Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : MDM2_HUMAN

For an explanation of this page, click here

MDM2_HUMAN
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MDM2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	92	Target Neighborhood Hits	92	Shared Neighborhood Hits	92
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

MDM2_MOUSE
θ value	0 (rank : 2)	NC score	0.975358 (rank : 2)
Query Neighborhood Hits	92	Target Neighborhood Hits	77	Shared Neighborhood Hits	32
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

MDM4_HUMAN
θ value	8.55514e-59 (rank : 3)	NC score	0.877328 (rank : 3)
Query Neighborhood Hits	92	Target Neighborhood Hits	37	Shared Neighborhood Hits	25
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MDM4_MOUSE
θ value	2.10721e-57 (rank : 4)	NC score	0.870463 (rank : 4)
Query Neighborhood Hits	92	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

NEURL_MOUSE
θ value	0.00134147 (rank : 5)	NC score	0.263297 (rank : 5)
Query Neighborhood Hits	92	Target Neighborhood Hits	106	Shared Neighborhood Hits	30
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

NEUL1_HUMAN
θ value	0.00175202 (rank : 6)	NC score	0.259012 (rank : 6)
Query Neighborhood Hits	92	Target Neighborhood Hits	114	Shared Neighborhood Hits	30
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

BIRC3_HUMAN
θ value	0.0148317 (rank : 7)	NC score	0.171199 (rank : 13)
Query Neighborhood Hits	92	Target Neighborhood Hits	133	Shared Neighborhood Hits	27
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

RNF34_MOUSE
θ value	0.0330416 (rank : 8)	NC score	0.208226 (rank : 7)
Query Neighborhood Hits	92	Target Neighborhood Hits	160	Shared Neighborhood Hits	30
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RNF34_HUMAN
θ value	0.0431538 (rank : 9)	NC score	0.206869 (rank : 8)
Query Neighborhood Hits	92	Target Neighborhood Hits	153	Shared Neighborhood Hits	29
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

TOPRS_MOUSE
θ value	0.0431538 (rank : 10)	NC score	0.106765 (rank : 21)
Query Neighborhood Hits	92	Target Neighborhood Hits	263	Shared Neighborhood Hits	22
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

BIRC2_MOUSE
θ value	0.0961366 (rank : 11)	NC score	0.168592 (rank : 14)
Query Neighborhood Hits	92	Target Neighborhood Hits	137	Shared Neighborhood Hits	27
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC3_MOUSE
θ value	0.0961366 (rank : 12)	NC score	0.167103 (rank : 15)
Query Neighborhood Hits	92	Target Neighborhood Hits	113	Shared Neighborhood Hits	27
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

MGRN1_MOUSE
θ value	0.125558 (rank : 13)	NC score	0.179191 (rank : 11)
Query Neighborhood Hits	92	Target Neighborhood Hits	149	Shared Neighborhood Hits	34
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

FANCM_HUMAN
θ value	0.163984 (rank : 14)	NC score	0.041645 (rank : 40)
Query Neighborhood Hits	92	Target Neighborhood Hits	210	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

LRSM1_HUMAN
θ value	0.21417 (rank : 15)	NC score	0.068589 (rank : 30)
Query Neighborhood Hits	92	Target Neighborhood Hits	1078	Shared Neighborhood Hits	40
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

MGRN1_HUMAN
θ value	0.21417 (rank : 16)	NC score	0.173300 (rank : 12)
Query Neighborhood Hits	92	Target Neighborhood Hits	192	Shared Neighborhood Hits	32
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

RFFL_MOUSE
θ value	0.21417 (rank : 17)	NC score	0.195692 (rank : 9)
Query Neighborhood Hits	92	Target Neighborhood Hits	145	Shared Neighborhood Hits	27
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

DSPP_HUMAN
θ value	0.279714 (rank : 18)	NC score	0.050954 (rank : 36)
Query Neighborhood Hits	92	Target Neighborhood Hits	645	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

RFFL_HUMAN
θ value	0.279714 (rank : 19)	NC score	0.191739 (rank : 10)
Query Neighborhood Hits	92	Target Neighborhood Hits	175	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

BIRC2_HUMAN
θ value	0.365318 (rank : 20)	NC score	0.152249 (rank : 16)
Query Neighborhood Hits	92	Target Neighborhood Hits	142	Shared Neighborhood Hits	26
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

MIB1_HUMAN
θ value	0.365318 (rank : 21)	NC score	0.068212 (rank : 31)
Query Neighborhood Hits	92	Target Neighborhood Hits	470	Shared Neighborhood Hits	30
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
θ value	0.365318 (rank : 22)	NC score	0.069480 (rank : 29)
Query Neighborhood Hits	92	Target Neighborhood Hits	471	Shared Neighborhood Hits	31
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

CHFR_MOUSE
θ value	0.47712 (rank : 23)	NC score	0.065611 (rank : 33)
Query Neighborhood Hits	92	Target Neighborhood Hits	264	Shared Neighborhood Hits	19
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

AN32A_HUMAN
θ value	0.62314 (rank : 24)	NC score	0.028943 (rank : 55)
Query Neighborhood Hits	92	Target Neighborhood Hits	234	Shared Neighborhood Hits	8
SwissProt Accessions	P39687	Gene names	ANP32A, C15orf1, LANP, MAPM, PHAP1
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member A (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Acidic nuclear phosphoprotein pp32) (Leucine-rich acidic nuclear protein) (Lanp) (Putative HLA-DR-associated protein I) (PHAPI) (Mapmodulin).

BIRC4_MOUSE
θ value	0.62314 (rank : 25)	NC score	0.149358 (rank : 17)
Query Neighborhood Hits	92	Target Neighborhood Hits	89	Shared Neighborhood Hits	27
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

LRSM1_MOUSE
θ value	0.62314 (rank : 26)	NC score	0.073522 (rank : 28)
Query Neighborhood Hits	92	Target Neighborhood Hits	874	Shared Neighborhood Hits	38
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

RBP2_MOUSE
θ value	0.62314 (rank : 27)	NC score	0.020241 (rank : 65)
Query Neighborhood Hits	92	Target Neighborhood Hits	232	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ERU9, Q61992, Q8C9K9	Gene names	Ranbp2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2 (RanBP2).

ZDH21_HUMAN
θ value	0.62314 (rank : 28)	NC score	0.036799 (rank : 46)
Query Neighborhood Hits	92	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IVQ6, Q5VWG1	Gene names	ZDHHC21
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC21 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 21) (DHHC-21).

ZDH21_MOUSE
θ value	0.62314 (rank : 29)	NC score	0.036860 (rank : 45)
Query Neighborhood Hits	92	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D270, Q6EMK1, Q80XQ3	Gene names	Zdhhc21, Gramp3
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC21 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 21) (DHHC-21) (GABA-A receptor-associated membrane protein 3).

BIRC4_HUMAN
θ value	0.813845 (rank : 30)	NC score	0.136958 (rank : 18)
Query Neighborhood Hits	92	Target Neighborhood Hits	89	Shared Neighborhood Hits	27
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

DSPP_MOUSE
θ value	0.813845 (rank : 31)	NC score	0.053137 (rank : 35)
Query Neighborhood Hits	92	Target Neighborhood Hits	491	Shared Neighborhood Hits	26
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

NALP5_MOUSE
θ value	0.813845 (rank : 32)	NC score	0.022903 (rank : 61)
Query Neighborhood Hits	92	Target Neighborhood Hits	560	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NPBL_MOUSE
θ value	0.813845 (rank : 33)	NC score	0.045149 (rank : 39)
Query Neighborhood Hits	92	Target Neighborhood Hits	1041	Shared Neighborhood Hits	29
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

ZRAB2_HUMAN
θ value	0.813845 (rank : 34)	NC score	0.061035 (rank : 34)
Query Neighborhood Hits	92	Target Neighborhood Hits	120	Shared Neighborhood Hits	7
SwissProt Accessions	O95218, Q9UP63	Gene names	ZRANB2, ZIS, ZNF265
Domain Architecture
Description	Zinc finger Ran-binding domain-containing protein 2 Zinc finger protein 265 (Zinc finger, splicing).

MYLIP_HUMAN
θ value	1.06291 (rank : 35)	NC score	0.075786 (rank : 27)
Query Neighborhood Hits	92	Target Neighborhood Hits	162	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

NIPBL_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.041007 (rank : 41)
Query Neighborhood Hits	92	Target Neighborhood Hits	1311	Shared Neighborhood Hits	35
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

RPGR_HUMAN
θ value	1.38821 (rank : 37)	NC score	0.029036 (rank : 54)
Query Neighborhood Hits	92	Target Neighborhood Hits	279	Shared Neighborhood Hits	12
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

TOPRS_HUMAN
θ value	1.38821 (rank : 38)	NC score	0.088152 (rank : 24)
Query Neighborhood Hits	92	Target Neighborhood Hits	286	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

CR034_MOUSE
θ value	1.81305 (rank : 39)	NC score	0.013957 (rank : 78)
Query Neighborhood Hits	92	Target Neighborhood Hits	643	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

MYLIP_MOUSE
θ value	1.81305 (rank : 40)	NC score	0.067795 (rank : 32)
Query Neighborhood Hits	92	Target Neighborhood Hits	139	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

ABTAP_MOUSE
θ value	2.36792 (rank : 41)	NC score	0.032616 (rank : 49)
Query Neighborhood Hits	92	Target Neighborhood Hits	381	Shared Neighborhood Hits	15
SwissProt Accessions	Q3V1V3	Gene names	Abtap
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

FA13C_HUMAN
θ value	2.36792 (rank : 42)	NC score	0.024060 (rank : 60)
Query Neighborhood Hits	92	Target Neighborhood Hits	94	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NE31, Q99787	Gene names	FAM13C1
Domain Architecture	No domain graphic available
Description	Protein FAM13C1.

PHF14_HUMAN
θ value	2.36792 (rank : 43)	NC score	0.030254 (rank : 51)
Query Neighborhood Hits	92	Target Neighborhood Hits	447	Shared Neighborhood Hits	16
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

PHF14_MOUSE
θ value	2.36792 (rank : 44)	NC score	0.030025 (rank : 52)
Query Neighborhood Hits	92	Target Neighborhood Hits	342	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

BCL6_HUMAN
θ value	3.0926 (rank : 45)	NC score	0.001364 (rank : 97)
Query Neighborhood Hits	92	Target Neighborhood Hits	922	Shared Neighborhood Hits	3
SwissProt Accessions	P41182	Gene names	BCL6, BCL5, LAZ3, ZBTB27, ZNF51
Domain Architecture
Description	B-cell lymphoma 6 protein (BCL-6) (Zinc finger protein 51) (LAZ-3 protein) (BCL-5) (Zinc finger and BTB domain-containing protein 27).

BCL6_MOUSE
θ value	3.0926 (rank : 46)	NC score	0.001461 (rank : 96)
Query Neighborhood Hits	92	Target Neighborhood Hits	913	Shared Neighborhood Hits	4
SwissProt Accessions	P41183, Q61065	Gene names	Bcl6, Bcl-6
Domain Architecture
Description	B-cell lymphoma 6 protein homolog.

CHD9_MOUSE
θ value	3.0926 (rank : 47)	NC score	0.015882 (rank : 74)
Query Neighborhood Hits	92	Target Neighborhood Hits	427	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

LEO1_MOUSE
θ value	3.0926 (rank : 48)	NC score	0.040884 (rank : 42)
Query Neighborhood Hits	92	Target Neighborhood Hits	946	Shared Neighborhood Hits	35
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

PRP4B_HUMAN
θ value	3.0926 (rank : 49)	NC score	0.008470 (rank : 86)
Query Neighborhood Hits	92	Target Neighborhood Hits	1030	Shared Neighborhood Hits	13
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	3.0926 (rank : 50)	NC score	0.008304 (rank : 88)
Query Neighborhood Hits	92	Target Neighborhood Hits	1040	Shared Neighborhood Hits	11
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

RPGR1_MOUSE
θ value	3.0926 (rank : 51)	NC score	0.024892 (rank : 58)
Query Neighborhood Hits	92	Target Neighborhood Hits	713	Shared Neighborhood Hits	18
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

BIRC7_HUMAN
θ value	4.03905 (rank : 52)	NC score	0.114865 (rank : 19)
Query Neighborhood Hits	92	Target Neighborhood Hits	185	Shared Neighborhood Hits	28
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

CM007_MOUSE
θ value	4.03905 (rank : 53)	NC score	0.034063 (rank : 48)
Query Neighborhood Hits	92	Target Neighborhood Hits	416	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K2Y0, Q9CYU1, Q9D1Y0	Gene names
Domain Architecture	No domain graphic available
Description	Protein C13orf7 homolog.

NP1L1_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.020358 (rank : 63)
Query Neighborhood Hits	92	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	P55209	Gene names	NAP1L1, NRP
Domain Architecture
Description	Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP).

NP1L1_MOUSE
θ value	4.03905 (rank : 55)	NC score	0.020338 (rank : 64)
Query Neighborhood Hits	92	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	P28656, Q3UL14	Gene names	Nap1l1, Nrp
Domain Architecture
Description	Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (Brain protein DN38).

SESN1_MOUSE
θ value	4.03905 (rank : 56)	NC score	0.014357 (rank : 76)
Query Neighborhood Hits	92	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P58006, Q7TNF3	Gene names	Sesn1, Pa26, Sest1
Domain Architecture	No domain graphic available
Description	Sestrin-1 (p53-regulated protein PA26).

TRI37_HUMAN
θ value	4.03905 (rank : 57)	NC score	0.037679 (rank : 44)
Query Neighborhood Hits	92	Target Neighborhood Hits	307	Shared Neighborhood Hits	16
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

TRI37_MOUSE
θ value	4.03905 (rank : 58)	NC score	0.037730 (rank : 43)
Query Neighborhood Hits	92	Target Neighborhood Hits	316	Shared Neighborhood Hits	16
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

TXND2_HUMAN
θ value	4.03905 (rank : 59)	NC score	0.018572 (rank : 67)
Query Neighborhood Hits	92	Target Neighborhood Hits	793	Shared Neighborhood Hits	18
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

CHD1_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.015783 (rank : 75)
Query Neighborhood Hits	92	Target Neighborhood Hits	337	Shared Neighborhood Hits	12
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

DDIT3_HUMAN
θ value	5.27518 (rank : 61)	NC score	0.022177 (rank : 62)
Query Neighborhood Hits	92	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	P35638	Gene names	DDIT3, CHOP, GADD153
Domain Architecture
Description	DNA damage-inducible transcript 3 (DDIT-3) (Growth arrest and DNA- damage-inducible protein GADD153) (C/EBP-homologous protein) (CHOP).

DPF3_MOUSE
θ value	5.27518 (rank : 62)	NC score	0.012106 (rank : 80)
Query Neighborhood Hits	92	Target Neighborhood Hits	327	Shared Neighborhood Hits	2
SwissProt Accessions	P58269	Gene names	Dpf3, Cerd4
Domain Architecture	No domain graphic available
Description	Zinc-finger protein Dpf3 (cer-d4).

FA44A_HUMAN
θ value	5.27518 (rank : 63)	NC score	0.024900 (rank : 57)
Query Neighborhood Hits	92	Target Neighborhood Hits	280	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NFC6, Q6P0M8	Gene names	FAM44A
Domain Architecture	No domain graphic available
Description	Protein FAM44A.

LEF1_MOUSE
θ value	5.27518 (rank : 64)	NC score	0.011583 (rank : 82)
Query Neighborhood Hits	92	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	P27782	Gene names	Lef1, Lef-1
Domain Architecture
Description	Lymphoid enhancer-binding factor 1 (LEF-1).

RBM16_HUMAN
θ value	5.27518 (rank : 65)	NC score	0.018984 (rank : 66)
Query Neighborhood Hits	92	Target Neighborhood Hits	300	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UPN6, Q5TBU6, Q9BQN8, Q9BX43	Gene names	RBM16, KIAA1116
Domain Architecture
Description	Putative RNA-binding protein 16 (RNA-binding motif protein 16).

RN103_HUMAN
θ value	5.27518 (rank : 66)	NC score	0.045771 (rank : 38)
Query Neighborhood Hits	92	Target Neighborhood Hits	153	Shared Neighborhood Hits	10
SwissProt Accessions	O00237, Q8IVB9	Gene names	RNF103
Domain Architecture	No domain graphic available
Description	RING finger protein 103 (Zinc finger protein 103 homolog) (Zfp-103) (KF-1) (hKF-1).

RN103_MOUSE
θ value	5.27518 (rank : 67)	NC score	0.035852 (rank : 47)
Query Neighborhood Hits	92	Target Neighborhood Hits	143	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R1W3, O08670, O08883	Gene names	Rnf103, Zfp103
Domain Architecture	No domain graphic available
Description	RING finger protein 103 (Zinc finger protein 103) (Zfp-103) (KF-1) (mKF-1).

RN123_MOUSE
θ value	5.27518 (rank : 68)	NC score	0.029894 (rank : 53)
Query Neighborhood Hits	92	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

SLK_HUMAN
θ value	5.27518 (rank : 69)	NC score	0.002669 (rank : 94)
Query Neighborhood Hits	92	Target Neighborhood Hits	1775	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

AATF_MOUSE
θ value	6.88961 (rank : 70)	NC score	0.018311 (rank : 68)
Query Neighborhood Hits	92	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JKX4, Q7TQN1, Q8C5Q2, Q99P89	Gene names	Aatf, Che1, Trb
Domain Architecture	No domain graphic available
Description	Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) (Traube protein).

CGRF1_MOUSE
θ value	6.88961 (rank : 71)	NC score	0.096033 (rank : 23)
Query Neighborhood Hits	92	Target Neighborhood Hits	47	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

GIDRP_MOUSE
θ value	6.88961 (rank : 72)	NC score	0.024226 (rank : 59)
Query Neighborhood Hits	92	Target Neighborhood Hits	96	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BJM3, Q3UGJ8, Q5U5U8	Gene names	Gidrp88, D19Ertd386e
Domain Architecture	No domain graphic available
Description	Growth inhibition and differentiation-related protein 88 homolog.

NOP56_HUMAN
θ value	6.88961 (rank : 73)	NC score	0.018075 (rank : 69)
Query Neighborhood Hits	92	Target Neighborhood Hits	95	Shared Neighborhood Hits	8
SwissProt Accessions	O00567, Q9NQ05	Gene names	NOL5A, NOP56
Domain Architecture
Description	Nucleolar protein Nop56 (Nucleolar protein 5A).

RBCC1_MOUSE
θ value	6.88961 (rank : 74)	NC score	0.008045 (rank : 89)
Query Neighborhood Hits	92	Target Neighborhood Hits	1048	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

RBMX2_HUMAN
θ value	6.88961 (rank : 75)	NC score	0.012056 (rank : 81)
Query Neighborhood Hits	92	Target Neighborhood Hits	351	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y388, Q5JY82, Q9Y3I8	Gene names	RBMX2
Domain Architecture
Description	RNA-binding motif protein, X-linked 2.

RIMB1_MOUSE
θ value	6.88961 (rank : 76)	NC score	0.005617 (rank : 92)
Query Neighborhood Hits	92	Target Neighborhood Hits	1376	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RPC5_MOUSE
θ value	6.88961 (rank : 77)	NC score	0.015998 (rank : 73)
Query Neighborhood Hits	92	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CZT4, Q8CI35, Q9DBD1	Gene names	Polr3e, Sin
Domain Architecture
Description	DNA-directed RNA polymerases III 80 kDa polypeptide (EC 2.7.7.6) (RNA polymerase III subunit 5) (RPC5) (Sex-lethal interactor homolog).

SLK_MOUSE
θ value	6.88961 (rank : 78)	NC score	0.002313 (rank : 95)
Query Neighborhood Hits	92	Target Neighborhood Hits	1798	Shared Neighborhood Hits	22
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

TXND2_MOUSE
θ value	6.88961 (rank : 79)	NC score	0.030276 (rank : 50)
Query Neighborhood Hits	92	Target Neighborhood Hits	828	Shared Neighborhood Hits	28
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

ACHA6_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.006844 (rank : 91)
Query Neighborhood Hits	92	Target Neighborhood Hits	81	Shared Neighborhood Hits	4
SwissProt Accessions	Q15825	Gene names	CHRNA6
Domain Architecture
Description	Neuronal acetylcholine receptor protein subunit alpha-6 precursor.

ASPX_MOUSE
θ value	8.99809 (rank : 81)	NC score	0.017110 (rank : 70)
Query Neighborhood Hits	92	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	P50289, Q9DAM6	Gene names	Acrv1
Domain Architecture
Description	Acrosomal protein SP-10 precursor (Acrosomal vesicle protein 1) (MSA- 63).

ATS18_MOUSE
θ value	8.99809 (rank : 82)	NC score	0.002675 (rank : 93)
Query Neighborhood Hits	92	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

CCAR1_MOUSE
θ value	8.99809 (rank : 83)	NC score	0.016677 (rank : 72)
Query Neighborhood Hits	92	Target Neighborhood Hits	414	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CH18, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5	Gene names	Ccar1, Carp1
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1).

CHD1_MOUSE
θ value	8.99809 (rank : 84)	NC score	0.014238 (rank : 77)
Query Neighborhood Hits	92	Target Neighborhood Hits	266	Shared Neighborhood Hits	12
SwissProt Accessions	P40201	Gene names	Chd1, Chd-1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

FXR2_MOUSE
θ value	8.99809 (rank : 85)	NC score	0.010697 (rank : 85)
Query Neighborhood Hits	92	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVR4, Q9WVR5	Gene names	Fxr2, Fxr2h
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

PKD2_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.007534 (rank : 90)
Query Neighborhood Hits	92	Target Neighborhood Hits	105	Shared Neighborhood Hits	2
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

RPGR_MOUSE
θ value	8.99809 (rank : 87)	NC score	0.025699 (rank : 56)
Query Neighborhood Hits	92	Target Neighborhood Hits	281	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

SFRS4_MOUSE
θ value	8.99809 (rank : 88)	NC score	0.016718 (rank : 71)
Query Neighborhood Hits	92	Target Neighborhood Hits	406	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VE97, Q9JJC3	Gene names	Sfrs4
Domain Architecture
Description	Splicing factor, arginine/serine-rich 4.

SOX6_HUMAN
θ value	8.99809 (rank : 89)	NC score	0.011376 (rank : 83)
Query Neighborhood Hits	92	Target Neighborhood Hits	332	Shared Neighborhood Hits	11
SwissProt Accessions	P35712, Q9BXQ3, Q9BXQ4, Q9BXQ5, Q9H0I8	Gene names	SOX6
Domain Architecture
Description	Transcription factor SOX-6.

SOX6_MOUSE
θ value	8.99809 (rank : 90)	NC score	0.011106 (rank : 84)
Query Neighborhood Hits	92	Target Neighborhood Hits	341	Shared Neighborhood Hits	10
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

WDHD1_HUMAN
θ value	8.99809 (rank : 91)	NC score	0.008415 (rank : 87)
Query Neighborhood Hits	92	Target Neighborhood Hits	342	Shared Neighborhood Hits	7
SwissProt Accessions	O75717	Gene names	WDHD1, AND1
Domain Architecture
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

ZN330_MOUSE
θ value	8.99809 (rank : 92)	NC score	0.013472 (rank : 79)
Query Neighborhood Hits	92	Target Neighborhood Hits	86	Shared Neighborhood Hits	2
SwissProt Accessions	Q922H9, Q8C389, Q8K2M4	Gene names	Znf330, Noa36, Zfp330
Domain Architecture	No domain graphic available
Description	Zinc finger protein 330 (Nucleolar cysteine-rich protein) (Nucleolar autoantigen 36).

BIRC5_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.050011 (rank : 37)
Query Neighborhood Hits	92	Target Neighborhood Hits	20	Shared Neighborhood Hits	8
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

BIRC8_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.109674 (rank : 20)
Query Neighborhood Hits	92	Target Neighborhood Hits	121	Shared Neighborhood Hits	24
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

CGRF1_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.082422 (rank : 25)
Query Neighborhood Hits	92	Target Neighborhood Hits	51	Shared Neighborhood Hits	22
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

RKHD1_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.081867 (rank : 26)
Query Neighborhood Hits	92	Target Neighborhood Hits	163	Shared Neighborhood Hits	29
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

RNF26_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.097626 (rank : 22)
Query Neighborhood Hits	92	Target Neighborhood Hits	95	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

Hits sorted by NC score

MDM2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	92	Target Neighborhood Hits	92	Shared Neighborhood Hits	92
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

MDM2_MOUSE
NC score	0.975358 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	92	Target Neighborhood Hits	77	Shared Neighborhood Hits	32
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

MDM4_HUMAN
NC score	0.877328 (rank : 3)	θ value	8.55514e-59 (rank : 3)
Query Neighborhood Hits	92	Target Neighborhood Hits	37	Shared Neighborhood Hits	25
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MDM4_MOUSE
NC score	0.870463 (rank : 4)	θ value	2.10721e-57 (rank : 4)
Query Neighborhood Hits	92	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

NEURL_MOUSE
NC score	0.263297 (rank : 5)	θ value	0.00134147 (rank : 5)
Query Neighborhood Hits	92	Target Neighborhood Hits	106	Shared Neighborhood Hits	30
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

NEUL1_HUMAN
NC score	0.259012 (rank : 6)	θ value	0.00175202 (rank : 6)
Query Neighborhood Hits	92	Target Neighborhood Hits	114	Shared Neighborhood Hits	30
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

RNF34_MOUSE
NC score	0.208226 (rank : 7)	θ value	0.0330416 (rank : 8)
Query Neighborhood Hits	92	Target Neighborhood Hits	160	Shared Neighborhood Hits	30
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RNF34_HUMAN
NC score	0.206869 (rank : 8)	θ value	0.0431538 (rank : 9)
Query Neighborhood Hits	92	Target Neighborhood Hits	153	Shared Neighborhood Hits	29
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RFFL_MOUSE
NC score	0.195692 (rank : 9)	θ value	0.21417 (rank : 17)
Query Neighborhood Hits	92	Target Neighborhood Hits	145	Shared Neighborhood Hits	27
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RFFL_HUMAN
NC score	0.191739 (rank : 10)	θ value	0.279714 (rank : 19)
Query Neighborhood Hits	92	Target Neighborhood Hits	175	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

MGRN1_MOUSE
NC score	0.179191 (rank : 11)	θ value	0.125558 (rank : 13)
Query Neighborhood Hits	92	Target Neighborhood Hits	149	Shared Neighborhood Hits	34
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

MGRN1_HUMAN
NC score	0.173300 (rank : 12)	θ value	0.21417 (rank : 16)
Query Neighborhood Hits	92	Target Neighborhood Hits	192	Shared Neighborhood Hits	32
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

BIRC3_HUMAN
NC score	0.171199 (rank : 13)	θ value	0.0148317 (rank : 7)
Query Neighborhood Hits	92	Target Neighborhood Hits	133	Shared Neighborhood Hits	27
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC2_MOUSE
NC score	0.168592 (rank : 14)	θ value	0.0961366 (rank : 11)
Query Neighborhood Hits	92	Target Neighborhood Hits	137	Shared Neighborhood Hits	27
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC3_MOUSE
NC score	0.167103 (rank : 15)	θ value	0.0961366 (rank : 12)
Query Neighborhood Hits	92	Target Neighborhood Hits	113	Shared Neighborhood Hits	27
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC2_HUMAN
NC score	0.152249 (rank : 16)	θ value	0.365318 (rank : 20)
Query Neighborhood Hits	92	Target Neighborhood Hits	142	Shared Neighborhood Hits	26
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC4_MOUSE
NC score	0.149358 (rank : 17)	θ value	0.62314 (rank : 25)
Query Neighborhood Hits	92	Target Neighborhood Hits	89	Shared Neighborhood Hits	27
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

BIRC4_HUMAN
NC score	0.136958 (rank : 18)	θ value	0.813845 (rank : 30)
Query Neighborhood Hits	92	Target Neighborhood Hits	89	Shared Neighborhood Hits	27
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC7_HUMAN
NC score	0.114865 (rank : 19)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	92	Target Neighborhood Hits	185	Shared Neighborhood Hits	28
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

BIRC8_HUMAN
NC score	0.109674 (rank : 20)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	92	Target Neighborhood Hits	121	Shared Neighborhood Hits	24
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

TOPRS_MOUSE
NC score	0.106765 (rank : 21)	θ value	0.0431538 (rank : 10)
Query Neighborhood Hits	92	Target Neighborhood Hits	263	Shared Neighborhood Hits	22
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

RNF26_HUMAN
NC score	0.097626 (rank : 22)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	92	Target Neighborhood Hits	95	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

CGRF1_MOUSE
NC score	0.096033 (rank : 23)	θ value	6.88961 (rank : 71)
Query Neighborhood Hits	92	Target Neighborhood Hits	47	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

TOPRS_HUMAN
NC score	0.088152 (rank : 24)	θ value	1.38821 (rank : 38)
Query Neighborhood Hits	92	Target Neighborhood Hits	286	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

CGRF1_HUMAN
NC score	0.082422 (rank : 25)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	92	Target Neighborhood Hits	51	Shared Neighborhood Hits	22
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

RKHD1_HUMAN
NC score	0.081867 (rank : 26)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	92	Target Neighborhood Hits	163	Shared Neighborhood Hits	29
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

MYLIP_HUMAN
NC score	0.075786 (rank : 27)	θ value	1.06291 (rank : 35)
Query Neighborhood Hits	92	Target Neighborhood Hits	162	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

LRSM1_MOUSE
NC score	0.073522 (rank : 28)	θ value	0.62314 (rank : 26)
Query Neighborhood Hits	92	Target Neighborhood Hits	874	Shared Neighborhood Hits	38
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

MIB1_MOUSE
NC score	0.069480 (rank : 29)	θ value	0.365318 (rank : 22)
Query Neighborhood Hits	92	Target Neighborhood Hits	471	Shared Neighborhood Hits	31
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

LRSM1_HUMAN
NC score	0.068589 (rank : 30)	θ value	0.21417 (rank : 15)
Query Neighborhood Hits	92	Target Neighborhood Hits	1078	Shared Neighborhood Hits	40
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

MIB1_HUMAN
NC score	0.068212 (rank : 31)	θ value	0.365318 (rank : 21)
Query Neighborhood Hits	92	Target Neighborhood Hits	470	Shared Neighborhood Hits	30
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MYLIP_MOUSE
NC score	0.067795 (rank : 32)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	92	Target Neighborhood Hits	139	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

CHFR_MOUSE
NC score	0.065611 (rank : 33)	θ value	0.47712 (rank : 23)
Query Neighborhood Hits	92	Target Neighborhood Hits	264	Shared Neighborhood Hits	19
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

ZRAB2_HUMAN
NC score	0.061035 (rank : 34)	θ value	0.813845 (rank : 34)
Query Neighborhood Hits	92	Target Neighborhood Hits	120	Shared Neighborhood Hits	7
SwissProt Accessions	O95218, Q9UP63	Gene names	ZRANB2, ZIS, ZNF265
Domain Architecture
Description	Zinc finger Ran-binding domain-containing protein 2 Zinc finger protein 265 (Zinc finger, splicing).

DSPP_MOUSE
NC score	0.053137 (rank : 35)	θ value	0.813845 (rank : 31)
Query Neighborhood Hits	92	Target Neighborhood Hits	491	Shared Neighborhood Hits	26
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

DSPP_HUMAN
NC score	0.050954 (rank : 36)	θ value	0.279714 (rank : 18)
Query Neighborhood Hits	92	Target Neighborhood Hits	645	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

BIRC5_HUMAN
NC score	0.050011 (rank : 37)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	92	Target Neighborhood Hits	20	Shared Neighborhood Hits	8
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

RN103_HUMAN
NC score	0.045771 (rank : 38)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	92	Target Neighborhood Hits	153	Shared Neighborhood Hits	10
SwissProt Accessions	O00237, Q8IVB9	Gene names	RNF103
Domain Architecture	No domain graphic available
Description	RING finger protein 103 (Zinc finger protein 103 homolog) (Zfp-103) (KF-1) (hKF-1).

NPBL_MOUSE
NC score	0.045149 (rank : 39)	θ value	0.813845 (rank : 33)
Query Neighborhood Hits	92	Target Neighborhood Hits	1041	Shared Neighborhood Hits	29
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

FANCM_HUMAN
NC score	0.041645 (rank : 40)	θ value	0.163984 (rank : 14)
Query Neighborhood Hits	92	Target Neighborhood Hits	210	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

NIPBL_HUMAN
NC score	0.041007 (rank : 41)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	92	Target Neighborhood Hits	1311	Shared Neighborhood Hits	35
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

LEO1_MOUSE
NC score	0.040884 (rank : 42)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	92	Target Neighborhood Hits	946	Shared Neighborhood Hits	35
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

TRI37_MOUSE
NC score	0.037730 (rank : 43)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	92	Target Neighborhood Hits	316	Shared Neighborhood Hits	16
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

TRI37_HUMAN
NC score	0.037679 (rank : 44)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	92	Target Neighborhood Hits	307	Shared Neighborhood Hits	16
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

ZDH21_MOUSE
NC score	0.036860 (rank : 45)	θ value	0.62314 (rank : 29)
Query Neighborhood Hits	92	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D270, Q6EMK1, Q80XQ3	Gene names	Zdhhc21, Gramp3
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC21 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 21) (DHHC-21) (GABA-A receptor-associated membrane protein 3).

ZDH21_HUMAN
NC score	0.036799 (rank : 46)	θ value	0.62314 (rank : 28)
Query Neighborhood Hits	92	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IVQ6, Q5VWG1	Gene names	ZDHHC21
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC21 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 21) (DHHC-21).

RN103_MOUSE
NC score	0.035852 (rank : 47)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	92	Target Neighborhood Hits	143	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R1W3, O08670, O08883	Gene names	Rnf103, Zfp103
Domain Architecture	No domain graphic available
Description	RING finger protein 103 (Zinc finger protein 103) (Zfp-103) (KF-1) (mKF-1).

CM007_MOUSE
NC score	0.034063 (rank : 48)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	92	Target Neighborhood Hits	416	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K2Y0, Q9CYU1, Q9D1Y0	Gene names
Domain Architecture	No domain graphic available
Description	Protein C13orf7 homolog.

ABTAP_MOUSE
NC score	0.032616 (rank : 49)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	92	Target Neighborhood Hits	381	Shared Neighborhood Hits	15
SwissProt Accessions	Q3V1V3	Gene names	Abtap
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

TXND2_MOUSE
NC score	0.030276 (rank : 50)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	92	Target Neighborhood Hits	828	Shared Neighborhood Hits	28
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

PHF14_HUMAN
NC score	0.030254 (rank : 51)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	92	Target Neighborhood Hits	447	Shared Neighborhood Hits	16
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

PHF14_MOUSE
NC score	0.030025 (rank : 52)	θ value	2.36792 (rank : 44)
Query Neighborhood Hits	92	Target Neighborhood Hits	342	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

RN123_MOUSE
NC score	0.029894 (rank : 53)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	92	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

RPGR_HUMAN
NC score	0.029036 (rank : 54)	θ value	1.38821 (rank : 37)
Query Neighborhood Hits	92	Target Neighborhood Hits	279	Shared Neighborhood Hits	12
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

AN32A_HUMAN
NC score	0.028943 (rank : 55)	θ value	0.62314 (rank : 24)
Query Neighborhood Hits	92	Target Neighborhood Hits	234	Shared Neighborhood Hits	8
SwissProt Accessions	P39687	Gene names	ANP32A, C15orf1, LANP, MAPM, PHAP1
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member A (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Acidic nuclear phosphoprotein pp32) (Leucine-rich acidic nuclear protein) (Lanp) (Putative HLA-DR-associated protein I) (PHAPI) (Mapmodulin).

RPGR_MOUSE
NC score	0.025699 (rank : 56)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	92	Target Neighborhood Hits	281	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

FA44A_HUMAN
NC score	0.024900 (rank : 57)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	92	Target Neighborhood Hits	280	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NFC6, Q6P0M8	Gene names	FAM44A
Domain Architecture	No domain graphic available
Description	Protein FAM44A.

RPGR1_MOUSE
NC score	0.024892 (rank : 58)	θ value	3.0926 (rank : 51)
Query Neighborhood Hits	92	Target Neighborhood Hits	713	Shared Neighborhood Hits	18
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

GIDRP_MOUSE
NC score	0.024226 (rank : 59)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	92	Target Neighborhood Hits	96	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BJM3, Q3UGJ8, Q5U5U8	Gene names	Gidrp88, D19Ertd386e
Domain Architecture	No domain graphic available
Description	Growth inhibition and differentiation-related protein 88 homolog.

FA13C_HUMAN
NC score	0.024060 (rank : 60)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	92	Target Neighborhood Hits	94	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NE31, Q99787	Gene names	FAM13C1
Domain Architecture	No domain graphic available
Description	Protein FAM13C1.

NALP5_MOUSE
NC score	0.022903 (rank : 61)	θ value	0.813845 (rank : 32)
Query Neighborhood Hits	92	Target Neighborhood Hits	560	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

DDIT3_HUMAN
NC score	0.022177 (rank : 62)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	92	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	P35638	Gene names	DDIT3, CHOP, GADD153
Domain Architecture
Description	DNA damage-inducible transcript 3 (DDIT-3) (Growth arrest and DNA- damage-inducible protein GADD153) (C/EBP-homologous protein) (CHOP).

NP1L1_HUMAN
NC score	0.020358 (rank : 63)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	92	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	P55209	Gene names	NAP1L1, NRP
Domain Architecture
Description	Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP).

NP1L1_MOUSE
NC score	0.020338 (rank : 64)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	92	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	P28656, Q3UL14	Gene names	Nap1l1, Nrp
Domain Architecture
Description	Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (Brain protein DN38).

RBP2_MOUSE
NC score	0.020241 (rank : 65)	θ value	0.62314 (rank : 27)
Query Neighborhood Hits	92	Target Neighborhood Hits	232	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ERU9, Q61992, Q8C9K9	Gene names	Ranbp2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2 (RanBP2).

RBM16_HUMAN
NC score	0.018984 (rank : 66)	θ value	5.27518 (rank : 65)
Query Neighborhood Hits	92	Target Neighborhood Hits	300	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UPN6, Q5TBU6, Q9BQN8, Q9BX43	Gene names	RBM16, KIAA1116
Domain Architecture
Description	Putative RNA-binding protein 16 (RNA-binding motif protein 16).

TXND2_HUMAN
NC score	0.018572 (rank : 67)	θ value	4.03905 (rank : 59)
Query Neighborhood Hits	92	Target Neighborhood Hits	793	Shared Neighborhood Hits	18
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

AATF_MOUSE
NC score	0.018311 (rank : 68)	θ value	6.88961 (rank : 70)
Query Neighborhood Hits	92	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JKX4, Q7TQN1, Q8C5Q2, Q99P89	Gene names	Aatf, Che1, Trb
Domain Architecture	No domain graphic available
Description	Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) (Traube protein).

NOP56_HUMAN
NC score	0.018075 (rank : 69)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	92	Target Neighborhood Hits	95	Shared Neighborhood Hits	8
SwissProt Accessions	O00567, Q9NQ05	Gene names	NOL5A, NOP56
Domain Architecture
Description	Nucleolar protein Nop56 (Nucleolar protein 5A).

ASPX_MOUSE
NC score	0.017110 (rank : 70)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	92	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	P50289, Q9DAM6	Gene names	Acrv1
Domain Architecture
Description	Acrosomal protein SP-10 precursor (Acrosomal vesicle protein 1) (MSA- 63).

SFRS4_MOUSE
NC score	0.016718 (rank : 71)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	92	Target Neighborhood Hits	406	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VE97, Q9JJC3	Gene names	Sfrs4
Domain Architecture
Description	Splicing factor, arginine/serine-rich 4.

CCAR1_MOUSE
NC score	0.016677 (rank : 72)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	92	Target Neighborhood Hits	414	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CH18, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5	Gene names	Ccar1, Carp1
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1).

RPC5_MOUSE
NC score	0.015998 (rank : 73)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	92	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CZT4, Q8CI35, Q9DBD1	Gene names	Polr3e, Sin
Domain Architecture
Description	DNA-directed RNA polymerases III 80 kDa polypeptide (EC 2.7.7.6) (RNA polymerase III subunit 5) (RPC5) (Sex-lethal interactor homolog).

CHD9_MOUSE
NC score	0.015882 (rank : 74)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	92	Target Neighborhood Hits	427	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

CHD1_HUMAN
NC score	0.015783 (rank : 75)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	92	Target Neighborhood Hits	337	Shared Neighborhood Hits	12
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

SESN1_MOUSE
NC score	0.014357 (rank : 76)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	92	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P58006, Q7TNF3	Gene names	Sesn1, Pa26, Sest1
Domain Architecture	No domain graphic available
Description	Sestrin-1 (p53-regulated protein PA26).

CHD1_MOUSE
NC score	0.014238 (rank : 77)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	92	Target Neighborhood Hits	266	Shared Neighborhood Hits	12
SwissProt Accessions	P40201	Gene names	Chd1, Chd-1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

CR034_MOUSE
NC score	0.013957 (rank : 78)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	92	Target Neighborhood Hits	643	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

ZN330_MOUSE
NC score	0.013472 (rank : 79)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	92	Target Neighborhood Hits	86	Shared Neighborhood Hits	2
SwissProt Accessions	Q922H9, Q8C389, Q8K2M4	Gene names	Znf330, Noa36, Zfp330
Domain Architecture	No domain graphic available
Description	Zinc finger protein 330 (Nucleolar cysteine-rich protein) (Nucleolar autoantigen 36).

DPF3_MOUSE
NC score	0.012106 (rank : 80)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	92	Target Neighborhood Hits	327	Shared Neighborhood Hits	2
SwissProt Accessions	P58269	Gene names	Dpf3, Cerd4
Domain Architecture	No domain graphic available
Description	Zinc-finger protein Dpf3 (cer-d4).

RBMX2_HUMAN
NC score	0.012056 (rank : 81)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	92	Target Neighborhood Hits	351	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y388, Q5JY82, Q9Y3I8	Gene names	RBMX2
Domain Architecture
Description	RNA-binding motif protein, X-linked 2.

LEF1_MOUSE
NC score	0.011583 (rank : 82)	θ value	5.27518 (rank : 64)
Query Neighborhood Hits	92	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	P27782	Gene names	Lef1, Lef-1
Domain Architecture
Description	Lymphoid enhancer-binding factor 1 (LEF-1).

SOX6_HUMAN
NC score	0.011376 (rank : 83)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	92	Target Neighborhood Hits	332	Shared Neighborhood Hits	11
SwissProt Accessions	P35712, Q9BXQ3, Q9BXQ4, Q9BXQ5, Q9H0I8	Gene names	SOX6
Domain Architecture
Description	Transcription factor SOX-6.

SOX6_MOUSE
NC score	0.011106 (rank : 84)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	92	Target Neighborhood Hits	341	Shared Neighborhood Hits	10
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

FXR2_MOUSE
NC score	0.010697 (rank : 85)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	92	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVR4, Q9WVR5	Gene names	Fxr2, Fxr2h
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

PRP4B_HUMAN
NC score	0.008470 (rank : 86)	θ value	3.0926 (rank : 49)
Query Neighborhood Hits	92	Target Neighborhood Hits	1030	Shared Neighborhood Hits	13
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

WDHD1_HUMAN
NC score	0.008415 (rank : 87)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	92	Target Neighborhood Hits	342	Shared Neighborhood Hits	7
SwissProt Accessions	O75717	Gene names	WDHD1, AND1
Domain Architecture
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

PRP4B_MOUSE
NC score	0.008304 (rank : 88)	θ value	3.0926 (rank : 50)
Query Neighborhood Hits	92	Target Neighborhood Hits	1040	Shared Neighborhood Hits	11
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

RBCC1_MOUSE
NC score	0.008045 (rank : 89)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	92	Target Neighborhood Hits	1048	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

PKD2_HUMAN
NC score	0.007534 (rank : 90)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	92	Target Neighborhood Hits	105	Shared Neighborhood Hits	2
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

ACHA6_HUMAN
NC score	0.006844 (rank : 91)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	92	Target Neighborhood Hits	81	Shared Neighborhood Hits	4
SwissProt Accessions	Q15825	Gene names	CHRNA6
Domain Architecture
Description	Neuronal acetylcholine receptor protein subunit alpha-6 precursor.

RIMB1_MOUSE
NC score	0.005617 (rank : 92)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	92	Target Neighborhood Hits	1376	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ATS18_MOUSE
NC score	0.002675 (rank : 93)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	92	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

SLK_HUMAN
NC score	0.002669 (rank : 94)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	92	Target Neighborhood Hits	1775	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
NC score	0.002313 (rank : 95)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	92	Target Neighborhood Hits	1798	Shared Neighborhood Hits	22
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

BCL6_MOUSE
NC score	0.001461 (rank : 96)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	92	Target Neighborhood Hits	913	Shared Neighborhood Hits	4
SwissProt Accessions	P41183, Q61065	Gene names	Bcl6, Bcl-6
Domain Architecture
Description	B-cell lymphoma 6 protein homolog.

BCL6_HUMAN
NC score	0.001364 (rank : 97)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	92	Target Neighborhood Hits	922	Shared Neighborhood Hits	3
SwissProt Accessions	P41182	Gene names	BCL6, BCL5, LAZ3, ZBTB27, ZNF51
Domain Architecture
Description	B-cell lymphoma 6 protein (BCL-6) (Zinc finger protein 51) (LAZ-3 protein) (BCL-5) (Zinc finger and BTB domain-containing protein 27).