUMAN
NC score	0.109141 (rank : 127)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	157	Target Neighborhood Hits	89	Shared Neighborhood Hits	53
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

BTK_MOUSE
NC score	0.107744 (rank : 128)	θ value	1.74796e-11 (rank : 19)
Query Neighborhood Hits	157	Target Neighborhood Hits	1017	Shared Neighborhood Hits	32
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

BTK_HUMAN
NC score	0.107143 (rank : 129)	θ value	1.74796e-11 (rank : 18)
Query Neighborhood Hits	157	Target Neighborhood Hits	1026	Shared Neighborhood Hits	32
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

TEC_MOUSE
NC score	0.106936 (rank : 130)	θ value	1.99992e-07 (rank : 30)
Query Neighborhood Hits	157	Target Neighborhood Hits	1006	Shared Neighborhood Hits	44
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

CPNE3_MOUSE
NC score	0.106434 (rank : 131)	θ value	6.88961 (rank : 146)
Query Neighborhood Hits	157	Target Neighborhood Hits	90	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE2_MOUSE
NC score	0.102562 (rank : 132)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	157	Target Neighborhood Hits	82	Shared Neighborhood Hits	54
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

PA24E_MOUSE
NC score	0.100805 (rank : 133)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	157	Target Neighborhood Hits	95	Shared Neighborhood Hits	59
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

CPNE2_HUMAN
NC score	0.098867 (rank : 134)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	157	Target Neighborhood Hits	75	Shared Neighborhood Hits	51
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

PKHA5_HUMAN
NC score	0.097643 (rank : 135)	θ value	3.0926 (rank : 134)
Query Neighborhood Hits	157	Target Neighborhood Hits	455	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

CPNE3_HUMAN
NC score	0.097181 (rank : 136)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	157	Target Neighborhood Hits	90	Shared Neighborhood Hits	54
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE1_MOUSE
NC score	0.096293 (rank : 137)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	157	Target Neighborhood Hits	83	Shared Neighborhood Hits	56
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE5_HUMAN
NC score	0.094712 (rank : 138)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	157	Target Neighborhood Hits	88	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

ITSN2_HUMAN
NC score	0.094644 (rank : 139)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	157	Target Neighborhood Hits	1173	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

CPNE5_MOUSE
NC score	0.094398 (rank : 140)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	157	Target Neighborhood Hits	86	Shared Neighborhood Hits	55
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

CPNE8_HUMAN
NC score	0.094244 (rank : 141)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	157	Target Neighborhood Hits	86	Shared Neighborhood Hits	57
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

GAB1_HUMAN
NC score	0.092885 (rank : 142)	θ value	1.38821 (rank : 129)
Query Neighborhood Hits	157	Target Neighborhood Hits	279	Shared Neighborhood Hits	34
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CPNE8_MOUSE
NC score	0.089927 (rank : 143)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	157	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

ITSN2_MOUSE
NC score	0.088777 (rank : 144)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	157	Target Neighborhood Hits	1371	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

CYH1_HUMAN
NC score	0.087973 (rank : 145)	θ value	1.06291 (rank : 125)
Query Neighborhood Hits	157	Target Neighborhood Hits	184	Shared Neighborhood Hits	43
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

PA24A_MOUSE
NC score	0.086235 (rank : 146)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	58
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

CEND1_HUMAN
NC score	0.085957 (rank : 147)	θ value	0.0113563 (rank : 89)
Query Neighborhood Hits	157	Target Neighborhood Hits	284	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

GAB1_MOUSE
NC score	0.085218 (rank : 148)	θ value	3.0926 (rank : 133)
Query Neighborhood Hits	157	Target Neighborhood Hits	233	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CYH1_MOUSE
NC score	0.085087 (rank : 149)	θ value	1.06291 (rank : 126)
Query Neighborhood Hits	157	Target Neighborhood Hits	176	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CPNE7_HUMAN
NC score	0.084752 (rank : 150)	θ value	6.88961 (rank : 147)
Query Neighborhood Hits	157	Target Neighborhood Hits	92	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

PA24E_HUMAN
NC score	0.084006 (rank : 151)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	157	Target Neighborhood Hits	89	Shared Neighborhood Hits	56
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

SMUF2_HUMAN
NC score	0.082019 (rank : 152)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	157	Target Neighborhood Hits	142	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

PLEK2_HUMAN
NC score	0.081673 (rank : 153)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	157	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
NC score	0.080890 (rank : 154)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	157	Target Neighborhood Hits	96	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

CENB2_HUMAN
NC score	0.080667 (rank : 155)	θ value	0.47712 (rank : 122)
Query Neighborhood Hits	157	Target Neighborhood Hits	425	Shared Neighborhood Hits	36
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

SWP70_HUMAN
NC score	0.080647 (rank : 156)	θ value	0.0736092 (rank : 106)
Query Neighborhood Hits	157	Target Neighborhood Hits	973	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SMUF1_HUMAN
NC score	0.079713 (rank : 157)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	157	Target Neighborhood Hits	135	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

PA24A_HUMAN
NC score	0.079415 (rank : 158)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	157	Target Neighborhood Hits	88	Shared Neighborhood Hits	59
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

SMUF1_MOUSE
NC score	0.079262 (rank : 159)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	157	Target Neighborhood Hits	142	Shared Neighborhood Hits	47
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

MYO10_HUMAN
NC score	0.077598 (rank : 160)	θ value	1.69304e-06 (rank : 35)
Query Neighborhood Hits	157	Target Neighborhood Hits	920	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

CYH3_HUMAN
NC score	0.077355 (rank : 161)	θ value	4.03905 (rank : 138)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	38
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CPNE1_HUMAN
NC score	0.077311 (rank : 162)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	157	Target Neighborhood Hits	70	Shared Neighborhood Hits	52
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

SWP70_MOUSE
NC score	0.076724 (rank : 163)	θ value	0.0961366 (rank : 109)
Query Neighborhood Hits	157	Target Neighborhood Hits	1097	Shared Neighborhood Hits	45
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PLEK_MOUSE
NC score	0.074792 (rank : 164)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PLCD1_HUMAN
NC score	0.074749 (rank : 165)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	157	Target Neighborhood Hits	93	Shared Neighborhood Hits	48
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

FGD5_HUMAN
NC score	0.074685 (rank : 166)	θ value	0.00298849 (rank : 74)
Query Neighborhood Hits	157	Target Neighborhood Hits	235	Shared Neighborhood Hits	22
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

CENB5_HUMAN
NC score	0.074230 (rank : 167)	θ value	0.0961366 (rank : 107)
Query Neighborhood Hits	157	Target Neighborhood Hits	395	Shared Neighborhood Hits	35
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

PA24F_MOUSE
NC score	0.071453 (rank : 168)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	157	Target Neighborhood Hits	93	Shared Neighborhood Hits	52
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

CEND1_MOUSE
NC score	0.071364 (rank : 169)	θ value	0.21417 (rank : 114)
Query Neighborhood Hits	157	Target Neighborhood Hits	260	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

ITSN1_MOUSE
NC score	0.069875 (rank : 170)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	157	Target Neighborhood Hits	1669	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

CENB1_HUMAN
NC score	0.069581 (rank : 171)	θ value	0.0330416 (rank : 97)
Query Neighborhood Hits	157	Target Neighborhood Hits	383	Shared Neighborhood Hits	34
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CYH2_MOUSE
NC score	0.069009 (rank : 172)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	157	Target Neighborhood Hits	171	Shared Neighborhood Hits	41
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.068381 (rank : 173)	θ value	8.99809 (rank : 156)
Query Neighborhood Hits	157	Target Neighborhood Hits	175	Shared Neighborhood Hits	41
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

ITSN1_HUMAN
NC score	0.068004 (rank : 174)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	157	Target Neighborhood Hits	1757	Shared Neighborhood Hits	75
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

PLEK_HUMAN
NC score	0.065436 (rank : 175)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	157	Target Neighborhood Hits	110	Shared Neighborhood Hits	30
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

CYH3_MOUSE
NC score	0.064708 (rank : 176)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	157	Target Neighborhood Hits	148	Shared Neighborhood Hits	36
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

SH21A_MOUSE
NC score	0.063528 (rank : 177)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	157	Target Neighborhood Hits	89	Shared Neighborhood Hits	10
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

PERF_MOUSE
NC score	0.062464 (rank : 178)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	157	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	P10820	Gene names	Prf1, Pfp
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (Cytolysin).

FGD5_MOUSE
NC score	0.062349 (rank : 179)	θ value	0.0113563 (rank : 91)
Query Neighborhood Hits	157	Target Neighborhood Hits	170	Shared Neighborhood Hits	16
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

P3C2G_MOUSE
NC score	0.061109 (rank : 180)	θ value	6.88961 (rank : 153)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	56
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

TXK_HUMAN
NC score	0.061076 (rank : 181)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	157	Target Neighborhood Hits	971	Shared Neighborhood Hits	21
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
NC score	0.061054 (rank : 182)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	157	Target Neighborhood Hits	980	Shared Neighborhood Hits	22
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

KPCL_MOUSE
NC score	0.060209 (rank : 183)	θ value	0.00869519 (rank : 87)
Query Neighborhood Hits	157	Target Neighborhood Hits	891	Shared Neighborhood Hits	42
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

CPNE4_HUMAN
NC score	0.060160 (rank : 184)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	157	Target Neighborhood Hits	70	Shared Neighborhood Hits	48
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE6_HUMAN
NC score	0.059699 (rank : 185)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	157	Target Neighborhood Hits	85	Shared Neighborhood Hits	51
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

MELPH_MOUSE
NC score	0.059518 (rank : 186)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	157	Target Neighborhood Hits	112	Shared Neighborhood Hits	12
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

GRB14_HUMAN
NC score	0.059479 (rank : 187)	θ value	0.0431538 (rank : 100)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	20
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

CPNE6_MOUSE
NC score	0.059468 (rank : 188)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	157	Target Neighborhood Hits	87	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

MELPH_HUMAN
NC score	0.058500 (rank : 189)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	157	Target Neighborhood Hits	145	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

CPNE4_MOUSE
NC score	0.058424 (rank : 190)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	157	Target Neighborhood Hits	67	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

MYRIP_MOUSE
NC score	0.058236 (rank : 191)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	157	Target Neighborhood Hits	207	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

MYRIP_HUMAN
NC score	0.058168 (rank : 192)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	157	Target Neighborhood Hits	269	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

BLNK_MOUSE
NC score	0.057972 (rank : 193)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	157	Target Neighborhood Hits	296	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

CEND2_HUMAN
NC score	0.057826 (rank : 194)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	157	Target Neighborhood Hits	166	Shared Neighborhood Hits	38
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

BLNK_HUMAN
NC score	0.057477 (rank : 195)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	157	Target Neighborhood Hits	228	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

SH21A_HUMAN
NC score	0.056961 (rank : 196)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	157	Target Neighborhood Hits	89	Shared Neighborhood Hits	10
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

KPCE_MOUSE
NC score	0.056829 (rank : 197)	θ value	0.0431538 (rank : 101)
Query Neighborhood Hits	157	Target Neighborhood Hits	906	Shared Neighborhood Hits	40
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

PKHA4_MOUSE
NC score	0.056575 (rank : 198)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	157	Target Neighborhood Hits	202	Shared Neighborhood Hits	32
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PA24F_HUMAN
NC score	0.056440 (rank : 199)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	157	Target Neighborhood Hits	78	Shared Neighborhood Hits	49
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

SLAP2_MOUSE
NC score	0.056305 (rank : 200)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	157	Target Neighborhood Hits	136	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

NCK1_HUMAN
NC score	0.056295 (rank : 201)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	157	Target Neighborhood Hits	312	Shared Neighborhood Hits	12
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

CENA2_HUMAN
NC score	0.056038 (rank : 202)	θ value	5.27518 (rank : 143)
Query Neighborhood Hits	157	Target Neighborhood Hits	83	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

KPCE_HUMAN
NC score	0.056011 (rank : 203)	θ value	0.0961366 (rank : 108)
Query Neighborhood Hits	157	Target Neighborhood Hits	906	Shared Neighborhood Hits	40
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

NCK2_HUMAN
NC score	0.055344 (rank : 204)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	157	Target Neighborhood Hits	310	Shared Neighborhood Hits	12
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

DGKK_HUMAN
NC score	0.054677 (rank : 205)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	157	Target Neighborhood Hits	378	Shared Neighborhood Hits	29
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

GRAP_HUMAN
NC score	0.054631 (rank : 206)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	157	Target Neighborhood Hits	307	Shared Neighborhood Hits	12
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

KPCL_HUMAN
NC score	0.054521 (rank : 207)	θ value	0.0431538 (rank : 102)
Query Neighborhood Hits	157	Target Neighborhood Hits	887	Shared Neighborhood Hits	38
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

CENA1_HUMAN
NC score	0.053455 (rank : 208)	θ value	0.365318 (rank : 118)
Query Neighborhood Hits	157	Target Neighborhood Hits	87	Shared Neighborhood Hits	27
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

GRAP_MOUSE
NC score	0.053424 (rank : 209)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	157	Target Neighborhood Hits	309	Shared Neighborhood Hits	12
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

PLCD1_MOUSE
NC score	0.053320 (rank : 210)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

WWC1_MOUSE
NC score	0.053057 (rank : 211)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	157	Target Neighborhood Hits	290	Shared Neighborhood Hits	30
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

PLCG1_HUMAN
NC score	0.053038 (rank : 212)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	157	Target Neighborhood Hits	293	Shared Neighborhood Hits	25
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CYH4_MOUSE
NC score	0.052063 (rank : 213)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	157	Target Neighborhood Hits	134	Shared Neighborhood Hits	31
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

PERF_HUMAN
NC score	0.051304 (rank : 214)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	157	Target Neighborhood Hits	48	Shared Neighborhood Hits	15
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

PLCG1_MOUSE
NC score	0.051273 (rank : 215)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	157	Target Neighborhood Hits	314	Shared Neighborhood Hits	24
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SLAP2_HUMAN
NC score	0.051164 (rank : 216)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	157	Target Neighborhood Hits	139	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

PKHA4_HUMAN
NC score	0.050880 (rank : 217)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	157	Target Neighborhood Hits	283	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

ABL1_MOUSE
NC score	0.050380 (rank : 218)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	157	Target Neighborhood Hits	1178	Shared Neighborhood Hits	30
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_HUMAN
NC score	0.050196 (rank : 219)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	157	Target Neighborhood Hits	1220	Shared Neighborhood Hits	31
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SHE_HUMAN
NC score	0.050098 (rank : 220)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	157	Target Neighborhood Hits	164	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

FGR_MOUSE
NC score	0.050081 (rank : 221)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	157	Target Neighborhood Hits	1069	Shared Neighborhood Hits	22
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

PLXA3_HUMAN
NC score	0.042703 (rank : 222)	θ value	0.365318 (rank : 119)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	10
SwissProt Accessions	P51805	Gene names	PLXNA3, PLXN4, SEX
Domain Architecture
Description	Plexin-A3 precursor (Plexin-4) (Semaphorin receptor SEX).

CNKR1_HUMAN
NC score	0.040883 (rank : 223)	θ value	8.99809 (rank : 155)
Query Neighborhood Hits	157	Target Neighborhood Hits	154	Shared Neighborhood Hits	29
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

PLXA4_MOUSE
NC score	0.034898 (rank : 224)	θ value	0.365318 (rank : 121)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	10
SwissProt Accessions	Q80UG2, Q5DTW8, Q8BKK9	Gene names	Plxna4, Kiaa1550
Domain Architecture	No domain graphic available
Description	Plexin-A4 precursor.

PLXA4_HUMAN
NC score	0.034859 (rank : 225)	θ value	0.365318 (rank : 120)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HCM2, Q6UWC6, Q6ZW89, Q8N969, Q8ND00, Q8NEN3, Q9NTD4	Gene names	PLXNA4, KIAA1550, PLXNA4A, PLXNA4B
Domain Architecture	No domain graphic available
Description	Plexin-A4 precursor.

TEX15_HUMAN
NC score	0.034248 (rank : 226)	θ value	1.06291 (rank : 128)
Query Neighborhood Hits	157	Target Neighborhood Hits	174	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXT5	Gene names	TEX15
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 15 protein.

FBX46_HUMAN
NC score	0.032294 (rank : 227)	θ value	4.03905 (rank : 139)
Query Neighborhood Hits	157	Target Neighborhood Hits	68	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PJ61	Gene names	FBXO46, FBX46, FBXO34L
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

FBX46_MOUSE
NC score	0.030978 (rank : 228)	θ value	4.03905 (rank : 140)
Query Neighborhood Hits	157	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BG80	Gene names	Fbxo46, Fbx46, Fbxo34l
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

IMA7_HUMAN
NC score	0.019712 (rank : 229)	θ value	0.47712 (rank : 123)
Query Neighborhood Hits	157	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	O60684	Gene names	KPNA6, IPOA7
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6).

IMA7_MOUSE
NC score	0.019695 (rank : 230)	θ value	0.47712 (rank : 124)
Query Neighborhood Hits	157	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	O35345, Q9CVP9	Gene names	Kpna6, Kpna5
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6 subunit) (Importin alpha S2).

STK40_HUMAN
NC score	0.018935 (rank : 231)	θ value	3.0926 (rank : 137)
Query Neighborhood Hits	157	Target Neighborhood Hits	751	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
NC score	0.017753 (rank : 232)	θ value	4.03905 (rank : 142)
Query Neighborhood Hits	157	Target Neighborhood Hits	751	Shared Neighborhood Hits	17
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

IMA2_HUMAN
NC score	0.015029 (rank : 233)	θ value	4.03905 (rank : 141)
Query Neighborhood Hits	157	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	P52292, Q9BRU5	Gene names	KPNA2, RCH1, SRP1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1).

NALP6_MOUSE
NC score	0.009415 (rank : 234)	θ value	1.06291 (rank : 127)
Query Neighborhood Hits	157	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

SMO_MOUSE
NC score	0.009220 (rank : 235)	θ value	5.27518 (rank : 145)
Query Neighborhood Hits	157	Target Neighborhood Hits	61	Shared Neighborhood Hits	4
SwissProt Accessions	P56726	Gene names	Smo, Smoh
Domain Architecture	No domain graphic available
Description	Smoothened homolog precursor (SMO).

LY9_HUMAN
NC score	0.006952 (rank : 236)	θ value	5.27518 (rank : 144)
Query Neighborhood Hits	157	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBG7, Q14775, Q5VYI3, Q9H4N5, Q9NQ24	Gene names	LY9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9) (CD229 antigen).

SMO_HUMAN
NC score	0.006576 (rank : 237)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	157	Target Neighborhood Hits	61	Shared Neighborhood Hits	3
SwissProt Accessions	Q99835	Gene names	SMO, SMOH
Domain Architecture
Description	Smoothened homolog precursor (SMO) (Gx protein).

NHERF_MOUSE
NC score	0.003085 (rank : 238)	θ value	6.88961 (rank : 152)
Query Neighborhood Hits	157	Target Neighborhood Hits	195	Shared Neighborhood Hits	3
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

DUS16_HUMAN
NC score	0.002887 (rank : 239)	θ value	6.88961 (rank : 148)
Query Neighborhood Hits	157	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BY84, Q9C0G3	Gene names	DUSP16, KIAA1700, MKP7
Domain Architecture
Description	Dual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).