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Network neighborhood for query Sequence : MELPH_HUMAN

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MELPH_HUMAN
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MELPH_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	145	Target Neighborhood Hits	145	Shared Neighborhood Hits	145
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

MELPH_MOUSE
θ value	0 (rank : 2)	NC score	0.939626 (rank : 2)
Query Neighborhood Hits	145	Target Neighborhood Hits	112	Shared Neighborhood Hits	33
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

MYRIP_MOUSE
θ value	3.37985e-39 (rank : 3)	NC score	0.740835 (rank : 3)
Query Neighborhood Hits	145	Target Neighborhood Hits	207	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

MYRIP_HUMAN
θ value	6.59618e-35 (rank : 4)	NC score	0.720170 (rank : 4)
Query Neighborhood Hits	145	Target Neighborhood Hits	269	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

SYTL4_MOUSE
θ value	8.38298e-14 (rank : 5)	NC score	0.349531 (rank : 8)
Query Neighborhood Hits	145	Target Neighborhood Hits	137	Shared Neighborhood Hits	23
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL5_HUMAN
θ value	8.67504e-11 (rank : 6)	NC score	0.354411 (rank : 6)
Query Neighborhood Hits	145	Target Neighborhood Hits	237	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL3_MOUSE
θ value	4.30538e-10 (rank : 7)	NC score	0.390502 (rank : 5)
Query Neighborhood Hits	145	Target Neighborhood Hits	110	Shared Neighborhood Hits	20
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYTL4_HUMAN
θ value	2.13673e-09 (rank : 8)	NC score	0.329866 (rank : 9)
Query Neighborhood Hits	145	Target Neighborhood Hits	138	Shared Neighborhood Hits	22
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL5_MOUSE
θ value	6.21693e-09 (rank : 9)	NC score	0.352325 (rank : 7)
Query Neighborhood Hits	145	Target Neighborhood Hits	154	Shared Neighborhood Hits	20
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL2_MOUSE
θ value	0.00035302 (rank : 10)	NC score	0.263873 (rank : 10)
Query Neighborhood Hits	145	Target Neighborhood Hits	253	Shared Neighborhood Hits	26
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

MYO9B_HUMAN
θ value	0.00175202 (rank : 11)	NC score	0.035302 (rank : 116)
Query Neighborhood Hits	145	Target Neighborhood Hits	641	Shared Neighborhood Hits	28
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

FILA_HUMAN
θ value	0.00228821 (rank : 12)	NC score	0.079616 (rank : 57)
Query Neighborhood Hits	145	Target Neighborhood Hits	685	Shared Neighborhood Hits	30
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

RP3A_MOUSE
θ value	0.00228821 (rank : 13)	NC score	0.178130 (rank : 14)
Query Neighborhood Hits	145	Target Neighborhood Hits	510	Shared Neighborhood Hits	30
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

LPIN1_MOUSE
θ value	0.00390308 (rank : 14)	NC score	0.056689 (rank : 87)
Query Neighborhood Hits	145	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q91ZP3, Q9CQI2, Q9JLG6	Gene names	Lpin1, Fld
Domain Architecture
Description	Lipin-1 (Fatty liver dystrophy protein).

RP3A_HUMAN
θ value	0.00509761 (rank : 15)	NC score	0.174438 (rank : 15)
Query Neighborhood Hits	145	Target Neighborhood Hits	305	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

PHF10_MOUSE
θ value	0.00665767 (rank : 16)	NC score	0.118844 (rank : 17)
Query Neighborhood Hits	145	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D8M7, Q99LV5	Gene names	Phf10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10.

PHF10_HUMAN
θ value	0.00869519 (rank : 17)	NC score	0.117029 (rank : 18)
Query Neighborhood Hits	145	Target Neighborhood Hits	151	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WUB8, Q2YDA3, Q9BXD2, Q9NV26	Gene names	PHF10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10 (XAP135).

MUC1_HUMAN
θ value	0.0113563 (rank : 18)	NC score	0.034391 (rank : 119)
Query Neighborhood Hits	145	Target Neighborhood Hits	975	Shared Neighborhood Hits	23
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

SRCA_HUMAN
θ value	0.0193708 (rank : 19)	NC score	0.062928 (rank : 74)
Query Neighborhood Hits	145	Target Neighborhood Hits	380	Shared Neighborhood Hits	26
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

TPR_HUMAN
θ value	0.0193708 (rank : 20)	NC score	0.035094 (rank : 117)
Query Neighborhood Hits	145	Target Neighborhood Hits	1921	Shared Neighborhood Hits	53
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

SYTL1_HUMAN
θ value	0.0431538 (rank : 21)	NC score	0.243296 (rank : 12)
Query Neighborhood Hits	145	Target Neighborhood Hits	227	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SLC2B_HUMAN
θ value	0.0563607 (rank : 22)	NC score	0.143880 (rank : 16)
Query Neighborhood Hits	145	Target Neighborhood Hits	214	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NEV8, Q9Y4D6	Gene names	EXPH5, KIAA0624, SLAC2B
Domain Architecture	No domain graphic available
Description	Slp homolog lacking C2 domains b (Exophilin-5).

TAU_HUMAN
θ value	0.0563607 (rank : 23)	NC score	0.056152 (rank : 89)
Query Neighborhood Hits	145	Target Neighborhood Hits	448	Shared Neighborhood Hits	19
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

SYTL1_MOUSE
θ value	0.0736092 (rank : 24)	NC score	0.249928 (rank : 11)
Query Neighborhood Hits	145	Target Neighborhood Hits	314	Shared Neighborhood Hits	32
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

DMP1_MOUSE
θ value	0.0961366 (rank : 25)	NC score	0.080810 (rank : 55)
Query Neighborhood Hits	145	Target Neighborhood Hits	498	Shared Neighborhood Hits	37
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

TRI44_MOUSE
θ value	0.0961366 (rank : 26)	NC score	0.068332 (rank : 67)
Query Neighborhood Hits	145	Target Neighborhood Hits	327	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QXA7, Q80SV9, Q9JHR8	Gene names	Trim44, Dipb
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB) (Protein Mc7).

HDAC5_MOUSE
θ value	0.163984 (rank : 27)	NC score	0.033329 (rank : 120)
Query Neighborhood Hits	145	Target Neighborhood Hits	310	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z2V6, Q9JL73	Gene names	Hdac5
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Histone deacetylase mHDA1).

ERIC1_HUMAN
θ value	0.21417 (rank : 28)	NC score	0.078785 (rank : 58)
Query Neighborhood Hits	145	Target Neighborhood Hits	364	Shared Neighborhood Hits	30
SwissProt Accessions	Q86X53, Q9P063	Gene names	ERICH1
Domain Architecture	No domain graphic available
Description	Glutamate-rich protein 1.

TBCD2_HUMAN
θ value	0.21417 (rank : 29)	NC score	0.044279 (rank : 104)
Query Neighborhood Hits	145	Target Neighborhood Hits	419	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

CMGA_MOUSE
θ value	0.279714 (rank : 30)	NC score	0.061992 (rank : 75)
Query Neighborhood Hits	145	Target Neighborhood Hits	172	Shared Neighborhood Hits	16
SwissProt Accessions	P26339	Gene names	Chga
Domain Architecture
Description	Chromogranin A precursor (CgA) [Contains: Pancreastatin; Beta-granin; WE-14].

K1H2_MOUSE
θ value	0.279714 (rank : 31)	NC score	0.026470 (rank : 136)
Query Neighborhood Hits	145	Target Neighborhood Hits	446	Shared Neighborhood Hits	28
SwissProt Accessions	Q62168	Gene names	Krtha2, Hka2, Krt1-2
Domain Architecture
Description	Keratin, type I cuticular Ha2 (Hair keratin, type I Ha2).

T2FA_HUMAN
θ value	0.279714 (rank : 32)	NC score	0.067378 (rank : 69)
Query Neighborhood Hits	145	Target Neighborhood Hits	228	Shared Neighborhood Hits	16
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

FGD1_HUMAN
θ value	0.365318 (rank : 33)	NC score	0.076431 (rank : 61)
Query Neighborhood Hits	145	Target Neighborhood Hits	367	Shared Neighborhood Hits	21
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MDN1_HUMAN
θ value	0.365318 (rank : 34)	NC score	0.061844 (rank : 76)
Query Neighborhood Hits	145	Target Neighborhood Hits	662	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

CHD4_HUMAN
θ value	0.47712 (rank : 35)	NC score	0.035675 (rank : 114)
Query Neighborhood Hits	145	Target Neighborhood Hits	365	Shared Neighborhood Hits	22
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

FGD2_MOUSE
θ value	0.47712 (rank : 36)	NC score	0.083700 (rank : 52)
Query Neighborhood Hits	145	Target Neighborhood Hits	163	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

CHD4_MOUSE
θ value	0.62314 (rank : 37)	NC score	0.035608 (rank : 115)
Query Neighborhood Hits	145	Target Neighborhood Hits	408	Shared Neighborhood Hits	20
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

FGD1_MOUSE
θ value	0.62314 (rank : 38)	NC score	0.076302 (rank : 62)
Query Neighborhood Hits	145	Target Neighborhood Hits	387	Shared Neighborhood Hits	23
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	0.62314 (rank : 39)	NC score	0.083144 (rank : 53)
Query Neighborhood Hits	145	Target Neighborhood Hits	151	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_HUMAN
θ value	0.62314 (rank : 40)	NC score	0.072728 (rank : 65)
Query Neighborhood Hits	145	Target Neighborhood Hits	219	Shared Neighborhood Hits	22
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ZN211_HUMAN
θ value	0.62314 (rank : 41)	NC score	0.000151 (rank : 195)
Query Neighborhood Hits	145	Target Neighborhood Hits	733	Shared Neighborhood Hits	6
SwissProt Accessions	Q13398	Gene names	ZNF211
Domain Architecture	No domain graphic available
Description	Zinc finger protein 211 (Zinc finger protein C2H2-25).

KCNC3_MOUSE
θ value	0.813845 (rank : 42)	NC score	0.012925 (rank : 176)
Query Neighborhood Hits	145	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

ABCF2_MOUSE
θ value	1.06291 (rank : 43)	NC score	0.020574 (rank : 160)
Query Neighborhood Hits	145	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q99LE6, Q3UA24, Q8C1S5, Q9JL48	Gene names	Abcf2
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family F member 2.

ATF6B_HUMAN
θ value	1.06291 (rank : 44)	NC score	0.047710 (rank : 96)
Query Neighborhood Hits	145	Target Neighborhood Hits	122	Shared Neighborhood Hits	8
SwissProt Accessions	Q99941, Q13269, Q14343, Q14345, Q99635, Q99637, Q9H3V9, Q9H3W1, Q9NPL0	Gene names	CREBL1, G13
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp) (Protein G13).

BAZ1A_HUMAN
θ value	1.06291 (rank : 45)	NC score	0.049036 (rank : 95)
Query Neighborhood Hits	145	Target Neighborhood Hits	693	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NRL2, Q9NZ15, Q9P065, Q9UIG1, Q9Y3V3	Gene names	BAZ1A, ACF1, WCRF180
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1A (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (ATP-dependent chromatin remodelling protein) (Williams syndrome transcription factor-related chromatin remodeling factor 180) (WCRF180) (hWALp1) (CHRAC subunit ACF1).

CK5P2_HUMAN
θ value	1.06291 (rank : 46)	NC score	0.034906 (rank : 118)
Query Neighborhood Hits	145	Target Neighborhood Hits	1433	Shared Neighborhood Hits	49
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

HORN_HUMAN
θ value	1.06291 (rank : 47)	NC score	0.047481 (rank : 97)
Query Neighborhood Hits	145	Target Neighborhood Hits	206	Shared Neighborhood Hits	9
SwissProt Accessions	Q86YZ3	Gene names	HRNR, S100A18
Domain Architecture	No domain graphic available
Description	Hornerin.

MLL3_HUMAN
θ value	1.06291 (rank : 48)	NC score	0.060438 (rank : 80)
Query Neighborhood Hits	145	Target Neighborhood Hits	1644	Shared Neighborhood Hits	46
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MLL3_MOUSE
θ value	1.06291 (rank : 49)	NC score	0.061003 (rank : 79)
Query Neighborhood Hits	145	Target Neighborhood Hits	1399	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

SMC2_HUMAN
θ value	1.06291 (rank : 50)	NC score	0.027370 (rank : 133)
Query Neighborhood Hits	145	Target Neighborhood Hits	1405	Shared Neighborhood Hits	53
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

STX18_HUMAN
θ value	1.06291 (rank : 51)	NC score	0.038909 (rank : 112)
Query Neighborhood Hits	145	Target Neighborhood Hits	225	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P2W9, Q596L3, Q5TZP5	Gene names	STX18, GIG9
Domain Architecture	No domain graphic available
Description	Syntaxin-18 (Growth-inhibiting gene 9 protein).

ATF6B_MOUSE
θ value	1.38821 (rank : 52)	NC score	0.046591 (rank : 99)
Query Neighborhood Hits	145	Target Neighborhood Hits	97	Shared Neighborhood Hits	6
SwissProt Accessions	O35451	Gene names	Crebl1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp).

CDKL5_HUMAN
θ value	1.38821 (rank : 53)	NC score	0.004433 (rank : 192)
Query Neighborhood Hits	145	Target Neighborhood Hits	967	Shared Neighborhood Hits	15
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

DIAP1_HUMAN
θ value	1.38821 (rank : 54)	NC score	0.027694 (rank : 131)
Query Neighborhood Hits	145	Target Neighborhood Hits	784	Shared Neighborhood Hits	33
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

FYCO1_HUMAN
θ value	1.38821 (rank : 55)	NC score	0.042181 (rank : 107)
Query Neighborhood Hits	145	Target Neighborhood Hits	1149	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

PKHF1_MOUSE
θ value	1.38821 (rank : 56)	NC score	0.063784 (rank : 72)
Query Neighborhood Hits	145	Target Neighborhood Hits	80	Shared Neighborhood Hits	15
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

SPEG_HUMAN
θ value	1.38821 (rank : 57)	NC score	0.008648 (rank : 184)
Query Neighborhood Hits	145	Target Neighborhood Hits	1762	Shared Neighborhood Hits	26
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

MLL2_HUMAN
θ value	1.81305 (rank : 58)	NC score	0.060128 (rank : 81)
Query Neighborhood Hits	145	Target Neighborhood Hits	1788	Shared Neighborhood Hits	51
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MRCKB_HUMAN
θ value	1.81305 (rank : 59)	NC score	0.011600 (rank : 179)
Query Neighborhood Hits	145	Target Neighborhood Hits	2239	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

SPY2_HUMAN
θ value	1.81305 (rank : 60)	NC score	0.039959 (rank : 110)
Query Neighborhood Hits	145	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	O43597, Q5T6Z7	Gene names	SPRY2
Domain Architecture
Description	Sprouty homolog 2 (Spry-2).

SPY2_MOUSE
θ value	1.81305 (rank : 61)	NC score	0.040315 (rank : 109)
Query Neighborhood Hits	145	Target Neighborhood Hits	71	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QXV8, Q9WUQ9	Gene names	Spry2
Domain Architecture
Description	Sprouty homolog 2 (Spry-2).

B3A2_HUMAN
θ value	2.36792 (rank : 62)	NC score	0.012385 (rank : 177)
Query Neighborhood Hits	145	Target Neighborhood Hits	57	Shared Neighborhood Hits	4
SwissProt Accessions	P04920, Q45EY5, Q969L3	Gene names	SLC4A2, AE2, EPB3L1, HKB3, MPB3L
Domain Architecture
Description	Anion exchange protein 2 (Non-erythroid band 3-like protein) (AE2 anion exchanger) (Solute carrier family 4 member 2) (BND3L).

KRHB3_HUMAN
θ value	2.36792 (rank : 63)	NC score	0.022215 (rank : 149)
Query Neighborhood Hits	145	Target Neighborhood Hits	438	Shared Neighborhood Hits	27
SwissProt Accessions	P78385, Q9NSB3	Gene names	KRTHB3
Domain Architecture
Description	Keratin, type II cuticular Hb3 (Hair keratin, type II Hb3).

LMNB1_MOUSE
θ value	2.36792 (rank : 64)	NC score	0.029091 (rank : 128)
Query Neighborhood Hits	145	Target Neighborhood Hits	719	Shared Neighborhood Hits	35
SwissProt Accessions	P14733, Q61791	Gene names	Lmnb1
Domain Architecture
Description	Lamin-B1.

MYCL2_HUMAN
θ value	2.36792 (rank : 65)	NC score	0.022230 (rank : 148)
Query Neighborhood Hits	145	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

SPRL1_MOUSE
θ value	2.36792 (rank : 66)	NC score	0.038921 (rank : 111)
Query Neighborhood Hits	145	Target Neighborhood Hits	403	Shared Neighborhood Hits	31
SwissProt Accessions	P70663, P97810, Q99L82	Gene names	Sparcl1, Ecm2, Sc1
Domain Architecture
Description	SPARC-like protein 1 precursor (Matrix glycoprotein Sc1) (Extracellular matrix protein 2).

ZFYV1_HUMAN
θ value	2.36792 (rank : 67)	NC score	0.046475 (rank : 100)
Query Neighborhood Hits	145	Target Neighborhood Hits	166	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

CCHCR_MOUSE
θ value	3.0926 (rank : 68)	NC score	0.029124 (rank : 127)
Query Neighborhood Hits	145	Target Neighborhood Hits	932	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

CENPB_HUMAN
θ value	3.0926 (rank : 69)	NC score	0.033158 (rank : 121)
Query Neighborhood Hits	145	Target Neighborhood Hits	133	Shared Neighborhood Hits	15
SwissProt Accessions	P07199	Gene names	CENPB
Domain Architecture
Description	Major centromere autoantigen B (Centromere protein B) (CENP-B).

EVX1_MOUSE
θ value	3.0926 (rank : 70)	NC score	0.006184 (rank : 186)
Query Neighborhood Hits	145	Target Neighborhood Hits	350	Shared Neighborhood Hits	4
SwissProt Accessions	P23683	Gene names	Evx1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

FBLI1_MOUSE
θ value	3.0926 (rank : 71)	NC score	0.009910 (rank : 183)
Query Neighborhood Hits	145	Target Neighborhood Hits	228	Shared Neighborhood Hits	4
SwissProt Accessions	Q71FD7, Q99J35	Gene names	Fblim1, Cal
Domain Architecture	No domain graphic available
Description	Filamin-binding LIM protein 1 (CSX-associated LIM).

FGD4_MOUSE
θ value	3.0926 (rank : 72)	NC score	0.063893 (rank : 71)
Query Neighborhood Hits	145	Target Neighborhood Hits	227	Shared Neighborhood Hits	21
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

JIP2_HUMAN
θ value	3.0926 (rank : 73)	NC score	0.027129 (rank : 135)
Query Neighborhood Hits	145	Target Neighborhood Hits	288	Shared Neighborhood Hits	13
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

K1H2_HUMAN
θ value	3.0926 (rank : 74)	NC score	0.023042 (rank : 146)
Query Neighborhood Hits	145	Target Neighborhood Hits	492	Shared Neighborhood Hits	26
SwissProt Accessions	Q14532	Gene names	KRTHA2, HHA2, HKA2
Domain Architecture
Description	Keratin, type I cuticular Ha2 (Hair keratin, type I Ha2).

LMNB1_HUMAN
θ value	3.0926 (rank : 75)	NC score	0.030360 (rank : 125)
Query Neighborhood Hits	145	Target Neighborhood Hits	714	Shared Neighborhood Hits	33
SwissProt Accessions	P20700, Q3SYN7, Q96EI6	Gene names	LMNB1, LMN2, LMNB
Domain Architecture
Description	Lamin-B1.

MPP10_MOUSE
θ value	3.0926 (rank : 76)	NC score	0.028727 (rank : 130)
Query Neighborhood Hits	145	Target Neighborhood Hits	251	Shared Neighborhood Hits	14
SwissProt Accessions	Q810V0	Gene names	Mphosph10
Domain Architecture	No domain graphic available
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

MYH9_MOUSE
θ value	3.0926 (rank : 77)	NC score	0.025373 (rank : 138)
Query Neighborhood Hits	145	Target Neighborhood Hits	1829	Shared Neighborhood Hits	56
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

PKHF1_HUMAN
θ value	3.0926 (rank : 78)	NC score	0.056001 (rank : 90)
Query Neighborhood Hits	145	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

RAI14_MOUSE
θ value	3.0926 (rank : 79)	NC score	0.016648 (rank : 171)
Query Neighborhood Hits	145	Target Neighborhood Hits	1505	Shared Neighborhood Hits	46
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

TGON2_HUMAN
θ value	3.0926 (rank : 80)	NC score	0.049691 (rank : 94)
Query Neighborhood Hits	145	Target Neighborhood Hits	1037	Shared Neighborhood Hits	49
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

ZFYV1_MOUSE
θ value	3.0926 (rank : 81)	NC score	0.045514 (rank : 101)
Query Neighborhood Hits	145	Target Neighborhood Hits	153	Shared Neighborhood Hits	15
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

CHD1_HUMAN
θ value	4.03905 (rank : 82)	NC score	0.024186 (rank : 141)
Query Neighborhood Hits	145	Target Neighborhood Hits	337	Shared Neighborhood Hits	18
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

FRAT1_HUMAN
θ value	4.03905 (rank : 83)	NC score	0.020951 (rank : 155)
Query Neighborhood Hits	145	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q92837, Q8NE74, Q8TDW9	Gene names	FRAT1
Domain Architecture
Description	Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas) (Frat-1).

IF39_MOUSE
θ value	4.03905 (rank : 84)	NC score	0.031234 (rank : 123)
Query Neighborhood Hits	145	Target Neighborhood Hits	206	Shared Neighborhood Hits	17
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

JIP1_HUMAN
θ value	4.03905 (rank : 85)	NC score	0.028907 (rank : 129)
Query Neighborhood Hits	145	Target Neighborhood Hits	271	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

PCDA5_HUMAN
θ value	4.03905 (rank : 86)	NC score	0.004570 (rank : 191)
Query Neighborhood Hits	145	Target Neighborhood Hits	217	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5H7, O75284, Q8N4R3	Gene names	PCDHA5
Domain Architecture
Description	Protocadherin alpha 5 precursor (PCDH-alpha5).

PCDA7_HUMAN
θ value	4.03905 (rank : 87)	NC score	0.004634 (rank : 190)
Query Neighborhood Hits	145	Target Neighborhood Hits	221	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UN72, O75282	Gene names	PCDHA7
Domain Architecture
Description	Protocadherin alpha 7 precursor (PCDH-alpha7).

SNPC2_HUMAN
θ value	4.03905 (rank : 88)	NC score	0.027223 (rank : 134)
Query Neighborhood Hits	145	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	Q13487, Q13486	Gene names	SNAPC2, SNAP45
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (snRNA- activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) (Small nuclear RNA-activating complex polypeptide 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE- binding factor subunit delta) (PTF subunit delta).

SYNP2_MOUSE
θ value	4.03905 (rank : 89)	NC score	0.019488 (rank : 163)
Query Neighborhood Hits	145	Target Neighborhood Hits	252	Shared Neighborhood Hits	9
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

TCF8_HUMAN
θ value	4.03905 (rank : 90)	NC score	0.005432 (rank : 188)
Query Neighborhood Hits	145	Target Neighborhood Hits	1057	Shared Neighborhood Hits	31
SwissProt Accessions	P37275, Q12924, Q13800	Gene names	TCF8, AREB6
Domain Architecture
Description	Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2).

ZN275_HUMAN
θ value	4.03905 (rank : 91)	NC score	-0.000370 (rank : 197)
Query Neighborhood Hits	145	Target Neighborhood Hits	761	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NSD4	Gene names	ZNF275
Domain Architecture	No domain graphic available
Description	Zinc finger protein 275.

ADA2A_HUMAN
θ value	5.27518 (rank : 92)	NC score	-0.000942 (rank : 198)
Query Neighborhood Hits	145	Target Neighborhood Hits	911	Shared Neighborhood Hits	5
SwissProt Accessions	P08913, Q2XN99, Q86TH8, Q9BZK1	Gene names	ADRA2A, ADRA2R, ADRAR
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtype C10).

ATBF1_MOUSE
θ value	5.27518 (rank : 93)	NC score	0.013079 (rank : 175)
Query Neighborhood Hits	145	Target Neighborhood Hits	1841	Shared Neighborhood Hits	45
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

ATX3_HUMAN
θ value	5.27518 (rank : 94)	NC score	0.021610 (rank : 152)
Query Neighborhood Hits	145	Target Neighborhood Hits	117	Shared Neighborhood Hits	7
SwissProt Accessions	P54252, O15284, O15285, O15286, Q8N189, Q96TC3, Q96TC4, Q9H3N0	Gene names	ATXN3, ATX3, MJD, MJD1, SCA3
Domain Architecture
Description	Ataxin-3 (EC 3.4.22.-) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein).

BRE1B_HUMAN
θ value	5.27518 (rank : 95)	NC score	0.023117 (rank : 145)
Query Neighborhood Hits	145	Target Neighborhood Hits	1040	Shared Neighborhood Hits	36
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

CLMN_HUMAN
θ value	5.27518 (rank : 96)	NC score	0.011809 (rank : 178)
Query Neighborhood Hits	145	Target Neighborhood Hits	205	Shared Neighborhood Hits	14
SwissProt Accessions	Q96JQ2, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2	Gene names	CLMN, KIAA1188
Domain Architecture
Description	Calmin.

KIF9_HUMAN
θ value	5.27518 (rank : 97)	NC score	0.005739 (rank : 187)
Query Neighborhood Hits	145	Target Neighborhood Hits	118	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HAQ2, Q86Z28, Q9H8A4	Gene names	KIF9
Domain Architecture
Description	Kinesin-like protein KIF9.

LIPA4_HUMAN
θ value	5.27518 (rank : 98)	NC score	0.018696 (rank : 167)
Query Neighborhood Hits	145	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	O75335, O94971	Gene names	PPFIA4, KIAA0897
Domain Architecture
Description	Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4).

MYH13_HUMAN
θ value	5.27518 (rank : 99)	NC score	0.026192 (rank : 137)
Query Neighborhood Hits	145	Target Neighborhood Hits	1504	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

NEK3_MOUSE
θ value	5.27518 (rank : 100)	NC score	0.000881 (rank : 194)
Query Neighborhood Hits	145	Target Neighborhood Hits	854	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

REQU_HUMAN
θ value	5.27518 (rank : 101)	NC score	0.044739 (rank : 103)
Query Neighborhood Hits	145	Target Neighborhood Hits	523	Shared Neighborhood Hits	14
SwissProt Accessions	Q92785	Gene names	DPF2, REQ, UBID4
Domain Architecture
Description	Zinc-finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2).

REQU_MOUSE
θ value	5.27518 (rank : 102)	NC score	0.045087 (rank : 102)
Query Neighborhood Hits	145	Target Neighborhood Hits	519	Shared Neighborhood Hits	15
SwissProt Accessions	Q61103, Q3UNP5, Q60663, Q9QYA3	Gene names	Dpf2, Req, Ubid4
Domain Architecture
Description	Zinc-finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2).

SCG1_MOUSE
θ value	5.27518 (rank : 103)	NC score	0.032757 (rank : 122)
Query Neighborhood Hits	145	Target Neighborhood Hits	163	Shared Neighborhood Hits	17
SwissProt Accessions	P16014	Gene names	Chgb, Scg-1, Scg1
Domain Architecture
Description	Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB).

SGOL2_HUMAN
θ value	5.27518 (rank : 104)	NC score	0.018820 (rank : 166)
Query Neighborhood Hits	145	Target Neighborhood Hits	207	Shared Neighborhood Hits	9
SwissProt Accessions	Q562F6, Q53RR9, Q53T20, Q86XY4, Q8IWK2, Q8IZK1, Q8N1Q5, Q96LQ3	Gene names	SGOL2
Domain Architecture	No domain graphic available
Description	Shugoshin-like 2 (Tripin).

SPEG_MOUSE
θ value	5.27518 (rank : 105)	NC score	0.008348 (rank : 185)
Query Neighborhood Hits	145	Target Neighborhood Hits	1959	Shared Neighborhood Hits	31
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SRRM2_HUMAN
θ value	5.27518 (rank : 106)	NC score	0.038659 (rank : 113)
Query Neighborhood Hits	145	Target Neighborhood Hits	1296	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SYTL2_HUMAN
θ value	5.27518 (rank : 107)	NC score	0.209376 (rank : 13)
Query Neighborhood Hits	145	Target Neighborhood Hits	248	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

TLN1_HUMAN
θ value	5.27518 (rank : 108)	NC score	0.015990 (rank : 173)
Query Neighborhood Hits	145	Target Neighborhood Hits	218	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
θ value	5.27518 (rank : 109)	NC score	0.016114 (rank : 172)
Query Neighborhood Hits	145	Target Neighborhood Hits	213	Shared Neighborhood Hits	8
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

TPM1_MOUSE
θ value	5.27518 (rank : 110)	NC score	0.020670 (rank : 158)
Query Neighborhood Hits	145	Target Neighborhood Hits	729	Shared Neighborhood Hits	29
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

AINX_HUMAN
θ value	6.88961 (rank : 111)	NC score	0.020581 (rank : 159)
Query Neighborhood Hits	145	Target Neighborhood Hits	442	Shared Neighborhood Hits	27
SwissProt Accessions	Q16352, Q9BRC5	Gene names	INA
Domain Architecture
Description	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (Neurofilament-66) (NF-66).

AINX_MOUSE
θ value	6.88961 (rank : 112)	NC score	0.020899 (rank : 156)
Query Neighborhood Hits	145	Target Neighborhood Hits	448	Shared Neighborhood Hits	27
SwissProt Accessions	P46660, Q61958, Q8VCW5	Gene names	Ina
Domain Architecture
Description	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (Neurofilament-66) (NF-66).

AP3B1_MOUSE
θ value	6.88961 (rank : 113)	NC score	0.025063 (rank : 139)
Query Neighborhood Hits	145	Target Neighborhood Hits	302	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

ARI5B_MOUSE
θ value	6.88961 (rank : 114)	NC score	0.015589 (rank : 174)
Query Neighborhood Hits	145	Target Neighborhood Hits	158	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BM75, Q8C0E0, Q8K4G8, Q8K4L9, Q9CU78, Q9JIX4	Gene names	Arid5b, Desrt, Mrf2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (MRF1-like) (Modulator recognition factor protein 2) (MRF-2) (Developmentally and sexually retarded with transient immune abnormalities protein).

BAZ2B_HUMAN
θ value	6.88961 (rank : 115)	NC score	0.040460 (rank : 108)
Query Neighborhood Hits	145	Target Neighborhood Hits	803	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

CTR9_HUMAN
θ value	6.88961 (rank : 116)	NC score	0.023735 (rank : 143)
Query Neighborhood Hits	145	Target Neighborhood Hits	383	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PD62, Q15015	Gene names	CTR9, KIAA0155, SH2BP1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1).

DSPP_HUMAN
θ value	6.88961 (rank : 117)	NC score	0.052772 (rank : 91)
Query Neighborhood Hits	145	Target Neighborhood Hits	645	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

GCC2_MOUSE
θ value	6.88961 (rank : 118)	NC score	0.021075 (rank : 154)
Query Neighborhood Hits	145	Target Neighborhood Hits	1619	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

GP73_MOUSE
θ value	6.88961 (rank : 119)	NC score	0.030681 (rank : 124)
Query Neighborhood Hits	145	Target Neighborhood Hits	506	Shared Neighborhood Hits	34
SwissProt Accessions	Q91XA2	Gene names	Golph2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

KLF10_HUMAN
θ value	6.88961 (rank : 120)	NC score	0.000016 (rank : 196)
Query Neighborhood Hits	145	Target Neighborhood Hits	744	Shared Neighborhood Hits	6
SwissProt Accessions	Q13118	Gene names	KLF10, TIEG, TIEG1
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 10 (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) (EGR-alpha).

MRCKB_MOUSE
θ value	6.88961 (rank : 121)	NC score	0.010437 (rank : 182)
Query Neighborhood Hits	145	Target Neighborhood Hits	2180	Shared Neighborhood Hits	50
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MYH8_HUMAN
θ value	6.88961 (rank : 122)	NC score	0.022991 (rank : 147)
Query Neighborhood Hits	145	Target Neighborhood Hits	1610	Shared Neighborhood Hits	46
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYO5B_HUMAN
θ value	6.88961 (rank : 123)	NC score	0.023559 (rank : 144)
Query Neighborhood Hits	145	Target Neighborhood Hits	911	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

NEUM_HUMAN
θ value	6.88961 (rank : 124)	NC score	0.043183 (rank : 105)
Query Neighborhood Hits	145	Target Neighborhood Hits	132	Shared Neighborhood Hits	14
SwissProt Accessions	P17677	Gene names	GAP43
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (PP46) (Neural phosphoprotein B-50).

RB6I2_MOUSE
θ value	6.88961 (rank : 125)	NC score	0.021567 (rank : 153)
Query Neighborhood Hits	145	Target Neighborhood Hits	1433	Shared Neighborhood Hits	47
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RP1L1_HUMAN
θ value	6.88961 (rank : 126)	NC score	0.042228 (rank : 106)
Query Neighborhood Hits	145	Target Neighborhood Hits	1072	Shared Neighborhood Hits	59
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

ARHG1_HUMAN
θ value	8.99809 (rank : 127)	NC score	0.020782 (rank : 157)
Query Neighborhood Hits	145	Target Neighborhood Hits	176	Shared Neighborhood Hits	12
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

CAD15_HUMAN
θ value	8.99809 (rank : 128)	NC score	0.003023 (rank : 193)
Query Neighborhood Hits	145	Target Neighborhood Hits	173	Shared Neighborhood Hits	4
SwissProt Accessions	P55291	Gene names	CDH15, CDH14, CDH3
Domain Architecture
Description	Cadherin-15 precursor (Muscle-cadherin) (M-cadherin) (Cadherin-14).

GOGA4_MOUSE
θ value	8.99809 (rank : 129)	NC score	0.022198 (rank : 150)
Query Neighborhood Hits	145	Target Neighborhood Hits	1939	Shared Neighborhood Hits	56
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

HDAC5_HUMAN
θ value	8.99809 (rank : 130)	NC score	0.024037 (rank : 142)
Query Neighborhood Hits	145	Target Neighborhood Hits	353	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UQL6, O60340, O60528, Q96DY4	Gene names	HDAC5, KIAA0600
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Antigen NY-CO-9).

K1C19_MOUSE
θ value	8.99809 (rank : 131)	NC score	0.019209 (rank : 164)
Query Neighborhood Hits	145	Target Neighborhood Hits	358	Shared Neighborhood Hits	26
SwissProt Accessions	P19001	Gene names	Krt19, Krt1-19
Domain Architecture
Description	Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19).

KRHB1_HUMAN
θ value	8.99809 (rank : 132)	NC score	0.020200 (rank : 162)
Query Neighborhood Hits	145	Target Neighborhood Hits	461	Shared Neighborhood Hits	26
SwissProt Accessions	Q14533, Q14846, Q16274, Q8WU52, Q9BR74	Gene names	KRTHB1, MLN137
Domain Architecture
Description	Keratin, type II cuticular Hb1 (Hair keratin, type II Hb1) (ghHKb1) (ghHb1) (MLN 137).

KRHB6_HUMAN
θ value	8.99809 (rank : 133)	NC score	0.020245 (rank : 161)
Query Neighborhood Hits	145	Target Neighborhood Hits	447	Shared Neighborhood Hits	27
SwissProt Accessions	O43790, P78387	Gene names	KRTHB6
Domain Architecture
Description	Keratin, type II cuticular Hb6 (Hair keratin, type II Hb6) (ghHb6).

LEO1_HUMAN
θ value	8.99809 (rank : 134)	NC score	0.046870 (rank : 98)
Query Neighborhood Hits	145	Target Neighborhood Hits	958	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

MAP1A_HUMAN
θ value	8.99809 (rank : 135)	NC score	0.029602 (rank : 126)
Query Neighborhood Hits	145	Target Neighborhood Hits	1626	Shared Neighborhood Hits	59
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

OXRP_HUMAN
θ value	8.99809 (rank : 136)	NC score	0.016982 (rank : 168)
Query Neighborhood Hits	145	Target Neighborhood Hits	544	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

PHLPP_HUMAN
θ value	8.99809 (rank : 137)	NC score	0.004802 (rank : 189)
Query Neighborhood Hits	145	Target Neighborhood Hits	604	Shared Neighborhood Hits	8
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

PK3C3_HUMAN
θ value	8.99809 (rank : 138)	NC score	0.010686 (rank : 181)
Query Neighborhood Hits	145	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
θ value	8.99809 (rank : 139)	NC score	0.010690 (rank : 180)
Query Neighborhood Hits	145	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

SACS_HUMAN
θ value	8.99809 (rank : 140)	NC score	0.016736 (rank : 169)
Query Neighborhood Hits	145	Target Neighborhood Hits	128	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZJ4, O94835	Gene names	SACS, KIAA0730
Domain Architecture
Description	Sacsin.

SACS_MOUSE
θ value	8.99809 (rank : 141)	NC score	0.016734 (rank : 170)
Query Neighborhood Hits	145	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JLC8	Gene names	Sacs
Domain Architecture
Description	Sacsin.

SMCE1_MOUSE
θ value	8.99809 (rank : 142)	NC score	0.024548 (rank : 140)
Query Neighborhood Hits	145	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	O54941, Q8BPD9	Gene names	Smarce1, Baf57
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1 (BRG1-associated factor 57).

TCOF_HUMAN
θ value	8.99809 (rank : 143)	NC score	0.027609 (rank : 132)
Query Neighborhood Hits	145	Target Neighborhood Hits	543	Shared Neighborhood Hits	20
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

UBF1_HUMAN
θ value	8.99809 (rank : 144)	NC score	0.019204 (rank : 165)
Query Neighborhood Hits	145	Target Neighborhood Hits	415	Shared Neighborhood Hits	21
SwissProt Accessions	P17480	Gene names	UBTF, UBF, UBF1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1) (Autoantigen NOR-90).

ZMY15_HUMAN
θ value	8.99809 (rank : 145)	NC score	0.021784 (rank : 151)
Query Neighborhood Hits	145	Target Neighborhood Hits	53	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H091	Gene names	ZMYND15
Domain Architecture	No domain graphic available
Description	Zinc finger MYND domain-containing protein 15.

AKA12_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.050279 (rank : 93)
Query Neighborhood Hits	145	Target Neighborhood Hits	825	Shared Neighborhood Hits	51
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

DMP1_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.058011 (rank : 85)
Query Neighborhood Hits	145	Target Neighborhood Hits	491	Shared Neighborhood Hits	33
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

DOC2A_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.113938 (rank : 21)
Query Neighborhood Hits	145	Target Neighborhood Hits	144	Shared Neighborhood Hits	11
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2A_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.114361 (rank : 20)
Query Neighborhood Hits	145	Target Neighborhood Hits	140	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2B_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.113805 (rank : 22)
Query Neighborhood Hits	145	Target Neighborhood Hits	150	Shared Neighborhood Hits	11
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.114900 (rank : 19)
Query Neighborhood Hits	145	Target Neighborhood Hits	169	Shared Neighborhood Hits	12
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2G_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.111640 (rank : 23)
Query Neighborhood Hits	145	Target Neighborhood Hits	125	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

FA62A_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.079754 (rank : 56)
Query Neighborhood Hits	145	Target Neighborhood Hits	168	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.077631 (rank : 59)
Query Neighborhood Hits	145	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FGD3_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.051139 (rank : 92)
Query Neighborhood Hits	145	Target Neighborhood Hits	249	Shared Neighborhood Hits	18
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

P3C2A_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.073234 (rank : 64)
Query Neighborhood Hits	145	Target Neighborhood Hits	188	Shared Neighborhood Hits	14
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.075291 (rank : 63)
Query Neighborhood Hits	145	Target Neighborhood Hits	181	Shared Neighborhood Hits	15
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2B_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.069092 (rank : 66)
Query Neighborhood Hits	145	Target Neighborhood Hits	148	Shared Neighborhood Hits	15
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

PCLO_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.092397 (rank : 38)
Query Neighborhood Hits	145	Target Neighborhood Hits	2046	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PCLO_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.087522 (rank : 47)
Query Neighborhood Hits	145	Target Neighborhood Hits	2275	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RASA2_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.058500 (rank : 83)
Query Neighborhood Hits	145	Target Neighborhood Hits	157	Shared Neighborhood Hits	11
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA2_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.056825 (rank : 86)
Query Neighborhood Hits	145	Target Neighborhood Hits	159	Shared Neighborhood Hits	13
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RIMS1_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.081528 (rank : 54)
Query Neighborhood Hits	145	Target Neighborhood Hits	437	Shared Neighborhood Hits	24
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.094331 (rank : 31)
Query Neighborhood Hits	145	Target Neighborhood Hits	342	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.091582 (rank : 39)
Query Neighborhood Hits	145	Target Neighborhood Hits	376	Shared Neighborhood Hits	20
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS3_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.061165 (rank : 77)
Query Neighborhood Hits	145	Target Neighborhood Hits	66	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.063689 (rank : 73)
Query Neighborhood Hits	145	Target Neighborhood Hits	67	Shared Neighborhood Hits	10
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS4_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.066854 (rank : 70)
Query Neighborhood Hits	145	Target Neighborhood Hits	76	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.067911 (rank : 68)
Query Neighborhood Hits	145	Target Neighborhood Hits	76	Shared Neighborhood Hits	11
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

SYT10_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.088877 (rank : 40)
Query Neighborhood Hits	145	Target Neighborhood Hits	134	Shared Neighborhood Hits	11
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT10_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.086318 (rank : 51)
Query Neighborhood Hits	145	Target Neighborhood Hits	133	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT11_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.087856 (rank : 46)
Query Neighborhood Hits	145	Target Neighborhood Hits	113	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.087893 (rank : 45)
Query Neighborhood Hits	145	Target Neighborhood Hits	116	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT12_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.093138 (rank : 35)
Query Neighborhood Hits	145	Target Neighborhood Hits	100	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT12_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.093534 (rank : 33)
Query Neighborhood Hits	145	Target Neighborhood Hits	102	Shared Neighborhood Hits	11
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT13_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.058235 (rank : 84)
Query Neighborhood Hits	145	Target Neighborhood Hits	76	Shared Neighborhood Hits	11
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT13_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.056180 (rank : 88)
Query Neighborhood Hits	145	Target Neighborhood Hits	69	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT14_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.061163 (rank : 78)
Query Neighborhood Hits	145	Target Neighborhood Hits	81	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT14_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.058993 (rank : 82)
Query Neighborhood Hits	145	Target Neighborhood Hits	82	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT15_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.086716 (rank : 50)
Query Neighborhood Hits	145	Target Neighborhood Hits	112	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

SYT15_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.076508 (rank : 60)
Query Neighborhood Hits	145	Target Neighborhood Hits	100	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

SYT1_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.093127 (rank : 36)
Query Neighborhood Hits	145	Target Neighborhood Hits	150	Shared Neighborhood Hits	11
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.093127 (rank : 37)
Query Neighborhood Hits	145	Target Neighborhood Hits	150	Shared Neighborhood Hits	11
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT2_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.096358 (rank : 28)
Query Neighborhood Hits	145	Target Neighborhood Hits	142	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.096534 (rank : 27)
Query Neighborhood Hits	145	Target Neighborhood Hits	143	Shared Neighborhood Hits	11
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT3_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.094473 (rank : 30)
Query Neighborhood Hits	145	Target Neighborhood Hits	145	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.094099 (rank : 32)
Query Neighborhood Hits	145	Target Neighborhood Hits	147	Shared Neighborhood Hits	12
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT4_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.088720 (rank : 42)
Query Neighborhood Hits	145	Target Neighborhood Hits	121	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT4_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.088433 (rank : 44)
Query Neighborhood Hits	145	Target Neighborhood Hits	123	Shared Neighborhood Hits	11
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT5_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.097647 (rank : 25)
Query Neighborhood Hits	145	Target Neighborhood Hits	138	Shared Neighborhood Hits	11
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT5_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.099839 (rank : 24)
Query Neighborhood Hits	145	Target Neighborhood Hits	140	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT6_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.088686 (rank : 43)
Query Neighborhood Hits	145	Target Neighborhood Hits	138	Shared Neighborhood Hits	11
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT6_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.088730 (rank : 41)
Query Neighborhood Hits	145	Target Neighborhood Hits	132	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT7_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.097013 (rank : 26)
Query Neighborhood Hits	145	Target Neighborhood Hits	137	Shared Neighborhood Hits	11
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT7_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.094800 (rank : 29)
Query Neighborhood Hits	145	Target Neighborhood Hits	137	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT8_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.093363 (rank : 34)
Query Neighborhood Hits	145	Target Neighborhood Hits	94	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

SYT9_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.086987 (rank : 48)
Query Neighborhood Hits	145	Target Neighborhood Hits	144	Shared Neighborhood Hits	11
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.086855 (rank : 49)
Query Neighborhood Hits	145	Target Neighborhood Hits	148	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

Hits sorted by NC score

MELPH_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	145	Target Neighborhood Hits	145	Shared Neighborhood Hits	145
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

MELPH_MOUSE
NC score	0.939626 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	145	Target Neighborhood Hits	112	Shared Neighborhood Hits	33
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

MYRIP_MOUSE
NC score	0.740835 (rank : 3)	θ value	3.37985e-39 (rank : 3)
Query Neighborhood Hits	145	Target Neighborhood Hits	207	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

MYRIP_HUMAN
NC score	0.720170 (rank : 4)	θ value	6.59618e-35 (rank : 4)
Query Neighborhood Hits	145	Target Neighborhood Hits	269	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

SYTL3_MOUSE
NC score	0.390502 (rank : 5)	θ value	4.30538e-10 (rank : 7)
Query Neighborhood Hits	145	Target Neighborhood Hits	110	Shared Neighborhood Hits	20
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYTL5_HUMAN
NC score	0.354411 (rank : 6)	θ value	8.67504e-11 (rank : 6)
Query Neighborhood Hits	145	Target Neighborhood Hits	237	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
NC score	0.352325 (rank : 7)	θ value	6.21693e-09 (rank : 9)
Query Neighborhood Hits	145	Target Neighborhood Hits	154	Shared Neighborhood Hits	20
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL4_MOUSE
NC score	0.349531 (rank : 8)	θ value	8.38298e-14 (rank : 5)
Query Neighborhood Hits	145	Target Neighborhood Hits	137	Shared Neighborhood Hits	23
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_HUMAN
NC score	0.329866 (rank : 9)	θ value	2.13673e-09 (rank : 8)
Query Neighborhood Hits	145	Target Neighborhood Hits	138	Shared Neighborhood Hits	22
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL2_MOUSE
NC score	0.263873 (rank : 10)	θ value	0.00035302 (rank : 10)
Query Neighborhood Hits	145	Target Neighborhood Hits	253	Shared Neighborhood Hits	26
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL1_MOUSE
NC score	0.249928 (rank : 11)	θ value	0.0736092 (rank : 24)
Query Neighborhood Hits	145	Target Neighborhood Hits	314	Shared Neighborhood Hits	32
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL1_HUMAN
NC score	0.243296 (rank : 12)	θ value	0.0431538 (rank : 21)
Query Neighborhood Hits	145	Target Neighborhood Hits	227	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL2_HUMAN
NC score	0.209376 (rank : 13)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	145	Target Neighborhood Hits	248	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

RP3A_MOUSE
NC score	0.178130 (rank : 14)	θ value	0.00228821 (rank : 13)
Query Neighborhood Hits	145	Target Neighborhood Hits	510	Shared Neighborhood Hits	30
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RP3A_HUMAN
NC score	0.174438 (rank : 15)	θ value	0.00509761 (rank : 15)
Query Neighborhood Hits	145	Target Neighborhood Hits	305	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SLC2B_HUMAN
NC score	0.143880 (rank : 16)	θ value	0.0563607 (rank : 22)
Query Neighborhood Hits	145	Target Neighborhood Hits	214	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NEV8, Q9Y4D6	Gene names	EXPH5, KIAA0624, SLAC2B
Domain Architecture	No domain graphic available
Description	Slp homolog lacking C2 domains b (Exophilin-5).

PHF10_MOUSE
NC score	0.118844 (rank : 17)	θ value	0.00665767 (rank : 16)
Query Neighborhood Hits	145	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D8M7, Q99LV5	Gene names	Phf10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10.

PHF10_HUMAN
NC score	0.117029 (rank : 18)	θ value	0.00869519 (rank : 17)
Query Neighborhood Hits	145	Target Neighborhood Hits	151	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WUB8, Q2YDA3, Q9BXD2, Q9NV26	Gene names	PHF10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10 (XAP135).

DOC2B_MOUSE
NC score	0.114900 (rank : 19)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	145	Target Neighborhood Hits	169	Shared Neighborhood Hits	12
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2A_MOUSE
NC score	0.114361 (rank : 20)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	145	Target Neighborhood Hits	140	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2A_HUMAN
NC score	0.113938 (rank : 21)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	145	Target Neighborhood Hits	144	Shared Neighborhood Hits	11
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2B_HUMAN
NC score	0.113805 (rank : 22)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	145	Target Neighborhood Hits	150	Shared Neighborhood Hits	11
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2G_MOUSE
NC score	0.111640 (rank : 23)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	145	Target Neighborhood Hits	125	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

SYT5_MOUSE
NC score	0.099839 (rank : 24)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	145	Target Neighborhood Hits	140	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT5_HUMAN
NC score	0.097647 (rank : 25)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	145	Target Neighborhood Hits	138	Shared Neighborhood Hits	11
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT7_HUMAN
NC score	0.097013 (rank : 26)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	145	Target Neighborhood Hits	137	Shared Neighborhood Hits	11
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT2_MOUSE
NC score	0.096534 (rank : 27)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	145	Target Neighborhood Hits	143	Shared Neighborhood Hits	11
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_HUMAN
NC score	0.096358 (rank : 28)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	145	Target Neighborhood Hits	142	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT7_MOUSE
NC score	0.094800 (rank : 29)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	145	Target Neighborhood Hits	137	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT3_HUMAN
NC score	0.094473 (rank : 30)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	145	Target Neighborhood Hits	145	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

RIMS2_HUMAN
NC score	0.094331 (rank : 31)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	145	Target Neighborhood Hits	342	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

SYT3_MOUSE
NC score	0.094099 (rank : 32)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	145	Target Neighborhood Hits	147	Shared Neighborhood Hits	12
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT12_MOUSE
NC score	0.093534 (rank : 33)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	145	Target Neighborhood Hits	102	Shared Neighborhood Hits	11
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT8_MOUSE
NC score	0.093363 (rank : 34)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	145	Target Neighborhood Hits	94	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

SYT12_HUMAN
NC score	0.093138 (rank : 35)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	145	Target Neighborhood Hits	100	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT1_HUMAN
NC score	0.093127 (rank : 36)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	145	Target Neighborhood Hits	150	Shared Neighborhood Hits	11
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.093127 (rank : 37)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	145	Target Neighborhood Hits	150	Shared Neighborhood Hits	11
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

PCLO_HUMAN
NC score	0.092397 (rank : 38)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	145	Target Neighborhood Hits	2046	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RIMS2_MOUSE
NC score	0.091582 (rank : 39)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	145	Target Neighborhood Hits	376	Shared Neighborhood Hits	20
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

SYT10_HUMAN
NC score	0.088877 (rank : 40)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	145	Target Neighborhood Hits	134	Shared Neighborhood Hits	11
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT6_MOUSE
NC score	0.088730 (rank : 41)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	145	Target Neighborhood Hits	132	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT4_HUMAN
NC score	0.088720 (rank : 42)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	145	Target Neighborhood Hits	121	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT6_HUMAN
NC score	0.088686 (rank : 43)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	145	Target Neighborhood Hits	138	Shared Neighborhood Hits	11
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT4_MOUSE
NC score	0.088433 (rank : 44)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	145	Target Neighborhood Hits	123	Shared Neighborhood Hits	11
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT11_MOUSE
NC score	0.087893 (rank : 45)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	145	Target Neighborhood Hits	116	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_HUMAN
NC score	0.087856 (rank : 46)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	145	Target Neighborhood Hits	113	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

PCLO_MOUSE
NC score	0.087522 (rank : 47)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	145	Target Neighborhood Hits	2275	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SYT9_HUMAN
NC score	0.086987 (rank : 48)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	145	Target Neighborhood Hits	144	Shared Neighborhood Hits	11
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
NC score	0.086855 (rank : 49)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	145	Target Neighborhood Hits	148	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

SYT15_HUMAN
NC score	0.086716 (rank : 50)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	145	Target Neighborhood Hits	112	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

SYT10_MOUSE
NC score	0.086318 (rank : 51)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	145	Target Neighborhood Hits	133	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

FGD2_MOUSE
NC score	0.083700 (rank : 52)	θ value	0.47712 (rank : 36)
Query Neighborhood Hits	145	Target Neighborhood Hits	163	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD2_HUMAN
NC score	0.083144 (rank : 53)	θ value	0.62314 (rank : 39)
Query Neighborhood Hits	145	Target Neighborhood Hits	151	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

RIMS1_HUMAN
NC score	0.081528 (rank : 54)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	145	Target Neighborhood Hits	437	Shared Neighborhood Hits	24
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

DMP1_MOUSE
NC score	0.080810 (rank : 55)	θ value	0.0961366 (rank : 25)
Query Neighborhood Hits	145	Target Neighborhood Hits	498	Shared Neighborhood Hits	37
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

FA62A_HUMAN
NC score	0.079754 (rank : 56)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	145	Target Neighborhood Hits	168	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FILA_HUMAN
NC score	0.079616 (rank : 57)	θ value	0.00228821 (rank : 12)
Query Neighborhood Hits	145	Target Neighborhood Hits	685	Shared Neighborhood Hits	30
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

ERIC1_HUMAN
NC score	0.078785 (rank : 58)	θ value	0.21417 (rank : 28)
Query Neighborhood Hits	145	Target Neighborhood Hits	364	Shared Neighborhood Hits	30
SwissProt Accessions	Q86X53, Q9P063	Gene names	ERICH1
Domain Architecture	No domain graphic available
Description	Glutamate-rich protein 1.

FA62A_MOUSE
NC score	0.077631 (rank : 59)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	145	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYT15_MOUSE
NC score	0.076508 (rank : 60)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	145	Target Neighborhood Hits	100	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

FGD1_HUMAN
NC score	0.076431 (rank : 61)	θ value	0.365318 (rank : 33)
Query Neighborhood Hits	145	Target Neighborhood Hits	367	Shared Neighborhood Hits	21
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.076302 (rank : 62)	θ value	0.62314 (rank : 38)
Query Neighborhood Hits	145	Target Neighborhood Hits	387	Shared Neighborhood Hits	23
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

P3C2A_MOUSE
NC score	0.075291 (rank : 63)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	145	Target Neighborhood Hits	181	Shared Neighborhood Hits	15
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.073234 (rank : 64)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	145	Target Neighborhood Hits	188	Shared Neighborhood Hits	14
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

FGD4_HUMAN
NC score	0.072728 (rank : 65)	θ value	0.62314 (rank : 40)
Query Neighborhood Hits	145	Target Neighborhood Hits	219	Shared Neighborhood Hits	22
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

P3C2B_HUMAN
NC score	0.069092 (rank : 66)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	145	Target Neighborhood Hits	148	Shared Neighborhood Hits	15
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

TRI44_MOUSE
NC score	0.068332 (rank : 67)	θ value	0.0961366 (rank : 26)
Query Neighborhood Hits	145	Target Neighborhood Hits	327	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QXA7, Q80SV9, Q9JHR8	Gene names	Trim44, Dipb
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB) (Protein Mc7).

RIMS4_MOUSE
NC score	0.067911 (rank : 68)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	145	Target Neighborhood Hits	76	Shared Neighborhood Hits	11
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

T2FA_HUMAN
NC score	0.067378 (rank : 69)	θ value	0.279714 (rank : 32)
Query Neighborhood Hits	145	Target Neighborhood Hits	228	Shared Neighborhood Hits	16
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

RIMS4_HUMAN
NC score	0.066854 (rank : 70)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	145	Target Neighborhood Hits	76	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

FGD4_MOUSE
NC score	0.063893 (rank : 71)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	145	Target Neighborhood Hits	227	Shared Neighborhood Hits	21
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

PKHF1_MOUSE
NC score	0.063784 (rank : 72)	θ value	1.38821 (rank : 56)
Query Neighborhood Hits	145	Target Neighborhood Hits	80	Shared Neighborhood Hits	15
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

RIMS3_MOUSE
NC score	0.063689 (rank : 73)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	145	Target Neighborhood Hits	67	Shared Neighborhood Hits	10
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

SRCA_HUMAN
NC score	0.062928 (rank : 74)	θ value	0.0193708 (rank : 19)
Query Neighborhood Hits	145	Target Neighborhood Hits	380	Shared Neighborhood Hits	26
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

CMGA_MOUSE
NC score	0.061992 (rank : 75)	θ value	0.279714 (rank : 30)
Query Neighborhood Hits	145	Target Neighborhood Hits	172	Shared Neighborhood Hits	16
SwissProt Accessions	P26339	Gene names	Chga
Domain Architecture
Description	Chromogranin A precursor (CgA) [Contains: Pancreastatin; Beta-granin; WE-14].

MDN1_HUMAN
NC score	0.061844 (rank : 76)	θ value	0.365318 (rank : 34)
Query Neighborhood Hits	145	Target Neighborhood Hits	662	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

RIMS3_HUMAN
NC score	0.061165 (rank : 77)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	145	Target Neighborhood Hits	66	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

SYT14_HUMAN
NC score	0.061163 (rank : 78)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	145	Target Neighborhood Hits	81	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

MLL3_MOUSE
NC score	0.061003 (rank : 79)	θ value	1.06291 (rank : 49)
Query Neighborhood Hits	145	Target Neighborhood Hits	1399	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MLL3_HUMAN
NC score	0.060438 (rank : 80)	θ value	1.06291 (rank : 48)
Query Neighborhood Hits	145	Target Neighborhood Hits	1644	Shared Neighborhood Hits	46
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MLL2_HUMAN
NC score	0.060128 (rank : 81)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	145	Target Neighborhood Hits	1788	Shared Neighborhood Hits	51
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

SYT14_MOUSE
NC score	0.058993 (rank : 82)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	145	Target Neighborhood Hits	82	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

RASA2_HUMAN
NC score	0.058500 (rank : 83)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	145	Target Neighborhood Hits	157	Shared Neighborhood Hits	11
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

SYT13_HUMAN
NC score	0.058235 (rank : 84)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	145	Target Neighborhood Hits	76	Shared Neighborhood Hits	11
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

DMP1_HUMAN
NC score	0.058011 (rank : 85)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	145	Target Neighborhood Hits	491	Shared Neighborhood Hits	33
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

RASA2_MOUSE
NC score	0.056825 (rank : 86)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	145	Target Neighborhood Hits	159	Shared Neighborhood Hits	13
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

LPIN1_MOUSE
NC score	0.056689 (rank : 87)	θ value	0.00390308 (rank : 14)
Query Neighborhood Hits	145	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q91ZP3, Q9CQI2, Q9JLG6	Gene names	Lpin1, Fld
Domain Architecture
Description	Lipin-1 (Fatty liver dystrophy protein).

SYT13_MOUSE
NC score	0.056180 (rank : 88)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	145	Target Neighborhood Hits	69	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

TAU_HUMAN
NC score	0.056152 (rank : 89)	θ value	0.0563607 (rank : 23)
Query Neighborhood Hits	145	Target Neighborhood Hits	448	Shared Neighborhood Hits	19
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

PKHF1_HUMAN
NC score	0.056001 (rank : 90)	θ value	3.0926 (rank : 78)
Query Neighborhood Hits	145	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

DSPP_HUMAN
NC score	0.052772 (rank : 91)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	145	Target Neighborhood Hits	645	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

FGD3_HUMAN
NC score	0.051139 (rank : 92)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	145	Target Neighborhood Hits	249	Shared Neighborhood Hits	18
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

AKA12_HUMAN
NC score	0.050279 (rank : 93)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	145	Target Neighborhood Hits	825	Shared Neighborhood Hits	51
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

TGON2_HUMAN
NC score	0.049691 (rank : 94)	θ value	3.0926 (rank : 80)
Query Neighborhood Hits	145	Target Neighborhood Hits	1037	Shared Neighborhood Hits	49
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

BAZ1A_HUMAN
NC score	0.049036 (rank : 95)	θ value	1.06291 (rank : 45)
Query Neighborhood Hits	145	Target Neighborhood Hits	693	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NRL2, Q9NZ15, Q9P065, Q9UIG1, Q9Y3V3	Gene names	BAZ1A, ACF1, WCRF180
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1A (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (ATP-dependent chromatin remodelling protein) (Williams syndrome transcription factor-related chromatin remodeling factor 180) (WCRF180) (hWALp1) (CHRAC subunit ACF1).

ATF6B_HUMAN
NC score	0.047710 (rank : 96)	θ value	1.06291 (rank : 44)
Query Neighborhood Hits	145	Target Neighborhood Hits	122	Shared Neighborhood Hits	8
SwissProt Accessions	Q99941, Q13269, Q14343, Q14345, Q99635, Q99637, Q9H3V9, Q9H3W1, Q9NPL0	Gene names	CREBL1, G13
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp) (Protein G13).

HORN_HUMAN
NC score	0.047481 (rank : 97)	θ value	1.06291 (rank : 47)
Query Neighborhood Hits	145	Target Neighborhood Hits	206	Shared Neighborhood Hits	9
SwissProt Accessions	Q86YZ3	Gene names	HRNR, S100A18
Domain Architecture	No domain graphic available
Description	Hornerin.

LEO1_HUMAN
NC score	0.046870 (rank : 98)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	145	Target Neighborhood Hits	958	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

ATF6B_MOUSE
NC score	0.046591 (rank : 99)	θ value	1.38821 (rank : 52)
Query Neighborhood Hits	145	Target Neighborhood Hits	97	Shared Neighborhood Hits	6
SwissProt Accessions	O35451	Gene names	Crebl1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp).

ZFYV1_HUMAN
NC score	0.046475 (rank : 100)	θ value	2.36792 (rank : 67)
Query Neighborhood Hits	145	Target Neighborhood Hits	166	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
NC score	0.045514 (rank : 101)	θ value	3.0926 (rank : 81)
Query Neighborhood Hits	145	Target Neighborhood Hits	153	Shared Neighborhood Hits	15
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

REQU_MOUSE
NC score	0.045087 (rank : 102)	θ value	5.27518 (rank : 102)
Query Neighborhood Hits	145	Target Neighborhood Hits	519	Shared Neighborhood Hits	15
SwissProt Accessions	Q61103, Q3UNP5, Q60663, Q9QYA3	Gene names	Dpf2, Req, Ubid4
Domain Architecture
Description	Zinc-finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2).

REQU_HUMAN
NC score	0.044739 (rank : 103)	θ value	5.27518 (rank : 101)
Query Neighborhood Hits	145	Target Neighborhood Hits	523	Shared Neighborhood Hits	14
SwissProt Accessions	Q92785	Gene names	DPF2, REQ, UBID4
Domain Architecture
Description	Zinc-finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2).

TBCD2_HUMAN
NC score	0.044279 (rank : 104)	θ value	0.21417 (rank : 29)
Query Neighborhood Hits	145	Target Neighborhood Hits	419	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

NEUM_HUMAN
NC score	0.043183 (rank : 105)	θ value	6.88961 (rank : 124)
Query Neighborhood Hits	145	Target Neighborhood Hits	132	Shared Neighborhood Hits	14
SwissProt Accessions	P17677	Gene names	GAP43
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (PP46) (Neural phosphoprotein B-50).

RP1L1_HUMAN
NC score	0.042228 (rank : 106)	θ value	6.88961 (rank : 126)
Query Neighborhood Hits	145	Target Neighborhood Hits	1072	Shared Neighborhood Hits	59
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

FYCO1_HUMAN
NC score	0.042181 (rank : 107)	θ value	1.38821 (rank : 55)
Query Neighborhood Hits	145	Target Neighborhood Hits	1149	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

BAZ2B_HUMAN
NC score	0.040460 (rank : 108)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	145	Target Neighborhood Hits	803	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

SPY2_MOUSE
NC score	0.040315 (rank : 109)	θ value	1.81305 (rank : 61)
Query Neighborhood Hits	145	Target Neighborhood Hits	71	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QXV8, Q9WUQ9	Gene names	Spry2
Domain Architecture
Description	Sprouty homolog 2 (Spry-2).

SPY2_HUMAN
NC score	0.039959 (rank : 110)	θ value	1.81305 (rank : 60)
Query Neighborhood Hits	145	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	O43597, Q5T6Z7	Gene names	SPRY2
Domain Architecture
Description	Sprouty homolog 2 (Spry-2).

SPRL1_MOUSE
NC score	0.038921 (rank : 111)	θ value	2.36792 (rank : 66)
Query Neighborhood Hits	145	Target Neighborhood Hits	403	Shared Neighborhood Hits	31
SwissProt Accessions	P70663, P97810, Q99L82	Gene names	Sparcl1, Ecm2, Sc1
Domain Architecture
Description	SPARC-like protein 1 precursor (Matrix glycoprotein Sc1) (Extracellular matrix protein 2).

STX18_HUMAN
NC score	0.038909 (rank : 112)	θ value	1.06291 (rank : 51)
Query Neighborhood Hits	145	Target Neighborhood Hits	225	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P2W9, Q596L3, Q5TZP5	Gene names	STX18, GIG9
Domain Architecture	No domain graphic available
Description	Syntaxin-18 (Growth-inhibiting gene 9 protein).

SRRM2_HUMAN
NC score	0.038659 (rank : 113)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	145	Target Neighborhood Hits	1296	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

CHD4_HUMAN
NC score	0.035675 (rank : 114)	θ value	0.47712 (rank : 35)
Query Neighborhood Hits	145	Target Neighborhood Hits	365	Shared Neighborhood Hits	22
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

CHD4_MOUSE
NC score	0.035608 (rank : 115)	θ value	0.62314 (rank : 37)
Query Neighborhood Hits	145	Target Neighborhood Hits	408	Shared Neighborhood Hits	20
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

MYO9B_HUMAN
NC score	0.035302 (rank : 116)	θ value	0.00175202 (rank : 11)
Query Neighborhood Hits	145	Target Neighborhood Hits	641	Shared Neighborhood Hits	28
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

TPR_HUMAN
NC score	0.035094 (rank : 117)	θ value	0.0193708 (rank : 20)
Query Neighborhood Hits	145	Target Neighborhood Hits	1921	Shared Neighborhood Hits	53
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

CK5P2_HUMAN
NC score	0.034906 (rank : 118)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	145	Target Neighborhood Hits	1433	Shared Neighborhood Hits	49
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

MUC1_HUMAN
NC score	0.034391 (rank : 119)	θ value	0.0113563 (rank : 18)
Query Neighborhood Hits	145	Target Neighborhood Hits	975	Shared Neighborhood Hits	23
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

HDAC5_MOUSE
NC score	0.033329 (rank : 120)	θ value	0.163984 (rank : 27)
Query Neighborhood Hits	145	Target Neighborhood Hits	310	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z2V6, Q9JL73	Gene names	Hdac5
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Histone deacetylase mHDA1).

CENPB_HUMAN
NC score	0.033158 (rank : 121)	θ value	3.0926 (rank : 69)
Query Neighborhood Hits	145	Target Neighborhood Hits	133	Shared Neighborhood Hits	15
SwissProt Accessions	P07199	Gene names	CENPB
Domain Architecture
Description	Major centromere autoantigen B (Centromere protein B) (CENP-B).

SCG1_MOUSE
NC score	0.032757 (rank : 122)	θ value	5.27518 (rank : 103)
Query Neighborhood Hits	145	Target Neighborhood Hits	163	Shared Neighborhood Hits	17
SwissProt Accessions	P16014	Gene names	Chgb, Scg-1, Scg1
Domain Architecture
Description	Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB).

IF39_MOUSE
NC score	0.031234 (rank : 123)	θ value	4.03905 (rank : 84)
Query Neighborhood Hits	145	Target Neighborhood Hits	206	Shared Neighborhood Hits	17
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

GP73_MOUSE
NC score	0.030681 (rank : 124)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	145	Target Neighborhood Hits	506	Shared Neighborhood Hits	34
SwissProt Accessions	Q91XA2	Gene names	Golph2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

LMNB1_HUMAN
NC score	0.030360 (rank : 125)	θ value	3.0926 (rank : 75)
Query Neighborhood Hits	145	Target Neighborhood Hits	714	Shared Neighborhood Hits	33
SwissProt Accessions	P20700, Q3SYN7, Q96EI6	Gene names	LMNB1, LMN2, LMNB
Domain Architecture
Description	Lamin-B1.

MAP1A_HUMAN
NC score	0.029602 (rank : 126)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	145	Target Neighborhood Hits	1626	Shared Neighborhood Hits	59
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

CCHCR_MOUSE
NC score	0.029124 (rank : 127)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	145	Target Neighborhood Hits	932	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

LMNB1_MOUSE
NC score	0.029091 (rank : 128)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	145	Target Neighborhood Hits	719	Shared Neighborhood Hits	35
SwissProt Accessions	P14733, Q61791	Gene names	Lmnb1
Domain Architecture
Description	Lamin-B1.

JIP1_HUMAN
NC score	0.028907 (rank : 129)	θ value	4.03905 (rank : 85)
Query Neighborhood Hits	145	Target Neighborhood Hits	271	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

MPP10_MOUSE
NC score	0.028727 (rank : 130)	θ value	3.0926 (rank : 76)
Query Neighborhood Hits	145	Target Neighborhood Hits	251	Shared Neighborhood Hits	14
SwissProt Accessions	Q810V0	Gene names	Mphosph10
Domain Architecture	No domain graphic available
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

DIAP1_HUMAN
NC score	0.027694 (rank : 131)	θ value	1.38821 (rank : 54)
Query Neighborhood Hits	145	Target Neighborhood Hits	784	Shared Neighborhood Hits	33
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

TCOF_HUMAN
NC score	0.027609 (rank : 132)	θ value	8.99809 (rank : 143)
Query Neighborhood Hits	145	Target Neighborhood Hits	543	Shared Neighborhood Hits	20
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

SMC2_HUMAN
NC score	0.027370 (rank : 133)	θ value	1.06291 (rank : 50)
Query Neighborhood Hits	145	Target Neighborhood Hits	1405	Shared Neighborhood Hits	53
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

SNPC2_HUMAN
NC score	0.027223 (rank : 134)	θ value	4.03905 (rank : 88)
Query Neighborhood Hits	145	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	Q13487, Q13486	Gene names	SNAPC2, SNAP45
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (snRNA- activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) (Small nuclear RNA-activating complex polypeptide 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE- binding factor subunit delta) (PTF subunit delta).

JIP2_HUMAN
NC score	0.027129 (rank : 135)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	145	Target Neighborhood Hits	288	Shared Neighborhood Hits	13
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

K1H2_MOUSE
NC score	0.026470 (rank : 136)	θ value	0.279714 (rank : 31)
Query Neighborhood Hits	145	Target Neighborhood Hits	446	Shared Neighborhood Hits	28
SwissProt Accessions	Q62168	Gene names	Krtha2, Hka2, Krt1-2
Domain Architecture
Description	Keratin, type I cuticular Ha2 (Hair keratin, type I Ha2).

MYH13_HUMAN
NC score	0.026192 (rank : 137)	θ value	5.27518 (rank : 99)
Query Neighborhood Hits	145	Target Neighborhood Hits	1504	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYH9_MOUSE
NC score	0.025373 (rank : 138)	θ value	3.0926 (rank : 77)
Query Neighborhood Hits	145	Target Neighborhood Hits	1829	Shared Neighborhood Hits	56
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

AP3B1_MOUSE
NC score	0.025063 (rank : 139)	θ value	6.88961 (rank : 113)
Query Neighborhood Hits	145	Target Neighborhood Hits	302	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

SMCE1_MOUSE
NC score	0.024548 (rank : 140)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	145	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	O54941, Q8BPD9	Gene names	Smarce1, Baf57
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1 (BRG1-associated factor 57).

CHD1_HUMAN
NC score	0.024186 (rank : 141)	θ value	4.03905 (rank : 82)
Query Neighborhood Hits	145	Target Neighborhood Hits	337	Shared Neighborhood Hits	18
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

HDAC5_HUMAN
NC score	0.024037 (rank : 142)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	145	Target Neighborhood Hits	353	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UQL6, O60340, O60528, Q96DY4	Gene names	HDAC5, KIAA0600
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Antigen NY-CO-9).

CTR9_HUMAN
NC score	0.023735 (rank : 143)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	145	Target Neighborhood Hits	383	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PD62, Q15015	Gene names	CTR9, KIAA0155, SH2BP1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1).

MYO5B_HUMAN
NC score	0.023559 (rank : 144)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	145	Target Neighborhood Hits	911	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

BRE1B_HUMAN
NC score	0.023117 (rank : 145)	θ value	5.27518 (rank : 95)
Query Neighborhood Hits	145	Target Neighborhood Hits	1040	Shared Neighborhood Hits	36
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

K1H2_HUMAN
NC score	0.023042 (rank : 146)	θ value	3.0926 (rank : 74)
Query Neighborhood Hits	145	Target Neighborhood Hits	492	Shared Neighborhood Hits	26
SwissProt Accessions	Q14532	Gene names	KRTHA2, HHA2, HKA2
Domain Architecture
Description	Keratin, type I cuticular Ha2 (Hair keratin, type I Ha2).

MYH8_HUMAN
NC score	0.022991 (rank : 147)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	145	Target Neighborhood Hits	1610	Shared Neighborhood Hits	46
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYCL2_HUMAN
NC score	0.022230 (rank : 148)	θ value	2.36792 (rank : 65)
Query Neighborhood Hits	145	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

KRHB3_HUMAN
NC score	0.022215 (rank : 149)	θ value	2.36792 (rank : 63)
Query Neighborhood Hits	145	Target Neighborhood Hits	438	Shared Neighborhood Hits	27
SwissProt Accessions	P78385, Q9NSB3	Gene names	KRTHB3
Domain Architecture
Description	Keratin, type II cuticular Hb3 (Hair keratin, type II Hb3).

GOGA4_MOUSE
NC score	0.022198 (rank : 150)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	145	Target Neighborhood Hits	1939	Shared Neighborhood Hits	56
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

ZMY15_HUMAN
NC score	0.021784 (rank : 151)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	145	Target Neighborhood Hits	53	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H091	Gene names	ZMYND15
Domain Architecture	No domain graphic available
Description	Zinc finger MYND domain-containing protein 15.

ATX3_HUMAN
NC score	0.021610 (rank : 152)	θ value	5.27518 (rank : 94)
Query Neighborhood Hits	145	Target Neighborhood Hits	117	Shared Neighborhood Hits	7
SwissProt Accessions	P54252, O15284, O15285, O15286, Q8N189, Q96TC3, Q96TC4, Q9H3N0	Gene names	ATXN3, ATX3, MJD, MJD1, SCA3
Domain Architecture
Description	Ataxin-3 (EC 3.4.22.-) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein).

RB6I2_MOUSE
NC score	0.021567 (rank : 153)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	145	Target Neighborhood Hits	1433	Shared Neighborhood Hits	47
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

GCC2_MOUSE
NC score	0.021075 (rank : 154)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	145	Target Neighborhood Hits	1619	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

FRAT1_HUMAN
NC score	0.020951 (rank : 155)	θ value	4.03905 (rank : 83)
Query Neighborhood Hits	145	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q92837, Q8NE74, Q8TDW9	Gene names	FRAT1
Domain Architecture
Description	Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas) (Frat-1).

AINX_MOUSE
NC score	0.020899 (rank : 156)	θ value	6.88961 (rank : 112)
Query Neighborhood Hits	145	Target Neighborhood Hits	448	Shared Neighborhood Hits	27
SwissProt Accessions	P46660, Q61958, Q8VCW5	Gene names	Ina
Domain Architecture
Description	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (Neurofilament-66) (NF-66).

ARHG1_HUMAN
NC score	0.020782 (rank : 157)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	145	Target Neighborhood Hits	176	Shared Neighborhood Hits	12
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

TPM1_MOUSE
NC score	0.020670 (rank : 158)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	145	Target Neighborhood Hits	729	Shared Neighborhood Hits	29
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

AINX_HUMAN
NC score	0.020581 (rank : 159)	θ value	6.88961 (rank : 111)
Query Neighborhood Hits	145	Target Neighborhood Hits	442	Shared Neighborhood Hits	27
SwissProt Accessions	Q16352, Q9BRC5	Gene names	INA
Domain Architecture
Description	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (Neurofilament-66) (NF-66).

ABCF2_MOUSE
NC score	0.020574 (rank : 160)	θ value	1.06291 (rank : 43)
Query Neighborhood Hits	145	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q99LE6, Q3UA24, Q8C1S5, Q9JL48	Gene names	Abcf2
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family F member 2.

KRHB6_HUMAN
NC score	0.020245 (rank : 161)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	145	Target Neighborhood Hits	447	Shared Neighborhood Hits	27
SwissProt Accessions	O43790, P78387	Gene names	KRTHB6
Domain Architecture
Description	Keratin, type II cuticular Hb6 (Hair keratin, type II Hb6) (ghHb6).

KRHB1_HUMAN
NC score	0.020200 (rank : 162)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	145	Target Neighborhood Hits	461	Shared Neighborhood Hits	26
SwissProt Accessions	Q14533, Q14846, Q16274, Q8WU52, Q9BR74	Gene names	KRTHB1, MLN137
Domain Architecture
Description	Keratin, type II cuticular Hb1 (Hair keratin, type II Hb1) (ghHKb1) (ghHb1) (MLN 137).

SYNP2_MOUSE
NC score	0.019488 (rank : 163)	θ value	4.03905 (rank : 89)
Query Neighborhood Hits	145	Target Neighborhood Hits	252	Shared Neighborhood Hits	9
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

K1C19_MOUSE
NC score	0.019209 (rank : 164)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	145	Target Neighborhood Hits	358	Shared Neighborhood Hits	26
SwissProt Accessions	P19001	Gene names	Krt19, Krt1-19
Domain Architecture
Description	Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19).

UBF1_HUMAN
NC score	0.019204 (rank : 165)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	145	Target Neighborhood Hits	415	Shared Neighborhood Hits	21
SwissProt Accessions	P17480	Gene names	UBTF, UBF, UBF1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1) (Autoantigen NOR-90).

SGOL2_HUMAN
NC score	0.018820 (rank : 166)	θ value	5.27518 (rank : 104)
Query Neighborhood Hits	145	Target Neighborhood Hits	207	Shared Neighborhood Hits	9
SwissProt Accessions	Q562F6, Q53RR9, Q53T20, Q86XY4, Q8IWK2, Q8IZK1, Q8N1Q5, Q96LQ3	Gene names	SGOL2
Domain Architecture	No domain graphic available
Description	Shugoshin-like 2 (Tripin).

LIPA4_HUMAN
NC score	0.018696 (rank : 167)	θ value	5.27518 (rank : 98)
Query Neighborhood Hits	145	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	O75335, O94971	Gene names	PPFIA4, KIAA0897
Domain Architecture
Description	Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4).

OXRP_HUMAN
NC score	0.016982 (rank : 168)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	145	Target Neighborhood Hits	544	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

SACS_HUMAN
NC score	0.016736 (rank : 169)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	145	Target Neighborhood Hits	128	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZJ4, O94835	Gene names	SACS, KIAA0730
Domain Architecture
Description	Sacsin.

SACS_MOUSE
NC score	0.016734 (rank : 170)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	145	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JLC8	Gene names	Sacs
Domain Architecture
Description	Sacsin.

RAI14_MOUSE
NC score	0.016648 (rank : 171)	θ value	3.0926 (rank : 79)
Query Neighborhood Hits	145	Target Neighborhood Hits	1505	Shared Neighborhood Hits	46
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

TLN1_MOUSE
NC score	0.016114 (rank : 172)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	145	Target Neighborhood Hits	213	Shared Neighborhood Hits	8
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

TLN1_HUMAN
NC score	0.015990 (rank : 173)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	145	Target Neighborhood Hits	218	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

ARI5B_MOUSE
NC score	0.015589 (rank : 174)	θ value	6.88961 (rank : 114)
Query Neighborhood Hits	145	Target Neighborhood Hits	158	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BM75, Q8C0E0, Q8K4G8, Q8K4L9, Q9CU78, Q9JIX4	Gene names	Arid5b, Desrt, Mrf2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (MRF1-like) (Modulator recognition factor protein 2) (MRF-2) (Developmentally and sexually retarded with transient immune abnormalities protein).

ATBF1_MOUSE
NC score	0.013079 (rank : 175)	θ value	5.27518 (rank : 93)
Query Neighborhood Hits	145	Target Neighborhood Hits	1841	Shared Neighborhood Hits	45
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

KCNC3_MOUSE
NC score	0.012925 (rank : 176)	θ value	0.813845 (rank : 42)
Query Neighborhood Hits	145	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

B3A2_HUMAN
NC score	0.012385 (rank : 177)	θ value	2.36792 (rank : 62)
Query Neighborhood Hits	145	Target Neighborhood Hits	57	Shared Neighborhood Hits	4
SwissProt Accessions	P04920, Q45EY5, Q969L3	Gene names	SLC4A2, AE2, EPB3L1, HKB3, MPB3L
Domain Architecture
Description	Anion exchange protein 2 (Non-erythroid band 3-like protein) (AE2 anion exchanger) (Solute carrier family 4 member 2) (BND3L).

CLMN_HUMAN
NC score	0.011809 (rank : 178)	θ value	5.27518 (rank : 96)
Query Neighborhood Hits	145	Target Neighborhood Hits	205	Shared Neighborhood Hits	14
SwissProt Accessions	Q96JQ2, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2	Gene names	CLMN, KIAA1188
Domain Architecture
Description	Calmin.

MRCKB_HUMAN
NC score	0.011600 (rank : 179)	θ value	1.81305 (rank : 59)
Query Neighborhood Hits	145	Target Neighborhood Hits	2239	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PK3C3_MOUSE
NC score	0.010690 (rank : 180)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	145	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3C3_HUMAN
NC score	0.010686 (rank : 181)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	145	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

MRCKB_MOUSE
NC score	0.010437 (rank : 182)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	145	Target Neighborhood Hits	2180	Shared Neighborhood Hits	50
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

FBLI1_MOUSE
NC score	0.009910 (rank : 183)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	145	Target Neighborhood Hits	228	Shared Neighborhood Hits	4
SwissProt Accessions	Q71FD7, Q99J35	Gene names	Fblim1, Cal
Domain Architecture	No domain graphic available
Description	Filamin-binding LIM protein 1 (CSX-associated LIM).

SPEG_HUMAN
NC score	0.008648 (rank : 184)	θ value	1.38821 (rank : 57)
Query Neighborhood Hits	145	Target Neighborhood Hits	1762	Shared Neighborhood Hits	26
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPEG_MOUSE
NC score	0.008348 (rank : 185)	θ value	5.27518 (rank : 105)
Query Neighborhood Hits	145	Target Neighborhood Hits	1959	Shared Neighborhood Hits	31
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

EVX1_MOUSE
NC score	0.006184 (rank : 186)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	145	Target Neighborhood Hits	350	Shared Neighborhood Hits	4
SwissProt Accessions	P23683	Gene names	Evx1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

KIF9_HUMAN
NC score	0.005739 (rank : 187)	θ value	5.27518 (rank : 97)
Query Neighborhood Hits	145	Target Neighborhood Hits	118	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HAQ2, Q86Z28, Q9H8A4	Gene names	KIF9
Domain Architecture
Description	Kinesin-like protein KIF9.

TCF8_HUMAN
NC score	0.005432 (rank : 188)	θ value	4.03905 (rank : 90)
Query Neighborhood Hits	145	Target Neighborhood Hits	1057	Shared Neighborhood Hits	31
SwissProt Accessions	P37275, Q12924, Q13800	Gene names	TCF8, AREB6
Domain Architecture
Description	Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2).

PHLPP_HUMAN
NC score	0.004802 (rank : 189)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	145	Target Neighborhood Hits	604	Shared Neighborhood Hits	8
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

PCDA7_HUMAN
NC score	0.004634 (rank : 190)	θ value	4.03905 (rank : 87)
Query Neighborhood Hits	145	Target Neighborhood Hits	221	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UN72, O75282	Gene names	PCDHA7
Domain Architecture
Description	Protocadherin alpha 7 precursor (PCDH-alpha7).

PCDA5_HUMAN
NC score	0.004570 (rank : 191)	θ value	4.03905 (rank : 86)
Query Neighborhood Hits	145	Target Neighborhood Hits	217	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5H7, O75284, Q8N4R3	Gene names	PCDHA5
Domain Architecture
Description	Protocadherin alpha 5 precursor (PCDH-alpha5).

CDKL5_HUMAN
NC score	0.004433 (rank : 192)	θ value	1.38821 (rank : 53)
Query Neighborhood Hits	145	Target Neighborhood Hits	967	Shared Neighborhood Hits	15
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

CAD15_HUMAN
NC score	0.003023 (rank : 193)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	145	Target Neighborhood Hits	173	Shared Neighborhood Hits	4
SwissProt Accessions	P55291	Gene names	CDH15, CDH14, CDH3
Domain Architecture
Description	Cadherin-15 precursor (Muscle-cadherin) (M-cadherin) (Cadherin-14).

NEK3_MOUSE
NC score	0.000881 (rank : 194)	θ value	5.27518 (rank : 100)
Query Neighborhood Hits	145	Target Neighborhood Hits	854	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

ZN211_HUMAN
NC score	0.000151 (rank : 195)	θ value	0.62314 (rank : 41)
Query Neighborhood Hits	145	Target Neighborhood Hits	733	Shared Neighborhood Hits	6
SwissProt Accessions	Q13398	Gene names	ZNF211
Domain Architecture	No domain graphic available
Description	Zinc finger protein 211 (Zinc finger protein C2H2-25).

KLF10_HUMAN
NC score	0.000016 (rank : 196)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	145	Target Neighborhood Hits	744	Shared Neighborhood Hits	6
SwissProt Accessions	Q13118	Gene names	KLF10, TIEG, TIEG1
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 10 (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) (EGR-alpha).

ZN275_HUMAN
NC score	-0.000370 (rank : 197)	θ value	4.03905 (rank : 91)
Query Neighborhood Hits	145	Target Neighborhood Hits	761	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NSD4	Gene names	ZNF275
Domain Architecture	No domain graphic available
Description	Zinc finger protein 275.

ADA2A_HUMAN
NC score	-0.000942 (rank : 198)	θ value	5.27518 (rank : 92)
Query Neighborhood Hits	145	Target Neighborhood Hits	911	Shared Neighborhood Hits	5
SwissProt Accessions	P08913, Q2XN99, Q86TH8, Q9BZK1	Gene names	ADRA2A, ADRA2R, ADRAR
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtype C10).