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Network neighborhood for query Sequence : MUTYH_HUMAN

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MUTYH_HUMAN
SwissProt Accessions	Q9UIF7, Q15830, Q9UBP2, Q9UBS7, Q9UIF4, Q9UIF5, Q9UIF6	Gene names	MUTYH, MYH
Domain Architecture
Description	A/G-specific adenine DNA glycosylase (EC 3.2.2.-) (MutY homolog) (hMYH).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MUTYH_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UIF7, Q15830, Q9UBP2, Q9UBS7, Q9UIF4, Q9UIF5, Q9UIF6	Gene names	MUTYH, MYH
Domain Architecture
Description	A/G-specific adenine DNA glycosylase (EC 3.2.2.-) (MutY homolog) (hMYH).

MUTYH_MOUSE
θ value	0 (rank : 2)	NC score	0.989380 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	7
SwissProt Accessions	Q99P21	Gene names	Mutyh, Myh
Domain Architecture
Description	A/G-specific adenine DNA glycosylase (EC 3.2.2.-) (MutY homolog) (mMYH).

NTHL1_HUMAN
θ value	4.1701e-05 (rank : 3)	NC score	0.304968 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P78549, Q99566, Q99794, Q9BPX2	Gene names	NTHL1, NTH1, OCTS3
Domain Architecture
Description	Endonuclease III-like protein 1 (EC 4.2.99.18).

NTHL1_MOUSE
θ value	0.000602161 (rank : 4)	NC score	0.283777 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	O35980	Gene names	Nthl1, Nth1
Domain Architecture
Description	Endonuclease III-like protein 1 (EC 4.2.99.18).

CP2B9_MOUSE
θ value	0.813845 (rank : 5)	NC score	0.015938 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	P12790	Gene names	Cyp2b9, Cyp2b-9, Rip
Domain Architecture
Description	Cytochrome P450 2B9 (EC 1.14.14.1) (CYPIIB9) (Testosterone 16-alpha hydroxylase) (P450-16-alpha) (Clone PF26).

CP2BA_MOUSE
θ value	1.81305 (rank : 6)	NC score	0.014665 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	P12791	Gene names	Cyp2b10, Cyp2b-10
Domain Architecture
Description	Cytochrome P450 2B10 (EC 1.14.14.1) (CYPIIB10) (Testosterone 16-alpha hydroxylase) (P450-16-alpha) (Clone PF3/46).

MBTP1_HUMAN
θ value	1.81305 (rank : 7)	NC score	0.073952 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).

MBTP1_MOUSE
θ value	1.81305 (rank : 8)	NC score	0.073965 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

APOA4_HUMAN
θ value	2.36792 (rank : 9)	NC score	0.027765 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	399	Shared Neighborhood Hits	3
SwissProt Accessions	P06727, Q6Q787	Gene names	APOA4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

RIN1_MOUSE
θ value	2.36792 (rank : 10)	NC score	0.026463 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q921Q7	Gene names	Rin1
Domain Architecture
Description	Ras and Rab interactor 1 (Ras interaction/interference protein 1).

CCD22_MOUSE
θ value	4.03905 (rank : 11)	NC score	0.020410 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	268	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JIG7, Q8BYH4	Gene names	Ccdc22, DXImx40e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

EPAS1_HUMAN
θ value	4.03905 (rank : 12)	NC score	0.015617 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

GP162_HUMAN
θ value	4.03905 (rank : 13)	NC score	0.026076 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	244	Shared Neighborhood Hits	3
SwissProt Accessions	Q16538, Q16664, Q59EH5, Q66K56	Gene names	GPR162, GRCA
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 162 (Gene-rich cluster gene A protein).

GP162_MOUSE
θ value	4.03905 (rank : 14)	NC score	0.026045 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	242	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UN16, O88835	Gene names	Gpr162
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 162.

NCOA2_MOUSE
θ value	4.03905 (rank : 15)	NC score	0.022215 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	281	Shared Neighborhood Hits	4
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

SMOO_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.014119 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	391	Shared Neighborhood Hits	3
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

HLXB9_HUMAN
θ value	6.88961 (rank : 17)	NC score	0.004706 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	336	Shared Neighborhood Hits	2
SwissProt Accessions	P50219, Q9Y648	Gene names	HLXB9
Domain Architecture
Description	Homeobox protein HB9.

NCOA2_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.020304 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	281	Shared Neighborhood Hits	4
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

CC001_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.018517 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NPL8, Q6IAJ7, Q6UWU6, Q9NPR3, Q9NPS5, Q9P0Y6	Gene names	C3orf1
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf1 (Protein M5-14).

DOK2_MOUSE
θ value	8.99809 (rank : 20)	NC score	0.011244 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	244	Shared Neighborhood Hits	3
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

Hits sorted by NC score

MUTYH_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UIF7, Q15830, Q9UBP2, Q9UBS7, Q9UIF4, Q9UIF5, Q9UIF6	Gene names	MUTYH, MYH
Domain Architecture
Description	A/G-specific adenine DNA glycosylase (EC 3.2.2.-) (MutY homolog) (hMYH).

MUTYH_MOUSE
NC score	0.989380 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	7
SwissProt Accessions	Q99P21	Gene names	Mutyh, Myh
Domain Architecture
Description	A/G-specific adenine DNA glycosylase (EC 3.2.2.-) (MutY homolog) (mMYH).

NTHL1_HUMAN
NC score	0.304968 (rank : 3)	θ value	4.1701e-05 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P78549, Q99566, Q99794, Q9BPX2	Gene names	NTHL1, NTH1, OCTS3
Domain Architecture
Description	Endonuclease III-like protein 1 (EC 4.2.99.18).

NTHL1_MOUSE
NC score	0.283777 (rank : 4)	θ value	0.000602161 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	O35980	Gene names	Nthl1, Nth1
Domain Architecture
Description	Endonuclease III-like protein 1 (EC 4.2.99.18).

MBTP1_MOUSE
NC score	0.073965 (rank : 5)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

MBTP1_HUMAN
NC score	0.073952 (rank : 6)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).

APOA4_HUMAN
NC score	0.027765 (rank : 7)	θ value	2.36792 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	399	Shared Neighborhood Hits	3
SwissProt Accessions	P06727, Q6Q787	Gene names	APOA4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

RIN1_MOUSE
NC score	0.026463 (rank : 8)	θ value	2.36792 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q921Q7	Gene names	Rin1
Domain Architecture
Description	Ras and Rab interactor 1 (Ras interaction/interference protein 1).

GP162_HUMAN
NC score	0.026076 (rank : 9)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	244	Shared Neighborhood Hits	3
SwissProt Accessions	Q16538, Q16664, Q59EH5, Q66K56	Gene names	GPR162, GRCA
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 162 (Gene-rich cluster gene A protein).

GP162_MOUSE
NC score	0.026045 (rank : 10)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	242	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UN16, O88835	Gene names	Gpr162
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 162.

NCOA2_MOUSE
NC score	0.022215 (rank : 11)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	281	Shared Neighborhood Hits	4
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

CCD22_MOUSE
NC score	0.020410 (rank : 12)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	268	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JIG7, Q8BYH4	Gene names	Ccdc22, DXImx40e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

NCOA2_HUMAN
NC score	0.020304 (rank : 13)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	281	Shared Neighborhood Hits	4
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

CC001_HUMAN
NC score	0.018517 (rank : 14)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NPL8, Q6IAJ7, Q6UWU6, Q9NPR3, Q9NPS5, Q9P0Y6	Gene names	C3orf1
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf1 (Protein M5-14).

CP2B9_MOUSE
NC score	0.015938 (rank : 15)	θ value	0.813845 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	P12790	Gene names	Cyp2b9, Cyp2b-9, Rip
Domain Architecture
Description	Cytochrome P450 2B9 (EC 1.14.14.1) (CYPIIB9) (Testosterone 16-alpha hydroxylase) (P450-16-alpha) (Clone PF26).

EPAS1_HUMAN
NC score	0.015617 (rank : 16)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

CP2BA_MOUSE
NC score	0.014665 (rank : 17)	θ value	1.81305 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	P12791	Gene names	Cyp2b10, Cyp2b-10
Domain Architecture
Description	Cytochrome P450 2B10 (EC 1.14.14.1) (CYPIIB10) (Testosterone 16-alpha hydroxylase) (P450-16-alpha) (Clone PF3/46).

SMOO_HUMAN
NC score	0.014119 (rank : 18)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	391	Shared Neighborhood Hits	3
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

DOK2_MOUSE
NC score	0.011244 (rank : 19)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	244	Shared Neighborhood Hits	3
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

HLXB9_HUMAN
NC score	0.004706 (rank : 20)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	336	Shared Neighborhood Hits	2
SwissProt Accessions	P50219, Q9Y648	Gene names	HLXB9
Domain Architecture
Description	Homeobox protein HB9.