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Network neighborhood for query Sequence : 2A5G_HUMAN

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2A5G_HUMAN
SwissProt Accessions	Q13362, Q14391, Q15060, Q15174	Gene names	PPP2R5C, KIAA0044
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (NY-REN-29 antigen).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

2A5D_HUMAN
θ value	0 (rank : 1)	NC score	0.994725 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	59	Shared Neighborhood Hits	11
SwissProt Accessions	Q14738, O00494, O00696, Q15171	Gene names	PPP2R5D
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A, B subunit, B' delta isoform) (PP2A, B subunit, B56 delta isoform) (PP2A, B subunit, PR61 delta isoform) (PP2A, B subunit, R5 delta isoform).

2A5G_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q13362, Q14391, Q15060, Q15174	Gene names	PPP2R5C, KIAA0044
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (NY-REN-29 antigen).

2A5G_MOUSE
θ value	0 (rank : 3)	NC score	0.999523 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	25	Shared Neighborhood Hits	17
SwissProt Accessions	Q60996, O35708, Q99KW8, Q99N67, Q99N68	Gene names	Ppp2r5c
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (PP2A, B subunit, B'alpha3 isoform).

2A5E_HUMAN
θ value	7.75157e-169 (rank : 4)	NC score	0.993281 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q16537	Gene names	PPP2R5E
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A, B subunit, B' epsilon isoform) (PP2A, B subunit, B56 epsilon isoform) (PP2A, B subunit, PR61 epsilon isoform) (PP2A, B subunit, R5 epsilon isoform).

2A5E_MOUSE
θ value	7.75157e-169 (rank : 5)	NC score	0.993296 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q61151, Q3V1I5, Q571M6, Q8C2M2	Gene names	Ppp2r5e, Kiaa4006
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A, B subunit, B' epsilon isoform) (PP2A, B subunit, B56 epsilon isoform) (PP2A, B subunit, PR61 epsilon isoform) (PP2A, B subunit, R5 epsilon isoform).

2A5A_MOUSE
θ value	5.94893e-161 (rank : 6)	NC score	0.992827 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	Q6PD03, Q8R1U7	Gene names	Ppp2r5a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A, B subunit, B' alpha isoform) (PP2A, B subunit, B56 alpha isoform) (PP2A, B subunit, PR61 alpha isoform) (PP2A, B subunit, R5 alpha isoform) (PR61alpha).

2A5A_HUMAN
θ value	1.32529e-160 (rank : 7)	NC score	0.992634 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q15172, Q5VVB2, Q8TBI9	Gene names	PPP2R5A
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A, B subunit, B' alpha isoform) (PP2A, B subunit, B56 alpha isoform) (PP2A, B subunit, PR61 alpha isoform) (PP2A, B subunit, R5 alpha isoform).

2A5B_HUMAN
θ value	1.20145e-153 (rank : 8)	NC score	0.993029 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q15173, Q13853	Gene names	PPP2R5B
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A, B subunit, B' beta isoform) (PP2A, B subunit, B56 beta isoform) (PP2A, B subunit, PR61 beta isoform) (PP2A, B subunit, R5 beta isoform).

LIN1_HUMAN
θ value	0.0736092 (rank : 9)	NC score	0.048165 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	187	Shared Neighborhood Hits	5
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

PEX3_HUMAN
θ value	0.47712 (rank : 10)	NC score	0.062366 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	P56589	Gene names	PEX3
Domain Architecture
Description	Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3).

HSF1_MOUSE
θ value	1.38821 (rank : 11)	NC score	0.021074 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	267	Shared Neighborhood Hits	3
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

PML_HUMAN
θ value	1.38821 (rank : 12)	NC score	0.021411 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	248	Shared Neighborhood Hits	3
SwissProt Accessions	P29590, P29591, P29592, P29593, Q00755	Gene names	PML, MYL, RNF71, TRIM19
Domain Architecture
Description	Probable transcription factor PML (Tripartite motif-containing protein 19) (RING finger protein 71).

ANFB_MOUSE
θ value	4.03905 (rank : 13)	NC score	0.027314 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P40753	Gene names	Nppb
Domain Architecture
Description	Natriuretic peptides B precursor [Contains: Gamma-brain natriuretic peptide; Brain natriuretic peptide (BNP)].

SYCP1_MOUSE
θ value	5.27518 (rank : 14)	NC score	0.001289 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	1456	Shared Neighborhood Hits	6
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

UTRO_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.004183 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	960	Shared Neighborhood Hits	6
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

ARHGG_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.013175 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	129	Shared Neighborhood Hits	4
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

PCSK9_MOUSE
θ value	6.88961 (rank : 17)	NC score	0.030015 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q80W65, Q3UEH7, Q8BXW9, Q8CFT6	Gene names	Pcsk9, Narc1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

CEP35_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.004903 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	811	Shared Neighborhood Hits	7
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

FRMD6_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.010453 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

FRMD6_MOUSE
θ value	8.99809 (rank : 20)	NC score	0.010399 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

PERQ1_MOUSE
θ value	8.99809 (rank : 21)	NC score	0.008474 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	215	Shared Neighborhood Hits	3
SwissProt Accessions	Q99MR1	Gene names	Perq1
Domain Architecture
Description	PERQ amino acid rich with GYF domain protein 1.

TUFT1_HUMAN
θ value	8.99809 (rank : 22)	NC score	0.002184 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	686	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

Hits sorted by NC score

2A5G_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q13362, Q14391, Q15060, Q15174	Gene names	PPP2R5C, KIAA0044
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (NY-REN-29 antigen).

2A5G_MOUSE
NC score	0.999523 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	25	Shared Neighborhood Hits	17
SwissProt Accessions	Q60996, O35708, Q99KW8, Q99N67, Q99N68	Gene names	Ppp2r5c
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (PP2A, B subunit, B'alpha3 isoform).

2A5D_HUMAN
NC score	0.994725 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	59	Shared Neighborhood Hits	11
SwissProt Accessions	Q14738, O00494, O00696, Q15171	Gene names	PPP2R5D
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A, B subunit, B' delta isoform) (PP2A, B subunit, B56 delta isoform) (PP2A, B subunit, PR61 delta isoform) (PP2A, B subunit, R5 delta isoform).

2A5E_MOUSE
NC score	0.993296 (rank : 4)	θ value	7.75157e-169 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q61151, Q3V1I5, Q571M6, Q8C2M2	Gene names	Ppp2r5e, Kiaa4006
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A, B subunit, B' epsilon isoform) (PP2A, B subunit, B56 epsilon isoform) (PP2A, B subunit, PR61 epsilon isoform) (PP2A, B subunit, R5 epsilon isoform).

2A5E_HUMAN
NC score	0.993281 (rank : 5)	θ value	7.75157e-169 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q16537	Gene names	PPP2R5E
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A, B subunit, B' epsilon isoform) (PP2A, B subunit, B56 epsilon isoform) (PP2A, B subunit, PR61 epsilon isoform) (PP2A, B subunit, R5 epsilon isoform).

2A5B_HUMAN
NC score	0.993029 (rank : 6)	θ value	1.20145e-153 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q15173, Q13853	Gene names	PPP2R5B
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A, B subunit, B' beta isoform) (PP2A, B subunit, B56 beta isoform) (PP2A, B subunit, PR61 beta isoform) (PP2A, B subunit, R5 beta isoform).

2A5A_MOUSE
NC score	0.992827 (rank : 7)	θ value	5.94893e-161 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	Q6PD03, Q8R1U7	Gene names	Ppp2r5a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A, B subunit, B' alpha isoform) (PP2A, B subunit, B56 alpha isoform) (PP2A, B subunit, PR61 alpha isoform) (PP2A, B subunit, R5 alpha isoform) (PR61alpha).

2A5A_HUMAN
NC score	0.992634 (rank : 8)	θ value	1.32529e-160 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q15172, Q5VVB2, Q8TBI9	Gene names	PPP2R5A
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A, B subunit, B' alpha isoform) (PP2A, B subunit, B56 alpha isoform) (PP2A, B subunit, PR61 alpha isoform) (PP2A, B subunit, R5 alpha isoform).

PEX3_HUMAN
NC score	0.062366 (rank : 9)	θ value	0.47712 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	P56589	Gene names	PEX3
Domain Architecture
Description	Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3).

LIN1_HUMAN
NC score	0.048165 (rank : 10)	θ value	0.0736092 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	187	Shared Neighborhood Hits	5
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

PCSK9_MOUSE
NC score	0.030015 (rank : 11)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q80W65, Q3UEH7, Q8BXW9, Q8CFT6	Gene names	Pcsk9, Narc1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

ANFB_MOUSE
NC score	0.027314 (rank : 12)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P40753	Gene names	Nppb
Domain Architecture
Description	Natriuretic peptides B precursor [Contains: Gamma-brain natriuretic peptide; Brain natriuretic peptide (BNP)].

PML_HUMAN
NC score	0.021411 (rank : 13)	θ value	1.38821 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	248	Shared Neighborhood Hits	3
SwissProt Accessions	P29590, P29591, P29592, P29593, Q00755	Gene names	PML, MYL, RNF71, TRIM19
Domain Architecture
Description	Probable transcription factor PML (Tripartite motif-containing protein 19) (RING finger protein 71).

HSF1_MOUSE
NC score	0.021074 (rank : 14)	θ value	1.38821 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	267	Shared Neighborhood Hits	3
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

ARHGG_HUMAN
NC score	0.013175 (rank : 15)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	129	Shared Neighborhood Hits	4
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

FRMD6_HUMAN
NC score	0.010453 (rank : 16)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

FRMD6_MOUSE
NC score	0.010399 (rank : 17)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

PERQ1_MOUSE
NC score	0.008474 (rank : 18)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	215	Shared Neighborhood Hits	3
SwissProt Accessions	Q99MR1	Gene names	Perq1
Domain Architecture
Description	PERQ amino acid rich with GYF domain protein 1.

CEP35_HUMAN
NC score	0.004903 (rank : 19)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	811	Shared Neighborhood Hits	7
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

UTRO_HUMAN
NC score	0.004183 (rank : 20)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	960	Shared Neighborhood Hits	6
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

TUFT1_HUMAN
NC score	0.002184 (rank : 21)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	686	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

SYCP1_MOUSE
NC score	0.001289 (rank : 22)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	1456	Shared Neighborhood Hits	6
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).