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Network neighborhood for query Sequence : PCSK7_MOUSE

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PCSK7_MOUSE
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PCSK7_HUMAN
θ value	0 (rank : 1)	NC score	0.999114 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

PCSK7_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

PCSK6_HUMAN
θ value	3.89193e-128 (rank : 3)	NC score	0.864788 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	298	Shared Neighborhood Hits	13
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

PCSK5_MOUSE
θ value	5.8157e-124 (rank : 4)	NC score	0.702832 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	613	Shared Neighborhood Hits	14
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

PCSK5_HUMAN
θ value	8.39787e-123 (rank : 5)	NC score	0.852362 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	291	Shared Neighborhood Hits	13
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

NEC1_MOUSE
θ value	2.00348e-116 (rank : 6)	NC score	0.971940 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

NEC1_HUMAN
θ value	3.41741e-116 (rank : 7)	NC score	0.970957 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

PCSK4_HUMAN
θ value	9.94316e-116 (rank : 8)	NC score	0.968075 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

FURIN_HUMAN
θ value	2.6227e-108 (rank : 9)	NC score	0.961760 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	52	Shared Neighborhood Hits	13
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

FURIN_MOUSE
θ value	5.84277e-108 (rank : 10)	NC score	0.961502 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

NEC2_HUMAN
θ value	2.45477e-106 (rank : 11)	NC score	0.968378 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	P16519, Q14927, Q9NQG3, Q9NUG1, Q9UJC6	Gene names	PCSK2, NEC2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

PCSK4_MOUSE
θ value	1.59114e-105 (rank : 12)	NC score	0.971016 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	P29121, Q62094	Gene names	Pcsk4, Nec-3, Nec3
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (PC4) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (KEX2-like endoprotease 3).

NEC2_MOUSE
θ value	2.2976e-104 (rank : 13)	NC score	0.968142 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

PCSK9_MOUSE
θ value	0.0330416 (rank : 14)	NC score	0.081645 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q80W65, Q3UEH7, Q8BXW9, Q8CFT6	Gene names	Pcsk9, Narc1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

OSBL9_HUMAN
θ value	1.38821 (rank : 15)	NC score	0.017747 (rank : 30)
Query Neighborhood Hits	24	Target Neighborhood Hits	138	Shared Neighborhood Hits	3
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

CELR1_MOUSE
θ value	1.81305 (rank : 16)	NC score	0.002903 (rank : 39)
Query Neighborhood Hits	24	Target Neighborhood Hits	617	Shared Neighborhood Hits	3
SwissProt Accessions	O35161	Gene names	Celsr1
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor.

COVA1_HUMAN
θ value	2.36792 (rank : 17)	NC score	0.016231 (rank : 32)
Query Neighborhood Hits	24	Target Neighborhood Hits	416	Shared Neighborhood Hits	3
SwissProt Accessions	Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82	Gene names	COVA1
Domain Architecture
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

COVA1_MOUSE
θ value	2.36792 (rank : 18)	NC score	0.017576 (rank : 31)
Query Neighborhood Hits	24	Target Neighborhood Hits	335	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R0Z2, Q8BY59, Q8R372	Gene names	Cova1
Domain Architecture	No domain graphic available
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

PTN12_MOUSE
θ value	2.36792 (rank : 19)	NC score	0.004821 (rank : 38)
Query Neighborhood Hits	24	Target Neighborhood Hits	123	Shared Neighborhood Hits	2
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

CAC1H_HUMAN
θ value	3.0926 (rank : 20)	NC score	0.005101 (rank : 37)
Query Neighborhood Hits	24	Target Neighborhood Hits	307	Shared Neighborhood Hits	2
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

E2F3_HUMAN
θ value	4.03905 (rank : 21)	NC score	0.010799 (rank : 33)
Query Neighborhood Hits	24	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	O00716, Q15000, Q9BZ44	Gene names	E2F3, KIAA0075
Domain Architecture
Description	Transcription factor E2F3 (E2F-3).

I10R2_HUMAN
θ value	5.27518 (rank : 22)	NC score	0.009967 (rank : 34)
Query Neighborhood Hits	24	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q08334, Q9BUU4	Gene names	IL10RB, CRFB4
Domain Architecture
Description	Interleukin-10 receptor beta chain precursor (IL-10R-B) (IL-10R2) (Cytokine receptor family 2 member 4) (Cytokine receptor class-II member 4) (CRF2-4) (CDw210b antigen).

E2F3_MOUSE
θ value	6.88961 (rank : 23)	NC score	0.009552 (rank : 35)
Query Neighborhood Hits	24	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	O35261, Q5T0I6	Gene names	E2f3
Domain Architecture	No domain graphic available
Description	Transcription factor E2F3 (E2F-3).

MYCD_MOUSE
θ value	8.99809 (rank : 24)	NC score	0.005278 (rank : 36)
Query Neighborhood Hits	24	Target Neighborhood Hits	144	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VIM5, Q8C3W6, Q8VIL4	Gene names	Myocd, Bsac2, Mycd, Srfcp
Domain Architecture
Description	Myocardin (SRF cofactor protein) (Basic SAP coiled-coil transcription activator 2).

CREL1_HUMAN
θ value	θ > 10 (rank : 25)	NC score	0.063129 (rank : 29)
Query Neighborhood Hits	24	Target Neighborhood Hits	441	Shared Neighborhood Hits	7
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CREL1_MOUSE
θ value	θ > 10 (rank : 26)	NC score	0.063912 (rank : 28)
Query Neighborhood Hits	24	Target Neighborhood Hits	524	Shared Neighborhood Hits	7
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

FRAS1_HUMAN
θ value	θ > 10 (rank : 27)	NC score	0.111056 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	759	Shared Neighborhood Hits	7
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

FRAS1_MOUSE
θ value	θ > 10 (rank : 28)	NC score	0.112338 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	747	Shared Neighborhood Hits	7
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

MBTP1_HUMAN
θ value	θ > 10 (rank : 29)	NC score	0.070123 (rank : 25)
Query Neighborhood Hits	24	Target Neighborhood Hits	28	Shared Neighborhood Hits	9
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).

MBTP1_MOUSE
θ value	θ > 10 (rank : 30)	NC score	0.064614 (rank : 27)
Query Neighborhood Hits	24	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

PCSK9_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.067631 (rank : 26)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NBP7, Q5PSM5	Gene names	PCSK9, NARC1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

RSPO1_HUMAN
θ value	θ > 10 (rank : 32)	NC score	0.103246 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	101	Shared Neighborhood Hits	5
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

RSPO1_MOUSE
θ value	θ > 10 (rank : 33)	NC score	0.092427 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

RSPO2_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.100312 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	90	Shared Neighborhood Hits	5
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

RSPO2_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.102959 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

RSPO3_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.108064 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	128	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO3_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.106899 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	120	Shared Neighborhood Hits	5
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO4_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.102971 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

RSPO4_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.107645 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

Hits sorted by NC score

PCSK7_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

PCSK7_HUMAN
NC score	0.999114 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

NEC1_MOUSE
NC score	0.971940 (rank : 3)	θ value	2.00348e-116 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

PCSK4_MOUSE
NC score	0.971016 (rank : 4)	θ value	1.59114e-105 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	P29121, Q62094	Gene names	Pcsk4, Nec-3, Nec3
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (PC4) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (KEX2-like endoprotease 3).

NEC1_HUMAN
NC score	0.970957 (rank : 5)	θ value	3.41741e-116 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

NEC2_HUMAN
NC score	0.968378 (rank : 6)	θ value	2.45477e-106 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	P16519, Q14927, Q9NQG3, Q9NUG1, Q9UJC6	Gene names	PCSK2, NEC2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

NEC2_MOUSE
NC score	0.968142 (rank : 7)	θ value	2.2976e-104 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

PCSK4_HUMAN
NC score	0.968075 (rank : 8)	θ value	9.94316e-116 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

FURIN_HUMAN
NC score	0.961760 (rank : 9)	θ value	2.6227e-108 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	52	Shared Neighborhood Hits	13
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

FURIN_MOUSE
NC score	0.961502 (rank : 10)	θ value	5.84277e-108 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

PCSK6_HUMAN
NC score	0.864788 (rank : 11)	θ value	3.89193e-128 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	298	Shared Neighborhood Hits	13
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

PCSK5_HUMAN
NC score	0.852362 (rank : 12)	θ value	8.39787e-123 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	291	Shared Neighborhood Hits	13
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

PCSK5_MOUSE
NC score	0.702832 (rank : 13)	θ value	5.8157e-124 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	613	Shared Neighborhood Hits	14
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

FRAS1_MOUSE
NC score	0.112338 (rank : 14)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	24	Target Neighborhood Hits	747	Shared Neighborhood Hits	7
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

FRAS1_HUMAN
NC score	0.111056 (rank : 15)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	24	Target Neighborhood Hits	759	Shared Neighborhood Hits	7
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

RSPO3_HUMAN
NC score	0.108064 (rank : 16)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	24	Target Neighborhood Hits	128	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO4_MOUSE
NC score	0.107645 (rank : 17)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	24	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

RSPO3_MOUSE
NC score	0.106899 (rank : 18)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	24	Target Neighborhood Hits	120	Shared Neighborhood Hits	5
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO1_HUMAN
NC score	0.103246 (rank : 19)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	24	Target Neighborhood Hits	101	Shared Neighborhood Hits	5
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

RSPO4_HUMAN
NC score	0.102971 (rank : 20)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	24	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

RSPO2_MOUSE
NC score	0.102959 (rank : 21)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	24	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

RSPO2_HUMAN
NC score	0.100312 (rank : 22)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	24	Target Neighborhood Hits	90	Shared Neighborhood Hits	5
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

RSPO1_MOUSE
NC score	0.092427 (rank : 23)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	24	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

PCSK9_MOUSE
NC score	0.081645 (rank : 24)	θ value	0.0330416 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q80W65, Q3UEH7, Q8BXW9, Q8CFT6	Gene names	Pcsk9, Narc1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

MBTP1_HUMAN
NC score	0.070123 (rank : 25)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	24	Target Neighborhood Hits	28	Shared Neighborhood Hits	9
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).

PCSK9_HUMAN
NC score	0.067631 (rank : 26)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NBP7, Q5PSM5	Gene names	PCSK9, NARC1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

MBTP1_MOUSE
NC score	0.064614 (rank : 27)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	24	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

CREL1_MOUSE
NC score	0.063912 (rank : 28)	θ value	θ > 10 (rank : 26)
Query Neighborhood Hits	24	Target Neighborhood Hits	524	Shared Neighborhood Hits	7
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CREL1_HUMAN
NC score	0.063129 (rank : 29)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	24	Target Neighborhood Hits	441	Shared Neighborhood Hits	7
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

OSBL9_HUMAN
NC score	0.017747 (rank : 30)	θ value	1.38821 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	138	Shared Neighborhood Hits	3
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

COVA1_MOUSE
NC score	0.017576 (rank : 31)	θ value	2.36792 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	335	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R0Z2, Q8BY59, Q8R372	Gene names	Cova1
Domain Architecture	No domain graphic available
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

COVA1_HUMAN
NC score	0.016231 (rank : 32)	θ value	2.36792 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	416	Shared Neighborhood Hits	3
SwissProt Accessions	Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82	Gene names	COVA1
Domain Architecture
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

E2F3_HUMAN
NC score	0.010799 (rank : 33)	θ value	4.03905 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	O00716, Q15000, Q9BZ44	Gene names	E2F3, KIAA0075
Domain Architecture
Description	Transcription factor E2F3 (E2F-3).

I10R2_HUMAN
NC score	0.009967 (rank : 34)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q08334, Q9BUU4	Gene names	IL10RB, CRFB4
Domain Architecture
Description	Interleukin-10 receptor beta chain precursor (IL-10R-B) (IL-10R2) (Cytokine receptor family 2 member 4) (Cytokine receptor class-II member 4) (CRF2-4) (CDw210b antigen).

E2F3_MOUSE
NC score	0.009552 (rank : 35)	θ value	6.88961 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	O35261, Q5T0I6	Gene names	E2f3
Domain Architecture	No domain graphic available
Description	Transcription factor E2F3 (E2F-3).

MYCD_MOUSE
NC score	0.005278 (rank : 36)	θ value	8.99809 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	144	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VIM5, Q8C3W6, Q8VIL4	Gene names	Myocd, Bsac2, Mycd, Srfcp
Domain Architecture
Description	Myocardin (SRF cofactor protein) (Basic SAP coiled-coil transcription activator 2).

CAC1H_HUMAN
NC score	0.005101 (rank : 37)	θ value	3.0926 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	307	Shared Neighborhood Hits	2
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

PTN12_MOUSE
NC score	0.004821 (rank : 38)	θ value	2.36792 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	123	Shared Neighborhood Hits	2
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

CELR1_MOUSE
NC score	0.002903 (rank : 39)	θ value	1.81305 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	617	Shared Neighborhood Hits	3
SwissProt Accessions	O35161	Gene names	Celsr1
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor.