Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : ATS18_MOUSE

For an explanation of this page, click here

ATS18_MOUSE
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ATS16_HUMAN
θ value	0 (rank : 1)	NC score	0.993077 (rank : 4)
Query Neighborhood Hits	163	Target Neighborhood Hits	208	Shared Neighborhood Hits	138
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS16_MOUSE
θ value	0 (rank : 2)	NC score	0.993195 (rank : 3)
Query Neighborhood Hits	163	Target Neighborhood Hits	179	Shared Neighborhood Hits	136
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS18_HUMAN
θ value	0 (rank : 3)	NC score	0.997996 (rank : 2)
Query Neighborhood Hits	163	Target Neighborhood Hits	169	Shared Neighborhood Hits	143
SwissProt Accessions	Q8TE60, Q6P4R5, Q6ZWJ9	Gene names	ADAMTS18, ADAMTS21
Domain Architecture
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS18_MOUSE
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	163	Target Neighborhood Hits	163	Shared Neighborhood Hits	163
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS12_HUMAN
θ value	3.82926e-184 (rank : 5)	NC score	0.978484 (rank : 6)
Query Neighborhood Hits	163	Target Neighborhood Hits	251	Shared Neighborhood Hits	137
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS12_MOUSE
θ value	5.00115e-184 (rank : 6)	NC score	0.980296 (rank : 5)
Query Neighborhood Hits	163	Target Neighborhood Hits	220	Shared Neighborhood Hits	137
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS9_HUMAN
θ value	4.6918e-174 (rank : 7)	NC score	0.974180 (rank : 11)
Query Neighborhood Hits	163	Target Neighborhood Hits	219	Shared Neighborhood Hits	138
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

ATS20_MOUSE
θ value	5.19945e-165 (rank : 8)	NC score	0.973291 (rank : 12)
Query Neighborhood Hits	163	Target Neighborhood Hits	225	Shared Neighborhood Hits	134
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS6_HUMAN
θ value	7.76955e-161 (rank : 9)	NC score	0.976697 (rank : 8)
Query Neighborhood Hits	163	Target Neighborhood Hits	141	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UKP5	Gene names	ADAMTS6
Domain Architecture
Description	ADAMTS-6 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 6) (ADAM-TS 6) (ADAM-TS6).

ATS20_HUMAN
θ value	6.80647e-157 (rank : 10)	NC score	0.971178 (rank : 15)
Query Neighborhood Hits	163	Target Neighborhood Hits	192	Shared Neighborhood Hits	131
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS17_HUMAN
θ value	9.19922e-154 (rank : 11)	NC score	0.977065 (rank : 7)
Query Neighborhood Hits	163	Target Neighborhood Hits	194	Shared Neighborhood Hits	135
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

ATS19_HUMAN
θ value	2.76981e-150 (rank : 12)	NC score	0.969993 (rank : 18)
Query Neighborhood Hits	163	Target Neighborhood Hits	203	Shared Neighborhood Hits	130
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS7_HUMAN
θ value	1.05253e-149 (rank : 13)	NC score	0.975831 (rank : 9)
Query Neighborhood Hits	163	Target Neighborhood Hits	169	Shared Neighborhood Hits	128
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

ATS3_HUMAN
θ value	7.54289e-148 (rank : 14)	NC score	0.974250 (rank : 10)
Query Neighborhood Hits	163	Target Neighborhood Hits	179	Shared Neighborhood Hits	133
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

ATS19_MOUSE
θ value	5.9766e-145 (rank : 15)	NC score	0.970780 (rank : 16)
Query Neighborhood Hits	163	Target Neighborhood Hits	188	Shared Neighborhood Hits	131
SwissProt Accessions	P59509	Gene names	Adamts19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS2_HUMAN
θ value	2.12569e-142 (rank : 16)	NC score	0.972317 (rank : 13)
Query Neighborhood Hits	163	Target Neighborhood Hits	179	Shared Neighborhood Hits	127
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS2_MOUSE
θ value	9.87422e-140 (rank : 17)	NC score	0.971354 (rank : 14)
Query Neighborhood Hits	163	Target Neighborhood Hits	179	Shared Neighborhood Hits	126
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS1_MOUSE
θ value	4.74654e-134 (rank : 18)	NC score	0.969556 (rank : 19)
Query Neighborhood Hits	163	Target Neighborhood Hits	158	Shared Neighborhood Hits	131
SwissProt Accessions	P97857, O54768	Gene names	Adamts1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1).

ATS14_HUMAN
θ value	5.80223e-132 (rank : 19)	NC score	0.963741 (rank : 22)
Query Neighborhood Hits	163	Target Neighborhood Hits	382	Shared Neighborhood Hits	130
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

ATS15_HUMAN
θ value	4.5974e-129 (rank : 20)	NC score	0.970455 (rank : 17)
Query Neighborhood Hits	163	Target Neighborhood Hits	151	Shared Neighborhood Hits	133
SwissProt Accessions	Q8TE58	Gene names	ADAMTS15
Domain Architecture
Description	ADAMTS-15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 15) (ADAM-TS 15) (ADAM-TS15).

ATS1_HUMAN
θ value	2.28167e-128 (rank : 21)	NC score	0.968643 (rank : 20)
Query Neighborhood Hits	163	Target Neighborhood Hits	159	Shared Neighborhood Hits	130
SwissProt Accessions	Q9UHI8, Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80	Gene names	ADAMTS1, KIAA1346, METH1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1) (METH-1).

ATS8_HUMAN
θ value	4.93473e-115 (rank : 22)	NC score	0.963972 (rank : 21)
Query Neighborhood Hits	163	Target Neighborhood Hits	145	Shared Neighborhood Hits	122
SwissProt Accessions	Q9UP79, Q9NZS0	Gene names	ADAMTS8, METH2
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) (METH- 8).

ATS8_MOUSE
θ value	2.80211e-110 (rank : 23)	NC score	0.957609 (rank : 25)
Query Neighborhood Hits	163	Target Neighborhood Hits	139	Shared Neighborhood Hits	116
SwissProt Accessions	P57110	Gene names	Adamts8
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2).

ATS13_MOUSE
θ value	4.77967e-110 (rank : 24)	NC score	0.943413 (rank : 29)
Query Neighborhood Hits	163	Target Neighborhood Hits	227	Shared Neighborhood Hits	124
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS13_HUMAN
θ value	1.39067e-109 (rank : 25)	NC score	0.944064 (rank : 28)
Query Neighborhood Hits	163	Target Neighborhood Hits	238	Shared Neighborhood Hits	119
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS5_MOUSE
θ value	1.59114e-105 (rank : 26)	NC score	0.962495 (rank : 23)
Query Neighborhood Hits	163	Target Neighborhood Hits	147	Shared Neighborhood Hits	121
SwissProt Accessions	Q9R001	Gene names	Adamts5
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (Implantin).

ATS5_HUMAN
θ value	2.54029e-103 (rank : 27)	NC score	0.959184 (rank : 24)
Query Neighborhood Hits	163	Target Neighborhood Hits	141	Shared Neighborhood Hits	119
SwissProt Accessions	Q9UNA0, Q9UKP2	Gene names	ADAMTS5, ADAMTS11, ADMP2
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).

ATS4_MOUSE
θ value	8.17181e-102 (rank : 28)	NC score	0.951555 (rank : 26)
Query Neighborhood Hits	163	Target Neighborhood Hits	145	Shared Neighborhood Hits	117
SwissProt Accessions	Q8BNJ2, Q8K384	Gene names	Adamts4
Domain Architecture	No domain graphic available
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1).

ATS4_HUMAN
θ value	2.90646e-99 (rank : 29)	NC score	0.950418 (rank : 27)
Query Neighborhood Hits	163	Target Neighborhood Hits	138	Shared Neighborhood Hits	113
SwissProt Accessions	O75173, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83	Gene names	ADAMTS4, KIAA0688
Domain Architecture
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1) (ADMP-1).

ATL3_HUMAN
θ value	2.23575e-83 (rank : 30)	NC score	0.769611 (rank : 35)
Query Neighborhood Hits	163	Target Neighborhood Hits	414	Shared Neighborhood Hits	96
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

ATL1_HUMAN
θ value	4.23606e-66 (rank : 31)	NC score	0.905940 (rank : 31)
Query Neighborhood Hits	163	Target Neighborhood Hits	93	Shared Neighborhood Hits	85
SwissProt Accessions	Q8N6G6, Q5T708, Q96RW4, Q9BXY3	Gene names	ADAMTSL1, ADAMTSR1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (ADAMTSL-1) (Punctin-1).

ATL1_MOUSE
θ value	9.48078e-50 (rank : 32)	NC score	0.896490 (rank : 32)
Query Neighborhood Hits	163	Target Neighborhood Hits	80	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BLI0	Gene names	Adamtsl1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (Punctin-1).

ATL2_MOUSE
θ value	1.36902e-48 (rank : 33)	NC score	0.875146 (rank : 33)
Query Neighborhood Hits	163	Target Neighborhood Hits	137	Shared Neighborhood Hits	88
SwissProt Accessions	Q7TSK7, Q3U0C8	Gene names	Adamtsl2, Kiaa0605, Tcp1
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2) (TSP1-repeats-containing protein 1) (TCP-1).

ATL5_HUMAN
θ value	1.36902e-48 (rank : 34)	NC score	0.906799 (rank : 30)
Query Neighborhood Hits	163	Target Neighborhood Hits	103	Shared Neighborhood Hits	80
SwissProt Accessions	Q6ZMM2, Q8IW95	Gene names	ADAMTSL5, THSD6
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 5 precursor (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6).

ATL2_HUMAN
θ value	5.20228e-48 (rank : 35)	NC score	0.874173 (rank : 34)
Query Neighborhood Hits	163	Target Neighborhood Hits	125	Shared Neighborhood Hits	87
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

CI094_HUMAN
θ value	1.16434e-31 (rank : 36)	NC score	0.593618 (rank : 40)
Query Neighborhood Hits	163	Target Neighborhood Hits	310	Shared Neighborhood Hits	76
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

ADA19_HUMAN
θ value	5.23862e-24 (rank : 37)	NC score	0.565025 (rank : 45)
Query Neighborhood Hits	163	Target Neighborhood Hits	381	Shared Neighborhood Hits	79
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

ADA19_MOUSE
θ value	1.5242e-23 (rank : 38)	NC score	0.573227 (rank : 43)
Query Neighborhood Hits	163	Target Neighborhood Hits	315	Shared Neighborhood Hits	85
SwissProt Accessions	O35674	Gene names	Adam19, Mltnb
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta).

HMCN1_HUMAN
θ value	4.9032e-22 (rank : 39)	NC score	0.297168 (rank : 117)
Query Neighborhood Hits	163	Target Neighborhood Hits	983	Shared Neighborhood Hits	116
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

ADAM9_MOUSE
θ value	1.2077e-20 (rank : 40)	NC score	0.535127 (rank : 52)
Query Neighborhood Hits	163	Target Neighborhood Hits	325	Shared Neighborhood Hits	83
SwissProt Accessions	Q61072, Q60618, Q61853, Q80U94	Gene names	Adam9, Kiaa0021, Mdc9, Mltng
Domain Architecture	No domain graphic available
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma).

ADA12_HUMAN
θ value	2.06002e-20 (rank : 41)	NC score	0.554371 (rank : 48)
Query Neighborhood Hits	163	Target Neighborhood Hits	224	Shared Neighborhood Hits	80
SwissProt Accessions	O43184, O60470	Gene names	ADAM12, MLTN
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

SPON1_MOUSE
θ value	2.06002e-20 (rank : 42)	NC score	0.615790 (rank : 39)
Query Neighborhood Hits	163	Target Neighborhood Hits	123	Shared Neighborhood Hits	91
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

SPON1_HUMAN
θ value	2.69047e-20 (rank : 43)	NC score	0.617472 (rank : 38)
Query Neighborhood Hits	163	Target Neighborhood Hits	117	Shared Neighborhood Hits	89
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

BAI1_MOUSE
θ value	1.33526e-19 (rank : 44)	NC score	0.486559 (rank : 65)
Query Neighborhood Hits	163	Target Neighborhood Hits	340	Shared Neighborhood Hits	88
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI1_HUMAN
θ value	1.74391e-19 (rank : 45)	NC score	0.484623 (rank : 70)
Query Neighborhood Hits	163	Target Neighborhood Hits	375	Shared Neighborhood Hits	87
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

ADAM8_MOUSE
θ value	1.13037e-18 (rank : 46)	NC score	0.573722 (rank : 42)
Query Neighborhood Hits	163	Target Neighborhood Hits	326	Shared Neighborhood Hits	93
SwissProt Accessions	Q05910	Gene names	Adam8, Ms2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (Macrophage cysteine-rich glycoprotein) (CD156 antigen).

ADAM9_HUMAN
θ value	1.92812e-18 (rank : 47)	NC score	0.526211 (rank : 56)
Query Neighborhood Hits	163	Target Neighborhood Hits	243	Shared Neighborhood Hits	83
SwissProt Accessions	Q13443, Q10718, Q8NFM6	Gene names	ADAM9, KIAA0021, MCMP, MDC9, MLTNG
Domain Architecture
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma) (Cellular disintegrin-related protein).

BAI3_MOUSE
θ value	4.29542e-18 (rank : 48)	NC score	0.484154 (rank : 71)
Query Neighborhood Hits	163	Target Neighborhood Hits	250	Shared Neighborhood Hits	90
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

ADA12_MOUSE
θ value	1.24977e-17 (rank : 49)	NC score	0.544670 (rank : 50)
Query Neighborhood Hits	163	Target Neighborhood Hits	474	Shared Neighborhood Hits	81
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

BAI3_HUMAN
θ value	1.24977e-17 (rank : 50)	NC score	0.484627 (rank : 69)
Query Neighborhood Hits	163	Target Neighborhood Hits	246	Shared Neighborhood Hits	86
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

SSPO_MOUSE
θ value	6.20254e-17 (rank : 51)	NC score	0.436416 (rank : 95)
Query Neighborhood Hits	163	Target Neighborhood Hits	800	Shared Neighborhood Hits	137
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

ADAM8_HUMAN
θ value	2.35696e-16 (rank : 52)	NC score	0.574107 (rank : 41)
Query Neighborhood Hits	163	Target Neighborhood Hits	327	Shared Neighborhood Hits	89
SwissProt Accessions	P78325	Gene names	ADAM8, MS2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (CD156a antigen) (CD156).

SEM5A_HUMAN
θ value	4.02038e-16 (rank : 53)	NC score	0.445924 (rank : 89)
Query Neighborhood Hits	163	Target Neighborhood Hits	177	Shared Neighborhood Hits	89
SwissProt Accessions	Q13591, O60408, Q1RLL9	Gene names	SEMA5A, SEMAF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

ADA33_HUMAN
θ value	6.85773e-16 (rank : 54)	NC score	0.554243 (rank : 49)
Query Neighborhood Hits	163	Target Neighborhood Hits	264	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BZ11, Q5JT75, Q5JT76, Q8N0W6	Gene names	ADAM33
Domain Architecture
Description	ADAM 33 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 33).

ADA33_MOUSE
θ value	1.16975e-15 (rank : 55)	NC score	0.528366 (rank : 55)
Query Neighborhood Hits	163	Target Neighborhood Hits	231	Shared Neighborhood Hits	84
SwissProt Accessions	Q923W9	Gene names	Adam33
Domain Architecture
Description	ADAM 33 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 33).

TSP1_HUMAN
θ value	1.16975e-15 (rank : 56)	NC score	0.480177 (rank : 75)
Query Neighborhood Hits	163	Target Neighborhood Hits	389	Shared Neighborhood Hits	104
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

SEM5A_MOUSE
θ value	1.52774e-15 (rank : 57)	NC score	0.436776 (rank : 94)
Query Neighborhood Hits	163	Target Neighborhood Hits	162	Shared Neighborhood Hits	88
SwissProt Accessions	Q62217	Gene names	Sema5a, Semaf, SemF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

BAI2_HUMAN
θ value	1.99529e-15 (rank : 58)	NC score	0.486186 (rank : 66)
Query Neighborhood Hits	163	Target Neighborhood Hits	332	Shared Neighborhood Hits	87
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI2_MOUSE
θ value	2.60593e-15 (rank : 59)	NC score	0.483839 (rank : 72)
Query Neighborhood Hits	163	Target Neighborhood Hits	323	Shared Neighborhood Hits	90
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

TSP2_HUMAN
θ value	3.40345e-15 (rank : 60)	NC score	0.476227 (rank : 83)
Query Neighborhood Hits	163	Target Neighborhood Hits	359	Shared Neighborhood Hits	102
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

SEM5B_MOUSE
θ value	4.44505e-15 (rank : 61)	NC score	0.434099 (rank : 97)
Query Neighborhood Hits	163	Target Neighborhood Hits	190	Shared Neighborhood Hits	88
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

TSP1_MOUSE
θ value	4.44505e-15 (rank : 62)	NC score	0.479247 (rank : 77)
Query Neighborhood Hits	163	Target Neighborhood Hits	396	Shared Neighborhood Hits	106
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

ADA28_MOUSE
θ value	5.8054e-15 (rank : 63)	NC score	0.569710 (rank : 44)
Query Neighborhood Hits	163	Target Neighborhood Hits	241	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JLN6, Q8K5D2, Q8K5D3	Gene names	Adam28
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Thymic epithelial cell-ADAM) (TECADAM).

TSP2_MOUSE
θ value	9.90251e-15 (rank : 64)	NC score	0.478050 (rank : 78)
Query Neighborhood Hits	163	Target Neighborhood Hits	352	Shared Neighborhood Hits	102
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

ADAM7_HUMAN
θ value	3.76295e-14 (rank : 65)	NC score	0.536544 (rank : 51)
Query Neighborhood Hits	163	Target Neighborhood Hits	221	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H2U9, O75959	Gene names	ADAM7, GP83
Domain Architecture
Description	ADAM 7 precursor (A disintegrin and metalloproteinase domain 7) (Sperm maturation-related glycoprotein GP-83).

SEM5B_HUMAN
θ value	3.76295e-14 (rank : 66)	NC score	0.432006 (rank : 100)
Query Neighborhood Hits	163	Target Neighborhood Hits	178	Shared Neighborhood Hits	86
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

ADA28_HUMAN
θ value	8.38298e-14 (rank : 67)	NC score	0.558919 (rank : 46)
Query Neighborhood Hits	163	Target Neighborhood Hits	244	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UKQ2, Q9Y339, Q9Y3S0	Gene names	ADAM28, MDCL
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein-L) (MDC-L) (eMDC II) (ADAM23).

PROP_HUMAN
θ value	8.38298e-14 (rank : 68)	NC score	0.656041 (rank : 36)
Query Neighborhood Hits	163	Target Neighborhood Hits	126	Shared Neighborhood Hits	79
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

PROP_MOUSE
θ value	8.38298e-14 (rank : 69)	NC score	0.650907 (rank : 37)
Query Neighborhood Hits	163	Target Neighborhood Hits	165	Shared Neighborhood Hits	84
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

AD26A_MOUSE
θ value	4.16044e-13 (rank : 70)	NC score	0.477698 (rank : 79)
Query Neighborhood Hits	163	Target Neighborhood Hits	165	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R158	Gene names	Adam26a, Adam26
Domain Architecture
Description	ADAM 26A precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 26A) (Testase-3).

ADA23_MOUSE
θ value	4.16044e-13 (rank : 71)	NC score	0.484640 (rank : 68)
Query Neighborhood Hits	163	Target Neighborhood Hits	245	Shared Neighborhood Hits	81
SwissProt Accessions	Q9R1V7, Q6QDY9, Q6QDZ0, Q8CC33	Gene names	Adam23, Mdc3
Domain Architecture	No domain graphic available
Description	ADAM 23 precursor (A disintegrin and metalloproteinase domain 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3).

ADA15_HUMAN
θ value	3.52202e-12 (rank : 72)	NC score	0.530231 (rank : 54)
Query Neighborhood Hits	163	Target Neighborhood Hits	288	Shared Neighborhood Hits	90
SwissProt Accessions	Q13444, Q13493, Q96C78	Gene names	ADAM15, MDC15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin).

ADA22_HUMAN
θ value	4.59992e-12 (rank : 73)	NC score	0.495669 (rank : 61)
Query Neighborhood Hits	163	Target Neighborhood Hits	211	Shared Neighborhood Hits	80
SwissProt Accessions	Q9P0K1, O75075, O75076, Q9P0K2, Q9UIA1, Q9UKK2	Gene names	ADAM22, MDC2
Domain Architecture
Description	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3).

ADA22_MOUSE
θ value	6.00763e-12 (rank : 74)	NC score	0.486012 (rank : 67)
Query Neighborhood Hits	163	Target Neighborhood Hits	225	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R1V6, Q5TLI8, Q5TLI9, Q5TLJ0, Q5TLJ1, Q5TLJ2, Q5TLJ3, Q5TLJ4, Q5TLJ5, Q5TLJ6, Q5TLJ7, Q5TLJ8, Q5TLJ9, Q5TLK0, Q5TLK1, Q5TLK2, Q5TLK3, Q5TLK4, Q5TLK5, Q5TLK6, Q5TLK7, Q5TLK8, Q8BSF2, Q9R1V5	Gene names	Adam22
Domain Architecture
Description	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22).

ADA24_MOUSE
θ value	6.00763e-12 (rank : 75)	NC score	0.487370 (rank : 64)
Query Neighborhood Hits	163	Target Neighborhood Hits	230	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R160	Gene names	Adam24
Domain Architecture
Description	ADAM 24 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 24) (Testase 1).

ADA25_MOUSE
θ value	2.28291e-11 (rank : 76)	NC score	0.480482 (rank : 74)
Query Neighborhood Hits	163	Target Neighborhood Hits	213	Shared Neighborhood Hits	83
SwissProt Accessions	Q9R159, Q9D4E4	Gene names	Adam25
Domain Architecture
Description	ADAM 25 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 25) (Testase 2).

ADM1B_MOUSE
θ value	2.28291e-11 (rank : 77)	NC score	0.500653 (rank : 59)
Query Neighborhood Hits	163	Target Neighborhood Hits	236	Shared Neighborhood Hits	83
SwissProt Accessions	Q8R534, Q9R156	Gene names	Adam1b
Domain Architecture
Description	ADAM 1b precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 1b) (Fertilin alpha 1b subunit).

ADA23_HUMAN
θ value	3.89403e-11 (rank : 78)	NC score	0.476682 (rank : 82)
Query Neighborhood Hits	163	Target Neighborhood Hits	235	Shared Neighborhood Hits	78
SwissProt Accessions	O75077	Gene names	ADAM23, MDC3
Domain Architecture	No domain graphic available
Description	ADAM 23 precursor (A disintegrin and metalloproteinase domain 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3).

ADEC1_HUMAN
θ value	3.89403e-11 (rank : 79)	NC score	0.556419 (rank : 47)
Query Neighborhood Hits	163	Target Neighborhood Hits	80	Shared Neighborhood Hits	71
SwissProt Accessions	O15204	Gene names	ADAMDEC1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

ADM1A_MOUSE
θ value	1.133e-10 (rank : 80)	NC score	0.492100 (rank : 62)
Query Neighborhood Hits	163	Target Neighborhood Hits	230	Shared Neighborhood Hits	87
SwissProt Accessions	Q60813, Q60617, Q80WR7, Q8R533	Gene names	Adam1a, Adam1, Ftna
Domain Architecture
Description	ADAM 1a precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 1a) (Fertilin alpha 1a subunit).

ADA21_HUMAN
θ value	1.47974e-10 (rank : 81)	NC score	0.477279 (rank : 80)
Query Neighborhood Hits	163	Target Neighborhood Hits	181	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UKJ8, O43507	Gene names	ADAM21
Domain Architecture
Description	ADAM 21 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 21).

ADA21_MOUSE
θ value	1.9326e-10 (rank : 82)	NC score	0.491713 (rank : 63)
Query Neighborhood Hits	163	Target Neighborhood Hits	172	Shared Neighborhood Hits	78
SwissProt Accessions	Q9JI76	Gene names	Adam21, Adam31
Domain Architecture
Description	ADAM 21 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 21) (ADAM 31).

ADAM7_MOUSE
θ value	2.52405e-10 (rank : 83)	NC score	0.534027 (rank : 53)
Query Neighborhood Hits	163	Target Neighborhood Hits	200	Shared Neighborhood Hits	82
SwissProt Accessions	O35227	Gene names	Adam7
Domain Architecture
Description	ADAM 7 precursor (A disintegrin and metalloproteinase domain 7).

ADEC1_MOUSE
θ value	3.29651e-10 (rank : 84)	NC score	0.509179 (rank : 58)
Query Neighborhood Hits	163	Target Neighborhood Hits	85	Shared Neighborhood Hits	72
SwissProt Accessions	Q9R0X2	Gene names	Adamdec1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

ADA29_HUMAN
θ value	5.62301e-10 (rank : 85)	NC score	0.479459 (rank : 76)
Query Neighborhood Hits	163	Target Neighborhood Hits	247	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

ADAM2_MOUSE
θ value	1.25267e-09 (rank : 86)	NC score	0.439529 (rank : 92)
Query Neighborhood Hits	163	Target Neighborhood Hits	209	Shared Neighborhood Hits	81
SwissProt Accessions	Q60718, Q60814, Q9D4G3, Q9QWJ0	Gene names	Adam2, Ftnb
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta).

ADA11_HUMAN
θ value	3.64472e-09 (rank : 87)	NC score	0.440794 (rank : 91)
Query Neighborhood Hits	163	Target Neighborhood Hits	259	Shared Neighborhood Hits	79
SwissProt Accessions	O75078, Q14808, Q14809, Q14810	Gene names	ADAM11, MDC
Domain Architecture
Description	ADAM 11 precursor (A disintegrin and metalloproteinase domain 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).

UNC5C_HUMAN
θ value	2.36244e-08 (rank : 88)	NC score	0.450013 (rank : 88)
Query Neighborhood Hits	163	Target Neighborhood Hits	226	Shared Neighborhood Hits	78
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

UNC5C_MOUSE
θ value	2.36244e-08 (rank : 89)	NC score	0.450452 (rank : 87)
Query Neighborhood Hits	163	Target Neighborhood Hits	225	Shared Neighborhood Hits	78
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UNC5A_MOUSE
θ value	3.08544e-08 (rank : 90)	NC score	0.477152 (rank : 81)
Query Neighborhood Hits	163	Target Neighborhood Hits	203	Shared Neighborhood Hits	76
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

UNC5D_HUMAN
θ value	4.0297e-08 (rank : 91)	NC score	0.441756 (rank : 90)
Query Neighborhood Hits	163	Target Neighborhood Hits	267	Shared Neighborhood Hits	77
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

ADAM2_HUMAN
θ value	6.87365e-08 (rank : 92)	NC score	0.404196 (rank : 107)
Query Neighborhood Hits	163	Target Neighborhood Hits	175	Shared Neighborhood Hits	75
SwissProt Accessions	Q99965, P78326, Q9UQQ8	Gene names	ADAM2, FTNB
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30).

UNC5B_MOUSE
θ value	6.87365e-08 (rank : 93)	NC score	0.466448 (rank : 84)
Query Neighborhood Hits	163	Target Neighborhood Hits	226	Shared Neighborhood Hits	77
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

ADA15_MOUSE
θ value	8.97725e-08 (rank : 94)	NC score	0.499429 (rank : 60)
Query Neighborhood Hits	163	Target Neighborhood Hits	324	Shared Neighborhood Hits	90
SwissProt Accessions	O88839, Q3U7C2, Q8C7Z0, Q91VS9, Q9QYL2	Gene names	Adam15, Mdc15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin) (AD56).

CO8A_HUMAN
θ value	8.97725e-08 (rank : 95)	NC score	0.433565 (rank : 98)
Query Neighborhood Hits	163	Target Neighborhood Hits	200	Shared Neighborhood Hits	71
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

UNC5B_HUMAN
θ value	8.97725e-08 (rank : 96)	NC score	0.464072 (rank : 86)
Query Neighborhood Hits	163	Target Neighborhood Hits	225	Shared Neighborhood Hits	77
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

UNC5D_MOUSE
θ value	8.97725e-08 (rank : 97)	NC score	0.437967 (rank : 93)
Query Neighborhood Hits	163	Target Neighborhood Hits	268	Shared Neighborhood Hits	77
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

ADA11_MOUSE
θ value	1.17247e-07 (rank : 98)	NC score	0.464187 (rank : 85)
Query Neighborhood Hits	163	Target Neighborhood Hits	263	Shared Neighborhood Hits	79
SwissProt Accessions	Q9R1V4	Gene names	Adam11, Mdc
Domain Architecture
Description	ADAM 11 precursor (A disintegrin and metalloproteinase domain 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).

CO8B_HUMAN
θ value	1.17247e-07 (rank : 99)	NC score	0.378180 (rank : 111)
Query Neighborhood Hits	163	Target Neighborhood Hits	199	Shared Neighborhood Hits	66
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

ADA32_HUMAN
θ value	1.53129e-07 (rank : 100)	NC score	0.432826 (rank : 99)
Query Neighborhood Hits	163	Target Neighborhood Hits	216	Shared Neighborhood Hits	80
SwissProt Accessions	Q8TC27, Q8TC42	Gene names	ADAM32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

CO8B_MOUSE
θ value	1.53129e-07 (rank : 101)	NC score	0.412564 (rank : 104)
Query Neighborhood Hits	163	Target Neighborhood Hits	224	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

CILP2_HUMAN
θ value	4.45536e-07 (rank : 102)	NC score	0.406505 (rank : 106)
Query Neighborhood Hits	163	Target Neighborhood Hits	307	Shared Neighborhood Hits	76
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

CO6_HUMAN
θ value	4.45536e-07 (rank : 103)	NC score	0.426302 (rank : 102)
Query Neighborhood Hits	163	Target Neighborhood Hits	331	Shared Neighborhood Hits	80
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

UNC5A_HUMAN
θ value	2.88788e-06 (rank : 104)	NC score	0.385338 (rank : 109)
Query Neighborhood Hits	163	Target Neighborhood Hits	198	Shared Neighborhood Hits	73
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

THSD1_HUMAN
θ value	8.40245e-06 (rank : 105)	NC score	0.516932 (rank : 57)
Query Neighborhood Hits	163	Target Neighborhood Hits	136	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

ADA32_MOUSE
θ value	1.43324e-05 (rank : 106)	NC score	0.429923 (rank : 101)
Query Neighborhood Hits	163	Target Neighborhood Hits	219	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K410, Q6P901, Q8BJ80	Gene names	Adam32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

CO7_HUMAN
θ value	1.43324e-05 (rank : 107)	NC score	0.380621 (rank : 110)
Query Neighborhood Hits	163	Target Neighborhood Hits	278	Shared Neighborhood Hits	71
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

CO8A_MOUSE
θ value	2.44474e-05 (rank : 108)	NC score	0.425100 (rank : 103)
Query Neighborhood Hits	163	Target Neighborhood Hits	182	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K182, Q8CHJ9, Q8CHK1	Gene names	C8a
Domain Architecture	No domain graphic available
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

ADA20_HUMAN
θ value	9.29e-05 (rank : 109)	NC score	0.435858 (rank : 96)
Query Neighborhood Hits	163	Target Neighborhood Hits	143	Shared Neighborhood Hits	79
SwissProt Accessions	O43506, Q9UKJ9	Gene names	ADAM20
Domain Architecture
Description	ADAM 20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 20).

ADA18_MOUSE
θ value	0.00102713 (rank : 110)	NC score	0.411350 (rank : 105)
Query Neighborhood Hits	163	Target Neighborhood Hits	227	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R157, Q60621	Gene names	Adam18, Adam27, Dtgn3, Tmdc3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III) (ADAM 27).

ADA30_HUMAN
θ value	0.00298849 (rank : 111)	NC score	0.377995 (rank : 112)
Query Neighborhood Hits	163	Target Neighborhood Hits	391	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UKF2, Q9UKF1	Gene names	ADAM30
Domain Architecture
Description	ADAM 30 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 30).

KR104_HUMAN
θ value	0.00390308 (rank : 112)	NC score	0.095035 (rank : 132)
Query Neighborhood Hits	163	Target Neighborhood Hits	313	Shared Neighborhood Hits	57
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

ADA18_HUMAN
θ value	0.00509761 (rank : 113)	NC score	0.387176 (rank : 108)
Query Neighborhood Hits	163	Target Neighborhood Hits	184	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y3Q7, Q6UXJ9	Gene names	ADAM18, TMDC3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III).

THSD1_MOUSE
θ value	0.00509761 (rank : 114)	NC score	0.481594 (rank : 73)
Query Neighborhood Hits	163	Target Neighborhood Hits	153	Shared Neighborhood Hits	75
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

KR106_HUMAN
θ value	0.00665767 (rank : 115)	NC score	0.100224 (rank : 129)
Query Neighborhood Hits	163	Target Neighborhood Hits	347	Shared Neighborhood Hits	65
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

KR107_HUMAN
θ value	0.0148317 (rank : 116)	NC score	0.079488 (rank : 140)
Query Neighborhood Hits	163	Target Neighborhood Hits	330	Shared Neighborhood Hits	54
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

CILP1_HUMAN
θ value	0.0961366 (rank : 117)	NC score	0.290874 (rank : 119)
Query Neighborhood Hits	163	Target Neighborhood Hits	266	Shared Neighborhood Hits	77
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

ADA10_HUMAN
θ value	0.163984 (rank : 118)	NC score	0.364715 (rank : 115)
Query Neighborhood Hits	163	Target Neighborhood Hits	189	Shared Neighborhood Hits	80
SwissProt Accessions	O14672, Q10742, Q92650	Gene names	ADAM10, KUZ, MADM
Domain Architecture
Description	ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog) (CDw156c antigen).

ADA10_MOUSE
θ value	0.163984 (rank : 119)	NC score	0.366233 (rank : 114)
Query Neighborhood Hits	163	Target Neighborhood Hits	194	Shared Neighborhood Hits	82
SwissProt Accessions	O35598	Gene names	Adam10, Kuz, Madm
Domain Architecture
Description	ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog).

CILP1_MOUSE
θ value	0.163984 (rank : 120)	NC score	0.292691 (rank : 118)
Query Neighborhood Hits	163	Target Neighborhood Hits	282	Shared Neighborhood Hits	75
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

HGF_HUMAN
θ value	0.21417 (rank : 121)	NC score	0.007165 (rank : 184)
Query Neighborhood Hits	163	Target Neighborhood Hits	191	Shared Neighborhood Hits	6
SwissProt Accessions	P14210, Q02935, Q13494, Q14519, Q8TCE2, Q9BYL9, Q9BYM0, Q9UDU6	Gene names	HGF, HPTA
Domain Architecture
Description	Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain].

HGF_MOUSE
θ value	0.21417 (rank : 122)	NC score	0.007126 (rank : 185)
Query Neighborhood Hits	163	Target Neighborhood Hits	192	Shared Neighborhood Hits	6
SwissProt Accessions	Q08048, Q61662, Q64007, Q6LBE6	Gene names	Hgf
Domain Architecture
Description	Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain].

MBD1_HUMAN
θ value	0.279714 (rank : 123)	NC score	0.013823 (rank : 178)
Query Neighborhood Hits	163	Target Neighborhood Hits	77	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UIS9, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9	Gene names	MBD1, PCM1
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1).

MMP7_MOUSE
θ value	0.47712 (rank : 124)	NC score	0.032718 (rank : 175)
Query Neighborhood Hits	163	Target Neighborhood Hits	60	Shared Neighborhood Hits	21
SwissProt Accessions	Q10738	Gene names	Mmp7
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

WISP1_MOUSE
θ value	0.813845 (rank : 125)	NC score	0.140044 (rank : 122)
Query Neighborhood Hits	163	Target Neighborhood Hits	123	Shared Neighborhood Hits	58
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

WISP2_HUMAN
θ value	0.813845 (rank : 126)	NC score	0.156204 (rank : 120)
Query Neighborhood Hits	163	Target Neighborhood Hits	126	Shared Neighborhood Hits	61
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

ZAN_HUMAN
θ value	0.813845 (rank : 127)	NC score	0.032961 (rank : 174)
Query Neighborhood Hits	163	Target Neighborhood Hits	679	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

CTGF_HUMAN
θ value	1.06291 (rank : 128)	NC score	0.089817 (rank : 134)
Query Neighborhood Hits	163	Target Neighborhood Hits	128	Shared Neighborhood Hits	52
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

CYR61_HUMAN
θ value	1.06291 (rank : 129)	NC score	0.123028 (rank : 124)
Query Neighborhood Hits	163	Target Neighborhood Hits	159	Shared Neighborhood Hits	69
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

GP156_HUMAN
θ value	1.06291 (rank : 130)	NC score	0.010398 (rank : 181)
Query Neighborhood Hits	163	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NFN8, Q86SN6	Gene names	GPR156, GABABL, PGR28
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 156 (GABAB-related G-protein coupled receptor) (G-protein coupled receptor PGR28).

NOV_MOUSE
θ value	1.06291 (rank : 131)	NC score	0.116609 (rank : 125)
Query Neighborhood Hits	163	Target Neighborhood Hits	130	Shared Neighborhood Hits	60
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

ADA17_HUMAN
θ value	1.38821 (rank : 132)	NC score	0.355319 (rank : 116)
Query Neighborhood Hits	163	Target Neighborhood Hits	223	Shared Neighborhood Hits	86
SwissProt Accessions	P78536, O60226	Gene names	ADAM17, CSVP, TACE
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (Snake venom-like protease) (CD156b antigen).

ADA17_MOUSE
θ value	1.38821 (rank : 133)	NC score	0.367826 (rank : 113)
Query Neighborhood Hits	163	Target Neighborhood Hits	201	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z0F8, O88726, Q9R1U4, Q9Z0K3	Gene names	Adam17, Tace
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (CD156b antigen).

WISP1_HUMAN
θ value	1.38821 (rank : 134)	NC score	0.131215 (rank : 123)
Query Neighborhood Hits	163	Target Neighborhood Hits	121	Shared Neighborhood Hits	62
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

FRAS1_MOUSE
θ value	1.81305 (rank : 135)	NC score	0.095259 (rank : 131)
Query Neighborhood Hits	163	Target Neighborhood Hits	747	Shared Neighborhood Hits	97
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

TAB2_HUMAN
θ value	1.81305 (rank : 136)	NC score	0.006651 (rank : 186)
Query Neighborhood Hits	163	Target Neighborhood Hits	169	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NYJ8, O94838, Q6I9W8, Q76N06, Q9UFP7	Gene names	MAP3K7IP2, KIAA0733, TAB2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2).

WISP3_HUMAN
θ value	1.81305 (rank : 137)	NC score	0.115731 (rank : 126)
Query Neighborhood Hits	163	Target Neighborhood Hits	87	Shared Neighborhood Hits	45
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

KR102_HUMAN
θ value	2.36792 (rank : 138)	NC score	0.087983 (rank : 136)
Query Neighborhood Hits	163	Target Neighborhood Hits	264	Shared Neighborhood Hits	51
SwissProt Accessions	P60368, Q70LJ5	Gene names	KRTAP10-2, KAP10.2, KAP18-2, KRTAP10.2, KRTAP18-2, KRTAP18.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-2 (Keratin-associated protein 10.2) (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2).

WISP2_MOUSE
θ value	2.36792 (rank : 139)	NC score	0.155125 (rank : 121)
Query Neighborhood Hits	163	Target Neighborhood Hits	129	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

CYR61_MOUSE
θ value	3.0926 (rank : 140)	NC score	0.106610 (rank : 127)
Query Neighborhood Hits	163	Target Neighborhood Hits	156	Shared Neighborhood Hits	62
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

CTGF_MOUSE
θ value	4.03905 (rank : 141)	NC score	0.094890 (rank : 133)
Query Neighborhood Hits	163	Target Neighborhood Hits	124	Shared Neighborhood Hits	54
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

FUBP2_HUMAN
θ value	4.03905 (rank : 142)	NC score	0.003041 (rank : 188)
Query Neighborhood Hits	163	Target Neighborhood Hits	145	Shared Neighborhood Hits	2
SwissProt Accessions	Q92945, O00301, Q9UNT5, Q9UQH5	Gene names	KHSRP, FUBP2
Domain Architecture
Description	Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75).

KR10A_HUMAN
θ value	4.03905 (rank : 143)	NC score	0.035364 (rank : 172)
Query Neighborhood Hits	163	Target Neighborhood Hits	232	Shared Neighborhood Hits	36
SwissProt Accessions	P60014	Gene names	KRTAP10-10, KAP10.10, KAP18-10, KRTAP10.10, KRTAP18-1, KRTAP18.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-10 (Keratin-associated protein 10.10) (High sulfur keratin-associated protein 10.10) (Keratin-associated protein 18-10) (Keratin-associated protein 18.10).

KR10B_HUMAN
θ value	4.03905 (rank : 144)	NC score	0.060890 (rank : 153)
Query Neighborhood Hits	163	Target Neighborhood Hits	269	Shared Neighborhood Hits	45
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

LPP_MOUSE
θ value	4.03905 (rank : 145)	NC score	0.000256 (rank : 190)
Query Neighborhood Hits	163	Target Neighborhood Hits	247	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BFW7, Q5U407, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101	Gene names	Lpp
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner homolog.

TNF13_HUMAN
θ value	4.03905 (rank : 146)	NC score	0.007642 (rank : 183)
Query Neighborhood Hits	163	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	O75888, Q96HV6, Q9P1M8, Q9P1M9	Gene names	TNFSF13, APRIL, TALL2, ZTNF2
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 13 precursor (A proliferation-inducing ligand) (APRIL) (TNF- and APOL-related leukocyte expressed ligand 2) (TALL-2) (TNF-related death ligand 1) (TRDL-1) (CD256 antigen).

TP4AP_HUMAN
θ value	4.03905 (rank : 147)	NC score	0.010469 (rank : 179)
Query Neighborhood Hits	163	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TEL6, Q96H82, Q9BVB8, Q9H429, Q9UFS6	Gene names	TRPC4AP, C20orf188, TRRP4AP
Domain Architecture	No domain graphic available
Description	Trpc4-associated protein (Short transient receptor potential channel 4-associated protein) (Trp4-associated protein) (TAP1 protein) (TNF- receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS).

TP4AP_MOUSE
θ value	4.03905 (rank : 148)	NC score	0.010447 (rank : 180)
Query Neighborhood Hits	163	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLV2, Q920J6, Q99L03	Gene names	Trpc4ap, Trrp4ap
Domain Architecture	No domain graphic available
Description	Trpc4-associated protein (Trp4-associated protein) (Short transient receptor potential channel 4-associated protein) (TNF-receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS) (TAP1 protein) (Rabex-5/Rin2-interacting protein).

KRA51_HUMAN
θ value	5.27518 (rank : 149)	NC score	0.070327 (rank : 144)
Query Neighborhood Hits	163	Target Neighborhood Hits	288	Shared Neighborhood Hits	62
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA53_HUMAN
θ value	5.27518 (rank : 150)	NC score	0.063102 (rank : 150)
Query Neighborhood Hits	163	Target Neighborhood Hits	331	Shared Neighborhood Hits	56
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

MMP26_HUMAN
θ value	5.27518 (rank : 151)	NC score	0.035327 (rank : 173)
Query Neighborhood Hits	163	Target Neighborhood Hits	56	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NRE1, Q9GZS2, Q9NR87	Gene names	MMP26
Domain Architecture
Description	Matrix metalloproteinase-26 precursor (EC 3.4.24.-) (MMP-26) (Matrilysin-2) (Endometase).

NOV_HUMAN
θ value	5.27518 (rank : 152)	NC score	0.102987 (rank : 128)
Query Neighborhood Hits	163	Target Neighborhood Hits	128	Shared Neighborhood Hits	57
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

SREC_HUMAN
θ value	5.27518 (rank : 153)	NC score	0.043101 (rank : 169)
Query Neighborhood Hits	163	Target Neighborhood Hits	645	Shared Neighborhood Hits	73
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

NOTC3_HUMAN
θ value	6.88961 (rank : 154)	NC score	0.041821 (rank : 170)
Query Neighborhood Hits	163	Target Neighborhood Hits	1062	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

PCSK5_HUMAN
θ value	6.88961 (rank : 155)	NC score	0.024115 (rank : 176)
Query Neighborhood Hits	163	Target Neighborhood Hits	291	Shared Neighborhood Hits	27
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

COASY_HUMAN
θ value	8.99809 (rank : 156)	NC score	0.004166 (rank : 187)
Query Neighborhood Hits	163	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q13057, Q8NBM7, Q8NEW1, Q8WXD4, Q9NRM3	Gene names	COASY
Domain Architecture
Description	Bifunctional coenzyme A synthase (CoA synthase) (NBP) (POV-2) [Includes: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Pantetheine-phosphate adenylyltransferase) (PPAT) (Dephospho-CoA pyrophosphorylase); Dephospho-CoA kinase (EC 2.7.1.24) (DPCK) (Dephosphocoenzyme A kinase) (DPCOAK)].

KRA47_HUMAN
θ value	8.99809 (rank : 157)	NC score	0.039189 (rank : 171)
Query Neighborhood Hits	163	Target Neighborhood Hits	204	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BYR0	Gene names	KRTAP4-7, KAP4.7, KRTAP4.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7).

LYPD5_MOUSE
θ value	8.99809 (rank : 158)	NC score	0.010223 (rank : 182)
Query Neighborhood Hits	163	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D7Z7	Gene names	Lypd5
Domain Architecture	No domain graphic available
Description	Ly6/PLAUR domain-containing protein 5 precursor.

MDM2_HUMAN
θ value	8.99809 (rank : 159)	NC score	0.002675 (rank : 189)
Query Neighborhood Hits	163	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

NID2_MOUSE
θ value	8.99809 (rank : 160)	NC score	0.015221 (rank : 177)
Query Neighborhood Hits	163	Target Neighborhood Hits	338	Shared Neighborhood Hits	18
SwissProt Accessions	O88322	Gene names	Nid2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Entactin-2).

RSPO4_MOUSE
θ value	8.99809 (rank : 161)	NC score	0.088454 (rank : 135)
Query Neighborhood Hits	163	Target Neighborhood Hits	110	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

SPON2_HUMAN
θ value	8.99809 (rank : 162)	NC score	0.096436 (rank : 130)
Query Neighborhood Hits	163	Target Neighborhood Hits	53	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BUD6, Q9ULW1	Gene names	SPON2, DIL1
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1).

UBP42_HUMAN
θ value	8.99809 (rank : 163)	NC score	-0.001892 (rank : 191)
Query Neighborhood Hits	163	Target Neighborhood Hits	445	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

CO9_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.065958 (rank : 148)
Query Neighborhood Hits	163	Target Neighborhood Hits	147	Shared Neighborhood Hits	17
SwissProt Accessions	P02748	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor [Contains: Complement component C9a; Complement component C9b].

CO9_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.073764 (rank : 143)
Query Neighborhood Hits	163	Target Neighborhood Hits	153	Shared Neighborhood Hits	23
SwissProt Accessions	P06683, Q91XA7	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor.

COMP_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.052405 (rank : 164)
Query Neighborhood Hits	163	Target Neighborhood Hits	258	Shared Neighborhood Hits	18
SwissProt Accessions	P49747, O14592, Q16388, Q16389, Q8N4T2	Gene names	COMP
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

COMP_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.051065 (rank : 167)
Query Neighborhood Hits	163	Target Neighborhood Hits	290	Shared Neighborhood Hits	20
SwissProt Accessions	Q9R0G6	Gene names	Comp
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

CRIM1_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.053907 (rank : 162)
Query Neighborhood Hits	163	Target Neighborhood Hits	362	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

FRAS1_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.080492 (rank : 139)
Query Neighborhood Hits	163	Target Neighborhood Hits	759	Shared Neighborhood Hits	94
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

KR101_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.068304 (rank : 146)
Query Neighborhood Hits	163	Target Neighborhood Hits	261	Shared Neighborhood Hits	49
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

KR105_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.052624 (rank : 163)
Query Neighborhood Hits	163	Target Neighborhood Hits	271	Shared Neighborhood Hits	44
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

KR109_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.059579 (rank : 155)
Query Neighborhood Hits	163	Target Neighborhood Hits	226	Shared Neighborhood Hits	34
SwissProt Accessions	P60411, Q70LJ1	Gene names	KRTAP10-9, KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-9 (Keratin-associated protein 10.9) (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9).

KR10C_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.059265 (rank : 157)
Query Neighborhood Hits	163	Target Neighborhood Hits	219	Shared Neighborhood Hits	39
SwissProt Accessions	P60413	Gene names	KRTAP10-12, KAP10.12, KAP18-12, KRTAP10.12, KRTAP18-12, KRTAP18.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-12 (Keratin-associated protein 10.12) (High sulfur keratin-associated protein 10.12) (Keratin-associated protein 18-12) (Keratin-associated protein 18.12).

KRA52_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.051540 (rank : 166)
Query Neighborhood Hits	163	Target Neighborhood Hits	236	Shared Neighborhood Hits	41
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

KRA54_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.058677 (rank : 158)
Query Neighborhood Hits	163	Target Neighborhood Hits	270	Shared Neighborhood Hits	51
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

KRA57_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.058535 (rank : 159)
Query Neighborhood Hits	163	Target Neighborhood Hits	269	Shared Neighborhood Hits	48
SwissProt Accessions	Q6L8G8, Q701N5	Gene names	KRTAP5-7, KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-7 (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) (Keratin-associated protein 5-3) (Keratin-associated protein 5.3).

KRA58_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.061996 (rank : 152)
Query Neighborhood Hits	163	Target Neighborhood Hits	324	Shared Neighborhood Hits	57
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

KRA92_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.069469 (rank : 145)
Query Neighborhood Hits	163	Target Neighborhood Hits	198	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

KRA93_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.067584 (rank : 147)
Query Neighborhood Hits	163	Target Neighborhood Hits	203	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

KRA98_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.074676 (rank : 141)
Query Neighborhood Hits	163	Target Neighborhood Hits	185	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

NFX1_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.057408 (rank : 160)
Query Neighborhood Hits	163	Target Neighborhood Hits	405	Shared Neighborhood Hits	42
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

RSPO1_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.085904 (rank : 137)
Query Neighborhood Hits	163	Target Neighborhood Hits	101	Shared Neighborhood Hits	42
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

RSPO1_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.074268 (rank : 142)
Query Neighborhood Hits	163	Target Neighborhood Hits	85	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

RSPO3_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.060748 (rank : 154)
Query Neighborhood Hits	163	Target Neighborhood Hits	128	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO3_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.054916 (rank : 161)
Query Neighborhood Hits	163	Target Neighborhood Hits	120	Shared Neighborhood Hits	30
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO4_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.062423 (rank : 151)
Query Neighborhood Hits	163	Target Neighborhood Hits	110	Shared Neighborhood Hits	32
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

SPON2_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.082505 (rank : 138)
Query Neighborhood Hits	163	Target Neighborhood Hits	42	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BMS2, Q6SJD8	Gene names	Spon2
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin).

TENX_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.059477 (rank : 156)
Query Neighborhood Hits	163	Target Neighborhood Hits	789	Shared Neighborhood Hits	87
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

TSP3_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.051621 (rank : 165)
Query Neighborhood Hits	163	Target Neighborhood Hits	250	Shared Neighborhood Hits	14
SwissProt Accessions	P49746, Q8WV34	Gene names	THBS3, TSP3
Domain Architecture
Description	Thrombospondin-3 precursor.

TSP3_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.050360 (rank : 168)
Query Neighborhood Hits	163	Target Neighborhood Hits	247	Shared Neighborhood Hits	12
SwissProt Accessions	Q05895, Q6LCE0	Gene names	Thbs3, Tsp3
Domain Architecture
Description	Thrombospondin-3 precursor.

ZAN_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.064014 (rank : 149)
Query Neighborhood Hits	163	Target Neighborhood Hits	808	Shared Neighborhood Hits	88
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

Hits sorted by NC score

ATS18_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	163	Target Neighborhood Hits	163	Shared Neighborhood Hits	163
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS18_HUMAN
NC score	0.997996 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	163	Target Neighborhood Hits	169	Shared Neighborhood Hits	143
SwissProt Accessions	Q8TE60, Q6P4R5, Q6ZWJ9	Gene names	ADAMTS18, ADAMTS21
Domain Architecture
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS16_MOUSE
NC score	0.993195 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	163	Target Neighborhood Hits	179	Shared Neighborhood Hits	136
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS16_HUMAN
NC score	0.993077 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	163	Target Neighborhood Hits	208	Shared Neighborhood Hits	138
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS12_MOUSE
NC score	0.980296 (rank : 5)	θ value	5.00115e-184 (rank : 6)
Query Neighborhood Hits	163	Target Neighborhood Hits	220	Shared Neighborhood Hits	137
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS12_HUMAN
NC score	0.978484 (rank : 6)	θ value	3.82926e-184 (rank : 5)
Query Neighborhood Hits	163	Target Neighborhood Hits	251	Shared Neighborhood Hits	137
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS17_HUMAN
NC score	0.977065 (rank : 7)	θ value	9.19922e-154 (rank : 11)
Query Neighborhood Hits	163	Target Neighborhood Hits	194	Shared Neighborhood Hits	135
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

ATS6_HUMAN
NC score	0.976697 (rank : 8)	θ value	7.76955e-161 (rank : 9)
Query Neighborhood Hits	163	Target Neighborhood Hits	141	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UKP5	Gene names	ADAMTS6
Domain Architecture
Description	ADAMTS-6 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 6) (ADAM-TS 6) (ADAM-TS6).

ATS7_HUMAN
NC score	0.975831 (rank : 9)	θ value	1.05253e-149 (rank : 13)
Query Neighborhood Hits	163	Target Neighborhood Hits	169	Shared Neighborhood Hits	128
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

ATS3_HUMAN
NC score	0.974250 (rank : 10)	θ value	7.54289e-148 (rank : 14)
Query Neighborhood Hits	163	Target Neighborhood Hits	179	Shared Neighborhood Hits	133
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

ATS9_HUMAN
NC score	0.974180 (rank : 11)	θ value	4.6918e-174 (rank : 7)
Query Neighborhood Hits	163	Target Neighborhood Hits	219	Shared Neighborhood Hits	138
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

ATS20_MOUSE
NC score	0.973291 (rank : 12)	θ value	5.19945e-165 (rank : 8)
Query Neighborhood Hits	163	Target Neighborhood Hits	225	Shared Neighborhood Hits	134
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS2_HUMAN
NC score	0.972317 (rank : 13)	θ value	2.12569e-142 (rank : 16)
Query Neighborhood Hits	163	Target Neighborhood Hits	179	Shared Neighborhood Hits	127
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS2_MOUSE
NC score	0.971354 (rank : 14)	θ value	9.87422e-140 (rank : 17)
Query Neighborhood Hits	163	Target Neighborhood Hits	179	Shared Neighborhood Hits	126
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS20_HUMAN
NC score	0.971178 (rank : 15)	θ value	6.80647e-157 (rank : 10)
Query Neighborhood Hits	163	Target Neighborhood Hits	192	Shared Neighborhood Hits	131
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS19_MOUSE
NC score	0.970780 (rank : 16)	θ value	5.9766e-145 (rank : 15)
Query Neighborhood Hits	163	Target Neighborhood Hits	188	Shared Neighborhood Hits	131
SwissProt Accessions	P59509	Gene names	Adamts19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS15_HUMAN
NC score	0.970455 (rank : 17)	θ value	4.5974e-129 (rank : 20)
Query Neighborhood Hits	163	Target Neighborhood Hits	151	Shared Neighborhood Hits	133
SwissProt Accessions	Q8TE58	Gene names	ADAMTS15
Domain Architecture
Description	ADAMTS-15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 15) (ADAM-TS 15) (ADAM-TS15).

ATS19_HUMAN
NC score	0.969993 (rank : 18)	θ value	2.76981e-150 (rank : 12)
Query Neighborhood Hits	163	Target Neighborhood Hits	203	Shared Neighborhood Hits	130
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS1_MOUSE
NC score	0.969556 (rank : 19)	θ value	4.74654e-134 (rank : 18)
Query Neighborhood Hits	163	Target Neighborhood Hits	158	Shared Neighborhood Hits	131
SwissProt Accessions	P97857, O54768	Gene names	Adamts1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1).

ATS1_HUMAN
NC score	0.968643 (rank : 20)	θ value	2.28167e-128 (rank : 21)
Query Neighborhood Hits	163	Target Neighborhood Hits	159	Shared Neighborhood Hits	130
SwissProt Accessions	Q9UHI8, Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80	Gene names	ADAMTS1, KIAA1346, METH1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1) (METH-1).

ATS8_HUMAN
NC score	0.963972 (rank : 21)	θ value	4.93473e-115 (rank : 22)
Query Neighborhood Hits	163	Target Neighborhood Hits	145	Shared Neighborhood Hits	122
SwissProt Accessions	Q9UP79, Q9NZS0	Gene names	ADAMTS8, METH2
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) (METH- 8).

ATS14_HUMAN
NC score	0.963741 (rank : 22)	θ value	5.80223e-132 (rank : 19)
Query Neighborhood Hits	163	Target Neighborhood Hits	382	Shared Neighborhood Hits	130
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

ATS5_MOUSE
NC score	0.962495 (rank : 23)	θ value	1.59114e-105 (rank : 26)
Query Neighborhood Hits	163	Target Neighborhood Hits	147	Shared Neighborhood Hits	121
SwissProt Accessions	Q9R001	Gene names	Adamts5
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (Implantin).

ATS5_HUMAN
NC score	0.959184 (rank : 24)	θ value	2.54029e-103 (rank : 27)
Query Neighborhood Hits	163	Target Neighborhood Hits	141	Shared Neighborhood Hits	119
SwissProt Accessions	Q9UNA0, Q9UKP2	Gene names	ADAMTS5, ADAMTS11, ADMP2
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).

ATS8_MOUSE
NC score	0.957609 (rank : 25)	θ value	2.80211e-110 (rank : 23)
Query Neighborhood Hits	163	Target Neighborhood Hits	139	Shared Neighborhood Hits	116
SwissProt Accessions	P57110	Gene names	Adamts8
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2).

ATS4_MOUSE
NC score	0.951555 (rank : 26)	θ value	8.17181e-102 (rank : 28)
Query Neighborhood Hits	163	Target Neighborhood Hits	145	Shared Neighborhood Hits	117
SwissProt Accessions	Q8BNJ2, Q8K384	Gene names	Adamts4
Domain Architecture	No domain graphic available
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1).

ATS4_HUMAN
NC score	0.950418 (rank : 27)	θ value	2.90646e-99 (rank : 29)
Query Neighborhood Hits	163	Target Neighborhood Hits	138	Shared Neighborhood Hits	113
SwissProt Accessions	O75173, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83	Gene names	ADAMTS4, KIAA0688
Domain Architecture
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1) (ADMP-1).

ATS13_HUMAN
NC score	0.944064 (rank : 28)	θ value	1.39067e-109 (rank : 25)
Query Neighborhood Hits	163	Target Neighborhood Hits	238	Shared Neighborhood Hits	119
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS13_MOUSE
NC score	0.943413 (rank : 29)	θ value	4.77967e-110 (rank : 24)
Query Neighborhood Hits	163	Target Neighborhood Hits	227	Shared Neighborhood Hits	124
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATL5_HUMAN
NC score	0.906799 (rank : 30)	θ value	1.36902e-48 (rank : 34)
Query Neighborhood Hits	163	Target Neighborhood Hits	103	Shared Neighborhood Hits	80
SwissProt Accessions	Q6ZMM2, Q8IW95	Gene names	ADAMTSL5, THSD6
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 5 precursor (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6).

ATL1_HUMAN
NC score	0.905940 (rank : 31)	θ value	4.23606e-66 (rank : 31)
Query Neighborhood Hits	163	Target Neighborhood Hits	93	Shared Neighborhood Hits	85
SwissProt Accessions	Q8N6G6, Q5T708, Q96RW4, Q9BXY3	Gene names	ADAMTSL1, ADAMTSR1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (ADAMTSL-1) (Punctin-1).

ATL1_MOUSE
NC score	0.896490 (rank : 32)	θ value	9.48078e-50 (rank : 32)
Query Neighborhood Hits	163	Target Neighborhood Hits	80	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BLI0	Gene names	Adamtsl1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (Punctin-1).

ATL2_MOUSE
NC score	0.875146 (rank : 33)	θ value	1.36902e-48 (rank : 33)
Query Neighborhood Hits	163	Target Neighborhood Hits	137	Shared Neighborhood Hits	88
SwissProt Accessions	Q7TSK7, Q3U0C8	Gene names	Adamtsl2, Kiaa0605, Tcp1
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2) (TSP1-repeats-containing protein 1) (TCP-1).

ATL2_HUMAN
NC score	0.874173 (rank : 34)	θ value	5.20228e-48 (rank : 35)
Query Neighborhood Hits	163	Target Neighborhood Hits	125	Shared Neighborhood Hits	87
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

ATL3_HUMAN
NC score	0.769611 (rank : 35)	θ value	2.23575e-83 (rank : 30)
Query Neighborhood Hits	163	Target Neighborhood Hits	414	Shared Neighborhood Hits	96
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

PROP_HUMAN
NC score	0.656041 (rank : 36)	θ value	8.38298e-14 (rank : 68)
Query Neighborhood Hits	163	Target Neighborhood Hits	126	Shared Neighborhood Hits	79
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

PROP_MOUSE
NC score	0.650907 (rank : 37)	θ value	8.38298e-14 (rank : 69)
Query Neighborhood Hits	163	Target Neighborhood Hits	165	Shared Neighborhood Hits	84
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

SPON1_HUMAN
NC score	0.617472 (rank : 38)	θ value	2.69047e-20 (rank : 43)
Query Neighborhood Hits	163	Target Neighborhood Hits	117	Shared Neighborhood Hits	89
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

SPON1_MOUSE
NC score	0.615790 (rank : 39)	θ value	2.06002e-20 (rank : 42)
Query Neighborhood Hits	163	Target Neighborhood Hits	123	Shared Neighborhood Hits	91
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

CI094_HUMAN
NC score	0.593618 (rank : 40)	θ value	1.16434e-31 (rank : 36)
Query Neighborhood Hits	163	Target Neighborhood Hits	310	Shared Neighborhood Hits	76
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

ADAM8_HUMAN
NC score	0.574107 (rank : 41)	θ value	2.35696e-16 (rank : 52)
Query Neighborhood Hits	163	Target Neighborhood Hits	327	Shared Neighborhood Hits	89
SwissProt Accessions	P78325	Gene names	ADAM8, MS2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (CD156a antigen) (CD156).

ADAM8_MOUSE
NC score	0.573722 (rank : 42)	θ value	1.13037e-18 (rank : 46)
Query Neighborhood Hits	163	Target Neighborhood Hits	326	Shared Neighborhood Hits	93
SwissProt Accessions	Q05910	Gene names	Adam8, Ms2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (Macrophage cysteine-rich glycoprotein) (CD156 antigen).

ADA19_MOUSE
NC score	0.573227 (rank : 43)	θ value	1.5242e-23 (rank : 38)
Query Neighborhood Hits	163	Target Neighborhood Hits	315	Shared Neighborhood Hits	85
SwissProt Accessions	O35674	Gene names	Adam19, Mltnb
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta).

ADA28_MOUSE
NC score	0.569710 (rank : 44)	θ value	5.8054e-15 (rank : 63)
Query Neighborhood Hits	163	Target Neighborhood Hits	241	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JLN6, Q8K5D2, Q8K5D3	Gene names	Adam28
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Thymic epithelial cell-ADAM) (TECADAM).

ADA19_HUMAN
NC score	0.565025 (rank : 45)	θ value	5.23862e-24 (rank : 37)
Query Neighborhood Hits	163	Target Neighborhood Hits	381	Shared Neighborhood Hits	79
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

ADA28_HUMAN
NC score	0.558919 (rank : 46)	θ value	8.38298e-14 (rank : 67)
Query Neighborhood Hits	163	Target Neighborhood Hits	244	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UKQ2, Q9Y339, Q9Y3S0	Gene names	ADAM28, MDCL
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein-L) (MDC-L) (eMDC II) (ADAM23).

ADEC1_HUMAN
NC score	0.556419 (rank : 47)	θ value	3.89403e-11 (rank : 79)
Query Neighborhood Hits	163	Target Neighborhood Hits	80	Shared Neighborhood Hits	71
SwissProt Accessions	O15204	Gene names	ADAMDEC1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

ADA12_HUMAN
NC score	0.554371 (rank : 48)	θ value	2.06002e-20 (rank : 41)
Query Neighborhood Hits	163	Target Neighborhood Hits	224	Shared Neighborhood Hits	80
SwissProt Accessions	O43184, O60470	Gene names	ADAM12, MLTN
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ADA33_HUMAN
NC score	0.554243 (rank : 49)	θ value	6.85773e-16 (rank : 54)
Query Neighborhood Hits	163	Target Neighborhood Hits	264	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BZ11, Q5JT75, Q5JT76, Q8N0W6	Gene names	ADAM33
Domain Architecture
Description	ADAM 33 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 33).

ADA12_MOUSE
NC score	0.544670 (rank : 50)	θ value	1.24977e-17 (rank : 49)
Query Neighborhood Hits	163	Target Neighborhood Hits	474	Shared Neighborhood Hits	81
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ADAM7_HUMAN
NC score	0.536544 (rank : 51)	θ value	3.76295e-14 (rank : 65)
Query Neighborhood Hits	163	Target Neighborhood Hits	221	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H2U9, O75959	Gene names	ADAM7, GP83
Domain Architecture
Description	ADAM 7 precursor (A disintegrin and metalloproteinase domain 7) (Sperm maturation-related glycoprotein GP-83).

ADAM9_MOUSE
NC score	0.535127 (rank : 52)	θ value	1.2077e-20 (rank : 40)
Query Neighborhood Hits	163	Target Neighborhood Hits	325	Shared Neighborhood Hits	83
SwissProt Accessions	Q61072, Q60618, Q61853, Q80U94	Gene names	Adam9, Kiaa0021, Mdc9, Mltng
Domain Architecture	No domain graphic available
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma).

ADAM7_MOUSE
NC score	0.534027 (rank : 53)	θ value	2.52405e-10 (rank : 83)
Query Neighborhood Hits	163	Target Neighborhood Hits	200	Shared Neighborhood Hits	82
SwissProt Accessions	O35227	Gene names	Adam7
Domain Architecture
Description	ADAM 7 precursor (A disintegrin and metalloproteinase domain 7).

ADA15_HUMAN
NC score	0.530231 (rank : 54)	θ value	3.52202e-12 (rank : 72)
Query Neighborhood Hits	163	Target Neighborhood Hits	288	Shared Neighborhood Hits	90
SwissProt Accessions	Q13444, Q13493, Q96C78	Gene names	ADAM15, MDC15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin).

ADA33_MOUSE
NC score	0.528366 (rank : 55)	θ value	1.16975e-15 (rank : 55)
Query Neighborhood Hits	163	Target Neighborhood Hits	231	Shared Neighborhood Hits	84
SwissProt Accessions	Q923W9	Gene names	Adam33
Domain Architecture
Description	ADAM 33 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 33).

ADAM9_HUMAN
NC score	0.526211 (rank : 56)	θ value	1.92812e-18 (rank : 47)
Query Neighborhood Hits	163	Target Neighborhood Hits	243	Shared Neighborhood Hits	83
SwissProt Accessions	Q13443, Q10718, Q8NFM6	Gene names	ADAM9, KIAA0021, MCMP, MDC9, MLTNG
Domain Architecture
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma) (Cellular disintegrin-related protein).

THSD1_HUMAN
NC score	0.516932 (rank : 57)	θ value	8.40245e-06 (rank : 105)
Query Neighborhood Hits	163	Target Neighborhood Hits	136	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

ADEC1_MOUSE
NC score	0.509179 (rank : 58)	θ value	3.29651e-10 (rank : 84)
Query Neighborhood Hits	163	Target Neighborhood Hits	85	Shared Neighborhood Hits	72
SwissProt Accessions	Q9R0X2	Gene names	Adamdec1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

ADM1B_MOUSE
NC score	0.500653 (rank : 59)	θ value	2.28291e-11 (rank : 77)
Query Neighborhood Hits	163	Target Neighborhood Hits	236	Shared Neighborhood Hits	83
SwissProt Accessions	Q8R534, Q9R156	Gene names	Adam1b
Domain Architecture
Description	ADAM 1b precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 1b) (Fertilin alpha 1b subunit).

ADA15_MOUSE
NC score	0.499429 (rank : 60)	θ value	8.97725e-08 (rank : 94)
Query Neighborhood Hits	163	Target Neighborhood Hits	324	Shared Neighborhood Hits	90
SwissProt Accessions	O88839, Q3U7C2, Q8C7Z0, Q91VS9, Q9QYL2	Gene names	Adam15, Mdc15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin) (AD56).

ADA22_HUMAN
NC score	0.495669 (rank : 61)	θ value	4.59992e-12 (rank : 73)
Query Neighborhood Hits	163	Target Neighborhood Hits	211	Shared Neighborhood Hits	80
SwissProt Accessions	Q9P0K1, O75075, O75076, Q9P0K2, Q9UIA1, Q9UKK2	Gene names	ADAM22, MDC2
Domain Architecture
Description	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3).

ADM1A_MOUSE
NC score	0.492100 (rank : 62)	θ value	1.133e-10 (rank : 80)
Query Neighborhood Hits	163	Target Neighborhood Hits	230	Shared Neighborhood Hits	87
SwissProt Accessions	Q60813, Q60617, Q80WR7, Q8R533	Gene names	Adam1a, Adam1, Ftna
Domain Architecture
Description	ADAM 1a precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 1a) (Fertilin alpha 1a subunit).

ADA21_MOUSE
NC score	0.491713 (rank : 63)	θ value	1.9326e-10 (rank : 82)
Query Neighborhood Hits	163	Target Neighborhood Hits	172	Shared Neighborhood Hits	78
SwissProt Accessions	Q9JI76	Gene names	Adam21, Adam31
Domain Architecture
Description	ADAM 21 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 21) (ADAM 31).

ADA24_MOUSE
NC score	0.487370 (rank : 64)	θ value	6.00763e-12 (rank : 75)
Query Neighborhood Hits	163	Target Neighborhood Hits	230	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R160	Gene names	Adam24
Domain Architecture
Description	ADAM 24 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 24) (Testase 1).

BAI1_MOUSE
NC score	0.486559 (rank : 65)	θ value	1.33526e-19 (rank : 44)
Query Neighborhood Hits	163	Target Neighborhood Hits	340	Shared Neighborhood Hits	88
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI2_HUMAN
NC score	0.486186 (rank : 66)	θ value	1.99529e-15 (rank : 58)
Query Neighborhood Hits	163	Target Neighborhood Hits	332	Shared Neighborhood Hits	87
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

ADA22_MOUSE
NC score	0.486012 (rank : 67)	θ value	6.00763e-12 (rank : 74)
Query Neighborhood Hits	163	Target Neighborhood Hits	225	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R1V6, Q5TLI8, Q5TLI9, Q5TLJ0, Q5TLJ1, Q5TLJ2, Q5TLJ3, Q5TLJ4, Q5TLJ5, Q5TLJ6, Q5TLJ7, Q5TLJ8, Q5TLJ9, Q5TLK0, Q5TLK1, Q5TLK2, Q5TLK3, Q5TLK4, Q5TLK5, Q5TLK6, Q5TLK7, Q5TLK8, Q8BSF2, Q9R1V5	Gene names	Adam22
Domain Architecture
Description	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22).

ADA23_MOUSE
NC score	0.484640 (rank : 68)	θ value	4.16044e-13 (rank : 71)
Query Neighborhood Hits	163	Target Neighborhood Hits	245	Shared Neighborhood Hits	81
SwissProt Accessions	Q9R1V7, Q6QDY9, Q6QDZ0, Q8CC33	Gene names	Adam23, Mdc3
Domain Architecture	No domain graphic available
Description	ADAM 23 precursor (A disintegrin and metalloproteinase domain 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3).

BAI3_HUMAN
NC score	0.484627 (rank : 69)	θ value	1.24977e-17 (rank : 50)
Query Neighborhood Hits	163	Target Neighborhood Hits	246	Shared Neighborhood Hits	86
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BAI1_HUMAN
NC score	0.484623 (rank : 70)	θ value	1.74391e-19 (rank : 45)
Query Neighborhood Hits	163	Target Neighborhood Hits	375	Shared Neighborhood Hits	87
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI3_MOUSE
NC score	0.484154 (rank : 71)	θ value	4.29542e-18 (rank : 48)
Query Neighborhood Hits	163	Target Neighborhood Hits	250	Shared Neighborhood Hits	90
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BAI2_MOUSE
NC score	0.483839 (rank : 72)	θ value	2.60593e-15 (rank : 59)
Query Neighborhood Hits	163	Target Neighborhood Hits	323	Shared Neighborhood Hits	90
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

THSD1_MOUSE
NC score	0.481594 (rank : 73)	θ value	0.00509761 (rank : 114)
Query Neighborhood Hits	163	Target Neighborhood Hits	153	Shared Neighborhood Hits	75
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

ADA25_MOUSE
NC score	0.480482 (rank : 74)	θ value	2.28291e-11 (rank : 76)
Query Neighborhood Hits	163	Target Neighborhood Hits	213	Shared Neighborhood Hits	83
SwissProt Accessions	Q9R159, Q9D4E4	Gene names	Adam25
Domain Architecture
Description	ADAM 25 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 25) (Testase 2).

TSP1_HUMAN
NC score	0.480177 (rank : 75)	θ value	1.16975e-15 (rank : 56)
Query Neighborhood Hits	163	Target Neighborhood Hits	389	Shared Neighborhood Hits	104
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

ADA29_HUMAN
NC score	0.479459 (rank : 76)	θ value	5.62301e-10 (rank : 85)
Query Neighborhood Hits	163	Target Neighborhood Hits	247	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

TSP1_MOUSE
NC score	0.479247 (rank : 77)	θ value	4.44505e-15 (rank : 62)
Query Neighborhood Hits	163	Target Neighborhood Hits	396	Shared Neighborhood Hits	106
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP2_MOUSE
NC score	0.478050 (rank : 78)	θ value	9.90251e-15 (rank : 64)
Query Neighborhood Hits	163	Target Neighborhood Hits	352	Shared Neighborhood Hits	102
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

AD26A_MOUSE
NC score	0.477698 (rank : 79)	θ value	4.16044e-13 (rank : 70)
Query Neighborhood Hits	163	Target Neighborhood Hits	165	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R158	Gene names	Adam26a, Adam26
Domain Architecture
Description	ADAM 26A precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 26A) (Testase-3).

ADA21_HUMAN
NC score	0.477279 (rank : 80)	θ value	1.47974e-10 (rank : 81)
Query Neighborhood Hits	163	Target Neighborhood Hits	181	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UKJ8, O43507	Gene names	ADAM21
Domain Architecture
Description	ADAM 21 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 21).

UNC5A_MOUSE
NC score	0.477152 (rank : 81)	θ value	3.08544e-08 (rank : 90)
Query Neighborhood Hits	163	Target Neighborhood Hits	203	Shared Neighborhood Hits	76
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

ADA23_HUMAN
NC score	0.476682 (rank : 82)	θ value	3.89403e-11 (rank : 78)
Query Neighborhood Hits	163	Target Neighborhood Hits	235	Shared Neighborhood Hits	78
SwissProt Accessions	O75077	Gene names	ADAM23, MDC3
Domain Architecture	No domain graphic available
Description	ADAM 23 precursor (A disintegrin and metalloproteinase domain 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3).

TSP2_HUMAN
NC score	0.476227 (rank : 83)	θ value	3.40345e-15 (rank : 60)
Query Neighborhood Hits	163	Target Neighborhood Hits	359	Shared Neighborhood Hits	102
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

UNC5B_MOUSE
NC score	0.466448 (rank : 84)	θ value	6.87365e-08 (rank : 93)
Query Neighborhood Hits	163	Target Neighborhood Hits	226	Shared Neighborhood Hits	77
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

ADA11_MOUSE
NC score	0.464187 (rank : 85)	θ value	1.17247e-07 (rank : 98)
Query Neighborhood Hits	163	Target Neighborhood Hits	263	Shared Neighborhood Hits	79
SwissProt Accessions	Q9R1V4	Gene names	Adam11, Mdc
Domain Architecture
Description	ADAM 11 precursor (A disintegrin and metalloproteinase domain 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).

UNC5B_HUMAN
NC score	0.464072 (rank : 86)	θ value	8.97725e-08 (rank : 96)
Query Neighborhood Hits	163	Target Neighborhood Hits	225	Shared Neighborhood Hits	77
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

UNC5C_MOUSE
NC score	0.450452 (rank : 87)	θ value	2.36244e-08 (rank : 89)
Query Neighborhood Hits	163	Target Neighborhood Hits	225	Shared Neighborhood Hits	78
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UNC5C_HUMAN
NC score	0.450013 (rank : 88)	θ value	2.36244e-08 (rank : 88)
Query Neighborhood Hits	163	Target Neighborhood Hits	226	Shared Neighborhood Hits	78
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

SEM5A_HUMAN
NC score	0.445924 (rank : 89)	θ value	4.02038e-16 (rank : 53)
Query Neighborhood Hits	163	Target Neighborhood Hits	177	Shared Neighborhood Hits	89
SwissProt Accessions	Q13591, O60408, Q1RLL9	Gene names	SEMA5A, SEMAF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

UNC5D_HUMAN
NC score	0.441756 (rank : 90)	θ value	4.0297e-08 (rank : 91)
Query Neighborhood Hits	163	Target Neighborhood Hits	267	Shared Neighborhood Hits	77
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

ADA11_HUMAN
NC score	0.440794 (rank : 91)	θ value	3.64472e-09 (rank : 87)
Query Neighborhood Hits	163	Target Neighborhood Hits	259	Shared Neighborhood Hits	79
SwissProt Accessions	O75078, Q14808, Q14809, Q14810	Gene names	ADAM11, MDC
Domain Architecture
Description	ADAM 11 precursor (A disintegrin and metalloproteinase domain 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).

ADAM2_MOUSE
NC score	0.439529 (rank : 92)	θ value	1.25267e-09 (rank : 86)
Query Neighborhood Hits	163	Target Neighborhood Hits	209	Shared Neighborhood Hits	81
SwissProt Accessions	Q60718, Q60814, Q9D4G3, Q9QWJ0	Gene names	Adam2, Ftnb
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta).

UNC5D_MOUSE
NC score	0.437967 (rank : 93)	θ value	8.97725e-08 (rank : 97)
Query Neighborhood Hits	163	Target Neighborhood Hits	268	Shared Neighborhood Hits	77
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

SEM5A_MOUSE
NC score	0.436776 (rank : 94)	θ value	1.52774e-15 (rank : 57)
Query Neighborhood Hits	163	Target Neighborhood Hits	162	Shared Neighborhood Hits	88
SwissProt Accessions	Q62217	Gene names	Sema5a, Semaf, SemF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

SSPO_MOUSE
NC score	0.436416 (rank : 95)	θ value	6.20254e-17 (rank : 51)
Query Neighborhood Hits	163	Target Neighborhood Hits	800	Shared Neighborhood Hits	137
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

ADA20_HUMAN
NC score	0.435858 (rank : 96)	θ value	9.29e-05 (rank : 109)
Query Neighborhood Hits	163	Target Neighborhood Hits	143	Shared Neighborhood Hits	79
SwissProt Accessions	O43506, Q9UKJ9	Gene names	ADAM20
Domain Architecture
Description	ADAM 20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 20).

SEM5B_MOUSE
NC score	0.434099 (rank : 97)	θ value	4.44505e-15 (rank : 61)
Query Neighborhood Hits	163	Target Neighborhood Hits	190	Shared Neighborhood Hits	88
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

CO8A_HUMAN
NC score	0.433565 (rank : 98)	θ value	8.97725e-08 (rank : 95)
Query Neighborhood Hits	163	Target Neighborhood Hits	200	Shared Neighborhood Hits	71
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

ADA32_HUMAN
NC score	0.432826 (rank : 99)	θ value	1.53129e-07 (rank : 100)
Query Neighborhood Hits	163	Target Neighborhood Hits	216	Shared Neighborhood Hits	80
SwissProt Accessions	Q8TC27, Q8TC42	Gene names	ADAM32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

SEM5B_HUMAN
NC score	0.432006 (rank : 100)	θ value	3.76295e-14 (rank : 66)
Query Neighborhood Hits	163	Target Neighborhood Hits	178	Shared Neighborhood Hits	86
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

ADA32_MOUSE
NC score	0.429923 (rank : 101)	θ value	1.43324e-05 (rank : 106)
Query Neighborhood Hits	163	Target Neighborhood Hits	219	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K410, Q6P901, Q8BJ80	Gene names	Adam32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

CO6_HUMAN
NC score	0.426302 (rank : 102)	θ value	4.45536e-07 (rank : 103)
Query Neighborhood Hits	163	Target Neighborhood Hits	331	Shared Neighborhood Hits	80
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

CO8A_MOUSE
NC score	0.425100 (rank : 103)	θ value	2.44474e-05 (rank : 108)
Query Neighborhood Hits	163	Target Neighborhood Hits	182	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K182, Q8CHJ9, Q8CHK1	Gene names	C8a
Domain Architecture	No domain graphic available
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

CO8B_MOUSE
NC score	0.412564 (rank : 104)	θ value	1.53129e-07 (rank : 101)
Query Neighborhood Hits	163	Target Neighborhood Hits	224	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

ADA18_MOUSE
NC score	0.411350 (rank : 105)	θ value	0.00102713 (rank : 110)
Query Neighborhood Hits	163	Target Neighborhood Hits	227	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R157, Q60621	Gene names	Adam18, Adam27, Dtgn3, Tmdc3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III) (ADAM 27).

CILP2_HUMAN
NC score	0.406505 (rank : 106)	θ value	4.45536e-07 (rank : 102)
Query Neighborhood Hits	163	Target Neighborhood Hits	307	Shared Neighborhood Hits	76
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

ADAM2_HUMAN
NC score	0.404196 (rank : 107)	θ value	6.87365e-08 (rank : 92)
Query Neighborhood Hits	163	Target Neighborhood Hits	175	Shared Neighborhood Hits	75
SwissProt Accessions	Q99965, P78326, Q9UQQ8	Gene names	ADAM2, FTNB
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30).

ADA18_HUMAN
NC score	0.387176 (rank : 108)	θ value	0.00509761 (rank : 113)
Query Neighborhood Hits	163	Target Neighborhood Hits	184	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y3Q7, Q6UXJ9	Gene names	ADAM18, TMDC3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III).

UNC5A_HUMAN
NC score	0.385338 (rank : 109)	θ value	2.88788e-06 (rank : 104)
Query Neighborhood Hits	163	Target Neighborhood Hits	198	Shared Neighborhood Hits	73
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

CO7_HUMAN
NC score	0.380621 (rank : 110)	θ value	1.43324e-05 (rank : 107)
Query Neighborhood Hits	163	Target Neighborhood Hits	278	Shared Neighborhood Hits	71
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

CO8B_HUMAN
NC score	0.378180 (rank : 111)	θ value	1.17247e-07 (rank : 99)
Query Neighborhood Hits	163	Target Neighborhood Hits	199	Shared Neighborhood Hits	66
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

ADA30_HUMAN
NC score	0.377995 (rank : 112)	θ value	0.00298849 (rank : 111)
Query Neighborhood Hits	163	Target Neighborhood Hits	391	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UKF2, Q9UKF1	Gene names	ADAM30
Domain Architecture
Description	ADAM 30 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 30).

ADA17_MOUSE
NC score	0.367826 (rank : 113)	θ value	1.38821 (rank : 133)
Query Neighborhood Hits	163	Target Neighborhood Hits	201	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z0F8, O88726, Q9R1U4, Q9Z0K3	Gene names	Adam17, Tace
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (CD156b antigen).

ADA10_MOUSE
NC score	0.366233 (rank : 114)	θ value	0.163984 (rank : 119)
Query Neighborhood Hits	163	Target Neighborhood Hits	194	Shared Neighborhood Hits	82
SwissProt Accessions	O35598	Gene names	Adam10, Kuz, Madm
Domain Architecture
Description	ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog).

ADA10_HUMAN
NC score	0.364715 (rank : 115)	θ value	0.163984 (rank : 118)
Query Neighborhood Hits	163	Target Neighborhood Hits	189	Shared Neighborhood Hits	80
SwissProt Accessions	O14672, Q10742, Q92650	Gene names	ADAM10, KUZ, MADM
Domain Architecture
Description	ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog) (CDw156c antigen).

ADA17_HUMAN
NC score	0.355319 (rank : 116)	θ value	1.38821 (rank : 132)
Query Neighborhood Hits	163	Target Neighborhood Hits	223	Shared Neighborhood Hits	86
SwissProt Accessions	P78536, O60226	Gene names	ADAM17, CSVP, TACE
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (Snake venom-like protease) (CD156b antigen).

HMCN1_HUMAN
NC score	0.297168 (rank : 117)	θ value	4.9032e-22 (rank : 39)
Query Neighborhood Hits	163	Target Neighborhood Hits	983	Shared Neighborhood Hits	116
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

CILP1_MOUSE
NC score	0.292691 (rank : 118)	θ value	0.163984 (rank : 120)
Query Neighborhood Hits	163	Target Neighborhood Hits	282	Shared Neighborhood Hits	75
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

CILP1_HUMAN
NC score	0.290874 (rank : 119)	θ value	0.0961366 (rank : 117)
Query Neighborhood Hits	163	Target Neighborhood Hits	266	Shared Neighborhood Hits	77
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

WISP2_HUMAN
NC score	0.156204 (rank : 120)	θ value	0.813845 (rank : 126)
Query Neighborhood Hits	163	Target Neighborhood Hits	126	Shared Neighborhood Hits	61
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

WISP2_MOUSE
NC score	0.155125 (rank : 121)	θ value	2.36792 (rank : 139)
Query Neighborhood Hits	163	Target Neighborhood Hits	129	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

WISP1_MOUSE
NC score	0.140044 (rank : 122)	θ value	0.813845 (rank : 125)
Query Neighborhood Hits	163	Target Neighborhood Hits	123	Shared Neighborhood Hits	58
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

WISP1_HUMAN
NC score	0.131215 (rank : 123)	θ value	1.38821 (rank : 134)
Query Neighborhood Hits	163	Target Neighborhood Hits	121	Shared Neighborhood Hits	62
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

CYR61_HUMAN
NC score	0.123028 (rank : 124)	θ value	1.06291 (rank : 129)
Query Neighborhood Hits	163	Target Neighborhood Hits	159	Shared Neighborhood Hits	69
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

NOV_MOUSE
NC score	0.116609 (rank : 125)	θ value	1.06291 (rank : 131)
Query Neighborhood Hits	163	Target Neighborhood Hits	130	Shared Neighborhood Hits	60
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

WISP3_HUMAN
NC score	0.115731 (rank : 126)	θ value	1.81305 (rank : 137)
Query Neighborhood Hits	163	Target Neighborhood Hits	87	Shared Neighborhood Hits	45
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

CYR61_MOUSE
NC score	0.106610 (rank : 127)	θ value	3.0926 (rank : 140)
Query Neighborhood Hits	163	Target Neighborhood Hits	156	Shared Neighborhood Hits	62
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

NOV_HUMAN
NC score	0.102987 (rank : 128)	θ value	5.27518 (rank : 152)
Query Neighborhood Hits	163	Target Neighborhood Hits	128	Shared Neighborhood Hits	57
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

KR106_HUMAN
NC score	0.100224 (rank : 129)	θ value	0.00665767 (rank : 115)
Query Neighborhood Hits	163	Target Neighborhood Hits	347	Shared Neighborhood Hits	65
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

SPON2_HUMAN
NC score	0.096436 (rank : 130)	θ value	8.99809 (rank : 162)
Query Neighborhood Hits	163	Target Neighborhood Hits	53	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BUD6, Q9ULW1	Gene names	SPON2, DIL1
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1).

FRAS1_MOUSE
NC score	0.095259 (rank : 131)	θ value	1.81305 (rank : 135)
Query Neighborhood Hits	163	Target Neighborhood Hits	747	Shared Neighborhood Hits	97
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

KR104_HUMAN
NC score	0.095035 (rank : 132)	θ value	0.00390308 (rank : 112)
Query Neighborhood Hits	163	Target Neighborhood Hits	313	Shared Neighborhood Hits	57
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

CTGF_MOUSE
NC score	0.094890 (rank : 133)	θ value	4.03905 (rank : 141)
Query Neighborhood Hits	163	Target Neighborhood Hits	124	Shared Neighborhood Hits	54
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

CTGF_HUMAN
NC score	0.089817 (rank : 134)	θ value	1.06291 (rank : 128)
Query Neighborhood Hits	163	Target Neighborhood Hits	128	Shared Neighborhood Hits	52
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

RSPO4_MOUSE
NC score	0.088454 (rank : 135)	θ value	8.99809 (rank : 161)
Query Neighborhood Hits	163	Target Neighborhood Hits	110	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

KR102_HUMAN
NC score	0.087983 (rank : 136)	θ value	2.36792 (rank : 138)
Query Neighborhood Hits	163	Target Neighborhood Hits	264	Shared Neighborhood Hits	51
SwissProt Accessions	P60368, Q70LJ5	Gene names	KRTAP10-2, KAP10.2, KAP18-2, KRTAP10.2, KRTAP18-2, KRTAP18.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-2 (Keratin-associated protein 10.2) (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2).

RSPO1_HUMAN
NC score	0.085904 (rank : 137)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	163	Target Neighborhood Hits	101	Shared Neighborhood Hits	42
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

SPON2_MOUSE
NC score	0.082505 (rank : 138)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	163	Target Neighborhood Hits	42	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BMS2, Q6SJD8	Gene names	Spon2
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin).

FRAS1_HUMAN
NC score	0.080492 (rank : 139)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	163	Target Neighborhood Hits	759	Shared Neighborhood Hits	94
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

KR107_HUMAN
NC score	0.079488 (rank : 140)	θ value	0.0148317 (rank : 116)
Query Neighborhood Hits	163	Target Neighborhood Hits	330	Shared Neighborhood Hits	54
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

KRA98_HUMAN
NC score	0.074676 (rank : 141)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	163	Target Neighborhood Hits	185	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

RSPO1_MOUSE
NC score	0.074268 (rank : 142)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	163	Target Neighborhood Hits	85	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

CO9_MOUSE
NC score	0.073764 (rank : 143)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	163	Target Neighborhood Hits	153	Shared Neighborhood Hits	23
SwissProt Accessions	P06683, Q91XA7	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor.

KRA51_HUMAN
NC score	0.070327 (rank : 144)	θ value	5.27518 (rank : 149)
Query Neighborhood Hits	163	Target Neighborhood Hits	288	Shared Neighborhood Hits	62
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA92_HUMAN
NC score	0.069469 (rank : 145)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	163	Target Neighborhood Hits	198	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

KR101_HUMAN
NC score	0.068304 (rank : 146)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	163	Target Neighborhood Hits	261	Shared Neighborhood Hits	49
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

KRA93_HUMAN
NC score	0.067584 (rank : 147)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	163	Target Neighborhood Hits	203	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

CO9_HUMAN
NC score	0.065958 (rank : 148)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	163	Target Neighborhood Hits	147	Shared Neighborhood Hits	17
SwissProt Accessions	P02748	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor [Contains: Complement component C9a; Complement component C9b].

ZAN_MOUSE
NC score	0.064014 (rank : 149)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	163	Target Neighborhood Hits	808	Shared Neighborhood Hits	88
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

KRA53_HUMAN
NC score	0.063102 (rank : 150)	θ value	5.27518 (rank : 150)
Query Neighborhood Hits	163	Target Neighborhood Hits	331	Shared Neighborhood Hits	56
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

RSPO4_HUMAN
NC score	0.062423 (rank : 151)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	163	Target Neighborhood Hits	110	Shared Neighborhood Hits	32
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

KRA58_HUMAN
NC score	0.061996 (rank : 152)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	163	Target Neighborhood Hits	324	Shared Neighborhood Hits	57
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

KR10B_HUMAN
NC score	0.060890 (rank : 153)	θ value	4.03905 (rank : 144)
Query Neighborhood Hits	163	Target Neighborhood Hits	269	Shared Neighborhood Hits	45
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

RSPO3_HUMAN
NC score	0.060748 (rank : 154)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	163	Target Neighborhood Hits	128	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

KR109_HUMAN
NC score	0.059579 (rank : 155)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	163	Target Neighborhood Hits	226	Shared Neighborhood Hits	34
SwissProt Accessions	P60411, Q70LJ1	Gene names	KRTAP10-9, KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-9 (Keratin-associated protein 10.9) (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9).

TENX_HUMAN
NC score	0.059477 (rank : 156)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	163	Target Neighborhood Hits	789	Shared Neighborhood Hits	87
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

KR10C_HUMAN
NC score	0.059265 (rank : 157)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	163	Target Neighborhood Hits	219	Shared Neighborhood Hits	39
SwissProt Accessions	P60413	Gene names	KRTAP10-12, KAP10.12, KAP18-12, KRTAP10.12, KRTAP18-12, KRTAP18.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-12 (Keratin-associated protein 10.12) (High sulfur keratin-associated protein 10.12) (Keratin-associated protein 18-12) (Keratin-associated protein 18.12).

KRA54_HUMAN
NC score	0.058677 (rank : 158)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	163	Target Neighborhood Hits	270	Shared Neighborhood Hits	51
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

KRA57_HUMAN
NC score	0.058535 (rank : 159)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	163	Target Neighborhood Hits	269	Shared Neighborhood Hits	48
SwissProt Accessions	Q6L8G8, Q701N5	Gene names	KRTAP5-7, KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-7 (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) (Keratin-associated protein 5-3) (Keratin-associated protein 5.3).

NFX1_HUMAN
NC score	0.057408 (rank : 160)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	163	Target Neighborhood Hits	405	Shared Neighborhood Hits	42
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

RSPO3_MOUSE
NC score	0.054916 (rank : 161)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	163	Target Neighborhood Hits	120	Shared Neighborhood Hits	30
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

CRIM1_HUMAN
NC score	0.053907 (rank : 162)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	163	Target Neighborhood Hits	362	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

KR105_HUMAN
NC score	0.052624 (rank : 163)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	163	Target Neighborhood Hits	271	Shared Neighborhood Hits	44
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

COMP_HUMAN
NC score	0.052405 (rank : 164)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	163	Target Neighborhood Hits	258	Shared Neighborhood Hits	18
SwissProt Accessions	P49747, O14592, Q16388, Q16389, Q8N4T2	Gene names	COMP
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

TSP3_HUMAN
NC score	0.051621 (rank : 165)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	163	Target Neighborhood Hits	250	Shared Neighborhood Hits	14
SwissProt Accessions	P49746, Q8WV34	Gene names	THBS3, TSP3
Domain Architecture
Description	Thrombospondin-3 precursor.

KRA52_HUMAN
NC score	0.051540 (rank : 166)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	163	Target Neighborhood Hits	236	Shared Neighborhood Hits	41
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

COMP_MOUSE
NC score	0.051065 (rank : 167)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	163	Target Neighborhood Hits	290	Shared Neighborhood Hits	20
SwissProt Accessions	Q9R0G6	Gene names	Comp
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

TSP3_MOUSE
NC score	0.050360 (rank : 168)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	163	Target Neighborhood Hits	247	Shared Neighborhood Hits	12
SwissProt Accessions	Q05895, Q6LCE0	Gene names	Thbs3, Tsp3
Domain Architecture
Description	Thrombospondin-3 precursor.

SREC_HUMAN
NC score	0.043101 (rank : 169)	θ value	5.27518 (rank : 153)
Query Neighborhood Hits	163	Target Neighborhood Hits	645	Shared Neighborhood Hits	73
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

NOTC3_HUMAN
NC score	0.041821 (rank : 170)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	163	Target Neighborhood Hits	1062	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

KRA47_HUMAN
NC score	0.039189 (rank : 171)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	163	Target Neighborhood Hits	204	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BYR0	Gene names	KRTAP4-7, KAP4.7, KRTAP4.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7).

KR10A_HUMAN
NC score	0.035364 (rank : 172)	θ value	4.03905 (rank : 143)
Query Neighborhood Hits	163	Target Neighborhood Hits	232	Shared Neighborhood Hits	36
SwissProt Accessions	P60014	Gene names	KRTAP10-10, KAP10.10, KAP18-10, KRTAP10.10, KRTAP18-1, KRTAP18.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-10 (Keratin-associated protein 10.10) (High sulfur keratin-associated protein 10.10) (Keratin-associated protein 18-10) (Keratin-associated protein 18.10).

MMP26_HUMAN
NC score	0.035327 (rank : 173)	θ value	5.27518 (rank : 151)
Query Neighborhood Hits	163	Target Neighborhood Hits	56	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NRE1, Q9GZS2, Q9NR87	Gene names	MMP26
Domain Architecture
Description	Matrix metalloproteinase-26 precursor (EC 3.4.24.-) (MMP-26) (Matrilysin-2) (Endometase).

ZAN_HUMAN
NC score	0.032961 (rank : 174)	θ value	0.813845 (rank : 127)
Query Neighborhood Hits	163	Target Neighborhood Hits	679	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

MMP7_MOUSE
NC score	0.032718 (rank : 175)	θ value	0.47712 (rank : 124)
Query Neighborhood Hits	163	Target Neighborhood Hits	60	Shared Neighborhood Hits	21
SwissProt Accessions	Q10738	Gene names	Mmp7
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

PCSK5_HUMAN
NC score	0.024115 (rank : 176)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	163	Target Neighborhood Hits	291	Shared Neighborhood Hits	27
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

NID2_MOUSE
NC score	0.015221 (rank : 177)	θ value	8.99809 (rank : 160)
Query Neighborhood Hits	163	Target Neighborhood Hits	338	Shared Neighborhood Hits	18
SwissProt Accessions	O88322	Gene names	Nid2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Entactin-2).

MBD1_HUMAN
NC score	0.013823 (rank : 178)	θ value	0.279714 (rank : 123)
Query Neighborhood Hits	163	Target Neighborhood Hits	77	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UIS9, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9	Gene names	MBD1, PCM1
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1).

TP4AP_HUMAN
NC score	0.010469 (rank : 179)	θ value	4.03905 (rank : 147)
Query Neighborhood Hits	163	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TEL6, Q96H82, Q9BVB8, Q9H429, Q9UFS6	Gene names	TRPC4AP, C20orf188, TRRP4AP
Domain Architecture	No domain graphic available
Description	Trpc4-associated protein (Short transient receptor potential channel 4-associated protein) (Trp4-associated protein) (TAP1 protein) (TNF- receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS).

TP4AP_MOUSE
NC score	0.010447 (rank : 180)	θ value	4.03905 (rank : 148)
Query Neighborhood Hits	163	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLV2, Q920J6, Q99L03	Gene names	Trpc4ap, Trrp4ap
Domain Architecture	No domain graphic available
Description	Trpc4-associated protein (Trp4-associated protein) (Short transient receptor potential channel 4-associated protein) (TNF-receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS) (TAP1 protein) (Rabex-5/Rin2-interacting protein).

GP156_HUMAN
NC score	0.010398 (rank : 181)	θ value	1.06291 (rank : 130)
Query Neighborhood Hits	163	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NFN8, Q86SN6	Gene names	GPR156, GABABL, PGR28
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 156 (GABAB-related G-protein coupled receptor) (G-protein coupled receptor PGR28).

LYPD5_MOUSE
NC score	0.010223 (rank : 182)	θ value	8.99809 (rank : 158)
Query Neighborhood Hits	163	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D7Z7	Gene names	Lypd5
Domain Architecture	No domain graphic available
Description	Ly6/PLAUR domain-containing protein 5 precursor.

TNF13_HUMAN
NC score	0.007642 (rank : 183)	θ value	4.03905 (rank : 146)
Query Neighborhood Hits	163	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	O75888, Q96HV6, Q9P1M8, Q9P1M9	Gene names	TNFSF13, APRIL, TALL2, ZTNF2
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 13 precursor (A proliferation-inducing ligand) (APRIL) (TNF- and APOL-related leukocyte expressed ligand 2) (TALL-2) (TNF-related death ligand 1) (TRDL-1) (CD256 antigen).

HGF_HUMAN
NC score	0.007165 (rank : 184)	θ value	0.21417 (rank : 121)
Query Neighborhood Hits	163	Target Neighborhood Hits	191	Shared Neighborhood Hits	6
SwissProt Accessions	P14210, Q02935, Q13494, Q14519, Q8TCE2, Q9BYL9, Q9BYM0, Q9UDU6	Gene names	HGF, HPTA
Domain Architecture
Description	Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain].

HGF_MOUSE
NC score	0.007126 (rank : 185)	θ value	0.21417 (rank : 122)
Query Neighborhood Hits	163	Target Neighborhood Hits	192	Shared Neighborhood Hits	6
SwissProt Accessions	Q08048, Q61662, Q64007, Q6LBE6	Gene names	Hgf
Domain Architecture
Description	Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain].

TAB2_HUMAN
NC score	0.006651 (rank : 186)	θ value	1.81305 (rank : 136)
Query Neighborhood Hits	163	Target Neighborhood Hits	169	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NYJ8, O94838, Q6I9W8, Q76N06, Q9UFP7	Gene names	MAP3K7IP2, KIAA0733, TAB2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2).

COASY_HUMAN
NC score	0.004166 (rank : 187)	θ value	8.99809 (rank : 156)
Query Neighborhood Hits	163	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q13057, Q8NBM7, Q8NEW1, Q8WXD4, Q9NRM3	Gene names	COASY
Domain Architecture
Description	Bifunctional coenzyme A synthase (CoA synthase) (NBP) (POV-2) [Includes: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Pantetheine-phosphate adenylyltransferase) (PPAT) (Dephospho-CoA pyrophosphorylase); Dephospho-CoA kinase (EC 2.7.1.24) (DPCK) (Dephosphocoenzyme A kinase) (DPCOAK)].

FUBP2_HUMAN
NC score	0.003041 (rank : 188)	θ value	4.03905 (rank : 142)
Query Neighborhood Hits	163	Target Neighborhood Hits	145	Shared Neighborhood Hits	2
SwissProt Accessions	Q92945, O00301, Q9UNT5, Q9UQH5	Gene names	KHSRP, FUBP2
Domain Architecture
Description	Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75).

MDM2_HUMAN
NC score	0.002675 (rank : 189)	θ value	8.99809 (rank : 159)
Query Neighborhood Hits	163	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

LPP_MOUSE
NC score	0.000256 (rank : 190)	θ value	4.03905 (rank : 145)
Query Neighborhood Hits	163	Target Neighborhood Hits	247	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BFW7, Q5U407, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101	Gene names	Lpp
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner homolog.

UBP42_HUMAN
NC score	-0.001892 (rank : 191)	θ value	8.99809 (rank : 163)
Query Neighborhood Hits	163	Target Neighborhood Hits	445	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).