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Network neighborhood for query Sequence : PCSK7_HUMAN

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PCSK7_HUMAN
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PCSK7_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

PCSK7_MOUSE
θ value	0 (rank : 2)	NC score	0.999114 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	24	Shared Neighborhood Hits	15
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

PCSK6_HUMAN
θ value	1.05987e-125 (rank : 3)	NC score	0.864868 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	298	Shared Neighborhood Hits	13
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

PCSK5_MOUSE
θ value	8.39787e-123 (rank : 4)	NC score	0.702830 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	613	Shared Neighborhood Hits	13
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

PCSK5_HUMAN
θ value	5.44333e-122 (rank : 5)	NC score	0.852512 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	291	Shared Neighborhood Hits	13
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

NEC1_MOUSE
θ value	7.6132e-116 (rank : 6)	NC score	0.972107 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

NEC1_HUMAN
θ value	5.45601e-114 (rank : 7)	NC score	0.971102 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

PCSK4_HUMAN
θ value	9.30652e-114 (rank : 8)	NC score	0.968167 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

FURIN_HUMAN
θ value	2.22025e-107 (rank : 9)	NC score	0.961905 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	52	Shared Neighborhood Hits	13
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

FURIN_MOUSE
θ value	4.94618e-107 (rank : 10)	NC score	0.961647 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

PCSK4_MOUSE
θ value	1.34698e-104 (rank : 11)	NC score	0.971124 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	P29121, Q62094	Gene names	Pcsk4, Nec-3, Nec3
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (PC4) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (KEX2-like endoprotease 3).

NEC2_HUMAN
θ value	2.2976e-104 (rank : 12)	NC score	0.968390 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	P16519, Q14927, Q9NQG3, Q9NUG1, Q9UJC6	Gene names	PCSK2, NEC2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

NEC2_MOUSE
θ value	7.39111e-103 (rank : 13)	NC score	0.968159 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

PCSK9_MOUSE
θ value	0.0113563 (rank : 14)	NC score	0.084645 (rank : 24)
Query Neighborhood Hits	21	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q80W65, Q3UEH7, Q8BXW9, Q8CFT6	Gene names	Pcsk9, Narc1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

OSBL9_HUMAN
θ value	1.38821 (rank : 15)	NC score	0.017785 (rank : 32)
Query Neighborhood Hits	21	Target Neighborhood Hits	138	Shared Neighborhood Hits	3
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PSD4_HUMAN
θ value	4.03905 (rank : 16)	NC score	0.007783 (rank : 34)
Query Neighborhood Hits	21	Target Neighborhood Hits	178	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

SQSTM_HUMAN
θ value	4.03905 (rank : 17)	NC score	0.018475 (rank : 30)
Query Neighborhood Hits	21	Target Neighborhood Hits	61	Shared Neighborhood Hits	3
SwissProt Accessions	Q13501, Q13446, Q9BUV7, Q9BVS6, Q9UEU1	Gene names	SQSTM1, ORCA
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (EBI3-associated protein of 60 kDa) (p60) (EBIAP).

SQSTM_MOUSE
θ value	4.03905 (rank : 18)	NC score	0.018329 (rank : 31)
Query Neighborhood Hits	21	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q64337, Q99JM8	Gene names	Sqstm1, A170, STAP
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Ubiquitin-binding protein p62) (STONE14).

TMC2_HUMAN
θ value	4.03905 (rank : 19)	NC score	0.008221 (rank : 33)
Query Neighborhood Hits	21	Target Neighborhood Hits	149	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TDI7, Q5JXT0, Q5JXT1, Q6UWW4, Q6ZS41, Q8N9F3, Q9BYN2, Q9BYN3, Q9BYN4, Q9BYN5	Gene names	TMC2
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 2.

DRD4_MOUSE
θ value	5.27518 (rank : 20)	NC score	-0.000217 (rank : 36)
Query Neighborhood Hits	21	Target Neighborhood Hits	852	Shared Neighborhood Hits	2
SwissProt Accessions	P51436, O35838	Gene names	Drd4
Domain Architecture
Description	D(4) dopamine receptor (Dopamine D4 receptor) (D(2C) dopamine receptor).

FZD7_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.001964 (rank : 35)
Query Neighborhood Hits	21	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	O75084, O94816, Q96B74	Gene names	FZD7
Domain Architecture
Description	Frizzled-7 precursor (Fz-7) (hFz7) (FzE3).

CREL1_HUMAN
θ value	θ > 10 (rank : 22)	NC score	0.062818 (rank : 29)
Query Neighborhood Hits	21	Target Neighborhood Hits	441	Shared Neighborhood Hits	6
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CREL1_MOUSE
θ value	θ > 10 (rank : 23)	NC score	0.063691 (rank : 28)
Query Neighborhood Hits	21	Target Neighborhood Hits	524	Shared Neighborhood Hits	6
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

FRAS1_HUMAN
θ value	θ > 10 (rank : 24)	NC score	0.111043 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	759	Shared Neighborhood Hits	6
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

FRAS1_MOUSE
θ value	θ > 10 (rank : 25)	NC score	0.112369 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	747	Shared Neighborhood Hits	6
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

MBTP1_HUMAN
θ value	θ > 10 (rank : 26)	NC score	0.070079 (rank : 26)
Query Neighborhood Hits	21	Target Neighborhood Hits	28	Shared Neighborhood Hits	9
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).

MBTP1_MOUSE
θ value	θ > 10 (rank : 27)	NC score	0.064597 (rank : 27)
Query Neighborhood Hits	21	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

PCSK9_HUMAN
θ value	θ > 10 (rank : 28)	NC score	0.070314 (rank : 25)
Query Neighborhood Hits	21	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NBP7, Q5PSM5	Gene names	PCSK9, NARC1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

RSPO1_HUMAN
θ value	θ > 10 (rank : 29)	NC score	0.103308 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	101	Shared Neighborhood Hits	5
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

RSPO1_MOUSE
θ value	θ > 10 (rank : 30)	NC score	0.092474 (rank : 23)
Query Neighborhood Hits	21	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

RSPO2_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.100383 (rank : 22)
Query Neighborhood Hits	21	Target Neighborhood Hits	90	Shared Neighborhood Hits	5
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

RSPO2_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.103035 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

RSPO3_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.108120 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	128	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO3_MOUSE
θ value	θ > 10 (rank : 34)	NC score	0.106955 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	120	Shared Neighborhood Hits	5
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO4_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.103024 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

RSPO4_MOUSE
θ value	θ > 10 (rank : 36)	NC score	0.107697 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

Hits sorted by NC score

PCSK7_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

PCSK7_MOUSE
NC score	0.999114 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	24	Shared Neighborhood Hits	15
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

NEC1_MOUSE
NC score	0.972107 (rank : 3)	θ value	7.6132e-116 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

PCSK4_MOUSE
NC score	0.971124 (rank : 4)	θ value	1.34698e-104 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	P29121, Q62094	Gene names	Pcsk4, Nec-3, Nec3
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (PC4) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (KEX2-like endoprotease 3).

NEC1_HUMAN
NC score	0.971102 (rank : 5)	θ value	5.45601e-114 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

NEC2_HUMAN
NC score	0.968390 (rank : 6)	θ value	2.2976e-104 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	P16519, Q14927, Q9NQG3, Q9NUG1, Q9UJC6	Gene names	PCSK2, NEC2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

PCSK4_HUMAN
NC score	0.968167 (rank : 7)	θ value	9.30652e-114 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

NEC2_MOUSE
NC score	0.968159 (rank : 8)	θ value	7.39111e-103 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

FURIN_HUMAN
NC score	0.961905 (rank : 9)	θ value	2.22025e-107 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	52	Shared Neighborhood Hits	13
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

FURIN_MOUSE
NC score	0.961647 (rank : 10)	θ value	4.94618e-107 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

PCSK6_HUMAN
NC score	0.864868 (rank : 11)	θ value	1.05987e-125 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	298	Shared Neighborhood Hits	13
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

PCSK5_HUMAN
NC score	0.852512 (rank : 12)	θ value	5.44333e-122 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	291	Shared Neighborhood Hits	13
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

PCSK5_MOUSE
NC score	0.702830 (rank : 13)	θ value	8.39787e-123 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	613	Shared Neighborhood Hits	13
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

FRAS1_MOUSE
NC score	0.112369 (rank : 14)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	21	Target Neighborhood Hits	747	Shared Neighborhood Hits	6
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

FRAS1_HUMAN
NC score	0.111043 (rank : 15)	θ value	θ > 10 (rank : 24)
Query Neighborhood Hits	21	Target Neighborhood Hits	759	Shared Neighborhood Hits	6
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

RSPO3_HUMAN
NC score	0.108120 (rank : 16)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	21	Target Neighborhood Hits	128	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO4_MOUSE
NC score	0.107697 (rank : 17)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	21	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

RSPO3_MOUSE
NC score	0.106955 (rank : 18)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	21	Target Neighborhood Hits	120	Shared Neighborhood Hits	5
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO1_HUMAN
NC score	0.103308 (rank : 19)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	21	Target Neighborhood Hits	101	Shared Neighborhood Hits	5
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

RSPO2_MOUSE
NC score	0.103035 (rank : 20)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	21	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

RSPO4_HUMAN
NC score	0.103024 (rank : 21)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	21	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

RSPO2_HUMAN
NC score	0.100383 (rank : 22)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	21	Target Neighborhood Hits	90	Shared Neighborhood Hits	5
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

RSPO1_MOUSE
NC score	0.092474 (rank : 23)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	21	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

PCSK9_MOUSE
NC score	0.084645 (rank : 24)	θ value	0.0113563 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q80W65, Q3UEH7, Q8BXW9, Q8CFT6	Gene names	Pcsk9, Narc1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

PCSK9_HUMAN
NC score	0.070314 (rank : 25)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	21	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NBP7, Q5PSM5	Gene names	PCSK9, NARC1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

MBTP1_HUMAN
NC score	0.070079 (rank : 26)	θ value	θ > 10 (rank : 26)
Query Neighborhood Hits	21	Target Neighborhood Hits	28	Shared Neighborhood Hits	9
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).

MBTP1_MOUSE
NC score	0.064597 (rank : 27)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	21	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

CREL1_MOUSE
NC score	0.063691 (rank : 28)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	21	Target Neighborhood Hits	524	Shared Neighborhood Hits	6
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CREL1_HUMAN
NC score	0.062818 (rank : 29)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	21	Target Neighborhood Hits	441	Shared Neighborhood Hits	6
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

SQSTM_HUMAN
NC score	0.018475 (rank : 30)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	61	Shared Neighborhood Hits	3
SwissProt Accessions	Q13501, Q13446, Q9BUV7, Q9BVS6, Q9UEU1	Gene names	SQSTM1, ORCA
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (EBI3-associated protein of 60 kDa) (p60) (EBIAP).

SQSTM_MOUSE
NC score	0.018329 (rank : 31)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q64337, Q99JM8	Gene names	Sqstm1, A170, STAP
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Ubiquitin-binding protein p62) (STONE14).

OSBL9_HUMAN
NC score	0.017785 (rank : 32)	θ value	1.38821 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	138	Shared Neighborhood Hits	3
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

TMC2_HUMAN
NC score	0.008221 (rank : 33)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	149	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TDI7, Q5JXT0, Q5JXT1, Q6UWW4, Q6ZS41, Q8N9F3, Q9BYN2, Q9BYN3, Q9BYN4, Q9BYN5	Gene names	TMC2
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 2.

PSD4_HUMAN
NC score	0.007783 (rank : 34)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	178	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

FZD7_HUMAN
NC score	0.001964 (rank : 35)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	O75084, O94816, Q96B74	Gene names	FZD7
Domain Architecture
Description	Frizzled-7 precursor (Fz-7) (hFz7) (FzE3).

DRD4_MOUSE
NC score	-0.000217 (rank : 36)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	852	Shared Neighborhood Hits	2
SwissProt Accessions	P51436, O35838	Gene names	Drd4
Domain Architecture
Description	D(4) dopamine receptor (Dopamine D4 receptor) (D(2C) dopamine receptor).