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Network neighborhood for query Sequence : MDM4_HUMAN

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MDM4_HUMAN
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MDM4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	37	Target Neighborhood Hits	37	Shared Neighborhood Hits	37
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MDM4_MOUSE
θ value	0 (rank : 2)	NC score	0.986345 (rank : 2)
Query Neighborhood Hits	37	Target Neighborhood Hits	36	Shared Neighborhood Hits	24
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MDM2_HUMAN
θ value	8.55514e-59 (rank : 3)	NC score	0.877328 (rank : 3)
Query Neighborhood Hits	37	Target Neighborhood Hits	92	Shared Neighborhood Hits	25
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

MDM2_MOUSE
θ value	3.36421e-55 (rank : 4)	NC score	0.875077 (rank : 4)
Query Neighborhood Hits	37	Target Neighborhood Hits	77	Shared Neighborhood Hits	23
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

BIRC2_MOUSE
θ value	0.00175202 (rank : 5)	NC score	0.201399 (rank : 11)
Query Neighborhood Hits	37	Target Neighborhood Hits	137	Shared Neighborhood Hits	25
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

NEURL_MOUSE
θ value	0.00175202 (rank : 6)	NC score	0.266864 (rank : 5)
Query Neighborhood Hits	37	Target Neighborhood Hits	106	Shared Neighborhood Hits	27
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

NEUL1_HUMAN
θ value	0.00228821 (rank : 7)	NC score	0.261744 (rank : 6)
Query Neighborhood Hits	37	Target Neighborhood Hits	114	Shared Neighborhood Hits	27
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

RNF12_HUMAN
θ value	0.00665767 (rank : 8)	NC score	0.114382 (rank : 23)
Query Neighborhood Hits	37	Target Neighborhood Hits	173	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NVW2, Q9Y598	Gene names	RNF12, RLIM
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (NY-REN-43 antigen).

BIRC2_HUMAN
θ value	0.00869519 (rank : 9)	NC score	0.182622 (rank : 14)
Query Neighborhood Hits	37	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC3_HUMAN
θ value	0.00869519 (rank : 10)	NC score	0.199577 (rank : 12)
Query Neighborhood Hits	37	Target Neighborhood Hits	133	Shared Neighborhood Hits	25
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

MIB1_HUMAN
θ value	0.00869519 (rank : 11)	NC score	0.083649 (rank : 31)
Query Neighborhood Hits	37	Target Neighborhood Hits	470	Shared Neighborhood Hits	25
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
θ value	0.00869519 (rank : 12)	NC score	0.084537 (rank : 29)
Query Neighborhood Hits	37	Target Neighborhood Hits	471	Shared Neighborhood Hits	25
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

BIRC3_MOUSE
θ value	0.0148317 (rank : 13)	NC score	0.196642 (rank : 13)
Query Neighborhood Hits	37	Target Neighborhood Hits	113	Shared Neighborhood Hits	25
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

RNF34_HUMAN
θ value	0.0148317 (rank : 14)	NC score	0.222897 (rank : 8)
Query Neighborhood Hits	37	Target Neighborhood Hits	153	Shared Neighborhood Hits	25
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	0.0252991 (rank : 15)	NC score	0.223911 (rank : 7)
Query Neighborhood Hits	37	Target Neighborhood Hits	160	Shared Neighborhood Hits	25
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RFFL_HUMAN
θ value	0.0431538 (rank : 16)	NC score	0.207436 (rank : 10)
Query Neighborhood Hits	37	Target Neighborhood Hits	175	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	0.0431538 (rank : 17)	NC score	0.211286 (rank : 9)
Query Neighborhood Hits	37	Target Neighborhood Hits	145	Shared Neighborhood Hits	24
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

PEX12_HUMAN
θ value	0.0736092 (rank : 18)	NC score	0.124393 (rank : 20)
Query Neighborhood Hits	37	Target Neighborhood Hits	32	Shared Neighborhood Hits	6
SwissProt Accessions	O00623	Gene names	PEX12, PAF3
Domain Architecture
Description	Peroxisome assembly protein 12 (Peroxin-12) (Peroxisome assembly factor 3) (PAF-3).

RNF12_MOUSE
θ value	0.0736092 (rank : 19)	NC score	0.097586 (rank : 25)
Query Neighborhood Hits	37	Target Neighborhood Hits	159	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WTV7	Gene names	Rnf12, Rlim
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM).

BIRC4_MOUSE
θ value	0.0961366 (rank : 20)	NC score	0.179200 (rank : 15)
Query Neighborhood Hits	37	Target Neighborhood Hits	89	Shared Neighborhood Hits	26
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

MGRN1_HUMAN
θ value	0.0961366 (rank : 21)	NC score	0.173758 (rank : 17)
Query Neighborhood Hits	37	Target Neighborhood Hits	192	Shared Neighborhood Hits	25
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MGRN1_MOUSE
θ value	0.0961366 (rank : 22)	NC score	0.178076 (rank : 16)
Query Neighborhood Hits	37	Target Neighborhood Hits	149	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

PEX12_MOUSE
θ value	0.279714 (rank : 23)	NC score	0.116614 (rank : 22)
Query Neighborhood Hits	37	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VC48	Gene names	Pex12
Domain Architecture
Description	Peroxisome assembly protein 12 (Peroxin-12).

RNF6_HUMAN
θ value	0.279714 (rank : 24)	NC score	0.088681 (rank : 27)
Query Neighborhood Hits	37	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y252, Q9UF41	Gene names	RNF6
Domain Architecture
Description	RING finger protein 6 (RING-H2 protein).

BIRC4_HUMAN
θ value	0.365318 (rank : 25)	NC score	0.167279 (rank : 18)
Query Neighborhood Hits	37	Target Neighborhood Hits	89	Shared Neighborhood Hits	25
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

MYLIP_MOUSE
θ value	1.81305 (rank : 26)	NC score	0.072520 (rank : 33)
Query Neighborhood Hits	37	Target Neighborhood Hits	139	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_HUMAN
θ value	2.36792 (rank : 27)	NC score	0.080201 (rank : 32)
Query Neighborhood Hits	37	Target Neighborhood Hits	162	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

UBP32_HUMAN
θ value	2.36792 (rank : 28)	NC score	0.013620 (rank : 42)
Query Neighborhood Hits	37	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NFA0, Q9BX85, Q9Y591	Gene names	USP32, USP10
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.1.2.15) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) (Deubiquitinating enzyme 32) (NY-REN-60 antigen).

BIRC8_HUMAN
θ value	3.0926 (rank : 29)	NC score	0.139448 (rank : 19)
Query Neighborhood Hits	37	Target Neighborhood Hits	121	Shared Neighborhood Hits	22
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

CA156_MOUSE
θ value	3.0926 (rank : 30)	NC score	0.027718 (rank : 41)
Query Neighborhood Hits	37	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CZ09, Q810I8	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf156 homolog.

LRSM1_MOUSE
θ value	3.0926 (rank : 31)	NC score	0.063846 (rank : 34)
Query Neighborhood Hits	37	Target Neighborhood Hits	874	Shared Neighborhood Hits	25
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

NEIL3_MOUSE
θ value	4.03905 (rank : 32)	NC score	0.038966 (rank : 39)
Query Neighborhood Hits	37	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

LRSM1_HUMAN
θ value	5.27518 (rank : 33)	NC score	0.057480 (rank : 36)
Query Neighborhood Hits	37	Target Neighborhood Hits	1078	Shared Neighborhood Hits	25
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

NEIL3_HUMAN
θ value	6.88961 (rank : 34)	NC score	0.032783 (rank : 40)
Query Neighborhood Hits	37	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TAT5, Q2PPJ3, Q8NG51, Q9NV95	Gene names	NEIL3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

ACHA6_HUMAN
θ value	8.99809 (rank : 35)	NC score	0.006117 (rank : 44)
Query Neighborhood Hits	37	Target Neighborhood Hits	81	Shared Neighborhood Hits	4
SwissProt Accessions	Q15825	Gene names	CHRNA6
Domain Architecture
Description	Neuronal acetylcholine receptor protein subunit alpha-6 precursor.

GOGA4_HUMAN
θ value	8.99809 (rank : 36)	NC score	0.000269 (rank : 45)
Query Neighborhood Hits	37	Target Neighborhood Hits	2034	Shared Neighborhood Hits	5
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

POLK_MOUSE
θ value	8.99809 (rank : 37)	NC score	0.010831 (rank : 43)
Query Neighborhood Hits	37	Target Neighborhood Hits	66	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QUG2, Q7TPY7	Gene names	Polk, Dinb1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).

BIRC5_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.057583 (rank : 35)
Query Neighborhood Hits	37	Target Neighborhood Hits	20	Shared Neighborhood Hits	8
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

BIRC5_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.053506 (rank : 38)
Query Neighborhood Hits	37	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

BIRC7_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.123077 (rank : 21)
Query Neighborhood Hits	37	Target Neighborhood Hits	185	Shared Neighborhood Hits	23
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

CGRF1_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.086097 (rank : 28)
Query Neighborhood Hits	37	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

CGRF1_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.092538 (rank : 26)
Query Neighborhood Hits	37	Target Neighborhood Hits	47	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

RKHD1_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.084529 (rank : 30)
Query Neighborhood Hits	37	Target Neighborhood Hits	163	Shared Neighborhood Hits	21
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

RNF26_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.106865 (rank : 24)
Query Neighborhood Hits	37	Target Neighborhood Hits	95	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

TOPRS_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.054686 (rank : 37)
Query Neighborhood Hits	37	Target Neighborhood Hits	263	Shared Neighborhood Hits	16
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

Hits sorted by NC score

MDM4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	37	Target Neighborhood Hits	37	Shared Neighborhood Hits	37
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MDM4_MOUSE
NC score	0.986345 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	37	Target Neighborhood Hits	36	Shared Neighborhood Hits	24
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MDM2_HUMAN
NC score	0.877328 (rank : 3)	θ value	8.55514e-59 (rank : 3)
Query Neighborhood Hits	37	Target Neighborhood Hits	92	Shared Neighborhood Hits	25
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

MDM2_MOUSE
NC score	0.875077 (rank : 4)	θ value	3.36421e-55 (rank : 4)
Query Neighborhood Hits	37	Target Neighborhood Hits	77	Shared Neighborhood Hits	23
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

NEURL_MOUSE
NC score	0.266864 (rank : 5)	θ value	0.00175202 (rank : 6)
Query Neighborhood Hits	37	Target Neighborhood Hits	106	Shared Neighborhood Hits	27
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

NEUL1_HUMAN
NC score	0.261744 (rank : 6)	θ value	0.00228821 (rank : 7)
Query Neighborhood Hits	37	Target Neighborhood Hits	114	Shared Neighborhood Hits	27
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

RNF34_MOUSE
NC score	0.223911 (rank : 7)	θ value	0.0252991 (rank : 15)
Query Neighborhood Hits	37	Target Neighborhood Hits	160	Shared Neighborhood Hits	25
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RNF34_HUMAN
NC score	0.222897 (rank : 8)	θ value	0.0148317 (rank : 14)
Query Neighborhood Hits	37	Target Neighborhood Hits	153	Shared Neighborhood Hits	25
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RFFL_MOUSE
NC score	0.211286 (rank : 9)	θ value	0.0431538 (rank : 17)
Query Neighborhood Hits	37	Target Neighborhood Hits	145	Shared Neighborhood Hits	24
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RFFL_HUMAN
NC score	0.207436 (rank : 10)	θ value	0.0431538 (rank : 16)
Query Neighborhood Hits	37	Target Neighborhood Hits	175	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

BIRC2_MOUSE
NC score	0.201399 (rank : 11)	θ value	0.00175202 (rank : 5)
Query Neighborhood Hits	37	Target Neighborhood Hits	137	Shared Neighborhood Hits	25
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC3_HUMAN
NC score	0.199577 (rank : 12)	θ value	0.00869519 (rank : 10)
Query Neighborhood Hits	37	Target Neighborhood Hits	133	Shared Neighborhood Hits	25
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC3_MOUSE
NC score	0.196642 (rank : 13)	θ value	0.0148317 (rank : 13)
Query Neighborhood Hits	37	Target Neighborhood Hits	113	Shared Neighborhood Hits	25
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC2_HUMAN
NC score	0.182622 (rank : 14)	θ value	0.00869519 (rank : 9)
Query Neighborhood Hits	37	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC4_MOUSE
NC score	0.179200 (rank : 15)	θ value	0.0961366 (rank : 20)
Query Neighborhood Hits	37	Target Neighborhood Hits	89	Shared Neighborhood Hits	26
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

MGRN1_MOUSE
NC score	0.178076 (rank : 16)	θ value	0.0961366 (rank : 22)
Query Neighborhood Hits	37	Target Neighborhood Hits	149	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

MGRN1_HUMAN
NC score	0.173758 (rank : 17)	θ value	0.0961366 (rank : 21)
Query Neighborhood Hits	37	Target Neighborhood Hits	192	Shared Neighborhood Hits	25
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

BIRC4_HUMAN
NC score	0.167279 (rank : 18)	θ value	0.365318 (rank : 25)
Query Neighborhood Hits	37	Target Neighborhood Hits	89	Shared Neighborhood Hits	25
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC8_HUMAN
NC score	0.139448 (rank : 19)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	37	Target Neighborhood Hits	121	Shared Neighborhood Hits	22
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

PEX12_HUMAN
NC score	0.124393 (rank : 20)	θ value	0.0736092 (rank : 18)
Query Neighborhood Hits	37	Target Neighborhood Hits	32	Shared Neighborhood Hits	6
SwissProt Accessions	O00623	Gene names	PEX12, PAF3
Domain Architecture
Description	Peroxisome assembly protein 12 (Peroxin-12) (Peroxisome assembly factor 3) (PAF-3).

BIRC7_HUMAN
NC score	0.123077 (rank : 21)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	37	Target Neighborhood Hits	185	Shared Neighborhood Hits	23
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

PEX12_MOUSE
NC score	0.116614 (rank : 22)	θ value	0.279714 (rank : 23)
Query Neighborhood Hits	37	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VC48	Gene names	Pex12
Domain Architecture
Description	Peroxisome assembly protein 12 (Peroxin-12).

RNF12_HUMAN
NC score	0.114382 (rank : 23)	θ value	0.00665767 (rank : 8)
Query Neighborhood Hits	37	Target Neighborhood Hits	173	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NVW2, Q9Y598	Gene names	RNF12, RLIM
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (NY-REN-43 antigen).

RNF26_HUMAN
NC score	0.106865 (rank : 24)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	37	Target Neighborhood Hits	95	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

RNF12_MOUSE
NC score	0.097586 (rank : 25)	θ value	0.0736092 (rank : 19)
Query Neighborhood Hits	37	Target Neighborhood Hits	159	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WTV7	Gene names	Rnf12, Rlim
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM).

CGRF1_MOUSE
NC score	0.092538 (rank : 26)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	37	Target Neighborhood Hits	47	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

RNF6_HUMAN
NC score	0.088681 (rank : 27)	θ value	0.279714 (rank : 24)
Query Neighborhood Hits	37	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y252, Q9UF41	Gene names	RNF6
Domain Architecture
Description	RING finger protein 6 (RING-H2 protein).

CGRF1_HUMAN
NC score	0.086097 (rank : 28)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	37	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

MIB1_MOUSE
NC score	0.084537 (rank : 29)	θ value	0.00869519 (rank : 12)
Query Neighborhood Hits	37	Target Neighborhood Hits	471	Shared Neighborhood Hits	25
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

RKHD1_HUMAN
NC score	0.084529 (rank : 30)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	37	Target Neighborhood Hits	163	Shared Neighborhood Hits	21
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

MIB1_HUMAN
NC score	0.083649 (rank : 31)	θ value	0.00869519 (rank : 11)
Query Neighborhood Hits	37	Target Neighborhood Hits	470	Shared Neighborhood Hits	25
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MYLIP_HUMAN
NC score	0.080201 (rank : 32)	θ value	2.36792 (rank : 27)
Query Neighborhood Hits	37	Target Neighborhood Hits	162	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
NC score	0.072520 (rank : 33)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	37	Target Neighborhood Hits	139	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

LRSM1_MOUSE
NC score	0.063846 (rank : 34)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	37	Target Neighborhood Hits	874	Shared Neighborhood Hits	25
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

BIRC5_HUMAN
NC score	0.057583 (rank : 35)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	37	Target Neighborhood Hits	20	Shared Neighborhood Hits	8
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

LRSM1_HUMAN
NC score	0.057480 (rank : 36)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	37	Target Neighborhood Hits	1078	Shared Neighborhood Hits	25
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

TOPRS_MOUSE
NC score	0.054686 (rank : 37)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	37	Target Neighborhood Hits	263	Shared Neighborhood Hits	16
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

BIRC5_MOUSE
NC score	0.053506 (rank : 38)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	37	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

NEIL3_MOUSE
NC score	0.038966 (rank : 39)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	37	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

NEIL3_HUMAN
NC score	0.032783 (rank : 40)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	37	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TAT5, Q2PPJ3, Q8NG51, Q9NV95	Gene names	NEIL3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

CA156_MOUSE
NC score	0.027718 (rank : 41)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	37	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CZ09, Q810I8	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf156 homolog.

UBP32_HUMAN
NC score	0.013620 (rank : 42)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	37	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NFA0, Q9BX85, Q9Y591	Gene names	USP32, USP10
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.1.2.15) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) (Deubiquitinating enzyme 32) (NY-REN-60 antigen).

POLK_MOUSE
NC score	0.010831 (rank : 43)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	37	Target Neighborhood Hits	66	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QUG2, Q7TPY7	Gene names	Polk, Dinb1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).

ACHA6_HUMAN
NC score	0.006117 (rank : 44)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	37	Target Neighborhood Hits	81	Shared Neighborhood Hits	4
SwissProt Accessions	Q15825	Gene names	CHRNA6
Domain Architecture
Description	Neuronal acetylcholine receptor protein subunit alpha-6 precursor.

GOGA4_HUMAN
NC score	0.000269 (rank : 45)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	37	Target Neighborhood Hits	2034	Shared Neighborhood Hits	5
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).