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Network neighborhood for query Sequence : MK_MOUSE

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MK_MOUSE
SwissProt Accessions	P12025	Gene names	Mdk, Mk
Domain Architecture
Description	Midkine precursor (MK) (Retinoic acid-induced differentiation factor).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MK_MOUSE
θ value	1.2784e-54 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	P12025	Gene names	Mdk, Mk
Domain Architecture
Description	Midkine precursor (MK) (Retinoic acid-induced differentiation factor).

MK_HUMAN
θ value	1.04822e-48 (rank : 2)	NC score	0.994991 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	P21741	Gene names	MDK, MK1, NEGF2
Domain Architecture
Description	Midkine precursor (MK) (Neurite outgrowth-promoting protein) (Midgestation and kidney protein) (Amphiregulin-associated protein) (ARAP) (Neurite outgrowth-promoting factor 2).

PTN_HUMAN
θ value	4.89182e-30 (rank : 3)	NC score	0.949850 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	7	Shared Neighborhood Hits	5
SwissProt Accessions	P21246	Gene names	PTN, HBNF1, NEGF1
Domain Architecture
Description	Pleiotrophin precursor (PTN) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding growth factor 8) (HBGF-8) (Osteoblast-specific factor 1) (OSF-1) (Heparin-binding neurite outgrowth-promoting factor 1) (HBNF-1) (Heparin-binding brain mitogen) (HBBM).

PTN_MOUSE
θ value	8.3442e-30 (rank : 4)	NC score	0.947164 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	7	Shared Neighborhood Hits	5
SwissProt Accessions	P63089, P20935	Gene names	Ptn
Domain Architecture	No domain graphic available
Description	Pleiotrophin precursor (PTN) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding growth factor 8) (HBGF-8) (Osteoblast-specific factor 1) (OSF-1) (Heparin-binding neutrophic factor) (HBNF) (Heparin-binding brain mitogen) (HBBM).

ATS12_MOUSE
θ value	0.47712 (rank : 5)	NC score	0.055234 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	220	Shared Neighborhood Hits	16
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS17_HUMAN
θ value	0.47712 (rank : 6)	NC score	0.050605 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	194	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

ATS9_HUMAN
θ value	0.47712 (rank : 7)	NC score	0.050413 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	219	Shared Neighborhood Hits	15
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

CO6_HUMAN
θ value	3.0926 (rank : 8)	NC score	0.052470 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	331	Shared Neighborhood Hits	19
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

SEM5B_MOUSE
θ value	3.0926 (rank : 9)	NC score	0.032817 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	190	Shared Neighborhood Hits	13
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

RSPO1_MOUSE
θ value	4.03905 (rank : 10)	NC score	0.038270 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

RSPO3_HUMAN
θ value	4.03905 (rank : 11)	NC score	0.029784 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	128	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

SEM5B_HUMAN
θ value	5.27518 (rank : 12)	NC score	0.031960 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	178	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

SORL_HUMAN
θ value	5.27518 (rank : 13)	NC score	0.017743 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	440	Shared Neighborhood Hits	8
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

SSPO_MOUSE
θ value	5.27518 (rank : 14)	NC score	0.040642 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	800	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

ATS2_MOUSE
θ value	6.88961 (rank : 15)	NC score	0.041571 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	179	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

NOTC4_MOUSE
θ value	6.88961 (rank : 16)	NC score	0.005398 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	872	Shared Neighborhood Hits	10
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

ATS14_HUMAN
θ value	8.99809 (rank : 17)	NC score	0.040436 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	382	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

CO8B_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.039821 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	224	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

PROP_MOUSE
θ value	8.99809 (rank : 19)	NC score	0.041745 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	165	Shared Neighborhood Hits	16
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

SORL_MOUSE
θ value	8.99809 (rank : 20)	NC score	0.017025 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	439	Shared Neighborhood Hits	7
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

SPON1_MOUSE
θ value	8.99809 (rank : 21)	NC score	0.044851 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	123	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

Hits sorted by NC score

MK_MOUSE
NC score	0.999962 (rank : 1)	θ value	1.2784e-54 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	P12025	Gene names	Mdk, Mk
Domain Architecture
Description	Midkine precursor (MK) (Retinoic acid-induced differentiation factor).

MK_HUMAN
NC score	0.994991 (rank : 2)	θ value	1.04822e-48 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	P21741	Gene names	MDK, MK1, NEGF2
Domain Architecture
Description	Midkine precursor (MK) (Neurite outgrowth-promoting protein) (Midgestation and kidney protein) (Amphiregulin-associated protein) (ARAP) (Neurite outgrowth-promoting factor 2).

PTN_HUMAN
NC score	0.949850 (rank : 3)	θ value	4.89182e-30 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	7	Shared Neighborhood Hits	5
SwissProt Accessions	P21246	Gene names	PTN, HBNF1, NEGF1
Domain Architecture
Description	Pleiotrophin precursor (PTN) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding growth factor 8) (HBGF-8) (Osteoblast-specific factor 1) (OSF-1) (Heparin-binding neurite outgrowth-promoting factor 1) (HBNF-1) (Heparin-binding brain mitogen) (HBBM).

PTN_MOUSE
NC score	0.947164 (rank : 4)	θ value	8.3442e-30 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	7	Shared Neighborhood Hits	5
SwissProt Accessions	P63089, P20935	Gene names	Ptn
Domain Architecture	No domain graphic available
Description	Pleiotrophin precursor (PTN) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding growth factor 8) (HBGF-8) (Osteoblast-specific factor 1) (OSF-1) (Heparin-binding neutrophic factor) (HBNF) (Heparin-binding brain mitogen) (HBBM).

ATS12_MOUSE
NC score	0.055234 (rank : 5)	θ value	0.47712 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	220	Shared Neighborhood Hits	16
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

CO6_HUMAN
NC score	0.052470 (rank : 6)	θ value	3.0926 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	331	Shared Neighborhood Hits	19
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

ATS17_HUMAN
NC score	0.050605 (rank : 7)	θ value	0.47712 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	194	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

ATS9_HUMAN
NC score	0.050413 (rank : 8)	θ value	0.47712 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	219	Shared Neighborhood Hits	15
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

SPON1_MOUSE
NC score	0.044851 (rank : 9)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	123	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

PROP_MOUSE
NC score	0.041745 (rank : 10)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	165	Shared Neighborhood Hits	16
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

ATS2_MOUSE
NC score	0.041571 (rank : 11)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	179	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

SSPO_MOUSE
NC score	0.040642 (rank : 12)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	800	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

ATS14_HUMAN
NC score	0.040436 (rank : 13)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	382	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

CO8B_MOUSE
NC score	0.039821 (rank : 14)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	224	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

RSPO1_MOUSE
NC score	0.038270 (rank : 15)	θ value	4.03905 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

SEM5B_MOUSE
NC score	0.032817 (rank : 16)	θ value	3.0926 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	190	Shared Neighborhood Hits	13
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

SEM5B_HUMAN
NC score	0.031960 (rank : 17)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	178	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

RSPO3_HUMAN
NC score	0.029784 (rank : 18)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	128	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

SORL_HUMAN
NC score	0.017743 (rank : 19)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	440	Shared Neighborhood Hits	8
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

SORL_MOUSE
NC score	0.017025 (rank : 20)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	439	Shared Neighborhood Hits	7
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

NOTC4_MOUSE
NC score	0.005398 (rank : 21)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	872	Shared Neighborhood Hits	10
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].