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Network neighborhood for query Sequence : MK_HUMAN

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MK_HUMAN
SwissProt Accessions	P21741	Gene names	MDK, MK1, NEGF2
Domain Architecture
Description	Midkine precursor (MK) (Neurite outgrowth-promoting protein) (Midgestation and kidney protein) (Amphiregulin-associated protein) (ARAP) (Neurite outgrowth-promoting factor 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MK_HUMAN
θ value	1.78386e-56 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	P21741	Gene names	MDK, MK1, NEGF2
Domain Architecture
Description	Midkine precursor (MK) (Neurite outgrowth-promoting protein) (Midgestation and kidney protein) (Amphiregulin-associated protein) (ARAP) (Neurite outgrowth-promoting factor 2).

MK_MOUSE
θ value	1.04822e-48 (rank : 2)	NC score	0.994991 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	P12025	Gene names	Mdk, Mk
Domain Architecture
Description	Midkine precursor (MK) (Retinoic acid-induced differentiation factor).

PTN_HUMAN
θ value	1.85889e-29 (rank : 3)	NC score	0.949894 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	7	Shared Neighborhood Hits	5
SwissProt Accessions	P21246	Gene names	PTN, HBNF1, NEGF1
Domain Architecture
Description	Pleiotrophin precursor (PTN) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding growth factor 8) (HBGF-8) (Osteoblast-specific factor 1) (OSF-1) (Heparin-binding neurite outgrowth-promoting factor 1) (HBNF-1) (Heparin-binding brain mitogen) (HBBM).

PTN_MOUSE
θ value	3.17079e-29 (rank : 4)	NC score	0.947125 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	7	Shared Neighborhood Hits	5
SwissProt Accessions	P63089, P20935	Gene names	Ptn
Domain Architecture	No domain graphic available
Description	Pleiotrophin precursor (PTN) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding growth factor 8) (HBGF-8) (Osteoblast-specific factor 1) (OSF-1) (Heparin-binding neutrophic factor) (HBNF) (Heparin-binding brain mitogen) (HBBM).

CO6_HUMAN
θ value	0.47712 (rank : 5)	NC score	0.046953 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	331	Shared Neighborhood Hits	9
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

ATS12_MOUSE
θ value	0.813845 (rank : 6)	NC score	0.042584 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	220	Shared Neighborhood Hits	10
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

SSPO_MOUSE
θ value	1.38821 (rank : 7)	NC score	0.028821 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	800	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

ATS9_HUMAN
θ value	2.36792 (rank : 8)	NC score	0.036620 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	219	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

ATS15_HUMAN
θ value	3.0926 (rank : 9)	NC score	0.030033 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	151	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TE58	Gene names	ADAMTS15
Domain Architecture
Description	ADAMTS-15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 15) (ADAM-TS 15) (ADAM-TS15).

ATS17_HUMAN
θ value	5.27518 (rank : 10)	NC score	0.035137 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	194	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

RSPO1_MOUSE
θ value	8.99809 (rank : 11)	NC score	0.023586 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

Hits sorted by NC score

MK_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.78386e-56 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	P21741	Gene names	MDK, MK1, NEGF2
Domain Architecture
Description	Midkine precursor (MK) (Neurite outgrowth-promoting protein) (Midgestation and kidney protein) (Amphiregulin-associated protein) (ARAP) (Neurite outgrowth-promoting factor 2).

MK_MOUSE
NC score	0.994991 (rank : 2)	θ value	1.04822e-48 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	P12025	Gene names	Mdk, Mk
Domain Architecture
Description	Midkine precursor (MK) (Retinoic acid-induced differentiation factor).

PTN_HUMAN
NC score	0.949894 (rank : 3)	θ value	1.85889e-29 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	7	Shared Neighborhood Hits	5
SwissProt Accessions	P21246	Gene names	PTN, HBNF1, NEGF1
Domain Architecture
Description	Pleiotrophin precursor (PTN) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding growth factor 8) (HBGF-8) (Osteoblast-specific factor 1) (OSF-1) (Heparin-binding neurite outgrowth-promoting factor 1) (HBNF-1) (Heparin-binding brain mitogen) (HBBM).

PTN_MOUSE
NC score	0.947125 (rank : 4)	θ value	3.17079e-29 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	7	Shared Neighborhood Hits	5
SwissProt Accessions	P63089, P20935	Gene names	Ptn
Domain Architecture	No domain graphic available
Description	Pleiotrophin precursor (PTN) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding growth factor 8) (HBGF-8) (Osteoblast-specific factor 1) (OSF-1) (Heparin-binding neutrophic factor) (HBNF) (Heparin-binding brain mitogen) (HBBM).

CO6_HUMAN
NC score	0.046953 (rank : 5)	θ value	0.47712 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	331	Shared Neighborhood Hits	9
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

ATS12_MOUSE
NC score	0.042584 (rank : 6)	θ value	0.813845 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	220	Shared Neighborhood Hits	10
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS9_HUMAN
NC score	0.036620 (rank : 7)	θ value	2.36792 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	219	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

ATS17_HUMAN
NC score	0.035137 (rank : 8)	θ value	5.27518 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	194	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

ATS15_HUMAN
NC score	0.030033 (rank : 9)	θ value	3.0926 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	151	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TE58	Gene names	ADAMTS15
Domain Architecture
Description	ADAMTS-15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 15) (ADAM-TS 15) (ADAM-TS15).

SSPO_MOUSE
NC score	0.028821 (rank : 10)	θ value	1.38821 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	800	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

RSPO1_MOUSE
NC score	0.023586 (rank : 11)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).