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Network neighborhood for query Sequence : MDM4_MOUSE

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MDM4_MOUSE
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MDM4_HUMAN
θ value	0 (rank : 1)	NC score	0.986345 (rank : 2)
Query Neighborhood Hits	36	Target Neighborhood Hits	37	Shared Neighborhood Hits	24
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MDM4_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	36	Target Neighborhood Hits	36	Shared Neighborhood Hits	36
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MDM2_HUMAN
θ value	2.10721e-57 (rank : 3)	NC score	0.870463 (rank : 4)
Query Neighborhood Hits	36	Target Neighborhood Hits	92	Shared Neighborhood Hits	21
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

MDM2_MOUSE
θ value	4.39379e-55 (rank : 4)	NC score	0.870787 (rank : 3)
Query Neighborhood Hits	36	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

NEURL_MOUSE
θ value	0.0252991 (rank : 5)	NC score	0.207531 (rank : 5)
Query Neighborhood Hits	36	Target Neighborhood Hits	106	Shared Neighborhood Hits	21
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

NEUL1_HUMAN
θ value	0.0330416 (rank : 6)	NC score	0.202851 (rank : 6)
Query Neighborhood Hits	36	Target Neighborhood Hits	114	Shared Neighborhood Hits	21
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

MIB1_HUMAN
θ value	0.0431538 (rank : 7)	NC score	0.063357 (rank : 27)
Query Neighborhood Hits	36	Target Neighborhood Hits	470	Shared Neighborhood Hits	19
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
θ value	0.0431538 (rank : 8)	NC score	0.064116 (rank : 26)
Query Neighborhood Hits	36	Target Neighborhood Hits	471	Shared Neighborhood Hits	19
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

RNF12_HUMAN
θ value	0.0961366 (rank : 9)	NC score	0.098663 (rank : 18)
Query Neighborhood Hits	36	Target Neighborhood Hits	173	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NVW2, Q9Y598	Gene names	RNF12, RLIM
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (NY-REN-43 antigen).

BIRC4_MOUSE
θ value	0.21417 (rank : 10)	NC score	0.109154 (rank : 15)
Query Neighborhood Hits	36	Target Neighborhood Hits	89	Shared Neighborhood Hits	17
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

PEX12_HUMAN
θ value	0.365318 (rank : 11)	NC score	0.115981 (rank : 11)
Query Neighborhood Hits	36	Target Neighborhood Hits	32	Shared Neighborhood Hits	8
SwissProt Accessions	O00623	Gene names	PEX12, PAF3
Domain Architecture
Description	Peroxisome assembly protein 12 (Peroxin-12) (Peroxisome assembly factor 3) (PAF-3).

PEX12_MOUSE
θ value	0.365318 (rank : 12)	NC score	0.108569 (rank : 16)
Query Neighborhood Hits	36	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VC48	Gene names	Pex12
Domain Architecture
Description	Peroxisome assembly protein 12 (Peroxin-12).

BIRC2_MOUSE
θ value	0.47712 (rank : 13)	NC score	0.116843 (rank : 8)
Query Neighborhood Hits	36	Target Neighborhood Hits	137	Shared Neighborhood Hits	17
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

RNF12_MOUSE
θ value	0.62314 (rank : 14)	NC score	0.082778 (rank : 22)
Query Neighborhood Hits	36	Target Neighborhood Hits	159	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WTV7	Gene names	Rnf12, Rlim
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM).

BACH1_HUMAN
θ value	0.813845 (rank : 15)	NC score	0.021928 (rank : 35)
Query Neighborhood Hits	36	Target Neighborhood Hits	289	Shared Neighborhood Hits	3
SwissProt Accessions	O14867, O43285	Gene names	BACH1
Domain Architecture
Description	Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303).

BIRC3_HUMAN
θ value	0.813845 (rank : 16)	NC score	0.115739 (rank : 12)
Query Neighborhood Hits	36	Target Neighborhood Hits	133	Shared Neighborhood Hits	17
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC3_MOUSE
θ value	0.813845 (rank : 17)	NC score	0.112114 (rank : 14)
Query Neighborhood Hits	36	Target Neighborhood Hits	113	Shared Neighborhood Hits	17
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC4_HUMAN
θ value	0.813845 (rank : 18)	NC score	0.096682 (rank : 21)
Query Neighborhood Hits	36	Target Neighborhood Hits	89	Shared Neighborhood Hits	17
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

RNF6_HUMAN
θ value	0.813845 (rank : 19)	NC score	0.075809 (rank : 23)
Query Neighborhood Hits	36	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y252, Q9UF41	Gene names	RNF6
Domain Architecture
Description	RING finger protein 6 (RING-H2 protein).

C1QBP_MOUSE
θ value	1.06291 (rank : 20)	NC score	0.042665 (rank : 30)
Query Neighborhood Hits	36	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	O35658	Gene names	C1qbp, Gc1qbp
Domain Architecture
Description	Complement component 1 Q subcomponent-binding protein, mitochondrial precursor (Glycoprotein gC1qBP) (C1qBP) (GC1q-R protein).

TRI37_HUMAN
θ value	1.38821 (rank : 21)	NC score	0.041283 (rank : 32)
Query Neighborhood Hits	36	Target Neighborhood Hits	307	Shared Neighborhood Hits	11
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

TRI37_MOUSE
θ value	1.38821 (rank : 22)	NC score	0.040921 (rank : 33)
Query Neighborhood Hits	36	Target Neighborhood Hits	316	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

MEF2C_MOUSE
θ value	3.0926 (rank : 23)	NC score	0.015913 (rank : 38)
Query Neighborhood Hits	36	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CFN5, Q8R0H1, Q9D7L0, Q9QW20	Gene names	Mef2c
Domain Architecture	No domain graphic available
Description	Myocyte-specific enhancer factor 2C.

MGRN1_HUMAN
θ value	3.0926 (rank : 24)	NC score	0.113142 (rank : 13)
Query Neighborhood Hits	36	Target Neighborhood Hits	192	Shared Neighborhood Hits	21
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

NEIL3_MOUSE
θ value	3.0926 (rank : 25)	NC score	0.041656 (rank : 31)
Query Neighborhood Hits	36	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

TOPRS_MOUSE
θ value	3.0926 (rank : 26)	NC score	0.070772 (rank : 24)
Query Neighborhood Hits	36	Target Neighborhood Hits	263	Shared Neighborhood Hits	18
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

BACH1_MOUSE
θ value	4.03905 (rank : 27)	NC score	0.017900 (rank : 36)
Query Neighborhood Hits	36	Target Neighborhood Hits	289	Shared Neighborhood Hits	3
SwissProt Accessions	P97302	Gene names	Bach1
Domain Architecture
Description	Transcription regulator protein BACH1 (BTB and CNC homolog 1).

MGRN1_MOUSE
θ value	4.03905 (rank : 28)	NC score	0.116511 (rank : 10)
Query Neighborhood Hits	36	Target Neighborhood Hits	149	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

RNF34_MOUSE
θ value	4.03905 (rank : 29)	NC score	0.118102 (rank : 7)
Query Neighborhood Hits	36	Target Neighborhood Hits	160	Shared Neighborhood Hits	19
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

TOPRS_HUMAN
θ value	4.03905 (rank : 30)	NC score	0.057994 (rank : 29)
Query Neighborhood Hits	36	Target Neighborhood Hits	286	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

MYPC2_HUMAN
θ value	5.27518 (rank : 31)	NC score	0.009151 (rank : 40)
Query Neighborhood Hits	36	Target Neighborhood Hits	316	Shared Neighborhood Hits	3
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

TITIN_HUMAN
θ value	5.27518 (rank : 32)	NC score	0.001178 (rank : 41)
Query Neighborhood Hits	36	Target Neighborhood Hits	2923	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

NEIL3_HUMAN
θ value	6.88961 (rank : 33)	NC score	0.034807 (rank : 34)
Query Neighborhood Hits	36	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TAT5, Q2PPJ3, Q8NG51, Q9NV95	Gene names	NEIL3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

RNF34_HUMAN
θ value	6.88961 (rank : 34)	NC score	0.116569 (rank : 9)
Query Neighborhood Hits	36	Target Neighborhood Hits	153	Shared Neighborhood Hits	19
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RP9_MOUSE
θ value	8.99809 (rank : 35)	NC score	0.016371 (rank : 37)
Query Neighborhood Hits	36	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	P97762	Gene names	Rp9, Rp9h
Domain Architecture	No domain graphic available
Description	Retinitis pigmentosa 9 protein homolog (Pim-1-associated protein) (PAP-1).

TAB2_HUMAN
θ value	8.99809 (rank : 36)	NC score	0.010799 (rank : 39)
Query Neighborhood Hits	36	Target Neighborhood Hits	169	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYJ8, O94838, Q6I9W8, Q76N06, Q9UFP7	Gene names	MAP3K7IP2, KIAA0733, TAB2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2).

BIRC2_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.096904 (rank : 19)
Query Neighborhood Hits	36	Target Neighborhood Hits	142	Shared Neighborhood Hits	16
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC7_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.058489 (rank : 28)
Query Neighborhood Hits	36	Target Neighborhood Hits	185	Shared Neighborhood Hits	15
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

BIRC8_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.066626 (rank : 25)
Query Neighborhood Hits	36	Target Neighborhood Hits	121	Shared Neighborhood Hits	14
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

RFFL_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.096815 (rank : 20)
Query Neighborhood Hits	36	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.099079 (rank : 17)
Query Neighborhood Hits	36	Target Neighborhood Hits	145	Shared Neighborhood Hits	16
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

Hits sorted by NC score

MDM4_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	36	Target Neighborhood Hits	36	Shared Neighborhood Hits	36
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MDM4_HUMAN
NC score	0.986345 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	36	Target Neighborhood Hits	37	Shared Neighborhood Hits	24
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MDM2_MOUSE
NC score	0.870787 (rank : 3)	θ value	4.39379e-55 (rank : 4)
Query Neighborhood Hits	36	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

MDM2_HUMAN
NC score	0.870463 (rank : 4)	θ value	2.10721e-57 (rank : 3)
Query Neighborhood Hits	36	Target Neighborhood Hits	92	Shared Neighborhood Hits	21
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

NEURL_MOUSE
NC score	0.207531 (rank : 5)	θ value	0.0252991 (rank : 5)
Query Neighborhood Hits	36	Target Neighborhood Hits	106	Shared Neighborhood Hits	21
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

NEUL1_HUMAN
NC score	0.202851 (rank : 6)	θ value	0.0330416 (rank : 6)
Query Neighborhood Hits	36	Target Neighborhood Hits	114	Shared Neighborhood Hits	21
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

RNF34_MOUSE
NC score	0.118102 (rank : 7)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	36	Target Neighborhood Hits	160	Shared Neighborhood Hits	19
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

BIRC2_MOUSE
NC score	0.116843 (rank : 8)	θ value	0.47712 (rank : 13)
Query Neighborhood Hits	36	Target Neighborhood Hits	137	Shared Neighborhood Hits	17
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

RNF34_HUMAN
NC score	0.116569 (rank : 9)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	36	Target Neighborhood Hits	153	Shared Neighborhood Hits	19
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

MGRN1_MOUSE
NC score	0.116511 (rank : 10)	θ value	4.03905 (rank : 28)
Query Neighborhood Hits	36	Target Neighborhood Hits	149	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

PEX12_HUMAN
NC score	0.115981 (rank : 11)	θ value	0.365318 (rank : 11)
Query Neighborhood Hits	36	Target Neighborhood Hits	32	Shared Neighborhood Hits	8
SwissProt Accessions	O00623	Gene names	PEX12, PAF3
Domain Architecture
Description	Peroxisome assembly protein 12 (Peroxin-12) (Peroxisome assembly factor 3) (PAF-3).

BIRC3_HUMAN
NC score	0.115739 (rank : 12)	θ value	0.813845 (rank : 16)
Query Neighborhood Hits	36	Target Neighborhood Hits	133	Shared Neighborhood Hits	17
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

MGRN1_HUMAN
NC score	0.113142 (rank : 13)	θ value	3.0926 (rank : 24)
Query Neighborhood Hits	36	Target Neighborhood Hits	192	Shared Neighborhood Hits	21
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

BIRC3_MOUSE
NC score	0.112114 (rank : 14)	θ value	0.813845 (rank : 17)
Query Neighborhood Hits	36	Target Neighborhood Hits	113	Shared Neighborhood Hits	17
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC4_MOUSE
NC score	0.109154 (rank : 15)	θ value	0.21417 (rank : 10)
Query Neighborhood Hits	36	Target Neighborhood Hits	89	Shared Neighborhood Hits	17
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

PEX12_MOUSE
NC score	0.108569 (rank : 16)	θ value	0.365318 (rank : 12)
Query Neighborhood Hits	36	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VC48	Gene names	Pex12
Domain Architecture
Description	Peroxisome assembly protein 12 (Peroxin-12).

RFFL_MOUSE
NC score	0.099079 (rank : 17)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	36	Target Neighborhood Hits	145	Shared Neighborhood Hits	16
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RNF12_HUMAN
NC score	0.098663 (rank : 18)	θ value	0.0961366 (rank : 9)
Query Neighborhood Hits	36	Target Neighborhood Hits	173	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NVW2, Q9Y598	Gene names	RNF12, RLIM
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (NY-REN-43 antigen).

BIRC2_HUMAN
NC score	0.096904 (rank : 19)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	36	Target Neighborhood Hits	142	Shared Neighborhood Hits	16
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

RFFL_HUMAN
NC score	0.096815 (rank : 20)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	36	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

BIRC4_HUMAN
NC score	0.096682 (rank : 21)	θ value	0.813845 (rank : 18)
Query Neighborhood Hits	36	Target Neighborhood Hits	89	Shared Neighborhood Hits	17
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

RNF12_MOUSE
NC score	0.082778 (rank : 22)	θ value	0.62314 (rank : 14)
Query Neighborhood Hits	36	Target Neighborhood Hits	159	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WTV7	Gene names	Rnf12, Rlim
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM).

RNF6_HUMAN
NC score	0.075809 (rank : 23)	θ value	0.813845 (rank : 19)
Query Neighborhood Hits	36	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y252, Q9UF41	Gene names	RNF6
Domain Architecture
Description	RING finger protein 6 (RING-H2 protein).

TOPRS_MOUSE
NC score	0.070772 (rank : 24)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	36	Target Neighborhood Hits	263	Shared Neighborhood Hits	18
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

BIRC8_HUMAN
NC score	0.066626 (rank : 25)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	36	Target Neighborhood Hits	121	Shared Neighborhood Hits	14
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

MIB1_MOUSE
NC score	0.064116 (rank : 26)	θ value	0.0431538 (rank : 8)
Query Neighborhood Hits	36	Target Neighborhood Hits	471	Shared Neighborhood Hits	19
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

MIB1_HUMAN
NC score	0.063357 (rank : 27)	θ value	0.0431538 (rank : 7)
Query Neighborhood Hits	36	Target Neighborhood Hits	470	Shared Neighborhood Hits	19
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

BIRC7_HUMAN
NC score	0.058489 (rank : 28)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	36	Target Neighborhood Hits	185	Shared Neighborhood Hits	15
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

TOPRS_HUMAN
NC score	0.057994 (rank : 29)	θ value	4.03905 (rank : 30)
Query Neighborhood Hits	36	Target Neighborhood Hits	286	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

C1QBP_MOUSE
NC score	0.042665 (rank : 30)	θ value	1.06291 (rank : 20)
Query Neighborhood Hits	36	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	O35658	Gene names	C1qbp, Gc1qbp
Domain Architecture
Description	Complement component 1 Q subcomponent-binding protein, mitochondrial precursor (Glycoprotein gC1qBP) (C1qBP) (GC1q-R protein).

NEIL3_MOUSE
NC score	0.041656 (rank : 31)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	36	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

TRI37_HUMAN
NC score	0.041283 (rank : 32)	θ value	1.38821 (rank : 21)
Query Neighborhood Hits	36	Target Neighborhood Hits	307	Shared Neighborhood Hits	11
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

TRI37_MOUSE
NC score	0.040921 (rank : 33)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	36	Target Neighborhood Hits	316	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

NEIL3_HUMAN
NC score	0.034807 (rank : 34)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	36	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TAT5, Q2PPJ3, Q8NG51, Q9NV95	Gene names	NEIL3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

BACH1_HUMAN
NC score	0.021928 (rank : 35)	θ value	0.813845 (rank : 15)
Query Neighborhood Hits	36	Target Neighborhood Hits	289	Shared Neighborhood Hits	3
SwissProt Accessions	O14867, O43285	Gene names	BACH1
Domain Architecture
Description	Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303).

BACH1_MOUSE
NC score	0.017900 (rank : 36)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	36	Target Neighborhood Hits	289	Shared Neighborhood Hits	3
SwissProt Accessions	P97302	Gene names	Bach1
Domain Architecture
Description	Transcription regulator protein BACH1 (BTB and CNC homolog 1).

RP9_MOUSE
NC score	0.016371 (rank : 37)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	36	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	P97762	Gene names	Rp9, Rp9h
Domain Architecture	No domain graphic available
Description	Retinitis pigmentosa 9 protein homolog (Pim-1-associated protein) (PAP-1).

MEF2C_MOUSE
NC score	0.015913 (rank : 38)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	36	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CFN5, Q8R0H1, Q9D7L0, Q9QW20	Gene names	Mef2c
Domain Architecture	No domain graphic available
Description	Myocyte-specific enhancer factor 2C.

TAB2_HUMAN
NC score	0.010799 (rank : 39)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	36	Target Neighborhood Hits	169	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYJ8, O94838, Q6I9W8, Q76N06, Q9UFP7	Gene names	MAP3K7IP2, KIAA0733, TAB2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2).

MYPC2_HUMAN
NC score	0.009151 (rank : 40)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	36	Target Neighborhood Hits	316	Shared Neighborhood Hits	3
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

TITIN_HUMAN
NC score	0.001178 (rank : 41)	θ value	5.27518 (rank : 32)
Query Neighborhood Hits	36	Target Neighborhood Hits	2923	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).