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Network neighborhood for query Sequence : PCSK9_MOUSE

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PCSK9_MOUSE
SwissProt Accessions	Q80W65, Q3UEH7, Q8BXW9, Q8CFT6	Gene names	Pcsk9, Narc1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PCSK9_HUMAN
θ value	0 (rank : 1)	NC score	0.989555 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	20	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NBP7, Q5PSM5	Gene names	PCSK9, NARC1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

PCSK9_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q80W65, Q3UEH7, Q8BXW9, Q8CFT6	Gene names	Pcsk9, Narc1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

PCSK7_HUMAN
θ value	0.0113563 (rank : 3)	NC score	0.084645 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

PCSK7_MOUSE
θ value	0.0330416 (rank : 4)	NC score	0.081645 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

2A5D_HUMAN
θ value	0.47712 (rank : 5)	NC score	0.048421 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	59	Shared Neighborhood Hits	5
SwissProt Accessions	Q14738, O00494, O00696, Q15171	Gene names	PPP2R5D
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A, B subunit, B' delta isoform) (PP2A, B subunit, B56 delta isoform) (PP2A, B subunit, PR61 delta isoform) (PP2A, B subunit, R5 delta isoform).

NEC1_HUMAN
θ value	0.813845 (rank : 6)	NC score	0.071284 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

NEC1_MOUSE
θ value	0.813845 (rank : 7)	NC score	0.071441 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

DGKZ_HUMAN
θ value	1.81305 (rank : 8)	NC score	0.025586 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	551	Shared Neighborhood Hits	3
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

DGKZ_MOUSE
θ value	1.81305 (rank : 9)	NC score	0.025511 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	542	Shared Neighborhood Hits	3
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

TPP2_HUMAN
θ value	2.36792 (rank : 10)	NC score	0.049684 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	P29144	Gene names	TPP2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

ATS16_HUMAN
θ value	4.03905 (rank : 11)	NC score	0.011141 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	208	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS16_MOUSE
θ value	4.03905 (rank : 12)	NC score	0.011228 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	179	Shared Neighborhood Hits	3
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

2A5G_MOUSE
θ value	5.27518 (rank : 13)	NC score	0.031076 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	Q60996, O35708, Q99KW8, Q99N67, Q99N68	Gene names	Ppp2r5c
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (PP2A, B subunit, B'alpha3 isoform).

CSMD1_MOUSE
θ value	5.27518 (rank : 14)	NC score	0.007661 (rank : 17)
Query Neighborhood Hits	16	Target Neighborhood Hits	193	Shared Neighborhood Hits	2
SwissProt Accessions	Q923L3, Q8BUV1, Q8BYQ3	Gene names	Csmd1
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

TPP2_MOUSE
θ value	5.27518 (rank : 15)	NC score	0.041579 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q64514	Gene names	Tpp2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

2A5G_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.030015 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q13362, Q14391, Q15060, Q15174	Gene names	PPP2R5C, KIAA0044
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (NY-REN-29 antigen).

NEC2_MOUSE
θ value	θ > 10 (rank : 17)	NC score	0.052975 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

Hits sorted by NC score

PCSK9_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q80W65, Q3UEH7, Q8BXW9, Q8CFT6	Gene names	Pcsk9, Narc1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

PCSK9_HUMAN
NC score	0.989555 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	20	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NBP7, Q5PSM5	Gene names	PCSK9, NARC1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

PCSK7_HUMAN
NC score	0.084645 (rank : 3)	θ value	0.0113563 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

PCSK7_MOUSE
NC score	0.081645 (rank : 4)	θ value	0.0330416 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

NEC1_MOUSE
NC score	0.071441 (rank : 5)	θ value	0.813845 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

NEC1_HUMAN
NC score	0.071284 (rank : 6)	θ value	0.813845 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

NEC2_MOUSE
NC score	0.052975 (rank : 7)	θ value	θ > 10 (rank : 17)
Query Neighborhood Hits	16	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

TPP2_HUMAN
NC score	0.049684 (rank : 8)	θ value	2.36792 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	P29144	Gene names	TPP2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

2A5D_HUMAN
NC score	0.048421 (rank : 9)	θ value	0.47712 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	59	Shared Neighborhood Hits	5
SwissProt Accessions	Q14738, O00494, O00696, Q15171	Gene names	PPP2R5D
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A, B subunit, B' delta isoform) (PP2A, B subunit, B56 delta isoform) (PP2A, B subunit, PR61 delta isoform) (PP2A, B subunit, R5 delta isoform).

TPP2_MOUSE
NC score	0.041579 (rank : 10)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q64514	Gene names	Tpp2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

2A5G_MOUSE
NC score	0.031076 (rank : 11)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	Q60996, O35708, Q99KW8, Q99N67, Q99N68	Gene names	Ppp2r5c
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (PP2A, B subunit, B'alpha3 isoform).

2A5G_HUMAN
NC score	0.030015 (rank : 12)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q13362, Q14391, Q15060, Q15174	Gene names	PPP2R5C, KIAA0044
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (NY-REN-29 antigen).

DGKZ_HUMAN
NC score	0.025586 (rank : 13)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	551	Shared Neighborhood Hits	3
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

DGKZ_MOUSE
NC score	0.025511 (rank : 14)	θ value	1.81305 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	542	Shared Neighborhood Hits	3
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

ATS16_MOUSE
NC score	0.011228 (rank : 15)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	179	Shared Neighborhood Hits	3
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS16_HUMAN
NC score	0.011141 (rank : 16)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	208	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

CSMD1_MOUSE
NC score	0.007661 (rank : 17)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	193	Shared Neighborhood Hits	2
SwissProt Accessions	Q923L3, Q8BUV1, Q8BYQ3	Gene names	Csmd1
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).