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Network neighborhood for query Sequence : SPY2_HUMAN

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SPY2_HUMAN
SwissProt Accessions	O43597, Q5T6Z7	Gene names	SPRY2
Domain Architecture
Description	Sprouty homolog 2 (Spry-2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SPY2_HUMAN
θ value	2.41524e-162 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	O43597, Q5T6Z7	Gene names	SPRY2
Domain Architecture
Description	Sprouty homolog 2 (Spry-2).

SPY2_MOUSE
θ value	2.95243e-160 (rank : 2)	NC score	0.996544 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	71	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QXV8, Q9WUQ9	Gene names	Spry2
Domain Architecture
Description	Sprouty homolog 2 (Spry-2).

SPY1_HUMAN
θ value	2.47765e-74 (rank : 3)	NC score	0.954425 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	64	Shared Neighborhood Hits	26
SwissProt Accessions	O43609, Q6PNE0	Gene names	SPRY1
Domain Architecture
Description	Sprouty homolog 1 (Spry-1).

SPY1_MOUSE
θ value	9.43692e-66 (rank : 4)	NC score	0.949069 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QXV9	Gene names	Spry1
Domain Architecture
Description	Sprouty homolog 1 (Spry-1).

SPY3_HUMAN
θ value	7.73779e-60 (rank : 5)	NC score	0.952233 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	48	Shared Neighborhood Hits	23
SwissProt Accessions	O43610	Gene names	SPRY3
Domain Architecture
Description	Sprouty homolog 3 (Spry-3).

SPY4_MOUSE
θ value	2.75849e-49 (rank : 6)	NC score	0.933341 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WTP2, Q9QXV7	Gene names	Spry4
Domain Architecture
Description	Sprouty homolog 4 (Spry-4).

SPY4_HUMAN
θ value	8.87376e-48 (rank : 7)	NC score	0.931070 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	38	Shared Neighborhood Hits	22
SwissProt Accessions	Q9C004, Q6QIX2, Q9C003	Gene names	SPRY4
Domain Architecture
Description	Sprouty homolog 4 (Spry-4).

SPRE1_HUMAN
θ value	7.34386e-10 (rank : 8)	NC score	0.520359 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	35	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z699, Q8N256	Gene names	SPRED1
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 1 (Spred-1).

SPRE1_MOUSE
θ value	7.34386e-10 (rank : 9)	NC score	0.518642 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	36	Shared Neighborhood Hits	15
SwissProt Accessions	Q924S8, Q6PET8	Gene names	Spred1
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 1 (Spred-1).

SPRE3_HUMAN
θ value	1.25267e-09 (rank : 10)	NC score	0.534470 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q2MJR0	Gene names	SPRED3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

SPRE3_MOUSE
θ value	1.25267e-09 (rank : 11)	NC score	0.525775 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	Q6P6N5, Q7TNJ8	Gene names	Spred3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

SPRE2_HUMAN
θ value	2.13673e-09 (rank : 12)	NC score	0.518198 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z698, Q2NKX6	Gene names	SPRED2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

SPRE2_MOUSE
θ value	2.13673e-09 (rank : 13)	NC score	0.514300 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	41	Shared Neighborhood Hits	14
SwissProt Accessions	Q924S7	Gene names	Spred2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

KR10B_HUMAN
θ value	0.00298849 (rank : 14)	NC score	0.108688 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	269	Shared Neighborhood Hits	32
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

KRA92_HUMAN
θ value	0.0148317 (rank : 15)	NC score	0.125769 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

KRA93_HUMAN
θ value	0.0563607 (rank : 16)	NC score	0.107539 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	203	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

FOXJ3_MOUSE
θ value	0.125558 (rank : 17)	NC score	0.029025 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BUR3, Q3UTD8	Gene names	Foxj3, Kiaa1041
Domain Architecture
Description	Forkhead box protein J3.

KRA98_HUMAN
θ value	0.125558 (rank : 18)	NC score	0.103105 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	185	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

KRA99_HUMAN
θ value	0.125558 (rank : 19)	NC score	0.104594 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	173	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYP9	Gene names	KRTAP9-9, KAP9.9, KRTAP9.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-9 (Keratin-associated protein 9.9) (Ultrahigh sulfur keratin-associated protein 9.9).

CORIN_MOUSE
θ value	0.163984 (rank : 20)	NC score	0.027198 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	451	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

FOXJ3_HUMAN
θ value	0.365318 (rank : 21)	NC score	0.023841 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	177	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UPW0, Q9NSS7	Gene names	FOXJ3, KIAA1041
Domain Architecture
Description	Forkhead box protein J3.

FBN3_HUMAN
θ value	0.62314 (rank : 22)	NC score	0.032024 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	543	Shared Neighborhood Hits	34
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

LAMC3_MOUSE
θ value	0.813845 (rank : 23)	NC score	0.034729 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	624	Shared Neighborhood Hits	33
SwissProt Accessions	Q9R0B6, Q9WTW6	Gene names	Lamc3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

FZD1_HUMAN
θ value	1.06291 (rank : 24)	NC score	0.015108 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UP38, O94815, Q549T8	Gene names	FZD1
Domain Architecture
Description	Frizzled-1 precursor (Fz-1) (hFz1) (FzE1).

LRP1B_HUMAN
θ value	1.06291 (rank : 25)	NC score	0.044476 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	602	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

NOTC4_MOUSE
θ value	1.06291 (rank : 26)	NC score	0.033208 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	872	Shared Neighborhood Hits	36
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

SREC2_MOUSE
θ value	1.06291 (rank : 27)	NC score	0.061958 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	605	Shared Neighborhood Hits	40
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

SSPO_MOUSE
θ value	1.06291 (rank : 28)	NC score	0.038784 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	800	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

ITB3_MOUSE
θ value	1.38821 (rank : 29)	NC score	0.049953 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	319	Shared Neighborhood Hits	30
SwissProt Accessions	O54890	Gene names	Itgb3
Domain Architecture
Description	Integrin beta-3 precursor (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD61 antigen).

KRA53_HUMAN
θ value	1.38821 (rank : 30)	NC score	0.055758 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	331	Shared Neighborhood Hits	32
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

SREC2_HUMAN
θ value	1.38821 (rank : 31)	NC score	0.056786 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	645	Shared Neighborhood Hits	40
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

MELPH_HUMAN
θ value	1.81305 (rank : 32)	NC score	0.039959 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	145	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

TRI42_MOUSE
θ value	1.81305 (rank : 33)	NC score	0.039521 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	316	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

ITB3_HUMAN
θ value	2.36792 (rank : 34)	NC score	0.049332 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	325	Shared Neighborhood Hits	31
SwissProt Accessions	P05106, O15495, Q13413, Q14648, Q16499	Gene names	ITGB3, GP3A
Domain Architecture
Description	Integrin beta-3 precursor (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD61 antigen).

KR511_HUMAN
θ value	2.36792 (rank : 35)	NC score	0.063231 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	231	Shared Neighborhood Hits	29
SwissProt Accessions	Q6L8G4	Gene names	KRTAP5-11, KAP5.11, KRTAP5.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-11 (Keratin-associated protein 5.11) (Ultrahigh sulfur keratin-associated protein 5.11).

LAMC3_HUMAN
θ value	2.36792 (rank : 36)	NC score	0.033271 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	588	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y6N6	Gene names	LAMC3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

LTBP2_MOUSE
θ value	2.36792 (rank : 37)	NC score	0.029803 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	617	Shared Neighborhood Hits	31
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

MELPH_MOUSE
θ value	2.36792 (rank : 38)	NC score	0.038774 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	112	Shared Neighborhood Hits	4
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

TRI42_HUMAN
θ value	2.36792 (rank : 39)	NC score	0.038949 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	283	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

JAG1_MOUSE
θ value	3.0926 (rank : 40)	NC score	0.037790 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	518	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

KAZD1_HUMAN
θ value	3.0926 (rank : 41)	NC score	0.018819 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	248	Shared Neighborhood Hits	6
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

LRP1B_MOUSE
θ value	3.0926 (rank : 42)	NC score	0.043997 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	606	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

FBX41_MOUSE
θ value	4.03905 (rank : 43)	NC score	0.012519 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	430	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NS60, Q6P7W4, Q6ZPG1	Gene names	Fbxo41, D6Ertd538e, Kiaa1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

JHD3A_HUMAN
θ value	4.03905 (rank : 44)	NC score	0.011671 (rank : 67)
Query Neighborhood Hits	66	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	O75164, Q5VVB1	Gene names	JMJD2A, JHDM3A, JMJD2, KIAA0677
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3A (EC 1.14.11.-) (Jumonji domain-containing protein 2A).

KR108_HUMAN
θ value	4.03905 (rank : 45)	NC score	0.049898 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	226	Shared Neighborhood Hits	23
SwissProt Accessions	P60410	Gene names	KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-8 (Keratin-associated protein 10.8) (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8).

LRP1_HUMAN
θ value	4.03905 (rank : 46)	NC score	0.039421 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	617	Shared Neighborhood Hits	39
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

REPS2_HUMAN
θ value	4.03905 (rank : 47)	NC score	0.023029 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	131	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

EZH1_MOUSE
θ value	5.27518 (rank : 48)	NC score	0.019280 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	126	Shared Neighborhood Hits	16
SwissProt Accessions	P70351, Q9R089	Gene names	Ezh1, Enx2
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

FBLN2_HUMAN
θ value	5.27518 (rank : 49)	NC score	0.023678 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	392	Shared Neighborhood Hits	26
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

KRA59_HUMAN
θ value	5.27518 (rank : 50)	NC score	0.064985 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	310	Shared Neighborhood Hits	32
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

LRP2_HUMAN
θ value	5.27518 (rank : 51)	NC score	0.037874 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	573	Shared Neighborhood Hits	38
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

MT4_MOUSE
θ value	5.27518 (rank : 52)	NC score	0.046520 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	102	Shared Neighborhood Hits	13
SwissProt Accessions	P47945	Gene names	Mt4
Domain Architecture	No domain graphic available
Description	Metallothionein-4 (MT-4) (Metallothionein-IV) (MT-IV).

MUC13_MOUSE
θ value	5.27518 (rank : 53)	NC score	0.022657 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	447	Shared Neighborhood Hits	19
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

ZFP13_MOUSE
θ value	5.27518 (rank : 54)	NC score	-0.001240 (rank : 73)
Query Neighborhood Hits	66	Target Neighborhood Hits	771	Shared Neighborhood Hits	4
SwissProt Accessions	P10754, Q80WS0, Q8CDD0	Gene names	Zfp13, Krox-8, Zfp-13
Domain Architecture	No domain graphic available
Description	Zinc finger protein 13 (Zfp-13) (Krox-8 protein).

ZNF12_HUMAN
θ value	5.27518 (rank : 55)	NC score	-0.000588 (rank : 71)
Query Neighborhood Hits	66	Target Neighborhood Hits	779	Shared Neighborhood Hits	5
SwissProt Accessions	P17014, Q9ULZ6	Gene names	ZNF12, GIOT3, KOX3, ZNF325
Domain Architecture	No domain graphic available
Description	Zinc finger protein 12 (Zinc finger protein KOX3) (Zinc finger protein 325) (Gonadotropin-inducible transcription repressor 3) (GIOT-3).

JAG1_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.034384 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	514	Shared Neighborhood Hits	38
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

NOTC1_MOUSE
θ value	6.88961 (rank : 57)	NC score	0.029888 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	916	Shared Neighborhood Hits	37
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

ZN234_HUMAN
θ value	6.88961 (rank : 58)	NC score	-0.001072 (rank : 72)
Query Neighborhood Hits	66	Target Neighborhood Hits	785	Shared Neighborhood Hits	5
SwissProt Accessions	Q14588, Q96IR4, Q9NS45, Q9NYT7	Gene names	ZNF234, ZNF269
Domain Architecture	No domain graphic available
Description	Zinc finger protein 234 (Zinc finger protein HZF4).

EZH1_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.016673 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	121	Shared Neighborhood Hits	16
SwissProt Accessions	Q92800, O43287, Q14459	Gene names	EZH1, KIAA0388
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

KR107_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.052987 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	330	Shared Neighborhood Hits	35
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

LY6H_HUMAN
θ value	8.99809 (rank : 61)	NC score	0.020814 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	O94772	Gene names	LY6H
Domain Architecture
Description	Lymphocyte antigen Ly-6H precursor.

MCR_HUMAN
θ value	8.99809 (rank : 62)	NC score	0.004921 (rank : 70)
Query Neighborhood Hits	66	Target Neighborhood Hits	149	Shared Neighborhood Hits	4
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

MCR_MOUSE
θ value	8.99809 (rank : 63)	NC score	0.004930 (rank : 69)
Query Neighborhood Hits	66	Target Neighborhood Hits	162	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

SI1L1_MOUSE
θ value	8.99809 (rank : 64)	NC score	0.005144 (rank : 68)
Query Neighborhood Hits	66	Target Neighborhood Hits	189	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

STAB2_HUMAN
θ value	8.99809 (rank : 65)	NC score	0.032321 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	534	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

USH2A_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.025467 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	600	Shared Neighborhood Hits	29
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

ENAH_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.067802 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	784	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

ENAH_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.070746 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	919	Shared Neighborhood Hits	6
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

EVL_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.088508 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	260	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

EVL_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.084741 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	203	Shared Neighborhood Hits	7
SwissProt Accessions	P70429, Q9ERU8	Gene names	Evl
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

KRA94_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.061850 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	204	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BYQ2	Gene names	KRTAP9-4, KAP9.4, KRTAP9.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-4 (Keratin-associated protein 9.4) (Ultrahigh sulfur keratin-associated protein 9.4).

VASP_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.082206 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	201	Shared Neighborhood Hits	6
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

VASP_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.086809 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	195	Shared Neighborhood Hits	6
SwissProt Accessions	P70460, Q3TAP0, Q3TCD2, Q3U0C2, Q3UDF1, Q91VD2, Q9R214	Gene names	Vasp
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

Hits sorted by NC score

SPY2_HUMAN
NC score	0.999962 (rank : 1)	θ value	2.41524e-162 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	O43597, Q5T6Z7	Gene names	SPRY2
Domain Architecture
Description	Sprouty homolog 2 (Spry-2).

SPY2_MOUSE
NC score	0.996544 (rank : 2)	θ value	2.95243e-160 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	71	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QXV8, Q9WUQ9	Gene names	Spry2
Domain Architecture
Description	Sprouty homolog 2 (Spry-2).

SPY1_HUMAN
NC score	0.954425 (rank : 3)	θ value	2.47765e-74 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	64	Shared Neighborhood Hits	26
SwissProt Accessions	O43609, Q6PNE0	Gene names	SPRY1
Domain Architecture
Description	Sprouty homolog 1 (Spry-1).

SPY3_HUMAN
NC score	0.952233 (rank : 4)	θ value	7.73779e-60 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	48	Shared Neighborhood Hits	23
SwissProt Accessions	O43610	Gene names	SPRY3
Domain Architecture
Description	Sprouty homolog 3 (Spry-3).

SPY1_MOUSE
NC score	0.949069 (rank : 5)	θ value	9.43692e-66 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QXV9	Gene names	Spry1
Domain Architecture
Description	Sprouty homolog 1 (Spry-1).

SPY4_MOUSE
NC score	0.933341 (rank : 6)	θ value	2.75849e-49 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WTP2, Q9QXV7	Gene names	Spry4
Domain Architecture
Description	Sprouty homolog 4 (Spry-4).

SPY4_HUMAN
NC score	0.931070 (rank : 7)	θ value	8.87376e-48 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	38	Shared Neighborhood Hits	22
SwissProt Accessions	Q9C004, Q6QIX2, Q9C003	Gene names	SPRY4
Domain Architecture
Description	Sprouty homolog 4 (Spry-4).

SPRE3_HUMAN
NC score	0.534470 (rank : 8)	θ value	1.25267e-09 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q2MJR0	Gene names	SPRED3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

SPRE3_MOUSE
NC score	0.525775 (rank : 9)	θ value	1.25267e-09 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	Q6P6N5, Q7TNJ8	Gene names	Spred3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

SPRE1_HUMAN
NC score	0.520359 (rank : 10)	θ value	7.34386e-10 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	35	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z699, Q8N256	Gene names	SPRED1
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 1 (Spred-1).

SPRE1_MOUSE
NC score	0.518642 (rank : 11)	θ value	7.34386e-10 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	36	Shared Neighborhood Hits	15
SwissProt Accessions	Q924S8, Q6PET8	Gene names	Spred1
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 1 (Spred-1).

SPRE2_HUMAN
NC score	0.518198 (rank : 12)	θ value	2.13673e-09 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z698, Q2NKX6	Gene names	SPRED2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

SPRE2_MOUSE
NC score	0.514300 (rank : 13)	θ value	2.13673e-09 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	41	Shared Neighborhood Hits	14
SwissProt Accessions	Q924S7	Gene names	Spred2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

KRA92_HUMAN
NC score	0.125769 (rank : 14)	θ value	0.0148317 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

KR10B_HUMAN
NC score	0.108688 (rank : 15)	θ value	0.00298849 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	269	Shared Neighborhood Hits	32
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

KRA93_HUMAN
NC score	0.107539 (rank : 16)	θ value	0.0563607 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	203	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

KRA99_HUMAN
NC score	0.104594 (rank : 17)	θ value	0.125558 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	173	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYP9	Gene names	KRTAP9-9, KAP9.9, KRTAP9.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-9 (Keratin-associated protein 9.9) (Ultrahigh sulfur keratin-associated protein 9.9).

KRA98_HUMAN
NC score	0.103105 (rank : 18)	θ value	0.125558 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	185	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

EVL_HUMAN
NC score	0.088508 (rank : 19)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	66	Target Neighborhood Hits	260	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

VASP_MOUSE
NC score	0.086809 (rank : 20)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	66	Target Neighborhood Hits	195	Shared Neighborhood Hits	6
SwissProt Accessions	P70460, Q3TAP0, Q3TCD2, Q3U0C2, Q3UDF1, Q91VD2, Q9R214	Gene names	Vasp
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

EVL_MOUSE
NC score	0.084741 (rank : 21)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	66	Target Neighborhood Hits	203	Shared Neighborhood Hits	7
SwissProt Accessions	P70429, Q9ERU8	Gene names	Evl
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

VASP_HUMAN
NC score	0.082206 (rank : 22)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	66	Target Neighborhood Hits	201	Shared Neighborhood Hits	6
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

ENAH_MOUSE
NC score	0.070746 (rank : 23)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	66	Target Neighborhood Hits	919	Shared Neighborhood Hits	6
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

ENAH_HUMAN
NC score	0.067802 (rank : 24)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	66	Target Neighborhood Hits	784	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

KRA59_HUMAN
NC score	0.064985 (rank : 25)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	310	Shared Neighborhood Hits	32
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

KR511_HUMAN
NC score	0.063231 (rank : 26)	θ value	2.36792 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	231	Shared Neighborhood Hits	29
SwissProt Accessions	Q6L8G4	Gene names	KRTAP5-11, KAP5.11, KRTAP5.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-11 (Keratin-associated protein 5.11) (Ultrahigh sulfur keratin-associated protein 5.11).

SREC2_MOUSE
NC score	0.061958 (rank : 27)	θ value	1.06291 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	605	Shared Neighborhood Hits	40
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

KRA94_HUMAN
NC score	0.061850 (rank : 28)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	66	Target Neighborhood Hits	204	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BYQ2	Gene names	KRTAP9-4, KAP9.4, KRTAP9.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-4 (Keratin-associated protein 9.4) (Ultrahigh sulfur keratin-associated protein 9.4).

SREC2_HUMAN
NC score	0.056786 (rank : 29)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	645	Shared Neighborhood Hits	40
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

KRA53_HUMAN
NC score	0.055758 (rank : 30)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	331	Shared Neighborhood Hits	32
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KR107_HUMAN
NC score	0.052987 (rank : 31)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	330	Shared Neighborhood Hits	35
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

ITB3_MOUSE
NC score	0.049953 (rank : 32)	θ value	1.38821 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	319	Shared Neighborhood Hits	30
SwissProt Accessions	O54890	Gene names	Itgb3
Domain Architecture
Description	Integrin beta-3 precursor (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD61 antigen).

KR108_HUMAN
NC score	0.049898 (rank : 33)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	226	Shared Neighborhood Hits	23
SwissProt Accessions	P60410	Gene names	KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-8 (Keratin-associated protein 10.8) (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8).

ITB3_HUMAN
NC score	0.049332 (rank : 34)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	325	Shared Neighborhood Hits	31
SwissProt Accessions	P05106, O15495, Q13413, Q14648, Q16499	Gene names	ITGB3, GP3A
Domain Architecture
Description	Integrin beta-3 precursor (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD61 antigen).

MT4_MOUSE
NC score	0.046520 (rank : 35)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	102	Shared Neighborhood Hits	13
SwissProt Accessions	P47945	Gene names	Mt4
Domain Architecture	No domain graphic available
Description	Metallothionein-4 (MT-4) (Metallothionein-IV) (MT-IV).

LRP1B_HUMAN
NC score	0.044476 (rank : 36)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	602	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_MOUSE
NC score	0.043997 (rank : 37)	θ value	3.0926 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	606	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

MELPH_HUMAN
NC score	0.039959 (rank : 38)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	145	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

TRI42_MOUSE
NC score	0.039521 (rank : 39)	θ value	1.81305 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	316	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

LRP1_HUMAN
NC score	0.039421 (rank : 40)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	617	Shared Neighborhood Hits	39
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

TRI42_HUMAN
NC score	0.038949 (rank : 41)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	283	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

SSPO_MOUSE
NC score	0.038784 (rank : 42)	θ value	1.06291 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	800	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

MELPH_MOUSE
NC score	0.038774 (rank : 43)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	112	Shared Neighborhood Hits	4
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

LRP2_HUMAN
NC score	0.037874 (rank : 44)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	573	Shared Neighborhood Hits	38
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

JAG1_MOUSE
NC score	0.037790 (rank : 45)	θ value	3.0926 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	518	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

LAMC3_MOUSE
NC score	0.034729 (rank : 46)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	624	Shared Neighborhood Hits	33
SwissProt Accessions	Q9R0B6, Q9WTW6	Gene names	Lamc3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

JAG1_HUMAN
NC score	0.034384 (rank : 47)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	514	Shared Neighborhood Hits	38
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

LAMC3_HUMAN
NC score	0.033271 (rank : 48)	θ value	2.36792 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	588	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y6N6	Gene names	LAMC3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

NOTC4_MOUSE
NC score	0.033208 (rank : 49)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	872	Shared Neighborhood Hits	36
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

STAB2_HUMAN
NC score	0.032321 (rank : 50)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	534	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

FBN3_HUMAN
NC score	0.032024 (rank : 51)	θ value	0.62314 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	543	Shared Neighborhood Hits	34
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

NOTC1_MOUSE
NC score	0.029888 (rank : 52)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	916	Shared Neighborhood Hits	37
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

LTBP2_MOUSE
NC score	0.029803 (rank : 53)	θ value	2.36792 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	617	Shared Neighborhood Hits	31
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

FOXJ3_MOUSE
NC score	0.029025 (rank : 54)	θ value	0.125558 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BUR3, Q3UTD8	Gene names	Foxj3, Kiaa1041
Domain Architecture
Description	Forkhead box protein J3.

CORIN_MOUSE
NC score	0.027198 (rank : 55)	θ value	0.163984 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	451	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

USH2A_HUMAN
NC score	0.025467 (rank : 56)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	600	Shared Neighborhood Hits	29
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

FOXJ3_HUMAN
NC score	0.023841 (rank : 57)	θ value	0.365318 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	177	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UPW0, Q9NSS7	Gene names	FOXJ3, KIAA1041
Domain Architecture
Description	Forkhead box protein J3.

FBLN2_HUMAN
NC score	0.023678 (rank : 58)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	392	Shared Neighborhood Hits	26
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

REPS2_HUMAN
NC score	0.023029 (rank : 59)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	131	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

MUC13_MOUSE
NC score	0.022657 (rank : 60)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	447	Shared Neighborhood Hits	19
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

LY6H_HUMAN
NC score	0.020814 (rank : 61)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	O94772	Gene names	LY6H
Domain Architecture
Description	Lymphocyte antigen Ly-6H precursor.

EZH1_MOUSE
NC score	0.019280 (rank : 62)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	126	Shared Neighborhood Hits	16
SwissProt Accessions	P70351, Q9R089	Gene names	Ezh1, Enx2
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

KAZD1_HUMAN
NC score	0.018819 (rank : 63)	θ value	3.0926 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	248	Shared Neighborhood Hits	6
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

EZH1_HUMAN
NC score	0.016673 (rank : 64)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	121	Shared Neighborhood Hits	16
SwissProt Accessions	Q92800, O43287, Q14459	Gene names	EZH1, KIAA0388
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

FZD1_HUMAN
NC score	0.015108 (rank : 65)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UP38, O94815, Q549T8	Gene names	FZD1
Domain Architecture
Description	Frizzled-1 precursor (Fz-1) (hFz1) (FzE1).

FBX41_MOUSE
NC score	0.012519 (rank : 66)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	430	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NS60, Q6P7W4, Q6ZPG1	Gene names	Fbxo41, D6Ertd538e, Kiaa1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

JHD3A_HUMAN
NC score	0.011671 (rank : 67)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	O75164, Q5VVB1	Gene names	JMJD2A, JHDM3A, JMJD2, KIAA0677
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3A (EC 1.14.11.-) (Jumonji domain-containing protein 2A).

SI1L1_MOUSE
NC score	0.005144 (rank : 68)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	189	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

MCR_MOUSE
NC score	0.004930 (rank : 69)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	162	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

MCR_HUMAN
NC score	0.004921 (rank : 70)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	149	Shared Neighborhood Hits	4
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

ZNF12_HUMAN
NC score	-0.000588 (rank : 71)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	779	Shared Neighborhood Hits	5
SwissProt Accessions	P17014, Q9ULZ6	Gene names	ZNF12, GIOT3, KOX3, ZNF325
Domain Architecture	No domain graphic available
Description	Zinc finger protein 12 (Zinc finger protein KOX3) (Zinc finger protein 325) (Gonadotropin-inducible transcription repressor 3) (GIOT-3).

ZN234_HUMAN
NC score	-0.001072 (rank : 72)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	785	Shared Neighborhood Hits	5
SwissProt Accessions	Q14588, Q96IR4, Q9NS45, Q9NYT7	Gene names	ZNF234, ZNF269
Domain Architecture	No domain graphic available
Description	Zinc finger protein 234 (Zinc finger protein HZF4).

ZFP13_MOUSE
NC score	-0.001240 (rank : 73)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	771	Shared Neighborhood Hits	4
SwissProt Accessions	P10754, Q80WS0, Q8CDD0	Gene names	Zfp13, Krox-8, Zfp-13
Domain Architecture	No domain graphic available
Description	Zinc finger protein 13 (Zfp-13) (Krox-8 protein).