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Network neighborhood for query Sequence : MBTP1_HUMAN

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MBTP1_HUMAN
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MBTP1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	28
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).

MBTP1_MOUSE
θ value	0 (rank : 2)	NC score	0.998156 (rank : 2)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	19
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

TPP2_HUMAN
θ value	6.64225e-11 (rank : 3)	NC score	0.375467 (rank : 3)
Query Neighborhood Hits	28	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	P29144	Gene names	TPP2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

TPP2_MOUSE
θ value	2.52405e-10 (rank : 4)	NC score	0.370516 (rank : 4)
Query Neighborhood Hits	28	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q64514	Gene names	Tpp2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

NEC1_HUMAN
θ value	0.0252991 (rank : 5)	NC score	0.108046 (rank : 7)
Query Neighborhood Hits	28	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

NEC2_MOUSE
θ value	0.0736092 (rank : 6)	NC score	0.111968 (rank : 5)
Query Neighborhood Hits	28	Target Neighborhood Hits	23	Shared Neighborhood Hits	11
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

PCSK6_HUMAN
θ value	0.0736092 (rank : 7)	NC score	0.095483 (rank : 9)
Query Neighborhood Hits	28	Target Neighborhood Hits	298	Shared Neighborhood Hits	11
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

NEC2_HUMAN
θ value	0.0961366 (rank : 8)	NC score	0.110476 (rank : 6)
Query Neighborhood Hits	28	Target Neighborhood Hits	23	Shared Neighborhood Hits	11
SwissProt Accessions	P16519, Q14927, Q9NQG3, Q9NUG1, Q9UJC6	Gene names	PCSK2, NEC2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

MUTYH_MOUSE
θ value	0.279714 (rank : 9)	NC score	0.097210 (rank : 8)
Query Neighborhood Hits	28	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	Q99P21	Gene names	Mutyh, Myh
Domain Architecture
Description	A/G-specific adenine DNA glycosylase (EC 3.2.2.-) (MutY homolog) (mMYH).

TTC13_HUMAN
θ value	0.47712 (rank : 10)	NC score	0.063975 (rank : 20)
Query Neighborhood Hits	28	Target Neighborhood Hits	117	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NBP0, Q8IVP8, Q8NBI0, Q8ND20	Gene names	TTC13
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 13 (TPR repeat protein 13).

PCSK5_HUMAN
θ value	0.813845 (rank : 11)	NC score	0.085314 (rank : 12)
Query Neighborhood Hits	28	Target Neighborhood Hits	291	Shared Neighborhood Hits	11
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

PCSK5_MOUSE
θ value	0.813845 (rank : 12)	NC score	0.070379 (rank : 17)
Query Neighborhood Hits	28	Target Neighborhood Hits	613	Shared Neighborhood Hits	13
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

ENPP5_HUMAN
θ value	1.38821 (rank : 13)	NC score	0.031531 (rank : 21)
Query Neighborhood Hits	28	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UJA9, Q6UX49	Gene names	ENPP5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

FURIN_HUMAN
θ value	1.81305 (rank : 14)	NC score	0.090580 (rank : 10)
Query Neighborhood Hits	28	Target Neighborhood Hits	52	Shared Neighborhood Hits	11
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

MUTYH_HUMAN
θ value	1.81305 (rank : 15)	NC score	0.073952 (rank : 15)
Query Neighborhood Hits	28	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UIF7, Q15830, Q9UBP2, Q9UBS7, Q9UIF4, Q9UIF5, Q9UIF6	Gene names	MUTYH, MYH
Domain Architecture
Description	A/G-specific adenine DNA glycosylase (EC 3.2.2.-) (MutY homolog) (hMYH).

CSF1_HUMAN
θ value	4.03905 (rank : 16)	NC score	0.021328 (rank : 23)
Query Neighborhood Hits	28	Target Neighborhood Hits	258	Shared Neighborhood Hits	7
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

GGN_MOUSE
θ value	4.03905 (rank : 17)	NC score	0.021800 (rank : 22)
Query Neighborhood Hits	28	Target Neighborhood Hits	311	Shared Neighborhood Hits	5
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

MLL3_HUMAN
θ value	4.03905 (rank : 18)	NC score	0.014234 (rank : 26)
Query Neighborhood Hits	28	Target Neighborhood Hits	1644	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

PCSK4_MOUSE
θ value	4.03905 (rank : 19)	NC score	0.088882 (rank : 11)
Query Neighborhood Hits	28	Target Neighborhood Hits	20	Shared Neighborhood Hits	11
SwissProt Accessions	P29121, Q62094	Gene names	Pcsk4, Nec-3, Nec3
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (PC4) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (KEX2-like endoprotease 3).

SYN3_MOUSE
θ value	5.27518 (rank : 20)	NC score	0.020251 (rank : 24)
Query Neighborhood Hits	28	Target Neighborhood Hits	200	Shared Neighborhood Hits	5
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

ZCHC8_MOUSE
θ value	5.27518 (rank : 21)	NC score	0.019315 (rank : 25)
Query Neighborhood Hits	28	Target Neighborhood Hits	134	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CYA6, Q3TK71, Q8CCB7, Q91WQ1	Gene names	Zcchc8
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 8.

MLL3_MOUSE
θ value	6.88961 (rank : 22)	NC score	0.013611 (rank : 27)
Query Neighborhood Hits	28	Target Neighborhood Hits	1399	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

CAD20_HUMAN
θ value	8.99809 (rank : 23)	NC score	0.002188 (rank : 32)
Query Neighborhood Hits	28	Target Neighborhood Hits	150	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBT6	Gene names	CDH20, CDH7L3
Domain Architecture
Description	Cadherin-20 precursor.

DGKK_HUMAN
θ value	8.99809 (rank : 24)	NC score	0.008803 (rank : 30)
Query Neighborhood Hits	28	Target Neighborhood Hits	378	Shared Neighborhood Hits	6
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

FURIN_MOUSE
θ value	8.99809 (rank : 25)	NC score	0.081478 (rank : 13)
Query Neighborhood Hits	28	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

PCLO_HUMAN
θ value	8.99809 (rank : 26)	NC score	0.010365 (rank : 28)
Query Neighborhood Hits	28	Target Neighborhood Hits	2046	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

TAIP2_MOUSE
θ value	8.99809 (rank : 27)	NC score	0.010118 (rank : 29)
Query Neighborhood Hits	28	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	P59055	Gene names	Taip2
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 2 (TAIP-2).

TTF2_MOUSE
θ value	8.99809 (rank : 28)	NC score	0.007996 (rank : 31)
Query Neighborhood Hits	28	Target Neighborhood Hits	364	Shared Neighborhood Hits	5
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

NEC1_MOUSE
θ value	θ > 10 (rank : 29)	NC score	0.080427 (rank : 14)
Query Neighborhood Hits	28	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

PCSK4_HUMAN
θ value	θ > 10 (rank : 30)	NC score	0.073568 (rank : 16)
Query Neighborhood Hits	28	Target Neighborhood Hits	32	Shared Neighborhood Hits	9
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

PCSK7_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.070079 (rank : 19)
Query Neighborhood Hits	28	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

PCSK7_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.070123 (rank : 18)
Query Neighborhood Hits	28	Target Neighborhood Hits	24	Shared Neighborhood Hits	9
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

Hits sorted by NC score

MBTP1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	28
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).

MBTP1_MOUSE
NC score	0.998156 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	19
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

TPP2_HUMAN
NC score	0.375467 (rank : 3)	θ value	6.64225e-11 (rank : 3)
Query Neighborhood Hits	28	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	P29144	Gene names	TPP2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

TPP2_MOUSE
NC score	0.370516 (rank : 4)	θ value	2.52405e-10 (rank : 4)
Query Neighborhood Hits	28	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q64514	Gene names	Tpp2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

NEC2_MOUSE
NC score	0.111968 (rank : 5)	θ value	0.0736092 (rank : 6)
Query Neighborhood Hits	28	Target Neighborhood Hits	23	Shared Neighborhood Hits	11
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

NEC2_HUMAN
NC score	0.110476 (rank : 6)	θ value	0.0961366 (rank : 8)
Query Neighborhood Hits	28	Target Neighborhood Hits	23	Shared Neighborhood Hits	11
SwissProt Accessions	P16519, Q14927, Q9NQG3, Q9NUG1, Q9UJC6	Gene names	PCSK2, NEC2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

NEC1_HUMAN
NC score	0.108046 (rank : 7)	θ value	0.0252991 (rank : 5)
Query Neighborhood Hits	28	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

MUTYH_MOUSE
NC score	0.097210 (rank : 8)	θ value	0.279714 (rank : 9)
Query Neighborhood Hits	28	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	Q99P21	Gene names	Mutyh, Myh
Domain Architecture
Description	A/G-specific adenine DNA glycosylase (EC 3.2.2.-) (MutY homolog) (mMYH).

PCSK6_HUMAN
NC score	0.095483 (rank : 9)	θ value	0.0736092 (rank : 7)
Query Neighborhood Hits	28	Target Neighborhood Hits	298	Shared Neighborhood Hits	11
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

FURIN_HUMAN
NC score	0.090580 (rank : 10)	θ value	1.81305 (rank : 14)
Query Neighborhood Hits	28	Target Neighborhood Hits	52	Shared Neighborhood Hits	11
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

PCSK4_MOUSE
NC score	0.088882 (rank : 11)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	28	Target Neighborhood Hits	20	Shared Neighborhood Hits	11
SwissProt Accessions	P29121, Q62094	Gene names	Pcsk4, Nec-3, Nec3
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (PC4) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (KEX2-like endoprotease 3).

PCSK5_HUMAN
NC score	0.085314 (rank : 12)	θ value	0.813845 (rank : 11)
Query Neighborhood Hits	28	Target Neighborhood Hits	291	Shared Neighborhood Hits	11
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

FURIN_MOUSE
NC score	0.081478 (rank : 13)	θ value	8.99809 (rank : 25)
Query Neighborhood Hits	28	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

NEC1_MOUSE
NC score	0.080427 (rank : 14)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	28	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

MUTYH_HUMAN
NC score	0.073952 (rank : 15)	θ value	1.81305 (rank : 15)
Query Neighborhood Hits	28	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UIF7, Q15830, Q9UBP2, Q9UBS7, Q9UIF4, Q9UIF5, Q9UIF6	Gene names	MUTYH, MYH
Domain Architecture
Description	A/G-specific adenine DNA glycosylase (EC 3.2.2.-) (MutY homolog) (hMYH).

PCSK4_HUMAN
NC score	0.073568 (rank : 16)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	28	Target Neighborhood Hits	32	Shared Neighborhood Hits	9
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

PCSK5_MOUSE
NC score	0.070379 (rank : 17)	θ value	0.813845 (rank : 12)
Query Neighborhood Hits	28	Target Neighborhood Hits	613	Shared Neighborhood Hits	13
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

PCSK7_MOUSE
NC score	0.070123 (rank : 18)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	28	Target Neighborhood Hits	24	Shared Neighborhood Hits	9
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

PCSK7_HUMAN
NC score	0.070079 (rank : 19)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	28	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

TTC13_HUMAN
NC score	0.063975 (rank : 20)	θ value	0.47712 (rank : 10)
Query Neighborhood Hits	28	Target Neighborhood Hits	117	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NBP0, Q8IVP8, Q8NBI0, Q8ND20	Gene names	TTC13
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 13 (TPR repeat protein 13).

ENPP5_HUMAN
NC score	0.031531 (rank : 21)	θ value	1.38821 (rank : 13)
Query Neighborhood Hits	28	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UJA9, Q6UX49	Gene names	ENPP5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

GGN_MOUSE
NC score	0.021800 (rank : 22)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	28	Target Neighborhood Hits	311	Shared Neighborhood Hits	5
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

CSF1_HUMAN
NC score	0.021328 (rank : 23)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	28	Target Neighborhood Hits	258	Shared Neighborhood Hits	7
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

SYN3_MOUSE
NC score	0.020251 (rank : 24)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	28	Target Neighborhood Hits	200	Shared Neighborhood Hits	5
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

ZCHC8_MOUSE
NC score	0.019315 (rank : 25)	θ value	5.27518 (rank : 21)
Query Neighborhood Hits	28	Target Neighborhood Hits	134	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CYA6, Q3TK71, Q8CCB7, Q91WQ1	Gene names	Zcchc8
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 8.

MLL3_HUMAN
NC score	0.014234 (rank : 26)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	28	Target Neighborhood Hits	1644	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MLL3_MOUSE
NC score	0.013611 (rank : 27)	θ value	6.88961 (rank : 22)
Query Neighborhood Hits	28	Target Neighborhood Hits	1399	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

PCLO_HUMAN
NC score	0.010365 (rank : 28)	θ value	8.99809 (rank : 26)
Query Neighborhood Hits	28	Target Neighborhood Hits	2046	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

TAIP2_MOUSE
NC score	0.010118 (rank : 29)	θ value	8.99809 (rank : 27)
Query Neighborhood Hits	28	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	P59055	Gene names	Taip2
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 2 (TAIP-2).

DGKK_HUMAN
NC score	0.008803 (rank : 30)	θ value	8.99809 (rank : 24)
Query Neighborhood Hits	28	Target Neighborhood Hits	378	Shared Neighborhood Hits	6
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

TTF2_MOUSE
NC score	0.007996 (rank : 31)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	28	Target Neighborhood Hits	364	Shared Neighborhood Hits	5
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

CAD20_HUMAN
NC score	0.002188 (rank : 32)	θ value	8.99809 (rank : 23)
Query Neighborhood Hits	28	Target Neighborhood Hits	150	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBT6	Gene names	CDH20, CDH7L3
Domain Architecture
Description	Cadherin-20 precursor.