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Network neighborhood for query Sequence : POLK_MOUSE

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POLK_MOUSE
SwissProt Accessions	Q9QUG2, Q7TPY7	Gene names	Polk, Dinb1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

POLK_HUMAN
θ value	0 (rank : 1)	NC score	0.985975 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	64	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UBT6, Q86VJ8, Q8IZY0, Q8IZY1, Q8NB30, Q96L01, Q96Q86, Q96Q87, Q9UHC5	Gene names	POLK, DINB1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).

POLK_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QUG2, Q7TPY7	Gene names	Polk, Dinb1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).

POLI_MOUSE
θ value	1.79631e-32 (rank : 3)	NC score	0.742718 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	Q6R3M4, Q641P1, Q6R3M3, Q9R1A6	Gene names	Poli, Rad30b
Domain Architecture	No domain graphic available
Description	DNA polymerase iota (EC 2.7.7.7) (Rad30 homolog B).

POLI_HUMAN
θ value	9.8567e-31 (rank : 4)	NC score	0.737770 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	28	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UNA4, Q8N590, Q9H0S1, Q9NYH6	Gene names	POLI, RAD30B
Domain Architecture	No domain graphic available
Description	DNA polymerase iota (EC 2.7.7.7) (RAD30 homolog B) (Eta2).

POLH_MOUSE
θ value	2.77775e-25 (rank : 5)	NC score	0.690122 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	29	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JJN0, Q9JJJ2	Gene names	Polh, Rad30a, Xpv
Domain Architecture	No domain graphic available
Description	DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein homolog).

POLH_HUMAN
θ value	5.79196e-23 (rank : 6)	NC score	0.681310 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	44	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y253, Q7L8E3, Q96BC4, Q9BX13	Gene names	POLH, RAD30, RAD30A, XPV
Domain Architecture	No domain graphic available
Description	DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein).

REV1_HUMAN
θ value	2.43343e-21 (rank : 7)	NC score	0.600833 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UBZ9, O95941, Q9C0J4, Q9NUP2	Gene names	REV1L, REV1
Domain Architecture	No domain graphic available
Description	DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase) (Alpha integrin-binding protein 80) (AIBP80).

REV1_MOUSE
θ value	1.5773e-20 (rank : 8)	NC score	0.579750 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	67	Shared Neighborhood Hits	9
SwissProt Accessions	Q920Q2, Q9QXV2	Gene names	Rev1l, Rev1
Domain Architecture	No domain graphic available
Description	DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase).

DMP1_MOUSE
θ value	0.0252991 (rank : 9)	NC score	0.054980 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	498	Shared Neighborhood Hits	13
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

HIP1_HUMAN
θ value	0.163984 (rank : 10)	NC score	0.035859 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	1016	Shared Neighborhood Hits	26
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

HRX_HUMAN
θ value	0.279714 (rank : 11)	NC score	0.030011 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	825	Shared Neighborhood Hits	11
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

NIN_HUMAN
θ value	0.279714 (rank : 12)	NC score	0.034324 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	1416	Shared Neighborhood Hits	27
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

RAD50_HUMAN
θ value	0.62314 (rank : 13)	NC score	0.036914 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	1317	Shared Neighborhood Hits	29
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

CTRO_HUMAN
θ value	0.813845 (rank : 14)	NC score	0.012845 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	2092	Shared Neighborhood Hits	29
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

MRCKB_HUMAN
θ value	0.813845 (rank : 15)	NC score	0.014490 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	2239	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PLEC1_HUMAN
θ value	1.06291 (rank : 16)	NC score	0.022715 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	1326	Shared Neighborhood Hits	26
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

BRCA2_HUMAN
θ value	1.38821 (rank : 17)	NC score	0.029134 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	202	Shared Neighborhood Hits	8
SwissProt Accessions	P51587, O00183, O15008, Q13879	Gene names	BRCA2, FANCD1
Domain Architecture
Description	Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein).

TRIPC_HUMAN
θ value	1.38821 (rank : 18)	NC score	0.018861 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	319	Shared Neighborhood Hits	5
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

CTNL1_MOUSE
θ value	1.81305 (rank : 19)	NC score	0.023383 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	91	Shared Neighborhood Hits	7
SwissProt Accessions	O88327, Q810J3	Gene names	Ctnnal1, Catnal1
Domain Architecture	No domain graphic available
Description	Alpha-catulin (Catenin alpha-like protein 1) (Alpha-catenin-related protein) (ACRP).

IL12A_HUMAN
θ value	1.81305 (rank : 20)	NC score	0.039416 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	P29459, Q96QZ1	Gene names	IL12A, NKSF1
Domain Architecture
Description	Interleukin-12 alpha chain precursor (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (NK cell stimulatory factor chain 1) (NKSF1).

SACS_MOUSE
θ value	1.81305 (rank : 21)	NC score	0.035840 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLC8	Gene names	Sacs
Domain Architecture
Description	Sacsin.

CLMN_MOUSE
θ value	2.36792 (rank : 22)	NC score	0.017573 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	180	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

DSPP_HUMAN
θ value	2.36792 (rank : 23)	NC score	0.022648 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	645	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

DSPP_MOUSE
θ value	2.36792 (rank : 24)	NC score	0.026359 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	491	Shared Neighborhood Hits	6
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

FYCO1_HUMAN
θ value	2.36792 (rank : 25)	NC score	0.023354 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	1149	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

GCC2_HUMAN
θ value	2.36792 (rank : 26)	NC score	0.027522 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	1558	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

RBP24_HUMAN
θ value	2.36792 (rank : 27)	NC score	0.027583 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	1559	Shared Neighborhood Hits	30
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

SACS_HUMAN
θ value	2.36792 (rank : 28)	NC score	0.034844 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	128	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZJ4, O94835	Gene names	SACS, KIAA0730
Domain Architecture
Description	Sacsin.

TS13_MOUSE
θ value	2.36792 (rank : 29)	NC score	0.033779 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	191	Shared Neighborhood Hits	3
SwissProt Accessions	Q01755	Gene names	Tcp11
Domain Architecture
Description	Testis-specific protein PBS13.

FLIP1_MOUSE
θ value	3.0926 (rank : 30)	NC score	0.029674 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	1176	Shared Neighborhood Hits	25
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GOGA4_HUMAN
θ value	3.0926 (rank : 31)	NC score	0.020914 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	2034	Shared Neighborhood Hits	31
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

ROCK2_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.011876 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	2073	Shared Neighborhood Hits	27
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

ADDG_MOUSE
θ value	4.03905 (rank : 33)	NC score	0.019241 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QYB5, Q9D2M5, Q9QYB6	Gene names	Add3, Addl
Domain Architecture
Description	Gamma-adducin (Adducin-like protein 70).

ERCC5_MOUSE
θ value	4.03905 (rank : 34)	NC score	0.038009 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	206	Shared Neighborhood Hits	9
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

KIF5C_HUMAN
θ value	4.03905 (rank : 35)	NC score	0.014532 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	974	Shared Neighborhood Hits	26
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

NEUL_HUMAN
θ value	4.03905 (rank : 36)	NC score	0.020539 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYT8, Q9ULJ4	Gene names	NLN, KIAA1226
Domain Architecture
Description	Neurolysin, mitochondrial precursor (EC 3.4.24.16) (Neurotensin endopeptidase) (Mitochondrial oligopeptidase M) (Microsomal endopeptidase) (MEP).

ADDG_HUMAN
θ value	5.27518 (rank : 37)	NC score	0.017893 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UEY8, O43243, Q92773, Q9UEY7	Gene names	ADD3, ADDL
Domain Architecture
Description	Gamma-adducin (Adducin-like protein 70).

DAAM2_HUMAN
θ value	5.27518 (rank : 38)	NC score	0.012146 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	350	Shared Neighborhood Hits	14
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

GP158_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.018384 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	221	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T848, Q6QR81, Q9ULT3	Gene names	GPR158, KIAA1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

MAFB_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.018663 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	96	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5Q3, Q9H1F1	Gene names	MAFB, KRML
Domain Architecture
Description	Transcription factor MafB (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B).

MAFB_MOUSE
θ value	5.27518 (rank : 41)	NC score	0.018672 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	P54841	Gene names	Mafb, Krml, Maf1
Domain Architecture
Description	Transcription factor MafB (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B) (Transcription factor MAF1) (Segmentation protein KR) (Kreisler).

MDC1_HUMAN
θ value	5.27518 (rank : 42)	NC score	0.009974 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	1446	Shared Neighborhood Hits	13
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

REST_HUMAN
θ value	5.27518 (rank : 43)	NC score	0.018981 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	1605	Shared Neighborhood Hits	26
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

RUSC2_MOUSE
θ value	5.27518 (rank : 44)	NC score	0.017123 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	305	Shared Neighborhood Hits	3
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

AKAP2_MOUSE
θ value	6.88961 (rank : 45)	NC score	0.028820 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	385	Shared Neighborhood Hits	13
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

AMPH_HUMAN
θ value	6.88961 (rank : 46)	NC score	0.015992 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	455	Shared Neighborhood Hits	10
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

FV1_MOUSE
θ value	6.88961 (rank : 47)	NC score	0.024471 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	P70213, P70214	Gene names	Fv1
Domain Architecture	No domain graphic available
Description	Friend virus susceptibility protein 1.

GOGA3_MOUSE
θ value	6.88961 (rank : 48)	NC score	0.023313 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	1437	Shared Neighborhood Hits	28
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

KMHN1_HUMAN
θ value	6.88961 (rank : 49)	NC score	0.027185 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	950	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

L1CAM_MOUSE
θ value	6.88961 (rank : 50)	NC score	0.005644 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	457	Shared Neighborhood Hits	3
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

PRDM1_HUMAN
θ value	6.88961 (rank : 51)	NC score	-0.000976 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	734	Shared Neighborhood Hits	2
SwissProt Accessions	O75626	Gene names	PRDM1, BLIMP1
Domain Architecture
Description	PR domain zinc finger protein 1 (PR domain-containing protein 1) (Beta-interferon gene positive-regulatory domain I-binding factor) (BLIMP-1) (Positive regulatory domain I-binding factor 1) (PRDI- binding factor 1) (PRDI-BF1).

RPGF6_HUMAN
θ value	6.88961 (rank : 52)	NC score	0.008609 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	266	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

SCG1_HUMAN
θ value	6.88961 (rank : 53)	NC score	0.017524 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	156	Shared Neighborhood Hits	5
SwissProt Accessions	P05060, Q9BQV6, Q9UJA6	Gene names	CHGB, SCG1
Domain Architecture
Description	Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide].

SPY4_HUMAN
θ value	6.88961 (rank : 54)	NC score	0.011215 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	Q9C004, Q6QIX2, Q9C003	Gene names	SPRY4
Domain Architecture
Description	Sprouty homolog 4 (Spry-4).

SRPK2_MOUSE
θ value	6.88961 (rank : 55)	NC score	0.006684 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	765	Shared Neighborhood Hits	16
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

TPM1_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.031440 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	716	Shared Neighborhood Hits	24
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM1_MOUSE
θ value	6.88961 (rank : 57)	NC score	0.031363 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	729	Shared Neighborhood Hits	24
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

EME1_HUMAN
θ value	8.99809 (rank : 58)	NC score	0.013177 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q96AY2, Q96N62	Gene names	EME1, MMS4
Domain Architecture	No domain graphic available
Description	Crossover junction endonuclease EME1 (EC 3.1.22.-) (hMMS4).

FLIP1_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.023867 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	1405	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

IRK8_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.003977 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q15842, O00657	Gene names	KCNJ8
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1).

MACF1_MOUSE
θ value	8.99809 (rank : 61)	NC score	0.020835 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	1313	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

MDM4_HUMAN
θ value	8.99809 (rank : 62)	NC score	0.010831 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

RAD50_MOUSE
θ value	8.99809 (rank : 63)	NC score	0.031689 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	1366	Shared Neighborhood Hits	24
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

T23O_HUMAN
θ value	8.99809 (rank : 64)	NC score	0.021986 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	P48775	Gene names	TDO2, TDO
Domain Architecture
Description	Tryptophan 2,3-dioxygenase (EC 1.13.11.11) (TO) (Tryptophan pyrrolase) (Tryptophanase) (Tryptophan oxygenase) (Tryptamin 2,3-dioxygenase) (TRPO).

TEX2_HUMAN
θ value	8.99809 (rank : 65)	NC score	0.014583 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	106	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IWB9, Q6AHZ5, Q8N3L0, Q9C0C5	Gene names	TEX2, KIAA1738
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 2 protein.

TRI12_MOUSE
θ value	8.99809 (rank : 66)	NC score	0.004095 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	387	Shared Neighborhood Hits	7
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

Hits sorted by NC score

POLK_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QUG2, Q7TPY7	Gene names	Polk, Dinb1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).

POLK_HUMAN
NC score	0.985975 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	64	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UBT6, Q86VJ8, Q8IZY0, Q8IZY1, Q8NB30, Q96L01, Q96Q86, Q96Q87, Q9UHC5	Gene names	POLK, DINB1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).

POLI_MOUSE
NC score	0.742718 (rank : 3)	θ value	1.79631e-32 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	Q6R3M4, Q641P1, Q6R3M3, Q9R1A6	Gene names	Poli, Rad30b
Domain Architecture	No domain graphic available
Description	DNA polymerase iota (EC 2.7.7.7) (Rad30 homolog B).

POLI_HUMAN
NC score	0.737770 (rank : 4)	θ value	9.8567e-31 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	28	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UNA4, Q8N590, Q9H0S1, Q9NYH6	Gene names	POLI, RAD30B
Domain Architecture	No domain graphic available
Description	DNA polymerase iota (EC 2.7.7.7) (RAD30 homolog B) (Eta2).

POLH_MOUSE
NC score	0.690122 (rank : 5)	θ value	2.77775e-25 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	29	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JJN0, Q9JJJ2	Gene names	Polh, Rad30a, Xpv
Domain Architecture	No domain graphic available
Description	DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein homolog).

POLH_HUMAN
NC score	0.681310 (rank : 6)	θ value	5.79196e-23 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	44	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y253, Q7L8E3, Q96BC4, Q9BX13	Gene names	POLH, RAD30, RAD30A, XPV
Domain Architecture	No domain graphic available
Description	DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein).

REV1_HUMAN
NC score	0.600833 (rank : 7)	θ value	2.43343e-21 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UBZ9, O95941, Q9C0J4, Q9NUP2	Gene names	REV1L, REV1
Domain Architecture	No domain graphic available
Description	DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase) (Alpha integrin-binding protein 80) (AIBP80).

REV1_MOUSE
NC score	0.579750 (rank : 8)	θ value	1.5773e-20 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	67	Shared Neighborhood Hits	9
SwissProt Accessions	Q920Q2, Q9QXV2	Gene names	Rev1l, Rev1
Domain Architecture	No domain graphic available
Description	DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase).

DMP1_MOUSE
NC score	0.054980 (rank : 9)	θ value	0.0252991 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	498	Shared Neighborhood Hits	13
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

IL12A_HUMAN
NC score	0.039416 (rank : 10)	θ value	1.81305 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	P29459, Q96QZ1	Gene names	IL12A, NKSF1
Domain Architecture
Description	Interleukin-12 alpha chain precursor (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (NK cell stimulatory factor chain 1) (NKSF1).

ERCC5_MOUSE
NC score	0.038009 (rank : 11)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	206	Shared Neighborhood Hits	9
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

RAD50_HUMAN
NC score	0.036914 (rank : 12)	θ value	0.62314 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	1317	Shared Neighborhood Hits	29
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

HIP1_HUMAN
NC score	0.035859 (rank : 13)	θ value	0.163984 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	1016	Shared Neighborhood Hits	26
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

SACS_MOUSE
NC score	0.035840 (rank : 14)	θ value	1.81305 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLC8	Gene names	Sacs
Domain Architecture
Description	Sacsin.

SACS_HUMAN
NC score	0.034844 (rank : 15)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	128	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZJ4, O94835	Gene names	SACS, KIAA0730
Domain Architecture
Description	Sacsin.

NIN_HUMAN
NC score	0.034324 (rank : 16)	θ value	0.279714 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	1416	Shared Neighborhood Hits	27
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

TS13_MOUSE
NC score	0.033779 (rank : 17)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	191	Shared Neighborhood Hits	3
SwissProt Accessions	Q01755	Gene names	Tcp11
Domain Architecture
Description	Testis-specific protein PBS13.

RAD50_MOUSE
NC score	0.031689 (rank : 18)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	1366	Shared Neighborhood Hits	24
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

TPM1_HUMAN
NC score	0.031440 (rank : 19)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	716	Shared Neighborhood Hits	24
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM1_MOUSE
NC score	0.031363 (rank : 20)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	729	Shared Neighborhood Hits	24
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

HRX_HUMAN
NC score	0.030011 (rank : 21)	θ value	0.279714 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	825	Shared Neighborhood Hits	11
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

FLIP1_MOUSE
NC score	0.029674 (rank : 22)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	1176	Shared Neighborhood Hits	25
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

BRCA2_HUMAN
NC score	0.029134 (rank : 23)	θ value	1.38821 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	202	Shared Neighborhood Hits	8
SwissProt Accessions	P51587, O00183, O15008, Q13879	Gene names	BRCA2, FANCD1
Domain Architecture
Description	Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein).

AKAP2_MOUSE
NC score	0.028820 (rank : 24)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	385	Shared Neighborhood Hits	13
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

RBP24_HUMAN
NC score	0.027583 (rank : 25)	θ value	2.36792 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	1559	Shared Neighborhood Hits	30
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

GCC2_HUMAN
NC score	0.027522 (rank : 26)	θ value	2.36792 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	1558	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

KMHN1_HUMAN
NC score	0.027185 (rank : 27)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	950	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

DSPP_MOUSE
NC score	0.026359 (rank : 28)	θ value	2.36792 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	491	Shared Neighborhood Hits	6
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

FV1_MOUSE
NC score	0.024471 (rank : 29)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	P70213, P70214	Gene names	Fv1
Domain Architecture	No domain graphic available
Description	Friend virus susceptibility protein 1.

FLIP1_HUMAN
NC score	0.023867 (rank : 30)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	1405	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

CTNL1_MOUSE
NC score	0.023383 (rank : 31)	θ value	1.81305 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	91	Shared Neighborhood Hits	7
SwissProt Accessions	O88327, Q810J3	Gene names	Ctnnal1, Catnal1
Domain Architecture	No domain graphic available
Description	Alpha-catulin (Catenin alpha-like protein 1) (Alpha-catenin-related protein) (ACRP).

FYCO1_HUMAN
NC score	0.023354 (rank : 32)	θ value	2.36792 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	1149	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

GOGA3_MOUSE
NC score	0.023313 (rank : 33)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	1437	Shared Neighborhood Hits	28
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

PLEC1_HUMAN
NC score	0.022715 (rank : 34)	θ value	1.06291 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	1326	Shared Neighborhood Hits	26
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

DSPP_HUMAN
NC score	0.022648 (rank : 35)	θ value	2.36792 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	645	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

T23O_HUMAN
NC score	0.021986 (rank : 36)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	P48775	Gene names	TDO2, TDO
Domain Architecture
Description	Tryptophan 2,3-dioxygenase (EC 1.13.11.11) (TO) (Tryptophan pyrrolase) (Tryptophanase) (Tryptophan oxygenase) (Tryptamin 2,3-dioxygenase) (TRPO).

GOGA4_HUMAN
NC score	0.020914 (rank : 37)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	2034	Shared Neighborhood Hits	31
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

MACF1_MOUSE
NC score	0.020835 (rank : 38)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	1313	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

NEUL_HUMAN
NC score	0.020539 (rank : 39)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYT8, Q9ULJ4	Gene names	NLN, KIAA1226
Domain Architecture
Description	Neurolysin, mitochondrial precursor (EC 3.4.24.16) (Neurotensin endopeptidase) (Mitochondrial oligopeptidase M) (Microsomal endopeptidase) (MEP).

ADDG_MOUSE
NC score	0.019241 (rank : 40)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QYB5, Q9D2M5, Q9QYB6	Gene names	Add3, Addl
Domain Architecture
Description	Gamma-adducin (Adducin-like protein 70).

REST_HUMAN
NC score	0.018981 (rank : 41)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	1605	Shared Neighborhood Hits	26
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

TRIPC_HUMAN
NC score	0.018861 (rank : 42)	θ value	1.38821 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	319	Shared Neighborhood Hits	5
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

MAFB_MOUSE
NC score	0.018672 (rank : 43)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	P54841	Gene names	Mafb, Krml, Maf1
Domain Architecture
Description	Transcription factor MafB (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B) (Transcription factor MAF1) (Segmentation protein KR) (Kreisler).

MAFB_HUMAN
NC score	0.018663 (rank : 44)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	96	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5Q3, Q9H1F1	Gene names	MAFB, KRML
Domain Architecture
Description	Transcription factor MafB (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B).

GP158_HUMAN
NC score	0.018384 (rank : 45)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	221	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T848, Q6QR81, Q9ULT3	Gene names	GPR158, KIAA1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

ADDG_HUMAN
NC score	0.017893 (rank : 46)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UEY8, O43243, Q92773, Q9UEY7	Gene names	ADD3, ADDL
Domain Architecture
Description	Gamma-adducin (Adducin-like protein 70).

CLMN_MOUSE
NC score	0.017573 (rank : 47)	θ value	2.36792 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	180	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

SCG1_HUMAN
NC score	0.017524 (rank : 48)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	156	Shared Neighborhood Hits	5
SwissProt Accessions	P05060, Q9BQV6, Q9UJA6	Gene names	CHGB, SCG1
Domain Architecture
Description	Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide].

RUSC2_MOUSE
NC score	0.017123 (rank : 49)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	305	Shared Neighborhood Hits	3
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

AMPH_HUMAN
NC score	0.015992 (rank : 50)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	455	Shared Neighborhood Hits	10
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

TEX2_HUMAN
NC score	0.014583 (rank : 51)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	106	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IWB9, Q6AHZ5, Q8N3L0, Q9C0C5	Gene names	TEX2, KIAA1738
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 2 protein.

KIF5C_HUMAN
NC score	0.014532 (rank : 52)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	974	Shared Neighborhood Hits	26
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

MRCKB_HUMAN
NC score	0.014490 (rank : 53)	θ value	0.813845 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	2239	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

EME1_HUMAN
NC score	0.013177 (rank : 54)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q96AY2, Q96N62	Gene names	EME1, MMS4
Domain Architecture	No domain graphic available
Description	Crossover junction endonuclease EME1 (EC 3.1.22.-) (hMMS4).

CTRO_HUMAN
NC score	0.012845 (rank : 55)	θ value	0.813845 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	2092	Shared Neighborhood Hits	29
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

DAAM2_HUMAN
NC score	0.012146 (rank : 56)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	350	Shared Neighborhood Hits	14
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

ROCK2_HUMAN
NC score	0.011876 (rank : 57)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	2073	Shared Neighborhood Hits	27
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

SPY4_HUMAN
NC score	0.011215 (rank : 58)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	Q9C004, Q6QIX2, Q9C003	Gene names	SPRY4
Domain Architecture
Description	Sprouty homolog 4 (Spry-4).

MDM4_HUMAN
NC score	0.010831 (rank : 59)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MDC1_HUMAN
NC score	0.009974 (rank : 60)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	1446	Shared Neighborhood Hits	13
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

RPGF6_HUMAN
NC score	0.008609 (rank : 61)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	266	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

SRPK2_MOUSE
NC score	0.006684 (rank : 62)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	765	Shared Neighborhood Hits	16
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

L1CAM_MOUSE
NC score	0.005644 (rank : 63)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	457	Shared Neighborhood Hits	3
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

TRI12_MOUSE
NC score	0.004095 (rank : 64)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	387	Shared Neighborhood Hits	7
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

IRK8_HUMAN
NC score	0.003977 (rank : 65)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q15842, O00657	Gene names	KCNJ8
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1).

PRDM1_HUMAN
NC score	-0.000976 (rank : 66)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	734	Shared Neighborhood Hits	2
SwissProt Accessions	O75626	Gene names	PRDM1, BLIMP1
Domain Architecture
Description	PR domain zinc finger protein 1 (PR domain-containing protein 1) (Beta-interferon gene positive-regulatory domain I-binding factor) (BLIMP-1) (Positive regulatory domain I-binding factor 1) (PRDI- binding factor 1) (PRDI-BF1).