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Network neighborhood for query Sequence : SPY4_HUMAN

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SPY4_HUMAN
SwissProt Accessions	Q9C004, Q6QIX2, Q9C003	Gene names	SPRY4
Domain Architecture
Description	Sprouty homolog 4 (Spry-4).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SPY4_HUMAN
θ value	3.1544e-162 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	38	Target Neighborhood Hits	38	Shared Neighborhood Hits	38
SwissProt Accessions	Q9C004, Q6QIX2, Q9C003	Gene names	SPRY4
Domain Architecture
Description	Sprouty homolog 4 (Spry-4).

SPY4_MOUSE
θ value	3.61748e-150 (rank : 2)	NC score	0.997043 (rank : 2)
Query Neighborhood Hits	38	Target Neighborhood Hits	47	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WTP2, Q9QXV7	Gene names	Spry4
Domain Architecture
Description	Sprouty homolog 4 (Spry-4).

SPY3_HUMAN
θ value	2.57589e-55 (rank : 3)	NC score	0.951577 (rank : 3)
Query Neighborhood Hits	38	Target Neighborhood Hits	48	Shared Neighborhood Hits	19
SwissProt Accessions	O43610	Gene names	SPRY3
Domain Architecture
Description	Sprouty homolog 3 (Spry-3).

SPY1_HUMAN
θ value	1.66964e-54 (rank : 4)	NC score	0.937281 (rank : 4)
Query Neighborhood Hits	38	Target Neighborhood Hits	64	Shared Neighborhood Hits	20
SwissProt Accessions	O43609, Q6PNE0	Gene names	SPRY1
Domain Architecture
Description	Sprouty homolog 1 (Spry-1).

SPY1_MOUSE
θ value	6.56568e-51 (rank : 5)	NC score	0.934496 (rank : 5)
Query Neighborhood Hits	38	Target Neighborhood Hits	57	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QXV9	Gene names	Spry1
Domain Architecture
Description	Sprouty homolog 1 (Spry-1).

SPY2_MOUSE
θ value	5.20228e-48 (rank : 6)	NC score	0.929732 (rank : 7)
Query Neighborhood Hits	38	Target Neighborhood Hits	71	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXV8, Q9WUQ9	Gene names	Spry2
Domain Architecture
Description	Sprouty homolog 2 (Spry-2).

SPY2_HUMAN
θ value	8.87376e-48 (rank : 7)	NC score	0.931070 (rank : 6)
Query Neighborhood Hits	38	Target Neighborhood Hits	66	Shared Neighborhood Hits	22
SwissProt Accessions	O43597, Q5T6Z7	Gene names	SPRY2
Domain Architecture
Description	Sprouty homolog 2 (Spry-2).

SPRE2_HUMAN
θ value	1.80886e-08 (rank : 8)	NC score	0.499778 (rank : 10)
Query Neighborhood Hits	38	Target Neighborhood Hits	30	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z698, Q2NKX6	Gene names	SPRED2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

SPRE2_MOUSE
θ value	4.0297e-08 (rank : 9)	NC score	0.494391 (rank : 13)
Query Neighborhood Hits	38	Target Neighborhood Hits	41	Shared Neighborhood Hits	13
SwissProt Accessions	Q924S7	Gene names	Spred2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

SPRE1_HUMAN
θ value	6.87365e-08 (rank : 10)	NC score	0.498975 (rank : 11)
Query Neighborhood Hits	38	Target Neighborhood Hits	35	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z699, Q8N256	Gene names	SPRED1
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 1 (Spred-1).

SPRE1_MOUSE
θ value	6.87365e-08 (rank : 11)	NC score	0.496784 (rank : 12)
Query Neighborhood Hits	38	Target Neighborhood Hits	36	Shared Neighborhood Hits	13
SwissProt Accessions	Q924S8, Q6PET8	Gene names	Spred1
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 1 (Spred-1).

SPRE3_HUMAN
θ value	2.61198e-07 (rank : 12)	NC score	0.511676 (rank : 8)
Query Neighborhood Hits	38	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q2MJR0	Gene names	SPRED3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

SPRE3_MOUSE
θ value	2.61198e-07 (rank : 13)	NC score	0.503147 (rank : 9)
Query Neighborhood Hits	38	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	Q6P6N5, Q7TNJ8	Gene names	Spred3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

KR10B_HUMAN
θ value	0.21417 (rank : 14)	NC score	0.081863 (rank : 14)
Query Neighborhood Hits	38	Target Neighborhood Hits	269	Shared Neighborhood Hits	22
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

LRP1B_MOUSE
θ value	0.21417 (rank : 15)	NC score	0.041914 (rank : 24)
Query Neighborhood Hits	38	Target Neighborhood Hits	606	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_HUMAN
θ value	0.279714 (rank : 16)	NC score	0.041847 (rank : 25)
Query Neighborhood Hits	38	Target Neighborhood Hits	602	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

ITB2_MOUSE
θ value	0.47712 (rank : 17)	NC score	0.049149 (rank : 23)
Query Neighborhood Hits	38	Target Neighborhood Hits	326	Shared Neighborhood Hits	25
SwissProt Accessions	P11835, Q64482	Gene names	Itgb2
Domain Architecture
Description	Integrin beta-2 precursor (Cell surface adhesion glycoproteins LFA- 1/CR3/P150,95 subunit beta) (Complement receptor C3 subunit beta) (CD18 antigen).

NOTC4_HUMAN
θ value	0.47712 (rank : 18)	NC score	0.034859 (rank : 29)
Query Neighborhood Hits	38	Target Neighborhood Hits	905	Shared Neighborhood Hits	26
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

MTR1L_HUMAN
θ value	0.813845 (rank : 19)	NC score	0.004617 (rank : 46)
Query Neighborhood Hits	38	Target Neighborhood Hits	1180	Shared Neighborhood Hits	3
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

ZAN_HUMAN
θ value	1.06291 (rank : 20)	NC score	0.036898 (rank : 26)
Query Neighborhood Hits	38	Target Neighborhood Hits	679	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

TSP4_HUMAN
θ value	1.38821 (rank : 21)	NC score	0.034898 (rank : 28)
Query Neighborhood Hits	38	Target Neighborhood Hits	277	Shared Neighborhood Hits	21
SwissProt Accessions	P35443, Q86TG2	Gene names	THBS4, TSP4
Domain Architecture
Description	Thrombospondin-4 precursor.

ITB8_HUMAN
θ value	1.81305 (rank : 22)	NC score	0.032228 (rank : 35)
Query Neighborhood Hits	38	Target Neighborhood Hits	280	Shared Neighborhood Hits	21
SwissProt Accessions	P26012	Gene names	ITGB8
Domain Architecture
Description	Integrin beta-8 precursor.

NOTC3_HUMAN
θ value	1.81305 (rank : 23)	NC score	0.032241 (rank : 34)
Query Neighborhood Hits	38	Target Neighborhood Hits	1062	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

STAB2_HUMAN
θ value	1.81305 (rank : 24)	NC score	0.033210 (rank : 31)
Query Neighborhood Hits	38	Target Neighborhood Hits	534	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

JAG1_MOUSE
θ value	3.0926 (rank : 25)	NC score	0.036108 (rank : 27)
Query Neighborhood Hits	38	Target Neighborhood Hits	518	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

NOTC1_MOUSE
θ value	3.0926 (rank : 26)	NC score	0.030179 (rank : 37)
Query Neighborhood Hits	38	Target Neighborhood Hits	916	Shared Neighborhood Hits	23
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

VEGFC_MOUSE
θ value	5.27518 (rank : 27)	NC score	0.023344 (rank : 40)
Query Neighborhood Hits	38	Target Neighborhood Hits	119	Shared Neighborhood Hits	11
SwissProt Accessions	P97953, Q543R6	Gene names	Vegfc
Domain Architecture
Description	Vascular endothelial growth factor C precursor (VEGF-C) (Vascular endothelial growth factor-related protein) (VRP) (Flt4 ligand) (Flt4- L).

JAG1_HUMAN
θ value	6.88961 (rank : 28)	NC score	0.033463 (rank : 30)
Query Neighborhood Hits	38	Target Neighborhood Hits	514	Shared Neighborhood Hits	27
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

LAMA2_MOUSE
θ value	6.88961 (rank : 29)	NC score	0.021066 (rank : 42)
Query Neighborhood Hits	38	Target Neighborhood Hits	1198	Shared Neighborhood Hits	23
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

MEGF6_HUMAN
θ value	6.88961 (rank : 30)	NC score	0.025146 (rank : 39)
Query Neighborhood Hits	38	Target Neighborhood Hits	671	Shared Neighborhood Hits	22
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

MYRIP_MOUSE
θ value	6.88961 (rank : 31)	NC score	0.019982 (rank : 43)
Query Neighborhood Hits	38	Target Neighborhood Hits	207	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

NOTC3_MOUSE
θ value	6.88961 (rank : 32)	NC score	0.033154 (rank : 32)
Query Neighborhood Hits	38	Target Neighborhood Hits	975	Shared Neighborhood Hits	26
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

POLK_MOUSE
θ value	6.88961 (rank : 33)	NC score	0.011215 (rank : 45)
Query Neighborhood Hits	38	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QUG2, Q7TPY7	Gene names	Polk, Dinb1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).

SSPO_MOUSE
θ value	6.88961 (rank : 34)	NC score	0.030001 (rank : 38)
Query Neighborhood Hits	38	Target Neighborhood Hits	800	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

DLK_MOUSE
θ value	8.99809 (rank : 35)	NC score	0.030775 (rank : 36)
Query Neighborhood Hits	38	Target Neighborhood Hits	374	Shared Neighborhood Hits	22
SwissProt Accessions	Q09163, Q07645, Q62208	Gene names	Dlk1, Dlk, Pref1, Scp-1
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (Preadipocyte factor 1) (Pref-1) (Adipocyte differentiation inhibitor protein) [Contains: Fetal antigen 1 (FA1)].

LAMA2_HUMAN
θ value	8.99809 (rank : 36)	NC score	0.022659 (rank : 41)
Query Neighborhood Hits	38	Target Neighborhood Hits	1092	Shared Neighborhood Hits	23
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

MYRIP_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.018057 (rank : 44)
Query Neighborhood Hits	38	Target Neighborhood Hits	269	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

NOTC4_MOUSE
θ value	8.99809 (rank : 38)	NC score	0.032267 (rank : 33)
Query Neighborhood Hits	38	Target Neighborhood Hits	872	Shared Neighborhood Hits	25
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

ENAH_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.062657 (rank : 21)
Query Neighborhood Hits	38	Target Neighborhood Hits	784	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

ENAH_MOUSE
θ value	θ > 10 (rank : 40)	NC score	0.065988 (rank : 20)
Query Neighborhood Hits	38	Target Neighborhood Hits	919	Shared Neighborhood Hits	8
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

EVL_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.081484 (rank : 15)
Query Neighborhood Hits	38	Target Neighborhood Hits	260	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

EVL_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.077820 (rank : 17)
Query Neighborhood Hits	38	Target Neighborhood Hits	203	Shared Neighborhood Hits	6
SwissProt Accessions	P70429, Q9ERU8	Gene names	Evl
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

KRA59_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.053963 (rank : 22)
Query Neighborhood Hits	38	Target Neighborhood Hits	310	Shared Neighborhood Hits	25
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

KRA92_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.071974 (rank : 19)
Query Neighborhood Hits	38	Target Neighborhood Hits	198	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

VASP_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.076081 (rank : 18)
Query Neighborhood Hits	38	Target Neighborhood Hits	201	Shared Neighborhood Hits	6
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

VASP_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.080210 (rank : 16)
Query Neighborhood Hits	38	Target Neighborhood Hits	195	Shared Neighborhood Hits	6
SwissProt Accessions	P70460, Q3TAP0, Q3TCD2, Q3U0C2, Q3UDF1, Q91VD2, Q9R214	Gene names	Vasp
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

Hits sorted by NC score

SPY4_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.1544e-162 (rank : 1)
Query Neighborhood Hits	38	Target Neighborhood Hits	38	Shared Neighborhood Hits	38
SwissProt Accessions	Q9C004, Q6QIX2, Q9C003	Gene names	SPRY4
Domain Architecture
Description	Sprouty homolog 4 (Spry-4).

SPY4_MOUSE
NC score	0.997043 (rank : 2)	θ value	3.61748e-150 (rank : 2)
Query Neighborhood Hits	38	Target Neighborhood Hits	47	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WTP2, Q9QXV7	Gene names	Spry4
Domain Architecture
Description	Sprouty homolog 4 (Spry-4).

SPY3_HUMAN
NC score	0.951577 (rank : 3)	θ value	2.57589e-55 (rank : 3)
Query Neighborhood Hits	38	Target Neighborhood Hits	48	Shared Neighborhood Hits	19
SwissProt Accessions	O43610	Gene names	SPRY3
Domain Architecture
Description	Sprouty homolog 3 (Spry-3).

SPY1_HUMAN
NC score	0.937281 (rank : 4)	θ value	1.66964e-54 (rank : 4)
Query Neighborhood Hits	38	Target Neighborhood Hits	64	Shared Neighborhood Hits	20
SwissProt Accessions	O43609, Q6PNE0	Gene names	SPRY1
Domain Architecture
Description	Sprouty homolog 1 (Spry-1).

SPY1_MOUSE
NC score	0.934496 (rank : 5)	θ value	6.56568e-51 (rank : 5)
Query Neighborhood Hits	38	Target Neighborhood Hits	57	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QXV9	Gene names	Spry1
Domain Architecture
Description	Sprouty homolog 1 (Spry-1).

SPY2_HUMAN
NC score	0.931070 (rank : 6)	θ value	8.87376e-48 (rank : 7)
Query Neighborhood Hits	38	Target Neighborhood Hits	66	Shared Neighborhood Hits	22
SwissProt Accessions	O43597, Q5T6Z7	Gene names	SPRY2
Domain Architecture
Description	Sprouty homolog 2 (Spry-2).

SPY2_MOUSE
NC score	0.929732 (rank : 7)	θ value	5.20228e-48 (rank : 6)
Query Neighborhood Hits	38	Target Neighborhood Hits	71	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXV8, Q9WUQ9	Gene names	Spry2
Domain Architecture
Description	Sprouty homolog 2 (Spry-2).

SPRE3_HUMAN
NC score	0.511676 (rank : 8)	θ value	2.61198e-07 (rank : 12)
Query Neighborhood Hits	38	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q2MJR0	Gene names	SPRED3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

SPRE3_MOUSE
NC score	0.503147 (rank : 9)	θ value	2.61198e-07 (rank : 13)
Query Neighborhood Hits	38	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	Q6P6N5, Q7TNJ8	Gene names	Spred3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

SPRE2_HUMAN
NC score	0.499778 (rank : 10)	θ value	1.80886e-08 (rank : 8)
Query Neighborhood Hits	38	Target Neighborhood Hits	30	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z698, Q2NKX6	Gene names	SPRED2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

SPRE1_HUMAN
NC score	0.498975 (rank : 11)	θ value	6.87365e-08 (rank : 10)
Query Neighborhood Hits	38	Target Neighborhood Hits	35	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z699, Q8N256	Gene names	SPRED1
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 1 (Spred-1).

SPRE1_MOUSE
NC score	0.496784 (rank : 12)	θ value	6.87365e-08 (rank : 11)
Query Neighborhood Hits	38	Target Neighborhood Hits	36	Shared Neighborhood Hits	13
SwissProt Accessions	Q924S8, Q6PET8	Gene names	Spred1
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 1 (Spred-1).

SPRE2_MOUSE
NC score	0.494391 (rank : 13)	θ value	4.0297e-08 (rank : 9)
Query Neighborhood Hits	38	Target Neighborhood Hits	41	Shared Neighborhood Hits	13
SwissProt Accessions	Q924S7	Gene names	Spred2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

KR10B_HUMAN
NC score	0.081863 (rank : 14)	θ value	0.21417 (rank : 14)
Query Neighborhood Hits	38	Target Neighborhood Hits	269	Shared Neighborhood Hits	22
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

EVL_HUMAN
NC score	0.081484 (rank : 15)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	38	Target Neighborhood Hits	260	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

VASP_MOUSE
NC score	0.080210 (rank : 16)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	38	Target Neighborhood Hits	195	Shared Neighborhood Hits	6
SwissProt Accessions	P70460, Q3TAP0, Q3TCD2, Q3U0C2, Q3UDF1, Q91VD2, Q9R214	Gene names	Vasp
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

EVL_MOUSE
NC score	0.077820 (rank : 17)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	38	Target Neighborhood Hits	203	Shared Neighborhood Hits	6
SwissProt Accessions	P70429, Q9ERU8	Gene names	Evl
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

VASP_HUMAN
NC score	0.076081 (rank : 18)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	38	Target Neighborhood Hits	201	Shared Neighborhood Hits	6
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

KRA92_HUMAN
NC score	0.071974 (rank : 19)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	38	Target Neighborhood Hits	198	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

ENAH_MOUSE
NC score	0.065988 (rank : 20)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	38	Target Neighborhood Hits	919	Shared Neighborhood Hits	8
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

ENAH_HUMAN
NC score	0.062657 (rank : 21)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	38	Target Neighborhood Hits	784	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

KRA59_HUMAN
NC score	0.053963 (rank : 22)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	38	Target Neighborhood Hits	310	Shared Neighborhood Hits	25
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

ITB2_MOUSE
NC score	0.049149 (rank : 23)	θ value	0.47712 (rank : 17)
Query Neighborhood Hits	38	Target Neighborhood Hits	326	Shared Neighborhood Hits	25
SwissProt Accessions	P11835, Q64482	Gene names	Itgb2
Domain Architecture
Description	Integrin beta-2 precursor (Cell surface adhesion glycoproteins LFA- 1/CR3/P150,95 subunit beta) (Complement receptor C3 subunit beta) (CD18 antigen).

LRP1B_MOUSE
NC score	0.041914 (rank : 24)	θ value	0.21417 (rank : 15)
Query Neighborhood Hits	38	Target Neighborhood Hits	606	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_HUMAN
NC score	0.041847 (rank : 25)	θ value	0.279714 (rank : 16)
Query Neighborhood Hits	38	Target Neighborhood Hits	602	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

ZAN_HUMAN
NC score	0.036898 (rank : 26)	θ value	1.06291 (rank : 20)
Query Neighborhood Hits	38	Target Neighborhood Hits	679	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

JAG1_MOUSE
NC score	0.036108 (rank : 27)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	38	Target Neighborhood Hits	518	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

TSP4_HUMAN
NC score	0.034898 (rank : 28)	θ value	1.38821 (rank : 21)
Query Neighborhood Hits	38	Target Neighborhood Hits	277	Shared Neighborhood Hits	21
SwissProt Accessions	P35443, Q86TG2	Gene names	THBS4, TSP4
Domain Architecture
Description	Thrombospondin-4 precursor.

NOTC4_HUMAN
NC score	0.034859 (rank : 29)	θ value	0.47712 (rank : 18)
Query Neighborhood Hits	38	Target Neighborhood Hits	905	Shared Neighborhood Hits	26
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

JAG1_HUMAN
NC score	0.033463 (rank : 30)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	38	Target Neighborhood Hits	514	Shared Neighborhood Hits	27
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

STAB2_HUMAN
NC score	0.033210 (rank : 31)	θ value	1.81305 (rank : 24)
Query Neighborhood Hits	38	Target Neighborhood Hits	534	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

NOTC3_MOUSE
NC score	0.033154 (rank : 32)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	38	Target Neighborhood Hits	975	Shared Neighborhood Hits	26
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC4_MOUSE
NC score	0.032267 (rank : 33)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	38	Target Neighborhood Hits	872	Shared Neighborhood Hits	25
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

NOTC3_HUMAN
NC score	0.032241 (rank : 34)	θ value	1.81305 (rank : 23)
Query Neighborhood Hits	38	Target Neighborhood Hits	1062	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

ITB8_HUMAN
NC score	0.032228 (rank : 35)	θ value	1.81305 (rank : 22)
Query Neighborhood Hits	38	Target Neighborhood Hits	280	Shared Neighborhood Hits	21
SwissProt Accessions	P26012	Gene names	ITGB8
Domain Architecture
Description	Integrin beta-8 precursor.

DLK_MOUSE
NC score	0.030775 (rank : 36)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	38	Target Neighborhood Hits	374	Shared Neighborhood Hits	22
SwissProt Accessions	Q09163, Q07645, Q62208	Gene names	Dlk1, Dlk, Pref1, Scp-1
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (Preadipocyte factor 1) (Pref-1) (Adipocyte differentiation inhibitor protein) [Contains: Fetal antigen 1 (FA1)].

NOTC1_MOUSE
NC score	0.030179 (rank : 37)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	38	Target Neighborhood Hits	916	Shared Neighborhood Hits	23
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

SSPO_MOUSE
NC score	0.030001 (rank : 38)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	38	Target Neighborhood Hits	800	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

MEGF6_HUMAN
NC score	0.025146 (rank : 39)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	38	Target Neighborhood Hits	671	Shared Neighborhood Hits	22
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

VEGFC_MOUSE
NC score	0.023344 (rank : 40)	θ value	5.27518 (rank : 27)
Query Neighborhood Hits	38	Target Neighborhood Hits	119	Shared Neighborhood Hits	11
SwissProt Accessions	P97953, Q543R6	Gene names	Vegfc
Domain Architecture
Description	Vascular endothelial growth factor C precursor (VEGF-C) (Vascular endothelial growth factor-related protein) (VRP) (Flt4 ligand) (Flt4- L).

LAMA2_HUMAN
NC score	0.022659 (rank : 41)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	38	Target Neighborhood Hits	1092	Shared Neighborhood Hits	23
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

LAMA2_MOUSE
NC score	0.021066 (rank : 42)	θ value	6.88961 (rank : 29)
Query Neighborhood Hits	38	Target Neighborhood Hits	1198	Shared Neighborhood Hits	23
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

MYRIP_MOUSE
NC score	0.019982 (rank : 43)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	38	Target Neighborhood Hits	207	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

MYRIP_HUMAN
NC score	0.018057 (rank : 44)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	38	Target Neighborhood Hits	269	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

POLK_MOUSE
NC score	0.011215 (rank : 45)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	38	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QUG2, Q7TPY7	Gene names	Polk, Dinb1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).

MTR1L_HUMAN
NC score	0.004617 (rank : 46)	θ value	0.813845 (rank : 19)
Query Neighborhood Hits	38	Target Neighborhood Hits	1180	Shared Neighborhood Hits	3
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).