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Network neighborhood for query Sequence : RSPO1_MOUSE

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RSPO1_MOUSE
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RSPO1_MOUSE
θ value	4.57613e-145 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	85	Target Neighborhood Hits	85	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

RSPO1_HUMAN
θ value	6.41512e-131 (rank : 2)	NC score	0.988062 (rank : 2)
Query Neighborhood Hits	85	Target Neighborhood Hits	101	Shared Neighborhood Hits	66
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

RSPO3_HUMAN
θ value	3.14151e-61 (rank : 3)	NC score	0.947889 (rank : 4)
Query Neighborhood Hits	85	Target Neighborhood Hits	128	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO3_MOUSE
θ value	1.19377e-60 (rank : 4)	NC score	0.952255 (rank : 3)
Query Neighborhood Hits	85	Target Neighborhood Hits	120	Shared Neighborhood Hits	54
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO2_MOUSE
θ value	7.25919e-50 (rank : 5)	NC score	0.936432 (rank : 6)
Query Neighborhood Hits	85	Target Neighborhood Hits	88	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

RSPO2_HUMAN
θ value	2.1121e-49 (rank : 6)	NC score	0.937904 (rank : 5)
Query Neighborhood Hits	85	Target Neighborhood Hits	90	Shared Neighborhood Hits	47
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

RSPO4_HUMAN
θ value	3.26607e-42 (rank : 7)	NC score	0.912101 (rank : 7)
Query Neighborhood Hits	85	Target Neighborhood Hits	110	Shared Neighborhood Hits	50
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

RSPO4_MOUSE
θ value	2.86122e-38 (rank : 8)	NC score	0.905112 (rank : 8)
Query Neighborhood Hits	85	Target Neighborhood Hits	110	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

PCSK5_MOUSE
θ value	8.67504e-11 (rank : 9)	NC score	0.282752 (rank : 15)
Query Neighborhood Hits	85	Target Neighborhood Hits	613	Shared Neighborhood Hits	56
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

PCSK6_HUMAN
θ value	2.36244e-08 (rank : 10)	NC score	0.296244 (rank : 11)
Query Neighborhood Hits	85	Target Neighborhood Hits	298	Shared Neighborhood Hits	43
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

PCSK5_HUMAN
θ value	5.26297e-08 (rank : 11)	NC score	0.288568 (rank : 14)
Query Neighborhood Hits	85	Target Neighborhood Hits	291	Shared Neighborhood Hits	45
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

FRAS1_HUMAN
θ value	3.77169e-06 (rank : 12)	NC score	0.239304 (rank : 17)
Query Neighborhood Hits	85	Target Neighborhood Hits	759	Shared Neighborhood Hits	61
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

SPON1_MOUSE
θ value	1.43324e-05 (rank : 13)	NC score	0.289893 (rank : 12)
Query Neighborhood Hits	85	Target Neighborhood Hits	123	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

FRAS1_MOUSE
θ value	4.1701e-05 (rank : 14)	NC score	0.240333 (rank : 16)
Query Neighborhood Hits	85	Target Neighborhood Hits	747	Shared Neighborhood Hits	60
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

SPON1_HUMAN
θ value	4.1701e-05 (rank : 15)	NC score	0.288707 (rank : 13)
Query Neighborhood Hits	85	Target Neighborhood Hits	117	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

SSPO_MOUSE
θ value	0.000602161 (rank : 16)	NC score	0.165760 (rank : 20)
Query Neighborhood Hits	85	Target Neighborhood Hits	800	Shared Neighborhood Hits	74
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

SPON2_MOUSE
θ value	0.00102713 (rank : 17)	NC score	0.310695 (rank : 10)
Query Neighborhood Hits	85	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BMS2, Q6SJD8	Gene names	Spon2
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin).

SPON2_HUMAN
θ value	0.00175202 (rank : 18)	NC score	0.319790 (rank : 9)
Query Neighborhood Hits	85	Target Neighborhood Hits	53	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BUD6, Q9ULW1	Gene names	SPON2, DIL1
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1).

BAI2_MOUSE
θ value	0.00390308 (rank : 19)	NC score	0.151678 (rank : 23)
Query Neighborhood Hits	85	Target Neighborhood Hits	323	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

INSRR_HUMAN
θ value	0.00509761 (rank : 20)	NC score	0.075550 (rank : 71)
Query Neighborhood Hits	85	Target Neighborhood Hits	950	Shared Neighborhood Hits	30
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_MOUSE
θ value	0.00665767 (rank : 21)	NC score	0.070707 (rank : 85)
Query Neighborhood Hits	85	Target Neighborhood Hits	968	Shared Neighborhood Hits	27
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_HUMAN
θ value	0.00869519 (rank : 22)	NC score	0.068414 (rank : 96)
Query Neighborhood Hits	85	Target Neighborhood Hits	963	Shared Neighborhood Hits	28
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

TNR6B_HUMAN
θ value	0.0113563 (rank : 23)	NC score	0.145339 (rank : 25)
Query Neighborhood Hits	85	Target Neighborhood Hits	103	Shared Neighborhood Hits	22
SwissProt Accessions	O95407	Gene names	TNFRSF6B, DCR3, TR6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 6B precursor (Decoy receptor for Fas ligand) (Decoy receptor 3) (DcR3) (M68).

INSRR_MOUSE
θ value	0.0148317 (rank : 24)	NC score	0.073137 (rank : 76)
Query Neighborhood Hits	85	Target Neighborhood Hits	961	Shared Neighborhood Hits	33
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

BAI2_HUMAN
θ value	0.0193708 (rank : 25)	NC score	0.152045 (rank : 22)
Query Neighborhood Hits	85	Target Neighborhood Hits	332	Shared Neighborhood Hits	47
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI3_MOUSE
θ value	0.0736092 (rank : 26)	NC score	0.137281 (rank : 27)
Query Neighborhood Hits	85	Target Neighborhood Hits	250	Shared Neighborhood Hits	44
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

ATS17_HUMAN
θ value	0.0961366 (rank : 27)	NC score	0.095073 (rank : 44)
Query Neighborhood Hits	85	Target Neighborhood Hits	194	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

CILP2_HUMAN
θ value	0.125558 (rank : 28)	NC score	0.121475 (rank : 31)
Query Neighborhood Hits	85	Target Neighborhood Hits	307	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

IGF1R_HUMAN
θ value	0.125558 (rank : 29)	NC score	0.072963 (rank : 77)
Query Neighborhood Hits	85	Target Neighborhood Hits	977	Shared Neighborhood Hits	36
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

SCUB3_MOUSE
θ value	0.125558 (rank : 30)	NC score	0.069816 (rank : 89)
Query Neighborhood Hits	85	Target Neighborhood Hits	442	Shared Neighborhood Hits	36
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

PROP_MOUSE
θ value	0.163984 (rank : 31)	NC score	0.189627 (rank : 18)
Query Neighborhood Hits	85	Target Neighborhood Hits	165	Shared Neighborhood Hits	43
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

IGF1R_MOUSE
θ value	0.21417 (rank : 32)	NC score	0.073686 (rank : 75)
Query Neighborhood Hits	85	Target Neighborhood Hits	973	Shared Neighborhood Hits	33
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

LTBP2_MOUSE
θ value	0.279714 (rank : 33)	NC score	0.061864 (rank : 120)
Query Neighborhood Hits	85	Target Neighborhood Hits	617	Shared Neighborhood Hits	36
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

ATS16_MOUSE
θ value	0.365318 (rank : 34)	NC score	0.100363 (rank : 39)
Query Neighborhood Hits	85	Target Neighborhood Hits	179	Shared Neighborhood Hits	41
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

BAI1_HUMAN
θ value	0.365318 (rank : 35)	NC score	0.136812 (rank : 28)
Query Neighborhood Hits	85	Target Neighborhood Hits	375	Shared Neighborhood Hits	44
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI1_MOUSE
θ value	0.365318 (rank : 36)	NC score	0.131595 (rank : 29)
Query Neighborhood Hits	85	Target Neighborhood Hits	340	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI3_HUMAN
θ value	0.365318 (rank : 37)	NC score	0.137302 (rank : 26)
Query Neighborhood Hits	85	Target Neighborhood Hits	246	Shared Neighborhood Hits	45
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

LTBP4_MOUSE
θ value	0.365318 (rank : 38)	NC score	0.068603 (rank : 95)
Query Neighborhood Hits	85	Target Neighborhood Hits	607	Shared Neighborhood Hits	46
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

PROP_HUMAN
θ value	0.365318 (rank : 39)	NC score	0.176265 (rank : 19)
Query Neighborhood Hits	85	Target Neighborhood Hits	126	Shared Neighborhood Hits	47
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

BMPER_HUMAN
θ value	0.47712 (rank : 40)	NC score	0.103191 (rank : 37)
Query Neighborhood Hits	85	Target Neighborhood Hits	175	Shared Neighborhood Hits	20
SwissProt Accessions	Q8N8U9	Gene names	BMPER
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

CILP1_HUMAN
θ value	0.47712 (rank : 41)	NC score	0.124795 (rank : 30)
Query Neighborhood Hits	85	Target Neighborhood Hits	266	Shared Neighborhood Hits	40
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

CILP1_MOUSE
θ value	0.47712 (rank : 42)	NC score	0.105925 (rank : 34)
Query Neighborhood Hits	85	Target Neighborhood Hits	282	Shared Neighborhood Hits	34
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

HMCN1_HUMAN
θ value	0.47712 (rank : 43)	NC score	0.086561 (rank : 55)
Query Neighborhood Hits	85	Target Neighborhood Hits	983	Shared Neighborhood Hits	68
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

SCUB3_HUMAN
θ value	0.47712 (rank : 44)	NC score	0.061967 (rank : 118)
Query Neighborhood Hits	85	Target Neighborhood Hits	428	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IX30, Q5CZB3, Q86UZ9, Q8NAU9	Gene names	SCUBE3, CEGF3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

CO8B_MOUSE
θ value	0.62314 (rank : 45)	NC score	0.084615 (rank : 57)
Query Neighborhood Hits	85	Target Neighborhood Hits	224	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

SREC2_HUMAN
θ value	0.62314 (rank : 46)	NC score	0.083368 (rank : 58)
Query Neighborhood Hits	85	Target Neighborhood Hits	645	Shared Neighborhood Hits	42
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

TNR5_MOUSE
θ value	0.62314 (rank : 47)	NC score	0.097229 (rank : 41)
Query Neighborhood Hits	85	Target Neighborhood Hits	131	Shared Neighborhood Hits	23
SwissProt Accessions	P27512, Q99NE0, Q99NE1, Q99NE2, Q99NE3	Gene names	Cd40, Tnfrsf5
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 5 precursor (CD40L receptor) (B-cell surface antigen CD40) (BP50) (CDw40).

ATS16_HUMAN
θ value	0.813845 (rank : 48)	NC score	0.093107 (rank : 47)
Query Neighborhood Hits	85	Target Neighborhood Hits	208	Shared Neighborhood Hits	43
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS20_MOUSE
θ value	0.813845 (rank : 49)	NC score	0.098396 (rank : 40)
Query Neighborhood Hits	85	Target Neighborhood Hits	225	Shared Neighborhood Hits	46
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATL5_HUMAN
θ value	1.06291 (rank : 50)	NC score	0.081821 (rank : 61)
Query Neighborhood Hits	85	Target Neighborhood Hits	103	Shared Neighborhood Hits	28
SwissProt Accessions	Q6ZMM2, Q8IW95	Gene names	ADAMTSL5, THSD6
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 5 precursor (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6).

RNF31_HUMAN
θ value	1.06291 (rank : 51)	NC score	0.035231 (rank : 158)
Query Neighborhood Hits	85	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q96EP0, Q86VI2, Q8TEI0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2	Gene names	RNF31, ZIBRA
Domain Architecture
Description	RING finger protein 31 (Zinc in-between-RING-finger ubiquitin- associated domain protein).

ADA18_HUMAN
θ value	1.38821 (rank : 52)	NC score	0.020501 (rank : 164)
Query Neighborhood Hits	85	Target Neighborhood Hits	184	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y3Q7, Q6UXJ9	Gene names	ADAM18, TMDC3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III).

BMPER_MOUSE
θ value	1.38821 (rank : 53)	NC score	0.088453 (rank : 54)
Query Neighborhood Hits	85	Target Neighborhood Hits	194	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CJ69, Q7TN57, Q80UZ1, Q9CXM8	Gene names	Bmper, Cv2
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (mCV2).

CCD27_HUMAN
θ value	1.38821 (rank : 54)	NC score	0.013786 (rank : 165)
Query Neighborhood Hits	85	Target Neighborhood Hits	594	Shared Neighborhood Hits	3
SwissProt Accessions	Q2M243, Q5TBV3, Q96M50	Gene names	CCDC27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

C1QR1_HUMAN
θ value	1.81305 (rank : 55)	NC score	0.047453 (rank : 153)
Query Neighborhood Hits	85	Target Neighborhood Hits	493	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

EGFL9_HUMAN
θ value	1.81305 (rank : 56)	NC score	0.032958 (rank : 159)
Query Neighborhood Hits	85	Target Neighborhood Hits	365	Shared Neighborhood Hits	29
SwissProt Accessions	Q6UY11, Q9BQ54	Gene names	EGFL9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9).

ATS20_HUMAN
θ value	2.36792 (rank : 57)	NC score	0.091756 (rank : 53)
Query Neighborhood Hits	85	Target Neighborhood Hits	192	Shared Neighborhood Hits	47
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS8_MOUSE
θ value	2.36792 (rank : 58)	NC score	0.063621 (rank : 109)
Query Neighborhood Hits	85	Target Neighborhood Hits	139	Shared Neighborhood Hits	32
SwissProt Accessions	P57110	Gene names	Adamts8
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2).

CO8B_HUMAN
θ value	2.36792 (rank : 59)	NC score	0.079513 (rank : 63)
Query Neighborhood Hits	85	Target Neighborhood Hits	199	Shared Neighborhood Hits	35
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

EGFL9_MOUSE
θ value	2.36792 (rank : 60)	NC score	0.032366 (rank : 161)
Query Neighborhood Hits	85	Target Neighborhood Hits	379	Shared Neighborhood Hits	28
SwissProt Accessions	Q8K1E3, Q9QYP3	Gene names	Egfl9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9) (Endothelial cell-specific protein S-1).

EGFR_MOUSE
θ value	2.36792 (rank : 61)	NC score	0.031684 (rank : 162)
Query Neighborhood Hits	85	Target Neighborhood Hits	927	Shared Neighborhood Hits	27
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

LAMA1_MOUSE
θ value	2.36792 (rank : 62)	NC score	0.044995 (rank : 155)
Query Neighborhood Hits	85	Target Neighborhood Hits	838	Shared Neighborhood Hits	44
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

LAMA5_HUMAN
θ value	2.36792 (rank : 63)	NC score	0.052661 (rank : 147)
Query Neighborhood Hits	85	Target Neighborhood Hits	976	Shared Neighborhood Hits	47
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

RNF31_MOUSE
θ value	2.36792 (rank : 64)	NC score	0.032950 (rank : 160)
Query Neighborhood Hits	85	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	Q924T7	Gene names	Rnf31
Domain Architecture
Description	RING finger protein 31.

ATS6_HUMAN
θ value	3.0926 (rank : 65)	NC score	0.067052 (rank : 99)
Query Neighborhood Hits	85	Target Neighborhood Hits	141	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UKP5	Gene names	ADAMTS6
Domain Architecture
Description	ADAMTS-6 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 6) (ADAM-TS 6) (ADAM-TS6).

MEGF8_HUMAN
θ value	3.0926 (rank : 66)	NC score	0.065201 (rank : 103)
Query Neighborhood Hits	85	Target Neighborhood Hits	528	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z7M0, O75097	Gene names	MEGF8, EGFL4, KIAA0817
Domain Architecture
Description	Multiple epidermal growth factor-like domains 8 (EGF-like domain- containing protein 4) (Multiple EGF-like domain protein 4).

TNR14_HUMAN
θ value	3.0926 (rank : 67)	NC score	0.076114 (rank : 68)
Query Neighborhood Hits	85	Target Neighborhood Hits	149	Shared Neighborhood Hits	26
SwissProt Accessions	Q92956, Q8WXR1, Q96J31, Q9UM65	Gene names	TNFRSF14, HVEA, HVEM
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 14 precursor (Herpesvirus entry mediator A) (Tumor necrosis factor receptor-like 2) (TR2).

TSP2_HUMAN
θ value	3.0926 (rank : 68)	NC score	0.104787 (rank : 35)
Query Neighborhood Hits	85	Target Neighborhood Hits	359	Shared Neighborhood Hits	57
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

ATS15_HUMAN
θ value	4.03905 (rank : 69)	NC score	0.061922 (rank : 119)
Query Neighborhood Hits	85	Target Neighborhood Hits	151	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TE58	Gene names	ADAMTS15
Domain Architecture
Description	ADAMTS-15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 15) (ADAM-TS 15) (ADAM-TS15).

MK_MOUSE
θ value	4.03905 (rank : 70)	NC score	0.038270 (rank : 156)
Query Neighborhood Hits	85	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	P12025	Gene names	Mdk, Mk
Domain Architecture
Description	Midkine precursor (MK) (Retinoic acid-induced differentiation factor).

AHTF1_MOUSE
θ value	5.27518 (rank : 71)	NC score	0.012708 (rank : 166)
Query Neighborhood Hits	85	Target Neighborhood Hits	176	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CJF7, Q8BVJ5, Q8VD55	Gene names	Ahctf1, Elys
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

ATS5_MOUSE
θ value	5.27518 (rank : 72)	NC score	0.060075 (rank : 124)
Query Neighborhood Hits	85	Target Neighborhood Hits	147	Shared Neighborhood Hits	32
SwissProt Accessions	Q9R001	Gene names	Adamts5
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (Implantin).

CO6_HUMAN
θ value	5.27518 (rank : 73)	NC score	0.082000 (rank : 60)
Query Neighborhood Hits	85	Target Neighborhood Hits	331	Shared Neighborhood Hits	43
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

CO7_HUMAN
θ value	5.27518 (rank : 74)	NC score	0.062663 (rank : 114)
Query Neighborhood Hits	85	Target Neighborhood Hits	278	Shared Neighborhood Hits	41
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

KRA53_HUMAN
θ value	5.27518 (rank : 75)	NC score	0.070046 (rank : 88)
Query Neighborhood Hits	85	Target Neighborhood Hits	331	Shared Neighborhood Hits	31
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

TNR4_HUMAN
θ value	5.27518 (rank : 76)	NC score	0.038236 (rank : 157)
Query Neighborhood Hits	85	Target Neighborhood Hits	152	Shared Neighborhood Hits	19
SwissProt Accessions	P43489, Q13663, Q5T7M0	Gene names	TNFRSF4, TXGP1L
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 4 precursor (OX40L receptor) (ACT35 antigen) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD134 antigen).

FURIN_HUMAN
θ value	6.88961 (rank : 77)	NC score	0.153503 (rank : 21)
Query Neighborhood Hits	85	Target Neighborhood Hits	52	Shared Neighborhood Hits	17
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

KIF12_MOUSE
θ value	6.88961 (rank : 78)	NC score	0.005499 (rank : 167)
Query Neighborhood Hits	85	Target Neighborhood Hits	94	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D2Z8, O35061	Gene names	Kif12
Domain Architecture
Description	Kinesin-like protein KIF12.

LAMC3_HUMAN
θ value	6.88961 (rank : 79)	NC score	0.048413 (rank : 152)
Query Neighborhood Hits	85	Target Neighborhood Hits	588	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y6N6	Gene names	LAMC3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

MEGF8_MOUSE
θ value	6.88961 (rank : 80)	NC score	0.062484 (rank : 116)
Query Neighborhood Hits	85	Target Neighborhood Hits	520	Shared Neighborhood Hits	33
SwissProt Accessions	P60882, Q80TR3, Q80V41, Q8BMN9, Q8JZW7, Q8K0J3	Gene names	Megf8, Egfl4
Domain Architecture
Description	Multiple epidermal growth factor-like domains 8 (EGF-like domain- containing protein 4) (Multiple EGF-like domain protein 4).

TNR22_MOUSE
θ value	6.88961 (rank : 81)	NC score	0.056206 (rank : 138)
Query Neighborhood Hits	85	Target Neighborhood Hits	97	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ER62, Q8VHB9, Q9CZA4	Gene names	Tnfrsf22, Dctrailr2, Tnfrh2, Tnfrsf1al2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 22 (Tumor necrosis factor receptor p60 homolog 2) (TNF receptor family member SOBa) (Decoy TRAIL receptor 2) (TNF receptor homolog 2).

ATAD2_HUMAN
θ value	8.99809 (rank : 82)	NC score	0.002609 (rank : 168)
Query Neighborhood Hits	85	Target Neighborhood Hits	322	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

MEGF6_HUMAN
θ value	8.99809 (rank : 83)	NC score	0.082051 (rank : 59)
Query Neighborhood Hits	85	Target Neighborhood Hits	671	Shared Neighborhood Hits	56
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

MK_HUMAN
θ value	8.99809 (rank : 84)	NC score	0.023586 (rank : 163)
Query Neighborhood Hits	85	Target Neighborhood Hits	11	Shared Neighborhood Hits	7
SwissProt Accessions	P21741	Gene names	MDK, MK1, NEGF2
Domain Architecture
Description	Midkine precursor (MK) (Neurite outgrowth-promoting protein) (Midgestation and kidney protein) (Amphiregulin-associated protein) (ARAP) (Neurite outgrowth-promoting factor 2).

TNR7_HUMAN
θ value	8.99809 (rank : 85)	NC score	0.045979 (rank : 154)
Query Neighborhood Hits	85	Target Neighborhood Hits	120	Shared Neighborhood Hits	20
SwissProt Accessions	P26842	Gene names	TNFRSF7, CD27
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 7 precursor (CD27L receptor) (T-cell activation antigen CD27) (T14).

ATL1_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.062721 (rank : 113)
Query Neighborhood Hits	85	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q8N6G6, Q5T708, Q96RW4, Q9BXY3	Gene names	ADAMTSL1, ADAMTSR1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (ADAMTSL-1) (Punctin-1).

ATL1_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.058185 (rank : 132)
Query Neighborhood Hits	85	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BLI0	Gene names	Adamtsl1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (Punctin-1).

ATL2_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.078697 (rank : 66)
Query Neighborhood Hits	85	Target Neighborhood Hits	125	Shared Neighborhood Hits	33
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

ATL2_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.079361 (rank : 64)
Query Neighborhood Hits	85	Target Neighborhood Hits	137	Shared Neighborhood Hits	33
SwissProt Accessions	Q7TSK7, Q3U0C8	Gene names	Adamtsl2, Kiaa0605, Tcp1
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2) (TSP1-repeats-containing protein 1) (TCP-1).

ATL3_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.069439 (rank : 90)
Query Neighborhood Hits	85	Target Neighborhood Hits	414	Shared Neighborhood Hits	40
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

ATS12_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.074477 (rank : 73)
Query Neighborhood Hits	85	Target Neighborhood Hits	251	Shared Neighborhood Hits	36
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS12_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.076849 (rank : 67)
Query Neighborhood Hits	85	Target Neighborhood Hits	220	Shared Neighborhood Hits	39
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS13_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.071468 (rank : 81)
Query Neighborhood Hits	85	Target Neighborhood Hits	238	Shared Neighborhood Hits	36
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS13_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.068144 (rank : 98)
Query Neighborhood Hits	85	Target Neighborhood Hits	227	Shared Neighborhood Hits	36
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS14_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.063795 (rank : 108)
Query Neighborhood Hits	85	Target Neighborhood Hits	382	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

ATS18_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.075145 (rank : 72)
Query Neighborhood Hits	85	Target Neighborhood Hits	169	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TE60, Q6P4R5, Q6ZWJ9	Gene names	ADAMTS18, ADAMTS21
Domain Architecture
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS18_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.074268 (rank : 74)
Query Neighborhood Hits	85	Target Neighborhood Hits	163	Shared Neighborhood Hits	36
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS19_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.070091 (rank : 87)
Query Neighborhood Hits	85	Target Neighborhood Hits	203	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS19_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.072836 (rank : 78)
Query Neighborhood Hits	85	Target Neighborhood Hits	188	Shared Neighborhood Hits	33
SwissProt Accessions	P59509	Gene names	Adamts19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS1_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.064107 (rank : 106)
Query Neighborhood Hits	85	Target Neighborhood Hits	159	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UHI8, Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80	Gene names	ADAMTS1, KIAA1346, METH1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1) (METH-1).

ATS1_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.068630 (rank : 94)
Query Neighborhood Hits	85	Target Neighborhood Hits	158	Shared Neighborhood Hits	35
SwissProt Accessions	P97857, O54768	Gene names	Adamts1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1).

ATS2_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.070281 (rank : 86)
Query Neighborhood Hits	85	Target Neighborhood Hits	179	Shared Neighborhood Hits	37
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS2_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.064048 (rank : 107)
Query Neighborhood Hits	85	Target Neighborhood Hits	179	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS3_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.068281 (rank : 97)
Query Neighborhood Hits	85	Target Neighborhood Hits	179	Shared Neighborhood Hits	39
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

ATS4_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.057128 (rank : 135)
Query Neighborhood Hits	85	Target Neighborhood Hits	138	Shared Neighborhood Hits	30
SwissProt Accessions	O75173, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83	Gene names	ADAMTS4, KIAA0688
Domain Architecture
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1) (ADMP-1).

ATS4_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.057984 (rank : 134)
Query Neighborhood Hits	85	Target Neighborhood Hits	145	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BNJ2, Q8K384	Gene names	Adamts4
Domain Architecture	No domain graphic available
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1).

ATS5_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.054840 (rank : 142)
Query Neighborhood Hits	85	Target Neighborhood Hits	141	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UNA0, Q9UKP2	Gene names	ADAMTS5, ADAMTS11, ADMP2
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).

ATS7_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.061164 (rank : 121)
Query Neighborhood Hits	85	Target Neighborhood Hits	169	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

ATS8_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.060529 (rank : 122)
Query Neighborhood Hits	85	Target Neighborhood Hits	145	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UP79, Q9NZS0	Gene names	ADAMTS8, METH2
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) (METH- 8).

ATS9_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.085110 (rank : 56)
Query Neighborhood Hits	85	Target Neighborhood Hits	219	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

CI094_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.055333 (rank : 140)
Query Neighborhood Hits	85	Target Neighborhood Hits	310	Shared Neighborhood Hits	28
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

CO8A_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.052966 (rank : 145)
Query Neighborhood Hits	85	Target Neighborhood Hits	200	Shared Neighborhood Hits	32
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

CO8A_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.054370 (rank : 143)
Query Neighborhood Hits	85	Target Neighborhood Hits	182	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K182, Q8CHJ9, Q8CHK1	Gene names	C8a
Domain Architecture	No domain graphic available
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

CREL1_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.092002 (rank : 52)
Query Neighborhood Hits	85	Target Neighborhood Hits	441	Shared Neighborhood Hits	30
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CREL1_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.096256 (rank : 42)
Query Neighborhood Hits	85	Target Neighborhood Hits	524	Shared Neighborhood Hits	34
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CRIM1_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.079077 (rank : 65)
Query Neighborhood Hits	85	Target Neighborhood Hits	362	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

FBN1_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.056234 (rank : 137)
Query Neighborhood Hits	85	Target Neighborhood Hits	557	Shared Neighborhood Hits	46
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

FBN1_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.055193 (rank : 141)
Query Neighborhood Hits	85	Target Neighborhood Hits	563	Shared Neighborhood Hits	43
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

FURIN_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.148483 (rank : 24)
Query Neighborhood Hits	85	Target Neighborhood Hits	49	Shared Neighborhood Hits	18
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

KR101_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.052124 (rank : 148)
Query Neighborhood Hits	85	Target Neighborhood Hits	261	Shared Neighborhood Hits	34
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

KR104_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.058810 (rank : 130)
Query Neighborhood Hits	85	Target Neighborhood Hits	313	Shared Neighborhood Hits	28
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

KR106_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.059544 (rank : 126)
Query Neighborhood Hits	85	Target Neighborhood Hits	347	Shared Neighborhood Hits	36
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

KR107_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.056836 (rank : 136)
Query Neighborhood Hits	85	Target Neighborhood Hits	330	Shared Neighborhood Hits	29
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

KR108_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.051986 (rank : 149)
Query Neighborhood Hits	85	Target Neighborhood Hits	226	Shared Neighborhood Hits	26
SwissProt Accessions	P60410	Gene names	KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-8 (Keratin-associated protein 10.8) (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8).

KRA47_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.052879 (rank : 146)
Query Neighborhood Hits	85	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BYR0	Gene names	KRTAP4-7, KAP4.7, KRTAP4.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7).

KRA51_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.069071 (rank : 92)
Query Neighborhood Hits	85	Target Neighborhood Hits	288	Shared Neighborhood Hits	29
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA52_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.064292 (rank : 105)
Query Neighborhood Hits	85	Target Neighborhood Hits	236	Shared Neighborhood Hits	22
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

KRA54_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.062647 (rank : 115)
Query Neighborhood Hits	85	Target Neighborhood Hits	270	Shared Neighborhood Hits	22
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

KRA55_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.069386 (rank : 91)
Query Neighborhood Hits	85	Target Neighborhood Hits	257	Shared Neighborhood Hits	24
SwissProt Accessions	Q701N2	Gene names	KRTAP5-5, KAP5-11, KAP5.5, KRTAP5-11, KRTAP5.11, KRTAP5.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-5 (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5) (Keratin-associated protein 5-11) (Keratin-associated protein 5.11).

KRA58_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.058841 (rank : 129)
Query Neighborhood Hits	85	Target Neighborhood Hits	324	Shared Neighborhood Hits	28
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

KRA59_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.060346 (rank : 123)
Query Neighborhood Hits	85	Target Neighborhood Hits	310	Shared Neighborhood Hits	22
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

LCE1A_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.050574 (rank : 151)
Query Neighborhood Hits	85	Target Neighborhood Hits	47	Shared Neighborhood Hits	7
SwissProt Accessions	Q5T7P2	Gene names	LCE1A, LEP1
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1A (Late envelope protein 1).

LCE1B_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.053318 (rank : 144)
Query Neighborhood Hits	85	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

LCE1F_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.050915 (rank : 150)
Query Neighborhood Hits	85	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T754	Gene names	LCE1F, LEP6
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1F (Late envelope protein 6).

MEGF9_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.058104 (rank : 133)
Query Neighborhood Hits	85	Target Neighborhood Hits	557	Shared Neighborhood Hits	33
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MEGF9_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.062358 (rank : 117)
Query Neighborhood Hits	85	Target Neighborhood Hits	896	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

NEC1_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.094323 (rank : 45)
Query Neighborhood Hits	85	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

NEC1_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.094176 (rank : 46)
Query Neighborhood Hits	85	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

NEC2_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.092354 (rank : 51)
Query Neighborhood Hits	85	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	P16519, Q14927, Q9NQG3, Q9NUG1, Q9UJC6	Gene names	PCSK2, NEC2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

NEC2_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.092575 (rank : 48)
Query Neighborhood Hits	85	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

NELL1_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.059498 (rank : 127)
Query Neighborhood Hits	85	Target Neighborhood Hits	451	Shared Neighborhood Hits	36
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

PCSK4_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.103935 (rank : 36)
Query Neighborhood Hits	85	Target Neighborhood Hits	32	Shared Neighborhood Hits	8
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

PCSK4_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.095770 (rank : 43)
Query Neighborhood Hits	85	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	P29121, Q62094	Gene names	Pcsk4, Nec-3, Nec3
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (PC4) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (KEX2-like endoprotease 3).

PCSK7_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.092474 (rank : 49)
Query Neighborhood Hits	85	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

PCSK7_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.092427 (rank : 50)
Query Neighborhood Hits	85	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

SEM5A_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.069003 (rank : 93)
Query Neighborhood Hits	85	Target Neighborhood Hits	177	Shared Neighborhood Hits	37
SwissProt Accessions	Q13591, O60408, Q1RLL9	Gene names	SEMA5A, SEMAF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

SEM5A_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.071798 (rank : 80)
Query Neighborhood Hits	85	Target Neighborhood Hits	162	Shared Neighborhood Hits	37
SwissProt Accessions	Q62217	Gene names	Sema5a, Semaf, SemF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

SEM5B_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.070978 (rank : 84)
Query Neighborhood Hits	85	Target Neighborhood Hits	178	Shared Neighborhood Hits	40
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

SEM5B_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.072528 (rank : 79)
Query Neighborhood Hits	85	Target Neighborhood Hits	190	Shared Neighborhood Hits	40
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

SREC2_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.080903 (rank : 62)
Query Neighborhood Hits	85	Target Neighborhood Hits	605	Shared Neighborhood Hits	47
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

SREC_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.076071 (rank : 69)
Query Neighborhood Hits	85	Target Neighborhood Hits	645	Shared Neighborhood Hits	46
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

THSD1_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.066435 (rank : 102)
Query Neighborhood Hits	85	Target Neighborhood Hits	136	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

THSD1_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.066991 (rank : 100)
Query Neighborhood Hits	85	Target Neighborhood Hits	153	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

TNR9_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.056056 (rank : 139)
Query Neighborhood Hits	85	Target Neighborhood Hits	137	Shared Neighborhood Hits	21
SwissProt Accessions	P20334	Gene names	Tnfrsf9, Cd137, Cd157, Ila, Ly63
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 9 precursor (4-1BB ligand receptor) (T-cell antigen 4-1BB) (CD137 antigen).

TR11B_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.064987 (rank : 104)
Query Neighborhood Hits	85	Target Neighborhood Hits	92	Shared Neighborhood Hits	19
SwissProt Accessions	O00300, O60236, Q53FX6, Q9UHP4	Gene names	TNFRSF11B, OCIF, OPG
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11B precursor (Osteoprotegerin) (Osteoclastogenesis inhibitory factor).

TSP1_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.107406 (rank : 33)
Query Neighborhood Hits	85	Target Neighborhood Hits	389	Shared Neighborhood Hits	59
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP1_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.108517 (rank : 32)
Query Neighborhood Hits	85	Target Neighborhood Hits	396	Shared Neighborhood Hits	60
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP2_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.103042 (rank : 38)
Query Neighborhood Hits	85	Target Neighborhood Hits	352	Shared Neighborhood Hits	55
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

UNC5A_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.066722 (rank : 101)
Query Neighborhood Hits	85	Target Neighborhood Hits	203	Shared Neighborhood Hits	31
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

UNC5B_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.071360 (rank : 83)
Query Neighborhood Hits	85	Target Neighborhood Hits	225	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

UNC5B_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.071412 (rank : 82)
Query Neighborhood Hits	85	Target Neighborhood Hits	226	Shared Neighborhood Hits	33
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

UNC5C_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.063500 (rank : 111)
Query Neighborhood Hits	85	Target Neighborhood Hits	226	Shared Neighborhood Hits	32
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

UNC5C_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.063543 (rank : 110)
Query Neighborhood Hits	85	Target Neighborhood Hits	225	Shared Neighborhood Hits	32
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UNC5D_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.058859 (rank : 128)
Query Neighborhood Hits	85	Target Neighborhood Hits	267	Shared Neighborhood Hits	31
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

UNC5D_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.058592 (rank : 131)
Query Neighborhood Hits	85	Target Neighborhood Hits	268	Shared Neighborhood Hits	31
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

VWF_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.059706 (rank : 125)
Query Neighborhood Hits	85	Target Neighborhood Hits	396	Shared Neighborhood Hits	37
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

VWF_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.062737 (rank : 112)
Query Neighborhood Hits	85	Target Neighborhood Hits	381	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CIZ8, Q60863, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16	Gene names	Vwf
Domain Architecture	No domain graphic available
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

ZAN_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.075642 (rank : 70)
Query Neighborhood Hits	85	Target Neighborhood Hits	808	Shared Neighborhood Hits	45
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

Hits sorted by NC score

RSPO1_MOUSE
NC score	0.999962 (rank : 1)	θ value	4.57613e-145 (rank : 1)
Query Neighborhood Hits	85	Target Neighborhood Hits	85	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

RSPO1_HUMAN
NC score	0.988062 (rank : 2)	θ value	6.41512e-131 (rank : 2)
Query Neighborhood Hits	85	Target Neighborhood Hits	101	Shared Neighborhood Hits	66
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

RSPO3_MOUSE
NC score	0.952255 (rank : 3)	θ value	1.19377e-60 (rank : 4)
Query Neighborhood Hits	85	Target Neighborhood Hits	120	Shared Neighborhood Hits	54
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO3_HUMAN
NC score	0.947889 (rank : 4)	θ value	3.14151e-61 (rank : 3)
Query Neighborhood Hits	85	Target Neighborhood Hits	128	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO2_HUMAN
NC score	0.937904 (rank : 5)	θ value	2.1121e-49 (rank : 6)
Query Neighborhood Hits	85	Target Neighborhood Hits	90	Shared Neighborhood Hits	47
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

RSPO2_MOUSE
NC score	0.936432 (rank : 6)	θ value	7.25919e-50 (rank : 5)
Query Neighborhood Hits	85	Target Neighborhood Hits	88	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

RSPO4_HUMAN
NC score	0.912101 (rank : 7)	θ value	3.26607e-42 (rank : 7)
Query Neighborhood Hits	85	Target Neighborhood Hits	110	Shared Neighborhood Hits	50
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

RSPO4_MOUSE
NC score	0.905112 (rank : 8)	θ value	2.86122e-38 (rank : 8)
Query Neighborhood Hits	85	Target Neighborhood Hits	110	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

SPON2_HUMAN
NC score	0.319790 (rank : 9)	θ value	0.00175202 (rank : 18)
Query Neighborhood Hits	85	Target Neighborhood Hits	53	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BUD6, Q9ULW1	Gene names	SPON2, DIL1
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1).

SPON2_MOUSE
NC score	0.310695 (rank : 10)	θ value	0.00102713 (rank : 17)
Query Neighborhood Hits	85	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BMS2, Q6SJD8	Gene names	Spon2
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin).

PCSK6_HUMAN
NC score	0.296244 (rank : 11)	θ value	2.36244e-08 (rank : 10)
Query Neighborhood Hits	85	Target Neighborhood Hits	298	Shared Neighborhood Hits	43
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

SPON1_MOUSE
NC score	0.289893 (rank : 12)	θ value	1.43324e-05 (rank : 13)
Query Neighborhood Hits	85	Target Neighborhood Hits	123	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

SPON1_HUMAN
NC score	0.288707 (rank : 13)	θ value	4.1701e-05 (rank : 15)
Query Neighborhood Hits	85	Target Neighborhood Hits	117	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

PCSK5_HUMAN
NC score	0.288568 (rank : 14)	θ value	5.26297e-08 (rank : 11)
Query Neighborhood Hits	85	Target Neighborhood Hits	291	Shared Neighborhood Hits	45
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

PCSK5_MOUSE
NC score	0.282752 (rank : 15)	θ value	8.67504e-11 (rank : 9)
Query Neighborhood Hits	85	Target Neighborhood Hits	613	Shared Neighborhood Hits	56
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

FRAS1_MOUSE
NC score	0.240333 (rank : 16)	θ value	4.1701e-05 (rank : 14)
Query Neighborhood Hits	85	Target Neighborhood Hits	747	Shared Neighborhood Hits	60
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

FRAS1_HUMAN
NC score	0.239304 (rank : 17)	θ value	3.77169e-06 (rank : 12)
Query Neighborhood Hits	85	Target Neighborhood Hits	759	Shared Neighborhood Hits	61
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

PROP_MOUSE
NC score	0.189627 (rank : 18)	θ value	0.163984 (rank : 31)
Query Neighborhood Hits	85	Target Neighborhood Hits	165	Shared Neighborhood Hits	43
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

PROP_HUMAN
NC score	0.176265 (rank : 19)	θ value	0.365318 (rank : 39)
Query Neighborhood Hits	85	Target Neighborhood Hits	126	Shared Neighborhood Hits	47
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

SSPO_MOUSE
NC score	0.165760 (rank : 20)	θ value	0.000602161 (rank : 16)
Query Neighborhood Hits	85	Target Neighborhood Hits	800	Shared Neighborhood Hits	74
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

FURIN_HUMAN
NC score	0.153503 (rank : 21)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	85	Target Neighborhood Hits	52	Shared Neighborhood Hits	17
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

BAI2_HUMAN
NC score	0.152045 (rank : 22)	θ value	0.0193708 (rank : 25)
Query Neighborhood Hits	85	Target Neighborhood Hits	332	Shared Neighborhood Hits	47
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI2_MOUSE
NC score	0.151678 (rank : 23)	θ value	0.00390308 (rank : 19)
Query Neighborhood Hits	85	Target Neighborhood Hits	323	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

FURIN_MOUSE
NC score	0.148483 (rank : 24)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	85	Target Neighborhood Hits	49	Shared Neighborhood Hits	18
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

TNR6B_HUMAN
NC score	0.145339 (rank : 25)	θ value	0.0113563 (rank : 23)
Query Neighborhood Hits	85	Target Neighborhood Hits	103	Shared Neighborhood Hits	22
SwissProt Accessions	O95407	Gene names	TNFRSF6B, DCR3, TR6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 6B precursor (Decoy receptor for Fas ligand) (Decoy receptor 3) (DcR3) (M68).

BAI3_HUMAN
NC score	0.137302 (rank : 26)	θ value	0.365318 (rank : 37)
Query Neighborhood Hits	85	Target Neighborhood Hits	246	Shared Neighborhood Hits	45
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BAI3_MOUSE
NC score	0.137281 (rank : 27)	θ value	0.0736092 (rank : 26)
Query Neighborhood Hits	85	Target Neighborhood Hits	250	Shared Neighborhood Hits	44
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BAI1_HUMAN
NC score	0.136812 (rank : 28)	θ value	0.365318 (rank : 35)
Query Neighborhood Hits	85	Target Neighborhood Hits	375	Shared Neighborhood Hits	44
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI1_MOUSE
NC score	0.131595 (rank : 29)	θ value	0.365318 (rank : 36)
Query Neighborhood Hits	85	Target Neighborhood Hits	340	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

CILP1_HUMAN
NC score	0.124795 (rank : 30)	θ value	0.47712 (rank : 41)
Query Neighborhood Hits	85	Target Neighborhood Hits	266	Shared Neighborhood Hits	40
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

CILP2_HUMAN
NC score	0.121475 (rank : 31)	θ value	0.125558 (rank : 28)
Query Neighborhood Hits	85	Target Neighborhood Hits	307	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

TSP1_MOUSE
NC score	0.108517 (rank : 32)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	85	Target Neighborhood Hits	396	Shared Neighborhood Hits	60
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP1_HUMAN
NC score	0.107406 (rank : 33)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	85	Target Neighborhood Hits	389	Shared Neighborhood Hits	59
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

CILP1_MOUSE
NC score	0.105925 (rank : 34)	θ value	0.47712 (rank : 42)
Query Neighborhood Hits	85	Target Neighborhood Hits	282	Shared Neighborhood Hits	34
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

TSP2_HUMAN
NC score	0.104787 (rank : 35)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	85	Target Neighborhood Hits	359	Shared Neighborhood Hits	57
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

PCSK4_HUMAN
NC score	0.103935 (rank : 36)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	85	Target Neighborhood Hits	32	Shared Neighborhood Hits	8
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

BMPER_HUMAN
NC score	0.103191 (rank : 37)	θ value	0.47712 (rank : 40)
Query Neighborhood Hits	85	Target Neighborhood Hits	175	Shared Neighborhood Hits	20
SwissProt Accessions	Q8N8U9	Gene names	BMPER
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

TSP2_MOUSE
NC score	0.103042 (rank : 38)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	85	Target Neighborhood Hits	352	Shared Neighborhood Hits	55
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

ATS16_MOUSE
NC score	0.100363 (rank : 39)	θ value	0.365318 (rank : 34)
Query Neighborhood Hits	85	Target Neighborhood Hits	179	Shared Neighborhood Hits	41
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS20_MOUSE
NC score	0.098396 (rank : 40)	θ value	0.813845 (rank : 49)
Query Neighborhood Hits	85	Target Neighborhood Hits	225	Shared Neighborhood Hits	46
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

TNR5_MOUSE
NC score	0.097229 (rank : 41)	θ value	0.62314 (rank : 47)
Query Neighborhood Hits	85	Target Neighborhood Hits	131	Shared Neighborhood Hits	23
SwissProt Accessions	P27512, Q99NE0, Q99NE1, Q99NE2, Q99NE3	Gene names	Cd40, Tnfrsf5
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 5 precursor (CD40L receptor) (B-cell surface antigen CD40) (BP50) (CDw40).

CREL1_MOUSE
NC score	0.096256 (rank : 42)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	85	Target Neighborhood Hits	524	Shared Neighborhood Hits	34
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

PCSK4_MOUSE
NC score	0.095770 (rank : 43)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	85	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	P29121, Q62094	Gene names	Pcsk4, Nec-3, Nec3
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (PC4) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (KEX2-like endoprotease 3).

ATS17_HUMAN
NC score	0.095073 (rank : 44)	θ value	0.0961366 (rank : 27)
Query Neighborhood Hits	85	Target Neighborhood Hits	194	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

NEC1_HUMAN
NC score	0.094323 (rank : 45)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	85	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

NEC1_MOUSE
NC score	0.094176 (rank : 46)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	85	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

ATS16_HUMAN
NC score	0.093107 (rank : 47)	θ value	0.813845 (rank : 48)
Query Neighborhood Hits	85	Target Neighborhood Hits	208	Shared Neighborhood Hits	43
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

NEC2_MOUSE
NC score	0.092575 (rank : 48)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	85	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

PCSK7_HUMAN
NC score	0.092474 (rank : 49)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	85	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

PCSK7_MOUSE
NC score	0.092427 (rank : 50)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	85	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

NEC2_HUMAN
NC score	0.092354 (rank : 51)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	85	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	P16519, Q14927, Q9NQG3, Q9NUG1, Q9UJC6	Gene names	PCSK2, NEC2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

CREL1_HUMAN
NC score	0.092002 (rank : 52)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	85	Target Neighborhood Hits	441	Shared Neighborhood Hits	30
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

ATS20_HUMAN
NC score	0.091756 (rank : 53)	θ value	2.36792 (rank : 57)
Query Neighborhood Hits	85	Target Neighborhood Hits	192	Shared Neighborhood Hits	47
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

BMPER_MOUSE
NC score	0.088453 (rank : 54)	θ value	1.38821 (rank : 53)
Query Neighborhood Hits	85	Target Neighborhood Hits	194	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CJ69, Q7TN57, Q80UZ1, Q9CXM8	Gene names	Bmper, Cv2
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (mCV2).

HMCN1_HUMAN
NC score	0.086561 (rank : 55)	θ value	0.47712 (rank : 43)
Query Neighborhood Hits	85	Target Neighborhood Hits	983	Shared Neighborhood Hits	68
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

ATS9_HUMAN
NC score	0.085110 (rank : 56)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	85	Target Neighborhood Hits	219	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

CO8B_MOUSE
NC score	0.084615 (rank : 57)	θ value	0.62314 (rank : 45)
Query Neighborhood Hits	85	Target Neighborhood Hits	224	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

SREC2_HUMAN
NC score	0.083368 (rank : 58)	θ value	0.62314 (rank : 46)
Query Neighborhood Hits	85	Target Neighborhood Hits	645	Shared Neighborhood Hits	42
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

MEGF6_HUMAN
NC score	0.082051 (rank : 59)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	85	Target Neighborhood Hits	671	Shared Neighborhood Hits	56
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

CO6_HUMAN
NC score	0.082000 (rank : 60)	θ value	5.27518 (rank : 73)
Query Neighborhood Hits	85	Target Neighborhood Hits	331	Shared Neighborhood Hits	43
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

ATL5_HUMAN
NC score	0.081821 (rank : 61)	θ value	1.06291 (rank : 50)
Query Neighborhood Hits	85	Target Neighborhood Hits	103	Shared Neighborhood Hits	28
SwissProt Accessions	Q6ZMM2, Q8IW95	Gene names	ADAMTSL5, THSD6
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 5 precursor (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6).

SREC2_MOUSE
NC score	0.080903 (rank : 62)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	85	Target Neighborhood Hits	605	Shared Neighborhood Hits	47
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

CO8B_HUMAN
NC score	0.079513 (rank : 63)	θ value	2.36792 (rank : 59)
Query Neighborhood Hits	85	Target Neighborhood Hits	199	Shared Neighborhood Hits	35
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

ATL2_MOUSE
NC score	0.079361 (rank : 64)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	85	Target Neighborhood Hits	137	Shared Neighborhood Hits	33
SwissProt Accessions	Q7TSK7, Q3U0C8	Gene names	Adamtsl2, Kiaa0605, Tcp1
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2) (TSP1-repeats-containing protein 1) (TCP-1).

CRIM1_HUMAN
NC score	0.079077 (rank : 65)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	85	Target Neighborhood Hits	362	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

ATL2_HUMAN
NC score	0.078697 (rank : 66)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	85	Target Neighborhood Hits	125	Shared Neighborhood Hits	33
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

ATS12_MOUSE
NC score	0.076849 (rank : 67)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	85	Target Neighborhood Hits	220	Shared Neighborhood Hits	39
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

TNR14_HUMAN
NC score	0.076114 (rank : 68)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	85	Target Neighborhood Hits	149	Shared Neighborhood Hits	26
SwissProt Accessions	Q92956, Q8WXR1, Q96J31, Q9UM65	Gene names	TNFRSF14, HVEA, HVEM
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 14 precursor (Herpesvirus entry mediator A) (Tumor necrosis factor receptor-like 2) (TR2).

SREC_HUMAN
NC score	0.076071 (rank : 69)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	85	Target Neighborhood Hits	645	Shared Neighborhood Hits	46
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

ZAN_MOUSE
NC score	0.075642 (rank : 70)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	85	Target Neighborhood Hits	808	Shared Neighborhood Hits	45
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

INSRR_HUMAN
NC score	0.075550 (rank : 71)	θ value	0.00509761 (rank : 20)
Query Neighborhood Hits	85	Target Neighborhood Hits	950	Shared Neighborhood Hits	30
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

ATS18_HUMAN
NC score	0.075145 (rank : 72)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	85	Target Neighborhood Hits	169	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TE60, Q6P4R5, Q6ZWJ9	Gene names	ADAMTS18, ADAMTS21
Domain Architecture
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS12_HUMAN
NC score	0.074477 (rank : 73)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	85	Target Neighborhood Hits	251	Shared Neighborhood Hits	36
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS18_MOUSE
NC score	0.074268 (rank : 74)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	85	Target Neighborhood Hits	163	Shared Neighborhood Hits	36
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

IGF1R_MOUSE
NC score	0.073686 (rank : 75)	θ value	0.21417 (rank : 32)
Query Neighborhood Hits	85	Target Neighborhood Hits	973	Shared Neighborhood Hits	33
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSRR_MOUSE
NC score	0.073137 (rank : 76)	θ value	0.0148317 (rank : 24)
Query Neighborhood Hits	85	Target Neighborhood Hits	961	Shared Neighborhood Hits	33
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

IGF1R_HUMAN
NC score	0.072963 (rank : 77)	θ value	0.125558 (rank : 29)
Query Neighborhood Hits	85	Target Neighborhood Hits	977	Shared Neighborhood Hits	36
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ATS19_MOUSE
NC score	0.072836 (rank : 78)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	85	Target Neighborhood Hits	188	Shared Neighborhood Hits	33
SwissProt Accessions	P59509	Gene names	Adamts19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

SEM5B_MOUSE
NC score	0.072528 (rank : 79)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	85	Target Neighborhood Hits	190	Shared Neighborhood Hits	40
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

SEM5A_MOUSE
NC score	0.071798 (rank : 80)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	85	Target Neighborhood Hits	162	Shared Neighborhood Hits	37
SwissProt Accessions	Q62217	Gene names	Sema5a, Semaf, SemF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

ATS13_HUMAN
NC score	0.071468 (rank : 81)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	85	Target Neighborhood Hits	238	Shared Neighborhood Hits	36
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

UNC5B_MOUSE
NC score	0.071412 (rank : 82)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	85	Target Neighborhood Hits	226	Shared Neighborhood Hits	33
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

UNC5B_HUMAN
NC score	0.071360 (rank : 83)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	85	Target Neighborhood Hits	225	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

SEM5B_HUMAN
NC score	0.070978 (rank : 84)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	85	Target Neighborhood Hits	178	Shared Neighborhood Hits	40
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

INSR_MOUSE
NC score	0.070707 (rank : 85)	θ value	0.00665767 (rank : 21)
Query Neighborhood Hits	85	Target Neighborhood Hits	968	Shared Neighborhood Hits	27
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

ATS2_HUMAN
NC score	0.070281 (rank : 86)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	85	Target Neighborhood Hits	179	Shared Neighborhood Hits	37
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS19_HUMAN
NC score	0.070091 (rank : 87)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	85	Target Neighborhood Hits	203	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

KRA53_HUMAN
NC score	0.070046 (rank : 88)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	85	Target Neighborhood Hits	331	Shared Neighborhood Hits	31
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

SCUB3_MOUSE
NC score	0.069816 (rank : 89)	θ value	0.125558 (rank : 30)
Query Neighborhood Hits	85	Target Neighborhood Hits	442	Shared Neighborhood Hits	36
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

ATL3_HUMAN
NC score	0.069439 (rank : 90)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	85	Target Neighborhood Hits	414	Shared Neighborhood Hits	40
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

KRA55_HUMAN
NC score	0.069386 (rank : 91)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	85	Target Neighborhood Hits	257	Shared Neighborhood Hits	24
SwissProt Accessions	Q701N2	Gene names	KRTAP5-5, KAP5-11, KAP5.5, KRTAP5-11, KRTAP5.11, KRTAP5.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-5 (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5) (Keratin-associated protein 5-11) (Keratin-associated protein 5.11).

KRA51_HUMAN
NC score	0.069071 (rank : 92)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	85	Target Neighborhood Hits	288	Shared Neighborhood Hits	29
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

SEM5A_HUMAN
NC score	0.069003 (rank : 93)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	85	Target Neighborhood Hits	177	Shared Neighborhood Hits	37
SwissProt Accessions	Q13591, O60408, Q1RLL9	Gene names	SEMA5A, SEMAF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

ATS1_MOUSE
NC score	0.068630 (rank : 94)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	85	Target Neighborhood Hits	158	Shared Neighborhood Hits	35
SwissProt Accessions	P97857, O54768	Gene names	Adamts1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1).

LTBP4_MOUSE
NC score	0.068603 (rank : 95)	θ value	0.365318 (rank : 38)
Query Neighborhood Hits	85	Target Neighborhood Hits	607	Shared Neighborhood Hits	46
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

INSR_HUMAN
NC score	0.068414 (rank : 96)	θ value	0.00869519 (rank : 22)
Query Neighborhood Hits	85	Target Neighborhood Hits	963	Shared Neighborhood Hits	28
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

ATS3_HUMAN
NC score	0.068281 (rank : 97)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	85	Target Neighborhood Hits	179	Shared Neighborhood Hits	39
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

ATS13_MOUSE
NC score	0.068144 (rank : 98)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	85	Target Neighborhood Hits	227	Shared Neighborhood Hits	36
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS6_HUMAN
NC score	0.067052 (rank : 99)	θ value	3.0926 (rank : 65)
Query Neighborhood Hits	85	Target Neighborhood Hits	141	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UKP5	Gene names	ADAMTS6
Domain Architecture
Description	ADAMTS-6 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 6) (ADAM-TS 6) (ADAM-TS6).

THSD1_MOUSE
NC score	0.066991 (rank : 100)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	85	Target Neighborhood Hits	153	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

UNC5A_MOUSE
NC score	0.066722 (rank : 101)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	85	Target Neighborhood Hits	203	Shared Neighborhood Hits	31
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

THSD1_HUMAN
NC score	0.066435 (rank : 102)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	85	Target Neighborhood Hits	136	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

MEGF8_HUMAN
NC score	0.065201 (rank : 103)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	85	Target Neighborhood Hits	528	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z7M0, O75097	Gene names	MEGF8, EGFL4, KIAA0817
Domain Architecture
Description	Multiple epidermal growth factor-like domains 8 (EGF-like domain- containing protein 4) (Multiple EGF-like domain protein 4).

TR11B_HUMAN
NC score	0.064987 (rank : 104)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	85	Target Neighborhood Hits	92	Shared Neighborhood Hits	19
SwissProt Accessions	O00300, O60236, Q53FX6, Q9UHP4	Gene names	TNFRSF11B, OCIF, OPG
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11B precursor (Osteoprotegerin) (Osteoclastogenesis inhibitory factor).

KRA52_HUMAN
NC score	0.064292 (rank : 105)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	85	Target Neighborhood Hits	236	Shared Neighborhood Hits	22
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

ATS1_HUMAN
NC score	0.064107 (rank : 106)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	85	Target Neighborhood Hits	159	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UHI8, Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80	Gene names	ADAMTS1, KIAA1346, METH1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1) (METH-1).

ATS2_MOUSE
NC score	0.064048 (rank : 107)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	85	Target Neighborhood Hits	179	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS14_HUMAN
NC score	0.063795 (rank : 108)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	85	Target Neighborhood Hits	382	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

ATS8_MOUSE
NC score	0.063621 (rank : 109)	θ value	2.36792 (rank : 58)
Query Neighborhood Hits	85	Target Neighborhood Hits	139	Shared Neighborhood Hits	32
SwissProt Accessions	P57110	Gene names	Adamts8
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2).

UNC5C_MOUSE
NC score	0.063543 (rank : 110)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	85	Target Neighborhood Hits	225	Shared Neighborhood Hits	32
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UNC5C_HUMAN
NC score	0.063500 (rank : 111)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	85	Target Neighborhood Hits	226	Shared Neighborhood Hits	32
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

VWF_MOUSE
NC score	0.062737 (rank : 112)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	85	Target Neighborhood Hits	381	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CIZ8, Q60863, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16	Gene names	Vwf
Domain Architecture	No domain graphic available
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

ATL1_HUMAN
NC score	0.062721 (rank : 113)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	85	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q8N6G6, Q5T708, Q96RW4, Q9BXY3	Gene names	ADAMTSL1, ADAMTSR1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (ADAMTSL-1) (Punctin-1).

CO7_HUMAN
NC score	0.062663 (rank : 114)	θ value	5.27518 (rank : 74)
Query Neighborhood Hits	85	Target Neighborhood Hits	278	Shared Neighborhood Hits	41
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

KRA54_HUMAN
NC score	0.062647 (rank : 115)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	85	Target Neighborhood Hits	270	Shared Neighborhood Hits	22
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

MEGF8_MOUSE
NC score	0.062484 (rank : 116)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	85	Target Neighborhood Hits	520	Shared Neighborhood Hits	33
SwissProt Accessions	P60882, Q80TR3, Q80V41, Q8BMN9, Q8JZW7, Q8K0J3	Gene names	Megf8, Egfl4
Domain Architecture
Description	Multiple epidermal growth factor-like domains 8 (EGF-like domain- containing protein 4) (Multiple EGF-like domain protein 4).

MEGF9_MOUSE
NC score	0.062358 (rank : 117)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	85	Target Neighborhood Hits	896	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

SCUB3_HUMAN
NC score	0.061967 (rank : 118)	θ value	0.47712 (rank : 44)
Query Neighborhood Hits	85	Target Neighborhood Hits	428	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IX30, Q5CZB3, Q86UZ9, Q8NAU9	Gene names	SCUBE3, CEGF3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

ATS15_HUMAN
NC score	0.061922 (rank : 119)	θ value	4.03905 (rank : 69)
Query Neighborhood Hits	85	Target Neighborhood Hits	151	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TE58	Gene names	ADAMTS15
Domain Architecture
Description	ADAMTS-15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 15) (ADAM-TS 15) (ADAM-TS15).

LTBP2_MOUSE
NC score	0.061864 (rank : 120)	θ value	0.279714 (rank : 33)
Query Neighborhood Hits	85	Target Neighborhood Hits	617	Shared Neighborhood Hits	36
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

ATS7_HUMAN
NC score	0.061164 (rank : 121)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	85	Target Neighborhood Hits	169	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

ATS8_HUMAN
NC score	0.060529 (rank : 122)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	85	Target Neighborhood Hits	145	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UP79, Q9NZS0	Gene names	ADAMTS8, METH2
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) (METH- 8).

KRA59_HUMAN
NC score	0.060346 (rank : 123)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	85	Target Neighborhood Hits	310	Shared Neighborhood Hits	22
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

ATS5_MOUSE
NC score	0.060075 (rank : 124)	θ value	5.27518 (rank : 72)
Query Neighborhood Hits	85	Target Neighborhood Hits	147	Shared Neighborhood Hits	32
SwissProt Accessions	Q9R001	Gene names	Adamts5
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (Implantin).

VWF_HUMAN
NC score	0.059706 (rank : 125)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	85	Target Neighborhood Hits	396	Shared Neighborhood Hits	37
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

KR106_HUMAN
NC score	0.059544 (rank : 126)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	85	Target Neighborhood Hits	347	Shared Neighborhood Hits	36
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

NELL1_HUMAN
NC score	0.059498 (rank : 127)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	85	Target Neighborhood Hits	451	Shared Neighborhood Hits	36
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

UNC5D_HUMAN
NC score	0.058859 (rank : 128)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	85	Target Neighborhood Hits	267	Shared Neighborhood Hits	31
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

KRA58_HUMAN
NC score	0.058841 (rank : 129)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	85	Target Neighborhood Hits	324	Shared Neighborhood Hits	28
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

KR104_HUMAN
NC score	0.058810 (rank : 130)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	85	Target Neighborhood Hits	313	Shared Neighborhood Hits	28
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

UNC5D_MOUSE
NC score	0.058592 (rank : 131)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	85	Target Neighborhood Hits	268	Shared Neighborhood Hits	31
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

ATL1_MOUSE
NC score	0.058185 (rank : 132)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	85	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BLI0	Gene names	Adamtsl1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (Punctin-1).

MEGF9_HUMAN
NC score	0.058104 (rank : 133)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	85	Target Neighborhood Hits	557	Shared Neighborhood Hits	33
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

ATS4_MOUSE
NC score	0.057984 (rank : 134)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	85	Target Neighborhood Hits	145	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BNJ2, Q8K384	Gene names	Adamts4
Domain Architecture	No domain graphic available
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1).

ATS4_HUMAN
NC score	0.057128 (rank : 135)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	85	Target Neighborhood Hits	138	Shared Neighborhood Hits	30
SwissProt Accessions	O75173, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83	Gene names	ADAMTS4, KIAA0688
Domain Architecture
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1) (ADMP-1).

KR107_HUMAN
NC score	0.056836 (rank : 136)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	85	Target Neighborhood Hits	330	Shared Neighborhood Hits	29
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

FBN1_HUMAN
NC score	0.056234 (rank : 137)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	85	Target Neighborhood Hits	557	Shared Neighborhood Hits	46
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

TNR22_MOUSE
NC score	0.056206 (rank : 138)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	85	Target Neighborhood Hits	97	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ER62, Q8VHB9, Q9CZA4	Gene names	Tnfrsf22, Dctrailr2, Tnfrh2, Tnfrsf1al2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 22 (Tumor necrosis factor receptor p60 homolog 2) (TNF receptor family member SOBa) (Decoy TRAIL receptor 2) (TNF receptor homolog 2).

TNR9_MOUSE
NC score	0.056056 (rank : 139)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	85	Target Neighborhood Hits	137	Shared Neighborhood Hits	21
SwissProt Accessions	P20334	Gene names	Tnfrsf9, Cd137, Cd157, Ila, Ly63
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 9 precursor (4-1BB ligand receptor) (T-cell antigen 4-1BB) (CD137 antigen).

CI094_HUMAN
NC score	0.055333 (rank : 140)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	85	Target Neighborhood Hits	310	Shared Neighborhood Hits	28
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

FBN1_MOUSE
NC score	0.055193 (rank : 141)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	85	Target Neighborhood Hits	563	Shared Neighborhood Hits	43
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

ATS5_HUMAN
NC score	0.054840 (rank : 142)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	85	Target Neighborhood Hits	141	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UNA0, Q9UKP2	Gene names	ADAMTS5, ADAMTS11, ADMP2
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).

CO8A_MOUSE
NC score	0.054370 (rank : 143)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	85	Target Neighborhood Hits	182	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K182, Q8CHJ9, Q8CHK1	Gene names	C8a
Domain Architecture	No domain graphic available
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

LCE1B_HUMAN
NC score	0.053318 (rank : 144)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	85	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

CO8A_HUMAN
NC score	0.052966 (rank : 145)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	85	Target Neighborhood Hits	200	Shared Neighborhood Hits	32
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

KRA47_HUMAN
NC score	0.052879 (rank : 146)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	85	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BYR0	Gene names	KRTAP4-7, KAP4.7, KRTAP4.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7).

LAMA5_HUMAN
NC score	0.052661 (rank : 147)	θ value	2.36792 (rank : 63)
Query Neighborhood Hits	85	Target Neighborhood Hits	976	Shared Neighborhood Hits	47
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

KR101_HUMAN
NC score	0.052124 (rank : 148)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	85	Target Neighborhood Hits	261	Shared Neighborhood Hits	34
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

KR108_HUMAN
NC score	0.051986 (rank : 149)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	85	Target Neighborhood Hits	226	Shared Neighborhood Hits	26
SwissProt Accessions	P60410	Gene names	KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-8 (Keratin-associated protein 10.8) (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8).

LCE1F_HUMAN
NC score	0.050915 (rank : 150)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	85	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T754	Gene names	LCE1F, LEP6
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1F (Late envelope protein 6).

LCE1A_HUMAN
NC score	0.050574 (rank : 151)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	85	Target Neighborhood Hits	47	Shared Neighborhood Hits	7
SwissProt Accessions	Q5T7P2	Gene names	LCE1A, LEP1
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1A (Late envelope protein 1).

LAMC3_HUMAN
NC score	0.048413 (rank : 152)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	85	Target Neighborhood Hits	588	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y6N6	Gene names	LAMC3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

C1QR1_HUMAN
NC score	0.047453 (rank : 153)	θ value	1.81305 (rank : 55)
Query Neighborhood Hits	85	Target Neighborhood Hits	493	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

TNR7_HUMAN
NC score	0.045979 (rank : 154)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	85	Target Neighborhood Hits	120	Shared Neighborhood Hits	20
SwissProt Accessions	P26842	Gene names	TNFRSF7, CD27
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 7 precursor (CD27L receptor) (T-cell activation antigen CD27) (T14).

LAMA1_MOUSE
NC score	0.044995 (rank : 155)	θ value	2.36792 (rank : 62)
Query Neighborhood Hits	85	Target Neighborhood Hits	838	Shared Neighborhood Hits	44
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

MK_MOUSE
NC score	0.038270 (rank : 156)	θ value	4.03905 (rank : 70)
Query Neighborhood Hits	85	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	P12025	Gene names	Mdk, Mk
Domain Architecture
Description	Midkine precursor (MK) (Retinoic acid-induced differentiation factor).

TNR4_HUMAN
NC score	0.038236 (rank : 157)	θ value	5.27518 (rank : 76)
Query Neighborhood Hits	85	Target Neighborhood Hits	152	Shared Neighborhood Hits	19
SwissProt Accessions	P43489, Q13663, Q5T7M0	Gene names	TNFRSF4, TXGP1L
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 4 precursor (OX40L receptor) (ACT35 antigen) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD134 antigen).

RNF31_HUMAN
NC score	0.035231 (rank : 158)	θ value	1.06291 (rank : 51)
Query Neighborhood Hits	85	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q96EP0, Q86VI2, Q8TEI0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2	Gene names	RNF31, ZIBRA
Domain Architecture
Description	RING finger protein 31 (Zinc in-between-RING-finger ubiquitin- associated domain protein).

EGFL9_HUMAN
NC score	0.032958 (rank : 159)	θ value	1.81305 (rank : 56)
Query Neighborhood Hits	85	Target Neighborhood Hits	365	Shared Neighborhood Hits	29
SwissProt Accessions	Q6UY11, Q9BQ54	Gene names	EGFL9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9).

RNF31_MOUSE
NC score	0.032950 (rank : 160)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	85	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	Q924T7	Gene names	Rnf31
Domain Architecture
Description	RING finger protein 31.

EGFL9_MOUSE
NC score	0.032366 (rank : 161)	θ value	2.36792 (rank : 60)
Query Neighborhood Hits	85	Target Neighborhood Hits	379	Shared Neighborhood Hits	28
SwissProt Accessions	Q8K1E3, Q9QYP3	Gene names	Egfl9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9) (Endothelial cell-specific protein S-1).

EGFR_MOUSE
NC score	0.031684 (rank : 162)	θ value	2.36792 (rank : 61)
Query Neighborhood Hits	85	Target Neighborhood Hits	927	Shared Neighborhood Hits	27
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

MK_HUMAN
NC score	0.023586 (rank : 163)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	85	Target Neighborhood Hits	11	Shared Neighborhood Hits	7
SwissProt Accessions	P21741	Gene names	MDK, MK1, NEGF2
Domain Architecture
Description	Midkine precursor (MK) (Neurite outgrowth-promoting protein) (Midgestation and kidney protein) (Amphiregulin-associated protein) (ARAP) (Neurite outgrowth-promoting factor 2).

ADA18_HUMAN
NC score	0.020501 (rank : 164)	θ value	1.38821 (rank : 52)
Query Neighborhood Hits	85	Target Neighborhood Hits	184	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y3Q7, Q6UXJ9	Gene names	ADAM18, TMDC3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III).

CCD27_HUMAN
NC score	0.013786 (rank : 165)	θ value	1.38821 (rank : 54)
Query Neighborhood Hits	85	Target Neighborhood Hits	594	Shared Neighborhood Hits	3
SwissProt Accessions	Q2M243, Q5TBV3, Q96M50	Gene names	CCDC27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

AHTF1_MOUSE
NC score	0.012708 (rank : 166)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	85	Target Neighborhood Hits	176	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CJF7, Q8BVJ5, Q8VD55	Gene names	Ahctf1, Elys
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

KIF12_MOUSE
NC score	0.005499 (rank : 167)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	85	Target Neighborhood Hits	94	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D2Z8, O35061	Gene names	Kif12
Domain Architecture
Description	Kinesin-like protein KIF12.

ATAD2_HUMAN
NC score	0.002609 (rank : 168)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	85	Target Neighborhood Hits	322	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.